valproic acid has been researched along with Ureteral Obstruction in 2 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Ureteral Obstruction: Blockage in any part of the URETER causing obstruction of urine flow from the kidney to the URINARY BLADDER. The obstruction may be congenital, acquired, unilateral, bilateral, complete, partial, acute, or chronic. Depending on the degree and duration of the obstruction, clinical features vary greatly such as HYDRONEPHROSIS and obstructive nephropathy.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Renal fibrosis is a common pathological feature of the progression of chronic kidney disease." | 5.46 | Valproic acid attenuates renal fibrosis through the induction of autophagy. ( Doi, S; Doi, T; Kawaoka, K; Masaki, T; Nakashima, A; Ueno, T; Yamada, K, 2017) |
| "Valproic acid (VPA) has anticancer activity through regulation of cell differentiation and apoptosis via inhibition of histone deacetylase (HDAC) activity and is considered a class I HDAC inhibitor." | 1.48 | Inhibition of histone deacetylase 1 ameliorates renal tubulointerstitial fibrosis via modulation of inflammation and extracellular matrix gene transcription in mice. ( Kang, KP; Kim, D; Kim, W; Lee, S; Nguyễn-Thanh, T; Park, SK, 2018) |
| "Renal fibrosis is a common pathological feature of the progression of chronic kidney disease." | 1.46 | Valproic acid attenuates renal fibrosis through the induction of autophagy. ( Doi, S; Doi, T; Kawaoka, K; Masaki, T; Nakashima, A; Ueno, T; Yamada, K, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nguyễn-Thanh, T | 1 |
| Kim, D | 1 |
| Lee, S | 1 |
| Kim, W | 1 |
| Park, SK | 1 |
| Kang, KP | 1 |
| Kawaoka, K | 1 |
| Doi, S | 1 |
| Nakashima, A | 1 |
| Yamada, K | 1 |
| Ueno, T | 1 |
| Doi, T | 1 |
| Masaki, T | 1 |
2 other studies available for valproic acid and Ureteral Obstruction
| Article | Year |
|---|---|
Inhibition of histone deacetylase 1 ameliorates renal tubulointerstitial fibrosis via modulation of inflammation and extracellular matrix gene transcription in mice.
Topics: Animals; Cell Proliferation; Extracellular Matrix Proteins; Fibrosis; Histone Deacetylase 1; Histone | 2018 |
Valproic acid attenuates renal fibrosis through the induction of autophagy.
Topics: Actins; Adenine; Animals; Autophagy; Cell Line; Collagen Type I; Cytoprotection; Disease Models, Ani | 2017 |