valproic acid has been researched along with Sensitivity and Specificity in 56 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Because the pharmacokinetic evaluation of valproic acid (VPA) based on total drug concentration may be misleading in patients with hypoalbuminemia as a result of saturable protein binding and saturable metabolism, we sought to investigate the usefulness of therapeutic drug monitoring of unbound VPA concentration in a real-world clinical context, with a focus on clinically significant neurologic adverse outcomes." | 7.85 | Clinical Importance of Monitoring Unbound Valproic Acid Concentration in Patients with Hypoalbuminemia. ( Doré, M; Frenette, AJ; San Juan, AE; Williamson, D, 2017) |
| "To determine the sensitivity and specificity of detecting urinary medium-chain acylcarnitines for the diagnosis of MCAD deficiency, 114 urine specimens from 75 children with metabolic diseases and controls were analyzed in a blinded fashion using a radioisotopic exchange/HPLC method." | 7.68 | Urinary medium-chain acylcarnitines in medium-chain acyl-CoA dehydrogenase deficiency, medium-chain triglyceride feeding and valproic acid therapy: sensitivity and specificity of the radioisotopic exchange/high performance liquid chromatography method. ( Gage, DA; Huang, ZH; Kossak, D; Li, BU; Penn, D; Rinaldo, P; Schmidt-Sommerfeld, E, 1992) |
| "Because the pharmacokinetic evaluation of valproic acid (VPA) based on total drug concentration may be misleading in patients with hypoalbuminemia as a result of saturable protein binding and saturable metabolism, we sought to investigate the usefulness of therapeutic drug monitoring of unbound VPA concentration in a real-world clinical context, with a focus on clinically significant neurologic adverse outcomes." | 3.85 | Clinical Importance of Monitoring Unbound Valproic Acid Concentration in Patients with Hypoalbuminemia. ( Doré, M; Frenette, AJ; San Juan, AE; Williamson, D, 2017) |
| "To evaluate clinical efficacy of clozapine in relation with its plasma level in a group of Chinese patients with treatment-resistant schizophrenia." | 3.73 | Plasma clozapine levels and clinical response in treatment-refractory Chinese schizophrenic patients. ( Chan, KT; Choi, WK; Hon-Kee Cheung, H; Lai, J; Leung, SP; Mak, T; Ng, RM; Wai-Kiu Tsang, A; Wong, JO, 2006) |
| "Sixty critically ill pediatric patients receiving phenytoin for treatment of seizures in a large multidisciplinary intensive care unit." | 3.73 | Total phenytoin concentrations do not accurately predict free phenytoin concentrations in critically ill children. ( Dodson, B; McClain, CD; McManus, ML; Wolf, GK; Zurakowski, D, 2006) |
| "To determine the sensitivity and specificity of detecting urinary medium-chain acylcarnitines for the diagnosis of MCAD deficiency, 114 urine specimens from 75 children with metabolic diseases and controls were analyzed in a blinded fashion using a radioisotopic exchange/HPLC method." | 3.68 | Urinary medium-chain acylcarnitines in medium-chain acyl-CoA dehydrogenase deficiency, medium-chain triglyceride feeding and valproic acid therapy: sensitivity and specificity of the radioisotopic exchange/high performance liquid chromatography method. ( Gage, DA; Huang, ZH; Kossak, D; Li, BU; Penn, D; Rinaldo, P; Schmidt-Sommerfeld, E, 1992) |
