valproic acid has been researched along with Supranuclear Palsy, Progressive in 1 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Supranuclear Palsy, Progressive: A degenerative disease of the central nervous system characterized by balance difficulties; OCULAR MOTILITY DISORDERS (supranuclear ophthalmoplegia); DYSARTHRIA; swallowing difficulties; and axial DYSTONIA. Onset is usually in the fifth decade and disease progression occurs over several years. Pathologic findings include neurofibrillary degeneration and neuronal loss in the dorsal MESENCEPHALON; SUBTHALAMIC NUCLEUS; RED NUCLEUS; pallidum; dentate nucleus; and vestibular nuclei. (From Adams et al., Principles of Neurology, 6th ed, pp1076-7)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Leclair-Visonneau, L | 1 |
| Rouaud, T | 1 |
| Debilly, B | 1 |
| Durif, F | 1 |
| Houeto, JL | 1 |
| Kreisler, A | 1 |
| Defebvre, L | 1 |
| Lamy, E | 1 |
| Volteau, C | 1 |
| Nguyen, JM | 1 |
| Dily, SL | 1 |
| Damier, P | 1 |
| Boutoleau-Bretonnière, C | 1 |
| Lejeune, P | 1 |
| Derkinderen, P | 1 |
1 trial available for valproic acid and Supranuclear Palsy, Progressive
| Article | Year |
|---|---|
Randomized placebo-controlled trial of sodium valproate in progressive supranuclear palsy.
Topics: Aged; Double-Blind Method; Enzyme Inhibitors; Female; Humans; Male; Middle Aged; Supranuclear Palsy, | 2016 |