valproic acid has been researched along with Weight Loss in 6 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Weight Loss: Decrease in existing BODY WEIGHT.
| Excerpt | Relevance | Reference |
|---|---|---|
| "l-carnitine had no effect on mean weight loss compared with placebo (-1." | 9.12 | Carnitine does not improve weight loss outcomes in valproate-treated bipolar patients consuming an energy-restricted, low-fat diet. ( Elmslie, JL; Hunt, PJ; Joyce, PR; Mann, JI; Porter, RJ, 2006) |
| "The interaction between clearance of phenytoin, valproic acid, phenobarbital and carbamazepine, and changes in body weight was determined in a 19-year-old obese woman with epilepsy (body weight 93 kg, BMI 36." | 7.69 | Clearance of phenytoin and valproic acid is affected by a small body weight reduction in an epileptic obese patient: a case study. ( Ashikari, Y; Chiba, S; Kodama, Y; Kuranari, M; Sakata, T; Takeyama, M, 1996) |
| "Valproic acid (VPA) is a short-chain branched fatty with anti-inflammatory, neuro-protective and axon-remodeling effects." | 5.35 | Valproic acid attenuates inflammation in experimental autoimmune neuritis. ( Fauser, U; Schluesener, HJ; Zhang, Z; Zhang, ZY, 2008) |
| "l-carnitine had no effect on mean weight loss compared with placebo (-1." | 5.12 | Carnitine does not improve weight loss outcomes in valproate-treated bipolar patients consuming an energy-restricted, low-fat diet. ( Elmslie, JL; Hunt, PJ; Joyce, PR; Mann, JI; Porter, RJ, 2006) |
| "The interaction between clearance of phenytoin, valproic acid, phenobarbital and carbamazepine, and changes in body weight was determined in a 19-year-old obese woman with epilepsy (body weight 93 kg, BMI 36." | 3.69 | Clearance of phenytoin and valproic acid is affected by a small body weight reduction in an epileptic obese patient: a case study. ( Ashikari, Y; Chiba, S; Kodama, Y; Kuranari, M; Sakata, T; Takeyama, M, 1996) |
| "He was diagnosed with type 2 diabetes mellitus, started treatment with empagliflozin, and his body weight decreased gradually." | 1.56 | Valproate intoxication in a patient with bipolar I disorder due to SGLT2 inhibitor-induced weight reduction. ( Miyauchi, T, 2020) |
| "Valproic acid (VPA) is a short-chain branched fatty with anti-inflammatory, neuro-protective and axon-remodeling effects." | 1.35 | Valproic acid attenuates inflammation in experimental autoimmune neuritis. ( Fauser, U; Schluesener, HJ; Zhang, Z; Zhang, ZY, 2008) |
| "Drug-induced weight gain is a serious side effect of many commonly used drugs leading to noncompliance with therapy and to exacerbation of comorbid conditions related to obesity." | 1.33 | Drug-induced weight gain. ( Apovian, CM; Ness-Abramof, R, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 4 (66.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Miyauchi, T | 1 |
| Jackson, R | 1 |
| Toubia, N | 1 |
| Dhaliwal, G | 1 |
| Bottomley, SS | 1 |
| Bronze, MS | 1 |
| Zhang, Z | 1 |
| Zhang, ZY | 1 |
| Fauser, U | 1 |
| Schluesener, HJ | 1 |
| Ness-Abramof, R | 1 |
| Apovian, CM | 1 |
| Elmslie, JL | 1 |
| Porter, RJ | 1 |
| Joyce, PR | 1 |
| Hunt, PJ | 1 |
| Mann, JI | 1 |
| Kuranari, M | 1 |
| Chiba, S | 1 |
| Ashikari, Y | 1 |
| Kodama, Y | 1 |
| Sakata, T | 1 |
| Takeyama, M | 1 |
1 trial available for valproic acid and Weight Loss
| Article | Year |
|---|---|
Carnitine does not improve weight loss outcomes in valproate-treated bipolar patients consuming an energy-restricted, low-fat diet.
Topics: Adult; Anticonvulsants; Bipolar Disorder; Body Mass Index; Carnitine; Diet, Fat-Restricted; Diet, Re | 2006 |
5 other studies available for valproic acid and Weight Loss
| Article | Year |
|---|---|
Valproate intoxication in a patient with bipolar I disorder due to SGLT2 inhibitor-induced weight reduction.
Topics: Aged; Antimanic Agents; Benzhydryl Compounds; Bipolar Disorder; Diabetes Mellitus, Type 2; Drug Inte | 2020 |
A confusing case of confusion. Acute porphyrias.
Topics: Acidosis, Lactic; Acute Disease; Anticonvulsants; Brain; Confusion; Diagnosis, Differential; Diet, R | 2008 |
Valproic acid attenuates inflammation in experimental autoimmune neuritis.
Topics: Animals; Cell Count; Cytokines; Forkhead Transcription Factors; Gene Expression Profiling; Inflammat | 2008 |
Drug-induced weight gain.
Topics: Anticonvulsants; Antipsychotic Agents; Humans; Obesity; Psychotropic Drugs; Risperidone; Valproic Ac | 2005 |
Clearance of phenytoin and valproic acid is affected by a small body weight reduction in an epileptic obese patient: a case study.
Topics: Adult; Anticonvulsants; Carbamazepine; Epilepsy; Female; Half-Life; Humans; Metabolic Clearance Rate | 1996 |