valproic acid has been researched along with Thrombotic Microangiopathies in 1 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Thrombotic Microangiopathies: Diseases that result in THROMBOSIS in MICROVASCULATURE. The two most prominent diseases are PURPURA, THROMBOTIC THROMBOCYTOPENIC; and HEMOLYTIC-UREMIC SYNDROME. Multiple etiological factors include VASCULAR ENDOTHELIAL CELL damage due to SHIGA TOXIN; FACTOR H deficiency; and aberrant VON WILLEBRAND FACTOR formation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "An adolescent male with difficult to control epilepsy was admitted for impaired hepatic function while on valproic acid therapy." | 3.85 | Thrombotic microangiopathy associated with Valproic acid toxicity. ( Bohan, TP; Erikson, CL; Hebert, SA; Swinford, RD, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hebert, SA | 1 |
| Bohan, TP | 1 |
| Erikson, CL | 1 |
| Swinford, RD | 1 |
1 other study available for valproic acid and Thrombotic Microangiopathies
| Article | Year |
|---|---|
Thrombotic microangiopathy associated with Valproic acid toxicity.
Topics: Adolescent; Anticonvulsants; Epilepsy; Humans; Male; Thrombotic Microangiopathies; Valproic Acid | 2017 |