valproic acid has been researched along with Thrombopenia in 83 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thirteen children with intractable epilepsy were treated by means of three-times-daily administration of a conventional preparation of valproic acid (C-VPA) and twice-daily administration of a new slow-release preparation of VPA (SR-VPA) with the cross-over technique." | 9.07 | A comparative clinical and pharmacokinetic study of a new slow-release versus conventional preparations of valproic acid in children with intractable epilepsy. ( Fukuyama, Y; Imaizumi, T; Izumi, T, 1992) |
| "In January 2019, a new plant-derived purified cannabidiol preparation, approved by the US Food and Drug Administration, became commercially available for patients ≥2 years old with Lennox-Gastaut syndrome or Dravet syndrome." | 7.96 | Thrombocytopenia in pediatric patients on concurrent cannabidiol and valproic acid. ( Carlson, M; Dang, LT; Fedak Romanowski, EM; Joshi, SM; Leber, SM; McNamara, NA; Robertson, P; Shellhaas, RA; Smith, GC; Sturza, J; Ziobro, JM, 2020) |
| "BACKGROUND Valproic acid is utilized for the management of various disease states, but coagulation changes, such as thrombocytopenia, can limit use." | 7.96 | Valproic Acid-Induced Thrombocytopenia-Related Spontaneous Systemic Bleeding. ( Johnston, JP; Nerenberg, SF, 2020) |
| "To evaluate whether valproic acid (VPA) can cause thrombocytopenia and impaired platelet function in young patients with new-onset bipolar disorder." | 7.72 | Thrombocytopenia during valproic acid treatment in young patients with new-onset bipolar disorder. ( Campanella, D; De Berardis, D; Ferro, FM; Gambi, F; Grimaldi, MR; La Rovere, R; Matera, V; Pacilli, AM; Salerno, RM; Sepede, G, 2003) |
| "To describe a case of oral valproic acid-induced hyperammonemia and thrombocytopenia in an elderly patient." | 7.72 | Valproic acid-induced hyperammonemia and thrombocytopenia in an elderly woman. ( Babin, S; Mallet, L; Morais, JA, 2004) |
| "To investigate the prevalence and potential risk factors of thrombocytopenia in hospitalized patients receiving valproic acid (VPA) for psychiatric indications (excluding epilepsy)." | 7.71 | Prevalence and risk of thrombocytopenia with valproic acid: experience at a psychiatric teaching hospital. ( Branch, RA; Coley, KC; Conley, EL; Dapos, SV; Maxwell, R; Pollock, BG, 2001) |
| "It is not known whether polytherapy with carbamazepine (CBZ) and valproate (VPA) increases the risk of thrombocytopenia." | 7.71 | Severe, isolated thrombocytopenia under polytherapy with carbamazepine and valproate. ( Finsterer, J; Hess, B; Pelzl, G, 2001) |
| "To investigate the relationship between platelet count and serum valproic acid level, age, duration of valproic acid therapy, and polytherapy, and to determine the clinical significance of thrombocytopenia associated with high-dosage valproic acid therapy." | 7.71 | Valproic acid and thrombocytopenia: cross-sectional study. ( Ko, CH; Kong, CK; Tse, PW, 2001) |
| " The authors present a bipolar disorder patient with dose-dependent valproic acid thrombocytopenia and suggest treatment strategies." | 7.70 | Dose-dependent valproic acid thrombocytopenia in bipolar disorder. ( Gerner, R; Kaufman, KR, 1998) |
| "Thrombocytopenia in association with valproic acid (VPA) therapy has been reported in patients of various ages with incidences ranging from 1 to 32%." | 7.69 | Valproic acid and thrombocytopenia in children: a case-controlled retrospective study. ( Allarakhia, IN; Garofalo, EA; Komarynski, MA; Robertson, PL, 1996) |
| "During the course of a prospective serial study over a period of one year, findings compatible with immune-mediated thrombocytolysis accompanied the administration of valproic acid in about half of 45 children with epilepsy." | 7.66 | Valproic acid and immune thrombocytopenia. ( Barr, RD; Copeland, SA; Kelton, JC; Morris, N; Stockwell, ML, 1982) |
| "Valproic acid (VPA) is an effective first-line anticonvulsant that is associated with several side effects including bone marrow suppression and subsequent cytopenia." | 5.72 | Valproic Acid Induced Thrombocytopenia and Dysmegakaryopoiesis in a Pediatric Patient. ( Akgun, Y; Baykara, Y; Langlie, J; Poveda, J; Van Truong, L, 2022) |
| "Thrombocytopenia is common in NCU patients." | 5.56 | Thrombocytopenia during intravenous valproic acid therapy in the neurological intensive care unit. ( Chun, YI; Kim, DW; Kim, W; Lee, CH, 2020) |
