vanoxerine has been researched along with Acute Disease in 2 studies
vanoxerine: structure given in first source
vanoxerine : An N-alkylpiperazine that consists of piperazine bearing 2-bis(4-fluorophenyl)methoxy]ethyl and 3-phenylpropyl groups at positions 1 and 4 respectively. Potent, competitive inhibitor of dopamine uptake (Ki = 1 nM for inhibition of striatal dopamine uptake). Has > 100-fold lower affinity for the noradrenalin and 5-HT uptake carriers. Also a potent sigma ligand (IC50 = 48 nM). Centrally active following systemic administration.
Acute Disease: Disease having a short and relatively severe course.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Initially, dose-response experiments were performed with intrahippocampal perfusions of GBR-12909 and citalopram, respectively, selective dopamine and serotonin re-uptake blockers." | 5.32 | Anticonvulsant action of GBR-12909 and citalopram against acute experimentally induced limbic seizures. ( Clinckers, R; Ebinger, G; Meurs, A; Michotte, Y; Smolders, I, 2004) |
| " Initially, dose-response experiments were performed with intrahippocampal perfusions of GBR-12909 and citalopram, respectively, selective dopamine and serotonin re-uptake blockers." | 1.32 | Anticonvulsant action of GBR-12909 and citalopram against acute experimentally induced limbic seizures. ( Clinckers, R; Ebinger, G; Meurs, A; Michotte, Y; Smolders, I, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Clinckers, R | 1 |
| Smolders, I | 1 |
| Meurs, A | 1 |
| Ebinger, G | 1 |
| Michotte, Y | 1 |
| Mechan, AO | 1 |
| Esteban, B | 1 |
| O'Shea, E | 1 |
| Elliott, JM | 1 |
| Colado, MI | 1 |
| Green, AR | 1 |
2 other studies available for vanoxerine and Acute Disease
| Article | Year |
|---|---|
Anticonvulsant action of GBR-12909 and citalopram against acute experimentally induced limbic seizures.
Topics: Acute Disease; Animals; Anticonvulsants; Biogenic Monoamines; Citalopram; Dopamine; Dopamine Antagon | 2004 |
The pharmacology of the acute hyperthermic response that follows administration of 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') to rats.
Topics: 3,4-Methylenedioxyamphetamine; Acute Disease; Animals; Benzazepines; Body Temperature; Corpus Striat | 2002 |