valproic acid has been researched along with Somatostatinoma in 1 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Somatostatinoma: A SOMATOSTATIN-secreting tumor derived from the pancreatic delta cells (SOMATOSTATIN-SECRETING CELLS). It is also found in the INTESTINE. Somatostatinomas are associated with DIABETES MELLITUS; CHOLELITHIASIS; STEATORRHEA; and HYPOCHLORHYDRIA. The majority of somatostatinomas have the potential for METASTASIS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine the role of gamma-aminobutyric acid (GABA) in islet tissue, sodium valproate (1600 mg/day) was administered for 6 days to 10 normal subjects and 1 patient with a somatostatinoma." | 5.06 | The effects of sodium valproate on plasma somatostatin and insulin in humans. ( Fujita, S; Ichii, S; Kusunoki, M; Nakai, T; Utsunomiya, J; Yamamura, T, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kusunoki, M | 1 |
| Yamamura, T | 1 |
| Ichii, S | 1 |
| Fujita, S | 1 |
| Nakai, T | 1 |
| Utsunomiya, J | 1 |
1 trial available for valproic acid and Somatostatinoma
| Article | Year |
|---|---|
The effects of sodium valproate on plasma somatostatin and insulin in humans.
Topics: Adult; Aged; Aged, 80 and over; Blood Glucose; C-Peptide; Female; gamma-Aminobutyric Acid; Humans; I | 1988 |