valproic acid has been researched along with Subarachnoid Hemorrhage in 12 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Subarachnoid Hemorrhage: Bleeding into the intracranial or spinal SUBARACHNOID SPACE, most resulting from INTRACRANIAL ANEURYSM rupture. It can occur after traumatic injuries (SUBARACHNOID HEMORRHAGE, TRAUMATIC). Clinical features include HEADACHE; NAUSEA; VOMITING, nuchal rigidity, variable neurological deficits and reduced mental status.
| Excerpt | Relevance | Reference |
|---|---|---|
| " He had been obese, had been receiving a standard dose of valproic acid since clipping surgery for subarachnoid hemorrhage 17 years previously, and had not consumed any alcohol since the surgery." | 7.73 | Hepatocellular carcinoma and nonalcoholic steatohepatitis developing during long-term administration of valproic acid. ( Iizuka, H; Katsuda, S; Okamoto, K; Sato, K; Ueda, Y; Ueno, K, 2005) |
| "Valproic acid (VPA) has shown potent anti-inflammatory effect and attenuates acute lung injury." | 5.48 | Valproic acid attenuates the risk of acute respiratory failure in patients with subarachnoid hemorrhage. ( Chien, WC; Chu, SJ; Chung, CH; Chung, TT; Liao, WI; Tsai, SH; Wang, JC, 2018) |
| " Plasma concentrations (pc), interactions between drugs in the ICU context, adverse effects and seizure occurrences were observed and recorded." | 5.37 | Levetiracetam compared to valproic acid: plasma concentration levels, adverse effects and interactions in aneurysmal subarachnoid hemorrhage. ( Bjeljac, M; Keller, E; Mink, S; Muroi, C; Seule, M, 2011) |
| "Its appearance on CT resembles subarachnoid hemorrhage despite the absence of subarachnoid blood." | 5.37 | Image in toxicology: Pseudo-subarachnoid hemorrhage in a case of severe valproic acid poisoning. ( Min, YG; Tse, ML, 2011) |
| " He had been obese, had been receiving a standard dose of valproic acid since clipping surgery for subarachnoid hemorrhage 17 years previously, and had not consumed any alcohol since the surgery." | 3.73 | Hepatocellular carcinoma and nonalcoholic steatohepatitis developing during long-term administration of valproic acid. ( Iizuka, H; Katsuda, S; Okamoto, K; Sato, K; Ueda, Y; Ueno, K, 2005) |
| "Seizures are a common complication that leads to neurological deficits and affects outcomes after aneurysmal subarachnoid haemorrhage (aSAH)." | 3.11 | Seizure prophylaxis following aneurysmal subarachnoid haemorrhage (SPSAH): study protocol for a multicentre randomised placebo-controlled trial of short-term sodium valproate prophylaxis in patients with acute subarachnoid haemorrhage. ( Chen, Y; Fang, M; Hu, X; Li, Y; Pang, B; Sun, B; Wu, H; Wu, P; Wu, Q; Xie, Z; Xu, S; You, C; Zhang, J; Zheng, N, 2022) |
| "Seizures and intracranial hemorrhage are possible medical diseases that any obstetrician may encounter." | 2.49 | Seizures and intracranial hemorrhage. ( Alexander, JM; Wilson, KL, 2013) |
| "Valproic acid (VPA) has shown potent anti-inflammatory effect and attenuates acute lung injury." | 1.48 | Valproic acid attenuates the risk of acute respiratory failure in patients with subarachnoid hemorrhage. ( Chien, WC; Chu, SJ; Chung, CH; Chung, TT; Liao, WI; Tsai, SH; Wang, JC, 2018) |
| " Plasma concentrations (pc), interactions between drugs in the ICU context, adverse effects and seizure occurrences were observed and recorded." | 1.37 | Levetiracetam compared to valproic acid: plasma concentration levels, adverse effects and interactions in aneurysmal subarachnoid hemorrhage. ( Bjeljac, M; Keller, E; Mink, S; Muroi, C; Seule, M, 2011) |
| "Its appearance on CT resembles subarachnoid hemorrhage despite the absence of subarachnoid blood." | 1.37 | Image in toxicology: Pseudo-subarachnoid hemorrhage in a case of severe valproic acid poisoning. ( Min, YG; Tse, ML, 2011) |
| "Zonisamide was changed to sodium valproate." | 1.31 | Smoldering myeloma associated with zonisamide treatment. ( Ando, Y; Asai, S; Hotta, T; Kobayashi, H; Miyachi, H, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (25.00) | 29.6817 |
| 2010's | 7 (58.33) | 24.3611 |
| 2020's | 2 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, Y | 1 |
| Fang, M | 1 |
| Wu, P | 1 |
| Xie, Z | 1 |
| Wu, H | 1 |
| Wu, Q | 1 |
| Xu, S | 1 |
| Li, Y | 1 |
| Sun, B | 1 |
| Pang, B | 1 |
| Zheng, N | 1 |
| Zhang, J | 1 |