| "Thirteen children with intractable epilepsy were treated by means of three-times-daily administration of a conventional preparation of valproic acid (C-VPA) and twice-daily administration of a new slow-release preparation of VPA (SR-VPA) with the cross-over technique." | 5.07 | A comparative clinical and pharmacokinetic study of a new slow-release versus conventional preparations of valproic acid in children with intractable epilepsy. ( Fukuyama, Y; Imaizumi, T; Izumi, T, 1992) |
| " We report the case of a young man with a first episode schizophrenia who experienced thrombocytopenic purpura following the administration of quetiapine co-prescribed with valproic acid." | 4.31 | Quetiapine-associated thrombocytopenic purpura in a young man with a first episode schizophrenia. ( Cheour, M; Cherif, W; Fekih-Romdhane, F; Jenhani, R, 2023) |
| "In January 2019, a new plant-derived purified cannabidiol preparation, approved by the US Food and Drug Administration, became commercially available for patients ≥2 years old with Lennox-Gastaut syndrome or Dravet syndrome." | 3.96 | Thrombocytopenia in pediatric patients on concurrent cannabidiol and valproic acid. ( Carlson, M; Dang, LT; Fedak Romanowski, EM; Joshi, SM; Leber, SM; McNamara, NA; Robertson, P; Shellhaas, RA; Smith, GC; Sturza, J; Ziobro, JM, 2020) |
| "BACKGROUND Valproic acid is utilized for the management of various disease states, but coagulation changes, such as thrombocytopenia, can limit use." | 3.96 | Valproic Acid-Induced Thrombocytopenia-Related Spontaneous Systemic Bleeding. ( Johnston, JP; Nerenberg, SF, 2020) |
| "To describe a case of oral valproic acid-induced hyperammonemia and thrombocytopenia in an elderly patient." | 3.72 | Valproic acid-induced hyperammonemia and thrombocytopenia in an elderly woman. ( Babin, S; Mallet, L; Morais, JA, 2004) |
| "To evaluate whether valproic acid (VPA) can cause thrombocytopenia and impaired platelet function in young patients with new-onset bipolar disorder." | 3.72 | Thrombocytopenia during valproic acid treatment in young patients with new-onset bipolar disorder. ( Campanella, D; De Berardis, D; Ferro, FM; Gambi, F; Grimaldi, MR; La Rovere, R; Matera, V; Pacilli, AM; Salerno, RM; Sepede, G, 2003) |
| "We report the case of a 4-year-old boy with long-term sodium valproate (valproic acid; VPA) therapy who suddenly developed clinically relevant thrombocytopenia and signs of hepatotoxicity." | 3.72 | Valproic-acid-induced thrombocytopenia and hepatotoxicity: discontinuation of treatment? ( Lackmann, GM, 2004) |
| "It is not known whether polytherapy with carbamazepine (CBZ) and valproate (VPA) increases the risk of thrombocytopenia." | 3.71 | Severe, isolated thrombocytopenia under polytherapy with carbamazepine and valproate. ( Finsterer, J; Hess, B; Pelzl, G, 2001) |
| "To investigate the prevalence and potential risk factors of thrombocytopenia in hospitalized patients receiving valproic acid (VPA) for psychiatric indications (excluding epilepsy)." | 3.71 | Prevalence and risk of thrombocytopenia with valproic acid: experience at a psychiatric teaching hospital. ( Branch, RA; Coley, KC; Conley, EL; Dapos, SV; Maxwell, R; Pollock, BG, 2001) |
| "We present three children with severe therapy-refractory epilepsy who tolerated valproate (VPA) well in various combinations with other antiepileptic drugs (AEDs) but developed typical VPA side effects in combination with topiramate (TPM)." | 3.71 | Topiramate enhances the risk of valproate-associated side effects in three children. ( Koelfen, W; König, S; Longin, E; Teich, M, 2002) |
| " Patients with high-grade gliomas were treated with up-front chemotherapy regimen consisting of fotemustine (d3: 100 mg/m2), cisplatin (d1-3: 33 mg/m2) and etoposide (d1-3: 75 mg/m2) followed by whole brain radiotherapy at progression." | 3.71 | Nitroso-urea-cisplatin-based chemotherapy associated with valproate: increase of haematologic toxicity. ( Bourg, V; Chichmanian, RM; Frenay, M; Lebrun, C; Thomas, P, 2001) |
| "To investigate the relationship between platelet count and serum valproic acid level, age, duration of valproic acid therapy, and polytherapy, and to determine the clinical significance of thrombocytopenia associated with high-dosage valproic acid therapy." | 3.71 | Valproic acid and thrombocytopenia: cross-sectional study. ( Ko, CH; Kong, CK; Tse, PW, 2001) |
