valproic acid has been researched along with Spasms, Infantile in 93 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Spasms, Infantile: An epileptic syndrome characterized by the triad of infantile spasms, hypsarrhythmia, and arrest of psychomotor development at seizure onset. The majority present between 3-12 months of age, with spasms consisting of combinations of brief flexor or extensor movements of the head, trunk, and limbs. The condition is divided into two forms: cryptogenic (idiopathic) and symptomatic (secondary to a known disease process such as intrauterine infections; nervous system abnormalities; BRAIN DISEASES, METABOLIC, INBORN; prematurity; perinatal asphyxia; TUBEROUS SCLEROSIS; etc.). (From Menkes, Textbook of Child Neurology, 5th ed, pp744-8)
| Excerpt | Relevance | Reference |
|---|---|---|
| "This is the first multicenter Italian experience with rufinamide as an adjunctive drug in children, adolescents and adults with Lennox-Gastaut syndrome." | 9.14 | Rufinamide in children and adults with Lennox-Gastaut syndrome: first Italian multicenter experience. ( Balestri, A; Capovilla, G; Coppola, G; Curatolo, P; Fels, A; Franzoni, E; Grosso, S; Habetswallner, F; Mangano, S; Parisi, P; Pascotto, A; Spalice, A; Veggiotti, P; Verrotti, A; Zamponi, N, 2010) |
| " We report an infant with SCAD deficiency who unexpectedly exhibited an extremely high blood concentration of valproic acid (VPA) and agranulocytosis." | 8.02 | Unexpected elevation in valproic acid concentration and agranulocytosis in a patient with short-chain acyl-CoA dehydrogenase deficiency. ( Eto, K; Hara, K; Ito, S; Nagata, S; Nishikawa, A; Oguni, H; Otani, Y; Suzuki, Y, 2021) |
| " At day 58 after birth, oral high-dose phenobarbital therapy was introduced which resulted in the suppression of seizures to one or two per week and disappearance of the burst-suppression pattern on EEG." | 7.91 | A case of early myoclonic encephalopathy with intractable seizures successfully treated with high-dose phenobarbital. ( Kawatani, M; Kometani, H; Kosaka, T; Ohshima, Y; Ohta, G, 2019) |
| "Fenfluramine (FFA), an antiseizure medication (ASM) indicated for treating convulsive seizures in Dravet syndrome, was assessed in six patients (five female; 83%) with CDD whose seizures had failed 5-12 ASMs or therapies." | 5.62 | Effect of fenfluramine on convulsive seizures in CDKL5 deficiency disorder. ( Conway, E; Devinsky, O; King, L; Price, D; Schwartz, D, 2021) |
| "Clonic seizures were rare in NMDA-treated P25 rats, but valproate pretreatment increased their incidence significantly." | 5.36 | Vigabatrin but not valproate prevents development of age-specific flexion seizures induced by N-methyl-D-aspartate (NMDA) in immature rats. ( Kubová, H; Mares, P, 2010) |
| "This is the first multicenter Italian experience with rufinamide as an adjunctive drug in children, adolescents and adults with Lennox-Gastaut syndrome." | 5.14 | Rufinamide in children and adults with Lennox-Gastaut syndrome: first Italian multicenter experience. ( Balestri, A; Capovilla, G; Coppola, G; Curatolo, P; Fels, A; Franzoni, E; Grosso, S; Habetswallner, F; Mangano, S; Parisi, P; Pascotto, A; Spalice, A; Veggiotti, P; Verrotti, A; Zamponi, N, 2010) |
| "The drug encorat, an analogue of valproic acid (Sun, India) was given to 16 children aged from 4 month to 5 years suffering from resistant forms of early infantile epilepsy." | 5.07 | [The enkorat treatment of infantile spasms and the Lennox-Gastaut syndrome]. ( Badalian, LO; Iskander, MB; Kharlamov, DA; Medvedev, MI; Mukhin, KIu; Temin, PA; Veselov, NK, 1994) |
| " The point estimates of carbamazepine and lamotrigine efficacy showed their superiority with respect to all comparator antiepileptic drugs for the treatment of newly diagnosed focal epilepsy." | 4.98 | Comparative efficacy of antiepileptic drugs in children and adolescents: A network meta-analysis. ( Crescioli, G; De Masi, S; Guerrini, R; Ilvento, L; Lucenteforte, E; McGreevy, KS; Mugelli, A; Pugi, A; Rosati, A; Virgili, G, 2018) |
| " We report an infant with SCAD deficiency who unexpectedly exhibited an extremely high blood concentration of valproic acid (VPA) and agranulocytosis." | 4.02 | Unexpected elevation in valproic acid concentration and agranulocytosis in a patient with short-chain acyl-CoA dehydrogenase deficiency. ( Eto, K; Hara, K; Ito, S; Nagata, S; Nishikawa, A; Oguni, H; Otani, Y; Suzuki, Y, 2021) |
| " At day 58 after birth, oral high-dose phenobarbital therapy was introduced which resulted in the suppression of seizures to one or two per week and disappearance of the burst-suppression pattern on EEG." | 3.91 | A case of early myoclonic encephalopathy with intractable seizures successfully treated with high-dose phenobarbital. ( Kawatani, M; Kometani, H; Kosaka, T; Ohshima, Y; Ohta, G, 2019) |
| " Seizures were controlled in a few weeks with intramuscular synthetic ACTH, followed by valproic acid." | 3.81 | LAMA2-related congenital muscular dystrophy complicated by West syndrome. ( Camacho, A; de Aragón, AM; Dekomien, G; Hernández-Laín, A; Núñez, N; Simón, R, 2015) |
| " The aim of our study was to analyze the effect of age, gender, daily RUF dose per body weight (mg/kg), valproic acid (VPA), and enzyme-inducing antiepileptic drugs (EIAEDs) on RUF concentration-to-dose ratio (RUF serum concentration/RUF dose per body weight), RUF clearance (RUF dose/RUF serum concentration), and RUF trough concentrations." | 3.77 | Serum concentrations of rufinamide in children and adults with epilepsy: the influence of dose, age, and comedication. ( Boor, R; Brandt, C; Jürgens, U; Korn-Merker, E; May, TW; Rambeck, B, 2011) |
