valproic acid has been researched along with Stomach Neoplasms in 11 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Stomach Neoplasms: Tumors or cancer of the STOMACH.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We found that 4 histone deacetylase inhibitors, trichostatin A (TSA), sodium butyrate (SB), valproic acid (VPA) and suberoylanilide hydroxamic acid (SAHA), all significantly induced EBV lytic cycle in EBV-positive gastric carcinoma cells (AGS/BX1, latency II) but only weakly induced in Burkitt lymphoma cells (AK2003, latency I) and did not induce in lymphoblastoid cells (LCLs, latency III)." | 3.76 | Suberoylanilide hydroxamic acid induces viral lytic cycle in Epstein-Barr virus-positive epithelial malignancies and mediates enhanced cell death. ( Chiang, AK; Hui, KF, 2010) |
| "Valproic acid (VPA) is a HDACI with reported controversial effects on the EMT." | 1.62 | Evaluation of the Effects of Valproic Acid Treatment on Cell Survival and Epithelial-Mesenchymal Transition-Related Features of Human Gastric Cancer Cells. ( Jahani, M; Khanahmad, H; Nikpour, P, 2021) |
| "Currently, no transplantable gastric cancer syngeneic animal models exist; therefore, we set out to establish a mouse gastric carcinoma cell line, which was named mouse gastric carcinoma cell line 3I (MGCC3I), from forestomach carcinoma developed in benzo[a]pyrene-treated ICR mice." | 1.37 | Establishment of an orthotopic transplantable gastric cancer animal model for studying the immunological effects of new cancer therapeutic modules. ( Chen, YL; Fang, JH; Hsu, HP; Lai, MD; Lin, CY; Lin, PW; Shan, YS; Yen, MC, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 7 (63.64) | 24.3611 |
| 2020's | 2 (18.18) | 2.80 |
| Authors | Studies |
|---|---|
| Sun, J | 1 |
| Piao, J | 1 |
| Li, N | 1 |
| Yang, Y | 1 |
| Kim, KY | 1 |
| Lin, Z | 1 |
| Jahani, M | 1 |
| Khanahmad, H | 1 |
| Nikpour, P | 1 |
| Fushida, S | 2 |
| Kinoshita, J | 2 |
| Kaji, M | 1 |
| Oyama, K | 2 |
| Hirono, Y | 1 |
| Tsukada, T | 1 |
| Fujimura, T | 2 |
| Ohta, T | 2 |
| Hui, KF | 1 |
| Chiang, AK | 1 |
| Mutze, K | 1 |
| Langer, R | 1 |
| Becker, K | 1 |
| Ott, K | 1 |
| Novotny, A | 1 |
| Luber, B | 1 |
| Hapfelmeier, A | 1 |
| Göttlicher, M | 1 |
| Höfler, H | 1 |
| Keller, G | 1 |
| Shan, YS | 1 |
| Fang, JH | 1 |
| Lai, MD | 1 |
| Yen, MC | 1 |
| Lin, PW | 1 |
| Hsu, HP | 1 |
| Lin, CY | 1 |
| Chen, YL | 1 |
| Yagi, Y | 1 |
| Harada, S | 1 |
| Makino, I | 1 |
| Tajima, H | 1 |
| Fujita, H | 1 |
| Takamura, H | 1 |
| Ninomiya, I | 1 |
| Yashiro, M | 1 |
| Hirakawa, K | 1 |
| Zhao, X | 2 |
| Yang, W | 1 |
| Shi, C | 1 |
| Ma, W | 1 |
| Liu, J | 1 |
| Wang, Y | 1 |
| Jiang, G | 1 |
| Wong, CC | 1 |
| Cheng, KW | 1 |
| Xie, G | 1 |
| Zhou, D | 1 |
| Zhu, CH | 1 |
| Constantinides, PP | 1 |
| Rigas, B | 1 |
| Feng, WH | 1 |
| Kenney, SC | 1 |
| Shi, CW | 1 |
| Cao, LL | 1 |
| Sun, JJ | 1 |
| Liu, AW | 1 |
1 trial available for valproic acid and Stomach Neoplasms
| Article | Year |
|---|---|
Paclitaxel plus valproic acid versus paclitaxel alone as second- or third-line therapy for advanced gastric cancer: a randomized Phase II trial.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Humans; Japan | 2016 |
10 other studies available for valproic acid and Stomach Neoplasms
| Article | Year |
|---|---|
Valproic acid targets HDAC1/2 and HDAC1/PTEN/Akt signalling to inhibit cell proliferation via the induction of autophagy in gastric cancer.
Topics: Animals; Apoptosis; Autophagy; Beclin-1; Cell Line, Tumor; Cell Proliferation; Gene Expression Regul | 2020 |
Evaluation of the Effects of Valproic Acid Treatment on Cell Survival and Epithelial-Mesenchymal Transition-Related Features of Human Gastric Cancer Cells.
Topics: Antigens, CD; Apoptosis; Cadherins; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Surviv | 2021 |
Suberoylanilide hydroxamic acid induces viral lytic cycle in Epstein-Barr virus-positive epithelial malignancies and mediates enhanced cell death.
Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Burkitt Lymphoma; Butyrates; Carcinoma; Cell Cy | 2010 |
Histone deacetylase (HDAC) 1 and 2 expression and chemotherapy in gastric cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Clinical Trials, Phase II as | 2010 |
Establishment of an orthotopic transplantable gastric cancer animal model for studying the immunological effects of new cancer therapeutic modules.
Topics: Animals; Blotting, Western; Butyrates; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Cyclin E; Disea | 2011 |
Effects of valproic acid on the cell cycle and apoptosis through acetylation of histone and tubulin in a scirrhous gastric cancer cell line.
Topics: Acetylation; Adenocarcinoma, Scirrhous; Animals; Antineoplastic Agents; Apoptosis; Blotting, Western | 2010 |
The G1 phase arrest and apoptosis by intrinsic pathway induced by valproic acid inhibit proliferation of BGC-823 gastric carcinoma cells.
Topics: Apoptosis; Caspase 3; Caspase 9; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cell Sur | 2011 |
Carboxylesterases 1 and 2 hydrolyze phospho-nonsteroidal anti-inflammatory drugs: relevance to their pharmacological activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Carboxylesterase; Carboxylic Ester Hydrol | 2012 |
Valproic acid enhances the efficacy of chemotherapy in EBV-positive tumors by increasing lytic viral gene expression.
Topics: Animals; Cell Line, Tumor; Dose-Response Relationship, Drug; Epstein-Barr Virus Infections; Gene Exp | 2006 |
[Effect of valproate acid sodium on apoptosis of human gastric cancer cells and its mechanism study].
Topics: Apoptosis; Caspases; Cell Line, Tumor; Humans; Stomach Neoplasms; Valproic Acid | 2007 |