vanoxerine has been researched along with Deficiency, Ascorbic Acid in 2 studies
vanoxerine: structure given in first source
vanoxerine : An N-alkylpiperazine that consists of piperazine bearing 2-bis(4-fluorophenyl)methoxy]ethyl and 3-phenylpropyl groups at positions 1 and 4 respectively. Potent, competitive inhibitor of dopamine uptake (Ki = 1 nM for inhibition of striatal dopamine uptake). Has > 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigma ligand (IC50 = 48 nM). Centrally active following systemic administration.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Schizophrenia is associated with a cerebral glutathione deficit, which may leave the brain susceptible to oxidants." | 1.32 | Low brain glutathione and ascorbic acid associated with dopamine uptake inhibition during rat's development induce long-term cognitive deficit: relevance to schizophrenia. ( Castagné, V; Cuenod, M; Do, KQ; Rougemont, M, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rougemont, M | 2 |
| Do, KQ | 2 |
| Castagné, V | 2 |
| Cuenod, M | 1 |
2 other studies available for vanoxerine and Deficiency, Ascorbic Acid
| Article | Year |
|---|---|
New model of glutathione deficit during development: Effect on lipid peroxidation in the rat brain.
Topics: Animals; Ascorbic Acid Deficiency; Brain; Brain Chemistry; Buthionine Sulfoximine; Chromatography, H | 2002 |
Low brain glutathione and ascorbic acid associated with dopamine uptake inhibition during rat's development induce long-term cognitive deficit: relevance to schizophrenia.
Topics: Animals; Ascorbic Acid Deficiency; Body Weight; Brain; Brain Chemistry; Buthionine Sulfoximine; Cogn | 2004 |