| "To review the result of the infantile spasms' treatment with sodium valproate followed by nitrazepam or clonazepam." | 3.74 | Treatment of infantile spasms with sodium valproate followed by benzodiazepines. ( Auvichayapat, N; Auvichayapat, P; Tassniyom, S; Treerotphon, S, 2007) |
| " The effects of systemic pretreatment with hydrocortisone (5-25 mg/kg), pyridoxine (20-250 mg/kg), and sodium valproate (VPA; 200 and 400 mg/kg) against the NMDA-induced automatisms, emprosthotonic (hyperflexion), and clonic-tonic seizures were determined." | 3.70 | Age-specific N-methyl-D-aspartate-induced seizures: perspectives for the West syndrome model. ( Kábová, R; Liptáková, S; Pometlová, M; Slamberová, R; Velísek, L, 1999) |
| " The mainstay of treatment is with multiple anti-seizure medications (ASMs); however, the ASMs themselves can be associated with psychobehavioural adverse events, and effects (negative or positive) on cognition and sleep." | 2.82 | Psychobehavioural and Cognitive Adverse Events of Anti-Seizure Medications for the Treatment of Developmental and Epileptic Encephalopathies. ( Schubert-Bast, S; Strzelczyk, A, 2022) |
| " It included (1) the drugs used for the treatment, (2) their dosage, and (3) the dosage and the schedule of adrenocorticotropic hormone therapy." | 2.73 | Current treatment of West syndrome in Japan. ( Ito, M; Okumura, A; Ozawa, H; Tsuji, T; Watanabe, K, 2007) |
| "Twenty patients with West syndrome were initially treated with high-dose vitamin B6 (40 to 50 mg/kg/day) and valproate (40 to 50 mg/kg/day)." | 2.70 | [Seizure and developmental prognosis of West syndrome--combination therapy with high-dose vitamin B6, valproate and low-dose ACTH]. ( Fujii, T; Ito, M; Miyajima, T; Okuno, T, 2001) |
| "West syndrome is a generalized epilepsy syndrome composed of infantile spasms and onset is usually within the first year of life." | 2.44 | Update of the medical treatment of West syndrome. ( Chiarelli, F; Coppola, GG; Iannetti, P; Manco, R; Mingione, S; Verrotti, A, 2007) |
| "Adrenocorticotropic hormone (ACTH) is probably effective for the short-term treatment of infantile spasms, but there is insufficient evidence to recommend the optimum dosage and duration of treatment." | 2.42 | Practice parameter: medical treatment of infantile spasms: report of the American Academy of Neurology and the Child Neurology Society. ( Adams-Webber, T; Ashwal, S; Ballaban-Gill, K; Baram, TZ; Duchowny, M; Hirtz, D; Mackay, MT; Pellock, JM; Shields, WD; Shinnar, S; Snead, OC; Stephens, D; Weiss, SK; Wyllie, E, 2004) |
| "Carnitine was strongly recommended for children at risk of developing a carnitine deficiency." | 2.41 | The role of carnitine supplementation during valproic acid therapy. ( El-Chaar, GM; Raskind, JY, 2000) |
| "Data from published research were extracted and evaluated according to study design, sample size, dosing regimen, outcome measures, and treatment efficacy and safety." | 2.39 | Treatment of infantile spasms. ( Casto, DT; Haines, ST, 1994) |
| "The underlying diseases included intracranial hemorrhage, hypoxic-ischemic encephalopathy, tuberous sclerosis, and cerebral infarction." | 1.72 | Blood coagulation dynamics during adrenocorticotropic hormone therapy in pediatric patients with infantile spasms. ( Nogami, K; Ogiwara, K; Sakakibara, T; Takeda, Y, 2022) |
| "Fenfluramine (FFA), an antiseizure medication (ASM) indicated for treating convulsive seizures in Dravet syndrome, was assessed in six patients (five female; 83%) with CDD whose seizures had failed 5-12 ASMs or therapies." | 1.62 | Effect of fenfluramine on convulsive seizures in CDKL5 deficiency disorder. ( Conway, E; Devinsky, O; King, L; Price, D; Schwartz, D, 2021) |
| "The intractable seizures showed complete but transient responsiveness to pyridoxal phosphate and finally controlled by valproate treatment." | 1.51 | ARX-associated infantile epileptic-dyskinetic encephalopathy with responsiveness to valproate for controlling seizures and reduced activity of muscle mitochondrial complex IV. ( Chu, VL; Fung, CW; Kwong, AK; Rodenburg, RJT; Smeitink, J, 2019) |
| "However, seizures are not typical and the majority of them were seizure-free." | 1.51 | A 16q22.2-q23.1 deletion identified in a male infant with West syndrome. ( Goji, A; Imoto, I; Ito, H; Kagami, S; Kohmoto, T; Mori, K; Mori, T; Toda, Y, 2019) |
| "Vigabatrin was used by 29 children (94%), and was first treatment in 15 (48%)." | 1.42 | Epilepsy in children with tuberous sclerosis complex: Chance of remission and response to antiepileptic drugs. ( Bindels-de Heus, K; de Wit, MC; Moll, HA; Overwater, IE; Rietman, AB; Ten Hoopen, LW; Vergouwe, Y, 2015) |
| "EEG was suggestive of hypsarrhythmia." | 1.40 | Encephalopathy in an infant with infantile spasms: possible role of valproate toxicity. ( Sampath, S; Sivathanu, S; Sunderkumar, S; Veerasamy, M, 2014) |
| "West syndrome is an age-dependent epileptic syndrome related to a group of infantile epileptic encephalopathies and characterized by a triad of basic symptoms: series of infantile spasms, psychomotor retardation and severe paroxysmal EEG changes." | 1.40 | [Case of combination of Beckwith-Wiedemann syndrome with West syndrome]. ( Globa, OV; Kremenchugskaya, MR; Kuzenkova, LM; Podkletnova, TV, 2014) |
