valproic acid and Syndrome studies

Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.

Research Excerpts

Excerpt	Relevance	Reference
"We studied the efficacy of felbamate (FBM) in combination with valproic acid (VPA) in 13 patients with the Lennox-Gastaut syndrome and evaluated the contribution of each drug."	9.09	The efficacy of felbamate as add-on therapy to valproic acid in the Lennox-Gastaut syndrome. ( Flamini, R; Gaillard, WD; Kelley, K; Ko, D; Malow, B; Reeves-Tyer, P; Siegel, H; Stertz, B; Theodore, WH, 1999)
"A number of preclinical studies and preliminary clinical reports, in some cases augmented by controlled studies, suggest that valproate and carbamazepine may have therapeutic effects in the treatment of certain anxiety disorders (panic disorder, post-traumatic stress disorder), alcohol and sedative-hypnotic withdrawal states, and behavioral dyscontrol syndromes."	8.78	Valproate and carbamazepine in the treatment of panic and posttraumatic stress disorders, withdrawal states, and behavioral dyscontrol syndromes. ( Friedman, LM; Keck, PE; McElroy, SL, 1992)
"Stiripentol is an antiepileptic drug (AED) approved by the European Medicines Agency for the treatment of Dravet Syndrome (DS) as adjunct treatment with valproate and clobazam."	7.81	Extending the use of stiripentol to other epileptic syndromes: a case of PCDH19-related epilepsy. ( Specchio, N; Trivisano, M; Vigevano, F, 2015)
"We describe four children with Dravet syndrome treated with the combination of valproic acid (VPA) and topiramate (TPM) who developed transient liver toxicity."	7.74	Acute hepatic injury in four children with Dravet syndrome: valproic acid, topiramate or acetaminophen? ( Ceulemans, B; Gunning, B; Leroy, PL; Nicolai, J; Vles, JS, 2008)
" However, he was found to have hyperammonemia within 2 weeks after the addition of low-dose topiramate to valproate."	7.73	Topiramate-valproate-induced hyperammonemic encephalopathy syndrome: case report. ( Cheung, E; Fung, CW; Wong, V, 2005)
"We report on a 4-year 8-month-old boy with Panayiotopoulos syndrome who showed atypical evolution with newly developed absence seizures and EEG exacerbation induced by carbamazepine."	7.73	EEG and seizure exacerbation induced by carbamazepine in Panayiotopoulos syndrome. ( Akiyama, T; Endoh, F; Ito, M; Kikumoto, K; Ohtsuka, Y; Oka, M; Yoshinaga, H, 2006)
"In the past 6 years, 11 children on valproic acid have developed pancreatitis in our children's hospital."	7.72	Valproic acid-induced pancreatitis in childhood epilepsy: case series and review. ( Berg, M; Breault, R; Sinclair, DB, 2004)
"We present a patient with early infantile epileptic encephalopathy with suppression bursts (Ohtahara syndrome) with an excellent response to chloral hydrate to draw attention to a possible role of the "old" drug in the treatment of intractable epilepsy."	7.71	Successful treatment of Ohtahara syndrome with chloral hydrate. ( Komárek, V; Krsek, P; Maulisová, A; Procházka, T; Sebronová, V, 2002)
"Exposure in pregnancy is associated with approximately three-fold increase in the rate of major anomalies, mainly spina bifida and only rarely anencephaly (NTD), cardiac, craniofacial, skeletal and limb defects and a possible set of dysmorphic features, the "valproate syndrome" with decreased intrauterine growth."	6.45	Valproic acid in pregnancy: how much are we endangering the embryo and fetus? ( Ornoy, A, 2009)
"We studied the efficacy of felbamate (FBM) in combination with valproic acid (VPA) in 13 patients with the Lennox-Gastaut syndrome and evaluated the contribution of each drug."	5.09	The efficacy of felbamate as add-on therapy to valproic acid in the Lennox-Gastaut syndrome. ( Flamini, R; Gaillard, WD; Kelley, K; Ko, D; Malow, B; Reeves-Tyer, P; Siegel, H; Stertz, B; Theodore, WH, 1999)
"The drug encorat, an analogue of valproic acid (Sun, India) was given to 16 children aged from 4 month to 5 years suffering from resistant forms of early infantile epilepsy."	5.07	[The enkorat treatment of infantile spasms and the Lennox-Gastaut syndrome]. ( Badalian, LO; Iskander, MB; Kharlamov, DA; Medvedev, MI; Mukhin, KIu; Temin, PA; Veselov, NK, 1994)
" Moreover, the combination of magnesium valproate and carbamazepine could significantly reduce the frequency and duration of seizures, despite not eliminating them completely."	5.01	A potential cause of adolescent onset Dyke-Davidoff-Masson syndrome: A case report. ( Jiang, Z; Li, B; Li, J; Li, Y; Wang, L; Zhang, T, 2019)
"A number of preclinical studies and preliminary clinical reports, in some cases augmented by controlled studies, suggest that valproate and carbamazepine may have therapeutic effects in the treatment of certain anxiety disorders (panic disorder, post-traumatic stress disorder), alcohol and sedative-hypnotic withdrawal states, and behavioral dyscontrol syndromes."	4.78	Valproate and carbamazepine in the treatment of panic and posttraumatic stress disorders, withdrawal states, and behavioral dyscontrol syndromes. ( Friedman, LM; Keck, PE; McElroy, SL, 1992)
"We have evaluated 19 children who were exposed to valproic acid (VPA) in utero to look for manifestations of a fetal valproate syndrome (FVS), as proposed by Di Liberti et al."	4.77	Verification of the fetal valproate syndrome phenotype. ( Ardinger, HH; Atkin, JF; Blackston, RD; Clarren, SK; Elsas, LJ; Flannery, DB; Harrod, MJ; Lammer, EJ; Livingstone, S; Pellock, JM, 1988)
"Stiripentol is an antiepileptic drug (AED) approved by the European Medicines Agency for the treatment of Dravet Syndrome (DS) as adjunct treatment with valproate and clobazam."	3.81	Extending the use of stiripentol to other epileptic syndromes: a case of PCDH19-related epilepsy. ( Specchio, N; Trivisano, M; Vigevano, F, 2015)
"We describe four children with Dravet syndrome treated with the combination of valproic acid (VPA) and topiramate (TPM) who developed transient liver toxicity."	3.74	Acute hepatic injury in four children with Dravet syndrome: valproic acid, topiramate or acetaminophen? ( Ceulemans, B; Gunning, B; Leroy, PL; Nicolai, J; Vles, JS, 2008)
"Aromatic anticonvulsant agents such as carbamazepine and phenytoin can induce anticonvulsant hypersensitivity syndrome (AHS) at a frequency of 1 in 10,000 to 1 in 1,000 treated patients."	3.73	Anticonvulsant hypersensitivity syndrome: cross-reactivity with tricyclic antidepressant agents. ( Bröcker, EB; Pfeuffer, P; Raith, P; Seitz, CS; Trautmann, A, 2006)
"Fetal Valproate Syndrome results from prenatal exposure to valproic acid."	3.73	Fetal valproate syndrome. ( Kulkarni, ML; Shenoy, N; Vani, HN; Zaheeruddin, M, 2006)
"Valproate embryopathy is a well recognized syndrome caused by prenatal exposure to the anticonvulsant valproic acid (Depakote)."	3.73	Valproate embryopathy: clinical and cognitive profile in 5 siblings. ( Oppenheimer, SG; Saal, HM; Schorry, EK, 2005)
"We report on a 4-year 8-month-old boy with Panayiotopoulos syndrome who showed atypical evolution with newly developed absence seizures and EEG exacerbation induced by carbamazepine."	3.73	EEG and seizure exacerbation induced by carbamazepine in Panayiotopoulos syndrome. ( Akiyama, T; Endoh, F; Ito, M; Kikumoto, K; Ohtsuka, Y; Oka, M; Yoshinaga, H, 2006)
" However, he was found to have hyperammonemia within 2 weeks after the addition of low-dose topiramate to valproate."	3.73	Topiramate-valproate-induced hyperammonemic encephalopathy syndrome: case report. ( Cheung, E; Fung, CW; Wong, V, 2005)
"In the past 6 years, 11 children on valproic acid have developed pancreatitis in our children's hospital."	3.72	Valproic acid-induced pancreatitis in childhood epilepsy: case series and review. ( Berg, M; Breault, R; Sinclair, DB, 2004)
"We present a patient with early infantile epileptic encephalopathy with suppression bursts (Ohtahara syndrome) with an excellent response to chloral hydrate to draw attention to a possible role of the "old" drug in the treatment of intractable epilepsy."	3.71	Successful treatment of Ohtahara syndrome with chloral hydrate. ( Komárek, V; Krsek, P; Maulisová, A; Procházka, T; Sebronová, V, 2002)
"A full-term baby was born to an epileptic mother treated with two anti-epileptic drugs, sodium valproate and phenobarbital, throughout the pregnancy."	3.70	[A case of fetal valproate syndrome with intractable wheezing due to submucosal tumor below the vocal cord]. ( Adachi, M; Ai, Y; Maeda, E, 1999)
" We report a drug hypersensitivity syndrome in a 6-year-old Tunisian child treated for epileptic absences with sodium valproate and ethosuximide."	3.70	Hypersensitivity syndrome due to 2 anticonvulsant drugs. ( Conilleau, V; Dompmartin, A; Leroy, D; Michel, M; Verneuil, L, 1999)
