valproic acid has been researched along with Seizures in 1050 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The ESETT was a prospective, double-blinded, adaptive trial evaluating levetiracetam, valproate, and fosphenytoin as second-line agents in benzodiazepine-refractory status epilepticus in adults and children." | 9.51 | Treatment of Toxin-Related Status Epilepticus With Levetiracetam, Fosphenytoin, or Valproate in Patients Enrolled in the Established Status Epilepticus Treatment Trial. ( Chamberlain, JM; Coralic, Z; Kapur, J; Olson, KR; Overbeek, D; Silbergleit, R, 2022) |
| " Patients with seizures that are treated with valproic acid (VPA) may have a decreased risk of further seizures." | 9.27 | Downregulation of microRNA‑155 by preoperative administration of valproic acid prevents postoperative seizures by upregulating SCN1A. ( Liu, Y; Wang, Z; Zhang, B; Zhang, Z, 2018) |
| "This post-hoc subgroup analysis of data from an unblinded, randomized, 52-week superiority study (KOMET) compared the effectiveness of levetiracetam (LEV) with extended-release sodium valproate (VPA-ER) and controlled-release carbamazepine (CBZ-CR) as monotherapy in patients aged ≥ 60 years with newly diagnosed epilepsy." | 9.22 | Comparative effectiveness of levetiracetam, valproate and carbamazepine among elderly patients with newly diagnosed epilepsy: subgroup analysis of the randomized, unblinded KOMET study. ( Marson, AG; Noack-Rink, M; Pohlmann-Eden, B; Ramirez, F; Tofighy, A; Trinka, E; Werhahn, KJ; Wild, I, 2016) |
| " Adults with partial-onset seizures must have been taking either carbamazepine/oxcarbazepine (CBZ/OXC), lamotrigine (LTG), levetiracetam (LEV), or valproic acid (VPA)." | 9.20 | Efficacy and safety of ezogabine/retigabine as adjunctive therapy to specified single antiepileptic medications in an open-label study of adults with partial-onset seizures. ( Brandt, C; Daniluk, J; DeRossett, S; Edwards, S; Lerche, H; Lotay, N, 2015) |
| "For a retrospective observational investigation based on real clinical practice of relative efficacy of valpoic acid (VPA), carbamazepine (CBZ) and topiramate (TPM) we have selected 106 patients with age of seizure onset before 17 years with a undoubted diagnosis of symptomatic or cryptogenic occipital lobe epilepsy (OLE), who had received treatment according to ILAE recommendations, and observation time since the last treatment change was from 2 to 10 years." | 9.14 | [Comparative efficacy of carbamazepine, valproic acid and topiramate in symptomatic and cryptogenic occipital lobe epilepsy in children]. ( , 2010) |
| "To review the evidence for the effects of ethosuximide, valproate and lamotrigine as treatments for children and adolescents with absence seizures (AS), when compared with placebo or each other." | 9.12 | Ethosuximide, sodium valproate or lamotrigine for absence seizures in children and adolescents. ( Brigo, F; Igwe, SC; Lattanzi, S, 2021) |
| "To compare topiramate (TPM) with investigator's choice of carbamazepine (CBZ) or valproate (VPA) for initial treatment in patients with newly diagnosed epilepsy." | 9.10 | Topiramate, carbamazepine and valproate monotherapy: double-blind comparison in newly diagnosed epilepsy. ( Brodie, MJ; Chadwick, DW; Mattson, RH; Neto, W; Privitera, MD; Wang, S, 2003) |
| "Warnings of L-carnitine induced seizures are recorded on product monographs and pharmacy databases, without any referenced literature." | 8.93 | Levocarnitine induced seizures in patients on valproic acid: A negative systematic review. ( Gillman, LM; Sader, N; West, M; Zeiler, FA, 2016) |
| "To review the time to withdrawal, remission and first seizure of phenytoin compared to valproate when used as monotherapy in people with partial onset seizures or generalised tonic-clonic seizures (with or without other generalised seizure types)." | 8.93 | Phenytoin versus valproate monotherapy for partial onset seizures and generalised onset tonic-clonic seizures: an individual participant data review. ( Marson, AG; Nolan, SJ; Tudur Smith, C; Weston, J, 2016) |
| "To review the best evidence comparing phenobarbitone and phenytoin when used as monotherapy in participants with partial onset seizures or generalised tonic-clonic seizures with or without other generalised seizure types." | 8.89 | Phenobarbitone versus phenytoin monotherapy for partial onset seizures and generalised onset tonic-clonic seizures. ( Marson, AG; Nolan, SJ; Pulman, J; Tudur Smith, C, 2013) |
| "To review the best evidence comparing phenytoin and valproate when used as monotherapy in individuals with partial onset seizures or generalised onset tonic-clonic seizures with or without other generalised seizure types." | 8.89 | Phenytoin versus valproate monotherapy for partial onset seizures and generalised onset tonic-clonic seizures. ( Marson, AG; Nolan, SJ; Pulman, J; Tudur Smith, C, 2013) |
| "We present a case of eosinophilic pleural effusion due to valproic acid (VPA), a rare adverse event that has been reported previously." | 8.88 | Valproic acid-induced eosinophilic pleural effusion: a case report and review of the literature. ( Da'as, N; Esayag, Y; Kamenetsky, Z; Kleinman, Y; Samuels, N, 2012) |