| "Although most patients with infantile Alexander disease have epilepsy, infantile spasms are rare." | 1.39 | Alexander disease with mild dorsal brainstem atrophy and infantile spasms. ( Hara, T; Ishizaki, Y; Sanefuji, M; Sawaishi, Y; Torisu, H; Yamaguchi-Takada, Y; Yano, T; Yoshikawa, Y, 2013) |
| "A transformation of hypsarrhythmia was observed as the patients grew older." | 1.38 | [Age-related transformation of infantile spasms into drug-resistant forms of epilepsy]. ( Volkov, IV; Volkova, OK, 2012) |
| "Early myoclonic encephalopathy usually starts in the first month of life." | 1.38 | [The clinical and electroencephalographic characteristics of early myoclonic encephalopathy]. ( Huang, R; Li, B; Liu, CT; Yin, F, 2012) |
| "On VPA 1000 mg/d, the seizure frequency decreased significantly." | 1.37 | Valproate treatment after liver transplant in a patient with Lennox-Gastaut syndrome. ( Crespel, A; Gelisse, P; Genton, P; Pageaux, GP; Velizarova, R, 2011) |
| "Clonic seizures were rare in NMDA-treated P25 rats, but valproate pretreatment increased their incidence significantly." | 1.36 | Vigabatrin but not valproate prevents development of age-specific flexion seizures induced by N-methyl-D-aspartate (NMDA) in immature rats. ( Kubová, H; Mares, P, 2010) |
| "Children with West syndrome have better seizure control and development, if the treatment is started within 1 month of onset of symptoms." | 1.35 | Outcome in West syndrome. ( Sharma, NL; Vishwanthan, V, 2008) |
| "Children with Down syndrome are highly susceptible to infantile spasms." | 1.35 | Infantile spasms and Down syndrome: a new animal model. ( Aleem, IS; Ashraf, A; Cortez, MA; Kanawaty, A; Liu, CC; Sadeghnia, HR; Shen, L; Snead, OC; Stewart, L; Trepanier, CH; Wu, Y, 2009) |
| "We diagnosed interstitial pneumonitis (IP) based on her chest CT and high serum concentrations of KL-6 and surfactant protein D." | 1.34 | [Valproate sodium and zonisamide associated interstitial pneumonitis in an infant]. ( Doi, T; Kato, T; Nikaido, K; Takayama, R, 2007) |
| "Three patients with dysfibrinogenemia or fibrinogen deficiency showed normal or slightly prolonged PT values and normal APTT values." | 1.34 | [Analysis of hypofibrinogenemias found on routine coagulation screening tests and identification of heterozygous dysfibrinogenemia or fibrinogen deficiency]. ( Fujihara, N; Hirota-Kawadobora, M; Ishikawa, S; Kamijo, Y; Katsuyama, T; Okumura, N; Terasawa, F; Wakabayashi, S; Yamauchi, K, 2007) |
| "The course of epilepsy is more difficult to predict, but failure to respond to the first AED is worrisome." | 1.31 | Prognosis of seizures occurring in the first year. ( Datta, AN; Wirrell, EC, 2000) |
| "The treatment of West syndrome is not well established at present and further research is needed to improve the therapeutic protocol." | 1.31 | Current therapy for West syndrome in Japan. ( Ito, M; Seki, T; Takuma, Y, 2000) |
| "A 6-month-old girl developed West syndrome and it remitted in association with valproate-induced hepatic dysfunction." | 1.31 | Remission of West syndrome associated with valproate hepatotoxicity. ( Go, T, 2002) |
| "Total remission of seizures occurred in 52%." | 1.30 | Long-term outcomes of conventional therapy for infantile spasms. ( Clarke, SL; Griesemer, DA; Holden, KR, 1997) |
| "EEG showed typical hypsarrhythmia in 8 cases, asymmetrical hypsarrhythmia in 1 case and modified hypsarrhythmia in another case." | 1.30 | [West's syndrome in patients with cerebral paralysis and periventricular leukomalacia: a good response to treatment]. ( Caraballo, R; Cersósimo, R; Fejerman, N; Intruvini, S; Pociecha, J, 1997) |
| " The most frequently used dosage was 40 IU per day, and the most frequent duration of treatment was 1 to 2 months." | 1.29 | The treatment of infantile spasms by child neurologists. ( Bobele, GB; Bodensteiner, JB, 1994) |
| "Nitrazepam is an effective anticonvulsant in this small cohort of children with medically refractory infantile spasms and the Lennox-Gastaut syndrome, resulting in a 25% response rate and only modest side effects." | 1.29 | Nitrazepam for refractory infantile spasms and the Lennox-Gastaut syndrome. ( Chamberlain, MC, 1996) |
| "West syndrome is a peculiar form of epilepsy of infancy and childhood characterized by spasms or massive myoclonus, regression neuropsychomotor development, and EEG abnormalities referred as hipsarrhythmia." | 1.29 | [West syndrome: apropos of 9 cases]. ( Kamiyama, MA; Tonholo-Silva, ER; Yoshinaga, L, 1993) |
| "A 3-year-old boy with West syndrome who was shown to have a cystic lesion on magnetic resonance imagings underwent surgical treatment." | 1.29 | West syndrome associated with porencephaly. ( Aihara, N; Ishikawa, T; Kamiya, K; Kanayama, M; Katano, H; Nagai, H; Yamashita, N, 1994) |
| "In contrast, cryptogenic infantile spasms, in which there is no identifiable brain lesion, usually run a favorable course under treatment." | 1.28 | [A prognostic study of cryptogenic infantile spasms]. ( Boulloche, J; Dautreme, P; Le Luyer, B; Mallet, E; Tron, P, 1991) |
| "Recurrence of hypsarrhythmia was observed most often in patients treated with doses lower than 200mg/kg/day." | 1.28 | Infantile spasms treated with high doses of sodium valproate: initial response and follow-up. ( Garaizar, C; Garcia-Nieto, ML; Madoz, P; Prats, JM; Rua, MJ, 1991) |
| " Children can begin to receive valproate treatment in a dosage of 20 to 30 mg/kg per day in two or three divided doses." | 1.27 | Valproate monotherapy in children. ( Murphy, JV, 1988) |
