Page last updated: 2024-10-27

vanoxerine and Brain Ischemia

vanoxerine has been researched along with Brain Ischemia in 1 studies

vanoxerine: structure given in first source
vanoxerine : An N-alkylpiperazine that consists of piperazine bearing 2-bis(4-fluorophenyl)methoxy]ethyl and 3-phenylpropyl groups at positions 1 and 4 respectively. Potent, competitive inhibitor of dopamine uptake (Ki = 1 nM for inhibition of striatal dopamine uptake). Has > 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigma ligand (IC50 = 48 nM). Centrally active following systemic administration.

Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Maginn, M1
Kelly, JP1
Leonard, BE1

Other Studies

1 other study available for vanoxerine and Brain Ischemia

ArticleYear
Protective effects of vanoxeamine (GBR 12909) against ischaemia-induced hyperactivity and neurodegeneration in the gerbil model of cerebral ischaemia.
    Pharmacology, biochemistry, and behavior, 1997, Volume: 56, Issue:4

    Topics: Animals; Brain Ischemia; Cell Death; Dopamine; Dopamine Uptake Inhibitors; Gerbillinae; Hippocampus;

1997