| " We review the clinical literature which suggests that tolerance can develop to most treatment approaches in bipolar illness and present an animal model of tolerance development to anticonvulsant effects of carbamazepine or lamotrigine on amgydala-kindled seizures." | 8.87 | Tolerance to the prophylactic effects of carbamazepine and related mood stabilizers in the treatment of bipolar disorders. ( Post, RM; Weiss, SR, 2011) |
| "To review the best evidence comparing phenytoin and valproate when used as monotherapy in subjects with partial onset seizures, or generalized onset tonic-clonic seizures with or without other generalized seizure types." | 8.81 | Phenytoin versus valproate monotherapy for partial onset seizures and generalized onset tonic-clonic seizures. ( Marson, AG; Tudur Smith, C; Williamson, PR, 2001) |
| "We describe a case of a 31-year-old woman with cerebral palsy who developed fatal acute hemorrhagic pancreatitis while being treated with valproic acid to control her seizure activity." | 8.79 | Fatal acute pancreatitis caused by valproic acid. ( Evans, RJ; Jordan, J; Krolikowski, FJ; Miranda, RN, 1995) |
| "Resistance to valproic acid (VPA) is a major challenge for epilepsy treatment." | 8.31 | Overexpression of Homer1b/c induces valproic acid resistance in epilepsy. ( Li, Y; Li, Z; Lu, J; Wang, G; Wang, Y, 2023) |
| "To investigate the efficacy and mechanisms of Dingxian pill combined with valproic acid (VPA) on pentylenetetrazol-induced chronical epilepsy in rats." | 8.31 | Efficacy and mechanisms of Dingxian pill combined with valproic acid on pentylenetetrazol-induced chronic epilepsy in rats. ( Dongxiao, QU; Guoyi, LI; Jie, T; Jiwei, C; Liji, C; Limin, Z; Qian, X; Yiqin, GE; Yonghua, X; Yudan, Z, 2023) |
| "Valproic acid (VPA) is a relatively safe drug widely used for the treatment of epileptic seizures and mania in bipolar disorder, as well as the prevention of migraine headaches." | 8.31 | Acute pancreatitis during valproic acid administration in a patient with vascular dementia, epileptic seizures, and psychiatric symptoms: a case report. ( Harada, M; Hashimoto, R; Igata, R; Ikenouchi, A; Isomoto, N; Konishi, Y; Okamoto, N; Shinkai, T; Yanaga, M; Yoshimura, R, 2023) |
| " Previously a significant anticonvulsant potential of cardiac glycoside digoxin has been verified by enhancing a weak activity of AEDs in low doses under screening models of seizures induced by pentylenetetrazole and maximal electroshock." | 8.12 | Digoxin at sub-cardiotonic dose modulates the anticonvulsive potential of valproate, levetiracetam and topiramate in experimental primary generalized seizures. ( Mishchenko, M; Shtrygol, D; Shtrygol, S; Tsyvunin, V, 2022) |
| " Here we examine the effects of valproic acid (VA) plus 4-phenylbutyric acid (4-PBA) on abnormal electrical brain activity, ER stress and apoptosis in acute seizures induced by pentylenetetrazole (PTZ)." | 8.12 | 4-Phenylbutyric Acid Plus Valproic Acid Exhibits the Therapeutic and Neuroprotective Effects in Acute Seizures Induced by Pentylenetetrazole. ( Amanvermez, R; Arslan, G; Gün, S; Rzayev, E; Tiryaki, ES, 2022) |
| "AbstractThe aim of this study was to explore the effect of lamotrigine (LTG) on blood ammonia level in patients with epilepsy and identify risk factors affecting blood ammonia level." | 8.12 | Risk factors of elevated blood ammonia level in epilepsy patients treated with lamotrigine. ( Chen, J; Chen, X; Chen, Y; Miao, J; Wang, R; Zeng, J; Zhuang, X, 2022) |
| "Valproic acid (VPA) represents one of the most efficient antiseizure medications (ASMs) for both general and focal seizures, but some patients may have inadequate control by VPA monotherapy." | 8.12 | Neural excitatory rebound induced by valproic acid may predict its inadequate control of seizures. ( Chen, L; Cui, Z; Guo, Y; Jiang, S; Ke, Z; Liu, Y; Mao, Y; Tong, Y; Wang, D; Wu, Z; Zhang, H; Zhu, Z; Zou, X, 2022) |
| "A retrospective chart review conducted at King Abdulaziz University Hospital, Jeddah, Kingdome of Saudi Arabia, for children below 2 years of age diagnosed with epilepsy and treated with valproic acid from January 2016 to January 2020." | 8.02 | Valproic acid for children below 2 years of age with epilepsy. ( Alfawaz, NS; Almahmudi, SM; Alrabghi, MO; Bin Mahfouz, MM; Muthaffar, OY, 2021) |
| " In the pharmacodynamic interaction study, seizures were induced using pentylenetetrazole (PTZ) (60 mg/kg, i." | 8.02 | Pharmacodynamic and pharmacokinetic interactions of hydroalcoholic leaf extract of Centella asiatica with valproate and phenytoin in experimental models of epilepsy in rats. ( Agarwal, A; Arora, R; Ganeshan N, S; Gupta, YK; Kaleekal, T; Kumar, R; Sarangi, SC, 2021) |
| "This study aimed at estimating the cumulative incidence of antiepileptic drug (AED) treatment failure of first-line monotherapy levetiracetam vs valproic acid in glioma patients with epilepsy." | 8.02 | First-line antiepileptic drug treatment in glioma patients with epilepsy: Levetiracetam vs valproic acid. ( Dirven, L; Fiocco, M; Koekkoek, JAF; Kouwenhoven, MCM; Taphoorn, MJB; van den Bent, MJ; van der Meer, PB; Vos, MJ, 2021) |
| "This study was carried out to determine changes over time in use of folic acid, anti-epileptic drugs (AED), seizures during pregnancy and malformation rate over two decades in women with epilepsy enrolled in the Kerala registry of Epilepsy and Pregnancy (KREP)." | 7.96 | Anti-epileptic drug and folic acid usage during pregnancy, seizure and malformation outcomes: Changes over two decades in the Kerala Registry of Epilepsy and Pregnancy. ( A S, R; Baishya, J; Jose, M; Keni, RR; Sankara Sarma, P; Thomas, SV, 2020) |