| "Despite promising new therapies, bipolar depression remains difficult to treat." | 2.72 | Inositol augmentation of lithium or valproate for bipolar depression. ( Culhane, M; Demopulos, C; Eden Evins, A; Grandin, LD; Nierenberg, AA; Ogutha, J; Sachs, GS; Yovel, I, 2006) |
| "From these analyses, breast tumors are predicted to be sensitive to VPA." | 2.47 | A pharmacogenomic method for individualized prediction of drug sensitivity. ( Bild, AH; Chang, JT; Cohen, AL; Gustafson, AM; Jeffrey, SS; Johnson, E; Soldi, R; Spira, A; Welm, BE; Wilcox, R; Zhang, H, 2011) |
| "Valproic acid (VA) is a drug widely used on the treatment of epilepsy and bipolar affective disorders, with stablished therapeutic concentration ranges in serum." | 1.62 | Simple determination of valproic acid serum concentrations using BioSPME followed by gas chromatography-mass spectrometric analysis. ( Antunes, MV; de Lima Feltraco Lizot, L; Hahn, RZ; Linden, R; Schaefer, VD; Schneider, A, 2021) |
| "Valproic acid (VPA) dosing needs to be individualized for epilepsy patients through therapeutic drug monitoring (TDM)." | 1.62 | Therapeutic drug monitoring of valproic acid using a dried plasma spot sampling device. ( Cao, H; Huang, J; Jiang, Y; Li, Y; Lin, H; Ren, W; Zhang, J, 2021) |
| "Coexisting psychiatric disorders (PDs) were found in 33." | 1.40 | Factors associated with lack of response to valproic acid monotherapy in juvenile myoclonic epilepsy. ( Bana, AK; Jayalakshmi, S; Mohandas, S; Sailaja, S; Somayajula, S; Vooturi, S, 2014) |
| "Phenytoin assays were evaluated using an additional set of samples from patients with abnormal renal function." | 1.31 | Performance characteristics of four immunoassays for antiepileptic drugs on the IMMULITE 2000 automated analyzer. ( Annesley, TM; Frank, EL; Juenke, J; Roberts, WL; Schwarz, EL, 2002) |
| "Valproic acid was converted directly into its pentafluorobenzyl ester derivative without the need to perform any extraction from the biologic fluid." | 1.31 | Assessment of drug concentrations in tears in therapeutic drug monitoring: I. Determination of valproic acid in tears by gas chromatography/mass spectrometry with EC/NCI mode. ( Honda, A; Kitagawa, S; Miyamoto, J; Miyazaki, H; Nakajima, M; Ohya, M; Sato, S; Shimada, K; Shoda, J; Yamato, S, 2000) |
| "Mefenamic acid (MA) is a nonsteroidal antiinflammatory analgesic agent widely used clinically." | 1.28 | Rapid and sensitive liquid chromatographic assay of mefenamic acid in plasma. ( Cheymol, G; Lebot, M; Poirier, JM, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (12.50) | 18.2507 |
| 2000's | 26 (46.43) | 29.6817 |
| 2010's | 21 (37.50) | 24.3611 |
| 2020's | 2 (3.57) | 2.80 |
| Authors | Studies |
|---|---|
| Iwamura, A | 1 |
| Fukami, T | 1 |
| Hosomi, H | 1 |
| Nakajima, M | 2 |
| Yokoi, T | 1 |
| Papastavrou, N | 1 |
| Chatzopoulou, M | 1 |
| Ballekova, J | 1 |
| Cappiello, M | 1 |
| Moschini, R | 1 |
| Balestri, F | 1 |
| Patsilinakos, A | 1 |
| Ragno, R | 1 |
| Stefek, M | 1 |
| Nicolaou, I | 1 |
| Schaefer, VD | 1 |
| de Lima Feltraco Lizot, L | 1 |
| Hahn, RZ | 1 |
| Schneider, A | 1 |
| Antunes, MV | 1 |
