vanoxerine has been researched along with Ascorbic Acid Deficiency in 2 studies
vanoxerine: structure given in first source
vanoxerine : An N-alkylpiperazine that consists of piperazine bearing 2-bis(4-fluorophenyl)methoxy]ethyl and 3-phenylpropyl groups at positions 1 and 4 respectively. Potent, competitive inhibitor of dopamine uptake (Ki = 1 nM for inhibition of striatal dopamine uptake). Has > 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigma ligand (IC50 = 48 nM). Centrally active following systemic administration.
Ascorbic Acid Deficiency: A condition due to a dietary deficiency of ascorbic acid (vitamin C), characterized by malaise, lethargy, and weakness. As the disease progresses, joints, muscles, and subcutaneous tissues may become the sites of hemorrhage. Ascorbic acid deficiency frequently develops into SCURVY in young children fed unsupplemented cow's milk exclusively during their first year. It develops also commonly in chronic alcoholism. (Cecil Textbook of Medicine, 19th ed, p1177)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Schizophrenia is associated with a cerebral glutathione deficit, which may leave the brain susceptible to oxidants." | 1.32 | Low brain glutathione and ascorbic acid associated with dopamine uptake inhibition during rat's development induce long-term cognitive deficit: relevance to schizophrenia. ( Castagné, V; Cuenod, M; Do, KQ; Rougemont, M, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rougemont, M | 2 |
| Do, KQ | 2 |
| Castagné, V | 2 |
| Cuenod, M | 1 |
2 other studies available for vanoxerine and Ascorbic Acid Deficiency
| Article | Year |
|---|---|
New model of glutathione deficit during development: Effect on lipid peroxidation in the rat brain.
Topics: Animals; Ascorbic Acid Deficiency; Brain; Brain Chemistry; Buthionine Sulfoximine; Chromatography, H | 2002 |
Low brain glutathione and ascorbic acid associated with dopamine uptake inhibition during rat's development induce long-term cognitive deficit: relevance to schizophrenia.
Topics: Animals; Ascorbic Acid Deficiency; Body Weight; Brain; Brain Chemistry; Buthionine Sulfoximine; Cogn | 2004 |