valproic acid has been researched along with Stress Disorders, Post-Traumatic in 23 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Stress Disorders, Post-Traumatic: A class of traumatic stress disorders with symptoms that last more than one month.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A number of preclinical studies and preliminary clinical reports, in some cases augmented by controlled studies, suggest that valproate and carbamazepine may have therapeutic effects in the treatment of certain anxiety disorders (panic disorder, post-traumatic stress disorder), alcohol and sedative-hypnotic withdrawal states, and behavioral dyscontrol syndromes." | 8.78 | Valproate and carbamazepine in the treatment of panic and posttraumatic stress disorders, withdrawal states, and behavioral dyscontrol syndromes. ( Friedman, LM; Keck, PE; McElroy, SL, 1992) |
| "It has been suggested that the anticonvulsant drug pregabalin may be useful in some anxiety disorders." | 5.19 | Effect of pregabalin augmentation in treatment of patients with combat-related chronic posttraumatic stress disorder: a randomized controlled trial. ( Baniasadi, M; Fayyazi Bordbar, MR; Hosseini, G; Mostafavi Toroghi, H; Rezaei Ardani, A, 2014) |
| "A number of preclinical studies and preliminary clinical reports, in some cases augmented by controlled studies, suggest that valproate and carbamazepine may have therapeutic effects in the treatment of certain anxiety disorders (panic disorder, post-traumatic stress disorder), alcohol and sedative-hypnotic withdrawal states, and behavioral dyscontrol syndromes." | 4.78 | Valproate and carbamazepine in the treatment of panic and posttraumatic stress disorders, withdrawal states, and behavioral dyscontrol syndromes. ( Friedman, LM; Keck, PE; McElroy, SL, 1992) |
| "Posttraumatic stress disorder (PTSD) is one of the chronic and disabling psychiatric disorders, particularly in combat veterans." | 2.84 | Effect of Rivastigmine Augmentation in Treatment of Male Patients With Combat-Related Chronic Posttraumatic Stress Disorder: A Randomized Controlled Trial. ( Fayyazi Bordbar, MR; Hosseini, G; Mostafavi Toroghi, H; Rezaei Ardani, A; Talaei, A, 2017) |
| "Twelve had PTSD." | 2.73 | Divalproex sodium for the treatment of PTSD and conduct disordered youth: a pilot randomized controlled clinical trial. ( Carrion, V; Chang, K; Khanzode, LA; Saxena, KS; Silverman, M; Steiner, H, 2007) |
| "Posttraumatic stress disorder (PTSD) is characterized by intrusive, avoidance, and hyperarousal symptoms." | 2.69 | Divalproex in posttraumatic stress disorder: an open-label clinical trial. ( Calais, LA; Cañive, JM; Clark, RD; Qualls, CR; Tuason, VB, 1999) |
| "Studies of treatment of PTSD with valproate were located using a search protocol which was applied to the electronic databases CINAHL, EMBASE, MEDLINE and PSYCHINFO." | 2.44 | Valproate in the treatment of PTSD: systematic review and meta analysis. ( Adamou, M; Hale, AS; Plummer, W; Puchalska, S, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (30.43) | 18.2507 |
| 2000's | 10 (43.48) | 29.6817 |
| 2010's | 6 (26.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jorge, RE | 1 |
| Li, R | 1 |
| Liu, X | 1 |
| McGavin, JK | 1 |
| Shorter, DI | 1 |
| Acion, L | 1 |
| Arndt, S | 1 |
| Wilson, CB | 1 |
| McLaughlin, LD | 1 |