| Linden, R | 1 |
| Li, Y | 2 |
| Jiang, Y | 1 |
| Cao, H | 1 |
| Lin, H | 1 |
| Ren, W | 1 |
| Huang, J | 1 |
| Zhang, J | 1 |
| Doré, M | 1 |
| San Juan, AE | 1 |
| Frenette, AJ | 1 |
| Williamson, D | 1 |
| Kim, D | 1 |
| Garza, LA | 1 |
| Linder, C | 1 |
| Hansson, A | 1 |
| Sadek, S | 1 |
| Gustafsson, LL | 1 |
| Pohanka, A | 1 |
| Wen, D | 1 |
| Chen, Z | 2 |
| Yang, C | 1 |
| Liu, H | 1 |
| Li, H | 2 |
| Chen, J | 1 |
| Dai, Q | 1 |
| Zhong, G | 1 |
| Qin, J | 1 |
| Ni, G | 1 |
| Huang, M | 1 |
| Zhou, L | 1 |
| Wang, X | 2 |
| Aquadro, E | 1 |
| Youssef, NA | 1 |
| Wu, D | 1 |
| Li, Q | 1 |
| Zhu, X | 1 |
| Wu, G | 1 |
| Cui, S | 1 |
| Jayalakshmi, S | 1 |
| Vooturi, S | 1 |
| Bana, AK | 1 |
| Sailaja, S | 1 |
| Somayajula, S | 1 |
| Mohandas, S | 1 |
| Ikeda, K | 1 |
| Ikawa, K | 1 |
| Yokoshige, S | 1 |
| Yoshikawa, S | 1 |
| Morikawa, N | 1 |
| Deeb, S | 1 |
| McKeown, DA | 1 |
| Torrance, HJ | 1 |
| Wylie, FM | 1 |
| Logan, BK | 1 |
| Scott, KS | 1 |
| Aebischer, B | 1 |
| Elsig, S | 1 |
| Taeymans, J | 1 |
| Pomp, S | 1 |
| Kuhness, D | 1 |
| Barcaro, G | 1 |
| Sementa, L | 1 |
| Mankad, V | 1 |
| Fortunelli, A | 1 |
| Sterrer, M | 1 |
| Netzer, FP | 1 |
| Surnev, S | 1 |
| Schmieder, AH | 1 |
| Caruthers, SD | 1 |
| Keupp, J | 1 |
| Wickline, SA | 1 |
| Lanza, GM | 1 |
| Lowe, J | 1 |
| Wodarcyk, AJ | 1 |
| Floyd, KT | 1 |
| Rastogi, N | 1 |
| Schultz, EJ | 1 |
| Swager, SA | 1 |
| Chadwick, JA | 1 |
| Tran, T | 1 |
| Raman, SV | 1 |
| Janssen, PM | 1 |
| Rafael-Fortney, JA | 1 |
| Alcalay, RN | 1 |
| Levy, OA | 1 |
| Wolf, P | 1 |
| Oliva, P | 1 |
| Zhang, XK | 1 |
| Waters, CH | 1 |
| Fahn, S | 1 |
| Kang, U | 1 |
| Liong, C | 1 |
| Ford, B | 1 |
| Mazzoni, P | 1 |
| Kuo, S | 1 |
| Johnson, A | 1 |
| Xiong, L | 1 |
| Rouleau, GA | 1 |
| Chung, W | 1 |
| Marder, KS | 1 |
| Gan-Or, Z | 1 |
| Kamei, K | 1 |
| Terao, T | 1 |
| Katayama, Y | 1 |
| Hatano, K | 1 |
| Kodama, K | 1 |
| Shirahama, M | 1 |
| Sakai, A | 1 |
| Hirakawa, H | 1 |
| Mizokami, Y | 1 |
| Shiotsuki, I | 1 |
| Ishii, N | 1 |
| Inoue, Y | 1 |
| Akboga, MK | 1 |
| Yayla, C | 1 |
| Balci, KG | 1 |
| Ozeke, O | 1 |
| Maden, O | 1 |
| Kisacik, H | 1 |
| Temizhan, A | 1 |
| Aydogdu, S | 1 |
| Zhu, J | 2 |
| Ying, SH | 1 |
| Feng, MG | 1 |
| Zhang, XG | 1 |
| Wang, L | 1 |
| Hao, YY | 1 |
| Liang, GD | 1 |
| Ma, YH | 1 |
| Yang, GS | 1 |
| Hu, JH | 1 |
| Pfeifer, L | 1 |
| Goertz, RS | 1 |
| Neurath, MF | 1 |
| Strobel, D | 1 |
| Wildner, D | 1 |
| Lin, JT | 1 |
| Yang, XN | 1 |
| Zhong, WZ | 1 |
| Liao, RQ | 1 |
| Dong, S | 1 |
| Nie, Q | 1 |
| Weng, SX | 1 |
| Fang, XJ | 1 |
| Zheng, JY | 1 |
| Wu, YL | 1 |
| Řezanka, T | 1 |
| Kaineder, K | 1 |
| Mezricky, D | 1 |
| Řezanka, M | 1 |
| Bišová, K | 1 |
| Zachleder, V | 1 |
| Vítová, M | 1 |
| Rinker, JA | 1 |
| Marshall, SA | 1 |
| Mazzone, CM | 1 |
| Lowery-Gionta, EG | 1 |
| Gulati, V | 1 |
| Pleil, KE | 1 |
| Kash, TL | 1 |
| Navarro, M | 1 |
| Thiele, TE | 1 |
| Zhang, Y | 1 |
| Huang, Y | 1 |
| Jin, Z | 1 |
| Li, X | 1 |
| Li, B | 1 |
| Xu, P | 1 |
| Huang, P | 1 |
| Liu, C | 1 |
| Fokdal, L | 1 |
| Sturdza, A | 1 |
| Mazeron, R | 1 |
| Haie-Meder, C | 1 |
| Tan, LT | 1 |
| Gillham, C | 1 |
| Šegedin, B | 1 |
| Jürgenliemk-Schultz, I | 1 |
| Kirisits, C | 1 |
