valproic acid has been researched along with Serotonin Syndrome in 5 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Serotonin Syndrome: An adverse drug interaction characterized by altered mental status, autonomic dysfunction, and neuromuscular abnormalities. It is most frequently caused by use of both serotonin reuptake inhibitors and monoamine oxidase inhibitors, leading to excess serotonin availability in the CNS at the serotonin 1A receptor.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Serotonin syndrome and neuroleptic malignant syndrome are two drug toxidromes that have often overlapping and confusing clinical pictures." | 2.50 | Serotonin syndrome versus neuroleptic malignant syndrome: a challenging clinical quandary. ( Ambaliya, A; Dosi, R; Joshi, H; Patell, R, 2014) |
| "Lamotrigine is a novel anticonvulsant drug which also stabilises mood in bipolar illness via an unknown mechanism." | 1.30 | Lamotrigine inhibits monoamine uptake in vitro and modulates 5-hydroxytryptamine uptake in rats. ( Hagan, RM; Higgins, GA; Kirkby, D; Southam, E, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhan, Z | 1 |
| Cao, CS | 1 |
| Huang, L | 1 |
| Prakash, S | 1 |
| Adroja, B | 1 |
| Parekh, H | 1 |
| Dosi, R | 1 |
| Ambaliya, A | 1 |
| Joshi, H | 1 |
| Patell, R | 1 |
| Rachid, F | 1 |
| Golaz, J | 1 |
| Bondolfi, G | 1 |
| Bertschy, G | 1 |
| Southam, E | 1 |
| Kirkby, D | 1 |
| Higgins, GA | 1 |
| Hagan, RM | 1 |
1 review available for valproic acid and Serotonin Syndrome
| Article | Year |
|---|---|
Serotonin syndrome versus neuroleptic malignant syndrome: a challenging clinical quandary.
Topics: Antimanic Agents; Antipsychotic Agents; Benzodiazepines; Clonazepam; Diagnosis, Differential; GABA M | 2014 |
4 other studies available for valproic acid and Serotonin Syndrome
| Article | Year |
|---|---|
Serotonin Syndrome Induced by a Single Dose of Venlafaxine and Magnesium Valproate.
Topics: Cyclohexanols; Humans; Selective Serotonin Reuptake Inhibitors; Serotonin; Serotonin Syndrome; Valpr | 2021 |
Serotonin syndrome in patients with headache disorders.
Topics: Acetaminophen; Adult; Amitriptyline; Analgesics; Cluster Headache; Drug Therapy, Combination; Flunar | 2017 |
Induction of a mixed depressive episode during rTMS treatment in a patient with refractory major depression.
Topics: Adult; Amitriptyline; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Antidepressive | 2006 |
Lamotrigine inhibits monoamine uptake in vitro and modulates 5-hydroxytryptamine uptake in rats.
Topics: Acetates; Amines; Animals; Anticonvulsants; Biogenic Amines; Blood Platelets; Brain; Carbamazepine; | 1998 |