| "The goal of our study was to examine the long-term effect of vigabatrin (VGB), a γ-aminobutyric acid aminotransferase (GABA-AT) inhibitor on clonazepam (CLO), ethosuximide (ETX) and valproate (VPA) anticonvulsive activity against pentylenetetrazole (PTZ)-induced seizures in mice." | 7.96 | Long-term vigabatrin treatment modifies pentylenetetrazole-induced seizures in mice: focused on GABA brain concentration. ( Czuczwar, SJ; Krzyżanowski, M; Świąder, K; Świąder, MJ; Wróbel, A; Zakrocka, I; Łuszczki, JJ, 2020) |
| "Clinicians should use caution interpreting lamotrigine levels when working up delirium, as normal levels may not rule out the development of lamotrigine toxicity." | 7.96 | Delirium Secondary to Lamotrigine Toxicity. ( Catalano, G; Catalano, MC; Fusick, AJ; Gunther, SR; Hernandez, MJ; Sanchez, DL; Sullivan, GA, 2020) |
| "Here, we present a multicenter series of patients with developmental and epileptic encephalopathies (DEE) and related electroclinical patterns (REP) other than Lennox-Gastaut syndrome (LGS) who were treated with rufinamide as add-on therapy." | 7.96 | Rufinamide as add-on therapy in children with epileptic encephalopathies other than Lennox-Gastaut syndrome: A study of 34 patients. ( Caraballo, RH; Espeche, A; Fasulo, L; Galichio, S; Pociecha, J; Reyes, G; Semprino, M, 2020) |
| " A 13-year-old girl with genetically confirmed Pitt-Hopkins syndrome with uncontrolled seizures, while on treatment with levetiracetam and valproic acid, was started on perampanel, reaching seizure control." | 7.91 | Perampanel-induced hair curling in a patient with epilepsy associated with Pitt Hopkins syndrome. ( Calle-Lopez, Y; Knight, EP; Kotagal, P, 2019) |
| "The objective of this study was to evaluate the long-term safety, tolerability, and efficacy of cannabidiol in children with epilepsy." | 7.91 | Long-Term Safety, Tolerability, and Efficacy of Cannabidiol in Children with Refractory Epilepsy: Results from an Expanded Access Program in the US. ( Caminha Nunes, E; Cilio, MR; Oldham, MS; Rahdari, S; Sands, TT; Tilton, N, 2019) |
| "This study aims to describe the associations between genetic polymorphisms and therapeutic effect of valproic acid (VPA) in children with focal seizures." | 7.91 | Lack of association between valproic acid response and polymorphisms of its metabolism, transport, and receptor genes in children with focal seizures. ( Fang, F; Feng, W; Gao, B; Han, J; Li, J; Mei, S; Wu, Y; Yu, Y; Zhao, Z; Zhu, L, 2019) |
| "The use of losartan with sodium valproate in epilepsy may prevent the cognitive and cardiac sequelae of seizures." | 7.91 | Effects of enalapril and losartan alone and in combination with sodium valproate on seizures, memory, and cardiac changes in rats. ( Arava, S; Gupta, YK; Joshi, D; Katyal, J, 2019) |
| "Anticonvulsant administration is the standard of care for prevention of busulfan-induced seizures (BIS) in hematopoietic stem cell transplantation (HSCT)." | 7.91 | Comparison of valproate and levetiracetam for the prevention of busulfan-induced seizures in hematopoietic stem cell transplantation. ( Fukuda, T; Hashimoto, H; Inamoto, Y; Ito, A; Kim, SW; Koido, K; Kurosawa, S; Nakashima, T; Nishibuchi, Y; Tanaka, T; Terakado, H, 2019) |
| " At day 58 after birth, oral high-dose phenobarbital therapy was introduced which resulted in the suppression of seizures to one or two per week and disappearance of the burst-suppression pattern on EEG." | 7.91 | A case of early myoclonic encephalopathy with intractable seizures successfully treated with high-dose phenobarbital. ( Kawatani, M; Kometani, H; Kosaka, T; Ohshima, Y; Ohta, G, 2019) |
| " This case report describes a 28-year-old male presenting status-post multiple tonic-clonic seizures, treated for persistent seizure activity refractory to benzodiazepines with valproic acid (VPA), levetiracetam, and fosphenytoin." | 7.88 | A cool side effect of valproic acid administration: Single dose-induced hypothermia. ( Priano, J; Schiel, J; Servati, N; Vilar, J, 2018) |
| "High-dose valproic acid combined with hypothermic-targeted temperature management prevents postcardiac arrest seizures and improves survival." | 7.85 | Valproic Acid Combined With Postcardiac Arrest Hypothermic-Targeted Temperature Management Prevents Delayed Seizures and Improves Survival in a Rat Cardiac Arrest Model. ( Neumar, RW; Oh, JS; Stacey, WC; Tulasi, J; Xiaodan, R, 2017) |
| "CYT-evoked alterations in the protection provided by some antiepileptic drugs against seizures can be of serious concern for epileptic smokers, who might demonstrate therapeutic failure to lacosamide, levetiracetam, and pregabalin, resulting in possible breakthrough seizure attacks." | 7.85 | Cytisine inhibits the protective activity of various classical and novel antiepileptic drugs against 6 Hz-induced psychomotor seizures in mice. ( Florek-Łuszczki, M; Kondrat-Wróbel, MW; Tutka, P; Zaluska, K; Żółkowska, D; Łuszczki, JJ, 2017) |
| "A 12-year-old boy with intractable epilepsy had tonic and atonic seizures despite treatment with valproic acid (3000mg/day), levetiracetam (3000mg/day) and clobazam (40mg/day)." | 7.83 | Aggravation of atonic seizures by rufinamide: A case report. ( Aydın, A; Aydınlı, N; Bektaş, G; Çalışkan, M; Özmen, M; Pembegül Yıldız, E; Tatlı, B, 2016) |