"We report on a newborn baby, exposed to valproic acid in utero, with the typical dysmorphic features of the fetal valproate syndrome and omphalocele."	3.69	Omphalocele in a newborn baby exposed to sodium valproate in utero. ( Berthier, M; Bonneau, D; Boussemart, T; Levard, G; Oriot, D, 1995)
"Post-hypoxic myoclonus (PHM) is a rare neurological complication having two different variants depending on acute or chronic onset after cardiopulmonary resuscitation following cardiac arrest: myoclonic status epilepticus (MSE) and Lance-Adams syndrome (LAS) respectively."	3.01	Post-hypoxic myoclonus; what we know and gaps in knowledge. ( Ahmed, HS, 2023)
"Vomiting was severe enough in all patients to cause dehydration requiring hospitalization for intravenous rehydration."	2.74	Effective prophylactic therapy for cyclic vomiting syndrome in children using valproate. ( Amakata, K; Fujii, Y; Hikita, T; Kaga, F; Kaneko, S; Kodama, H; Nakamoto, N; Ogita, K; Yanagawa, Y, 2009)
"Carbamazepine (CBZ) was found to be effective in most cases."	2.61	Epilepsy in patients with EAST syndrome caused by mutation in the KCNJ10. ( Albaradie, R; Alhazmi, R; Alkhaldi, H; Chaudhary, M; Housawi, Y; Mir, A, 2019)
"The association between the two migraine variants (abdominal migraine and Alice in Wonderland Syndrome) might have clinical, pathophysiological and management implications."	2.46	A migraine variant with abdominal colic and Alice in Wonderland syndrome: a case report and review. ( Hamed, SA, 2010)
"Exposure in pregnancy is associated with approximately three-fold increase in the rate of major anomalies, mainly spina bifida and only rarely anencephaly (NTD), cardiac, craniofacial, skeletal and limb defects and a possible set of dysmorphic features, the "valproate syndrome" with decreased intrauterine growth."	2.45	Valproic acid in pregnancy: how much are we endangering the embryo and fetus? ( Ornoy, A, 2009)
"Most idiopathic generalized epilepsy (IGE) begins in childhood."	2.43	Management guidelines for children with idiopathic generalized epilepsy. ( Camfield, C; Camfield, P, 2005)
"Susac syndrome is an occlusive arteriolar disease that provokes infarcts in the cochlea, retina, and brain of young subjects, mostly women."	2.40	Susac syndrome. ( Aumaitre, O; Biousse, V; Bousser, MG; Fardeau, C; Godeau, P; Huong, DL; Lehoang, P; N'Guyen, N; Papo, T; Piette, JC, 1998)
"The most common syndrome is childhood absence epilepsy; it usually occurs in the age range of 6-7 years."	2.38	The absence epilepsies. ( Porter, RJ, 1993)
" These deal mainly with biochemical systems that are known to be affected by VPA, or with the possible idiosyncratic production of toxic VPA metabolites, especially delta 4-VPA."	2.38	Valproate hepatotoxicity syndrome: hypotheses of pathogenesis. ( Levy, RH; Stephens, JR, 1992)
"Among psychiatric disorders the acute symptoms of schizophrenia are exacerbated by enhanced GABA-ergic function."	2.36	Pharmacology of GABA. ( Meldrum, B, 1982)
"The patient had initial seizures during sleep at the age of 1 year, with the left mouth pouting, left eye blinking and drooling for several seconds, and, sometimes, the left upper-limb flexion and head version to the left, lasting for 1-2 min."	1.51	Acquired epileptiform opercular syndrome evaluated with real-time transcranial Doppler ultrasound-video-electroencephalogram before and after treatment: a case report. ( Chen, WX; Li, JL; Liang, HC; Liang, W; Peng, BW; Yang, SY; Zhang, FQ, 2019)
"Early after CA, myoclonus together with a reactive, epileptiform EEG, preserved evoked potentials and brainstem reflexes suggests LAS."	1.46	Early Lance-Adams syndrome after cardiac arrest: Prevalence, time to return to awareness, and outcome in a large cohort. ( Aicua Rapun, I; Novy, J; Oddo, M; Rossetti, AO; Solari, D, 2017)
"Malignant migrating partial seizures in infancy (MMPSI) or Coppola-Dulac syndrome is a rare epilepsy syndrome with the onset in the first 6 months of life, characterized by multiple continuous electroencephalographic and electroclinical focal ictal patterns due to the involvement of different independent areas of both hemispheres with the arrest of psychomotor development."	1.39	[The syndrome of malignant migrating partial seizures in infancy or Coppola-Dulac syndrome (19 cases)]. ( Kholin, AA, 2013)
"Jeavons syndrome is one of the idiopathic generalized epilepsies characterized by EM with or without absence."	1.38	[Clinical and electroencephalographic characteristics of Jeavons syndrome]. ( Liu, XY; Qin, J; Yang, ZX; Zhang, YH, 2012)
"DRESS syndrome was suspected in the patient, and she was taken off sodium valproate and tetradox; N-acetylcysteine, ceftriaxon, prednizolone, and support treatment were started."	1.38	DRESS syndrome with fatal results induced by sodium valproate in a patient with brucellosis and a positive cytoplasmic antineutrophilic cytoplasmic antibody test result. ( Albayrak, A; Albayrak, F; Cerrah, S; Dursun, H; Uyanik, A; Yildirim, R, 2012)
"All patients suffered from seizures during wakefulness."	1.36	Benign infantile focal epilepsy with midline spikes and waves during sleep: a new epileptic syndrome or a variant of benign focal epilepsy? ( Caraballo, R; Cersósimo, R; Flesler, S; Sakr, D, 2010)
"Opsoclonus-myoclonus-ataxia syndrome (OMS) is a rare neurological disorder of probably autoimmune origin."	1.35	Opsoclonus-myoclonus-ataxia syndrome with autoantibodies to glutamic acid decarboxylase. ( Alexiou, E; Gekas, G; Markakis, I; Rombos, A; Xifaras, M, 2008)
"Epilepsy is often the most important clinical manifestation of the syndrome, even if its appearance is not constantly precocious."	1.35	Ring chromosome 20 syndrome: a link between epilepsy onset and neuropsychological impairment in three children. ( Canevini, MP; Dalla Bernardina, B; Darra, F; Fiorini, E; La Selva, L; Lazzarotto, F; Piazzini, A; Vignoli, A; Zucca, C, 2009)
"Although epilepsy in AS is considered a generalized epilepsy, there was a high prevalence of partial seizures."	1.35	Epilepsy in Angelman syndrome: a questionnaire-based assessment of the natural history and current treatment options. ( Braun, EK; Bruno, P; Conant, KD; Nespeca, MP; Said, RR; Thibert, RL; Thiele, EA, 2009)
"Non-treated homozygous polydactyly/arhinencephaly (Pdn/Pdn) mouse fetuses exhibited exencephaly in 16."	1.33	Exencephaly induction by valproic acid in the genetic polydactyly/arhinencephaly mouse, Pdn/Pdn. ( Katagiri, R; Maekawa, M; Naruse, I; Ohta, K; Ueta, E, 2005)
"A patient meeting DSM-IV criteria for bipolar mood disorder, mixed type with psychotic feature had the delusion of being transformed into a dog."	1.33	Co-existence of lycanthropy and Cotard's syndrome in a single case. ( Nejad, AG; Toofani, K, 2005)
"Three times acute cardiopulmonary arrest appeared during status asthmaticus."	1.33	[Lance-Adams syndrome in patient with anoxic encephalopathy in the course of bronchial asthma]. ( Budrewicz, SP; Koszewicz, MA; Kowalczyk, EE; Podemski, R; Słotwiński, K, 2006)
"This syndrome is accompanied by fever, rash, lymphadenopathy, eosinophilia and affects parenchymal organs."	1.32	[Anticonvulsant hypersensitivity syndrome]. ( Papp, Z; Török, L, 2004)
"All patients met DSM-IV criteria for a disruptive behavior disorder (oppositional defiant disorder of conduct disorder) in addition to research criteria."	1.32	"Outer-directed irritability": a distinct mood syndrome in explosive youth with a disruptive behavior disorder? ( Donovan, SJ; Jensen, PS; Klein, DF; Nunes, EV; Quitkin, FM; Ross, D; Stewart, JW, 2003)
"Autism has been described in association with a variety of medical and genetic conditions."	1.31	Fetal valproate syndrome and autism: additional evidence of an association. ( Cunningham, M; Hersh, JH; Kerr, B; King, J; Stephan, M; Williams, G, 2001)
"Valproic acid was proved to be effective in reducing the number of attacks over 4 months."	1.30	Periodic discharge of adrenocorticotropin and vasopressin associated with focal glomerulosclerosis. ( Fujieda, M; Kurashige, T; Machida, Y; Maeda, A; Maeda, H; Naruse, K; Okada, T; Ushida, M; Wakiguchi, H; Yokoyama, W, 1998)
"A child with primary ciliary dyskinesia syndrome (PCDS) developed primary generalised epilepsy (PGE)."	1.30	Primary ciliary dyskinesia syndrome and primary generalised epilepsy. ( Shepherd, RC, 1999)
"From a series of 1,713 patients with craniosynostosis hospitalized between 1976 and 1996, 237 propositi with metopic synostosis were analyzed."	1.30	Syndromal and nonsyndromal primary trigonocephaly: analysis of a series of 237 patients. ( Lajeunie, E; Le Merrer, M; Marchac, D; Renier, D, 1998)
"One also had features of infantile autism."	1.29	Fetal valproate syndrome: clinical and neuro-developmental features in two sibling pairs. ( Chesler, N; Christianson, AL; Kromberg, JG, 1994)

