valproic acid has been researched along with Tuberous Sclerosis in 4 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Tuberous Sclerosis: Autosomal dominant neurocutaneous syndrome classically characterized by MENTAL RETARDATION; EPILEPSY; and skin lesions (e.g., adenoma sebaceum and hypomelanotic macules). There is, however, considerable heterogeneity in the neurologic manifestations. It is also associated with cortical tuber and HAMARTOMAS formation throughout the body, especially the heart, kidneys, and eyes. Mutations in two loci TSC1 and TSC2 that encode hamartin and tuberin, respectively, are associated with the disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Valproic acid was prescribed most frequently as first and second treatment, followed by vigabatrin." | 1.42 | Epilepsy in children with tuberous sclerosis complex: Chance of remission and response to antiepileptic drugs. ( Bindels-de Heus, K; de Wit, MC; Moll, HA; Overwater, IE; Rietman, AB; Ten Hoopen, LW; Vergouwe, Y, 2015) |
| "Tuberous sclerosis is an autosomal dominant inherited phakomatosis." | 1.36 | [Tuberous sclerosis and intracranial aneurysms: a rare association]. ( Aissi, M; Boughammoura-Bouatay, A; Frih-Ayed, M; Jerbi-Ommezzine, S; Sfar, MH; Younes-Mhenni, S, 2010) |
| "Tuberous sclerosis is a multisystem autosomal-dominant disease characterized by hamartomatous growths in the brain, skin, kidneys, eyes, and heart, but it may affect almost any organ." | 1.35 | Unilateral eyelid angiofibroma with complete blepharoptosis as the presenting sign of tuberous sclerosis. ( Lopez, JP; Miller, P; Ossandón, D; Sánchez, L; Winter, A, 2009) |
| "The pregnancy was continued and the child is developing well during 16 months of follow-up." | 1.35 | Prenatal diagnosis of cerebral lesions in Tuberous sclerosis complex (TSC). Case report and review of the literature. ( Creemers, JW; Mullaart, RA; Reimer, A; Wortmann, SB, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Overwater, IE | 1 |
| Bindels-de Heus, K | 1 |
| Rietman, AB | 1 |
| Ten Hoopen, LW | 1 |
| Vergouwe, Y | 1 |
| Moll, HA | 1 |
| de Wit, MC | 1 |
| Lopez, JP | 1 |
| Ossandón, D | 1 |
| Miller, P | 1 |
| Sánchez, L | 1 |
| Winter, A | 1 |
| Aissi, M | 1 |
| Younes-Mhenni, S | 1 |
| Jerbi-Ommezzine, S | 1 |
| Boughammoura-Bouatay, A | 1 |
| Frih-Ayed, M | 1 |
| Sfar, MH | 1 |
| Wortmann, SB | 1 |
| Reimer, A | 1 |
| Creemers, JW | 1 |
| Mullaart, RA | 1 |
4 other studies available for valproic acid and Tuberous Sclerosis
| Article | Year |
|---|---|
Epilepsy in children with tuberous sclerosis complex: Chance of remission and response to antiepileptic drugs.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Diet, Ketogenic; Epilepsies, Partial; Epilepsy | 2015 |
Unilateral eyelid angiofibroma with complete blepharoptosis as the presenting sign of tuberous sclerosis.
Topics: Angiofibroma; Blepharoptosis; Eyelid Neoplasms; GABA Agents; Gestational Age; Humans; Infant, Newbor | 2009 |
[Tuberous sclerosis and intracranial aneurysms: a rare association].
Topics: Adult; Anticonvulsants; Aspirin; Carbamazepine; Carotid Artery Diseases; Humans; Intracranial Aneury | 2010 |
Prenatal diagnosis of cerebral lesions in Tuberous sclerosis complex (TSC). Case report and review of the literature.
Topics: Adult; Anticonvulsants; Brain; Female; Genetic Counseling; Heart Neoplasms; Humans; Infant, Newborn; | 2008 |