| " Here, we suggest that triggering limbic seizures with low doses of PTZ in pilocarpine-treated marmosets might provide a more effective basis for the development of AED." | 7.83 | Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment. ( Blanco, MM; Cinini, SM; Lima, TZ; Mello, LE; Pontes, JC; Queiroz, CM, 2016) |
| "Valproic acid (VPA) is a widely used antiepileptic drug with acceptable safety and efficacy in treating pediatric patients with various kinds of seizures." | 7.83 | Effects of UGT1A6 and GABRA1 on Standardized Valproic Acid Plasma Concentrations and Treatment Effect in Children With Epilepsy in China. ( Fang, F; Feng, W; Gao, B; Mei, S; Wu, X; Yang, W; Yu, Y; Zhao, Z; Zhu, L, 2016) |
| "A patient presented with convulsive seizures when sodium valproate (VPA) and tebipenem pivoxil (Orapenem) were co-administered accidentally." | 7.81 | First case report of suspected onset of convulsive seizures due to co-administration of valproic acid and tebipenem. ( Miki, A; Nakamoto, N; Satoh, H; Sawada, Y; Shihyakugari, A, 2015) |
| "Lacosamide (LCM), a new antiepileptic drug (AED) approved as adjunctive therapy for the treatment of patients with partial-onset seizures, has limited pharmacokinetic and drug interaction data." | 7.80 | Lacosamide serum concentrations in adult patients with epilepsy: the influence of gender, age, dose, and concomitant antiepileptic drugs. ( Duncan, JS; Markoula, S; Patsalos, PN; Ratnaraj, N; Sander, JW; Teotonio, R, 2014) |
| "Levetiracetam (LEV), used for both partial and generalized seizures, is a frequently preferred antiepileptic because of its few side effects." | 7.80 | Hypokalemia and hypomagnesaemia related to levetiracetam use. ( Aksoy, D; Cevik, B; Kurt, S; Pekdas, E; Solmaz, V, 2014) |
| "Valproic acid (VA) is an antiepileptic drug (AED) and histone deacetylase (HDAC) inhibitor taken by patients with glioblastoma (GB) to manage seizures, and it can modulate the biologic effects of radiation therapy (RT)." | 7.79 | Valproic acid use during radiation therapy for glioblastoma associated with improved survival. ( Barker, CA; Beal, K; Bishop, AJ; Chan, TA; Chang, M, 2013) |
| "To examine the efficacy of valproic acid (VPA) given either with or without levetiracetam (LEV) on seizure control and on survival in patients with glioblastoma multiforme (GBM) treated with chemoradiation." | 7.79 | Effect of valproic acid on seizure control and on survival in patients with glioblastoma multiforme. ( Dielemans, JC; Kerkhof, M; Taphoorn, MJ; van Breemen, MS; Vecht, CJ; Walchenbach, R; Zwinkels, H, 2013) |
| " (MQ) in maximal electroshock (MES) and pentylenetetrazole (PTZ) induced rat models of epilepsy." | 7.79 | Evaluation of anti-epileptic property of Marsilea quadrifolia Linn. in maximal electroshock and pentylenetetrazole-induced rat models of epilepsy. ( Avinash, H; Chandrashekar, BR; Mukunda, N; Naduvil Narayanan, S; Nayak, BS; Raghavendra Rao, K; Sadhana, N; Satish Kumar, MC; Snehunsu, A; Vijay Kapgal, K, 2013) |
| " Using the prenatal valproic acid (VPA)-injection model of autism spectrum disorder (ASD) in rats, which produces social impairrment and altered seizure susceptibility as in human ASD patients as well as mild neural tube defects like crooked tail phenotype, we examined whether chronic administration of red ginseng extract may rescue the social impairment and crooked tail phenotype in prenatally VPA-exposed rat offspring." | 7.79 | Effects of Korean red ginseng extracts on neural tube defects and impairment of social interaction induced by prenatal exposure to valproic acid. ( Han, SH; Kim, HJ; Kim, HY; Kim, KC; Kim, P; Kwon, KJ; Lee, JM; Park, JH; Shin, CY, 2013) |
| " Previous work demonstrated the convulsive and widespread neuropathological effects of soman, an organophosphorus compound that causes SE and severe recurrent seizures as a result of exposure." | 7.78 | Combined diazepam and HDAC inhibitor treatment protects against seizures and neuronal damage caused by soman exposure. ( Addis, M; Bailey, K; Chanda, S; de Araujo Furtado, M; Lumley, LA; Moffett, M; Pak, T; Robertson, BD; Rossetti, F; Shields, M; Yourick, DL, 2012) |
| " MET test (PTZ at the dose of 70 mg/kg) acute seizures in Wistar rats, in comparison to valproic acid (VPA)." | 7.76 | Levetiracetam in submaximal subcutaneous pentylentetrazol-induced seizures in rats. ( Arcieri, S; Coppola, G; D'Aniello, A; Messana, T; Pascotto, A; Signoriello, G; Verrotti, A, 2010) |
| "Pioglitazone, a peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonist, is used in inflammatory brain diseases, and it was shown to protect against seizures in genetically epileptic mice." | 7.76 | Anticonvulsant potential of the peroxisome proliferator-activated receptor γ agonist pioglitazone in pentylenetetrazole-induced acute seizures and kindling in mice. ( Abdallah, DM, 2010) |
| " We studied the potential anticonvulsant effect of thalidomide: Different doses of thalidomide were tested against seizures induced by 50 mg/kg or 70 mg/kg of pentylenetetrazole (PTZ); the anticonvulsant effect of thalidomide was also compared with that of valproic acid." | 7.74 | Thalidomide inhibits pentylenetetrazole-induced seizures. ( Calderon, A; Palencia, G; Sotelo, J, 2007) |
