valproic acid has been researched along with Sjogren's Syndrome in 3 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Sjogren's Syndrome: Chronic inflammatory and autoimmune disease in which the salivary and lacrimal glands undergo progressive destruction by lymphocytes and plasma cells resulting in decreased production of saliva and tears. The primary form, often called sicca syndrome, involves both KERATOCONJUNCTIVITIS SICCA and XEROSTOMIA. The secondary form includes, in addition, the presence of a connective tissue disease, usually rheumatoid arthritis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The authors describe a case of a drug-associated hyperammonemia, central pontine myelinolysis and coma occurring in a patient with Sjögren's syndrome chronically treated with valproic acid for an underlying psychotic disorder." | 3.74 | [Hyperammoniemia and central pontine myelinolysis in a patient with Sjögren syndrome and chronic valproate use]. ( Battaglia, K; Berlot, G; Ukmar, M, 2008) |
| "Primary Sjogren syndrome is considered as the most frequent connective tissue disease." | 1.33 | [Sjögren's syndrome with autonomic failure and epilepsy]. ( Attout, H; Guez, S; Martre, A; Series, C, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Berlot, G | 1 |
| Battaglia, K | 1 |
| Ukmar, M | 1 |
| Nakazato, Y | 1 |
| Ando, S | 1 |
| Yamamoto, T | 1 |
| Tamura, N | 1 |
| Shimazu, K | 1 |
| Attout, H | 1 |
| Martre, A | 1 |
| Guez, S | 1 |
| Series, C | 1 |
3 other studies available for valproic acid and Sjogren's Syndrome
| Article | Year |
|---|---|
[Hyperammoniemia and central pontine myelinolysis in a patient with Sjögren syndrome and chronic valproate use].
Topics: Adult; Antimanic Agents; Female; Humans; Hyperammonemia; Myelinolysis, Central Pontine; Sjogren's Sy | 2008 |
[Valproate-induced hyperammonemic encephalopathy in a patient with Sjögren's syndrome].
Topics: Anticonvulsants; Epilepsy; Female; Humans; Hyperammonemia; Magnetic Resonance Imaging; Middle Aged; | 2004 |
[Sjögren's syndrome with autonomic failure and epilepsy].
Topics: Aged; Anti-Inflammatory Agents; Anticonvulsants; Autonomic Nervous System Diseases; Electromyography | 2005 |