vanoxerine has been researched along with Bipolar Disorder in 8 studies
vanoxerine: structure given in first source
vanoxerine : An N-alkylpiperazine that consists of piperazine bearing 2-bis(4-fluorophenyl)methoxy]ethyl and 3-phenylpropyl groups at positions 1 and 4 respectively. Potent, competitive inhibitor of dopamine uptake (Ki = 1 nM for inhibition of striatal dopamine uptake). Has > 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigma ligand (IC50 = 48 nM). Centrally active following systemic administration.
Bipolar Disorder: A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Using the GBR 12909 mania model, we observed the classical hyperactivity phenotype, along with low depressive-like but high anxiety-like behaviors." | 1.72 | Assessing positive and negative valence systems to refine animal models of bipolar disorders: the example of GBR 12909-induced manic phenotype. ( Alonso, M; Bigot, M; Henry, C; Lledo, PM; Vicq, E, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 7 (87.50) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Bigot, M | 1 |
| Vicq, E | 1 |
| Lledo, PM | 1 |
| Alonso, M | 1 |
| Henry, C | 1 |
| Bastos, JR | 1 |
| Perico, KM | 1 |
| Marciano Vieira, ÉL | 1 |
| Teixeira, AL | 1 |
| Machado, FS | 1 |
| de Miranda, AS | 1 |
| Moreira, FA | 1 |
| van Enkhuizen, J | 4 |
| Henry, BL | 1 |
| Minassian, A | 2 |
| Perry, W | 2 |
| Milienne-Petiot, M | 2 |
| Higa, KK | 1 |
| Geyer, MA | 5 |
| Young, JW | 5 |
| Queiroz, AI | 1 |
| de Araújo, MM | 1 |
| da Silva Araújo, T | 1 |
| de Souza, GC | 1 |
| Cavalcante, LM | 1 |
| de Jesus Souza Machado, M | 1 |
| de Lucena, DF | 1 |
| Quevedo, J | 1 |
| Macêdo, D | 1 |
| Goey, AK | 1 |
| Paulus, MP | 1 |
| Kooistra, K | 1 |
8 other studies available for vanoxerine and Bipolar Disorder
| Article | Year |
|---|---|
Assessing positive and negative valence systems to refine animal models of bipolar disorders: the example of GBR 12909-induced manic phenotype.
Topics: Animals; Bipolar Disorder; Mania; Mice; Models, Animal; Phenotype; Piperazines | 2022 |
Inhibition of the dopamine transporter as an animal model of bipolar disorder mania: Locomotor response, neuroimmunological profile and pharmacological modulation.
Topics: Animals; Antidepressive Agents; Aripiprazole; Bipolar Disorder; Brain; Cytokines; Disease Models, An | 2018 |
Reduced dopamine transporter functioning induces high-reward risk-preference consistent with bipolar disorder.
Topics: Adolescent; Adult; Animals; Bipolar Disorder; Conditioning, Operant; Decision Making; Dopamine Plasm | 2014 |
GBR 12909 administration as an animal model of bipolar mania: time course of behavioral, brain oxidative alterations and effect of mood stabilizing drugs.
Topics: Affect; Animals; Antimanic Agents; Bipolar Disorder; Brain; Disease Models, Animal; Dopamine Uptake | 2015 |
Modeling bipolar disorder in mice by increasing acetylcholine or dopamine: chronic lithium treats most, but not all features.
Topics: Acetylcholine; Animals; Antimanic Agents; Behavior, Animal; Bipolar Disorder; Cholinesterase Inhibit | 2015 |
GBR 12909 administration as a mouse model of bipolar disorder mania: mimicking quantitative assessment of manic behavior.
Topics: Animals; Behavior, Animal; Bipolar Disorder; Dextroamphetamine; Disease Models, Animal; Dopamine Pla | 2010 |
Differential effects of dopamine transporter inhibitors in the rodent Iowa gambling task: relevance to mania.
Topics: Amphetamine; Animals; Behavior, Animal; Benzhydryl Compounds; Bipolar Disorder; Choice Behavior; Con | 2013 |
Chronic valproate attenuates some, but not all, facets of mania-like behaviour in mice.
Topics: Analysis of Variance; Animals; Antimanic Agents; Bipolar Disorder; Disease Models, Animal; Dopamine | 2013 |