| "The bioavailability of commercially available valproic acid (VPA) syrup was studied following rectal administration in both dogs and children." | 1.26 | Bioavailability of rectally administered valproic acid syrup. ( Cloyd, JC; Kriel, RL, 1981) |
| "Eighteen infants with infantile spasms were given sodium dipropylacetate at a dosage of 20mg/kg/day." | 1.26 | Treatment of infantile spasms with sodium dipropylacetic acid. ( Incorpora, G; La Rosa, M; Li Volti, S; Mollica, F; Pavone, L, 1981) |
| " The following results were found while DPA was administered in a relatively high dosage with a mean of 48 mg/kg body weight/day and ranging from 7 to 125 mg/kg/day." | 1.26 | Treatment of childhood epilepsy with dipropylacetic acid (DPA). ( Blaschke, E; Fehr, R; Lagenstein, I; Rothe, M; Sternowsky, HJ, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (18.28) | 18.7374 |
| 1990's | 27 (29.03) | 18.2507 |
| 2000's | 21 (22.58) | 29.6817 |
| 2010's | 22 (23.66) | 24.3611 |
| 2020's | 6 (6.45) | 2.80 |
| Authors | Studies |
|---|---|
| Takeda, Y | 1 |
| Sakakibara, T | 1 |
| Ogiwara, K | 1 |
| Nogami, K | 1 |
| Ju, Y | 1 |
| Ji, TY | 1 |
| Strzelczyk, A | 1 |
| Schubert-Bast, S | 1 |
| Alsallumi, MS | 1 |
| Kopel, J | 1 |
| Grooms, A | 1 |
| Ganapathy, V | 1 |
| Clothier, J | 1 |
| Suzuki, Y | 2 |
| Ito, S | 1 |
| Otani, Y | 1 |
| Nishikawa, A | 1 |
| Eto, K | 1 |
| Hara, K | 1 |
| Oguni, H | 1 |
| Nagata, S | 1 |
| Devinsky, O | 1 |
| King, L | 1 |
| Schwartz, D | 1 |
| Conway, E | 1 |
| Price, D | 1 |
| Rosati, A | 1 |
| Ilvento, L | 1 |
| Lucenteforte, E | 1 |
| Pugi, A | 1 |
| Crescioli, G | 1 |
| McGreevy, KS | 1 |
| Virgili, G | 1 |
| Mugelli, A | 1 |
| De Masi, S | 1 |
| Guerrini, R | 1 |
| Kosaka, T | 1 |
| Ohta, G | 1 |
| Kometani, H | 1 |
| Kawatani, M | 1 |
| Ohshima, Y | 1 |
| Kwong, AK | 1 |
| Chu, VL | 1 |
| Rodenburg, RJT | 1 |
| Smeitink, J | 1 |
| Fung, CW | 1 |
| Mori, T | 1 |
| Goji, A | 1 |
| Toda, Y | 1 |
| Ito, H | 1 |
| Mori, K | 1 |
| Kohmoto, T | 1 |
| Imoto, I | 1 |
| Kagami, S | 1 |
| Ennaim, N | 1 |
| Bourrous, M | 1 |
| Rada, N | 1 |
| Draiss, G | 1 |
| Bouskraoui, M | 1 |
| Patil, RB | 1 |
| Urs, P | 1 |
| Kiran, S | 1 |
| Bargale, SD | 1 |
| Sivathanu, S | 1 |
| Sampath, S | 1 |
| Veerasamy, M | 1 |
| Sunderkumar, S | 1 |
| Camacho, A | 1 |
| Núñez, N | 1 |
| Dekomien, G | 1 |
| Hernández-Laín, A | 1 |
| de Aragón, AM | 1 |
| Simón, R | 1 |
| Kuzenkova, LM | 1 |
| Kremenchugskaya, MR | 1 |
| Globa, OV | 1 |
| Podkletnova, TV | 1 |
| Overwater, IE | 1 |
| Bindels-de Heus, K | 1 |
| Rietman, AB | 1 |
| Ten Hoopen, LW | 1 |
| Vergouwe, Y | 1 |
| Moll, HA | 1 |
| de Wit, MC | 1 |
| Deng, XL | 1 |
| Yin, F | 2 |
| Zhang, CL | 1 |
| Ma, YP | 1 |
| He, F | 1 |
| Wu, LW | 1 |
| Peng, J | 1 |
| Sharma, NL | 1 |
| Vishwanthan, V | 1 |
| Cortez, MA | 1 |
| Shen, L | 1 |
| Wu, Y | 1 |
| Aleem, IS | 1 |
| Trepanier, CH | 1 |
| Sadeghnia, HR | 1 |
| Ashraf, A | 1 |
| Kanawaty, A | 1 |
| Liu, CC | 1 |
| Stewart, L | 1 |
| Snead, OC | 2 |
| Kubová, H | 1 |
| Mares, P | 1 |
| Lagae, L | 1 |
| Verhelst, H | 1 |
| Ceulemans, B | 1 |
| De Meirleir, L | 1 |
| Nassogne, MC | 1 |
| De Borchgrave, V | 1 |
| D'Hooghe, M | 1 |
| Foulon, M | 1 |
| Van Bogaert, P | 1 |
| Coppola, G | 1 |
| Grosso, S | 1 |
| Franzoni, E | 1 |
| Veggiotti, P | 1 |
| Zamponi, N | 1 |
| Parisi, P | 1 |
| Spalice, A | 1 |
| Habetswallner, F | 1 |
| Fels, A | 1 |
| Capovilla, G | 1 |
| Verrotti, A | 2 |
| Mangano, S | 1 |
| Balestri, A | 1 |
| Curatolo, P | 1 |
| Pascotto, A | 1 |
| Navas-Sánchez, P | 1 |
| Martínez-Antón, J | 1 |
| Bauzano-Poley, E | 1 |
| Velizarova, R | 1 |
| Gelisse, P | 1 |
| Pageaux, GP | 1 |
| Genton, P | 1 |
| Crespel, A | 1 |
| May, TW | 1 |
| Boor, R | 1 |
| Rambeck, B | 1 |
| Jürgens, U | 1 |
| Korn-Merker, E | 1 |
| Brandt, C | 1 |
| Meyer, S | 1 |
| Martin, T | 1 |
| Löffler, G | 1 |
| Gortner, L | 1 |
| Torisu, H | 1 |
| Yoshikawa, Y | 1 |
| Yamaguchi-Takada, Y | 1 |
| Yano, T | 1 |
| Sanefuji, M | 1 |
| Ishizaki, Y | 1 |
| Sawaishi, Y | 1 |
| Hara, T | 1 |
| Liu, CT | 1 |
| Huang, R | 1 |
| Li, B | 1 |
| Volkov, IV | 1 |
| Volkova, OK | 1 |
| Ohtahara, S | 2 |
| Tein, I | 1 |
| Mackay, MT | 1 |
| Weiss, SK | 1 |
| Adams-Webber, T | 1 |
| Ashwal, S | 1 |
| Stephens, D | 1 |
| Ballaban-Gill, K | 1 |
| Baram, TZ | 1 |
| Duchowny, M | 1 |
| Hirtz, D | 1 |
| Pellock, JM | 1 |
| Shields, WD | 1 |
| Shinnar, S | 1 |
| Wyllie, E | 1 |
| Lapatsanis, P | 1 |
| Lapatsanis, D | 1 |
| Nikaido, K | 1 |
| Kato, T | 1 |
| Takayama, R | 1 |
| Doi, T | 1 |
| Manco, R | 1 |
| Coppola, GG | 1 |
| Mingione, S | 1 |
| Chiarelli, F | 1 |
| Iannetti, P | 1 |
| Tsuji, T | 1 |
| Okumura, A | 1 |
| Ozawa, H | 1 |
| Ito, M | 4 |
| Watanabe, K | 1 |
| Yamamoto, H | 1 |
| Fukuda, M | 1 |
| Murakami, H | 1 |
| Kamiyama, N | 1 |
| Miyamoto, Y | 1 |
| Auvichayapat, N | 1 |
| Tassniyom, S | 1 |
| Treerotphon, S | 1 |
| Auvichayapat, P | 1 |
| Visudhiphan, P | 1 |
| Hirota-Kawadobora, M | 1 |
| Ishikawa, S | 1 |
| Fujihara, N | 1 |
| Wakabayashi, S | 1 |
| Kamijo, Y | 1 |
| Yamauchi, K | 1 |
| Terasawa, F | 1 |
| Okumura, N | 1 |
| Katsuyama, T | 1 |
| Kiul'ts, I | 1 |
| Klaĭf, F | 1 |
| Pavone, L | 1 |
| Incorpora, G | 1 |
| La Rosa, M | 1 |
| Li Volti, S | 1 |
| Mollica, F | 1 |
| Bachman, DS | 1 |
| Ramsay, RE | 1 |
| Maheshwari, MC | 1 |
| Cloyd, JC | 1 |
| Kriel, RL | 1 |
| Badalian, LO | 1 |
| Temin, PA | 1 |
| Medvedev, MI | 1 |
| Mukhin, KIu | 1 |
| Iskander, MB | 1 |
| Kharlamov, DA | 1 |
| Veselov, NK | 1 |
| Katano, H | 1 |
| Nagai, H | 1 |
| Aihara, N | 1 |
| Yamashita, N | 1 |
| Kamiya, K | 1 |
| Ishikawa, T | 1 |
| Kanayama, M | 1 |
| Konishi, T | 1 |
| Naganuma, Y | 1 |
| Hongo, K | 1 |