Research

Studies (128)

Authors

Clinical Trials (2)

Trial Overview

Trial Outcomes

Change in Number of Absence Seizures From Week 8 (Baseline) to Week 12

Timeframe	Studies, this research(%)	All Research%
pre-1990	14 (10.94)	18.7374
1990's	25 (19.53)	18.2507
2000's	60 (46.88)	29.6817
2010's	25 (19.53)	24.3611
2020's	4 (3.13)	2.80

Authors	Studies
Viamontes, CG	1
Castillo Gonzalez, J	1
Najjar, F	1
Cook, EH	1
Zhang, J	1
Gan, J	1
Wang, J	1
Ahmed, HS	1
Li, Y	1
Zhang, T	1
Li, B	1
Li, J	1
Wang, L	1
Jiang, Z	1
Marcellino, C	1
Wijdicks, EF	1
Aicua Rapun, I	1
Novy, J	1
Solari, D	1
Oddo, M	1
Rossetti, AO	1
Wiedemann, K	1
Stüber, T	1
Rehn, M	1
Frieauff, E	1
Mohd Yunos, H	1
Green, A	1
Morris, JK	1
Garne, E	1
Loane, M	1
Addor, MC	1
Barisic, I	1
Bianchi, F	1
Gatt, M	1
Lanzoni, M	1
Lynch, C	1
Mokoroa, O	1
Nelen, V	1
Neville, A	1
O'Mahony, MT	1
Randrianaivo-Ranjatoelina, H	1
Rissmann, A	1
Tucker, D	1
de Walle, HEK	1
Zymak-Zakutnia, N	1
Rankin, J	1
Mir, A	1
Chaudhary, M	1
Alkhaldi, H	1
Alhazmi, R	1
Albaradie, R	1
Housawi, Y	1
Peng, BW	1
Liang, HC	1
Li, JL	1
Yang, SY	1
Liang, W	1
Zhang, FQ	1
Chen, WX	1
Kholin, AA	1
Bhat, RY	1
Kakkar, S	1
Prakashini, K	1
Trivisano, M	1
Specchio, N	1
Vigevano, F	1
Walker, V	1
Barragan-Martinez, D	1
Urbanos-Nunez, A	1
Martinez-Salio, A	1
Grande-Martín, A	1
Pardal-Fernández, JM	1
Carrascosa-Romero, MC	1
De Cabo, C	1
Hikita, T	2
Kodama, H	2
Nakamoto, N	2
Kaga, F	2
Amakata, K	2
Ogita, K	2
Kaneko, S	2
Fujii, Y	2
Yanagawa, Y	2
Kacalak-Rzepka, A	1
Kiedrowicz, M	1
Bielecka-Grzela, S	1
Ratajczak-Stefanska, V	1
Maleszka, R	1
Mikulska, D	1
Sabers, A	1
Larsen, K	1
Blichfeldt, S	1
Sahlholdt, L	1
Rasmussen, JO	1
Dowdell, KC	1
Pesnicak, L	1
Hoffmann, V	1
Steadman, K	1
Remaley, AT	1
Cohen, JI	1
Straus, SE	1
Rao, VK	1
García, C	1
Rubio, G	1
Thibert, RL	1
Conant, KD	1
Braun, EK	1
Bruno, P	1
Said, RR	1
Nespeca, MP	1
Thiele, EA	1
Ornoy, A	1
Vignoli, A	1
Canevini, MP	1
Darra, F	1
La Selva, L	1
Fiorini, E	1
Piazzini, A	1
Lazzarotto, F	1
Zucca, C	1
Dalla Bernardina, B	1
Al-Mendalawi, MD	1
Seidahmed, MZ	1
Hamed, SA	1
Albayrak, F	1
Cerrah, S	1
Albayrak, A	1
Dursun, H	1
Yildirim, R	1
Uyanik, A	1
Liukkonen, E	1
Kantola-Sorsa, E	1
Paetau, R	1
Gaily, E	1
Peltola, M	1
Granström, ML	1
Hakonen, AH	1
Isohanni, P	1
Rantamäki, M	1
Kälviäinen, R	1
Nordin, A	1
Uusimaa, J	1
Paetau, A	1
Udd, B	1
Pihko, H	1
Wartiovaara, A	1
Flesler, S	1
Sakr, D	1
Cersósimo, R	1
Caraballo, R	1
de las Heras, J	1
Garin, I	1
de Nanclares, GP	1
Aguayo, A	1
Rica, I	1
Castaño, L	1
Vela, A	1
Qureshi, AU	1
Abbas, R	1
Ahmad, TM	1
Cherian, A	1
Baheti, NN	1
Menon, RN	1
Iyer, RS	1
Rathore, C	1
Radhakrishnan, A	1
van Zoelen, MA	1
de Graaf, M	1
van Dijk, MR	1
Bogte, A	1
van Erpecum, KJ	1
Rockmann, H	1
Maarschalk-Ellerbroek, LJ	1
Yang, ZX	1
Liu, XY	1
Qin, J	1
Zhang, YH	1
Ermolenko, NA	1
Ermakov, AIu	1
Buchneva, IA	1
Zakharova, EI	1
Kalikina, TA	1
Azad, C	1
Guglani, V	1
Malm, H	1
Kajantie, E	1
Kivirikko, S	1
Kääriäinen, H	1
Peippo, M	1
Somer, M	2
Sakakihara, Y	1
Tanaka, M	2
Inoue, Y	2
Oguni, H	1
Takahashi, T	1
Adachi, M	2
Tsuneishi, S	1
Nakamura, H	1
Krsek, P	1
Sebronová, V	1
Procházka, T	1
Maulisová, A	1
Komárek, V	1
Bourgeois, BF	1
Wheless, JW	1
Hornby, SJ	1
Welham, RA	1
Donovan, SJ	1
Nunes, EV	1
Stewart, JW	1
Ross, D	1
Quitkin, FM	1
Jensen, PS	1
Klein, DF	1
Toomes, M	1
Maleck, WH	1
Koetter, KP	1
Petroianu, GA	1
Servillo, G	1
Striano, P	1
Striano, S	1
Tortora, F	1
Boccella, P	1
De Robertis, E	1
Rossano, F	1
Briganti, F	1
Tufano, R	1
Houge, G	1
Fiskerstrand, T	1
Øyen, N	1
Anoop, P	1
Sasidharan, CK	1
Taubøll, E	1
Gjerstad, L	1
Henriksen, T	1
Husby, H	1
Papp, Z	1
Török, L	1
Sinclair, DB	1
Berg, M	1
Breault, R	1
Schorry, EK	1
Oppenheimer, SG	1
Saal, HM	1
Nejad, AG	1
Toofani, K	1
de Oliveira, RS	1
Lajeunie, E	2
Arnaud, E	1
Greensmith, A	1
Renier, D	2
Cheung, E	1
Wong, V	1
Fung, CW	1
Kini, U	1
Adab, N	1
Vinten, J	1
Fryer, A	1
Clayton-Smith, J	1
Camfield, C	1
Camfield, P	1
Benbadis, SR	1
Parisi, P	1
Ferri, R	1
Pagani, J	1
Cecili, M	1
Montemitro, E	1
Villa, MP	1
Marill, KA	1
Ellinor, PT	1
Maekawa, M	1
Ohta, K	1
Katagiri, R	1
Ueta, E	1
Naruse, I	1
Kikumoto, K	1
Yoshinaga, H	1
Oka, M	1
Ito, M	1
Endoh, F	1
Akiyama, T	1
Ohtsuka, Y	1
Kulkarni, ML	1
Zaheeruddin, M	1
Shenoy, N	1
Vani, HN	1
Seitz, CS	1
Pfeuffer, P	1
Raith, P	1
Bröcker, EB	1
Trautmann, A	1
Kowalczyk, EE	1
Koszewicz, MA	1
Budrewicz, SP	1
Podemski, R	1
Słotwiński, K	1
Nanjiani, A	1
Hossain, A	1
Mahgoub, N	1
Kulkarni, S	1
Hegde, A	1
Shah, KN	1
Nicolai, J	1
Gunning, B	1
Leroy, PL	1
Ceulemans, B	1
Vles, JS	1
Yamamoto, H	1
Fukuda, M	1
Murakami, H	1
Kamiyama, N	1
Miyamoto, Y	1
Gálvez-Andres, A	1
Blasco-Fontecilla, H	1
González-Parra, S	1
Molina, JD	1
Padín, JM	1
Rodriguez, RH	1
Genton, P	1
Ferlazzo, E	1
Thomas, P	1
Shiga, K	1
Markakis, I	1
Alexiou, E	1
Xifaras, M	1
Gekas, G	1
Rombos, A	1
Nakazato, Y	1
Tamura, N	1
Shimazu, K	1
Meldrum, B	1
Werdan, K	1
Hannig, C	1
Bolte, HD	1
DiLiberti, JH	1
Farndon, PA	1
Dennis, NR	1
Curry, CJ	1
Spehlmann, R	1
Norcross, K	1
Rasmus, SC	1
Schlageter, NL	1
Boldyrev, AI	1
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el Sayed, F	1
Moreau-Cabarrot, A	1
Bazex, J	1
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Trial	Phase	Enrollment	Study Type	Start Date	Status
Pharmacotoxicology of Trichloroethylene Metabolites: Short-term Effect of DCA on in Vivo Tyrosine Catabolism and MAAI Expression[NCT00865514]		2 participants (Actual)	Interventional	2011-08-31	Terminated (stopped due to Difficulty in obtaining the solution from the compounding pharmacies caused a two year delay in start-up; the funding ended prior to study completion.)
Verapamil as Adjunctive Seizure Therapy for Children and Young Adults With Dravet Syndrome[NCT01607073]	Phase 2	2 participants (Actual)	Interventional	2012-04-30	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

