valproic acid has been researched along with Spina Bifida Aperta in 5 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The antiepileptic drug valproic acid (VPA) has been implicated as a human teratogen causing spina bifida aperta." | 7.68 | Spina bifida aperta induced by valproic acid and by all-trans-retinoic acid in the mouse: distinct differences in morphology and periods of sensitivity. ( Ehlers, K; Merker, HJ; Nau, H; Stürje, H, 1992) |
| " Among 92 pregnancies with maternal valproic acid use, five (including one concordantly affected monozygotic twin-pair) were terminated because of a spina bifida aperta, all prenatally diagnosed by AFP determination and acetylcholinesterase electrophoresis in amniotic fluid." | 3.68 | Prenatal diagnosis of spina bifida aperta after first-trimester valproate exposure. ( Hagenaars, AM; Lindhout, D; Los, FJ; Omtzigt, JG; Sachs, ES; Stewart, PA, 1992) |
| "Prenatal exposure to the antiepileptic drug valproic acid (VPA) has been associated with the formation of spina bifida aperta, meningocele, and meningomyelocele in the human." | 3.68 | Valproic acid-induced spina bifida: a mouse model. ( Ehlers, K; Merker, HJ; Nau, H; Stürje, H, 1992) |
| "The antiepileptic drug valproic acid (VPA) has been implicated as a human teratogen causing spina bifida aperta." | 3.68 | Spina bifida aperta induced by valproic acid and by all-trans-retinoic acid in the mouse: distinct differences in morphology and periods of sensitivity. ( Ehlers, K; Merker, HJ; Nau, H; Stürje, H, 1992) |
| " Spina bifida aperta has been linked specifically to valproic acid (VPA) (estimated risk, 1 to 2%)." | 3.68 | The risk of spina bifida aperta after first-trimester exposure to valproate in a prenatal cohort. ( Brandenburg, H; Gaillard, HL; Grobbee, DE; Jahoda, MG; Los, FJ; Omtzigt, JG; Pijpers, L; Sachs, ES; Stewart, PA; Wladimiroff, JW, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Guibaud, S | 1 |
| Robert, E | 1 |
| Simplot, A | 1 |
| Boisson, C | 1 |
| Francannet, C | 1 |
| Patouraux, MH | 1 |
| Omtzigt, JG | 2 |
| Los, FJ | 2 |
| Hagenaars, AM | 1 |
| Stewart, PA | 2 |
| Sachs, ES | 2 |
| Lindhout, D | 1 |
| Ehlers, K | 2 |
| Stürje, H | 2 |
| Merker, HJ | 2 |
| Nau, H | 2 |
| Grobbee, DE | 1 |
| Pijpers, L | 1 |
| Jahoda, MG | 1 |
| Brandenburg, H | 1 |
| Gaillard, HL | 1 |
| Wladimiroff, JW | 1 |
1 review available for valproic acid and Spina Bifida Aperta
| Article | Year |
|---|---|
Prenatal diagnosis of spina bifida aperta after first-trimester valproate exposure.
Topics: Female; Humans; Pregnancy; Pregnancy Trimester, First; Prenatal Diagnosis; Spina Bifida Cystica; Val | 1993 |
4 other studies available for valproic acid and Spina Bifida Aperta
| Article | Year |
|---|---|
Prenatal diagnosis of spina bifida aperta after first-trimester valproate exposure.
Topics: Acetylcholinesterase; alpha-Fetoproteins; Amniotic Fluid; Female; Humans; Pregnancy; Pregnancy Trime | 1992 |
Valproic acid-induced spina bifida: a mouse model.
Topics: Abnormalities, Drug-Induced; Animals; Disease Models, Animal; Female; Mice; Mice, Inbred Strains; Pr | 1992 |
Spina bifida aperta induced by valproic acid and by all-trans-retinoic acid in the mouse: distinct differences in morphology and periods of sensitivity.
Topics: Animals; Dose-Response Relationship, Drug; Gestational Age; Mice; Spina Bifida Cystica; Teratogens; | 1992 |
The risk of spina bifida aperta after first-trimester exposure to valproate in a prenatal cohort.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Fetal Diseases; Humans; Infant; Infant, Newborn; Male; Pre | 1992 |