| Murakami, M | 1 |
| Yagi, S | 1 |
| Yamatani, M | 1 |
| Okada, T | 1 |
| Bobele, GB | 1 |
| Bodensteiner, JB | 1 |
| Haines, ST | 1 |
| Casto, DT | 1 |
| Schlumberger, E | 1 |
| Dulac, O | 2 |
| Kamiyama, MA | 1 |
| Yoshinaga, L | 1 |
| Tonholo-Silva, ER | 1 |
| Appleton, RE | 1 |
| Kuwahara, M | 1 |
| Shima, M | 1 |
| Nakai, H | 1 |
| Nishino, M | 1 |
| Fukuzumi, A | 1 |
| Yoshioka, A | 1 |
| Chamberlain, MC | 1 |
| Kita, T | 1 |
| Mano, T | 1 |
| Arai, H | 1 |
| Matsuoka, T | 1 |
| Kodaka, R | 1 |
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| Nagai, T | 1 |
| Okada, S | 1 |
| Prats-Viñas, JM | 1 |
| Garaizar-Axpe, C | 1 |
| Taniguchi, Y | 1 |
| Hattori, H | 1 |
| Higuchi, Y | 1 |
| Maihara, T | 1 |
| Jung, EY | 1 |
| Furusho, K | 1 |
| Seki, T | 2 |
| Holden, KR | 1 |
| Clarke, SL | 1 |
| Griesemer, DA | 1 |
| Caraballo, R | 1 |
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| Gaily, E | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Fenfluramine in CKDL5 Deficiency Disorder (CDD)[NCT03861871] | Phase 2 | 7 participants (Actual) | Interventional | 2019-10-29 | Completed | ||
| Efficacy of Vigabatrin With High Dose Prednisolone Combination Therapy Versus Vigabatrin Alone for Infantile Spasm: a Randomized Trial[NCT04302116] | 250 participants (Anticipated) | Interventional | 2020-05-18 | Recruiting | |||
| Prednisolone vs. Vigabatrin in the First-line Treatment of Infantile Spasms[NCT02299115] | Phase 3 | 0 participants (Actual) | Interventional | 2017-09-05 | Withdrawn (stopped due to Most centres are now using oral steroids as 1st line treatment so question of efficacy is no longer of high interest.) | ||
| ADRENL - ACTHAR Gel for Drug REsistant Nephrotic Syndrome in Children, Pilot Study[NCT03408405] | Phase 4 | 0 participants (Actual) | Interventional | 2018-06-30 | Withdrawn (stopped due to Withdrawal of funding from primary sponsor) | ||
| Evaluating the Impact of Supplementing Residential Substance Use Treatment With Written Exposure Therapy for Veterans With Co-Occurring PTSD and Substance Use Disorders[NCT05536908] | 50 participants (Anticipated) | Interventional | 2023-06-22 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Change between baseline and Week 14 in the median number of monthly convulsive seizures. (NCT03861871)
Timeframe: Baseline, Week 14
| Intervention | Number of monthly seizures (Median) |
|---|---|
| Fenfluramine Hydrochloride | 88.429 |
The CGIC is a 1-item, parent/caregiver-completed assessment used determine how much their child/care-recipient has improved with treatment. The instrument asks parents/caregivers to rate their child's/care-recipient's improvement as: 1) very much improved; 2) much improved; 3) minimally improved; 4) unchanged; 5) a little worse; 6) much worse; 7) very much worse; the total score correspondingly ranges from 1-7. (NCT03861871)
Timeframe: Baseline, Week 14
| Intervention | score on a scale (Mean) |
|---|---|
| Fenfluramine Hydrochloride | -2.429 |
The IGIC is a 1-item, investigator-completed assessment used determine how much a patient has improved with treatment. The instrument asks the investigator to rate patients' improvement as: 1) very much improved; 2) much improved; 3) minimally improved; 4) unchanged; 5) a little worse; 6) much worse; 7) very much worse; the total score correspondingly ranges from 1-7. (NCT03861871)
Timeframe: Baseline, Week 14
| Intervention | score on a scale (Mean) |
|---|---|
| Fenfluramine Hydrochloride | 1.571 |
The PedsQL Epilepsy Module is a 29-item measure with five scales: Impact, Cognitive, Sleep, Executive Function, and Mood/Behavior. The Impact scale (nine items) assesses how epilepsy interferes with daily activities, interacting with peers, independence, and increased disease burden due to treatment. The Cognitive Scale (six items) assesses memory, ability to learn new materials, school-related difficulties, and reading difficulties. The Sleep Scale (three items) assesses fatigue and sleep difficulties. The Executive Function Scale (six items) assesses organization, task initiation, impulsivity, and inattention. The Mood/Behavior Scale (five items) assesses feelings of anger, sadness, worries, and frustration tolerance. Scores range from 0-100 for each subscale, with higher scores representing better quality of life. The raw score is the sum of each subscale score and ranges from 0-500. (NCT03861871)
Timeframe: Baseline, Week 14
| Intervention | score on a scale (Mean) |
|---|---|
| Fenfluramine Hydrochloride | -103.571 |
Parent/caregiver-completed assessment assessing how epilepsy affects day-to-day functioning of their child/care-recipient in various life areas. Each item is ranked on a 5-point Likert scale from 1 (response correlated with the lowest possible quality of life) to 5 (response correlated with the highest possible quality of life). Item scores are then transformed to a 0-100 scale as follows: 1 = 0, 2 = 25, 3 = 50, 4=75, and 5=100. The total score is the average of all item scores and ranges from 0-100. Higher scores indicate greater quality of life; an increase in scores indicates quality of life increased during the observational period. (NCT03861871)
Timeframe: Baseline, Week 14
| Intervention | score on a scale (Mean) |
|---|---|
| Fenfluramine Hydrochloride | -0.429 |
13 reviews available for valproic acid and Spasms, Infantile
| Article | Year |
|---|---|
Psychobehavioural and Cognitive Adverse Events of Anti-Seizure Medications for the Treatment of Developmental and Epileptic Encephalopathies.
