valproic acid has been researched along with Stevens-Johnson Syndrome in 32 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Stevens-Johnson Syndrome: Rare cutaneous eruption characterized by extensive KERATINOCYTE apoptosis resulting in skin detachment with mucosal involvement. It is often provoked by the use of drugs (e.g., antibiotics and anticonvulsants) or associated with PNEUMONIA, MYCOPLASMA. It is considered a continuum of Toxic Epidermal Necrolysis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study investigated the association between 2 mood stabilizers (carbamazepine and valproate) and other medications (including other anticonvulsants) and the risks of erythema multiforme (EM), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) among patients with bipolar disorder." | 7.74 | The association between carbamazepine and valproate and adverse cutaneous drug reactions in patients with bipolar disorder: a nested matched case-control study. ( Chang, CJ; Chao, PF; Gau, CS; Gau, SS; Lin, YJ, 2008) |
| "Valproic acid (VPA) is a commonly used antiepileptic drug (AED)." | 6.61 | Valproic acid and Stevens-Johnson syndrome: a systematic review of descriptive studies. ( Kashyap, A; Rashid, M; Undela, K, 2019) |
| "Lamotrigine (LTG) is a novel antiepileptic drug effective in partial and generalized seizures." | 5.31 | Stevens-Johnson syndrome associated with concomitant use of lamotrigine and valproic acid. ( Karaduman, A; Yalçin, B, 2000) |
| "We systematically reviewed and analyzed published patients with Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN) associated with lamotrigine therapy to identify characteristics of these reactions." | 4.91 | Lamotrigine-induced severe cutaneous adverse reaction: Update data from 1999-2014. ( Huang, XS; Lang, SY; Lv, B; Tian, CL; Wang, HF; Wang, XQ; Yu, SY; Zhang, JT; Zhang, X, 2015) |
| "We systematically reviewed and analyzed published and unpublished cases of Stevens-Johnson syndrome (SJS), or toxic epidermal necrolysis (TEN) associated with lamotrigine (LTG) therapy to identify characteristics of these reactions." | 4.80 | Lamotrigine-induced severe cutaneous adverse reactions. ( Schlienger, RG; Shapiro, LE; Shear, NH, 1998) |
| "We describe the case history of a 9-year-old boy who developed Stevens-Johnson syndrome (SJS) following concomitant use of valproic acid and lamotrigine." | 3.85 | Stevens - Johnson Syndrome Induced by Combination of Lamotrigine and Valproic Acid in a 9-Year-Old Boy. ( Buckley, D; Maduemem, K; O'Neill, T; Vatca, A, 2017) |
| "This study investigated the association between 2 mood stabilizers (carbamazepine and valproate) and other medications (including other anticonvulsants) and the risks of erythema multiforme (EM), Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) among patients with bipolar disorder." | 3.74 | The association between carbamazepine and valproate and adverse cutaneous drug reactions in patients with bipolar disorder: a nested matched case-control study. ( Chang, CJ; Chao, PF; Gau, CS; Gau, SS; Lin, YJ, 2008) |
| "Across a range of assumptions used, the risk of hospitalization for Stevens-Johnson syndrome or toxic epidermal necrolysis in new users is low for carbamazepine, lamotrigine, phenytoin, phenobarbital, and valproic acid." | 3.73 | Risk of Stevens-Johnson syndrome and toxic epidermal necrolysis in new users of antiepileptics. ( Messenheimer, J; Mockenhaupt, M; Schlingmann, J; Tennis, P, 2005) |
| "Valproic acid (VPA) is a commonly used antiepileptic drug (AED)." | 2.61 | Valproic acid and Stevens-Johnson syndrome: a systematic review of descriptive studies. ( Kashyap, A; Rashid, M; Undela, K, 2019) |