The secondary outcome measure is the change in number of absence seizures from Week 8 (Baseline) to Week 12 (NCT01607073)
Timeframe: Week 8 to Week 12

Change in Number of General Tonic-clonic Seizures From Week 8 (Baseline) Visit to Week 12 Visit

Intervention	Abscence seizures (Number)
Week 8 Baseline	165
Week 12 Verapamil 4mg/kg/Day	101

The primary study endpoint is the change in number of seizures from baseline. Since we only had one participant finish the study, the endpoint was changed to Week 12 visit. Participants were on verapamil for 4 weeks at Week 12. (NCT01607073)
Timeframe: Week 8 (baseline) to Week 12

Change in Number of Myoclonic Seizures From Week 8 (Baseline) to Week 12

Intervention	General tonic-clonic seizures (Number)
Week 8 Baseline	39
Week 12 Verapamil 4mg/kg/Day	14

The secondary outcome is the change in number of myoclonic seizures between baseline Week 8 visit and Week 12 visit. (NCT01607073)
Timeframe: Week 8 (baseline) to Week 12

Article	Year
Post-hypoxic myoclonus; what we know and gaps in knowledge. Tropical doctor, 2023, Volume: 53, Issue:4 Topics: Cardiopulmonary Resuscitation; Clonazepam; Humans; Hypoxia; Myoclonus; Syndrome; Valproic Acid	2023
A potential cause of adolescent onset Dyke-Davidoff-Masson syndrome: A case report. Medicine, 2019, Volume: 98, Issue:51 Topics: Brain Diseases; Carbamazepine; China; Chronic Disease; Female; Humans; Intellectual Disability; Magn	2019
Epilepsy in patients with EAST syndrome caused by mutation in the KCNJ10. Brain & development, 2019, Volume: 41, Issue:8 Topics: Anticonvulsants; Brain; Carbamazepine; Cerebellar Ataxia; Child; Child, Preschool; Epilepsy; Female;	2019
Ammonia metabolism and hyperammonemic disorders. Advances in clinical chemistry, 2014, Volume: 67 Topics: Ammonia; Animals; Arginine; Biological Transport; Brain; Cell Membrane; Humans; Hyperammonemia; Hype	2014
Rowell's syndrome in the course of treatment with sodium valproate: a case report and review of the literature data. Clinical and experimental dermatology, 2009, Volume: 34, Issue:6 Topics: Antipsychotic Agents; Benzodiazepines; Depressive Disorder; Drug Therapy, Combination; Erythema Mult	2009
Valproic acid in pregnancy: how much are we endangering the embryo and fetus? Reproductive toxicology (Elmsford, N.Y.), 2009, Volume: 28, Issue:1 Topics: Abnormalities, Drug-Induced; Adolescent; Animals; Anticonvulsants; Autistic Disorder; Child; Child D	2009
A migraine variant with abdominal colic and Alice in Wonderland syndrome: a case report and review. BMC neurology, 2010, Jan-06, Volume: 10 Topics: Brain; Colic; Electroencephalography; Evoked Potentials; Hallucinations; Humans; Intestinal Diseases	2010
[Bening epilepsy of childhood with centrotemporal spikes]. Ryoikibetsu shokogun shirizu, 2002, Issue:37 Pt 6 Topics: Carbamazepine; Child; Child, Preschool; Diagnosis, Differential; Electroencephalography; Epilepsy, R	2002
[Epilepsy with GTCs on awakening]. Ryoikibetsu shokogun shirizu, 2002, Issue:37 Pt 6 Topics: Adolescent; Adult; Child; Diagnosis, Differential; Epilepsy, Tonic-Clonic; Humans; Phenobarbital; Pr	2002
[Other generalized epilepsies not defined above]. Ryoikibetsu shokogun shirizu, 2002, Issue:37 Pt 6 Topics: Diagnosis, Differential; Epilepsy, Generalized; Humans; Phenobarbital; Prognosis; Syndrome; Valproic	2002
[Epilepsy with myoclonic absences]. Ryoikibetsu shokogun shirizu, 2002, Issue:37 Pt 6 Topics: Child; Child, Preschool; Diagnosis, Differential; Drug Therapy, Combination; Electroencephalography;	2002
[Photosensitivity syndrome]. Ryoikibetsu shokogun shirizu, 2002, Issue:37 Pt 6 Topics: Color; Diagnosis, Differential; Epilepsy, Partial, Sensory; Eyeglasses; Humans; Light; Photic Stimul	2002
[Eyelid myoclonia with absences (EMA)]. Ryoikibetsu shokogun shirizu, 2002, Issue:37 Pt 6 Topics: Anticonvulsants; Child; Child, Preschool; Diagnosis, Differential; Electroencephalography; Epilepsie	2002
Chronic management of seizures in the syndromes of idiopathic generalized epilepsy. Epilepsia, 2003, Volume: 44 Suppl 2 Topics: Adult; Anticonvulsants; Child; Clinical Trials as Topic; Epilepsy, Generalized; Fructose; Humans; La	2003
Acute management of seizures in the syndromes of idiopathic generalized epilepsies. Epilepsia, 2003, Volume: 44 Suppl 2 Topics: Acute Disease; Adolescent; Adult; Anticonvulsants; Clonazepam; Comorbidity; Drug Administration Sche	2003
Management guidelines for children with idiopathic generalized epilepsy. Epilepsia, 2005, Volume: 46 Suppl 9 Topics: Adolescent; Anticonvulsants; Child; Electroencephalography; Epilepsy, Absence; Epilepsy, Generalized	2005
Practical management issues for idiopathic generalized epilepsies. Epilepsia, 2005, Volume: 46 Suppl 9 Topics: Age Factors; Age of Onset; Anticonvulsants; Electric Stimulation Therapy; Epilepsy, Generalized; Hum	2005
Pharmacology of GABA. Clinical neuropharmacology, 1982, Volume: 5, Issue:3 Topics: 4-Aminobutyrate Transaminase; Anxiety Disorders; Autonomic Nervous System; Barbiturates; Benzodiazep	1982
The absence epilepsies. Epilepsia, 1993, Volume: 34 Suppl 3 Topics: Adolescent; Adult; Age Factors; Aged; Child; Electroencephalography; Epilepsy, Absence; Female; Huma	1993
Susac syndrome. Medicine, 1998, Volume: 77, Issue:1 Topics: Adult; Anti-Inflammatory Agents; Audiometry, Pure-Tone; Brain Diseases; Cyclophosphamide; Diagnosis,	1998
[Fetal valproate syndrome]. Ryoikibetsu shokogun shirizu, 2000, Issue:30 Pt 5 Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anticonvulsants; Diagnosis, Differential; Fema	2000
Valproate hepatotoxicity syndrome: hypotheses of pathogenesis. Pharmaceutisch weekblad. Scientific edition, 1992, Jun-19, Volume: 14, Issue:3A Topics: Ammonia; Animals; Carnitine; Chemical and Drug Induced Liver Injury; Humans; Liver; Liver Diseases;	1992
Valproate and carbamazepine in the treatment of panic and posttraumatic stress disorders, withdrawal states, and behavioral dyscontrol syndromes. Journal of clinical psychopharmacology, 1992, Volume: 12, Issue:1 Suppl Topics: Carbamazepine; Humans; Mental Disorders; Panic Disorder; Stress Disorders, Post-Traumatic; Substance	1992
[The stiff-man syndrome]. Nihon rinsho. Japanese journal of clinical medicine, 1987, Volume: 45, Issue:2 Topics: Baclofen; Diazepam; Humans; Muscle Rigidity; Muscle Spasticity; Syndrome; Valproic Acid	1987
Verification of the fetal valproate syndrome phenotype. American journal of medical genetics, 1988, Volume: 29, Issue:1 Topics: Abnormalities, Drug-Induced; Facial Bones; Female; Growth Disorders; Humans; Infant; Infant, Newborn	1988

Article	Year
Effective prophylactic therapy for cyclic vomiting syndrome in children using valproate. Brain & development, 2009, Volume: 31, Issue:6 Topics: Anticonvulsants; Child; Child, Preschool; Dehydration; Dose-Response Relationship, Drug; Drug Admini	2009
[The enkorat treatment of infantile spasms and the Lennox-Gastaut syndrome]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 1994, Volume: 94, Issue:6 Topics: Anticonvulsants; Carbamazepine; Child, Preschool; Clonazepam; Drug Therapy, Combination; Epilepsy; E	1994
The efficacy of felbamate as add-on therapy to valproic acid in the Lennox-Gastaut syndrome. Epilepsy research, 1999, Volume: 34, Issue:2-3 Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Cross-Over Studies; Double-Blind Method; Drug	1999
[ESES-syndrome in child- and adolescent psychiatry]. Zeitschrift fur Kinder- und Jugendpsychiatrie und Psychotherapie, 2000, Volume: 28, Issue:1 Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Clobazam; Developmen	2000
Stiripentol in severe myoclonic epilepsy in infancy: a randomised placebo-controlled syndrome-dedicated trial. STICLO study group. Lancet (London, England), 2000, Nov-11, Volume: 356, Issue:9242 Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Child, Preschool; Clobazam; Dioxolanes; Doubl	2000
Valproic acid in Isaacs-Mertens syndrome. Clinical neuropharmacology, 1987, Volume: 10, Issue:3 Topics: Adolescent; Adult; Carbamazepine; Clinical Trials as Topic; Electromyography; Humans; Middle Aged; M	1987

