vanoxerine has been researched along with Atherosclerotic Parkinsonism in 3 studies
vanoxerine: structure given in first source
vanoxerine : An N-alkylpiperazine that consists of piperazine bearing 2-bis(4-fluorophenyl)methoxy]ethyl and 3-phenylpropyl groups at positions 1 and 4 respectively. Potent, competitive inhibitor of dopamine uptake (Ki = 1 nM for inhibition of striatal dopamine uptake). Has > 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigma ligand (IC50 = 48 nM). Centrally active following systemic administration.
| Excerpt | Relevance | Reference |
|---|---|---|
| " All betaCs and MPP(+) showed general cytotoxicity in parental HEK-293 cells after 72 h with half-maximal toxic concentrations (TC(50) values) in the upper micromolar range." | 1.32 | Dopamine transporter-mediated cytotoxicity of beta-carbolinium derivatives related to Parkinson's disease: relationship to transporter-dependent uptake. ( Beach, JW; Collins, MA; Gearhart, DA; Hwang, YI; Neafsey, EJ; Schwarz, J; Storch, A, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Storch, A | 1 |
| Hwang, YI | 1 |
| Gearhart, DA | 1 |
| Beach, JW | 1 |
| Neafsey, EJ | 1 |
| Collins, MA | 1 |
| Schwarz, J | 1 |
| Sotnikova, TD | 1 |
| Beaulieu, JM | 1 |
| Barak, LS | 1 |
| Wetsel, WC | 1 |
| Caron, MG | 1 |
| Gainetdinov, RR | 1 |
| Cragg, SJ | 1 |
| Clarke, DJ | 1 |
| Greenfield, SA | 1 |
3 other studies available for vanoxerine and Atherosclerotic Parkinsonism
| Article | Year |
|---|---|
Dopamine transporter-mediated cytotoxicity of beta-carbolinium derivatives related to Parkinson's disease: relationship to transporter-dependent uptake.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; 1-Methyl-4-phenylpyridinium; Carbolines; Cell Line; Ce | 2004 |
Dopamine-independent locomotor actions of amphetamines in a novel acute mouse model of Parkinson disease.
Topics: alpha-Methyltyrosine; Amphetamines; Animals; Antiparkinson Agents; Basal Ganglia; Blepharoptosis; Di | 2005 |
Real-time dynamics of dopamine released from neuronal transplants in experimental Parkinson's disease.
Topics: Animals; Brain Tissue Transplantation; Corpus Striatum; Dopamine; Dopamine Uptake Inhibitors; Electr | 2000 |