Page last updated: 2024-10-27

vanoxerine and Cognition Disorders

vanoxerine has been researched along with Cognition Disorders in 2 studies

vanoxerine: structure given in first source
vanoxerine : An N-alkylpiperazine that consists of piperazine bearing 2-bis(4-fluorophenyl)methoxy]ethyl and 3-phenylpropyl groups at positions 1 and 4 respectively. Potent, competitive inhibitor of dopamine uptake (Ki = 1 nM for inhibition of striatal dopamine uptake). Has > 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigma ligand (IC50 = 48 nM). Centrally active following systemic administration.

Cognition Disorders: Disorders characterized by disturbances in mental processes related to learning, thinking, reasoning, and judgment.

Research Excerpts

ExcerptRelevanceReference
"Schizophrenia is associated with a cerebral glutathione deficit, which may leave the brain susceptible to oxidants."1.32Low brain glutathione and ascorbic acid associated with dopamine uptake inhibition during rat's development induce long-term cognitive deficit: relevance to schizophrenia. ( Castagné, V; Cuenod, M; Do, KQ; Rougemont, M, 2004)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Castagné, V2
Cuénod, M2
Do, KQ2
Rougemont, M1

Other Studies

2 other studies available for vanoxerine and Cognition Disorders

ArticleYear
An animal model with relevance to schizophrenia: sex-dependent cognitive deficits in osteogenic disorder-Shionogi rats induced by glutathione synthesis and dopamine uptake inhibition during development.
    Neuroscience, 2004, Volume: 123, Issue:4

    Topics: Aging; Animals; Animals, Newborn; Behavior, Animal; Body Weight; Brain Chemistry; Buthionine Sulfoxi

2004
Low brain glutathione and ascorbic acid associated with dopamine uptake inhibition during rat's development induce long-term cognitive deficit: relevance to schizophrenia.
    Neurobiology of disease, 2004, Volume: 15, Issue:1

    Topics: Animals; Ascorbic Acid Deficiency; Body Weight; Brain; Brain Chemistry; Buthionine Sulfoximine; Cogn

2004