| "This study was undertaken to determine the impact of dosage in new users of lamotrigine (LTG) and the concomitant intake of valproic acid (VPA) on epidermal necrolysis (EN)." | 1.91 | Effects of dosage in new users of lamotrigine inducing epidermal necrolysis: Results of the German Registry of Severe Skin Reactions. ( Diederich, S; Hemmeter, U; Mockenhaupt, M; Paulmann, M, 2023) |
| "Epilepsy is very difficult to treat and often involves the combination of two or more AEDs." | 1.56 | Antiepileptic combination therapy with Stevens-Johnson syndrome and toxic epidermal necrolysis: Analysis of a Japanese pharmacovigilance database. ( Hayashi, T; Noguchi, Y; Tachi, T; Takaoka, M; Teramachi, H, 2020) |
| "Previously, we reported a fatal case of toxic epidermal necrolysis with hyperbilirubinemia, and more than 60% of body surface areas had been eroded for 9 weeks." | 1.36 | Toxic epidermal necrolysis with severe hyperbilirubinemia: complete re-epithelialization after bilirubin reduction therapies. ( Hirasawa, H; Kamada, N; Matsuda, K; Matsue, H; Oda, S; Shinkai, H; Suehiro, K; Togawa, Y; Yokota, M; Yoneyama, K, 2010) |
| "Most cases of toxic epidermal necrolysis are drug induced." | 1.32 | Suspected lamotrigine-induced toxic epidermal necrolysis. ( Demiralay, E; Kilinç, M; Söğüt, A; Söğüt, AG; Uzar, H; Yilmaz, A, 2003) |
| "Lamotrigine (LTG) is a novel antiepileptic drug effective in partial and generalized seizures." | 1.31 | Stevens-Johnson syndrome associated with concomitant use of lamotrigine and valproic acid. ( Karaduman, A; Yalçin, B, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (25.00) | 18.2507 |
| 2000's | 13 (40.63) | 29.6817 |
| 2010's | 8 (25.00) | 24.3611 |
| 2020's | 3 (9.38) | 2.80 |
| Authors | Studies |
|---|---|
| Almuhana, G | 1 |
| Alsalhi, A | 1 |
| Alsalhi, H | 1 |
| Al-Hoqail, IA | 1 |
| Diederich, S | 1 |
| Hemmeter, U | 1 |
| Paulmann, M | 1 |
| Mockenhaupt, M | 2 |
| Noguchi, Y | 1 |
| Takaoka, M | 1 |
| Hayashi, T | 1 |
| Tachi, T | 1 |
| Teramachi, H | 1 |
| Maduemem, K | 1 |
| Vatca, A | 1 |
| O'Neill, T | 1 |
| Buckley, D | 1 |
| Rashid, M | 1 |
| Kashyap, A | 1 |
| Undela, K | 1 |
| Barbour, KK | 1 |
| Umfrid, CP | 1 |
| Brinton, BA | 1 |
| Avery, JD | 1 |
| Snow, CE | 1 |
| Saaiq, M | 1 |
| Iqbal, T | 1 |
| Wang, XQ | 1 |
| Lv, B | 1 |
| Wang, HF | 1 |
| Zhang, X | 1 |
| Yu, SY | 1 |
| Huang, XS | 1 |
| Zhang, JT | 1 |
| Tian, CL | 1 |
| Lang, SY | 1 |
| Ordoñez, L | 1 |
| Salgueiro, E | 1 |
| Jimeno, FJ | 1 |
| Manso, G | 1 |
| Gau, SS | 1 |
| Chao, PF | 1 |
| Lin, YJ | 1 |
| Chang, CJ | 1 |
| Gau, CS | 1 |
| Ertam, I | 1 |
| Sezgin, AO | 1 |
| Unal, I | 1 |
| Franciotta, D | 1 |
| Kwan, P | 1 |
| Perucca, E | 1 |
| Guevara-Campos, J | 1 |
| González-De Guevara, L | 1 |
| Berardi-Lorenzón, ML | 1 |
| Ibrahim, G | 1 |
| Mejías, P | 1 |
| Agelvis, MC | 1 |
| Kamada, N | 1 |
| Yoneyama, K | 1 |
| Togawa, Y | 1 |
| Suehiro, K | 1 |
| Shinkai, H | 1 |
| Yokota, M | 1 |
| Matsuda, K | 1 |
| Oda, S | 1 |
| Hirasawa, H | 1 |
| Matsue, H | 1 |
| Söğüt, A | 1 |
| Yilmaz, A | 1 |
| Kilinç, M | 1 |
| Söğüt, AG | 1 |
| Demiralay, E | 1 |
| Uzar, H | 1 |
| Hashim, N | 1 |
| Bandara, D | 1 |
| Tan, E | 1 |
| Ilchyshyn, A | 1 |
| Famularo, G | 1 |
| De Simone, C | 1 |
| Minisola, G | 1 |
| Messenheimer, J | 1 |
| Tennis, P | 1 |
| Schlingmann, J | 1 |
| Fein, JD | 1 |
| Hamann, KL | 1 |
| Chang, CC | 1 |
| Shiah, IS | 1 |
| Chang, HA | 1 |
| Huang, SY | 1 |
| Kocak, S | 1 |
| Girisgin, SA | 1 |
| Gul, M | 1 |
| Cander, B | 1 |
| Kaya, H | 1 |