| " The combination of AGLD (5 mg/kg) with phenobarbital (PB, applied at its subeffective dose of 15 mg/kg) significantly shortened motor seizure and afterdischarge duration in amygdala-kindled seizures." | 7.73 | Aminoglutethimide but not spironolactone enhances the anticonvulsant effect of some antiepileptics against amygdala-kindled seizures in rats. ( Borowicz, KK; Czuczwar, SJ, 2005) |
| "To report a probable interaction between meropenem and valproic acid that resulted in the development of epileptic seizures." | 7.73 | Acute seizures due to a probable interaction between valproic acid and meropenem. ( Borrás-Blasco, J; Coves-Orts, FJ; Murcia-López, A; Navarro-Ruiz, A; Palacios-Ortega, F, 2005) |
| " He had been obese, had been receiving a standard dose of valproic acid since clipping surgery for subarachnoid hemorrhage 17 years previously, and had not consumed any alcohol since the surgery." | 7.73 | Hepatocellular carcinoma and nonalcoholic steatohepatitis developing during long-term administration of valproic acid. ( Iizuka, H; Katsuda, S; Okamoto, K; Sato, K; Ueda, Y; Ueno, K, 2005) |
| "Isobolographic analysis was used to characterize the interactions between loreclezole (LCZ) and clonazepam (CZP), ethosuximide (ETS), phenobarbital (PB), and valproate (VPA) in suppressing pentylenetetrazole (PTZ)-induced seizures and in producing acute neurotoxic adverse effects in the chimney test in mice so as to identify optimum combinations." | 7.73 | Pharmacodynamic and/or pharmacokinetic characteristics of interactions between loreclezole and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice: an isobolographic analysis. ( Czuczwar, SJ; Luszczki, JJ; Patsalos, PN; Ratnaraj, N, 2005) |
| "We report on a 4-year 8-month-old boy with Panayiotopoulos syndrome who showed atypical evolution with newly developed absence seizures and EEG exacerbation induced by carbamazepine." | 7.73 | EEG and seizure exacerbation induced by carbamazepine in Panayiotopoulos syndrome. ( Akiyama, T; Endoh, F; Ito, M; Kikumoto, K; Ohtsuka, Y; Oka, M; Yoshinaga, H, 2006) |
| "In the present study, the mechanism behind flurothyl-induced seizures was examined using drugs acting on the GABA-benzodiazepine receptor complex in Mongolian gerbils." | 7.73 | Effects of drugs acting on the GABA-benzodiazepine receptor complex on flurothyl-induced seizures in Mongolian gerbils. ( Araki, H; Gomita, Y; Hashimoto, Y; Suemaru, K, 2006) |
| " Pentylenetetrazole (PTZ)-induced seizures were used to evaluate the anticonvulsant effect of drugs." | 7.73 | Modulation of pentylenetetrazole-induced seizures and oxidative stress parameters by sodium valproate in the absence and presence of N-acetylcysteine. ( Pillai, KK; Uma Devi, P; Vohora, D, 2006) |
| " Anticonvulsant effects were evaluated against seizures induced by 14 mg kg(-1) of 4-aminopyridine (4-AP) and by 110 mg kg(-1) of pentylenetetrazole (PTZ), and neurotoxicity by the rotarod test." | 7.72 | Is the interaction between felbamate and valproate against seizures induced by 4-aminopyridine and pentylenetetrazole in mice beneficial? ( Amat, G; Armijo, JA; Cuadrado, A, 2003) |
| " The aim of this study was to evaluate the profile of interactions between FBM and four conventional antiepileptic drugs (AEDs): clonazepam (CZP), ethosuximide (ESM), phenobarbital (PB), and valproate (VPA), in pentylenetetrazole (PTZ)-induced convulsions in mice, a model of myoclonic seizures in humans." | 7.72 | Isobolographic and subthreshold analysis of interactions among felbamate and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice. ( Borowicz, KK; Czuczwar, SJ; Luszczki, JJ, 2004) |
| " Alphaxalone (up to 5 mg/kg) did not exert a significant action against amygdala-kindled seizures in rats, or against pentetrazole- or aminophylline-induced convulsions in mice." | 7.71 | Interaction of the neurosteroid alphaxalone with conventional antiepileptic drugs in different types of experimental seizures. ( Borowicz, KK; Czuczwar, SJ; Kleinrok, Z; Kowalska, A; Swiader, M; Zadrozniak, M, 2002) |
| " Anticonvulsant effects were evaluated against seizures induced by both 4-aminopyridine and pentylenetetrazole, and neurotoxic effects were evaluated by the rotarod test." | 7.71 | Synergistic interaction between valproate and lamotrigine against seizures induced by 4-aminopyridine and pentylenetetrazole in mice. ( Armijo, JA; Cuadrado, A; de las Cuevas, I; Valdizán, EM, 2002) |
| "We present a patient with early infantile epileptic encephalopathy with suppression bursts (Ohtahara syndrome) with an excellent response to chloral hydrate to draw attention to a possible role of the "old" drug in the treatment of intractable epilepsy." | 7.71 | Successful treatment of Ohtahara syndrome with chloral hydrate. ( Komárek, V; Krsek, P; Maulisová, A; Procházka, T; Sebronová, V, 2002) |
| "A 14-year-old child treated with valproic acid over several years for a seizure disorder developed abdominal pain with radiological evidence of acute pancreatitis." | 7.71 | A case of chronic pancreatic insufficiency due to valproic acid in a child. ( Cooper, MA; Groll, A, 2001) |