| Hoskin, P | 1 |
| Pötter, R | 1 |
| Lindegaard, JC | 1 |
| Tanderup, K | 1 |
| Levin, DE | 1 |
| Schmitz, AJ | 1 |
| Hines, SM | 1 |
| Hines, KJ | 1 |
| Tucker, MJ | 1 |
| Brewer, SH | 1 |
| Fenlon, EE | 1 |
| Álvarez-Pérez, S | 1 |
| Blanco, JL | 1 |
| Peláez, T | 1 |
| Martínez-Nevado, E | 1 |
| García, ME | 1 |
| Puckerin, AA | 1 |
| Chang, DD | 1 |
| Subramanyam, P | 1 |
| Colecraft, HM | 1 |
| Dogan, H | 1 |
| Coteli, E | 1 |
| Karatas, F | 1 |
| Ceylan, O | 1 |
| Sahin, MD | 1 |
| Akdamar, G | 1 |
| Kryczyk, A | 1 |
| Żmudzki, P | 1 |
| Hubicka, U | 1 |
| Giovannelli, D | 1 |
| Chung, M | 1 |
| Staley, J | 1 |
| Starovoytov, V | 1 |
| Le Bris, N | 1 |
| Vetriani, C | 1 |
| Chen, W | 3 |
| Wu, L | 1 |
| Liu, X | 1 |
| Shen, Y | 1 |
| Liang, Y | 1 |
| Tan, H | 1 |
| Yang, Y | 1 |
| Liu, Q | 1 |
| Wang, M | 1 |
| Liu, L | 1 |
| Liu, B | 2 |
| Liu, GH | 1 |
| Zhu, YJ | 1 |
| Wang, JP | 1 |
| Che, JM | 1 |
| Chen, QQ | 1 |
| Maucksch, U | 1 |
| Runge, R | 1 |
| Wunderlich, G | 1 |
| Freudenberg, R | 1 |
| Naumann, A | 1 |
| Kotzerke, J | 1 |
| Soni, K | 1 |
| Patel, N | 1 |
| Singh, K | 1 |
| Jha, A | 1 |
| Patel, H | 1 |
| Gupta, R | 1 |
| Srinivas, NR | 1 |
| Wang, Z | 1 |
| Yun, Y | 2 |
| Xie, X | 1 |
| You, C | 1 |
| Miao, H | 2 |
| Zhang, F | 1 |
| Gao, S | 2 |
| Chen, LC | 1 |
| Hashimoto, Y | 1 |
| Furuya, H | 1 |
| Takekawa, K | 1 |
| Kubota, T | 1 |
| Hiraoka, K | 1 |
| West, AE | 1 |
| Celio, CI | 1 |
| Henry, DB | 1 |
| Pavuluri, MN | 1 |
| Tao, X | 1 |
| Jiang, B | 1 |
| Xiao, Y | 1 |
| Cai, F | 1 |
| Li, J | 1 |
| Cohen, AL | 1 |
| Soldi, R | 1 |
| Zhang, H | 1 |
| Gustafson, AM | 1 |
| Wilcox, R | 1 |
| Welm, BE | 1 |
| Chang, JT | 1 |
| Johnson, E | 1 |
| Spira, A | 1 |
| Jeffrey, SS | 1 |
| Bild, AH | 1 |
| Kim, KB | 1 |
| Seo, KA | 1 |
| Kim, SE | 1 |
| Bae, SK | 1 |
| Kim, DH | 1 |
| Shin, JG | 1 |
| Causey, MW | 1 |
| Salgar, S | 1 |
| Singh, N | 1 |
| Martin, M | 1 |
| Stallings, JD | 1 |
| Mohammadi, B | 1 |
| Majnooni, MB | 1 |
| Khatabi, PM | 1 |
| Jalili, R | 1 |
| Bahrami, G | 1 |
| Ahmad, T | 1 |
| Shekh, K | 1 |
| Khan, S | 1 |
| Vikram, A | 1 |
| Yadav, L | 1 |
| Parekh, CV | 1 |
| Jena, GB | 1 |
| Frank, EL | 1 |
| Schwarz, EL | 1 |
| Juenke, J | 1 |
| Annesley, TM | 1 |
| Roberts, WL | 1 |
| Isoherranen, N | 1 |
| Yagen, B | 1 |
| Spiegelstein, O | 1 |
| Steinman, A | 1 |
| Finnell, RH | 1 |
| Bialer, M | 1 |
| Tutor-Crespo, MJ | 1 |
| Hermida, J | 1 |
| Tutor, JC | 1 |
| Dyszkiewicz-Korpanty, AM | 1 |
| Frenkel, EP | 1 |
| Sarode, R | 1 |
| Trus, MR | 1 |
| Yang, L | 1 |
| Suarez Saiz, F | 1 |
| Bordeleau, L | 1 |
| Jurisica, I | 1 |
| Minden, MD | 1 |
| Zhong, Y | 1 |
| Jiao, Z | 1 |
| Yu, Y | 1 |
| Pucci, V | 1 |
| Monteagudo, E | 1 |
| Bonelli, F | 1 |
| Pallanti, S | 1 |
| DeCaria, CM | 1 |
| Grant, JE | 1 |
| Urpe, M | 1 |
| Hollander, E | 1 |
| Wong, JO | 1 |
| Leung, SP | 1 |
| Mak, T | 1 |
| Ng, RM | 1 |
| Chan, KT | 1 |
| Hon-Kee Cheung, H | 1 |
| Choi, WK | 1 |
| Lai, J | 1 |
| Wai-Kiu Tsang, A | 1 |
| Wild, JM | 1 |
| Robson, CR | 1 |
| Jones, AL | 1 |
| Cunliffe, IA | 1 |
| Smith, PE | 1 |
| Eden Evins, A | 1 |
| Demopulos, C | 1 |
| Yovel, I | 1 |
| Culhane, M | 1 |
| Ogutha, J | 1 |
| Grandin, LD | 1 |
| Nierenberg, AA | 1 |
