vanilmandelic acid has been researched along with Parkinson Disease in 25 studies
Vanilmandelic Acid: A 3-O-methyl ether of 3,4-dihydroxymandelic acid. It is an end-stage metabolite of CATECHOLAMINES; EPINEPHRINE; and NOREPINEPHRINE.
vanillylmandelic acid : An aromatic ether that is the 3-O-methyl ether of 3,4-dihydroxymandelic acid.
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Gas-liquid chromatographic methods were used to measure urinary acidic and alcoholic metabolites of L-DOPA, which had been administered in high oral dosage to patients with postencephalitic and idiopathic Parkinsonism." | 2.63 | The metabolism of orally administered L-Dopa in Parkinsonism. ( Calne, DB; Karoum, F; Ruthven, CR; Sandler, M, 1969) |
| "Levodopa induced an increase of about 400 fold in urinary DA; DOPAC was increased about 300 fold, 3-MT only about 70 fold, but HVA about 300 fold." | 1.25 | Urinary excretion of monoamines and their metabolites in patients with Parkinson's disease. Response to long-term treatment with levodopa alone or in combination with a dopa decarboxylase inhibitor and clinical correlations. ( Rinne, UK; Siirtola, T; Sonninen, V, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (84.00) | 18.7374 |
| 1990's | 3 (12.00) | 18.2507 |
| 2000's | 1 (4.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jähnel, M | 1 |
| Factor, SA | 1 |
| Schneider, AS | 1 |
| Peyrin, L | 1 |
| Cottet-Emard, JM | 1 |
| Claustre, B | 1 |
| Stoica, E | 1 |
| Enulescu, O | 1 |
| Rinne, UK | 4 |
| Siirtola, T | 2 |
| Sonninen, V | 4 |
| Ikarashi, Y | 1 |
| Blank, CL | 1 |
| Itoh, K | 1 |
| Satoh, H | 1 |
| Inoue, HK | 1 |
| Maruyama, Y | 1 |
| Kayser, S | 1 |
| Richter, M | 1 |
| Quinn, N | 1 |
| Carruthers, M | 1 |
| Sirtola, T | 1 |
| Paddison, RM | 1 |
| Griffith, RP | 1 |
| Sharpless, NS | 1 |
| Tyce, GM | 1 |
| Muenter, MD | 1 |
| Dinapoli, RP | 1 |
| Ambrozi, L | 1 |
| Birkmayer, W | 1 |
| Danielczyk, W | 1 |
| Neumayer, E | 1 |
| Riederer, P | 1 |
| Matlina, ESh | 1 |
| Kandel', EI | 1 |
| Vasil'ev, VN | 1 |
| Iadgarov, IS | 1 |
| Bol'shakova, TD | 1 |
| Ericsson, AD | 3 |
| McCann, D | 1 |
| Sharpless, N | 1 |
| Reveno, W | 1 |
| Hinterberger, H | 2 |
| Andrews, CJ | 1 |
| Jequier, E | 1 |
| Dufresne, JJ | 1 |
| Fukaya, J | 1 |
| Imai, K | 1 |
| Tamura, Z | 1 |
| Szpunar, WE | 1 |
| McCann, DS | 1 |
| Wertman, BG | 1 |
| Calne, DB | 1 |
| Karoum, F | 1 |
| Ruthven, CR | 1 |
| Sandler, M | 1 |
| Uono, M | 1 |
| Tanabe, H | 1 |
| Yano, Y | 1 |
| Nakao, K | 1 |
| Routh, JI | 1 |
| Bannow, RE | 1 |
| Fincham, RW | 1 |
| Stoll, JL | 1 |
1 review available for vanilmandelic acid and Parkinson Disease
| Article | Year |
|---|---|
[Biochemical aspects of human behaviour (author's transl)].
Topics: Animals; Athetosis; Behavior; Behavior, Animal; Biogenic Amines; Brain; Brain Chemistry; Catecholami | 1973 |
3 trials available for vanilmandelic acid and Parkinson Disease
| Article | Year |
|---|---|
Treatment of Parkinson's disease with L-DOPA and decarboxylase inhibitor.
Topics: Biopsy; Carboxy-Lyases; Clinical Trials as Topic; Dihydroxyphenylalanine; Drug Combinations; Drug Sy | 1972 |
Metabolism and clinical assessment of L-dopa in parkinsonism.
Topics: Adult; Aged; Clinical Trials as Topic; Dihydroxyphenylalanine; Female; Humans; Male; Middle Aged; Pa | 1970 |
The metabolism of orally administered L-Dopa in Parkinsonism.
Topics: Chromatography, Gas; Dihydroxyphenylalanine; Female; Humans; Male; Norepinephrine; Parkinson Disease | 1969 |
21 other studies available for vanilmandelic acid and Parkinson Disease
| Article | Year |
|---|---|
[Pseudopheochromocytoma in Parkinson disease and depression].
Topics: Adrenal Gland Neoplasms; Antidepressive Agents; Antiparkinson Agents; Catecholamines; Depressive Dis | 2003 |
Peripheral catecholamine output in Parkinson's disease: effects of drug treatment.
