Page last updated: 2024-10-27

vanoxerine and Aging

vanoxerine has been researched along with Aging in 6 studies

vanoxerine: structure given in first source
vanoxerine : An N-alkylpiperazine that consists of piperazine bearing 2-bis(4-fluorophenyl)methoxy]ethyl and 3-phenylpropyl groups at positions 1 and 4 respectively. Potent, competitive inhibitor of dopamine uptake (Ki = 1 nM for inhibition of striatal dopamine uptake). Has > 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigma ligand (IC50 = 48 nM). Centrally active following systemic administration.

Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (16.67)18.2507
2000's3 (50.00)29.6817
2010's2 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Smittkamp, S1
Spalding, H1
Zhang, H1
Stanford, JA1
Walker, QD1
Morris, SE1
Arrant, AE1
Nagel, JM1
Parylak, S1
Zhou, G1
Caster, JM1
Kuhn, CM1
Harada, N1
Nishiyama, S1
Satoh, K1
Fukumoto, D1
Kakiuchi, T1
Tsukada, H1
Castagné, V1
Cuénod, M1
Do, KQ1
Grondin, R1
Zhang, Z1
Gerhardt, GA1
Gash, DM1
Shimizu, I1
Prasad, C1

Other Studies

6 other studies available for vanoxerine and Aging

ArticleYear
Differential effects of amphetamine and GBR-12909 on orolingual motor function in young vs aged F344/BN rats.
    Psychopharmacology, 2014, Volume: 231, Issue:24

    Topics: Age Factors; Aging; Amphetamine; Animals; Behavior, Animal; Male; Motor Activity; Piperazines; Rats;

2014
Dopamine uptake inhibitors but not dopamine releasers induce greater increases in motor behavior and extracellular dopamine in adolescent rats than in adult male rats.
    The Journal of pharmacology and experimental therapeutics, 2010, Volume: 335, Issue:1

    Topics: Aging; Amphetamines; Animals; Behavior, Animal; Brain Chemistry; Dopamine; Dopamine Uptake Inhibitor

2010
Age-related changes in the striatal dopaminergic system in the living brain: a multiparametric PET study in conscious monkeys.
    Synapse (New York, N.Y.), 2002, Volume: 45, Issue:1

    Topics: Aging; Animals; Benzazepines; Cocaine; Corpus Striatum; Dopamine; Dopamine Uptake Inhibitors; Dose-R

2002
An animal model with relevance to schizophrenia: sex-dependent cognitive deficits in osteogenic disorder-Shionogi rats induced by glutathione synthesis and dopamine uptake inhibition during development.
    Neuroscience, 2004, Volume: 123, Issue:4

    Topics: Aging; Animals; Animals, Newborn; Behavior, Animal; Body Weight; Brain Chemistry; Buthionine Sulfoxi

2004
Dopaminergic therapy improves upper limb motor performance in aged rhesus monkeys.
    Annals of neurology, 2000, Volume: 48, Issue:2

    Topics: Aging; Animals; Arm; Dopamine; Dopamine Uptake Inhibitors; Female; Macaca mulatta; Movement; Neostri

2000
Relationship between [3H]mazindol binding to dopamine uptake sites and [3H]dopamine uptake in rat striatum during aging.
    Journal of neurochemistry, 1991, Volume: 56, Issue:2

    Topics: Aging; Animals; Carrier Proteins; Cell Membrane; Corpus Striatum; Dopamine; Dopamine Antagonists; Do

1991