| Ebenezer, PJ | 1 |
| Nair, AR | 1 |
| Francis, J | 1 |
| Wang, HR | 1 |
| Woo, YS | 1 |
| Bahk, WM | 1 |
| Baniasadi, M | 1 |
| Hosseini, G | 2 |
| Fayyazi Bordbar, MR | 2 |
| Rezaei Ardani, A | 2 |
| Mostafavi Toroghi, H | 2 |
| Talaei, A | 1 |
| Aukst-Margetić, B | 1 |
| Margetić, B | 1 |
| Huemer, J | 1 |
| Erhart, F | 1 |
| Steiner, H | 2 |
| Duggal, HS | 1 |
| Pathak, PC | 1 |
| Coleman, CC | 1 |
| Otte, C | 1 |
| Wiedemann, K | 1 |
| Yassouridis, A | 1 |
| Kellner, M | 1 |
| Green, B | 1 |
| Bourgeois, JA | 1 |
| Koike, AK | 1 |
| Simmons, JE | 1 |
| Telles, S | 1 |
| Eggleston, C | 1 |
| Li, S | 1 |
| Murakami, Y | 1 |
| Wang, M | 1 |
| Maeda, K | 1 |
| Matsumoto, K | 1 |
| Adamou, M | 1 |
| Puchalska, S | 1 |
| Plummer, W | 1 |
| Hale, AS | 1 |
| Saxena, KS | 1 |
| Carrion, V | 1 |
| Khanzode, LA | 1 |
| Silverman, M | 1 |
| Chang, K | 1 |
| Davis, LL | 1 |
| Davidson, JR | 1 |
| Ward, LC | 1 |
| Bartolucci, A | 1 |
| Bowden, CL | 1 |
| Petty, F | 1 |
| Berigan, TR | 1 |
| Holzgang, A | 1 |
| Ford, N | 1 |
| Vaquerizo, J | 1 |
| Romero-Rodríguez, JC | 1 |
| González-Roncero, A | 1 |
| Gómez-Marcos, A | 1 |
| Clark, RD | 1 |
| Cañive, JM | 1 |
| Calais, LA | 1 |
| Qualls, CR | 1 |
| Tuason, VB | 1 |
| Pearlstein, T | 1 |
| Keck, PE | 1 |
| McElroy, SL | 1 |
| Friedman, LM | 1 |
| Szymanski, HV | 1 |
| Olympia, J | 1 |
| Fesler, FA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pharmacogenetic Treatment With Anti-Glutaminergic Agents for Comorbid PTSD & AUD[NCT02884908] | Phase 3 | 252 participants (Anticipated) | Interventional | 2016-09-30 | Active, not recruiting | ||
| Divalproex Sodium in the Treatment of PTSD: A Placebo-Controlled Study[NCT00108576] | Phase 3 | 101 participants (Actual) | Interventional | 2003-10-31 | Completed | ||
| Maintenance Phase Treatment With Divalproex for Post Traumatic Stress Disorder[NCT00203385] | Phase 4 | 20 participants (Actual) | Interventional | 2003-05-31 | Terminated (stopped due to Funding expired) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for valproic acid and Stress Disorders, Post-Traumatic
| Article | Year |
|---|---|
Anticonvulsants to treat post-traumatic stress disorder.
Topics: Anti-Anxiety Agents; Anticonvulsants; Fructose; Humans; Lamotrigine; Nipecotic Acids; Stress Disorde | 2014 |
Posttraumatic stress disorder in children and adolescents: a review of psychopharmacological treatment.
Topics: Adolescent; Antidepressive Agents; Child; Humans; Imipramine; Randomized Controlled Trials as Topic; | 2010 |
Valproate in the treatment of PTSD: systematic review and meta analysis.
Topics: Antimanic Agents; Case-Control Studies; Clinical Trials as Topic; Humans; Research Design; Stress Di | 2007 |
Antidepressant treatment of posttraumatic stress disorder.
Topics: Anticonvulsants; Antidepressive Agents; Antidepressive Agents, Tricyclic; Clinical Trials as Topic; | 2000 |
Valproate and carbamazepine in the treatment of panic and posttraumatic stress disorders, withdrawal states, and behavioral dyscontrol syndromes.
Topics: Carbamazepine; Humans; Mental Disorders; Panic Disorder; Stress Disorders, Post-Traumatic; Substance | 1992 |
7 trials available for valproic acid and Stress Disorders, Post-Traumatic
| Article | Year |
|---|---|
Treating Alcohol Use Disorder in U.S. Veterans: The Role of Traumatic Brain Injury.