Article	Year
Maternal Duplication 15q11-13 Syndrome with Autism Spectrum Disorder: Mood Stabilization by Carbamazepine. Journal of child and adolescent psychopharmacology, 2022, Volume: 32, Issue:2 Topics: Anticonvulsants; Antimanic Agents; Autism Spectrum Disorder; Benzodiazepines; Carbamazepine; Humans;	2022
A case of GFAP-IgG positivity followed by anti-NMDAR encephalitis. BMC pediatrics, 2022, 10-17, Volume: 22, Issue:1 Topics: Acyclovir; Anti-Inflammatory Agents; Anti-N-Methyl-D-Aspartate Receptor Encephalitis; Autoantibodies	2022
Posthypoxic action myoclonus (the Lance-Adams syndrome). BMJ case reports, 2020, Apr-16, Volume: 13, Issue:4 Topics: Heart Arrest; Humans; Hypoxia, Brain; Levetiracetam; Male; Middle Aged; Myoclonus; Syndrome; Valproi	2020
Early Lance-Adams syndrome after cardiac arrest: Prevalence, time to return to awareness, and outcome in a large cohort. Resuscitation, 2017, Volume: 115 Topics: Adult; Aged, 80 and over; Anticonvulsants; Cardiopulmonary Resuscitation; Clonazepam; Drug Combinati	2017
Fetal Valproate Syndrome - Still a Problem Today! Zeitschrift fur Geburtshilfe und Neonatologie, 2017, Volume: 221, Issue:5 Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Cesarean Section; Drug Therapy, Combination; Ep	2017
Fetal valproate syndrome: the Irish experience. Irish journal of medical science, 2018, Volume: 187, Issue:4 Topics: Abnormalities, Drug-Induced; Female; Humans; Ireland; Male; Pregnancy; Retrospective Studies; Syndro	2018
Prevalence of valproate syndrome in Europe from 2005 to 2014: A registry based multi-centre study. European journal of medical genetics, 2018, Volume: 61, Issue:9 Topics: Adult; Anticonvulsants; Cognitive Dysfunction; Congenital Abnormalities; Epilepsy; Europe; Female; H	2018
Acquired epileptiform opercular syndrome evaluated with real-time transcranial Doppler ultrasound-video-electroencephalogram before and after treatment: a case report. BMC neurology, 2019, Jul-17, Volume: 19, Issue:1 Topics: Anticonvulsants; Child, Preschool; Electroencephalography; Humans; Male; Methylprednisolone; Seizure	2019
[The syndrome of malignant migrating partial seizures in infancy or Coppola-Dulac syndrome (19 cases)]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2013, Volume: 113, Issue:3 Topics: Anticonvulsants; Disease Progression; Electroencephalography; Epilepsies, Partial; Female; Follow-Up	2013
Hemiconvulsion-hemiplegia-epilepsy syndrome: clinical course and neuroradiological features in a 20-month-old girl. BMJ case reports, 2014, Mar-10, Volume: 2014 Topics: Anticonvulsants; Atrophy; Brain; Carbamazepine; Epilepsy; Female; Hemiplegia; Humans; Infant; Syndro	2014
Extending the use of stiripentol to other epileptic syndromes: a case of PCDH19-related epilepsy. European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2015, Volume: 19, Issue:2 Topics: Age of Onset; Anticonvulsants; Autistic Disorder; Benzodiazepines; Cadherins; Child; Clobazam; Cogni	2015
[Red ear syndrome: a case report with good therapeutic response]. Revista de neurologia, 2015, Sep-01, Volume: 61, Issue:5 Topics: Adult; Ear Auricle; Ear Diseases; Female; Humans; Pain; Recurrence; Remission Induction; Syndrome; V	2015
Tonic Seizure Status Epilepticus Triggered by Valproate in a Child with Doose Syndrome. Neuropediatrics, 2016, Volume: 47, Issue:3 Topics: Anticonvulsants; Child; Electroencephalography; Epilepsies, Myoclonic; Humans; Male; Seizures; Statu	2016
[Valproate treatment during pregnancy: description of four cases with foetal valproate syndrome]. Ugeskrift for laeger, 2009, Jan-19, Volume: 171, Issue:4 Topics: Abnormalities, Drug-Induced; Anticonvulsants; Child; Child, Preschool; Developmental Disabilities; E	2009
Valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, diminishes lymphoproliferation in the Fas -deficient MRL/lpr(-/-) murine model of autoimmune lymphoproliferative syndrome (ALPS). Experimental hematology, 2009, Volume: 37, Issue:4 Topics: Animals; Apoptosis; Autoimmune Diseases; Cell Proliferation; Cells, Cultured; Disease Models, Animal	2009
Efficacy and safety of levetiracetam in the treatment of Panayiotopoulos syndrome. Epilepsy research, 2009, Volume: 85, Issue:2-3 Topics: Anticonvulsants; Child; Drug Therapy, Combination; Electroencephalography; Epilepsies, Partial; Fema	2009
Epilepsy in Angelman syndrome: a questionnaire-based assessment of the natural history and current treatment options. Epilepsia, 2009, Volume: 50, Issue:11 Topics: Adolescent; Adult; Angelman Syndrome; Anticonvulsants; Child; Child, Preschool; Clonazepam; Comorbid	2009
Ring chromosome 20 syndrome: a link between epilepsy onset and neuropsychological impairment in three children. Epilepsia, 2009, Volume: 50, Issue:11 Topics: Adult; Age of Onset; Anticonvulsants; Child; Chromosomes, Human, Pair 20; Cognition Disorders; Comor	2009
A case of fetal valproate syndrome with new features expanding the phenotype. Saudi medical journal, 2009, Volume: 30, Issue:7 Topics: Abnormalities, Multiple; Anticonvulsants; Epilepsy; Female; Fetus; Humans; Infant; Phenotype; Pregna	2009
DRESS syndrome with fatal results induced by sodium valproate in a patient with brucellosis and a positive cytoplasmic antineutrophilic cytoplasmic antibody test result. Rheumatology international, 2012, Volume: 32, Issue:7 Topics: Anti-Bacterial Agents; Antibodies, Antineutrophil Cytoplasmic; Anticonvulsants; Brucellosis; Drug Er	2012
Long-term outcome of 32 children with encephalopathy with status epilepticus during sleep, or ESES syndrome. Epilepsia, 2010, Volume: 51, Issue:10 Topics: Adolescent; Anticonvulsants; Child; Cognition Disorders; Drug Therapy, Combination; Electroencephalo	2010
[Mitochondrial recessive ataxia syndrome (MIRAS) and valproate toxicity]. Duodecim; laaketieteellinen aikakauskirja, 2010, Volume: 126, Issue:13 Topics: Anticonvulsants; Ataxia; DNA, Mitochondrial; Genes, Recessive; Humans; Liver Failure; Mutation; Synd	2010
Benign infantile focal epilepsy with midline spikes and waves during sleep: a new epileptic syndrome or a variant of benign focal epilepsy? Epileptic disorders : international epilepsy journal with videotape, 2010, Volume: 12, Issue:3 Topics: Age of Onset; Anticonvulsants; Carbamazepine; Child, Preschool; Drug Therapy, Combination; Electroen	2010
