valproic acid has been researched along with Sleep Wake Disorders in 27 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Sleep Wake Disorders: Abnormal sleep-wake schedule or pattern associated with the CIRCADIAN RHYTHM which affect the length, timing, and/or rigidity of the sleep-wake cycle relative to the day-night cycle.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The goal of this study was to determine if manifestations of agitation (ie, physical aggression, physically nonaggressive behavior, and verbally agitated behaviors) show different degrees of response to divalproex sodium (extended release or sprinkles) alone or in combination with second-generation antipsychotic agents." | 2.73 | Report on an open-label prospective study of divalproex sodium for the behavioral and psychological symptoms of dementia as monotherapy and in combination with second-generation antipsychotic medication. ( Adkison, L; Ahokpossi, C; Forester, B; Hyde, J; Perez, R; Sribney, W; Vanelli, M, 2007) |
| "The patient had initial seizures during sleep at the age of 1 year, with the left mouth pouting, left eye blinking and drooling for several seconds, and, sometimes, the left upper-limb flexion and head version to the left, lasting for 1-2 min." | 1.51 | Acquired epileptiform opercular syndrome evaluated with real-time transcranial Doppler ultrasound-video-electroencephalogram before and after treatment: a case report. ( Chen, WX; Li, JL; Liang, HC; Liang, W; Peng, BW; Yang, SY; Zhang, FQ, 2019) |
| "Three study groups: - 1) juvenile myoclonic epilepsy (N=40) [drug naïve (N=20); On sodium valproate (SVA) (N=20)]; 2) symptomatic partial epilepsy (N=40) [drug naïve (N=20); On carbamazepine (CBZ) (N=20)]; 3) healthy controls (N=40) completed 3 standardized sleep questionnaires - Epworth Sleepiness Scale, Pittsburgh Sleep Quality Index, and NIMHANS Comprehensive Sleep Disorders Questionnaire." | 1.46 | Comparing sleep profiles between patients with juvenile myoclonic epilepsy and symptomatic partial epilepsy: Sleep questionnaire-based study. ( Nagappa, M; Nayak, C; Saraswati, N; Sinha, S; Taly, AB; Thennarasu, K, 2017) |
| " Chronic administration of lithium chloride or valproic acid, two clinically effective mood stabilizers, reverses the majority of these behavioral abnormalities." | 1.42 | Mice heterozygous for cathepsin D deficiency exhibit mania-related behavior and stress-induced depression. ( Duan, S; Han, Y; Li, X; Lou, H; Lu, Y; Zhen, X; Zhou, R; Zhu, L, 2015) |
| "Clonazepam was stopped." | 1.36 | Late-onset nocturnal intractable seizure during sleep: what is the origin? ( Liesiene, V; Miliauskas, S; Sakalauskas, R; Zemaitis, M, 2010) |
| "The treatment with valproic acid (VPA) and clonazepam (CZP), has been very effective." | 1.30 | [Atypical benign partial epilepsy of childhood. Clinical follow-up EEG study of 3 patients]. ( Bauzano-Poley, E; Delgado-Marqués, MP; Mora-Ramírez, MD; Rodríguez-Barrionuevo, AC; Tosina-García, E, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (18.52) | 18.7374 |
| 1990's | 2 (7.41) | 18.2507 |
| 2000's | 7 (25.93) | 29.6817 |
| 2010's | 13 (48.15) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mekky, JF | 1 |
| Elbhrawy, SM | 1 |
| Boraey, MF | 1 |
| Omar, HM | 1 |
| Xu, L | 1 |
| Guo, D | 1 |
| Liu, YY | 1 |
| Qiao, DD | 1 |
| Ye, JY | 1 |
| Xue, R | 1 |
| Peng, BW | 1 |
| Liang, HC | 1 |
| Li, JL | 1 |
| Yang, SY | 1 |
| Liang, W | 1 |
| Zhang, FQ | 1 |
| Chen, WX | 1 |
| Krishnan, P | 2 |
| Sinha, S | 3 |
| Taly, AB | 3 |
| Ramachandraiah, CT | 2 |
| Rao, S | 2 |
| Satishchandra, P | 2 |
| Cusmano, DM | 1 |
| Mong, JA | 1 |
| Galer, S | 1 |
| Urbain, C | 1 |
| De Tiège, X | 1 |
| Emeriau, M | 1 |
| Leproult, R | 1 |
| Deliens, G | 1 |
