valproic acid has been researched along with Teratogenesis in 14 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Teratogenesis: The formation of CONGENITAL ABNORMALITIES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Valproic acid (VPA) is a widely prescribed antiepileptic drug with various medicinal efficacies." | 5.91 | Toxicity and teratogenicity effects of valproic acid on zebrafish (Danio rerio) embryos in relation to autism spectrum disorder. ( Azmai, MNA; Bakar, NA; Chong, SG; Fadzar, MSIM; Fahmi, MSAM; Faudzi, SMM; Hamid, NNAZZ; Ibrahim, WNW; Mastuki, SN; Norazhar, AI; Ramlan, NF; Saleh Hodin, NA; Zulkifli, AR, 2023) |
| "Valproic acid is a widely-used first-generation antiepileptic drug, prescribed predominantly in epilepsy and psychiatric disorders." | 4.89 | Adverse drug reactions induced by valproic acid. ( Nanau, RM; Neuman, MG, 2013) |
| "Valproic acid (VPA), a prescribed drug commonly used for various neurological perturbations, has been implicated in teratogenic inflictions on developing fetuses during pregnancy." | 4.12 | Valproic acid induced selective apoptosis of ocular fibrous tunic in mice fetuses. ( Avramidou, E; Dermitzakis, I; Emmanouil-Nikoloussi, EN; Manthos, K; Manthou, ME; Meditskou, S; Theotokis, P, 2022) |
| "For patients with migraine, the pregnancy labeling of VPA will be changed from Category "D" to "X." | 2.50 | Risks of neurobehavioral teratogenicity associated with prenatal exposure to valproate monotherapy: a systematic review with regulatory repercussions. ( Gentile, S, 2014) |
| "Valproic acid (VPA) is an anti-epileptic drug used alone or in combination with other medications to treat seizures, mania, and bipolar disorder." | 1.91 | Sodium valproate exposure influences the expression of pparg in the zebrafish model. ( Benedetti, E; Caioni, G; Cimini, A; Merola, C; Perugini, M, 2023) |
| "Comorbid diagnosis of headache predicted use of topiramate and VPA, bipolar disease predicted use of LMT and VPA, pain predicted gabapentin, and schizophrenia was associated with VPAs use." | 1.91 | Prescribing Trends of Antiseizure Drugs in Women Veterans With Epilepsy. ( Amuan, ME; Henion, A; Lopez, MR; Panahi, S; Pugh, MJ; VanCott, AC, 2023) |
| "Valproic acid (VPA) is a widely prescribed antiepileptic drug with various medicinal efficacies." | 1.91 | Toxicity and teratogenicity effects of valproic acid on zebrafish (Danio rerio) embryos in relation to autism spectrum disorder. ( Azmai, MNA; Bakar, NA; Chong, SG; Fadzar, MSIM; Fahmi, MSAM; Faudzi, SMM; Hamid, NNAZZ; Ibrahim, WNW; Mastuki, SN; Norazhar, AI; Ramlan, NF; Saleh Hodin, NA; Zulkifli, AR, 2023) |
| " We conclude that the PluriBeat assay is a novel method for predicting chemicals' adverse effects on embryonic development." | 1.56 | A novel human pluripotent stem cell-based assay to predict developmental toxicity. ( Emnéus, JK; Holst, B; Lauschke, K; Meiser, I; Neubauer, JC; Rasmussen, MA; Rosenmai, AK; Schmidt, K; Taxvig, C; Vinggaard, AM, 2020) |
| "Significant decreases in pregnancy weight gain and the number of live fetuses were observed when VPA was administered at the high dose, whereas the percentage of exencephalic fetuses was significantly increased in VPA treated compared with an equivalent VCD dosage group." | 1.51 | Teratogenicity of valproic acid and its constitutional isomer, amide derivative valnoctamide in mice. ( Bialer, M; Cabrera, RM; Finnell, RH; Lin, YL; Wlodarczyk, BJ, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 9 (64.29) | 24.3611 |
| 2020's | 5 (35.71) | 2.80 |
| Authors | Studies |
|---|---|
| Manthos, K | 1 |
| Theotokis, P | 1 |
| Dermitzakis, I | 1 |
| Avramidou, E | 1 |
| Meditskou, S | 1 |
| Manthou, ME | 1 |
| Emmanouil-Nikoloussi, EN | 1 |
| Merola, C | 1 |
| Caioni, G | 1 |
| Cimini, A | 1 |
| Perugini, M | 1 |
| Benedetti, E | 1 |
| Lopez, MR | 1 |
| VanCott, AC | 1 |
| Amuan, ME | 1 |
| Panahi, S | 1 |
| Henion, A | 1 |
| Pugh, MJ | 1 |
| Saleh Hodin, NA | 1 |
| Chong, SG | 1 |
| Bakar, NA | 1 |
| Fahmi, MSAM | 1 |
| Ramlan, NF | 1 |
| Hamid, NNAZZ | 1 |
| Fadzar, MSIM | 1 |
| Zulkifli, AR | 1 |
