vanoxerine has been researched along with Amphetamine-Related Disorders in 2 studies
vanoxerine: structure given in first source
vanoxerine : An N-alkylpiperazine that consists of piperazine bearing 2-bis(4-fluorophenyl)methoxy]ethyl and 3-phenylpropyl groups at positions 1 and 4 respectively. Potent, competitive inhibitor of dopamine uptake (Ki = 1 nM for inhibition of striatal dopamine uptake). Has > 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigma ligand (IC50 = 48 nM). Centrally active following systemic administration.
Amphetamine-Related Disorders: Disorders related or resulting from use of amphetamines.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Finally, the dopamine transporter inhibitor GBR 12909 completely prevented dopamine neurotoxicity caused by the malonate/MDMA combination and reversed the exacerbating toxic effects of malonate on MDMA-induced 5-HT depletion without significantly altering the hyperthermic response." | 1.33 | Studies on striatal neurotoxicity caused by the 3,4-methylenedioxymethamphetamine/ malonate combination: implications for serotonin/dopamine interactions. ( Aguirre, N; Goñi-Allo, B; Herv'as, I; Lasheras, B; Ramos, M, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Goñi-Allo, B | 1 |
| Ramos, M | 1 |
| Herv'as, I | 1 |
| Lasheras, B | 1 |
| Aguirre, N | 1 |
| Baumann, MH | 1 |
| Phillips, JM | 1 |
| Ayestas, MA | 1 |
| Ali, SF | 1 |
| Rice, KC | 1 |
| Rothman, RB | 1 |
2 other studies available for vanoxerine and Amphetamine-Related Disorders
| Article | Year |
|---|---|
Studies on striatal neurotoxicity caused by the 3,4-methylenedioxymethamphetamine/ malonate combination: implications for serotonin/dopamine interactions.
Topics: Amphetamine-Related Disorders; Animals; Body Temperature Regulation; Cell Survival; Corpus Striatum; | 2006 |
Preclinical evaluation of GBR12909 decanoate as a long-acting medication for methamphetamine dependence.
Topics: Amphetamine-Related Disorders; Animals; Binding Sites; Carrier Proteins; Dopamine; Dopamine Plasma M | 2002 |