| "Molsidomine (25 mg kg(-1)), a donor of nitric oxide, commonly used in the treatment of coronary artery disease, enhanced the protective activity of valproate against the clonic phase of pentylenetetrazole-induced seizures in mice, significantly reducing the ED(50) of valproate from 123." | 7.71 | Molsidomine enhances the protective activity of valproate against pentylenetetrazole-induced seizures in mice. ( Arent, K; Kleinrok, Z; Tutka, P; Wielosz, M; Łuszczki, J, 2002) |
| "The authors herein present two children with mild absence epilepsy, having intermittent absences, who developed absence status evolving into atonic generalized seizures and drop attacks along with progressive disorientation induced by relatively small doses of valproic acid." | 7.71 | Valproic acid therapy inducing absence status evolving into generalized seizures. ( Andraus, J; Sagie-Lerman, T; Savitzki, D; Shahar, E, 2002) |
| "The efficacy of Flunarizine (FLU), a calcium channel blocker, in combination with conventional antiepileptic drugs, phenytoin (PHT), carbamazepine (CBZ), sodium valproate (VPA), and ethosuximide (ESM), at ED50 doses, were examined for protective effects against maximal electroshock seizures (MES) and pentylenetetrazol (PTZ) induced seizures in mice." | 7.70 | Additive anticonvulsant effect of flunarizine and sodium valproate on electroshock and chemoshock induced seizures in mice. ( David, J; Joseph, S; Joseph, T, 1998) |
| "The activity of nimodipine and nitrendipine against pentylenetetrazole (PTZ) induced seizures in Albino rats was studied alone and in combination with valproate." | 7.70 | Anticonvulsant profile of nimodipine and nitrendipine against pentylenetetrazole induced seizures in rats. ( Balakrishnan, S; Bhargava, VK; Pandhi, P, 1999) |
| "The effects of GABAmimetic drugs on inhibition of amygdaloid kindled seizures induced by clobenpropit were investigated to clarify the relationship between histaminergic and GABAergic systems in seizures." | 7.70 | Participation of GABAergic and histaminergic systems in inhibiting amygdaloid kindled seizures. ( Chen, Z; Fujii, Y; Ishizawa, K; Kamei, C; Okuma, C; Sugimoto, Y, 2000) |
| "Perimenstrual catamenial epilepsy, the exacerbation of seizures in association with menstruation, may in part be due to withdrawal of the progesterone metabolite allopregnanolone (3alpha-hydroxy-5alpha-pregnan-20-one), an endogenous anticonvulsant neurosteroid that is a positive allosteric modulator of gamma-aminobutyric acid(A) receptors." | 7.70 | Enhanced anticonvulsant activity of ganaxolone after neurosteroid withdrawal in a rat model of catamenial epilepsy. ( Reddy, DS; Rogawski, MA, 2000) |
| "We report a case of stroke in a child with acquired protein C deficiency receiving valproic acid (VPA)." | 7.70 | Protein C deficiency related to valproic acid therapy: a possible association with childhood stroke. ( Balasa, V; Degrauw, A; Fogelson, H; Gartside, P; Glauser, T; Gruppo, R, 2000) |
| "The charts of 55 patients receiving clozapine and valproate concurrently between May 8, 1989, and May 8, 1992, were reviewed to determine the indication for and length of time on each medication, abnormalities in liver function test results, blood cell dyscrasias, seizures, nausea, vomiting, sedation, sialorrhea, and enuresis." | 7.69 | Concurrent use of clozapine and valproate in affective and psychotic disorders. ( Castillo, J; Centorrino, F; Kando, JC; Tohen, M, 1994) |
| "An epileptic patient well controlled on valproic acid (VPA) developed a prolonged episode of status epilepticus 12 days after initiation of 75 mg of clomipramine (CMI) to treat depression." | 7.69 | Status epilepticus associated with the combination of valproic acid and clomipramine. ( DeToledo, JC; Haddad, H; Ramsay, RE, 1997) |
| " The interaction of theophylline and the antiepileptic drugs diazepam and sodium valproate was studied in pentylenetetrazole (PTZ) - kindled seizures in rats." | 7.69 | Effect of theophylline on diazepam and sodium valproate protection in pentylenetetrazole - kindled seizures in rats. ( Gupta, YK; Malhotra, J, 1997) |
| "We report on a 33-year-old female suffering from frequent complex-partial seizures who developed a non-convulsive status epilepticus after one week of antiepileptic therapy with valproate (VPA) which had been added to a basic medication with barbexaclone (BBC) in rapidly increasing dosage." | 7.68 | Temporary abolition of seizure activity by flumazenil in a case of valproate-induced non-convulsive status epilepticus. ( Steinhoff, BJ; Stodieck, SR, 1993) |
| "Immature rats are more susceptible to clonic seizures induced by aminooxyacetic acid (AOAA) than mature and senile rats." | 7.68 | Age dependency of the susceptibility of rats to aminooxyacetic acid seizures. ( Cavalheiro, EA; Dziki, M; Kleinrok, Z; Parada, J; Turski, W, 1992) |
| "A 5-year-old child receiving valproic acid syrup for seizure control developed diarrhea probably from the excipient ingredients." | 7.68 | Excipients in valproic acid syrup may cause diarrhea: a case report. ( Veerman, MW, 1990) |
| "The anticonvulsant potency of 2-propyl-2-pentenoic acid (2-en-VPA; trans isomer), a major metabolite of the antiepileptic valproic acid (VPA), was evaluated in different animal models of epilepsy and compared with the respective data for VPA." | 7.67 | Comparative evaluation of anticonvulsant and toxic potencies of valproic acid and 2-en-valproic acid in different animal models of epilepsy. ( Löscher, W; Marescaux, C; Nau, H; Vergnes, M, 1984) |