| Sachs, GS | 1 |
| Norouzi, P | 1 |
| Shirvani-Arani, S | 1 |
| Daneshgar, P | 1 |
| Ganjali, MR | 1 |
| Wolf, GK | 1 |
| McClain, CD | 1 |
| Zurakowski, D | 1 |
| Dodson, B | 1 |
| McManus, ML | 1 |
| Shahdousti, P | 1 |
| Mohammadi, A | 1 |
| Alizadeh, N | 1 |
| Hodges-Gallagher, L | 1 |
| Valentine, CD | 1 |
| Bader, SE | 1 |
| Kushner, PJ | 1 |
| Nikitina, TG | 1 |
| Adamson, VG | 1 |
| Dyskin, DE | 1 |
| Prokudin, MIu | 1 |
| Shaltiel, G | 1 |
| Dalton, EC | 1 |
| Belmaker, RH | 1 |
| Harwood, AJ | 1 |
| Agam, G | 1 |
| Yang, X | 1 |
| Janatova, J | 1 |
| Juenke, JM | 1 |
| McMillin, GA | 1 |
| Andrade, JD | 1 |
| Patel, NC | 1 |
| Patrick, DM | 1 |
| Youngstrom, EA | 1 |
| Strakowski, SM | 1 |
| Delbello, MP | 1 |
| Vermeij, TA | 1 |
| Edelbroek, PM | 1 |
| Jinjuvadia, K | 1 |
| Kwan, W | 1 |
| Fontana, RJ | 1 |
| Diermayr, S | 1 |
| Himmelreich, H | 1 |
| Durovic, B | 1 |
| Mathys-Schneeberger, A | 1 |
| Siegler, U | 1 |
| Langenkamp, U | 1 |
| Hofsteenge, J | 1 |
| Gratwohl, A | 1 |
| Tichelli, A | 1 |
| Paluszewska, M | 1 |
| Wiktor-Jedrzejczak, W | 1 |
| Kalberer, CP | 1 |
| Wodnar-Filipowicz, A | 1 |
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| Sailhamer, EA | 1 |
| Shults, C | 1 |
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| Poirier, JM | 1 |
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| Cheymol, G | 1 |
| Schmidt-Sommerfeld, E | 1 |
| Penn, D | 1 |
| Rinaldo, P | 1 |
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| Li, BU | 1 |
| Huang, ZH | 1 |
| Gage, DA | 1 |
| Jandreski, MA | 1 |
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| Garbincius, J | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Inositol for Comorbid Anxiety in Children and Adolescents With Bipolar Disorder[NCT02811133] | Phase 1/Phase 2 | 0 participants (Actual) | Interventional | 2023-08-31 | Withdrawn (stopped due to Funding terminated) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for valproic acid and Sensitivity and Specificity
| Article | Year |
|---|---|
Topics: AC133 Antigen; Acenaphthenes; Acer; Acrosome Reaction; Adult; Agaricales; Aged; Aged, 80 and over; A | 2016 |
Topics: AC133 Antigen; Acenaphthenes; Acer; Acrosome Reaction; Adult; Agaricales; Aged; Aged, 80 and over; A | 2016 |
Topics: AC133 Antigen; Acenaphthenes; Acer; Acrosome Reaction; Adult; Agaricales; Aged; Aged, 80 and over; A | 2016 |
Topics: AC133 Antigen; Acenaphthenes; Acer; Acrosome Reaction; Adult; Agaricales; Aged; Aged, 80 and over; A | 2016 |
A pharmacogenomic method for individualized prediction of drug sensitivity.
Topics: Animals; Biomarkers, Tumor; Breast Neoplasms; Cell Line, Tumor; Drug Resistance, Neoplasm; Female; G | 2011 |
2 trials available for valproic acid and Sensitivity and Specificity
| Article | Year |
|---|---|
9-fluorenylmethyl chloroformate as a fluorescence-labeling reagent for derivatization of carboxylic acid moiety of sodium valproate using liquid chromatography/tandem mass spectrometry for binding characterization: a human pharmacokinetic study.
Topics: Anticonvulsants; Chromatography, High Pressure Liquid; Cross-Over Studies; Fluorenes; Humans; Male; | 2012 |
Inositol augmentation of lithium or valproate for bipolar depression.