| Nonclerq, A | 1 |
| Peigneux, P | 1 |
| Van Bogaert, P | 1 |
| Zhou, R | 1 |
| Lu, Y | 1 |
| Han, Y | 1 |
| Li, X | 1 |
| Lou, H | 1 |
| Zhu, L | 1 |
| Zhen, X | 1 |
| Duan, S | 1 |
| Saraswati, N | 1 |
| Nayak, C | 1 |
| Nagappa, M | 1 |
| Thennarasu, K | 1 |
| Miliauskas, S | 1 |
| Liesiene, V | 1 |
| Zemaitis, M | 1 |
| Sakalauskas, R | 1 |
| Liukkonen, E | 1 |
| Kantola-Sorsa, E | 1 |
| Paetau, R | 1 |
| Gaily, E | 1 |
| Peltola, M | 1 |
| Granström, ML | 1 |
| Ermolenko, NA | 1 |
| Ermakov, AIu | 1 |
| Buchneva, IA | 1 |
| Zakharova, EI | 1 |
| Kalikina, TA | 1 |
| Boudebesse, C | 1 |
| Henry, C | 1 |
| Veggiotti, P | 1 |
| Termine, C | 1 |
| Granocchio, E | 1 |
| Bova, S | 1 |
| Papalia, G | 1 |
| Lanzi, G | 1 |
| Berigan, TR | 1 |
| Capovilla, G | 1 |
| Beccaria, F | 1 |
| Cagdas, S | 1 |
| Montagnini, A | 1 |
| Segala, R | 1 |
| Paganelli, D | 1 |
| Gupta, M | 1 |
| Aneja, S | 1 |
| Kohli, K | 1 |
| Forester, B | 1 |
| Vanelli, M | 1 |
| Hyde, J | 1 |
| Perez, R | 1 |
| Ahokpossi, C | 1 |
| Sribney, W | 1 |
| Adkison, L | 1 |
| Boeckh, E | 1 |
| Herranz, JL | 1 |
| Arteaga, R | 1 |
| Armijo, JA | 1 |
| Rodríguez-Barrionuevo, AC | 1 |
| Bauzano-Poley, E | 1 |
| Delgado-Marqués, MP | 1 |
| Mora-Ramírez, MD | 1 |
| Tosina-García, E | 1 |
| Ehrenberg, BL | 2 |
| Eisensehr, I | 1 |
| Corbett, KE | 1 |
| Crowley, PF | 1 |
| Walters, AS | 1 |
| Deckers, CL | 1 |
| Hekster, YA | 1 |
| Keyser, A | 1 |
| van Lier, HJ | 1 |
| Meinardi, H | 1 |
| Renier, WO | 1 |
| Shakir, RA | 1 |
| Nanda, RN | 1 |
| Lambie, DG | 1 |
| Johnson, RH | 1 |
| Maccario, M | 1 |
| Lustman, LI | 1 |
| Pies, R | 1 |
| Adler, DA | 1 |
| Borsook, D | 1 |
| Richardson, GS | 1 |
| Moore-Ede, MC | 1 |
| Brennan, MJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Investigating the Effect of Closed-loop Auditory Stimulation on Sleep and Behavior in Patients With Epilepsy and Healthy Controls: a Developmental Study[NCT04716673] | 120 participants (Anticipated) | Interventional | 2020-07-29 | Recruiting | |||
| Effect of Melatonin on Seizure Outcome, Neuronal Damage and Quality of Life in Patients With Generalized Epilepsy: A Randomized, add-on Placebo-controlled Clinical Trial[NCT03590197] | Phase 4 | 104 participants (Actual) | Interventional | 2018-08-06 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for valproic acid and Sleep Wake Disorders
| Article | Year |
|---|---|
Juvenile myoclonic epilepsy and sleep.
Topics: Adolescent; Adult; Circadian Rhythm; Electroencephalography; Epilepsy, Reflex; Female; Humans; Male; | 2018 |
[Emotional hyper-reactivity and sleep disturbances in remitted patients with bipolar disorders].
Topics: Affect; Amygdala; Anticonvulsants; Antimanic Agents; Arousal; Bipolar Disorder; Combined Modality Th | 2012 |
6 trials available for valproic acid and Sleep Wake Disorders
| Article | Year |
|---|---|
Long-term neuropsychological follow-up and nosological considerations in five patients with continuous spikes and waves during slow sleep.
Topics: Adrenocorticotropic Hormone; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Child; Child, Pr | 2002 |
Efficacy of levetiracetam in pharmacoresistant continuous spikes and waves during slow sleep.
Topics: Action Potentials; Anticonvulsants; Cerebral Cortex; Child; Child, Preschool; Drug Resistance; Drug | 2004 |
Add-on melatonin improves sleep behavior in children with epilepsy: randomized, double-blind, placebo-controlled trial.
Topics: Anticonvulsants; Child; Child, Preschool; Double-Blind Method; Drug Therapy, Combination; Epilepsies | 2005 |
Report on an open-label prospective study of divalproex sodium for the behavioral and psychological symptoms of dementia as monotherapy and in combination with second-generation antipsychotic medication.
