vanillin has been researched along with HbS Disease in 11 studies
Vanilla: A plant genus of the family ORCHIDACEAE that is the source of the familiar flavoring used in foods and medicines (FLAVORING AGENTS).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Vanillin has previously been studied clinically as an antisickling agent to treat sickle-cell disease." | 1.37 | Crystallographic analysis of human hemoglobin elucidates the structural basis of the potent and dual antisickling activity of pyridyl derivatives of vanillin. ( Abdulmalik, O; Abraham, DJ; Asakura, T; Chen, Q; Danso-Danquah, R; Eseonu, DN; Ghatge, MS; Musayev, FN; Nnamani, I; Parikh, A; Safo, MK; Venitz, J; Yang, J, 2011) |
| "Vanillin has no adverse effects on cell ion or water content." | 1.28 | Vanillin, a potential agent for the treatment of sickle cell anemia. ( Abraham, DJ; Mehanna, AS; Orringer, EP; Thomas, RP; Whitney, J; Wireko, FC, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (18.18) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 5 (45.45) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Safo, MK | 4 |
| Abdulmalik, O | 5 |
| Danso-Danquah, R | 2 |
| Burnett, JC | 1 |
| Nokuri, S | 1 |
| Joshi, GS | 1 |
| Musayev, FN | 4 |
| Asakura, T | 3 |
| Abraham, DJ | 3 |
| Pagare, PP | 2 |
| Ghatge, MS | 3 |
| Deshpande, TM | 2 |
| Chen, Q | 4 |
| Braxton, C | 1 |
| Kim, S | 1 |
| Venitz, J | 3 |
| Zhang, Y | 2 |
| Enakaya, NA | 1 |
| Jefferson, A | 1 |
| Chew-Martinez, D | 1 |
| Matthews, JS | 1 |
| Richter-Addo, GB | 1 |
| Castan, L | 1 |
| Del Toro, G | 1 |
| Fernández, AA | 1 |
| González, M | 1 |
| Ortíz, E | 1 |
| Lobo, D | 1 |
| Parikh, A | 1 |
| Yang, J | 1 |
| Nnamani, I | 1 |
| Eseonu, DN | 1 |
| Zhang, C | 1 |
| Li, X | 1 |
| Lian, L | 1 |
| Vassilev, V | 1 |
| Lai, CS | 1 |
| García, AF | 1 |
| Cabal, C | 1 |
| Losada, J | 1 |
| Alvarez, E | 1 |
| Soler, C | 1 |
| Otero, J | 1 |
| Aruoma, OI | 1 |
| Mehanna, AS | 1 |
| Wireko, FC | 1 |
| Whitney, J | 1 |
| Thomas, RP | 1 |
| Orringer, EP | 1 |
1 trial available for vanillin and HbS Disease
| Article | Year |
|---|---|
In vivo action of Vanillin on delay time determined by magnetic relaxation.
Topics: Administration, Oral; Adolescent; Adult; Anemia, Sickle Cell; Antioxidants; Benzaldehydes; Double-Bl | 2005 |
10 other studies available for vanillin and HbS Disease
| Article | Year |
|---|---|
Structural basis for the potent antisickling effect of a novel class of five-membered heterocyclic aldehydic compounds.
Topics: Aldehydes; Anemia, Sickle Cell; Antisickling Agents; Binding Sites; Chromatography, High Pressure Li | 2004 |
Rational design of pyridyl derivatives of vanillin for the treatment of sickle cell disease.
Topics: Anemia, Sickle Cell; Antisickling Agents; Benzaldehydes; Blood; Crystallography, X-Ray; Drug Design; | 2018 |
Design, Synthesis, and Evaluation of Allosteric Effectors for Hemoglobin.
Topics: Aldehydes; Anemia, Sickle Cell; Erythrocytes; Hemoglobin, Sickle; Hemoglobins; Humans; Oxygen | 2023 |
Rational modification of vanillin derivatives to stereospecifically destabilize sickle hemoglobin polymer formation.
Topics: Anemia, Sickle Cell; Antisickling Agents; Benzaldehydes; Crystallography, X-Ray; Hemoglobin, Sickle; | 2018 |
A structure-guided approach to ameliorate sickle cell disease.
Topics: Anemia, Sickle Cell; Anticonvulsants; Antisickling Agents; Benzaldehydes; Crystallography, X-Ray; Er | 2018 |
Biological activity of liposomal vanillin.
Topics: Anemia, Sickle Cell; Antioxidants; Antisickling Agents; Benzaldehydes; Chemistry, Pharmaceutical; Dr | 2013 |
Crystallographic analysis of human hemoglobin elucidates the structural basis of the potent and dual antisickling activity of pyridyl derivatives of vanillin.
Topics: Anemia, Sickle Cell; Antisickling Agents; Benzaldehydes; Crystallization; Crystallography, X-Ray; He | 2011 |
Anti-sickling effect of MX-1520, a prodrug of vanillin: an in vivo study using rodents.
Topics: Anemia, Sickle Cell; Animals; Benzaldehydes; Biological Availability; Food Additives; Hypoxia; Injec | 2004 |
Dietary management of sickle cell anaemia with vanillin.
Topics: Anemia, Sickle Cell; Antioxidants; Benzaldehydes; Flavoring Agents; Humans | 1992 |
Vanillin, a potential agent for the treatment of sickle cell anemia.
Topics: Anemia, Sickle Cell; Animals; Anticonvulsants; Benzaldehydes; Biological Transport; Chromatography, | 1991 |