Topics: Adult; Antidepressive Agents; Antipsychotic Agents; Bipolar Disorder; Brief Psychiatric Rating Scale | 2006 |
52 other studies available for valproic acid and Sensitivity and Specificity
| Article | Year |
|---|---|
CYP2C9-mediated metabolic activation of losartan detected by a highly sensitive cell-based screening assay.
Topics: Antihypertensive Agents; Aryl Hydrocarbon Hydroxylases; Benzbromarone; Biotransformation; Cyclooxyge | 2011 |
Enhancing activity and selectivity in a series of pyrrol-1-yl-1-hydroxypyrazole-based aldose reductase inhibitors: The case of trifluoroacetylation.
Topics: Acetylation; Aldehyde Reductase; Animals; Enzyme Inhibitors; Lens, Crystalline; Pyrazoles; Pyrroles; | 2017 |
Simple determination of valproic acid serum concentrations using BioSPME followed by gas chromatography-mass spectrometric analysis.
Topics: Gas Chromatography-Mass Spectrometry; Humans; Linear Models; Reproducibility of Results; Sensitivity | 2021 |
Therapeutic drug monitoring of valproic acid using a dried plasma spot sampling device.
Topics: Biosensing Techniques; Chromatography, High Pressure Liquid; Dried Blood Spot Testing; Drug Monitori | 2021 |
Clinical Importance of Monitoring Unbound Valproic Acid Concentration in Patients with Hypoalbuminemia.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Drug Monitoring; Epilepsy; Female; Humans; Hypoalbu | 2017 |
The Negative Regulator CXXC5: Making WNT Look a Little Less Dishevelled.
Topics: Alopecia; Animals; beta Catenin; Carrier Proteins; DNA-Binding Proteins; Gene Expression Regulation; | 2017 |
Carbamazepine, lamotrigine, levetiracetam and valproic acid in dried blood spots with liquid chromatography tandem mass spectrometry; method development and validation.
Topics: Carbamazepine; Chromatography, Liquid; Dried Blood Spot Testing; Female; Humans; Lamotrigine; Leveti | 2018 |
A rapid and simple HPLC-MS/MS method for the simultaneous quantification of valproic acid and its five metabolites in human plasma and application to study pharmacokinetic interaction in Chinese epilepsy patients.
Topics: Adolescent; Adult; Anticonvulsants; Asian People; Chromatography, High Pressure Liquid; Drug Interac | 2018 |
Combine these screening tools to detect bipolar depression.
Topics: Adult; Antimanic Agents; Bipolar Disorder; Humans; Interview, Psychological; Male; Mass Screening; P | 2018 |
Valproic acid protection against the brachial plexus root avulsion-induced death of motoneurons in rats.
Topics: Analysis of Variance; Animals; Brachial Plexus; Brachial Plexus Neuropathies; Cell Death; Cells, Cul | 2013 |
Factors associated with lack of response to valproic acid monotherapy in juvenile myoclonic epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Electroencephalography; Female; Humans; Longitudinal Studies; Ma | 2014 |
Gas chromatography-electron ionization-mass spectrometry quantitation of valproic acid and gabapentin, using dried plasma spots, for therapeutic drug monitoring in in-home medical care.
Topics: Acetamides; Amines; Cyclohexanecarboxylic Acids; Dried Blood Spot Testing; Fluoroacetates; Gabapenti | 2014 |
Simultaneous analysis of 22 antiepileptic drugs in postmortem blood, serum and plasma using LC-MS-MS with a focus on their role in forensic cases.
Topics: Amines; Anticonvulsants; Carbamazepine; Chromatography, Liquid; Cyclohexanecarboxylic Acids; Drug Mo | 2014 |
A Sensitive Triple Quadrupole Liquid Chromatography Mass Spectrometric Method for the Estimation of Valproic Acid in K2EDTA Human Plasma using Furosemide as the Internal Standard.
Topics: Calibration; Chromatography, Liquid; Edetic Acid; Furosemide; Humans; Reference Standards; Reproduci | 2016 |
Comparison of LC-MS/MS vs chemiluminescent microparticle immunoassay in measuring the valproic acid concentration in plasma of epilepsy patients in a new perspective.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Cell Line; Child; Child, Preschool; Chr | 2018 |
Rapid detection of drugs in biofluids using atmospheric pressure chemi/chemical ionization mass spectrometry.
Topics: Amphetamines; Atmospheric Pressure; Humans; Ions; Ketamine; Mass Spectrometry; Models, Chemical; Ref | 2009 |
Child Mania Rating Scale-Parent Version: a valid measure of symptom change due to pharmacotherapy.