| " The authors present a bipolar disorder patient with dose-dependent valproic acid thrombocytopenia and suggest treatment strategies." | 3.70 | Dose-dependent valproic acid thrombocytopenia in bipolar disorder. ( Gerner, R; Kaufman, KR, 1998) |
| "The purpose of this study was to determine the occurrence of leukopenia and other blood dyscrasias associated with psychiatric use of carbamazepine and valproate." | 3.69 | Blood dyscrasias with carbamazepine and valproate: a pharmacoepidemiological study of 2,228 patients at risk. ( Baldessarini, RJ; Castillo, J; Kando, JC; Tohen, M; Zarate, C, 1995) |
| "Thrombocytopenia in association with valproic acid (VPA) therapy has been reported in patients of various ages with incidences ranging from 1 to 32%." | 3.69 | Valproic acid and thrombocytopenia in children: a case-controlled retrospective study. ( Allarakhia, IN; Garofalo, EA; Komarynski, MA; Robertson, PL, 1996) |
| "During the course of a prospective serial study over a period of one year, findings compatible with immune-mediated thrombocytolysis accompanied the administration of valproic acid in about half of 45 children with epilepsy." | 3.66 | Valproic acid and immune thrombocytopenia. ( Barr, RD; Copeland, SA; Kelton, JC; Morris, N; Stockwell, ML, 1982) |
| "The side effects and possible side effects of the therapy with valproic acid were documented in 66 outpatients with epilepsy over a period of one year." | 3.66 | [Antiepileptic therapy with valproinic acid. Correlations of side effects and serum levels of valproinic acid]. ( Fröscher, W; Gugler, R; Schulz, HU, 1979) |
| "Patients with refractory partial epilepsy were enrolled in this double-blind, multicenter, concentration-response trial that evaluated the efficacy and safety of high versus low trough plasma VPA concentrations following administration of divalproex sodium as monotherapy." | 2.73 | Valproate-induced thrombocytopenia: a prospective monotherapy study. ( Beydoun, A; Nasreddine, W, 2008) |
| "Fibrinogen was significantly reduced." | 2.73 | High incidence of vaproate-induced coagulation disorders in children receiving valproic acid: a prospective study. ( Dempfle, CE; Gerstner, T; Keller, A; Koenig, S; Longin, E; Teich, M, 2008) |
| "Although survival rates for acute lymphocytic leukemia (ALL), especially in children, have shown dramatic improvement over time, poor outcomes are still observed in patients who have refractory or relapsed disease after conventional chemotherapy." | 2.49 | Recent advancements of bortezomib in acute lymphocytic leukemia treatment. ( Chen, Q; Du, XL, 2013) |
| "A diagnosis of neuroleptic malignant syndrome was made and the patient continued to receive aggressive supportive care." | 2.41 | Neuroleptic malignant syndrome and severe thrombocytopenia: case report and literature review. ( Ahmed, W; Ghani, SO; Marco, LA, 2000) |
| "Rare, serious adverse effects of antiepileptic drugs (AEDs) include hepatotoxicity and bone marrow suppression." | 2.38 | Routine laboratory monitoring for serious adverse effects of antiepileptic medications: the controversy. ( Wyllie, E; Wyllie, R, 1991) |
| "Valproic acid (VPA) is an effective first-line anticonvulsant that is associated with several side effects including bone marrow suppression and subsequent cytopenia." | 1.72 | Valproic Acid Induced Thrombocytopenia and Dysmegakaryopoiesis in a Pediatric Patient. ( Akgun, Y; Baykara, Y; Langlie, J; Poveda, J; Van Truong, L, 2022) |
| "Valproic acid (VPA) is a frequently prescribed anti-epileptic drug." | 1.72 | Assessment of need for hemostatic evaluation in patients taking valproic acid: A retrospective cross-sectional study. ( Beckers, EAM; Henskens, YMC; Heubel-Moenen, FCJI; Klinkenberg, S; Post, DS; Rijkers, K; Schijns, OEMG; van der Veer, A; van Kranen-Mastenbroek, VHJM; Verhezen, PWM; Wagner, GL; Willems, PCPH, 2022) |
| "Thrombocytopenia is common in NCU patients." | 1.56 | Thrombocytopenia during intravenous valproic acid therapy in the neurological intensive care unit. ( Chun, YI; Kim, DW; Kim, W; Lee, CH, 2020) |
| "The valproic acid plasma level was very high (1437 μg/mL), confirming it was a severe intoxication." | 1.37 | [Acute valproic acid intoxication: interest of a treatment by extracoporeal elimination combined with L-carnitine]. ( Alluin, A; Canevet, C; Desmaretz, JL; Gauthier, N; Jezequel, J, 2011) |
