valproic acid has been researched along with Spinocerebellar Ataxias in 2 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Spinocerebellar Ataxias: A group of predominately late-onset, cerebellar ataxias which have been divided into multiple subtypes based on clinical features and genetic mapping. Progressive ataxia is a central feature of these conditions, and in certain subtypes POLYNEUROPATHY; DYSARTHRIA; visual loss; and other disorders may develop. (From Joynt, Clinical Neurology, 1997, Ch65, pp 12-17; J Neuropathol Exp Neurol 1998 Jun;57(6):531-43)
| Excerpt | Relevance | Reference |
|---|---|---|
| " We identified a patient with a positive family history for episodic ataxia, who was originally diagnosed with epilepsy and treated with valproic acid." | 3.73 | CACNA1A mutation in a EA-2 patient responsive to acetazolamide and valproic acid. ( Bulman, DE; Friedman, JH; Scoggan, KA, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Scoggan, KA | 1 |
| Friedman, JH | 1 |
| Bulman, DE | 1 |
| Kanai, K | 1 |
| Sakakibara, R | 1 |
| Uchiyama, T | 1 |
| Liu, Z | 1 |
| Yamamoto, T | 1 |
| Ito, T | 1 |
| Hirano, S | 1 |
| Asahina, M | 1 |
| Kuwabara, S | 1 |
| Hattori, T | 1 |
| Fukami, G | 1 |
| Arai, K | 1 |
| Yamaguchi, C | 1 |
| Nomura, F | 1 |
2 other studies available for valproic acid and Spinocerebellar Ataxias
| Article | Year |
|---|---|
CACNA1A mutation in a EA-2 patient responsive to acetazolamide and valproic acid.
Topics: Acetazolamide; Adult; Amino Acid Sequence; Animals; Anticonvulsants; Calcium Channels; Diagnosis, Di | 2006 |
Sporadic case of spinocerebellar ataxia type 17: treatment observations for managing urinary and psychotic symptoms.
Topics: Anticonvulsants; Electromyography; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Psychotic | 2007 |