valproic acid has been researched along with Tension-Type Headache in 8 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Tension-Type Headache: A common primary headache disorder, characterized by a dull, non-pulsatile, diffuse, band-like (or vice-like) PAIN of mild to moderate intensity in the HEAD; SCALP; or NECK. The subtypes are classified by frequency and severity of symptoms. There is no clear cause even though it has been associated with MUSCLE CONTRACTION and stress. (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)
| Excerpt | Relevance | Reference |
|---|---|---|
| " For the acute treatment of migraine attacks or tension-type headache, ibuprofen (10 mg per kg body weight) or acetaminophen (15 mg per kg body weight) are recommended with highest evidence, intranasal sumatriptan (10 to 20 mg) can be given as second choice." | 4.81 | [Treatment of idiopathic headache in childhood - recommendations of the German Migraine and Headache Society (DMKG)]. ( Evers, S; Gerber, WD; Naumann, E; Pothmann, R; Uberall, M, 2002) |
| "Sixty percent of migraineurs had a 75% or more improvement in the number of headache days under sodium valproate, most of the remaining attacks being less severe." | 2.68 | Sodium valproate in severe migraine and tension-type headache: an open study of long-term efficacy and correlation with blood levels. ( Bastings, E; Lenaerts, M; Schoenen, J; Sianard, J, 1996) |
| "Propranolol was comparable to other medications known to be effective including flunarizine, topiramate and valproate." | 2.61 | Beta-blockers for the prevention of headache in adults, a systematic review and meta-analysis. ( Hayashino, Y; Jackson, JL; Jackson, W; Kuriyama, A; Kuwatsuka, Y; Nickoloff, S; Storch, D; Zhang, ZJ, 2019) |
| "Headaches are a common entity in the ambulatory population." | 2.40 | Diagnosis, prophylaxis, and treatment of headaches in the athlete. ( Kaplan, B; Swain, RA, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 5 (62.50) | 29.6817 |
| 2010's | 1 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jackson, JL | 1 |
| Kuriyama, A | 1 |
| Kuwatsuka, Y | 1 |
| Nickoloff, S | 1 |
| Storch, D | 1 |
| Jackson, W | 1 |
| Zhang, ZJ | 1 |
| Hayashino, Y | 1 |
| Maggioni, F | 1 |
| Ruffatti, S | 1 |
| Dainese, F | 1 |
| Mainardi, F | 1 |
| Zanchin, G | 1 |
| Yurekli, VA | 1 |
| Akhan, G | 1 |
| Kutluhan, S | 1 |
| Uzar, E | 1 |
| Koyuncuoglu, HR | 1 |
| Gultekin, F | 1 |
| Lenaerts, M | 1 |
| Bastings, E | 1 |
| Sianard, J | 1 |
| Schoenen, J | 1 |
| Swain, RA | 1 |
| Kaplan, B | 1 |
| Freitag, FG | 1 |
| Diamond, S | 1 |
| Diamond, ML | 1 |
| Urban, GJ | 1 |
| Evers, S | 1 |
| Pothmann, R | 1 |
| Uberall, M | 1 |
| Naumann, E | 1 |
| Gerber, WD | 1 |
| Solomon, GD | 1 |
4 reviews available for valproic acid and Tension-Type Headache
| Article | Year |
|---|---|
Beta-blockers for the prevention of headache in adults, a systematic review and meta-analysis.
Topics: Adrenergic beta-Antagonists; Adult; Clinical Trials as Topic; Female; Humans; Male; Migraine Disorde | 2019 |
Diagnosis, prophylaxis, and treatment of headaches in the athlete.
Topics: Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents, Tricyclic; | 1997 |
[Treatment of idiopathic headache in childhood - recommendations of the German Migraine and Headache Society (DMKG)].
Topics: Acetaminophen; Adrenergic beta-Antagonists; Age Factors; Analgesics, Non-Narcotic; Biofeedback, Psyc | 2002 |
Chronic tension-type headache: advice for the viselike-headache patient.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents, Tricyclic; Biofeedback, Psychology; | 2002 |
3 trials available for valproic acid and Tension-Type Headache
| Article | Year |
|---|---|
Weight variations in the prophylactic therapy of primary headaches: 6-month follow-up.
Topics: Adrenergic beta-Antagonists; Adult; Amines; Amitriptyline; Analgesics, Non-Narcotic; Anticonvulsants | 2005 |
The effect of sodium valproate on chronic daily headache and its subgroups.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Chronic Disease; Double-Blind Method; Female; Headache Dis | 2008 |
Sodium valproate in severe migraine and tension-type headache: an open study of long-term efficacy and correlation with blood levels.
Topics: Adult; Anticonvulsants; Female; Follow-Up Studies; Humans; Male; Middle Aged; Migraine Disorders; Pa | 1996 |
1 other study available for valproic acid and Tension-Type Headache
| Article | Year |
|---|---|
Divalproex in the long-term treatment of chronic daily headache.
Topics: Adult; Body Weight; Female; Headache Disorders; Humans; Male; Migraine Disorders; Retrospective Stud | 2001 |