| Norazhar, AI | 1 |
| Mastuki, SN | 1 |
| Faudzi, SMM | 1 |
| Ibrahim, WNW | 1 |
| Azmai, MNA | 1 |
| Lauschke, K | 1 |
| Rosenmai, AK | 1 |
| Meiser, I | 1 |
| Neubauer, JC | 1 |
| Schmidt, K | 1 |
| Rasmussen, MA | 1 |
| Holst, B | 1 |
| Taxvig, C | 1 |
| Emnéus, JK | 1 |
| Vinggaard, AM | 1 |
| Lamparter, CL | 1 |
| Philbrook, NA | 1 |
| Winn, LM | 1 |
| Angus-Leppan, H | 1 |
| Shankar, R | 1 |
| Cock, H | 1 |
| Lin, YL | 1 |
| Bialer, M | 1 |
| Cabrera, RM | 1 |
| Finnell, RH | 1 |
| Wlodarczyk, BJ | 1 |
| Nanau, RM | 1 |
| Neuman, MG | 1 |
| Lee, SH | 1 |
| Kang, JW | 1 |
| Lin, T | 1 |
| Lee, JE | 1 |
| Jin, DI | 1 |
| Hsieh, CL | 1 |
| Chen, KC | 1 |
| Lin, PX | 1 |
| Peng, CC | 1 |
| Peng, RY | 1 |
| Gentile, S | 1 |
| Ehashi, T | 1 |
| Suzuki, N | 1 |
| Ando, S | 1 |
| Sumida, K | 1 |
| Saito, K | 1 |
| Tomson, T | 1 |
| Battino, D | 1 |
| Bonizzoni, E | 1 |
| Craig, J | 1 |
| Lindhout, D | 1 |
| Perucca, E | 1 |
| Sabers, A | 1 |
| Thomas, SV | 1 |
| Vajda, F | 1 |
2 reviews available for valproic acid and Teratogenesis
| Article | Year |
|---|---|
Adverse drug reactions induced by valproic acid.
Topics: Anticonvulsants; Antipsychotic Agents; Drug Hypersensitivity; Endocrine System; Epilepsy; Humans; Hy | 2013 |
Risks of neurobehavioral teratogenicity associated with prenatal exposure to valproate monotherapy: a systematic review with regulatory repercussions.
Topics: Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Autism Spectrum Disorder; Bipolar Di | 2014 |
12 other studies available for valproic acid and Teratogenesis
| Article | Year |
|---|---|
Valproic acid induced selective apoptosis of ocular fibrous tunic in mice fetuses.
Topics: Animals; Apoptosis; Female; Fetus; In Situ Nick-End Labeling; Mice; Mice, Inbred BALB C; Pregnancy; | 2022 |
Sodium valproate exposure influences the expression of pparg in the zebrafish model.
Topics: Animals; PPAR gamma; Teratogenesis; Teratogens; Valproic Acid; Zebrafish; Zebrafish Proteins | 2023 |
Prescribing Trends of Antiseizure Drugs in Women Veterans With Epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Epilepsy; Female; Gabapentin; Humans; Lamotrigine; Levetiracetam | 2023 |
Toxicity and teratogenicity effects of valproic acid on zebrafish (Danio rerio) embryos in relation to autism spectrum disorder.
Topics: Animals; Anticonvulsants; Autism Spectrum Disorder; Behavior, Animal; Teratogenesis; Teratogens; Val | 2023 |
A novel human pluripotent stem cell-based assay to predict developmental toxicity.
Topics: Biological Assay; Cell Line; Developmental Biology; Embryoid Bodies; Epoxy Compounds; Female; Humans | 2020 |
Valproic acid increases NF-κB transcriptional activation despite decreasing DNA binding ability in P19 cells, which may play a role in VPA-initiated teratogenesis.
Topics: Animals; Anticonvulsants; Cell Line, Tumor; DNA; Mice; NF-kappa B; RNA, Messenger; Teratogenesis; Tr | 2017 |
Valproate, women, and exceptional circumstances.
Topics: Anticonvulsants; Drug Prescriptions; Drug Utilization; Epilepsy; Female; Humans; Pregnancy; Teratoge | 2018 |
Teratogenicity of valproic acid and its constitutional isomer, amide derivative valnoctamide in mice.
Topics: Abnormalities, Drug-Induced; Amides; Animals; Anticonvulsants; Female; Fetal Death; Fetus; Mice; Neu | 2019 |
Teratogenic potential of antiepileptic drugs in the zebrafish model.
Topics: Acetamides; Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Ethosuximide; Female; F | 2013 |
Resveratrol and vitamin E rescue valproic acid-induced teratogenicity: the mechanism of action.
Topics: Abnormalities, Drug-Induced; Animals; Antioxidants; Chick Embryo; Glutathione; Reactive Oxygen Speci | 2014 |
Effects of valproic acid on gene expression during human embryonic stem cell differentiation into neurons.
Topics: Animals; Anticonvulsants; Cell Differentiation; Cells, Cultured; Doublecortin Domain Proteins; Doubl | 2014 |
Dose-dependent teratogenicity of valproate in mono- and polytherapy: an observational study.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Dose-Response Relationship, Drug; D | 2015 |