Topics: Adolescent; Antimanic Agents; Bipolar Disorder; Child; Diagnosis, Differential; Dopamine Antagonists | 2011 |
LC-MS/MS method for simultaneous determination of valproic acid and major metabolites in human plasma.
Topics: Adult; Analysis of Variance; Anticonvulsants; Chromatography, Liquid; Drug Stability; Female; Humans | 2011 |
Simple and accurate quantitative analysis of ten antiepileptic drugs in human plasma by liquid chromatography/tandem mass spectrometry.
Topics: Anticonvulsants; Calibration; Carbamazepine; Chromatography, Liquid; Drug Monitoring; Drug Stability | 2011 |
Valproic acid reversed pathologic endothelial cell gene expression profile associated with ischemia-reperfusion injury in a swine hemorrhagic shock model.
Topics: Animals; Cells, Cultured; Disease Models, Animal; Endothelial Cells; Endothelium, Vascular; Gene Exp | 2012 |
Pretreatment with valproic acid, a histone deacetylase inhibitor, enhances the sensitivity of the peripheral blood micronucleus assay in rodents.
Topics: Animals; Cyclophosphamide; Erythrocytes; Histone Deacetylase Inhibitors; Male; Methotrexate; Mice; M | 2013 |
Performance characteristics of four immunoassays for antiepileptic drugs on the IMMULITE 2000 automated analyzer.
Topics: Anticonvulsants; Carbamazepine; Chromatography, High Pressure Liquid; Cross Reactions; Drug Monitori | 2002 |
Gas chromatographic determination of novel valproyl taurinamide derivatives in mouse and dog plasma.
Topics: Animals; Chromatography, Gas; Dogs; Mass Spectrometry; Mice; Reproducibility of Results; Sensitivity | 2003 |
Activation of serum aminotransferases by pyridoxal-5' -phosphate in epileptic patients treated with anticonvulsant drugs.
Topics: Adult; Alanine Transaminase; Aspartate Aminotransferases; Carbamazepine; Drug Therapy, Combination; | 2004 |
Approach to the assessment of platelet function: comparison between optical-based platelet-rich plasma and impedance-based whole blood platelet aggregation methods.
Topics: Adolescent; Adult; Aspirin; Blood Platelets; Child; Clopidogrel; Diagnostic Tests, Routine; Electric | 2005 |
The histone deacetylase inhibitor valproic acid alters sensitivity towards all trans retinoic acid in acute myeloblastic leukemia cells.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; C | 2005 |
Simultaneous determination of mycophenolic acid and valproic acid based on derivatization by high-performance liquid chromatography with fluorescence detection.
Topics: Chromatography, High Pressure Liquid; Coumarins; Drug Stability; Humans; Mycophenolic Acid; Reproduc | 2006 |
High sensitivity determination of valproic acid in mouse plasma using semi-automated sample preparation and liquid chromatography with tandem mass spectrometric detection.
Topics: Animals; Automation; Chromatography, Liquid; Mass Spectrometry; Mice; Sensitivity and Specificity; V | 2005 |
Reliability and validity of the pathological gambling adaptation of the Yale-Brown Obsessive-Compulsive Scale (PG-YBOCS).
Topics: Adult; Disruptive, Impulse Control, and Conduct Disorders; Female; Fluvoxamine; Gambling; Humans; Li | 2005 |
Plasma clozapine levels and clinical response in treatment-refractory Chinese schizophrenic patients.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Antipsychotic Agents; China; Chromatography, High Pressure | 2006 |
Detecting vigabatrin toxicity by imaging of the retinal nerve fiber layer.
Topics: Adult; Anticonvulsants; Carbamazepine; Cross-Sectional Studies; Epilepsy; Female; Humans; Male; Nerv | 2006 |
Sub-second adsorptive fast Fourier transform coulometric technique as a novel method for the determination of nanomolar concentrations of sodium valproate in its pharmaceutical preparation in flowing solution systems.
Topics: Electrochemistry; Flow Injection Analysis; Fourier Analysis; Microchemistry; Nanotechnology; Pharmac | 2007 |
Total phenytoin concentrations do not accurately predict free phenytoin concentrations in critically ill children.
Topics: Adolescent; Adult; Anti-Bacterial Agents; Anticonvulsants; Blood Chemical Analysis; Cefazolin; Child | 2006 |
Determination of valproic acid in human serum and pharmaceutical preparations by headspace liquid-phase microextraction gas chromatography-flame ionization detection without prior derivatization.
Topics: Anticonvulsants; Chromatography, Gas; Humans; Hydrogen-Ion Concentration; Osmolar Concentration; Pha | 2007 |
Inhibition of histone deacetylase enhances the anti-proliferative action of antiestrogens on breast cancer cells and blocks tamoxifen-induced proliferation of uterine cells.