Topics: Autism Spectrum Disorder; Bromides; Cannabidiol; Clobazam; Cognition; Ethosuximide; Everolimus; Felb | 2022 |
Comparative efficacy of antiepileptic drugs in children and adolescents: A network meta-analysis.
Topics: Adolescent; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Carbamazepine; Ch | 2018 |
[Dynamin-1-related infantile spasms: a case report and review of literature].
Topics: Child; Child, Preschool; Developmental Disabilities; Dynamin I; Electroencephalography; Epilepsy; Fe | 2016 |
[West syndrome(infantile spasms)].
Topics: Cosyntropin; Diagnosis, Differential; Electroencephalography; Humans; Infant; Infant, Newborn; Progn | 2002 |
Role of carnitine and fatty acid oxidation and its defects in infantile epilepsy.
Topics: Acyl-CoA Dehydrogenase; Anticonvulsants; Carnitine; Carrier Proteins; Chemical and Drug Induced Live | 2002 |
Practice parameter: medical treatment of infantile spasms: report of the American Academy of Neurology and the Child Neurology Society.
Topics: Administration, Oral; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Child, | 2004 |
Practice parameter: medical treatment of infantile spasms: report of the American Academy of Neurology and the Child Neurology Society.
Topics: Administration, Oral; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Child, | 2004 |
Practice parameter: medical treatment of infantile spasms: report of the American Academy of Neurology and the Child Neurology Society.
Topics: Administration, Oral; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Child, | 2004 |
Practice parameter: medical treatment of infantile spasms: report of the American Academy of Neurology and the Child Neurology Society.
Topics: Administration, Oral; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Child, | 2004 |
Practice parameter: medical treatment of infantile spasms: report of the American Academy of Neurology and the Child Neurology Society.
Topics: Administration, Oral; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Child, | 2004 |
Practice parameter: medical treatment of infantile spasms: report of the American Academy of Neurology and the Child Neurology Society.
Topics: Administration, Oral; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Child, | 2004 |
Practice parameter: medical treatment of infantile spasms: report of the American Academy of Neurology and the Child Neurology Society.
Topics: Administration, Oral; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Child, | 2004 |
Practice parameter: medical treatment of infantile spasms: report of the American Academy of Neurology and the Child Neurology Society.
Topics: Administration, Oral; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Child, | 2004 |
Practice parameter: medical treatment of infantile spasms: report of the American Academy of Neurology and the Child Neurology Society.
Topics: Administration, Oral; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Child, | 2004 |
Update of the medical treatment of West syndrome.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Drug Therapy, Combination; Electroencephalography; Glu | 2007 |
Treatment of infantile spasms.
Topics: 4-Aminobutyrate Transaminase; Adrenocorticotropic Hormone; Anticonvulsants; Benzodiazepines; gamma-A | 1994 |
[Infantile spasms (West's syndrome): characteristics and therapeutic options].
Topics: Adrenocorticotropic Hormone; Electroencephalography; Humans; Infant; Spasms, Infantile; Valproic Aci | 1996 |
[Treatment of West syndrome: present and future perspectives].
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Humans; Infant; Pilot Projects; Pyridoxal Phosphate; S | 1997 |
The role of carnitine supplementation during valproic acid therapy.
Topics: Adolescent; Adult; Aged; Ammonia; Anticonvulsants; Carnitine; Chemical and Drug Induced Liver Injury | 2000 |
Valproate: an updated review.
Topics: Abnormalities, Drug-Induced; Brain Diseases; Chemical and Drug Induced Liver Injury; Coma; Dyskinesi | 1985 |
Myoclonus.
Topics: Adrenocorticotropic Hormone; Child; Child, Preschool; Clonazepam; Diagnosis, Differential; Electroen | 1985 |
11 trials available for valproic acid and Spasms, Infantile
| Article | Year |
|---|---|
Rufinamide in children and adults with Lennox-Gastaut syndrome: first Italian multicenter experience.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Female; Huma | 2010 |
Current treatment of West syndrome in Japan.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Dose-Response Relationship, Drug; Drug Administration | 2007 |
Controlled and comparative trials with valproate: United States.
Topics: Adolescent; Adult; Child; Child, Preschool; Clinical Trials as Topic; Epilepsy; Epilepsy, Absence; E | 1984 |
[The enkorat treatment of infantile spasms and the Lennox-Gastaut syndrome].
Topics: Anticonvulsants; Carbamazepine; Child, Preschool; Clonazepam; Drug Therapy, Combination; Epilepsy; E | 1994 |
A simple, effective and well-tolerated treatment regime for West syndrome.
Topics: Cosyntropin; Drug Administration Schedule; Drug Therapy, Combination; Humans; Hydrocortisone; Infant | 1994 |
[Outcome of initial treatment with high-dose vitamin B6, valproate sodium or clonazepam in West syndrome].
Topics: Anticonvulsants; Child; Child, Preschool; Clonazepam; Female; Humans; Infant; Male; Pyridoxine; Spas | 1996 |
Long-term follow-up study of vigabatrin in pretreated children with West syndrome.
Topics: Adrenocorticotropic Hormone; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Child, Preschool | 1998 |
Treatment of infantile spasms: results of a population-based study with vigabatrin as the first drug for spasms.
Topics: 4-Aminobutyrate Transaminase; Adrenocorticotropic Hormone; Anticonvulsants; Brain Diseases; Child; C | 1999 |
[West syndrome: clinical and electroencephalographic follow up of 70 patients and response to its treatment with adrenocorticotropic hormone, prednisone, vigabatrin, nitrazepam and valproate].
Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Anticonvulsants; Child; Child, Preschool; Electroenc | 2000 |
[Seizure and developmental prognosis of West syndrome--combination therapy with high-dose vitamin B6, valproate and low-dose ACTH].
Topics: Adrenocorticotropic Hormone; Child; Child, Preschool; Developmental Disabilities; Drug Administratio | 2001 |
[Experiences with sodium 2-propyl valerate (Depakine) in the treatment of epilepsy].
Topics: Adolescent; Adult; Aged; Carbamazepine; Cerebrospinal Fluid Shunts; Child; Child, Preschool; Clinica | 1977 |
69 other studies available for valproic acid and Spasms, Infantile
| Article | Year |
|---|---|
Blood coagulation dynamics during adrenocorticotropic hormone therapy in pediatric patients with infantile spasms.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Blood Coagulation; Female; Humans; Infant; Intracrania | 2022 |
[Clinical features of epilepsy in 5 children with Mowat-Wilson syndrome].
Topics: Child; Electroencephalography; Epilepsy; Facies; Female; Hirschsprung Disease; Humans; Intellectual | 2022 |
Hypsarrhythmia and spasms resolution after Valproic acid discontinuation in an infantile spasm patient.