Topics: Adrenal Medulla; Aged; Carbidopa; Catecholamines; Corpus Striatum; Epinephrine; Female; Humans; Levo | 1995 |
Studies on urinary DOPAC in man by means of a sensitive automated procedure.
Topics: 3,4-Dihydroxyphenylacetic Acid; Addison Disease; Adrenal Gland Neoplasms; Adult; Aged; Autoanalysis; | 1978 |
Abnormal epinephrine urinary excretion in Parkinsonians: correction of the disorder by levodopa administration.
Topics: Adult; Age Factors; Aged; Epinephrine; Female; Humans; Levodopa; Male; Middle Aged; Norepinephrine; | 1978 |
L-deprenyl treatment of on-off phenomena in Parkinson's disease.
Topics: Aged; Benserazide; Dopamine; Drug Therapy, Combination; Female; Homovanillic Acid; Humans; Hydroxyin | 1978 |
Urinary excretion of monoamines and their metabolites in patients with Parkinson's disease. Response to long-term treatment with levodopa alone or in combination with a dopa decarboxylase inhibitor and clinical correlations.
Topics: 3,4-Dihydroxyphenylacetic Acid; Benserazide; Biogenic Amines; Dopamine; Female; Homovanillic Acid; H | 1975 |
[Development of a liquid chromatography/multiple electrochemical detector (LCMC) and its application in neuroscience].
Topics: Animals; Brain Chemistry; Chromatography, High Pressure Liquid; Electrochemistry; Male; Methoxyhydro | 1991 |
[Headache, hypertension].
Topics: Adrenal Gland Neoplasms; Aged; Diagnosis, Differential; Female; Headache; Humans; Hypertension; Levo | 1991 |
False positive diagnosis of phaeochromocytoma in a patient with Parkinson's disease receiving levodopa.
Topics: Adrenal Gland Neoplasms; Aged; Carbidopa; Diagnostic Errors; Drug Combinations; Female; Humans; Levo | 1988 |
Occurrence of Parkinson's disease in black patients at Charity Hospital in New Orleans.
Topics: Adult; Age Factors; Aged; Arylsulfonates; Black People; Brain; Female; Homovanillic Acid; Humans; Lo | 1974 |
Dopa, 3-O-methyldopa, and metabolites in urine during oral L-3-O-methyldopa therapy.
Topics: Administration, Oral; Autoanalysis; Catecholamines; Dealkylation; Decarboxylation; Dihydroxyphenylal | 1974 |
[The effect of alpha-DOPA on the dynamics of urinary excretion of DOPA, catecholamines and their metabolites in healthy subjects and in patients with parkinsonism].
Topics: Adult; Aged; Dihydroxyphenylalanine; Dopamine; Epinephrine; Humans; Middle Aged; Parkinson Disease; | 1973 |
Catecholamine metabolism during oral administration of levodopa.
Topics: Aged; Catecholamines; Dihydroxyphenylalanine; Dopamine; Female; Humans; Hydroxyindoleacetic Acid; Ma | 1972 |
Biochemical investigations in patients with Parkinson's disease treated with L-dopa.
Topics: Adult; Aged; Basal Ganglia; Dihydroxyphenylalanine; Dopamine; Female; Humans; Male; Middle Aged; Par | 1972 |
A simple and rapid gas chromatography for determining 3,4-dihydroxyphenylacetic acid and 3-methoxy-4-hydroxyphenylacetic acid in urine from patients with parkinsonism treated with L-3,4-dihydroxyphenylalanine.
Topics: Chromatography, Gas; Dihydroxyphenylalanine; Hippurates; Humans; Kinetics; Mandelic Acids; Methods; | 1971 |
Tyrosine metabolism: urinary excretion studies in Parkinsonism.
Topics: Body Weight; Chromatography, Gas; Chromatography, Ion Exchange; Chromatography, Thin Layer; Colorime | 1971 |
Sensitivity studies of L-dopa metabolites in reserpinized rats and their clinical significance.
Topics: Animals; Brain; Catechols; Dihydroxyphenylalanine; Female; Humans; Male; Mandelic Acids; Middle Aged | 1971 |
The biochemistry of catecholamines in relation to Parkinson's disease.
Topics: Catecholamines; Dihydroxyphenylalanine; Dopamine; Epinephrine; Humans; Norepinephrine; Parkinson Dis | 1971 |
Catecholamines in Parkinson's disease.
Topics: Catecholamines; Humans; Parkinson Disease; Phenylacetates; Vanilmandelic Acid | 1970 |
[Treatment of Parkinsonism with L-dopa--with special reference to clinical effects, side effects and urinary metabolites of catecholamines].
Topics: Adult; Aged; Dihydroxyphenylalanine; Dopamine; Female; Humans; Male; Middle Aged; Parkinson Disease; | 1970 |
Excretion of L-dopa and its metabolites in urine of Parkinson's disease patients receiving L-dopa therapy.
Topics: Aged; Aluminum; Chromatography; Chromatography, Ion Exchange; Colorimetry; Dihydroxyphenylalanine; D | 1971 |