valproic acid has been researched along with von Willebrand Diseases in 6 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
von Willebrand Diseases: Group of hemorrhagic disorders in which the VON WILLEBRAND FACTOR is either quantitatively or qualitatively abnormal. They are usually inherited as an autosomal dominant trait though rare kindreds are autosomal recessive. Symptoms vary depending on severity and disease type but may include prolonged bleeding time, deficiency of factor VIII, and impaired platelet adhesion.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Valproic acid is commonly used in the management of childhood epilepsy." | 3.71 | Coagulation abnormalities and acquired von Willebrand's disease type 1 in children receiving valproic acid. ( Kavakli, K; Serdaroglu, G; Tekgül, H; Tütüncüoglu, S, 2002) |
| "Fibrinogen was significantly reduced." | 2.73 | High incidence of vaproate-induced coagulation disorders in children receiving valproic acid: a prospective study. ( Dempfle, CE; Gerstner, T; Keller, A; Koenig, S; Longin, E; Teich, M, 2008) |
| "Valproic acid (VPA) is an antiepileptic drug (AED) commonly used for generalized and focal epilepsies." | 1.33 | Valproate-associated coagulopathies are frequent and variable in children. ( Bell, N; Brand, J; Dempfle, CE; Gerstner, T; König, S; Longin, E; Teich, M, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 4 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Koenig, S | 1 |
| Gerstner, T | 2 |
| Keller, A | 1 |
| Teich, M | 2 |
| Longin, E | 2 |
| Dempfle, CE | 2 |
| Eberl, W | 1 |
| Budde, U | 1 |
| Bentele, K | 1 |
| Christen, HJ | 1 |
| Knapp, R | 1 |
| Mey, A | 1 |
| Schneppenheim, R | 1 |
| Bell, N | 1 |
| Brand, J | 1 |
| König, S | 1 |
| Gil-Fernández, JJ | 1 |
| Serdaroglu, G | 1 |
| Tütüncüoglu, S | 1 |
| Kavakli, K | 1 |
| Tekgül, H | 1 |
| Kreuz, W | 1 |
| Linde, R | 1 |
| Funk, M | 1 |
| Meyer-Schrod, R | 1 |
| Föll, E | 1 |
| Nowak-Göttl, U | 1 |
| Jacobi, G | 1 |
| Vigh, Z | 1 |
| Scharrer, I | 1 |
1 trial available for valproic acid and von Willebrand Diseases
| Article | Year |
|---|---|
High incidence of vaproate-induced coagulation disorders in children receiving valproic acid: a prospective study.
Topics: Anticonvulsants; Blood Platelets; Child; Child, Preschool; Factor XIII; Female; Fibrinogen; Humans; | 2008 |
5 other studies available for valproic acid and von Willebrand Diseases
| Article | Year |
|---|---|
Acquired von Willebrand syndrome as side effect of valproic acid therapy in children is rare.
Topics: Anticonvulsants; Child; Factor VIII; Humans; Seizures; Valproic Acid; von Willebrand Diseases; von W | 2009 |
Valproate-associated coagulopathies are frequent and variable in children.
Topics: Age Factors; Anticonvulsants; Blood Coagulation Tests; Child; Coagulation Protein Disorders; Epileps | 2006 |
Analysis of surgical blood loss and number of blood transfusions after temporal lobe resection performed in adults with epilepsy receiving valproate (VPA) in the immediate preoperative period.
Topics: Adolescent; Adult; Aged; Bleeding Time; Blood Loss, Surgical; Blood Transfusion; Epilepsy, Temporal | 1997 |
Coagulation abnormalities and acquired von Willebrand's disease type 1 in children receiving valproic acid.
Topics: Adolescent; Anticonvulsants; Antigens; Blood Coagulation Tests; Child; Child, Preschool; Dose-Respon | 2002 |
Induction of von Willebrand disease type I by valproic acid.
Topics: Adolescent; Child; Child, Preschool; Factor VIII; Female; Humans; Infant; Male; Valproic Acid; von W | 1990 |