| "Glutamic acid diethyl ester (GDEE) is a glutamate antagonist which acts preferentially at the quisqualate-sensitive receptor and has been shown to be an effective anticonvulsant in alcohol withdrawal and homocysteine-induced seizures but ineffective in other seizure models." | 7.67 | Inhibition of quisqualate-induced seizures by glutamic acid diethyl ester and anti-epileptic drugs. ( Freed, WJ; Schwarz, SS, 1986) |
| "Six neonates with prolonged, intractable seizures were treated with valproic acid (VPA)." | 7.67 | Valproic acid efficacy, toxicity, and pharmacokinetics in neonates with intractable seizures. ( Gal, P; Gilman, JT; Oles, KS; Weaver, R, 1988) |
| "Amino acid concentrations were measured in the cortex, cerebellum and hippocampus of the mouse brain before and during seizures induced by isoniazid (250 mg/kg i." | 7.67 | The specific protective effect of diazepam and valproate against isoniazid-induced seizures is not correlated with increased GABA levels. ( Baltzer, V; Bernasconi, R; Jones, RS; Klein, M; Maître, L; Martin, P; Portet, C; Schmutz, M, 1985) |
| "The effect of valproic acid and 10 close analogues (7 branched and 3 non-branched) were studied on the content of gamma-aminobutyric acid (GABA) in brain and on seizures induced by pentylenetetrazol (PTZ) in mice." | 7.66 | The effects of analogues of valproic acid on seizures induced by pentylenetetrazol and GABA content in brain of mice. ( Keane, PE; Mendes, E; Morre, M; Santucci, V; Simiand, J, 1983) |
| "The anticonvulsant activity of the ethyl esters of the major valproic acid metabolites was assessed against minimal pentylenetetrazol seizures in adult male ICR mice." | 7.66 | Effects of ethyl ester derivatives of valproic acid metabolites on pentylenetetrazol seizures in mice. ( Bruni, J; Hammond, EJ; Wilder, BJ, 1981) |
| "Primary outcome was seizure cessation for 1h, and secondary outcomes were 24h seizure remission, in-hospital death, and severe adverse events (SAE)." | 6.84 | Comparison of lacosamide versus sodium valproate in status epilepticus: A pilot study. ( Dubey, D; Kalita, J; Misra, UK, 2017) |
| "Epileptic myoclonus or myoclonic seizures can occur in idiopathic generalized epilepsy (IGE) and progressive myoclonus epilepsy (PME)." | 6.82 | A systematic review of the efficacy of perampanel as treatment for myoclonic seizures and symptomatic myoclonus ( Albaradie, R; Alghamdi, A; Alotaibi, M; Alotaibi, W; Bashir, S; Mir, A; Samreen, D, 2022) |
| " However, these medications have several well-known adverse effects." | 6.77 | Efficacy and safety of intravenous sodium valproate versus phenobarbital in controlling convulsive status epilepticus and acute prolonged convulsive seizures in children: a randomised trial. ( Ashrafi, MR; Bavarian, B; Ghaempanah, M; Khosroshahi, N; Malamiri, RA; Nikkhah, A, 2012) |
| " Patients were converted during an | 6.71 | Lamotrigine monotherapy compared with carbamazepine, phenytoin, or valproate monotherapy in patients with epilepsy. ( Hammer, AE; Kaminow, L; Schimschock, JR; Vuong, A, 2003) |
| " A major challenge lies in the lack of knowledge about the bioavailability and pharmacodynamic effects of bioactive compounds in this model organism." | 5.91 | Pharmacometabolic Effects of Pteryxin and Valproate on Pentylenetetrazole-Induced Seizures in Zebrafish Reveal Vagus Nerve Stimulation. ( Budzyńska, B; Gertsch, J; Kozioł, E; Lee, SM; Morozova, V; Pellegata, D; Skalicka-Woźniak, K; Skiba, A, 2023) |
| " Hence, reducing VPA dosage to minimize side effects while maintaining its efficacy is necessary, and transcranial photobiomodulation (tPBM) add-on therapy could facilitate this." | 5.72 | Transcranial photobiomodulation add-on therapy to valproic acid for pentylenetetrazole-induced seizures in peripubertal rats. ( Chang, H; Chang, SF; Tsai, CM, 2022) |
| "Valproic acid (VPA) is an antiepileptic drug, used for focal and generalized seizure." | 5.72 | The impact of valproic acid treatment on weight gain in pediatric patients with epilepsy. ( Battaglia, D; Blasi, V; DI Ruscio, F; Ferrara, P; Gatto, A, 2022) |
| "Fenfluramine (FFA), an antiseizure medication (ASM) indicated for treating convulsive seizures in Dravet syndrome, was assessed in six patients (five female; 83%) with CDD whose seizures had failed 5-12 ASMs or therapies." | 5.62 | Effect of fenfluramine on convulsive seizures in CDKL5 deficiency disorder. ( Conway, E; Devinsky, O; King, L; Price, D; Schwartz, D, 2021) |
| "Levetiracetam (LEV) is a second-generation antiseizure medicine (ASM) with broad-spectrum efficacy and tolerability." | 5.62 | Initial levetiracetam versus valproate monotherapy in antiseizure medicine (ASM)-naïve pediatric patients with idiopathic generalized epilepsy with tonic-clonic seizures. ( Abdelmesih, SK; Elkhateeb, N; Girgis, MY; Zakaria, M, 2021) |
| "Carbamazepine was ineffective, and seizures were exacerbated with levetiracetam (LEV)." | 5.56 | Improvement of epilepsy with lacosamide in a patient with ring chromosome 20 syndrome. ( Goji, A; Kagami, S; Mori, T; Tayama, T; Toda, Y, 2020) |
| " This study investigated the effect of delayed or missed doses on the pharmacokinetics (PK) of valproic acid (VPA) in patients with epilepsy and established remedial dosing recommendations for nonadherent patients." | 5.56 | Remedial dosing recommendations for delayed or missed doses of valproic acid in patients with epilepsy based on Monte Carlo simulations. ( Ding, JJ; Jiao, Z; Wang, CY; Yu, EQ; Zhu, GX, 2020) |
