valproic acid has been researched along with Sepsis in 8 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Sepsis: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sepsis is a leading cause of death and disability worldwide." | 5.51 | Valproic acid attenuates sepsis-induced myocardial dysfunction in rats by accelerating autophagy through the PTEN/AKT/mTOR pathway. ( Liu, Y; Shi, X; Xiao, D; Zhang, D, 2019) |
| "Valproic acid (VPA) has been shown to exert anti-inflammatory and antioxidant effects in a range of diseases including septic shock." | 5.39 | Valproic acid attenuates lipopolysaccharide-induced acute lung injury in mice. ( Fan, YX; Gao, DP; Ji, MH; Jia, M; Li, GM; Wu, J; Yang, JJ; Zhu, SH, 2013) |
| " We investigated for the first time whether class I histone deacetylase inhibitor valproic acid (VPA) can reverse cognitive deficits in a mouse model of sepsis-associated encephalopathy (SAE)." | 3.79 | Class I histone deacetylase inhibitor valproic acid reverses cognitive deficits in a mouse model of septic encephalopathy. ( Dong, L; Ji, M; Jia, M; Qiu, L; Wu, J; Yang, J; Zhang, G; Zhang, M, 2013) |
| "Sepsis is a leading cause of death and disability worldwide." | 1.51 | Valproic acid attenuates sepsis-induced myocardial dysfunction in rats by accelerating autophagy through the PTEN/AKT/mTOR pathway. ( Liu, Y; Shi, X; Xiao, D; Zhang, D, 2019) |
| "Valproic acid (VPA) has been shown to exert anti-inflammatory and antioxidant effects in a range of diseases including septic shock." | 1.39 | Valproic acid attenuates lipopolysaccharide-induced acute lung injury in mice. ( Fan, YX; Gao, DP; Ji, MH; Jia, M; Li, GM; Wu, J; Yang, JJ; Zhu, SH, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 6 (75.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| De Fazio, C | 1 |
| Goffin, M | 1 |
| Franchi, F | 1 |
| Ferlini, L | 1 |
| Orinckx, C | 1 |
| Spadaro, S | 1 |
| Brasseur, A | 1 |
| Gaspard, N | 1 |
| Antonucci, E | 1 |
| Khattar, L | 1 |
| Peluso, L | 1 |
| Romeo, I | 1 |
| Creteur, J | 1 |
| Legros, B | 1 |
| Taccone, FS | 1 |
| Shi, X | 1 |
| Liu, Y | 1 |
| Zhang, D | 1 |
| Xiao, D | 1 |
| Amathieu, R | 1 |
| Levesque, E | 1 |
| Merle, JC | 1 |
| Chemit, M | 1 |
| Costentin, C | 1 |
| Compagnon, P | 1 |
| Dhonneur, G | 1 |
| Ji, MH | 1 |
| Li, GM | 1 |
| Jia, M | 2 |
| Zhu, SH | 1 |
| Gao, DP | 1 |
| Fan, YX | 1 |
| Wu, J | 2 |
| Yang, JJ | 1 |
| Dong, L | 1 |
| Zhang, M | 1 |
| Zhang, G | 1 |
| Qiu, L | 1 |
| Ji, M | 1 |
| Yang, J | 1 |
| Zheng, Q | 1 |
| Liu, W | 1 |
| Liu, Z | 1 |
| Zhao, H | 1 |
| Han, X | 1 |
| Zhao, M | 1 |
| Qureshi, AU | 1 |
| Abbas, R | 1 |
| Ahmad, TM | 1 |
| Clause, D | 1 |
| Decleire, PY | 1 |
| Vanbinst, R | 1 |
| Soyer, A | 1 |
| Hantson, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of Valproic Acid (VPA) as Adjunctive Therapy for Liver Transplant Patients With Moderate to Severe Hemorrhage at Risk of Ischemia Reperfusion (I/R) Injury[NCT04531592] | Phase 2 | 0 participants (Actual) | Interventional | 2022-01-31 | Withdrawn (stopped due to Study terminated by the Sponsor) | ||
| Evaluation of Valproic Acid (VPA) as Adjunctive Therapy for Trauma Patients With Moderate to Severe Hemorrhage at Risk of Ischemia Reperfusion (I/R) Injury[NCT04531579] | Phase 2 | 0 participants (Actual) | Interventional | 2022-01-31 | Withdrawn (stopped due to Study terminated by the Sponsor.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for valproic acid and Sepsis
| Article | Year |
|---|---|
[Severe toxic acute liver failure: etiology and treatment].
Topics: Acetaminophen; Acetylcysteine; Acute Kidney Injury; Anti-Infective Agents; Blood Coagulation Disorde | 2013 |
7 other studies available for valproic acid and Sepsis
| Article | Year |
|---|---|
Hyperammonemia during treatment with valproate in critically ill patients.
Topics: Aged; Critical Care; Critical Illness; Enzyme Inhibitors; Female; Humans; Hyperammonemia; Incidence; | 2022 |
Valproic acid attenuates sepsis-induced myocardial dysfunction in rats by accelerating autophagy through the PTEN/AKT/mTOR pathway.
Topics: Animals; Autophagy; Cecum; Disease Models, Animal; Histone Deacetylase Inhibitors; Histone Deacetyla | 2019 |
Valproic acid attenuates lipopolysaccharide-induced acute lung injury in mice.
Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Antioxidants; Bronchoalveolar Lavage Fluid; Do | 2013 |
Class I histone deacetylase inhibitor valproic acid reverses cognitive deficits in a mouse model of septic encephalopathy.
Topics: Animals; Brain Diseases; Brain-Derived Neurotrophic Factor; Carbazoles; Cecum; Cognition Disorders; | 2013 |
Valproic acid protects septic mice from renal injury by reducing the inflammatory response.
Topics: Acute Kidney Injury; Animals; Cecum; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Histone | 2014 |
Valproic acid protects septic mice from renal injury by reducing the inflammatory response.
Topics: Acute Kidney Injury; Animals; Cecum; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Histone | 2014 |
Valproic acid protects septic mice from renal injury by reducing the inflammatory response.
Topics: Acute Kidney Injury; Animals; Cecum; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Histone | 2014 |
Valproic acid protects septic mice from renal injury by reducing the inflammatory response.
Topics: Acute Kidney Injury; Animals; Cecum; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Histone | 2014 |
A case of polyglandular autoimmune syndrome type I with unusual presentation.
Topics: Alcaligenes faecalis; Anti-Bacterial Agents; Anti-Inflammatory Agents; Anticonvulsants; Antifungal A | 2011 |
Pharmacokinetic interaction between valproic acid and meropenem.
Topics: Adult; Aged; Anticonvulsants; Drug Interactions; Humans; Male; Meropenem; Seizures; Sepsis; Thienamy | 2005 |