valproic acid has been researched along with Sleep Apnea Syndromes in 5 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Sleep Apnea Syndromes: Disorders characterized by multiple cessations of respirations during sleep that induce partial arousals and interfere with the maintenance of sleep. Sleep apnea syndromes are divided into central (see SLEEP APNEA, CENTRAL), obstructive (see SLEEP APNEA, OBSTRUCTIVE), and mixed central-obstructive types.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Replacement of phenytoin by valproic acid resulted in a 100-lb weight gain, exacerbation of sleep apnea, and right heart failure." | 3.73 | Lethal obesity associated with sodium valproate in a brain-injured patient. ( Althoff, RR; Black, DN; Daye, K; Pelletier, CA, 2005) |
| " An association between weight gain, obstructive sleep apnea, and lithium treatment is also illustrated." | 3.68 | Four cases of obstructive sleep apnea associated with treatment-resistant mania. ( Alpert, JE; Frankenburg, FR; Hudson, JI; Keck, PE; Strakowski, SM; Teschke, GC; Tohen, M; Wilson, DR, 1991) |
| "Clonazepam was stopped." | 1.36 | Late-onset nocturnal intractable seizure during sleep: what is the origin? ( Liesiene, V; Miliauskas, S; Sakalauskas, R; Zemaitis, M, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Revol, B | 1 |
| Jullian-Desayes, I | 1 |
| Guichard, K | 1 |
| Micoulaud-Franchi, JA | 1 |
| Tamisier, R | 1 |
| Philip, P | 1 |
| Joyeux-Faure, M | 1 |
| Pépin, JL | 1 |
| Miliauskas, S | 1 |
| Liesiene, V | 1 |
| Zemaitis, M | 1 |
| Sakalauskas, R | 1 |
| Black, DN | 1 |
| Althoff, RR | 1 |
| Daye, K | 1 |
| Pelletier, CA | 1 |
| Semba, H | 1 |
| Sugawara, H | 1 |
| Otsuka, M | 1 |
| Ueki, A | 1 |
| Strakowski, SM | 1 |
| Hudson, JI | 1 |
| Keck, PE | 1 |
| Wilson, DR | 1 |
| Frankenburg, FR | 1 |
| Alpert, JE | 1 |
| Teschke, GC | 1 |
| Tohen, M | 1 |
5 other studies available for valproic acid and Sleep Apnea Syndromes
| Article | Year |
|---|---|
Valproic acid and sleep apnoea: A disproportionality signal from the WHO pharmacovigilance database.
Topics: Databases, Factual; Humans; Pharmacovigilance; Sleep Apnea Syndromes; Valproic Acid | 2020 |
Late-onset nocturnal intractable seizure during sleep: what is the origin?
Topics: Anticonvulsants; Clonazepam; Epilepsy; Follow-Up Studies; Humans; Male; Middle Aged; Polysomnography | 2010 |
Lethal obesity associated with sodium valproate in a brain-injured patient.
Topics: Adult; Anticonvulsants; Brain Injuries; Epilepsy; Fatal Outcome; Heart Failure; Humans; Male; Obesit | 2005 |
[Nocturnal epilepsy associated with sleep apnea syndrome].
Topics: Circadian Rhythm; Epilepsy; Humans; Intermittent Positive-Pressure Ventilation; Male; Middle Aged; P | 2007 |
Four cases of obstructive sleep apnea associated with treatment-resistant mania.
Topics: Adult; Bipolar Disorder; Clonazepam; Female; Follow-Up Studies; Hospitalization; Humans; Lithium; Mi | 1991 |