| "Valproic acid (VPA) is an antiepileptic drug (AED) commonly used for generalized and focal epilepsies." | 1.33 | Valproate-associated coagulopathies are frequent and variable in children. ( Bell, N; Brand, J; Dempfle, CE; Gerstner, T; König, S; Longin, E; Teich, M, 2006) |
| " Toxic damage of CNS was the most significant." | 1.30 | [Side effects of anticonvulsants in the treatment of idiopathic generalized epilepsy]. ( Mukhin, KIu; Petrukhin, AS; Rykova, EA, 1997) |
| "He had been treated with valproate for seizures since the age of 2 years." | 1.29 | Haematological disturbances during long-term valproate therapy. ( Brichard, B; Cornu, G; Ninane, J; Scheiff, JM; Vermylen, C, 1994) |
| " These side-effects are dose-related, and the daily dosage should never exceed 40 mg/kg." | 1.26 | [Sodium valproate, platelet dysfunction and bleeding (author's transl)]. ( Loiseau, P, 1981) |
| "Thrombocytopenia has been occasionally reported in patients on sodium valproate." | 1.26 | Sodium valproate and thrombocytopenia. ( Honda, K; Ike, Y; Kimura, S; Miyake, S, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (28.92) | 18.7374 |
| 1990's | 12 (14.46) | 18.2507 |
| 2000's | 22 (26.51) | 29.6817 |
| 2010's | 14 (16.87) | 24.3611 |
| 2020's | 11 (13.25) | 2.80 |
| Authors | Studies |
|---|---|
| Schoonjans, A | 1 |
| Maes, P | 1 |
| Ceulemans, B | 1 |
| Nasreddine, W | 2 |
| Atweh, SF | 1 |
| Beydoun, AA | 1 |
| Dirani, M | 1 |
| Nawfal, O | 1 |
| Beydoun, A | 2 |
| Post, DS | 1 |
| van der Veer, A | 1 |
| Schijns, OEMG | 1 |
| Klinkenberg, S | 1 |
| Rijkers, K | 1 |
| Wagner, GL | 1 |
| van Kranen-Mastenbroek, VHJM | 1 |
| Willems, PCPH | 1 |
| Verhezen, PWM | 1 |
| Beckers, EAM | 1 |
| Heubel-Moenen, FCJI | 1 |
| Henskens, YMC | 1 |
| Fekih-Romdhane, F | 1 |
| Jenhani, R | 1 |
| Cherif, W | 1 |
| Cheour, M | 1 |
| Young, MR | 1 |
| Bisaccia, EK | 1 |
| Romantseva, L | 1 |
| Hovey, SW | 1 |
| Akgun, Y | 1 |
| Baykara, Y | 1 |
| Langlie, J | 1 |
| Van Truong, L | 1 |
| Poveda, J | 1 |
| Tien, Y | 1 |
| Gandhi, M | 1 |
| Rac, MWF | 1 |
| McKinney, J | 1 |
| Park, A | 1 |
| Shapiro, B | 1 |
| Hedayati, B | 1 |
| Faziola, L | 1 |
| Alsallumi, MS | 1 |
| Kim, DW | 1 |
| Kim, W | 1 |
| Lee, CH | 1 |
| Chun, YI | 1 |
| McNamara, NA | 1 |
| Dang, LT | 1 |
| Sturza, J | 1 |
| Ziobro, JM | 1 |
| Fedak Romanowski, EM | 1 |
| Smith, GC | 1 |
| Joshi, SM | 1 |
| Leber, SM | 1 |
| Carlson, M | 1 |
| Robertson, P | 1 |
| Shellhaas, RA | 1 |
| Stuver, R | 1 |
| Khanna, P | 1 |
| Wischhusen, JW | 1 |
| Cobb, C | 1 |
| Bockorny, B | 1 |
| Johnston, JP | 1 |
| Nerenberg, SF | 1 |
| Kurahashi, H | 1 |
| Takami, A | 1 |
| Murotani, K | 1 |
| Numoto, S | 1 |
| Okumura, A | 1 |
| Buoli, M | 1 |
| Serati, M | 1 |
| Botturi, A | 1 |
| Altamura, AC | 1 |
| Yaman, A | 1 |
| Kendirli, T | 1 |
| Odek, C | 1 |
| Bektaş, O | 1 |
| Kuloğlu, Z | 1 |
| Koloğlu, M | 1 |
| Ince, E | 1 |
| Deda, G | 1 |
| Weiner, D | 1 |
| Nir, V | 1 |
| Klein-Kremer, A | 1 |
| Kassem, E | 1 |
| Abdallah, C | 1 |
| Greinacher, A | 1 |
| Selleng, S | 1 |
| Koenig, S | 1 |
| Gerstner, T | 2 |
| Keller, A | 1 |
| Teich, M | 3 |
| Longin, E | 3 |
| Dempfle, CE | 2 |
| Vasudev, K | 1 |
| Keown, P | 1 |
| Gibb, I | 1 |
| McAllister-Williams, RH | 1 |
| Alluin, A | 1 |
| Jezequel, J | 1 |
| Gauthier, N | 1 |
| Desmaretz, JL | 1 |
| Canevet, C | 1 |
| Lin, YH | 1 |
| Chien, YL | 1 |
| Gekht, AB | 1 |
| Du, XL | 1 |
| Chen, Q | 1 |
| Gesundheit, B | 1 |
| Kirby, M | 1 |
| Lau, W | 1 |
| Koren, G | 1 |
| Abdelhaleem, M | 1 |
| Yoshikawa, H | 1 |
| De Berardis, D | 1 |
| Campanella, D | 1 |
| Matera, V | 1 |
| Gambi, F | 1 |
| La Rovere, R | 1 |
| Sepede, G | 1 |
| Grimaldi, MR | 1 |
| Pacilli, AM | 1 |
| Salerno, RM | 1 |
| Ferro, FM | 1 |
| Kielstein, JT | 1 |
| Woywodt, A | 1 |
| Schumann, G | 1 |
| Haller, H | 1 |
| Fliser, D | 1 |
| Lackmann, GM | 1 |
| Mallet, L | 1 |
| Babin, S | 1 |
| Morais, JA | 1 |
| Morozov, GV | 1 |
| Semenova, NV | 1 |
| Slastenko, OA | 1 |
| Mishchenko, AL | 1 |
| Tsivkin, R | 1 |
| Saito, E | 1 |
| Kafantaris, V | 1 |
| Bell, N | 1 |
| Brand, J | 1 |
| König, S | 2 |
| Attilakos, A | 1 |
| Katsarou, E | 1 |
| Voudris, K | 1 |
| Garoufi, A | 1 |
| Eastham, RD | 1 |
| Jancar, J | 1 |
| Smith, FR | 1 |
| Boots, M | 1 |
| Morris, N | 2 |
| Barr, RD | 3 |
| Pai, KR | 1 |
| Kelton, JG | 2 |
| Diehl, LW | 1 |
| Loiseau, P | 1 |
| Hoffman, LM | 1 |
| Loisseau, P | 1 |
| Martínez-Lage, JM | 1 |
| Hackett, T | 1 |