Topics: Adult; Alcohol Deterrents; Alcoholism; Brain Injuries, Traumatic; Comorbidity; Double-Blind Method; | 2019 |
Effect of pregabalin augmentation in treatment of patients with combat-related chronic posttraumatic stress disorder: a randomized controlled trial.
Topics: Adult; Anticonvulsants; Antidepressive Agents; Anxiety; Combat Disorders; Depression; Double-Blind M | 2014 |
Effect of Rivastigmine Augmentation in Treatment of Male Patients With Combat-Related Chronic Posttraumatic Stress Disorder: A Randomized Controlled Trial.
Topics: Adult; Cholinesterase Inhibitors; Chronic Disease; Combat Disorders; Double-Blind Method; Drug Syner | 2017 |
Divalproex sodium for the treatment of PTSD and conduct disordered youth: a pilot randomized controlled clinical trial.
Topics: Adolescent; Anticonvulsants; Comorbidity; Conduct Disorder; Dose-Response Relationship, Drug; Double | 2007 |
Divalproex in the treatment of posttraumatic stress disorder: a randomized, double-blind, placebo-controlled trial in a veteran population.
Topics: Chronic Disease; Combat Disorders; Delayed-Action Preparations; Double-Blind Method; Female; GABA Ag | 2008 |
Divalproex in posttraumatic stress disorder: an open-label clinical trial.
Topics: Adult; Aged; Antimanic Agents; Humans; Male; Middle Aged; Severity of Illness Index; Stress Disorder | 1999 |
Valproate in combat-related posttraumatic stress disorder.
Topics: Adult; Arousal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Therapy, Combin | 1991 |
11 other studies available for valproic acid and Stress Disorders, Post-Traumatic
| Article | Year |
|---|---|
Valproic acid effects in the hippocampus and prefrontal cortex in an animal model of post-traumatic stress disorder.
Topics: Animals; Anti-Anxiety Agents; Anxiety; Cats; Disease Models, Animal; Extinction, Psychological; Fear | 2014 |
Stuttering as a side-effect of divalproex sodium.
Topics: Alcoholism; Antimanic Agents; Humans; Male; Middle Aged; Stress Disorders, Post-Traumatic; Stutterin | 2008 |
Treating selective serotonin reuptake inhibitor-induced behavioral activation with valproate.
Topics: Adolescent; Adolescent Behavior; Behavioral Symptoms; Dysthymic Disorder; Female; Humans; Selective | 2003 |
Valproate monotherapy in the treatment of civilian patients with non-combat-related posttraumatic stress disorder: an open-label study.
Topics: Administration, Oral; Adult; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Stress | 2004 |
Key developments in psychiatry.
Topics: Antimanic Agents; Antipsychotic Agents; Bipolar Disorder; Cognitive Behavioral Therapy; Dementia; Hu | 2004 |
Adjunctive valproic acid for delirium and/or agitation on a consultation-liaison service: a report of six cases.
Topics: Alcohol Withdrawal Delirium; Alcoholism; Anticonvulsants; Delirium; Fever; Humans; Injections, Intra | 2005 |
The effects of chronic valproate and diazepam in a mouse model of posttraumatic stress disorder.
Topics: Animals; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Maze Learning; Mi | 2006 |
Valproate as an alternative in post-traumatic stress disorder: a case report.
Topics: Humans; Male; Stress Disorders, Post-Traumatic; United States; Valproic Acid; Veterans | 1995 |
The use of anticonvulsants in posttraumatic stress disorder: case study and overview.
Topics: Adult; Anticonvulsants; Carbamazepine; Depression; Humans; Male; Reflex, Startle; Stress Disorders, | 1996 |
[Partial complex status epilepticus: diagnostic difficulties].
Topics: Anticonvulsants; Child; Crime; Diagnosis, Differential; Drug Therapy, Combination; Electroencephalog | 1998 |
Divalproex in posttraumatic stress disorder.
Topics: Adult; Aggression; Disruptive, Impulse Control, and Conduct Disorders; Humans; Male; Stress Disorder | 1991 |