Topics: Anticonvulsants; Drug Administration Schedule; Female; Humans; Infant; Spasms, Infantile; Thrombocyt | 2019 |
Metformin, valproic acid, and starvation induce seizures in a patient with partial SLC13A5 deficiency: a case of pharmaco-synergistic heterozygosity.
Topics: Adult; Amino Acid Substitution; Ammonia; Animals; Anticonvulsants; Autistic Disorder; Bipolar Disord | 2021 |
Unexpected elevation in valproic acid concentration and agranulocytosis in a patient with short-chain acyl-CoA dehydrogenase deficiency.
Topics: Acyl-CoA Dehydrogenase; Agranulocytosis; Anticonvulsants; Female; Humans; Infant; Lipid Metabolism, | 2021 |
Effect of fenfluramine on convulsive seizures in CDKL5 deficiency disorder.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Epilepsies, Myoclonic; Epilepsy, Tonic- | 2021 |
A case of early myoclonic encephalopathy with intractable seizures successfully treated with high-dose phenobarbital.
Topics: Anticonvulsants; Electroencephalography; Epilepsies, Myoclonic; Humans; Infant; Male; Phenobarbital; | 2019 |
ARX-associated infantile epileptic-dyskinetic encephalopathy with responsiveness to valproate for controlling seizures and reduced activity of muscle mitochondrial complex IV.
Topics: Adolescent; Adult; Asian People; China; Cytochrome-c Oxidase Deficiency; Dystonic Disorders; Epileps | 2019 |
A 16q22.2-q23.1 deletion identified in a male infant with West syndrome.
Topics: Anticonvulsants; Chromosomes, Human, Pair 16; Epilepsy; Humans; Infant; Intellectual Disability; Lam | 2019 |
[Lennox-Gastaut syndrome: Experience of Marrakech University Hospital].
Topics: Accidental Falls; Anticonvulsants; Asphyxia Neonatorum; Atrophy; Cerebral Cortex; Child; Child, Pres | 2013 |
Global developmental delay with sodium valproate-induced gingival hyperplasia.
Topics: Child; Child, Preschool; Combined Modality Therapy; Developmental Disabilities; Female; Follow-Up St | 2014 |
Encephalopathy in an infant with infantile spasms: possible role of valproate toxicity.
Topics: Adrenocorticotropic Hormone; Ammonia; Anticonvulsants; Clonazepam; Drug Therapy, Combination; Female | 2014 |
LAMA2-related congenital muscular dystrophy complicated by West syndrome.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Brain; Child, Preschool; Electroencephalography; Human | 2015 |
[Case of combination of Beckwith-Wiedemann syndrome with West syndrome].
Topics: Anticonvulsants; Beckwith-Wiedemann Syndrome; Child; Clonazepam; Electroencephalography; Epilepsy, G | 2014 |
Epilepsy in children with tuberous sclerosis complex: Chance of remission and response to antiepileptic drugs.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Diet, Ketogenic; Epilepsies, Partial; Epilepsy | 2015 |
Outcome in West syndrome.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Brain; Child, Preschool; Cognition Disorders; Electroe | 2008 |
Infantile spasms and Down syndrome: a new animal model.
Topics: 4-Butyrolactone; Animals; Anticonvulsants; Baclofen; Brain; Disease Models, Animal; Down Syndrome; E | 2009 |
Vigabatrin but not valproate prevents development of age-specific flexion seizures induced by N-methyl-D-aspartate (NMDA) in immature rats.
Topics: Age Factors; Animals; Animals, Newborn; Anticonvulsants; Behavior, Animal; Disease Models, Animal; E | 2010 |
Treatment and long term outcome in West syndrome: the clinical reality. A multicentre follow up study.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Developmental Disabilities; F | 2010 |
[Epileptic spasms without hypsarrhythmia. A new case report and review of the literature].
Topics: Anticonvulsants; Diagnosis, Differential; Electroencephalography; Epilepsy; Female; Humans; Infant; | 2010 |
Valproate treatment after liver transplant in a patient with Lennox-Gastaut syndrome.
Topics: Anticonvulsants; Chemical and Drug Induced Liver Injury; Electroencephalography; Female; Fructose; H | 2011 |
Serum concentrations of rufinamide in children and adults with epilepsy: the influence of dose, age, and comedication.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Body Weight; Child; Child, Preschool; Dose-Response | 2011 |
Severe rhabdomyolysis caused by valproic Acid in a neonate with seizures and chromosomal abnormalities.
Topics: Anticonvulsants; Chromosomes, Human, Pair 11; Dose-Response Relationship, Drug; Drug Therapy, Combin | 2011 |
Alexander disease with mild dorsal brainstem atrophy and infantile spasms.
Topics: Alexander Disease; Anticonvulsants; Atrophy; Brain Stem; Brain Waves; Corpus Callosum; DNA Mutationa | 2013 |
[The clinical and electroencephalographic characteristics of early myoclonic encephalopathy].
Topics: Anticonvulsants; Electroencephalography; Epilepsies, Myoclonic; Female; Humans; Infant; Infant, Newb | 2012 |
[Age-related transformation of infantile spasms into drug-resistant forms of epilepsy].
Topics: Anticonvulsants; Dexamethasone; Drug Resistance; Electroencephalography; Female; Humans; Infant; Mal | 2012 |
Pertussis vaccine and infantile spasms.
Topics: Adrenocorticotropic Hormone; Anti-Inflammatory Agents; Anticonvulsants; Diphtheria-Tetanus-Pertussis | 2007 |
[Valproate sodium and zonisamide associated interstitial pneumonitis in an infant].
Topics: Anticonvulsants; Epilepsy; Female; Humans; Infant; Isoxazoles; Lung Diseases, Interstitial; Respirat | 2007 |
A case of Pallister-Killian syndrome associated with West syndrome.
Topics: Anticonvulsants; Humans; Infant; Isochromosomes; Male; Mosaicism; Pyridoxal Phosphate; Spasms, Infan | 2007 |
Treatment of infantile spasms with sodium valproate followed by benzodiazepines.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Benzodiazepines; Clonazepam; Drug Therapy, Combination | 2007 |
Treatment of infantile spasms with sodium valproate followed by benzodiazepines.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Benzodiazepines; Clonazepam; Drug Therapy, Combination | 2007 |
[Analysis of hypofibrinogenemias found on routine coagulation screening tests and identification of heterozygous dysfibrinogenemia or fibrinogen deficiency].
Topics: Adrenocorticotropic Hormone; Afibrinogenemia; Asparaginase; Fibrinogen; Heterozygote; Humans; Infant | 2007 |
[Treatment of rapid nodding "salaam" spasms in childhood].
Topics: Adrenocorticotropic Hormone; Child, Preschool; Clonazepam; Electroencephalography; Female; Humans; I | 1980 |
Treatment of infantile spasms with sodium dipropylacetic acid.