| Powers, P | 1 |
| Patel, CC | 1 |
| Church, S | 1 |
| Reilly, KM | 1 |
| Copeland, SA | 1 |
| Stockwell, ML | 1 |
| Kelton, JC | 1 |
| Andrew, M | 1 |
| Tohen, M | 1 |
| Castillo, J | 1 |
| Baldessarini, RJ | 1 |
| Zarate, C | 1 |
| Kando, JC | 1 |
| Delgado, MR | 1 |
| Riela, AR | 1 |
| Mills, J | 1 |
| Browne, R | 1 |
| Roach, ES | 1 |
| Brichard, B | 1 |
| Vermylen, C | 1 |
| Scheiff, JM | 1 |
| Ninane, J | 1 |
| Cornu, G | 1 |
| Ney, GC | 1 |
| Schaul, N | 1 |
| Loughlin, J | 1 |
| Rai, K | 1 |
| Chandra, V | 1 |
| Ozkara, C | 1 |
| Dreifuss, FE | 1 |
| Apperson Hansen, C | 1 |
| Pedersen-Bjergaard, U | 1 |
| Andersen, M | 1 |
| Hansen, PB | 1 |
| Allarakhia, IN | 1 |
| Garofalo, EA | 1 |
| Komarynski, MA | 1 |
| Robertson, PL | 1 |
| Fawcett, RG | 1 |
| Mukhin, KIu | 1 |
| Petrukhin, AS | 1 |
| Rykova, EA | 1 |
| Kaufman, KR | 1 |
| Gerner, R | 1 |
| Sleiman, C | 1 |
| Raffy, O | 1 |
| Roué, C | 1 |
| Mal, H | 1 |
| Ghani, SO | 1 |
| Ahmed, W | 1 |
| Marco, LA | 1 |
| Levine, J | 1 |
| Chengappa, KN | 1 |
| Parepally, H | 1 |
| Trannel, TJ | 1 |
| Ahmed, I | 1 |
| Goebert, D | 1 |
| Bourg, V | 1 |
| Lebrun, C | 1 |
| Chichmanian, RM | 1 |
| Thomas, P | 1 |
| Frenay, M | 1 |
| Bruel, H | 1 |
| Chabrolle, JP | 1 |
| Amusini, P | 1 |
| Levesque, L | 1 |
| Iskandar, K | 1 |
| Poinsot, J | 1 |
| Ko, CH | 1 |
| Kong, CK | 1 |
| Tse, PW | 1 |
| Finsterer, J | 1 |
| Pelzl, G | 1 |
| Hess, B | 1 |
| Conley, EL | 1 |
| Coley, KC | 1 |
| Pollock, BG | 1 |
| Dapos, SV | 1 |
| Maxwell, R | 1 |
| Branch, RA | 1 |
| Koelfen, W | 1 |
| Raworth, RE | 1 |
| Birchall, G | 1 |
| Miyake, S | 1 |
| Honda, K | 1 |
| Kimura, S | 1 |
| Ike, Y | 1 |
| Fröscher, W | 1 |
| Schulz, HU | 1 |
| Gugler, R | 1 |
| Krause, KH | 1 |
| Cole, AP | 1 |
| Sandler, RM | 1 |
| Emberson, C | 1 |
| Roberts, GE | 1 |
| Voak, D | 1 |
| Darnborough, J | 1 |
| Heeley, AF | 1 |
| Neophytides, AN | 1 |
| Nutt, JG | 1 |
| Lodish, JR | 1 |
| Monnet, P | 1 |
| David, M | 1 |
| Philippe, N | 1 |
| Dechavanne, M | 1 |
| Floret, D | 1 |
| Renaud, H | 1 |
| Trezeciak, MC | 1 |
| Brazier, JL | 1 |
| Bourdillon, D | 1 |
| Sutor, AH | 1 |
| Jesdinsky-Buscher, C | 1 |
| Winfield, DA | 1 |
| Benton, P | 1 |
| Espir, ML | 1 |
| Arthur, LJ | 1 |
| Stolzis, L | 1 |
| Scheffner, D | 1 |
| Imaizumi, T | 1 |
| Izumi, T | 1 |
| Fukuyama, Y | 1 |
| Wyllie, E | 1 |
| Wyllie, R | 1 |
| Terui, T | 1 |
| Ktda, K | 1 |
| Mitani, T | 1 |
| Terada, S | 1 |
| Kure, T | 1 |
| Takamura, H | 1 |
| Hirayama, M | 1 |
| Niitsu, Y | 1 |
| Nakazawa, O | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Combined Scalp and Ear Acupuncture in Patients With Proton Pump Inhibitor- Dependent Gastroesophageal Reflux Disease[NCT04660019] | 43 participants (Actual) | Interventional | 2020-08-10 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for valproic acid and Thrombopenia
| Article | Year |
|---|---|
The Risk of Thrombocytopenia During Valproic Acid Therapy: A Critical Summary of Available Clinical Data.
Topics: Anticonvulsants; Humans; Risk Factors; Thrombocytopenia; Valproic Acid | 2018 |
Valproic acid-induced acute pancreatitis and multiorgan failure in a child.
Topics: Abdominal Pain; Acute Disease; Anticonvulsants; Child; Delayed Diagnosis; Diagnostic Errors; Dissemi | 2013 |
Recent advancements of bortezomib in acute lymphocytic leukemia treatment.
Topics: Antineoplastic Agents; Boronic Acids; Bortezomib; Drug Therapy, Combination; Fusion Proteins, bcr-ab | 2013 |
Drug-induced platelet destruction.
Topics: Binding Sites, Antibody; Blood Platelets; Cell Differentiation; Cell Migration Inhibition; Clot Retr | 1982 |
Increased platelet destruction in infancy and childhood.
Topics: Adrenal Cortex Hormones; Anemia, Hemolytic; Animals; Autoimmune Diseases; Blood Platelets; Child; Ch | 1982 |
Neuroleptic malignant syndrome and severe thrombocytopenia: case report and literature review.
Topics: Adult; Antipsychotic Agents; Drug Therapy, Combination; Haloperidol; Humans; Male; Neuroleptic Malig | 2000 |
Routine laboratory monitoring for serious adverse effects of antiepileptic medications: the controversy.
Topics: Anemia, Aplastic; Anticonvulsants; Carbamazepine; Chemical and Drug Induced Liver Injury; Drug Monit | 1991 |
4 trials available for valproic acid and Thrombopenia
| Article | Year |
|---|---|
High incidence of vaproate-induced coagulation disorders in children receiving valproic acid: a prospective study.