Topics: Aromatase; Breast Neoplasms; Cell Line; Cell Proliferation; Enzyme Inhibitors; Estrogen Antagonists; | 2007 |
[Determination of serum valproic acid drugs by capillary electrophoresis].
Topics: Anticonvulsants; Electrophoresis, Capillary; Epilepsy; Humans; Sensitivity and Specificity; Valproic | 2006 |
Specificity of mood stabilizer action on neuronal growth cones.
Topics: Animals; Animals, Newborn; Ganglia, Spinal; Inositol; Lithium Compounds; Psychotropic Drugs; Rats; R | 2007 |
An ImmunoChip prototype for simultaneous detection of antiepileptic drugs using an enhanced one-step homogeneous immunoassay.
Topics: Anticonvulsants; Carbamazepine; Humans; Immunoassay; Phenytoin; Reagent Kits, Diagnostic; Sensitivit | 2007 |
Response and remission in adolescent mania: signal detection analyses of the young mania rating scale.
Topics: Acute Disease; Adolescent; Antimanic Agents; Bipolar Disorder; Dibenzothiazepines; Female; Humans; M | 2007 |
Robust isocratic high performance liquid chromatographic method for simultaneous determination of seven antiepileptic drugs including lamotrigine, oxcarbazepine and zonisamide in serum after solid-phase extraction.
Topics: Analysis of Variance; Animals; Anticonvulsants; Carbamazepine; Cattle; Chromatography, High Pressure | 2007 |
Searching for a needle in a haystack: use of ICD-9-CM codes in drug-induced liver injury.
Topics: Adolescent; Adult; Aged; Amoxicillin-Potassium Clavulanate Combination; Chemical and Drug Induced Li | 2007 |
NKG2D ligand expression in AML increases in response to HDAC inhibitor valproic acid and contributes to allorecognition by NK-cell lines with single KIR-HLA class I specificities.
Topics: Cell Line; Cell Survival; Cytotoxicity, Immunologic; Enzyme Inhibitors; GPI-Linked Proteins; Histoco | 2008 |
Prevention of hypoxia-induced neuronal apoptosis through histone deacetylase inhibition.
Topics: Acetylation; Animals; Apoptosis; Blotting, Western; Caspases; Cell Survival; Cells, Cultured; Embryo | 2008 |
Determination of urinary valproylcarnitine by gas chromatography-mass spectrometry with selected-ion monitoring.
Topics: Calibration; Carbon Tetrachloride; Carnitine; Dimethylformamide; Drug Stability; Epilepsy; Gas Chrom | 1995 |
Fast atom bombardment mass spectrometry.
Topics: Animals; Benzopyrenes; Cattle; Coumaric Acids; Glycerol; Glycopeptides; Insulin; Molecular Weight; O | 1996 |
Validation of microdialysis sampling for subcutaneous extracellular valproic acid in humans.
Topics: Anticonvulsants; Chromatography, Gas; Drug Monitoring; Humans; Microdialysis; Reference Values; Sens | 1998 |
Validation of corneally kindled mice: a sensitive screening model for partial epilepsy in man.
Topics: Amygdala; Animals; Anticonvulsants; Carbamazepine; Cornea; Disease Models, Animal; Dizocilpine Malea | 1998 |
Metabolic profiling of valproic acid by cDNA-expressed human cytochrome P450 enzymes using negative-ion chemical ionization gas chromatography-mass spectrometry.
Topics: Cytochrome P-450 Enzyme System; DNA, Complementary; Gas Chromatography-Mass Spectrometry; Humans; Ki | 2000 |
Assessment of drug concentrations in tears in therapeutic drug monitoring: I. Determination of valproic acid in tears by gas chromatography/mass spectrometry with EC/NCI mode.
Topics: Anticonvulsants; Calibration; Drug Monitoring; Epilepsy; Gas Chromatography-Mass Spectrometry; Human | 2000 |
Rapid and sensitive liquid chromatographic assay of mefenamic acid in plasma.
Topics: Carbamazepine; Chromatography, Liquid; Clonazepam; Humans; Hydrogen-Ion Concentration; Indomethacin; | 1992 |
Urinary medium-chain acylcarnitines in medium-chain acyl-CoA dehydrogenase deficiency, medium-chain triglyceride feeding and valproic acid therapy: sensitivity and specificity of the radioisotopic exchange/high performance liquid chromatography method.
Topics: Acyl-CoA Dehydrogenase; Acyl-CoA Dehydrogenases; Adolescent; Carnitine; Child; Child, Preschool; Chr | 1992 |
Clinical evaluation of five therapeutic drugs using dry film multilayer technology on the OPUS immunoassay system.
Topics: Carbamazepine; Evaluation Studies as Topic; Humans; Immunoassay; Pharmaceutical Preparations; Phenob | 1991 |