| Kaya, E | 1 |
| Keating, A | 1 |
| Blahunka, P | 1 |
| Duval, X | 1 |
| Chosidow, O | 1 |
| Semah, F | 1 |
| Lipsker, D | 1 |
| Francès, C | 1 |
| Herson, S | 1 |
| Sachs, B | 1 |
| Rönnau, AC | 1 |
| von Schmiedeberg, S | 1 |
| Ruzicka, T | 1 |
| Gleichmann, E | 1 |
| Schuppe, HC | 1 |
| Vukelíc, D | 1 |
| Bozinović, D | 1 |
| Tesović, G | 1 |
| Dobrić, I | 1 |
| Loncarić, D | 1 |
| Knezović, I | 1 |
| Skerlev, M | 1 |
| Tsai, SJ | 1 |
| Chen, YS | 1 |
| Schlienger, RG | 1 |
| Shapiro, LE | 1 |
| Shear, NH | 1 |
| Elston, DM | 1 |
| Dunn, N | 1 |
| Wilton, L | 1 |
| Shakir, S | 1 |
| Bhushan, M | 1 |
| Brooke, R | 1 |
| Hewitt-Symonds, M | 1 |
| Craven, NM | 1 |
| August, PJ | 1 |
| Yalçin, B | 1 |
| Karaduman, A | 1 |
4 reviews available for valproic acid and Stevens-Johnson Syndrome
| Article | Year |
|---|---|
Valproic acid and Stevens-Johnson syndrome: a systematic review of descriptive studies.
Topics: Anticonvulsants; Antimanic Agents; Bipolar Disorder; Dose-Response Relationship, Drug; Epilepsy; Hum | 2019 |
Lamotrigine-induced severe cutaneous adverse reaction: Update data from 1999-2014.
Topics: Adult; Aged; Anticonvulsants; Drug Therapy, Combination; Female; Humans; Lamotrigine; Male; Middle A | 2015 |
Genetic basis for idiosyncratic reactions to antiepileptic drugs.
Topics: Anticonvulsants; Carbamazepine; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Epile | 2009 |
Lamotrigine-induced severe cutaneous adverse reactions.
Topics: Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combin | 1998 |
28 other studies available for valproic acid and Stevens-Johnson Syndrome
| Article | Year |
|---|---|
New insight into the management of toxic epidermal necrolysis following the coadministration of lamotrigine and valproic acid.
Topics: Anticonvulsants; Humans; Lamotrigine; Stevens-Johnson Syndrome; Triazines; Valproic Acid | 2023 |
Effects of dosage in new users of lamotrigine inducing epidermal necrolysis: Results of the German Registry of Severe Skin Reactions.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Humans; Lamotrigine; Male; Registries; Stevens-Johnson Syn | 2023 |
Antiepileptic combination therapy with Stevens-Johnson syndrome and toxic epidermal necrolysis: Analysis of a Japanese pharmacovigilance database.
Topics: Anticonvulsants; Carbamazepine; Clobazam; Clonazepam; Databases, Factual; Drug Therapy, Combination; | 2020 |
Stevens - Johnson Syndrome Induced by Combination of Lamotrigine and Valproic Acid in a 9-Year-Old Boy.
Topics: Anticonvulsants; Child; Drug Therapy, Combination; Humans; Lamotrigine; Male; Stevens-Johnson Syndro | 2017 |
A Case of Stevens-Johnson Syndrome After Exposure to Valproic Acid.
Topics: Antipsychotic Agents; Bipolar Disorder; Female; Humans; Stevens-Johnson Syndrome; Valproic Acid | 2019 |
Report: Fatal toxic epidermal necrolysis induced by sodium valproate.
Topics: Adult; Epilepsy; Fatal Outcome; Humans; Male; Stevens-Johnson Syndrome; Valproic Acid | 2013 |
Spontaneous reporting of Stevens-Johnson syndrome and toxic epidermal necrolysis associated with antiepileptic drugs.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amines; Anticonvulsants; Carbamazepine; Child; Child, Pr | 2015 |
The association between carbamazepine and valproate and adverse cutaneous drug reactions in patients with bipolar disorder: a nested matched case-control study.
Topics: Acetaminophen; Adult; Anticonvulsants; Antimanic Agents; Bipolar Disorder; Carbamazepine; Case-Contr | 2008 |
A case with Stevens Johnson syndrome triggered by combination of clobazam, lamotrigine, and valproic acid treatment.
