valproic acid has been researched along with Wolfram Syndrome in 3 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Wolfram Syndrome: A hereditary condition characterized by multiple symptoms including those of DIABETES INSIPIDUS; DIABETES MELLITUS; OPTIC ATROPHY; and DEAFNESS. This syndrome is also known as DIDMOAD (first letter of each word) and is usually associated with VASOPRESSIN deficiency. It is caused by mutations in gene WFS1 encoding wolframin, a 100-kDa transmembrane protein.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 3 (100.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pourtoy-Brasselet, S | 1 |
| Sciauvaud, A | 1 |
| Boza-Moran, MG | 1 |
| Cailleret, M | 1 |
| Jarrige, M | 1 |
| Polvèche, H | 1 |
| Polentes, J | 1 |
| Chevet, E | 1 |
| Martinat, C | 1 |
| Peschanski, M | 1 |
| Aubry, L | 1 |
| Punapart, M | 1 |
| Seppa, K | 1 |
| Jagomäe, T | 1 |
| Liiv, M | 1 |
| Reimets, R | 1 |
| Kirillov, S | 1 |
| Kaasik, A | 1 |
| Moons, L | 1 |
| De Groef, L | 1 |
| Terasmaa, A | 1 |
| Vasar, E | 1 |
| Plaas, M | 1 |
| Batjargal, K | 1 |
| Tajima, T | 1 |
| Jimbo, EF | 1 |
| Yamagata, T | 1 |
3 other studies available for valproic acid and Wolfram Syndrome
| Article | Year |
|---|---|
Human iPSC-derived neurons reveal early developmental alteration of neurite outgrowth in the late-occurring neurodegenerative Wolfram syndrome.
Topics: Age of Onset; Case-Control Studies; CRISPR-Cas Systems; Endoplasmic Reticulum Stress; Gene Expressio | 2021 |
The Expression of RAAS Key Receptors,
Topics: Aldosterone; Animals; Calmodulin-Binding Proteins; Cells, Cultured; Disease Models, Animal; Down-Reg | 2021 |
Effect of 4-phenylbutyrate and valproate on dominant mutations of WFS1 gene in Wolfram syndrome.
Topics: Animals; Apoptosis; Cells, Cultured; Endoplasmic Reticulum Stress; Gene Expression Regulation; Genes | 2020 |