Topics: Anticonvulsants; Blood Platelets; Child; Child, Preschool; Factor XIII; Female; Fibrinogen; Humans; | 2008 |
Valproate-induced thrombocytopenia: a prospective monotherapy study.
Topics: Adolescent; Adult; Age Distribution; Anticonvulsants; Child; Double-Blind Method; Epilepsies, Partia | 2008 |
Thrombocytopenia secondary to high valproate levels in children with epilepsy.
Topics: Carbamazepine; Child; Dose-Response Relationship, Drug; Epilepsy; Female; Humans; Male; Platelet Cou | 1994 |
A comparative clinical and pharmacokinetic study of a new slow-release versus conventional preparations of valproic acid in children with intractable epilepsy.
Topics: Adolescent; Child; Child, Preschool; Delayed-Action Preparations; Electroencephalography; Epilepsy; | 1992 |
72 other studies available for valproic acid and Thrombopenia
| Article | Year |
|---|---|
Aggravation of valproic acid induced thrombocytopenia after the introduction of fenfluramine, a case report.
Topics: Anemia; Anticonvulsants; Fenfluramine; Humans; Thrombocytopenia; Valproic Acid | 2021 |
Predicting the occurrence of thrombocytopenia from free valproate levels: A prospective study.
Topics: Anticonvulsants; Epilepsy; Humans; Prospective Studies; Thrombocytopenia; Valproic Acid | 2022 |
Assessment of need for hemostatic evaluation in patients taking valproic acid: A retrospective cross-sectional study.
Topics: Adolescent; Adult; Aged; Blood Coagulation Disorders; Child; Child, Preschool; Cross-Sectional Studi | 2022 |
Quetiapine-associated thrombocytopenic purpura in a young man with a first episode schizophrenia.
Topics: Adolescent; Adult; Antipsychotic Agents; Humans; Male; Purpura, Thrombocytopenic; Quetiapine Fumarat | 2023 |
Valproic Acid Serum Concentration and Incidence of Toxicity in Pediatric Patients.
Topics: Anticonvulsants; Child; Humans; Hyperammonemia; Incidence; Thrombocytopenia; Valproic Acid | 2022 |
Valproic Acid Induced Thrombocytopenia and Dysmegakaryopoiesis in a Pediatric Patient.
Topics: Aged; Anticonvulsants; Bone Marrow; Child; Female; Humans; Myelodysplastic Syndromes; Thrombocytopen | 2022 |
Valproic Acid Induced Thrombocytopenia in an Elderly Man with Schizoaffective Disorder: A Case Report.
Topics: Aged; Humans; Male; Psychotic Disorders; Thrombocytopenia; Valproic Acid | 2023 |
Radial Ray Malformation.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Amniocentesis; Amniotic Band Syndrome; Anal Ca | 2019 |
Case of significantly delayed divalproex-induced thrombocytopaenia.
Topics: Antimanic Agents; Bipolar Disorder; Humans; Male; Middle Aged; Thrombocytopenia; Time Factors; Valpr | 2019 |
Hypsarrhythmia and spasms resolution after Valproic acid discontinuation in an infantile spasm patient.
Topics: Anticonvulsants; Drug Administration Schedule; Female; Humans; Infant; Spasms, Infantile; Thrombocyt | 2019 |
Thrombocytopenia during intravenous valproic acid therapy in the neurological intensive care unit.
Topics: Administration, Intravenous; Aged; Anticonvulsants; Critical Illness; Dose-Response Relationship, Dr | 2020 |
Thrombocytopenia in pediatric patients on concurrent cannabidiol and valproic acid.
Topics: Adolescent; Anticonvulsants; Cannabidiol; Child; Child, Preschool; Drug Resistant Epilepsy; Drug The | 2020 |
Isolated severe thrombocytopenia in the setting of extreme hyperthermia.
Topics: Adult; Amphetamine-Related Disorders; Attention Deficit Disorder with Hyperactivity; Blood Platelets | 2020 |
Valproic Acid-Induced Thrombocytopenia-Related Spontaneous Systemic Bleeding.
Topics: Anemia; Female; Hemorrhage; Humans; Middle Aged; Thrombocytopenia; Valproic Acid | 2020 |
Decreased platelet count in children with epilepsy treated with valproate and its relationship to the immature platelet fraction.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Flow Cytometry; Humans; Infa | 2018 |
Chronic valproic acid intoxication.
Topics: Anticonvulsants; Cerebral Palsy; Chemistry, Pharmaceutical; Child; Chronic Disease; Developmental Di | 2013 |
Valproic acid and acquired coagulopathy.
Topics: Anticonvulsants; Blood Coagulation Disorders; Child; Humans; Perioperative Care; Thrombocytopenia; V | 2013 |
How I evaluate and treat thrombocytopenia in the intensive care unit patient.
Topics: Adolescent; Aged; Female; Heparin; Humans; Intensive Care Units; Male; Middle Aged; Platelet Transfu | 2016 |
Hematological effects of valproate in psychiatric patients: what are the risk factors?
Topics: Adolescent; Adult; Aged; Anemia, Macrocytic; Blood Cell Count; Cross-Sectional Studies; Female; Hema | 2010 |
[Acute valproic acid intoxication: interest of a treatment by extracoporeal elimination combined with L-carnitine].
Topics: Acidosis, Lactic; Acute Lung Injury; Anticonvulsants; Carnitine; Cranial Nerve Diseases; Electroence | 2011 |
Valproic Acid-related anticonvulsant hypersensitivity syndrome and subsequent olanzapine-related neutropenia and thrombocytopenia: a case report.