Topics: Anticonvulsants; Benzodiazepines; Child, Preschool; Clobazam; Drug Therapy, Combination; Follow-Up S | 2009 |
[Toxic epidermal necrolysis associated to the use of valproic acid].
Topics: Anticonvulsants; Child, Preschool; Female; Humans; Stevens-Johnson Syndrome; Valproic Acid | 2010 |
Toxic epidermal necrolysis with severe hyperbilirubinemia: complete re-epithelialization after bilirubin reduction therapies.
Topics: Aged; Anticonvulsants; Fatal Outcome; Female; Humans; Hyperbilirubinemia; Plasma Exchange; Sorption | 2010 |
Suspected lamotrigine-induced toxic epidermal necrolysis.
Topics: Adult; Anticonvulsants; Drug Therapy, Combination; Female; Humans; Lamotrigine; Myoclonic Epilepsy, | 2003 |
Early cyclosporine treatment of incipient toxic epidermal necrolysis induced by concomitant use of lamotrigine and sodium valproate.
Topics: Adult; Anticonvulsants; Cyclosporine; Dermatologic Agents; Drug Therapy, Combination; Epilepsy, Comp | 2004 |
Stevens-Johnson syndrome associated with single high dose of lamotrigine in a patient taking valproate.
Topics: Adult; Anticonvulsants; Drug Interactions; Epilepsy, Tonic-Clonic; Humans; Lamotrigine; Male; Steven | 2005 |
Risk of Stevens-Johnson syndrome and toxic epidermal necrolysis in new users of antiepileptics.
Topics: Anticonvulsants; Carbamazepine; Causality; Epilepsy; Germany; Humans; Incidence; Inpatients; Lamotri | 2005 |
Images in clinical medicine. Stevens-Johnson syndrome.
Topics: Adult; Anticonvulsants; Drug Synergism; Female; Humans; Lamotrigine; Stevens-Johnson Syndrome; Triaz | 2005 |
Toxic epidermal necrolysis with combination lamotrigine and valproate in bipolar disorder.
Topics: Adult; Anticonvulsants; Bipolar Disorder; Drug Therapy, Combination; Female; Humans; Lamotrigine; St | 2006 |
Stevens-Johnson syndrome due to concomitant use of lamotrigine and valproic acid.
Topics: Adult; Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsy; Female; Humans; Lamotrig | 2007 |
Carbamazepine-induced Stevens-Johnson syndrome in a child.
Topics: Anti-Bacterial Agents; Carbamazepine; Child; Drug Therapy, Combination; Epilepsy, Generalized; Human | 1995 |
Lamotrigine versus carbamazepine in epilepsy.
Topics: Adult; Anticonvulsants; Clonazepam; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Humans; Lamotrigi | 1995 |
Lamotrigine-induced Stevens-Johnson syndrome: demonstration of specific lymphocyte reactivity in vitro.
Topics: Adult; Anticonvulsants; Concanavalin A; Drug Eruptions; Drug Therapy, Combination; Half-Life; Humans | 1997 |
Lamotrigine and toxic epidermal necrolysis.
Topics: Anticonvulsants; Drug Therapy, Combination; Humans; Infant; Lamotrigine; Male; Stevens-Johnson Syndr | 1997 |
Valproic acid-induced Stevens-Johnson syndrome.
Topics: Adult; Anticonvulsants; Drug Therapy, Combination; Epilepsies, Myoclonic; Humans; Male; Stevens-John | 1998 |
Photo Quiz.
Topics: Aged; Anticonvulsants; Drug Interactions; Epilepsy; Female; Humans; Lamotrigine; Skin; Stevens-Johns | 1999 |
Stevens-Johnson syndrome and antiepileptics.
Topics: Adult; Anticonvulsants; Child; Drug Therapy, Combination; Epilepsy; Humans; Lamotrigine; Stevens-Joh | 1999 |
Prolonged toxic epidermal necrolysis due to Lamotrigine.
Topics: Adult; Anticonvulsants; Drug Interactions; Humans; Lamotrigine; Male; Seizures; Stevens-Johnson Synd | 2000 |
Stevens-Johnson syndrome associated with concomitant use of lamotrigine and valproic acid.
Topics: Adult; Anticonvulsants; Antimanic Agents; Drug Therapy, Combination; Female; Humans; Lamotrigine; Ps | 2000 |
Valproate and other anticonvulsants for psychiatric disorders.
Topics: Abnormalities, Drug-Induced; Acetates; Adult; Amines; Anti-Anxiety Agents; Anticonvulsants; Bipolar | 2000 |