Topics: Adrenocorticotropic Hormone; Child; Child, Preschool; Electroencephalography; Female; Follow-Up Stud | 1981 |
Use of valproic acid in treatment of infantile spasms.
Topics: Adrenocorticotropic Hormone; Humans; Infant; Spasms, Infantile; Valproic Acid | 1982 |
The treatable epilepsies.
Topics: Adrenocorticotropic Hormone; Child; Epilepsy; Humans; Phenytoin; Spasms, Infantile; Valproic Acid | 1983 |
Sodium valproate in the treatment of childhood epilepsies.
Topics: Child; Child, Preschool; Electroencephalography; Epilepsy; Humans; Infant; Infant, Newborn; Spasms, | 1984 |
Bioavailability of rectally administered valproic acid syrup.
Topics: Animals; Biological Availability; Dogs; Dosage Forms; Female; Humans; Infant; Kinetics; Male; Rectum | 1981 |
West syndrome associated with porencephaly.
Topics: Adrenocorticotropic Hormone; Brain Diseases; Child, Preschool; Clonazepam; Comorbidity; Cysts; Elect | 1994 |
Discontinuation of antiepileptic drug in childhood epilepsy: evaluation of the differences between epileptic syndromes.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Administration Schedule; E | 1994 |
The treatment of infantile spasms by child neurologists.
Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anticonvulsants; Dose-Response Relationship, D | 1994 |
[West syndrome: apropos of 9 cases].
Topics: Age Factors; Child; Child, Preschool; Electroencephalography; Female; Humans; Infant; Male; Neurolog | 1993 |
The treatment of infantile spasms by paediatric neurologists in the UK and Ireland.
Topics: Adrenocorticotropic Hormone; Anti-Inflammatory Agents; Anticonvulsants; gamma-Aminobutyric Acid; Hum | 1996 |
A case of West syndrome with atypical massive gray matter heterotopia that is well controlled by ACTH therapy.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Brain; Brain Diseases; Choristoma; Clonazepam; Drug Th | 1996 |
Nitrazepam for refractory infantile spasms and the Lennox-Gastaut syndrome.
Topics: Administration, Oral; Anticonvulsants; Child, Preschool; Clinical Protocols; Clinical Trials, Phase | 1996 |
[Valproate-induced pancytopenia in a patient with infantile spasms].
Topics: Anticonvulsants; Humans; Infant; Male; Pancytopenia; Spasms, Infantile; Valproic Acid | 1997 |
Long-term outcomes of conventional therapy for infantile spasms.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Cerebral Palsy; Cognition Disorders; Female; Humans; I | 1997 |
[West's syndrome in patients with cerebral paralysis and periventricular leukomalacia: a good response to treatment].
Topics: Anticonvulsants; Atrophy; Cerebral Palsy; Cerebral Ventricles; Child; Child, Preschool; Female; gamm | 1997 |
Antiepileptic drug treatment of West syndrome.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Child; Drug Administration Schedule; Drug Therapy, Com | 1998 |
Age-specific N-methyl-D-aspartate-induced seizures: perspectives for the West syndrome model.
Topics: Age Factors; Animals; Behavior, Animal; Disease Models, Animal; Electroencephalography; Humans; Hydr | 1999 |
Current therapy for West syndrome in Japan.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Child; Drug Therapy, Combination; Health Care Surveys; | 2000 |
Prognosis of seizures occurring in the first year.
Topics: Anticonvulsants; Brain; Child, Preschool; Developmental Disabilities; Diagnosis, Differential; Elect | 2000 |
[Anesthesia considerations in West syndrome].
Topics: Achilles Tendon; Anesthesia, Inhalation; Anesthetics, Inhalation; Anticonvulsants; Child; Drug Inter | 2000 |
National survey on West syndrome in Korea.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Data Collection; Female; Humans; Incidence; Infant; Ko | 2001 |
Remission of West syndrome associated with valproate hepatotoxicity.
Topics: Anticonvulsants; beta-Alanine; Chemical and Drug Induced Liver Injury; Electroencephalography; Femal | 2002 |
Treatment of childhood epilepsy with dipropylacetic acid (DPA).
Topics: Adolescent; Adult; Child; Child, Preschool; Electroencephalography; Epilepsies, Myoclonic; Epilepsy; | 1978 |
[Effectiveness of ergenyl (dipropylacetate) in hypsarrhythmia].
Topics: Child, Preschool; Electroencephalography; Humans; Infant; Spasms, Infantile; Valerates; Valproic Aci | 1976 |
[Augmented indication field for Convulex therapy (author's transl)].
Topics: Adolescent; Adult; Aged; Cerebrovascular Disorders; Child, Preschool; Electroencephalography; Enceph | 1976 |
[Infantile spasms. A retrospective study of 105 cases].
Topics: Adrenocorticotropic Hormone; Child; Child, Preschool; Electroencephalography; Evoked Potentials, Aud | 1992 |
Sixth-month benign familial convulsions.
Topics: Electroencephalography; Epilepsies, Partial; Female; Follow-Up Studies; Humans; Infant; Male; Phenob | 1992 |
[Irreversible valproate-associated liver failure].
Topics: Dandy-Walker Syndrome; Hepatic Encephalopathy; Humans; Infant; Liver; Liver Function Tests; Male; Me | 1992 |
[A prognostic study of cryptogenic infantile spasms].
Topics: Adrenocorticotropic Hormone; Child, Preschool; Cosyntropin; Developmental Disabilities; Electroencep | 1991 |
Common epileptic syndromes in children.
Topics: Adolescent; Adrenocorticotropic Hormone; Carbamazepine; Child; Child, Preschool; Electroencephalogra | 1991 |
Infantile spasms treated with high doses of sodium valproate: initial response and follow-up.
Topics: Cerebral Cortex; Child; Child, Preschool; Dose-Response Relationship, Drug; Electroencephalography; | 1991 |
High-dose sodium valproate therapy for childhood refractory epilepsy.
Topics: Adolescent; Child; Child, Preschool; Dose-Response Relationship, Drug; Electroencephalography; Epile | 1990 |
Valproate induced bleeding.
Topics: Ecchymosis; Hemorrhage; Humans; Infant; Male; Meningitis; Spasms, Infantile; Valproic Acid | 1989 |
[Benign epileptic infantile spasms].
Topics: Child, Preschool; Diazepam; Electroencephalography; Follow-Up Studies; Humans; Hydrocortisone; Infan | 1986 |
Valproate monotherapy in children.
Topics: Anticonvulsants; Child; Drug Therapy, Combination; Epilepsies, Myoclonic; Epilepsy; Epilepsy, Absenc | 1988 |
[Combination of sodium valproate and clonazepam in the treatment of symptomatic West syndrome and Lennox syndrome].
Topics: Administration, Oral; Benzodiazepinones; Child; Child, Preschool; Clonazepam; Drug Therapy, Combinat | 1985 |