Topics: Aged; Aged, 80 and over; Aggression; Antimanic Agents; Antipsychotic Agents; Behavioral Symptoms; De | 2007 |
Valproate for sleep consolidation in periodic limb movement disorder.
Topics: Adult; Anticonvulsants; Arousal; Electroencephalography; Female; Humans; Leg; Male; Middle Aged; Noc | 2000 |
Monotherapy versus polytherapy for epilepsy: a multicenter double-blind randomized study.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Cognition Disorders; Double-Blind Method; Drug Ad | 2001 |
19 other studies available for valproic acid and Sleep Wake Disorders
| Article | Year |
|---|---|
Sleep architecture in patients with Juvenile Myoclonic Epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Electroencephalography; Female; Humans; Male; Myoclonic Epilepsy | 2017 |
Acquired epileptiform opercular syndrome evaluated with real-time transcranial Doppler ultrasound-video-electroencephalogram before and after treatment: a case report.
Topics: Anticonvulsants; Child, Preschool; Electroencephalography; Humans; Male; Methylprednisolone; Seizure | 2019 |
Altered polysomnographic profile in juvenile myoclonic epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Brain Waves; Case-Control Studies; Cross-Sectional Studies; Elec | 2014 |
In utero exposure to valproic acid changes sleep in juvenile rats: a model for sleep disturbances in autism.
Topics: Aging; Animals; Arousal; Child Development Disorders, Pervasive; Circadian Rhythm; Disease Models, A | 2014 |
Impaired sleep-related consolidation of declarative memories in idiopathic focal epilepsies of childhood.
Topics: Anticonvulsants; Child; Electroencephalography; Epilepsies, Partial; Epilepsy, Rolandic; Female; Hum | 2015 |
Mice heterozygous for cathepsin D deficiency exhibit mania-related behavior and stress-induced depression.
Topics: Adaptation, Ocular; Animals; Antidepressive Agents; Bipolar Disorder; Cathepsin D; Corticosterone; D | 2015 |
Comparing sleep profiles between patients with juvenile myoclonic epilepsy and symptomatic partial epilepsy: Sleep questionnaire-based study.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Epilepsies, Partial; Female; Humans; Male; Myoclo | 2017 |
Late-onset nocturnal intractable seizure during sleep: what is the origin?
Topics: Anticonvulsants; Clonazepam; Epilepsy; Follow-Up Studies; Humans; Male; Middle Aged; Polysomnography | 2010 |
Long-term outcome of 32 children with encephalopathy with status epilepticus during sleep, or ESES syndrome.
Topics: Adolescent; Anticonvulsants; Child; Cognition Disorders; Drug Therapy, Combination; Electroencephalo | 2010 |
Sleep disturbances in juvenile myoclonic epilepsy: a sleep questionnaire-based study.
Topics: Adolescent; Adult; Anticonvulsants; Cross-Sectional Studies; Electroencephalography; Female; Humans; | 2012 |
[Epilepsies with electric status epilepticus in sleep: peculiarities of clinical course and rational approaches to treatment].
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Drug Resistance; Electricity; E | 2011 |
Possible role of divalproex sodium in sedation induced by antipsychotic medications.
Topics: Antimanic Agents; Antipsychotic Agents; Drug Interactions; Humans; Schizophrenia; Sleep Wake Disorde | 2004 |
[The alcohol withdrawal syndrome and its therapy].
Topics: Adult; Alcohol Withdrawal Delirium; Alcoholism; Humans; Middle Aged; Patient Compliance; Psychomotor | 1980 |
Side effects of sodium valproate in monotherapy controlled by plasma levels: a study in 88 pediatric patients.
Topics: Child; Child Behavior Disorders; Child, Preschool; Digestive System Diseases; Epilepsy; Female; Hair | 1982 |
[Atypical benign partial epilepsy of childhood. Clinical follow-up EEG study of 3 patients].
Topics: Anticonvulsants; Carbamazepine; Child, Preschool; Clonazepam; Electroencephalography; Epilepsies, Pa | 1998 |
Comparative trial of valproate sodium and clonazepam in chronic epilepsy.
Topics: Adult; Ataxia; Benzodiazepinones; Chronic Disease; Clonazepam; Drug Therapy, Combination; Epilepsy; | 1979 |
Paroxysmal nocturnal dystonia presenting as excessive daytime somnolence.
Topics: Adult; Carbamazepine; Diagnosis, Differential; Dystonia; Electroencephalography; Evaluation Studies | 1990 |
Sleep disorders and depression with atypical features: response to valproate.
Topics: Adult; Depressive Disorder; Electroencephalography; Epilepsies, Partial; Female; Humans; Male; Neuro | 1989 |
GABA and circadian timekeeping: implications for manic-depression and sleep disorders.
Topics: 4-Aminobutyrate Transaminase; Acetylcholine; Aldehyde Oxidoreductases; Animals; Benzodiazepines; Bip | 1986 |