| Hu, X | 1 |
| You, C | 1 |
| Wu, CH | 1 |
| Tsai, YC | 1 |
| Tsai, TH | 1 |
| Kuo, KL | 1 |
| Su, YF | 1 |
| Chang, CH | 1 |
| Lin, CL | 1 |
| Liao, WI | 1 |
| Chien, WC | 1 |
| Chung, CH | 1 |
| Wang, JC | 1 |
| Chung, TT | 1 |
| Chu, SJ | 1 |
| Tsai, SH | 1 |
| Wilson, KL | 1 |
| Alexander, JM | 1 |
| Tso, MK | 1 |
| Lass, E | 1 |
| Ai, J | 1 |
| Loch Macdonald, R | 1 |
| Hamming, AM | 1 |
| van der Toorn, A | 1 |
| Rudrapatna, US | 1 |
| Ma, L | 1 |
| van Os, HJ | 1 |
| Ferrari, MD | 1 |
| van den Maagdenberg, AM | 1 |
| van Zwet, E | 1 |
| Poinsatte, K | 1 |
| Stowe, AM | 1 |
| Dijkhuizen, RM | 1 |
| Wermer, MJ | 1 |
| Mink, S | 1 |
| Muroi, C | 1 |
| Seule, M | 1 |
| Bjeljac, M | 1 |
| Keller, E | 1 |
| Min, YG | 1 |
| Tse, ML | 1 |
| Senthilkumaran, S | 1 |
| Balamurugan, N | 1 |
| Menezes, RG | 1 |
| Thirumalaikolundusubramanian, P | 1 |
| Sato, K | 1 |
| Ueda, Y | 1 |
| Ueno, K | 1 |
| Okamoto, K | 1 |
| Iizuka, H | 1 |
| Katsuda, S | 1 |
| Wong, GK | 1 |
| Poon, WS | 1 |
| Asai, S | 1 |
| Miyachi, H | 1 |
| Kobayashi, H | 1 |
| Hotta, T | 1 |
| Ando, Y | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pilot Study of Seizure Prophylaxis With Levetiracetam in Aneurysmal Subarachnoid Hemorrhage[NCT01935908] | Phase 4 | 0 participants (Actual) | Interventional | 2013-05-31 | Withdrawn (stopped due to no funding) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for valproic acid and Subarachnoid Hemorrhage
| Article | Year |
|---|---|
Seizures and intracranial hemorrhage.
Topics: Anticonvulsants; Carbamazepine; Congenital Abnormalities; Eclampsia; Epilepsy; Female; Folic Acid; H | 2013 |
1 trial available for valproic acid and Subarachnoid Hemorrhage
| Article | Year |
|---|---|
Seizure prophylaxis following aneurysmal subarachnoid haemorrhage (SPSAH): study protocol for a multicentre randomised placebo-controlled trial of short-term sodium valproate prophylaxis in patients with acute subarachnoid haemorrhage.
Topics: Aneurysm, Ruptured; Humans; Multicenter Studies as Topic; Randomized Controlled Trials as Topic; Sei | 2022 |
10 other studies available for valproic acid and Subarachnoid Hemorrhage
| Article | Year |
|---|---|
Valproic Acid Reduces Vasospasm through Modulation of Akt Phosphorylation and Attenuates Neuronal Apoptosis in Subarachnoid Hemorrhage Rats.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Gene Expression Regulation; Humans; Neuro | 2021 |
Valproic acid attenuates the risk of acute respiratory failure in patients with subarachnoid hemorrhage.
Topics: Acute Disease; Adult; Aged; Anti-Inflammatory Agents; Databases, Factual; Female; Humans; Incidence; | 2018 |
Valproic Acid treatment after experimental subarachnoid hemorrhage.
Topics: Animals; Anticonvulsants; Cerebrovascular Circulation; Disease Models, Animal; Male; Mice, Inbred C5 | 2015 |
Valproate Reduces Delayed Brain Injury in a Rat Model of Subarachnoid Hemorrhage.
Topics: Animals; Brain Injuries; Disease Models, Animal; Male; Rats; Rats, Wistar; Subarachnoid Hemorrhage; | 2017 |
Levetiracetam compared to valproic acid: plasma concentration levels, adverse effects and interactions in aneurysmal subarachnoid hemorrhage.
Topics: Administration, Oral; Aged; Aneurysm, Ruptured; Anti-Bacterial Agents; Anticonvulsants; Biological A | 2011 |
Image in toxicology: Pseudo-subarachnoid hemorrhage in a case of severe valproic acid poisoning.
Topics: Anticonvulsants; Brain Edema; Drug Overdose; False Positive Reactions; Humans; Male; Predictive Valu | 2011 |
Role of Hounsfield units to distinguish pseudo-subarachnoid hemorrhage.
Topics: Anticonvulsants; Brain Edema; Drug Overdose; Humans; Subarachnoid Hemorrhage; Time Factors; Valproic | 2011 |
Hepatocellular carcinoma and nonalcoholic steatohepatitis developing during long-term administration of valproic acid.
Topics: Anticonvulsants; Carcinoma, Hepatocellular; Fatty Liver; Hepatitis; Humans; Liver Neoplasms; Male; M | 2005 |
Use of phenytoin and other anticonvulsant prophylaxis in patients with aneurysmal subarachnoid hemorrhage.
Topics: Cognition Disorders; Drug Interactions; Humans; Intracranial Aneurysm; Nimodipine; Phenytoin; Seizur | 2005 |
Smoldering myeloma associated with zonisamide treatment.
Topics: Adult; Agammaglobulinemia; Anticonvulsants; Epilepsy, Generalized; Humans; Immunoglobulin lambda-Cha | 2002 |