valproic acid has been researched along with Thyroid Carcinoma, Anaplastic in 4 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Thyroid Carcinoma, Anaplastic: An aggressive THYROID GLAND malignancy which generally occurs in IODINE-deficient areas in people with previous thyroid pathology such as GOITER. It is associated with CELL DEDIFFERENTIATION of THYROID CARCINOMA (e.g., FOLLICULAR THYROID CARCINOMA; PAPILLARY THYROID CANCER). Typical initial presentation is a rapidly growing neck mass which upon metastasis is associated with DYSPHAGIA; NECK PAIN; bone pain; DYSPNEA; and NEUROLOGIC DEFICITS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Valproic acid (VA) is a clinically available histone deacetylase inhibitor with a well-documented side effect profile." | 1.91 | Valproic acid radiosensitizes anaplastic thyroid cells through a decrease of the DNA damage repair capacity. ( Campos-Haedo, M; Cremaschi, G; Dagrosa, MA; Durán, HA; Grissi, C; Ibañez, IL; Juvenal, GJ; Oglio, R; Perona, M; Rosemblit, C; Thomasz, L; Villaverde, MS, 2023) |
| "Anaplastic thyroid cancer is an aggressive and highly lethal cancer for which conventional therapies have proved ineffective." | 1.43 | Generation of Novel Thyroid Cancer Stem-Like Cell Clones: Effects of Resveratrol and Valproic Acid. ( Chen, H; Chen, J; Hardin, H; Harrison, AD; Larrain, C; Lloyd, RV; Yu, XM; Zhang, R, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 2 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Perona, M | 1 |
| Ibañez, IL | 1 |
| Thomasz, L | 1 |
| Villaverde, MS | 1 |
| Oglio, R | 1 |
| Rosemblit, C | 1 |
| Grissi, C | 1 |
| Campos-Haedo, M | 1 |
| Dagrosa, MA | 1 |
| Cremaschi, G | 1 |
| Durán, HA | 1 |
| Juvenal, GJ | 1 |
| Gunel, NS | 1 |
| Birden, N | 1 |
| Kurt, CC | 1 |
| Bagca, BG | 1 |
| Shademan, B | 1 |
| Sogutlu, F | 1 |
| Ozates, NP | 1 |
| Avci, CB | 1 |
| Cha, HY | 1 |
| Lee, BS | 1 |
| Kang, S | 1 |
| Shin, YS | 1 |
| Chang, JW | 1 |
| Sung, ES | 1 |
| Kim, YS | 1 |
| Choi, JW | 1 |
| Kim, JH | 1 |
| Kim, CH | 1 |
| Hardin, H | 1 |
| Yu, XM | 1 |
| Harrison, AD | 1 |
| Larrain, C | 1 |
| Zhang, R | 1 |
| Chen, J | 1 |
| Chen, H | 1 |
| Lloyd, RV | 1 |
4 other studies available for valproic acid and Thyroid Carcinoma, Anaplastic
| Article | Year |
|---|---|
Valproic acid radiosensitizes anaplastic thyroid cells through a decrease of the DNA damage repair capacity.
Topics: Cell Line, Tumor; DNA Damage; Histones; Humans; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; Va | 2023 |
Effect of valproic acid on miRNAs affecting histone deacetylase in a model of anaplastic thyroid cancer.
Topics: Biomarkers, Tumor; Cell Line, Tumor; Gene Expression; Gene Expression Profiling; Gene Expression Reg | 2021 |
Valproic acid sensitizes TRAIL-resistant anaplastic thyroid carcinoma cells to apoptotic cell death.
Topics: Anticonvulsants; Apoptosis; Biomarkers, Tumor; Blotting, Western; Cell Proliferation; Drug Resistanc | 2013 |
Generation of Novel Thyroid Cancer Stem-Like Cell Clones: Effects of Resveratrol and Valproic Acid.
Topics: Animals; Antioxidants; Blotting, Western; Cell Culture Techniques; Cell Line, Tumor; Enzyme Inhibito | 2016 |