valproic acid has been researched along with Small Cell Lung Carcinoma in 3 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Small Cell Lung Carcinoma: A form of highly malignant lung cancer that is composed of small ovoid cells (SMALL CELL CARCINOMA).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Lung cancer is the most frequent cause of cancer death." | 1.72 | Tumors derived from lung cancer cells respond differently to treatment with sodium valproate (a HDAC inhibitor) in a chicken embryo chorioallantoic membrane model. ( Balnytė, I; Diržiuvienė, R; Lasienė, K; Palubinskienė, J; Šlekienė, L; Stakišaitis, D; Valančiūtė, A, 2022) |
| "Among the mechanisms of resistance of small cell lung carcinomas (SCLCs) to TRAIL is the lack of caspase-8 expression." | 1.37 | Combined inhibition of DNA methyltransferase and histone deacetylase restores caspase-8 expression and sensitizes SCLC cells to TRAIL. ( Kaminskyy, VO; Surova, OV; Vaculova, A; Zhivotovsky, B, 2011) |
| "Prognosis of small cell lung carcinoma (SCLC) is particularly poor, less than 5% of patients with extensive stage being alive after two years." | 1.36 | Preclinical evidence for a beneficial impact of valproate on the response of small cell lung cancer to first-line chemotherapy. ( Albelda, SM; Burny, A; Crisanti, C; Crisanti, MC; Hubaux, R; Kapoor, V; Mascaux, C; Vandermeers, F; Willems, L, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Diržiuvienė, R | 1 |
| Šlekienė, L | 1 |
| Palubinskienė, J | 1 |
| Balnytė, I | 1 |
| Lasienė, K | 1 |
| Stakišaitis, D | 1 |
| Valančiūtė, A | 1 |
| Hubaux, R | 1 |
| Vandermeers, F | 1 |
| Crisanti, MC | 1 |
| Crisanti, C | 1 |
| Kapoor, V | 1 |
| Burny, A | 1 |
| Mascaux, C | 1 |
| Albelda, SM | 1 |
| Willems, L | 1 |
| Kaminskyy, VO | 1 |
| Surova, OV | 1 |
| Vaculova, A | 1 |
| Zhivotovsky, B | 1 |
3 other studies available for valproic acid and Small Cell Lung Carcinoma
| Article | Year |
|---|---|
Tumors derived from lung cancer cells respond differently to treatment with sodium valproate (a HDAC inhibitor) in a chicken embryo chorioallantoic membrane model.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Chick Embryo; Chickens; Chorioallantoic M | 2022 |
Preclinical evidence for a beneficial impact of valproate on the response of small cell lung cancer to first-line chemotherapy.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Caspases; Cel | 2010 |
Combined inhibition of DNA methyltransferase and histone deacetylase restores caspase-8 expression and sensitizes SCLC cells to TRAIL.
Topics: Azacitidine; Blotting, Western; Caspase 8; Decitabine; DNA (Cytosine-5-)-Methyltransferase 1; DNA (C | 2011 |