vanoxerine has been researched along with Chemical Dependence in 8 studies
vanoxerine: structure given in first source
vanoxerine : An N-alkylpiperazine that consists of piperazine bearing 2-bis(4-fluorophenyl)methoxy]ethyl and 3-phenylpropyl groups at positions 1 and 4 respectively. Potent, competitive inhibitor of dopamine uptake (Ki = 1 nM for inhibition of striatal dopamine uptake). Has > 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigma ligand (IC50 = 48 nM). Centrally active following systemic administration.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pretreatment with bromocriptine (0." | 1.30 | Effects of proposed treatments for cocaine addiction on hemodynamic responsiveness to cocaine in conscious rats. ( Gan, Q; Knuepfer, MM, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (75.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Matecka, D | 2 |
| Rothman, RB | 2 |
| Radesca, L | 1 |
| de Costa, BR | 1 |
| Dersch, CM | 1 |
| Partilla, JS | 1 |
| Pert, A | 1 |
| Glowa, JR | 2 |
| Wojnicki, FH | 1 |
| Rice, KC | 2 |
| Pandit, D | 1 |
| Fiorentino, A | 1 |
| Bindra, S | 1 |
| Venanzi, CA | 1 |
| Barbier, E | 1 |
| Zapata, A | 1 |
| Oh, E | 1 |
| Liu, Q | 1 |
| Zhu, F | 1 |
| Undie, A | 1 |
| Shippenberg, T | 1 |
| Wang, JB | 1 |
| Skjoldager, P | 1 |
| Winger, G | 1 |
| Woods, JH | 1 |
| Fantegrossi, WE | 1 |
| Lewis, DB | 1 |
| Gorelick, DA | 1 |
| Knuepfer, MM | 1 |
| Gan, Q | 1 |
| Newman, AH | 1 |
| Agoston, GE | 1 |
1 review available for vanoxerine and Chemical Dependence
| Article | Year |
|---|---|
Novel benztropine [3a-(diphenylmethoxy)tropane] analogs as probes for the dopamine transporter.
Topics: Benztropine; Carrier Proteins; Cocaine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake | 1998 |
7 other studies available for vanoxerine and Chemical Dependence
| Article | Year |
|---|---|
Development of novel, potent, and selective dopamine reuptake inhibitors through alteration of the piperazine ring of 1-[2-(diphenylmethoxy)ethyl]-and 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909).
Topics: Animals; Carrier Proteins; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine | 1996 |
Singular value decomposition analysis of the torsional angles of dopamine reuptake inhibitor GBR 12909 analogs: effect of force field and charges.
Topics: Dopamine Uptake Inhibitors; Drug Stability; Models, Molecular; Molecular Conformation; Piperazines; | 2011 |
Supersensitivity to amphetamine in protein kinase-C interacting protein/HINT1 knockout mice.
Topics: Amphetamine; Analysis of Variance; Animals; Apomorphine; Behavior, Animal; Brain; Brain Chemistry; D | 2007 |
Effects of GBR 12909 and cocaine on cocaine-maintained behavior in rhesus monkeys.
Topics: Animals; Arousal; Behavior, Animal; Cocaine; Dose-Response Relationship, Drug; Female; Macaca mulatt | 1993 |
Sustained decrease in cocaine-maintained responding in rhesus monkeys with 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-hydroxy-3-phenylpropyl) piperazinyl decanoate, a long-acting ester derivative of GBR 12909.
Topics: Animals; Behavior, Animal; Cocaine; Decanoates; Dopamine Uptake Inhibitors; Macaca mulatta; Male; Mo | 1996 |
The rate hypothesis and agonist substitution approaches to cocaine abuse treatment.
Topics: Animals; Bupropion; Cocaine; Dopamine Uptake Inhibitors; Humans; Mazindol; Piperazines; Substance-Re | 1998 |
Effects of proposed treatments for cocaine addiction on hemodynamic responsiveness to cocaine in conscious rats.
Topics: Animals; Bromocriptine; Buprenorphine; Cocaine; Desipramine; Diazepam; Dizocilpine Maleate; Hemodyna | 1997 |