Familial hyperinsulinism-hyperammonemia syndrome in a family with seizures: case report. Journal of pediatric endocrinology & metabolism : JPEM, 2010, Volume: 23, Issue:8 Topics: Adult; Anticonvulsants; Child, Preschool; Congenital Hyperinsulinism; Family Health; Female; Glutama	2010
A case of polyglandular autoimmune syndrome type I with unusual presentation. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2011, Volume: 21, Issue:3 Topics: Alcaligenes faecalis; Anti-Bacterial Agents; Anti-Inflammatory Agents; Anticonvulsants; Antifungal A	2011
Atonic variant of benign childhood epilepsy with centrotemporal spikes (atonic-BECTS): a distinct electro-clinical syndrome. Brain & development, 2012, Volume: 34, Issue:6 Topics: Age of Onset; Anticonvulsants; Child, Preschool; Electroencephalography; Epilepsy, Generalized; Epil	2012
Valproic acid-induced DRESS syndrome with acute liver failure. The Netherlands journal of medicine, 2012, Volume: 70, Issue:3 Topics: Adult; Anticonvulsants; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Eosinophilia;	2012
[Clinical and electroencephalographic characteristics of Jeavons syndrome]. Zhonghua er ke za zhi = Chinese journal of pediatrics, 2012, Volume: 50, Issue:6 Topics: Adolescent; Age of Onset; Anticonvulsants; Child; Child, Preschool; Electroencephalography; Electrom	2012
[Epilepsies with electric status epilepticus in sleep: peculiarities of clinical course and rational approaches to treatment]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2011, Volume: 111, Issue:5 Pt 2 Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Resistance; Electricity; E	2011
Eyelid myoclonia with absence seizure precipitated by carbamazepine therapy. Indian pediatrics, 2012, Volume: 49, Issue:10 Topics: Carbamazepine; Child; Clonazepam; Epilepsy, Absence; Female; Humans; Myoclonus; Syndrome; Valproic A	2012
Valproate embryopathy in three sets of siblings: further proof of hereditary susceptibility. Neurology, 2002, Aug-27, Volume: 59, Issue:4 Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Child; Child, Preschool; Developmental Disabil	2002
Successful treatment of Ohtahara syndrome with chloral hydrate. Pediatric neurology, 2002, Volume: 27, Issue:5 Topics: Anticonvulsants; Chloral Hydrate; Drug Therapy, Combination; Electroencephalography; Female; Humans;	2002
Congenital nasolacrimal duct obstruction requiring external dacryocystorhinostomies in a child with foetal valproate syndrome. Eye (London, England), 2003, Volume: 17, Issue:4 Topics: Abnormalities, Drug-Induced; Anticonvulsants; Dacryocystorhinostomy; Female; Humans; Infant; Lacrima	2003
"Outer-directed irritability": a distinct mood syndrome in explosive youth with a disruptive behavior disorder? The Journal of clinical psychiatry, 2003, Volume: 64, Issue:6 Topics: Adolescent; Adult; Age Factors; Aggression; Anticonvulsants; Attention Deficit and Disruptive Behavi	2003
Out-of-hospital management of benzodiazepine-resistant status epilepticus in a child with Wolf-Hirschhorn syndrome. Epileptic disorders : international epilepsy journal with videotape, 2003, Volume: 5, Issue:2 Topics: Abnormalities, Multiple; Anticonvulsants; Apnea; Child; Chromosome Deletion; Chromosomes, Human, Pai	2003
Posterior reversible encephalopathy syndrome (PRES) in critically ill obstetric patients. Intensive care medicine, 2003, Volume: 29, Issue:12 Topics: Adult; Fatal Outcome; Female; Humans; Magnetic Resonance Imaging; Nervous System Diseases; Postpartu	2003
[Fetal valproate syndrome]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2003, Aug-28, Volume: 123, Issue:16 Topics: Anticonvulsants; Epilepsy; Female; Humans; Maternal-Fetal Exchange; Pregnancy; Pregnancy Complicatio	2003
Patent ductus arteriosus in fetal valproate syndrome. Indian journal of pediatrics, 2003, Volume: 70, Issue:8 Topics: Abnormalities, Drug-Induced; Adult; Arm; Ductus Arteriosus, Patent; Female; Head; Humans; Infant, Ne	2003
[Fetal valproate syndrome]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2003, Oct-09, Volume: 123, Issue:19 Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Maternal-Fetal Exchange; Pre	2003
[Anticonvulsant hypersensitivity syndrome]. Orvosi hetilap, 2004, Aug-08, Volume: 145, Issue:32 Topics: Acetates; Amines; Anticonvulsants; Carbamazepine; Cyclohexanecarboxylic Acids; Drug Eruptions; Drug	2004
Valproic acid-induced pancreatitis in childhood epilepsy: case series and review. Journal of child neurology, 2004, Volume: 19, Issue:7 Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Diagnosis, Differential; Dose-Response Relatio	2004
Valproate embryopathy: clinical and cognitive profile in 5 siblings. American journal of medical genetics. Part A, 2005, Mar-01, Volume: 133A, Issue:2 Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anticonvulsants; Child; Child Behavior; Child,	2005
Co-existence of lycanthropy and Cotard's syndrome in a single case. Acta psychiatrica Scandinavica, 2005, Volume: 111, Issue:3 Topics: Adult; Antipsychotic Agents; Bipolar Disorder; Combined Modality Therapy; Diagnostic and Statistical	2005
Baller-Gerold syndrome after fetal exposure to sodium valproate. American journal of medical genetics. Part A, 2005, Apr-01, Volume: 134A, Issue:1 Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Anticonvulsants; Craniosynostoses; Female; Hum	2005
Topiramate-valproate-induced hyperammonemic encephalopathy syndrome: case report. Journal of child neurology, 2005, Volume: 20, Issue:2 Topics: Adolescent; Anticonvulsants; Brain Diseases; Chromosome Inversion; Chromosomes, Human, Pair 15; Drug	2005
Dysmorphic features: an important clue to the diagnosis and severity of fetal anticonvulsant syndromes. Archives of disease in childhood. Fetal and neonatal edition, 2006, Volume: 91, Issue:2 Topics: Abnormalities, Drug-Induced; Adolescent; Anthropometry; Anticonvulsants; Carbamazepine; Child; Child	2006
Ictal video-polysomnography and EEG spectral analysis in a child with severe Panayiotopoulos syndrome. Epileptic disorders : international epilepsy journal with videotape, 2005, Volume: 7, Issue:4 Topics: Anticonvulsants; Child; Electroencephalography; Epilepsies, Partial; Eye Movements; Hallucinations;	2005
