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vanoxerine and Chemical Dependence

vanoxerine has been researched along with Chemical Dependence in 8 studies

vanoxerine: structure given in first source
vanoxerine : An N-alkylpiperazine that consists of piperazine bearing 2-bis(4-fluorophenyl)methoxy]ethyl and 3-phenylpropyl groups at positions 1 and 4 respectively. Potent, competitive inhibitor of dopamine uptake (Ki = 1 nM for inhibition of striatal dopamine uptake). Has > 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigma ligand (IC50 = 48 nM). Centrally active following systemic administration.

Research Excerpts

ExcerptRelevanceReference
"Pretreatment with bromocriptine (0."1.30Effects of proposed treatments for cocaine addiction on hemodynamic responsiveness to cocaine in conscious rats. ( Gan, Q; Knuepfer, MM, 1997)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's6 (75.00)18.2507
2000's1 (12.50)29.6817
2010's1 (12.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Matecka, D2
Rothman, RB2
Radesca, L1
de Costa, BR1
Dersch, CM1
Partilla, JS1
Pert, A1
Glowa, JR2
Wojnicki, FH1
Rice, KC2
Pandit, D1
Fiorentino, A1
Bindra, S1
Venanzi, CA1
Barbier, E1
Zapata, A1
Oh, E1
Liu, Q1
Zhu, F1
Undie, A1
Shippenberg, T1
Wang, JB1
Skjoldager, P1
Winger, G1
Woods, JH1
Fantegrossi, WE1
Lewis, DB1
Gorelick, DA1
Knuepfer, MM1
Gan, Q1
Newman, AH1
Agoston, GE1

Reviews

1 review available for vanoxerine and Chemical Dependence

ArticleYear
Novel benztropine [3a-(diphenylmethoxy)tropane] analogs as probes for the dopamine transporter.
    Current medicinal chemistry, 1998, Volume: 5, Issue:4

    Topics: Benztropine; Carrier Proteins; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake

1998

Other Studies

7 other studies available for vanoxerine and Chemical Dependence

ArticleYear
Development of novel, potent, and selective dopamine reuptake inhibitors through alteration of the piperazine ring of 1-[2-(diphenylmethoxy)ethyl]-and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909).
    Journal of medicinal chemistry, 1996, Nov-22, Volume: 39, Issue:24

    Topics: Animals; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine

1996
Singular value decomposition analysis of the torsional angles of dopamine reuptake inhibitor GBR 12909 analogs: effect of force field and charges.
    Journal of molecular modeling, 2011, Volume: 17, Issue:6

    Topics: Dopamine Uptake Inhibitors; Drug Stability; Models, Molecular; Molecular Conformation; Piperazines;

2011
Supersensitivity to amphetamine in protein kinase-C interacting protein/HINT1 knockout mice.
    Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2007, Volume: 32, Issue:8

    Topics: Amphetamine; Analysis of Variance; Animals; Apomorphine; Behavior, Animal; Brain; Brain Chemistry; D

2007
Effects of GBR 12909 and cocaine on cocaine-maintained behavior in rhesus monkeys.
    Drug and alcohol dependence, 1993, Volume: 33, Issue:1

    Topics: Animals; Arousal; Behavior, Animal; Cocaine; Dose-Response Relationship, Drug; Female; Macaca mulatt

1993
Sustained decrease in cocaine-maintained responding in rhesus monkeys with 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-hydroxy-3-phenylpropyl) piperazinyl decanoate, a long-acting ester derivative of GBR 12909.
    Journal of medicinal chemistry, 1996, Nov-22, Volume: 39, Issue:24

    Topics: Animals; Behavior, Animal; Cocaine; Decanoates; Dopamine Uptake Inhibitors; Macaca mulatta; Male; Mo

1996
The rate hypothesis and agonist substitution approaches to cocaine abuse treatment.
    Advances in pharmacology (San Diego, Calif.), 1998, Volume: 42

    Topics: Animals; Bupropion; Cocaine; Dopamine Uptake Inhibitors; Humans; Mazindol; Piperazines; Substance-Re

1998
Effects of proposed treatments for cocaine addiction on hemodynamic responsiveness to cocaine in conscious rats.
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 283, Issue:2

    Topics: Animals; Bromocriptine; Buprenorphine; Cocaine; Desipramine; Diazepam; Dizocilpine Maleate; Hemodyna

1997