vanoxerine has been researched along with Encephalopathy, Toxic in 3 studies
vanoxerine: structure given in first source
vanoxerine : An N-alkylpiperazine that consists of piperazine bearing 2-bis(4-fluorophenyl)methoxy]ethyl and 3-phenylpropyl groups at positions 1 and 4 respectively. Potent, competitive inhibitor of dopamine uptake (Ki = 1 nM for inhibition of striatal dopamine uptake). Has > 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigma ligand (IC50 = 48 nM). Centrally active following systemic administration.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Drugs were subsequently tested for potential long-lasting effects on brain tissue 5-HT after repeated dosing (2." | 1.31 | Serotonin transporters, serotonin release, and the mechanism of fenfluramine neurotoxicity. ( Ayestas, MA; Baumann, MH; Dersch, CM; Partilla, JS; Rothman, RB, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (66.67) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Oliva, I | 1 |
| Fernández, M | 1 |
| Martín, ED | 1 |
| Hamann, J | 1 |
| Rommelspacher, H | 1 |
| Storch, A | 1 |
| Reichmann, H | 1 |
| Gille, G | 1 |
| Baumann, MH | 1 |
| Ayestas, MA | 1 |
| Dersch, CM | 1 |
| Partilla, JS | 1 |
| Rothman, RB | 1 |
3 other studies available for vanoxerine and Encephalopathy, Toxic
| Article | Year |
|---|---|
Dopamine release regulation by astrocytes during cerebral ischemia.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Aspartic Acid; Astrocytes; Calcium; Corpus Striatum; | 2013 |
Neurotoxic mechanisms of 2,9-dimethyl-beta-carbolinium ion in primary dopaminergic culture.
Topics: Adenosine Triphosphate; Animals; Carbolines; Caspase 3; Caspases; Cell Death; Cell Nucleus; Cells, C | 2006 |
Serotonin transporters, serotonin release, and the mechanism of fenfluramine neurotoxicity.
Topics: Analysis of Variance; Animals; Brain; Brain Chemistry; Chromatography, High Pressure Liquid; Disease | 2000 |