Topics: Adult; Anticonvulsants; Antimanic Agents; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; C | 2012 |
[Valproate (depakine chrono) in adult patients with partial epilepsy: results of a multicentral prospective non-comparative study].
Topics: Adolescent; Adult; Anticonvulsants; Epilepsies, Partial; Female; Gastrointestinal Diseases; Humans; | 2012 |
Thrombocytopenia and megakaryocyte dysplasia: an adverse effect of valproic acid treatment.
Topics: Blood Platelets; Bone Marrow; Cerebral Palsy; Child; Female; Humans; Megakaryocytes; Thrombocytopeni | 2002 |
EDTA-dependent pseudothrombocytopenia induced by valproic acid.
Topics: Anticonvulsants; Diagnostic Errors; Edetic Acid; Epilepsy; False Positive Reactions; Female; Heparin | 2003 |
Thrombocytopenia during valproic acid treatment in young patients with new-onset bipolar disorder.
Topics: Adult; Bipolar Disorder; Female; Humans; Male; Normal Distribution; Platelet Count; Prospective Stud | 2003 |
Efficiency of high-flux hemodialysis in the treatment of valproic acid intoxication.
Topics: Adult; Anticonvulsants; Humans; Male; Renal Dialysis; Suicide, Attempted; Thrombocytopenia; Valproic | 2003 |
Valproic-acid-induced thrombocytopenia and hepatotoxicity: discontinuation of treatment?
Topics: Anticonvulsants; Chemical and Drug Induced Liver Injury; Child, Preschool; Epilepsy, Generalized; Hu | 2004 |
Valproic acid-induced hyperammonemia and thrombocytopenia in an elderly woman.
Topics: Aged; Ammonia; Anticonvulsants; Female; Humans; Hyperammonemia; Platelet Count; Thrombocytopenia; Va | 2004 |
[Influence of psychotropic drugs on thrombocytes aggregation in patients with epilepsy].
Topics: Adolescent; Adult; Barbiturates; Carbamazepine; Epilepsy; Humans; In Vitro Techniques; Lamotrigine; | 2004 |
Macrocytosis associated with divalproex treatment.
Topics: Anemia, Macrocytic; Anticonvulsants; Bipolar Disorder; Child; Dose-Response Relationship, Drug; Eryt | 2005 |
Valproate-associated coagulopathies are frequent and variable in children.
Topics: Age Factors; Anticonvulsants; Blood Coagulation Tests; Child; Coagulation Protein Disorders; Epileps | 2006 |
Valproate-associated coagulopathies are frequent and variable in children.
Topics: Age Factors; Ambulatory Care; Anticonvulsants; Blood Coagulation Disorders; Child; Epilepsy; Female; | 2007 |
Sodium valproate and haemostasis--what to do.
Topics: Hemostasis; Humans; Thrombocytopenia; Valproic Acid | 1984 |
Sodium valproate and platelet counts.
Topics: Epilepsy; Humans; Platelet Count; Thrombocytopenia; Valproic Acid | 1980 |
Sodium valproate and bone marrow suppression.
Topics: Adult; Blood Coagulation Disorders; Bone Marrow Diseases; Epilepsies, Partial; Female; Humans; Throm | 1980 |
Valproic acid and thrombocytopenia.
Topics: Adolescent; Adult; Child, Preschool; Female; Humans; Male; Thrombocytopenia; Valproic Acid | 1981 |
[Complications of valproic acid therapy: an overview (author's transl)].
Topics: Adult; Alcohol Withdrawal Delirium; Chemical and Drug Induced Liver Injury; Child; Coma; Electroence | 1981 |
[Sodium valproate, platelet dysfunction and bleeding (author's transl)].
Topics: Blood Platelet Disorders; Epilepsy; Humans; Thrombocytopenia; Valproic Acid | 1981 |
Sodium valproate and thrombocytopenia.
Topics: Child; Dose-Response Relationship, Drug; Female; Humans; Seizures; Thrombocytopenia; Valproic Acid | 1982 |
[Clinical irrelevance of the hematologic side effects of sodium valproate (Depakine)].
Topics: Adult; Age Factors; Anticonvulsants; Autoantibodies; Blood Coagulation Disorders; Blood Platelets; C | 1981 |
Valproic acid and thrombocytopenia. Case report.
Topics: Child, Preschool; Humans; Male; Seizures; Thrombocytopenia; Valproic Acid | 1982 |
Valproic acid and immune thrombocytopenia.
Topics: Adolescent; Adult; Anticonvulsants; Blood Platelets; Child; Child, Preschool; Drug Therapy, Combinat | 1982 |
Blood dyscrasias with carbamazepine and valproate: a pharmacoepidemiological study of 2,228 patients at risk.
Topics: Adolescent; Adult; Anemia; Carbamazepine; Depressive Disorder; Desipramine; Drug Therapy, Combinatio | 1995 |
Haematological disturbances during long-term valproate therapy.
Topics: Adolescent; Anemia, Macrocytic; Dermatitis, Atopic; Humans; Male; Seizures; Thrombocytopenia; Valpro | 1994 |
Thrombocytopenia in association with adjunctive felbamate use.
Topics: Adult; Anticonvulsants; Drug Therapy, Combination; Felbamate; Humans; Male; Phenylcarbamates; Propyl | 1994 |
Changes in red blood cells with valproate therapy.
Topics: Anemia, Macrocytic; Blood Platelets; Epilepsy; Erythrocyte Indices; Erythrocyte Volume; Erythrocytes | 1993 |
Thrombocytopenia induced by noncytotoxic drugs in Denmark 1968-91.
Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Age Distribution; Aged; Aged, 80 and ove | 1996 |
Valproic acid and thrombocytopenia in children: a case-controlled retrospective study.
Topics: Adolescent; Adult; Anticonvulsants; Case-Control Studies; Child; Evaluation Studies as Topic; Female | 1996 |
Dose-related thrombocytopenia and macrocytic anemia associated with valproate use in bipolar disorder.
Topics: Anemia, Macrocytic; Bipolar Disorder; Drug Therapy, Combination; Female; Humans; Middle Aged; Myelod | 1997 |
[Side effects of anticonvulsants in the treatment of idiopathic generalized epilepsy].
Topics: Adolescent; Adult; Anticonvulsants; Barbiturates; Central Nervous System; Child; Child, Preschool; D | 1997 |
Dose-dependent valproic acid thrombocytopenia in bipolar disorder.
Topics: Anticonvulsants; Antimanic Agents; Bipolar Disorder; Dose-Response Relationship, Drug; Female; Human | 1998 |
Fatal pulmonary hemorrhage during high-dose valproate monotherapy.
Topics: Adult; Anticonvulsants; Epilepsy, Generalized; Fatal Outcome; Female; Hemorrhage; Humans; Lung Disea | 2000 |
Side effect profile of enteric-coated divalproex sodium versus valproic acid.
Topics: Humans; Male; Middle Aged; Nausea; Platelet Count; Tablets, Enteric-Coated; Thrombocytopenia; Valpro | 2000 |
Occurrence of thrombocytopenia in psychiatric patients taking valproate.
Topics: Age Factors; Aged; Anticonvulsants; Drug Monitoring; Female; Hospitalization; Humans; Male; Mental D | 2001 |
Nitroso-urea-cisplatin-based chemotherapy associated with valproate: increase of haematologic toxicity.
Topics: Adult; Aged; Anticonvulsants; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cispl | 2001 |
[Hyperammonia, hypoglycemia and thrombocytopenia in a newborn after materanl treatment with valproate].
Topics: Adult; Ammonia; Anticonvulsants; Female; Humans; Hypoglycemia; Infant, Newborn; Infant, Newborn, Dis | 2001 |
Valproic acid and thrombocytopenia: cross-sectional study.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Child; Child, Preschool; Cross-Sectional Studies; F | 2001 |
Severe, isolated thrombocytopenia under polytherapy with carbamazepine and valproate.
Topics: Aged; Anticonvulsants; Blood Platelets; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; | 2001 |
Prevalence and risk of thrombocytopenia with valproic acid: experience at a psychiatric teaching hospital.
Topics: Adolescent; Adult; Age Factors; Aged; Antimanic Agents; Chi-Square Distribution; Dose-Response Relat | 2001 |
Topiramate enhances the risk of valproate-associated side effects in three children.
Topics: Affective Symptoms; Anticonvulsants; Chemical and Drug Induced Liver Injury; Drug Therapy, Combinati | 2002 |
Sodium valproate and platelet-count.
Topics: Child; Epilepsy; Female; Humans; Male; Thrombocytopenia; Valerates; Valproic Acid | 1978 |
Sodium valproate and thrombocytopenia.
Topics: Child; Dose-Response Relationship, Drug; Epilepsy, Absence; Humans; Male; Thrombocytopenia; Valproic | 1979 |
[Antiepileptic therapy with valproinic acid. Correlations of side effects and serum levels of valproinic acid].
Topics: Acne Vulgaris; Anemia, Aplastic; Epilepsy; Fatigue; Gastrointestinal Diseases; Humans; Leukopenia; T | 1979 |
[Thrombocyte values in adults during the treatment with DPA (Ergenyl)].
Topics: Adolescent; Adult; Blood Platelets; Dose-Response Relationship, Drug; Epilepsy; Humans; Middle Aged; | 1977 |
Transient thrombocytopenia in a child on sodium valproate.
Topics: Child; Female; Humans; Remission, Spontaneous; Respiratory Tract Infections; Seizures; Thrombocytope | 1978 |
IgM platelet autoantibody due to sodium valproate.
Topics: Autoantibodies; Autoimmune Diseases; Blood Platelets; Child; Humans; Immunoglobulin M; Male; Thrombo | 1978 |
Thrombocytopenia associated with sodium valproate treatment.
Topics: Adult; Aged; Humans; Middle Aged; Thrombocytopenia; Valproic Acid | 1979 |
[Alterations in hemostasis during treatment with sodium dipropylacetate (Depakine) (R)].
Topics: Blood Coagulation Disorders; Child; Child, Preschool; Female; Hemostasis; Humans; Infant; Male; Thro | 1979 |
[Changes in hemostasis during epilespy treatment using dipropyl acetate. Extended study].
Topics: Adolescent; Blood Cell Count; Blood Platelets; Child; Child, Preschool; Epilepsy; Factor IX; Female; | 1976 |
Sodium valproate and thrombocytopenia.
Topics: Blood Cell Count; Blood Platelets; Child; Humans; Male; Thrombocytopenia; Valerates; Valproic Acid | 1976 |
[Thrombocyte values during ergenyl treatment].
Topics: Anticonvulsants; Blood Cell Count; Blood Platelets; Child; Child, Preschool; Epilepsy; Humans; Throm | 1975 |
[A case of thrombocytopenia with antiplatelet autoantibody after sodium valproate administration--with statistical analysis of 33 cases administrated sodium valproate].
Topics: Adolescent; Adult; Aged; Autoantibodies; Blood Platelets; Child; Humans; Immunoglobulin G; Male; Mid | 1987 |