valproic acid has been researched along with Triple Negative Breast Neoplasms in 4 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Triple Negative Breast Neoplasms: Breast neoplasms that do not express ESTROGEN RECEPTORS; PROGESTERONE RECEPTORS; and do not overexpress the NEU RECEPTOR/HER-2 PROTO-ONCOGENE PROTEIN.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Valproic acid (VPA) is a selective histone deacetylation (HDAC) inhibitor and exerts anti-cancer properties in different types of cancer." | 1.62 | Regulation of valproic acid induced EMT by AKT/GSK3β/β-catenin signaling pathway in triple negative breast cancer. ( Deveci Ozkan, A; Guney Eskiler, G; Kaleli, S; Ozbek Iptec, B; Ozman, Z; Sahin, E, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 2 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Estrada-Pérez, AR | 1 |
| García-Vázquez, JB | 1 |
| Mendoza-Figueroa, HL | 1 |
| Rosales-Hernández, MC | 1 |
| Fernández-Pomares, C | 1 |
| Correa-Basurto, J | 1 |
| Ozman, Z | 1 |
| Ozbek Iptec, B | 1 |
| Sahin, E | 1 |
| Guney Eskiler, G | 1 |
| Deveci Ozkan, A | 1 |
| Kaleli, S | 1 |
| Wiegmans, AP | 1 |
| Yap, PY | 1 |
| Ward, A | 1 |
| Lim, YC | 1 |
| Khanna, KK | 1 |
| Sulaiman, A | 1 |
| Sulaiman, B | 1 |
| Khouri, L | 1 |
| McGarry, S | 1 |
| Nessim, C | 1 |
| Arnaout, A | 1 |
| Li, X | 1 |
| Addison, C | 1 |
| Dimitroulakos, J | 1 |
| Wang, L | 1 |
4 other studies available for valproic acid and Triple Negative Breast Neoplasms
| Article | Year |
|---|---|
Untargeted LC-MS/MS Metabolomics Study of HO-AAVPA and VPA on Breast Cancer Cell Lines.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Chromatography, Liquid; Female; Humans; MCF- | 2023 |
Regulation of valproic acid induced EMT by AKT/GSK3β/β-catenin signaling pathway in triple negative breast cancer.
Topics: Apoptosis; beta Catenin; Cadherins; Cell Line, Tumor; Epithelial-Mesenchymal Transition; Female; Gen | 2021 |
Differences in Expression of Key DNA Damage Repair Genes after Epigenetic-Induced BRCAness Dictate Synthetic Lethality with PARP1 Inhibition.
Topics: Antineoplastic Agents; Benzimidazoles; BRCA1 Protein; Cell Line, Tumor; Cell Survival; Depsipeptides | 2015 |
Both bulk and cancer stem cell subpopulations in triple-negative breast cancer are susceptible to Wnt, HDAC, and ERα coinhibition.
Topics: Antineoplastic Agents; beta Catenin; CD24 Antigen; Cell Line; Cell Proliferation; Epithelial Cells; | 2016 |