Case records of the Massachusetts General Hospital. Case 37-2005. A 35-year-old man with cardiac arrest while sleeping. The New England journal of medicine, 2005, Dec-08, Volume: 353, Issue:23 Topics: Adult; Bundle-Branch Block; Death, Sudden, Cardiac; Diagnosis, Differential; Electrocardiography; Fa	2005
Exencephaly induction by valproic acid in the genetic polydactyly/arhinencephaly mouse, Pdn/Pdn. Congenital anomalies, 2005, Volume: 45, Issue:4 Topics: Abnormalities, Multiple; Animals; Craniofacial Abnormalities; Down-Regulation; Fibroblast Growth Fac	2005
EEG and seizure exacerbation induced by carbamazepine in Panayiotopoulos syndrome. Epileptic disorders : international epilepsy journal with videotape, 2006, Volume: 8, Issue:1 Topics: Anticonvulsants; Carbamazepine; Child, Preschool; Electroencephalography; Epilepsies, Partial; Human	2006
Fetal valproate syndrome. Indian journal of pediatrics, 2006, Volume: 73, Issue:10 Topics: Anticonvulsants; Child, Preschool; Female; Humans; Infant, Newborn; Infant, Newborn, Diseases; Male;	2006
Anticonvulsant hypersensitivity syndrome: cross-reactivity with tricyclic antidepressant agents. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2006, Volume: 97, Issue:5 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amines; Amitriptyline; Anticonvulsants; Antidepressive A	2006
[Lance-Adams syndrome in patient with anoxic encephalopathy in the course of bronchial asthma]. Wiadomosci lekarskie (Warsaw, Poland : 1960), 2006, Volume: 59, Issue:7-8 Topics: Adult; Asthma; Cardiopulmonary Resuscitation; Diagnosis, Differential; Electroencephalography; Femal	2006
Patau syndrome. The Journal of neuropsychiatry and clinical neurosciences, 2007,Spring, Volume: 19, Issue:2 Topics: Abnormalities, Multiple; Antipsychotic Agents; Chromosomes, Human, Pair 13; Delusions; Face; Female;	2007
Hemifacial seizures and cerebellar tumor: a rare co-existence. Indian pediatrics, 2007, Volume: 44, Issue:5 Topics: Anticonvulsants; Benzodiazepines; Cerebellar Neoplasms; Child, Preschool; Clobazam; Comorbidity; Gan	2007
Acute hepatic injury in four children with Dravet syndrome: valproic acid, topiramate or acetaminophen? Seizure, 2008, Volume: 17, Issue:1 Topics: Acetaminophen; Analgesics, Non-Narcotic; Anticonvulsants; Chemical and Drug Induced Liver Injury; De	2008
A case of Pallister-Killian syndrome associated with West syndrome. Pediatric neurology, 2007, Volume: 37, Issue:3 Topics: Anticonvulsants; Humans; Infant; Isochromosomes; Male; Mosaicism; Pyridoxal Phosphate; Spasms, Infan	2007
Secondary bipolar disorder and Diogenes syndrome in frontotemporal dementia: behavioral improvement with quetiapine and sodium valproate. Journal of clinical psychopharmacology, 2007, Volume: 27, Issue:6 Topics: Antipsychotic Agents; Behavioral Symptoms; Bipolar Disorder; Dementia; Dibenzothiazepines; Female; H	2007
Absence status epilepsy: delineation of a distinct idiopathic generalized epilepsy syndrome. Epilepsia, 2008, Volume: 49, Issue:4 Topics: Adolescent; Adult; Age Factors; Age of Onset; Aged; Anticonvulsants; Benzodiazepines; Child; Comorbi	2008
[Valproate sodium is effective as prophylactic therapy for cyclic vomiting syndrome in a case]. No to hattatsu = Brain and development, 2008, Volume: 40, Issue:2 Topics: Adolescent; Child; Child, Preschool; Humans; Infant; Male; Syndrome; Valproic Acid; Vomiting	2008
Opsoclonus-myoclonus-ataxia syndrome with autoantibodies to glutamic acid decarboxylase. Clinical neurology and neurosurgery, 2008, Volume: 110, Issue:6 Topics: Adult; Anti-Inflammatory Agents; Anticonvulsants; Autoantibodies; Autoimmune Diseases; Female; Gait	2008
An adult case of cyclic vomiting syndrome successfully responding to valproic acid. Journal of neurology, 2008, Volume: 255, Issue:6 Topics: Anti-Anxiety Agents; Anticonvulsants; Antiemetics; Consciousness Disorders; Diazepam; Female; Humans	2008
[64-year-old patient with a long-term cramp syndrome]. Der Internist, 1984, Volume: 25, Issue:3 Topics: Chronic Disease; Electromyography; Humans; Male; Middle Aged; Muscle Cramp; Syndrome; Valproic Acid	1984
The fetal valproate syndrome. American journal of medical genetics, 1984, Volume: 19, Issue:3 Topics: Epilepsy; Face; Female; Heart Defects, Congenital; Humans; Infant, Low Birth Weight; Infant, Newborn	1984
Improvement of stiff-man syndrome with sodium valproate. Neurology, 1981, Volume: 31, Issue:9 Topics: Humans; Male; Middle Aged; Muscle Rigidity; Syndrome; Valproic Acid	1981
[Clinical evaluation of certain modern antiepileptic preparations]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1982, Volume: 82, Issue:6 Topics: Anticonvulsants; Automatism; Carbamazepine; Child; Clonazepam; Diencephalon; Epilepsy; Epilepsy, Abs	1982
[A case for diagnosis: syndrome of hypersensitivity to carbamazepine]. Annales de dermatologie et de venereologie, 1995, Volume: 122, Issue:3 Topics: Adult; Anticonvulsants; Carbamazepine; Drug Eruptions; Drug Hypersensitivity; Female; Humans; Skin T	1995
Fetal valproate syndrome: clinical and neuro-developmental features in two sibling pairs. Developmental medicine and child neurology, 1994, Volume: 36, Issue:4 Topics: Adult; Autistic Disorder; Child, Preschool; Clonazepam; Developmental Disabilities; Epilepsy; Family	1994
Omphalocele in a newborn baby exposed to sodium valproate in utero. European journal of pediatrics, 1995, Volume: 154, Issue:3 Topics: Face; Female; Hernia, Umbilical; Humans; Infant, Newborn; Male; Pregnancy; Prenatal Diagnosis; Prena	1995
[Drug hypersensitivity syndrome during treatment with valproic acid]. Presse medicale (Paris, France : 1983), 1995, Nov-11, Volume: 24, Issue:34 Topics: Adult; Anticonvulsants; Drug Hypersensitivity; Female; Humans; Syndrome; Valproic Acid	1995
[Embryofetopathy due to valproate: a pathology only little known. Apropos of 4 cases]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 1996, Volume: 3, Issue:9 Topics: Abnormalities, Drug-Induced; Anticonvulsants; Child, Preschool; Cleft Lip; Epilepsy; Face; Female; F	1996
