valproic acid has been researched along with Trigeminal Neuralgia in 9 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Trigeminal Neuralgia: A syndrome characterized by recurrent episodes of excruciating pain lasting several seconds or longer in the sensory distribution of the TRIGEMINAL NERVE. Pain may be initiated by stimulation of trigger points on the face, lips, or gums or by movement of facial muscles or chewing. Associated conditions include MULTIPLE SCLEROSIS, vascular anomalies, ANEURYSMS, and neoplasms. (Adams et al., Principles of Neurology, 6th ed, p187)
| Excerpt | Relevance | Reference |
|---|---|---|
| " For treating trigeminal neuralgia, carbamazepine had a combined number needed to treat of 2." | 6.17 | Anticonvulsant drugs for management of pain: a systematic review. ( Carroll, D; Jadad, AR; McQuay, H; Moore, A; Wiffen, P, 1995) |
| " In our article, we report two sisters, one of whom was treated with levothyroxine because of hypothyroidism." | 3.80 | Transient hypothyroidism induced by anticonvulsant agents. ( Krysiak, R; Stojko, R, 2014) |
| "The present study showed that the administration of multidrug regimens is a useful alternative in controlling trigeminal neuralgia in patients who are unable to tolerate higher doses of carbamazepine." | 3.78 | Use of single- and multi-drug regimens in the management of classic (idiopathic) trigeminal neuralgia: an 11-year experience at a single Sri Lankan institution. ( Ariyawardana, A; Pallegama, R; Ranasinghe, A; Sitheeque, M, 2012) |
| " On the basis of these considerations and clinical reports describing the use of these drugs, we make dosage recommendations to enable the practitioner to individualize therapeutic regimens." | 2.38 | Drugs used in the management of trigeminal neuralgia. ( Patsalos, PN; Zakrzewska, JM, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (44.44) | 18.7374 |
| 1990's | 2 (22.22) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Krysiak, R | 1 |
| Stojko, R | 1 |
| Piovesan, EJ | 1 |
| Randunz, V | 1 |
| Utiumi, M | 1 |
| Lange, MC | 1 |
| Kowacs, PA | 1 |
| Mulinari, RA | 1 |
| Oshinsky, M | 1 |
| Vital, M | 1 |
| Sereniki, A | 1 |
| Fernandes, AF | 1 |
| e Silva, LL | 1 |
| Werneck, LC | 1 |
| Ariyawardana, A | 1 |
| Pallegama, R | 1 |
| Sitheeque, M | 1 |
| Ranasinghe, A | 1 |
| Karlov, VA | 1 |
| Savitskaia, ON | 1 |
| Peiris, JB | 1 |
| Perera, GL | 1 |
| Devendra, SV | 1 |
| Lionel, ND | 1 |
| McQuay, H | 1 |
| Carroll, D | 1 |
| Jadad, AR | 1 |
| Wiffen, P | 1 |
| Moore, A | 1 |
| Zakrzewska, JM | 1 |
| Patsalos, PN | 1 |
| Gram, L | 1 |
| Bentsen, KD | 1 |
| Grosshandler, S | 1 |
| Gray, W | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Erenumab as a Therapeutic Approach for the Management of Trigeminal Neuropathic Pain (TNP)[NCT05142228] | Phase 2 | 5 participants (Actual) | Interventional | 2022-04-01 | Terminated (stopped due to Low enrollment rate) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for valproic acid and Trigeminal Neuralgia
| Article | Year |
|---|---|
Anticonvulsant drugs for management of pain: a systematic review.
Topics: Anticonvulsants; Carbamazepine; Clonazepam; Diabetic Neuropathies; Humans; Pain; Phenytoin; Treatmen | 1995 |
Drugs used in the management of trigeminal neuralgia.
Topics: Anticonvulsants; Baclofen; Carbamazepine; Clonazepam; Humans; Oxcarbazepine; Phenytoin; Trigeminal N | 1992 |
Valproate: an updated review.
Topics: Abnormalities, Drug-Induced; Brain Diseases; Chemical and Drug Induced Liver Injury; Coma; Dyskinesi | 1985 |
1 trial available for valproic acid and Trigeminal Neuralgia
| Article | Year |
|---|---|
Anticonvulsant drugs for management of pain: a systematic review.
Topics: Anticonvulsants; Carbamazepine; Clonazepam; Diabetic Neuropathies; Humans; Pain; Phenytoin; Treatmen | 1995 |
6 other studies available for valproic acid and Trigeminal Neuralgia
| Article | Year |
|---|---|
Transient hypothyroidism induced by anticonvulsant agents.
Topics: Adult; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Female; Gabapentin; gamm | 2014 |
Influence of NMDA and non-NMDA antagonists on acute and inflammatory pain in the trigeminal territory: a placebo control study.
Topics: Animals; Exploratory Behavior; Facial Pain; Fructose; Inflammation; Male; Memantine; Motor Activity; | 2008 |
Use of single- and multi-drug regimens in the management of classic (idiopathic) trigeminal neuralgia: an 11-year experience at a single Sri Lankan institution.
Topics: Adult; Aged; Aged, 80 and over; Amines; Amitriptyline; Analgesics; Carbamazepine; Cyclohexanecarboxy | 2012 |
[Comparative effectiveness of antiepileptic preparations in the treatment of patients with trigeminal neuralgia].
Topics: Anticonvulsants; Carbamazepine; Clonazepam; Ethosuximide; Follow-Up Studies; Humans; Morpholines; Py | 1980 |
Sodium valproate in trigeminal neuralgia.
Topics: Aged; Anticonvulsants; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Trigeminal Neur | 1980 |
Successful therapy of postherpetic neuralgia of the trigeminal nerve.
Topics: Combined Modality Therapy; Diflunisal; Doxepin; Female; Herpes Zoster; Humans; Middle Aged; Physical | 1985 |