valproic acid has been researched along with Stomach Ulcer in 6 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Stomach Ulcer: Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).
| Excerpt | Relevance | Reference |
|---|---|---|
| "We describe the case of an adult man aged 49, without personal antecedents, or family psychiatric history, treated for bipolar disorder since 1995 and stabilised in the last 8 years by valproic acid, who presented in January 2010 an acute drug-induced pancreatitis." | 3.79 | [Acute pancreatitis induced by valproic acid]. ( Douki, S; Jomli, R; Nacef, F, 2013) |
| "The occurrence and characteristics of binding sites specific for gamma-aminobutyric acid (GABA) and muscimol in the rat stomach were examined by biochemical and autoradiographic techniques, and the effects of GABAergic model compounds on gastric ulceration induced by chemical irritation was studied in intact and unilaterally vagotomized rats." | 3.67 | GABAA receptors in the rat stomach may mediate mucoprotective effects. ( Amenta, F; Erdö, SL; Ezer, E; Matuz, J; Wolff, JR, 1989) |
| "The effect of exogenous administration of central amino acid neurotransmitters gamma-aminobutyric acid (GABA), glycine, glutamic acid and aspartic acid) into the cerebroventricular system was studied on gastric ulceration induced in albino rats either by 2 h restraint at 4 degrees C or by 6 h restraint at room temperature (30 +/- 2 degrees C)." | 3.67 | Central GABA-ergic mechanism in stress-induced gastric ulceration. ( Bhargava, KP; Gupta, GP; Gupta, MB, 1985) |
| "gamma-Aminobutyric acid (GABA) and sodium valproate (VPA) inhibit the formation of stress-induced gastric ulcers in guinea-pigs." | 3.67 | Protective effect of GABA and sodium valproate on stress-induced gastric lesions in guinea-pigs. ( Durán, JA; Miñano, FJ; Sancibrián, M; Serrano, JS, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (66.67) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jomli, R | 1 |
| Nacef, F | 1 |
| Douki, S | 1 |
| Bhowmick, S | 1 |
| Bose, R | 1 |
| Pal, M | 1 |
| Pal, SP | 1 |
| Erdö, SL | 1 |
| Ezer, E | 1 |
| Matuz, J | 1 |
| Wolff, JR | 1 |
| Amenta, F | 1 |
| Bhargava, KP | 2 |
| Gupta, GP | 2 |
| Gupta, MB | 2 |
| Miñano, FJ | 1 |
| Serrano, JS | 1 |
| Durán, JA | 1 |
| Sancibrián, M | 1 |
| Vrat, S | 1 |
| Nath, R | 1 |
6 other studies available for valproic acid and Stomach Ulcer
| Article | Year |
|---|---|
[Acute pancreatitis induced by valproic acid].
Topics: Anticonvulsants; Bipolar Disorder; Cooperative Behavior; Diagnosis, Differential; Drug Substitution; | 2013 |
Antiulcer activity of N-phthaloyl GABA--a new GABA mimetic agent.
Topics: 3-Mercaptopropionic Acid; Animals; Anti-Ulcer Agents; Bicuculline; Cimetidine; Dose-Response Relatio | 1990 |
GABAA receptors in the rat stomach may mediate mucoprotective effects.
Topics: Administration, Oral; Aminooxyacetic Acid; Animals; Anti-Ulcer Agents; Baclofen; Bicuculline; Bindin | 1989 |
Central GABA-ergic mechanism in stress-induced gastric ulceration.
Topics: Acetylcholine; Amino Acids; Animals; Aspartic Acid; Bicuculline; Cold Temperature; Epinephrine; Fema | 1985 |
Protective effect of GABA and sodium valproate on stress-induced gastric lesions in guinea-pigs.
Topics: Animals; Cold Temperature; Female; gamma-Aminobutyric Acid; Guinea Pigs; Injections, Intraperitoneal | 1985 |
Antiulcer activity of sodium valproate in rats and guinea pigs.
Topics: Animals; Cimetidine; Female; Guinea Pigs; Male; Rats; Stomach Ulcer; Valproic Acid | 1988 |