vanoxerine and Aging
vanoxerine has been researched along with Aging in 6 studies
vanoxerine: structure given in first source
vanoxerine : An N-alkylpiperazine that consists of piperazine bearing 2-bis(4-fluorophenyl)methoxy]ethyl and 3-phenylpropyl groups at positions 1 and 4 respectively. Potent, competitive inhibitor of dopamine uptake (Ki = 1 nM for inhibition of striatal dopamine uptake). Has > 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigma ligand (IC50 = 48 nM). Centrally active following systemic administration.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
Research
Studies (6)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Smittkamp, S | 1 |
| Spalding, H | 1 |
| Zhang, H | 1 |
| Stanford, JA | 1 |
| Walker, QD | 1 |
| Morris, SE | 1 |
| Arrant, AE | 1 |
| Nagel, JM | 1 |
| Parylak, S | 1 |
| Zhou, G | 1 |
| Caster, JM | 1 |
| Kuhn, CM | 1 |
| Harada, N | 1 |
| Nishiyama, S | 1 |
| Satoh, K | 1 |
| Fukumoto, D | 1 |
| Kakiuchi, T | 1 |
| Tsukada, H | 1 |
| Castagné, V | 1 |
| Cuénod, M | 1 |
| Do, KQ | 1 |
| Grondin, R | 1 |
| Zhang, Z | 1 |
| Gerhardt, GA | 1 |
| Gash, DM | 1 |
| Shimizu, I | 1 |
| Prasad, C | 1 |
Other Studies
6 other studies available for vanoxerine and Aging
| Article | Year |
|---|---|
Differential effects of amphetamine and GBR-12909 on orolingual motor function in young vs aged F344/BN rats.
Topics: Age Factors; Aging; Amphetamine; Animals; Behavior, Animal; Male; Motor Activity; Piperazines; Rats; | 2014 |
Dopamine uptake inhibitors but not dopamine releasers induce greater increases in motor behavior and extracellular dopamine in adolescent rats than in adult male rats.
Topics: Aging; Amphetamines; Animals; Behavior, Animal; Brain Chemistry; Dopamine; Dopamine Uptake Inhibitor | 2010 |
Age-related changes in the striatal dopaminergic system in the living brain: a multiparametric PET study in conscious monkeys.
Topics: Aging; Animals; Benzazepines; Cocaine; Corpus Striatum; Dopamine; Dopamine Uptake Inhibitors; Dose-R | 2002 |
An animal model with relevance to schizophrenia: sex-dependent cognitive deficits in osteogenic disorder-Shionogi rats induced by glutathione synthesis and dopamine uptake inhibition during development.
Topics: Aging; Animals; Animals, Newborn; Behavior, Animal; Body Weight; Brain Chemistry; Buthionine Sulfoxi | 2004 |
Dopaminergic therapy improves upper limb motor performance in aged rhesus monkeys.
Topics: Aging; Animals; Arm; Dopamine; Dopamine Uptake Inhibitors; Female; Macaca mulatta; Movement; Neostri | 2000 |
Relationship between [3H]mazindol binding to dopamine uptake sites and [3H]dopamine uptake in rat striatum during aging.
Topics: Aging; Animals; Carrier Proteins; Cell Membrane; Corpus Striatum; Dopamine; Dopamine Antagonists; Do | 1991 |