valproic acid has been researched along with Stiff-Person Syndrome in 6 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Stiff-Person Syndrome: A condition characterized by persistent spasms (SPASM) involving multiple muscles, primarily in the lower limbs and trunk. The illness tends to occur in the fourth to sixth decade of life, presenting with intermittent spasms that become continuous. Minor sensory stimuli, such as noise and light touch, precipitate severe spasms. Spasms do not occur during sleep and only rarely involve cranial muscles. Respiration may become impaired in advanced cases. (Adams et al., Principles of Neurology, 6th ed, p1492; Neurology 1998 Jul;51(1):85-93)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 4 (66.67) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Martínez-Rivera, V | 1 |
| Martínez-Antón, J | 1 |
| Sakai, K | 2 |
| Rüegg, SJ | 1 |
| Steck, AJ | 1 |
| Fuhr, P | 1 |
| Mihajlovic-Madzarevic, V | 1 |
| Pappas, P | 1 |
| Sevrin, C | 1 |
| Moulin, T | 1 |
| Tatu, L | 1 |
| Monnier, G | 1 |
| Rumbach, L | 1 |
| Sevrin, P | 1 |
2 reviews available for valproic acid and Stiff-Person Syndrome
| Article | Year |
|---|---|
[Stiff-person syndrome].
Topics: Animals; Autoantibodies; Autoimmunity; Diabetes Mellitus, Type 1; Diagnosis, Differential; Diazepam; | 2002 |
[Stiff-man syndrome].
Topics: Autoantibodies; Diabetes Mellitus, Type 1; Diagnosis, Differential; Diazepam; GABA Agents; gamma-Ami | 2000 |
4 other studies available for valproic acid and Stiff-Person Syndrome
| Article | Year |
|---|---|
[Hyperekplexia associated to precocious puberty].
Topics: Anticonvulsants; Benzodiazepines; Cerebral Palsy; Child; Clobazam; Drug Therapy, Combination; Electr | 2015 |
Levetiracetam improves paroxysmal symptoms in a patient with stiff-person syndrome.
Topics: Female; GABA Agonists; Humans; Immunoglobulins, Intravenous; Levetiracetam; Middle Aged; Muscle Spas | 2004 |
Treatment of refractory seizures due to a benign mass present in the corpus callosum with an ion magnetic inductor: case report.
Topics: Adult; Agenesis of Corpus Callosum; Anticonvulsants; Colchicine; Combined Modality Therapy; Corpus C | 2005 |
["Stiff-man" syndrome treated with intravenous immunoglobulins].
Topics: Diazepam; Humans; Immunoglobulins, Intravenous; Male; Middle Aged; Muscle Contraction; Stiff-Person | 1998 |