Anterior uveitis and the anticonvulsant hypersensitivity syndrome. Archives of internal medicine, 1998, Jan-26, Volume: 158, Issue:2 Topics: Anticonvulsants; Carbamazepine; Drug Hypersensitivity; Humans; Male; Middle Aged; Syndrome; Uveitis,	1998
Syndromal and nonsyndromal primary trigonocephaly: analysis of a series of 237 patients. American journal of medical genetics, 1998, Jan-13, Volume: 75, Issue:2 Topics: Birth Weight; Child; Child, Preschool; Chromosome Aberrations; Chromosome Disorders; Craniosynostose	1998
Changes of the EEG paroxysmal pattern during felbamate therapy in Lennox-Gastaut syndrome: a case report. The International journal of neuroscience, 1998, Volume: 95, Issue:3-4 Topics: Adult; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Carbamazepine; Clobazam; Drug Therapy,	1998
[Effectiveness of valproic acid for postanoxic action myoclonus (Lance-Adams syndrome)]. Annales francaises d'anesthesie et de reanimation, 1998, Volume: 17, Issue:10 Topics: Adult; Anticonvulsants; Benzodiazepines; Humans; Hypoxia, Brain; Male; Myoclonus; Syndrome; Valproic	1998
Periodic discharge of adrenocorticotropin and vasopressin associated with focal glomerulosclerosis. Acta paediatrica Japonica : Overseas edition, 1998, Volume: 40, Issue:6 Topics: Adrenocorticotropic Hormone; Child; Glomerulosclerosis, Focal Segmental; Humans; Kidney Failure, Chr	1998
Anomalous right pulmonary artery origins in association with the fetal valproate syndrome. Journal of medical genetics, 1999, Volume: 36, Issue:1 Topics: Abnormalities, Drug-Induced; Anticonvulsants; Child, Preschool; Female; Humans; Infant; Male; Pregna	1999
Primary ciliary dyskinesia syndrome and primary generalised epilepsy. Scottish medical journal, 1999, Volume: 44, Issue:3 Topics: Adult; Anticonvulsants; Child; Child, Preschool; Ciliary Motility Disorders; Electroencephalography;	1999
Hypersensitivity syndrome due to 2 anticonvulsant drugs. Contact dermatitis, 1999, Volume: 41, Issue:3 Topics: Antibodies, Viral; Anticonvulsants; Child; Drug Hypersensitivity; Ethosuximide; Herpesvirus 6, Human	1999
[A case of fetal valproate syndrome with intractable wheezing due to submucosal tumor below the vocal cord]. No to hattatsu = Brain and development, 1999, Volume: 31, Issue:6 Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Fatal Outcome; Female; Humans; Infant; Infant,	1999
Treatment of Charles Bonnet syndrome with valproate. International clinical psychopharmacology, 2000, Volume: 15, Issue:2 Topics: Age Factors; Aged; Antimanic Agents; Female; Hallucinations; Humans; Syndrome; Treatment Outcome; Va	2000
A clinical study of 57 children with fetal anticonvulsant syndromes. Journal of medical genetics, 2000, Volume: 37, Issue:7 Topics: Abnormalities, Drug-Induced; Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Ep	2000
Fetal valproate syndrome and autism: additional evidence of an association. Developmental medicine and child neurology, 2001, Volume: 43, Issue:3 Topics: Autistic Disorder; Child; Child, Preschool; Developmental Disabilities; Epilepsy; Female; Follow-Up	2001
Reduced corneal sensation and severe dry eyes in a child with fetal valproate syndrome. Eye (London, England), 2001, Volume: 15, Issue:Pt 5 Topics: Anticonvulsants; Corneal Diseases; Female; Humans; Hypesthesia; Infant, Newborn; Pregnancy; Prenatal	2001
[Manic syndrome: diagnostic trends and principles of treatment]. La Revue du praticien, 1998, Apr-01, Volume: 48, Issue:7 Topics: Adult; Anticonvulsants; Antimanic Agents; Antipsychotic Agents; Bipolar Disorder; Carbamazepine; Chl	1998
'Foetal valproate syndrome and autism: additional evidence of an association'. Developmental medicine and child neurology, 2001, Volume: 43, Issue:12 Topics: Abnormalities, Drug-Induced; Autistic Disorder; Child; Epilepsy, Generalized; Female; Humans; Male;	2001
Ophthalmic findings in fetal anticonvulsant syndrome(s). Ophthalmology, 2002, Volume: 109, Issue:5 Topics: Abnormalities, Drug-Induced; Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Ep	2002
Preaxial polydactyly in the fetal valproate syndrome. European journal of pediatrics, 1992, Volume: 151, Issue:12 Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Face; Female; Fingers; Humans; Infant, Newborn	1992
Terminal deletion of chromosome 4p (4p16.3) shows a breakpoint between loci linked to Huntington disease. American journal of medical genetics, 1992, Jul-01, Volume: 43, Issue:4 Topics: Abnormalities, Multiple; Adolescent; Chromosome Banding; Chromosome Deletion; Chromosomes, Human, Pa	1992
Antiepileptics and the development of congenital anomalies. Neurology, 1992, Volume: 42, Issue:4 Suppl 5 Topics: Abnormalities, Drug-Induced; Anticonvulsants; Apgar Score; Birth Weight; Carbamazepine; Epilepsy; Fe	1992
[Valproic acid in the management of Sydenham's chorea]. Boletin medico del Hospital Infantil de Mexico, 1991, Volume: 48, Issue:4 Topics: Child; Chorea; Female; Humans; Syndrome; Valproic Acid	1991
[The first case of a child born with fetal valproic acid syndrome in Hungary]. Orvosi hetilap, 1989, Jan-29, Volume: 130, Issue:5 Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Infant, Newborn; Maternal-Fe	1989
Fetal valproate syndrome. American journal of medical genetics, 1986, Volume: 24, Issue:2 Topics: Abnormalities, Drug-Induced; Face; Humans; Syndrome; Valproic Acid	1986
Status epilepticus within the Lennox-Gastaut syndrome: clinical characteristics and management. Clinical EEG (electroencephalography), 1987, Volume: 18, Issue:2 Topics: Child; Clonazepam; Electroencephalography; Epilepsy; Humans; Male; Status Epilepticus; Syndrome; Val	1987
Prognosis in fetal valproate syndrome. The Journal of pediatrics, 1987, Volume: 111, Issue:2 Topics: Behavior; Child, Preschool; Female; Growth Disorders; Humans; Pregnancy; Prenatal Exposure Delayed E	1987
The fetal valproate syndrome. American journal of medical genetics, 1988, Volume: 31, Issue:2 Topics: Abnormalities, Drug-Induced; Anticonvulsants; Female; Fetus; Humans; Infant, Newborn; Pregnancy; Syn	1988
Progressive myoclonic epilepsy. The response to sodium di -- n -- propylacetate. Proceedings of the Australian Association of Neurologists, 1974, Volume: 11 Topics: Adult; Epilepsy; Humans; Male; Myoclonus; Syndrome; Valerates; Valproic Acid	1974

valproic acid and Syndrome