| "The ESETT was a prospective, double-blinded, adaptive trial evaluating levetiracetam, valproate, and fosphenytoin as second-line agents in benzodiazepine-refractory status epilepticus in adults and children." | 5.51 | Treatment of Toxin-Related Status Epilepticus With Levetiracetam, Fosphenytoin, or Valproate in Patients Enrolled in the Established Status Epilepticus Treatment Trial. ( Chamberlain, JM; Coralic, Z; Kapur, J; Olson, KR; Overbeek, D; Silbergleit, R, 2022) |
| "Olanzapine is a second-generation antipsychotic." | 5.51 | Generalised tonic-clonic seizures on the subtherapeutic dose of olanzapine. ( Chachar, AS; Mansoor, M; Mesiya, MH, 2019) |
| "Epileptic seizures are frequent in patients with glioblastoma, and anticonvulsive treatment is often necessary." | 5.51 | AMPA receptor antagonist perampanel affects glioblastoma cell growth and glutamate release in vitro. ( Bergner, C; Hörnschemeyer, J; Kirschstein, T; Köhling, R; Krause, BJ; Lange, F; Linnebacher, M; Mullins, CS; Porath, K; Weßlau, K, 2019) |
| "Curcumin is a phytochemical with promising effects on epilepsy treatment." | 5.48 | Micronization potentiates curcumin's anti-seizure effect and brings an important advance in epilepsy treatment. ( Aguiar, GPS; Bertoncello, KT; Oliveira, JV; Siebel, AM, 2018) |
| "Carnitine is a commonly used antidote for acute intoxication of valproic acid, but is not a therapeutic option for management of chronic adults with adverse effects related to valproic acid." | 5.46 | L-Carnitine supplementation to reverse hyperammonemia in a patient undergoing chronic valproic acid treatment: A case report. ( Fagiolino, P; Guevara, N; Maldonado, C; Silveira, A; Vázquez, M, 2017) |
| "We evaluated the occurrence of seizures in 450 consecutive high-dose BZD dependence patients admitted to our unit from April 2012 to April 2016 for detoxification with low-dose slow subcutaneous infusion of flumazenil associated with routine anticonvulsant prophylaxis." | 5.46 | Low risk of seizures with slow flumazenil infusion and routine anticonvulsant prophylaxis for high-dose benzodiazepine dependence. ( Bongiovanni, LG; Casari, R; Faccini, M; Federico, A; Franchini, E; Lugoboni, F; Morbioli, L; Tamburin, S, 2017) |
| "Recently, the use of acute seizure tests in epileptic rats or mice has been proposed as a novel strategy for evaluating novel AEDs for increased antiseizure efficacy." | 5.43 | Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures. ( Löscher, W; Töllner, K; Twele, F, 2016) |
| " Haematological toxicity is a limiting side effect of both, first line radio-chemotherapy with temozolomide (TMZ) and co-medication with antiepileptic drugs." | 5.42 | Haematological toxicity of Valproic acid compared to Levetiracetam in patients with glioblastoma multiforme undergoing concomitant radio-chemotherapy: a retrospective cohort study. ( Geroldinger, A; Gleiss, A; Grisold, W; Marosi, C; Moser, W; Oberndorfer, S; Sax, C; Sherif, C; Tinchon, A, 2015) |
| "Valproic acid treated animals were treated from 5 days preceding behavioral testing in the Morris water maze at a clinically relevant concentration." | 5.42 | Standard dose valproic acid does not cause additional cognitive impact in a rodent model of intractable epilepsy. ( Jellett, AP; Jenks, K; Lucas, M; Scott, RC, 2015) |
| "Recurrent seizures requiring either emergency room (ER) visits or hospitalization were used to measure the efficacy of seizure control." | 5.42 | Efficacy of phenytoin, valproic acid, carbamazepine and new antiepileptic drugs on control of late-onset post-stroke epilepsy in Taiwan. ( Chan, L; Chi, NF; Chien, LN; Chiou, HY; Hu, CJ; Huang, YH; Kuan, YC, 2015) |
| " As adjunctive therapies, topiramate ranked best for GTCA as well as overall for IGEs, while levetiracetam ranked best for myoclonic seizures." | 5.41 | Antiseizure medications for idiopathic generalized epilepsies: a systematic review and network meta-analysis. ( Chu, H; Shi, J; Yang, X; Zhang, X; Zhou, Z, 2023) |
| "The incidence of seizures, their expression pattern and their latencies were registered and the severity was expressed by means of a five-point scale." | 5.39 | Derivatives of valproic acid are active against pentetrazol-induced seizures in immature rats. ( Bialer, M; Hen, N; Kubová, H; Mareš, P; Yagen, B, 2013) |
| "This retrospective study compared the seizure outcomes, side effects and durability of levetiracetam with valproic acid after a craniotomy for supratentorial brain tumors." | 5.39 | Levetiracetam compared with valproic acid for the prevention of postoperative seizures after supratentorial tumor surgery: a retrospective chart review. ( Bae, SH; Han, JH; Kim, CY; Kim, T; Kim, YH; Lee, YJ; Yun, CH, 2013) |
| "Vagus nerve stimulation prevents seizures by continuously activating noradrenergic projections from the brainstem to the cortex." | 5.39 | Closed-loop neural stimulation for pentylenetetrazole-induced seizures in zebrafish. ( Beattie, CE; Hall, CW; Pineda, R, 2013) |
| "Valproic acid (VPA) has been reported to cause cognitive decline and parkinsonism that are reversed with cessation of medication." | 5.37 | Reversible dementia and gait disturbance after prolonged use of valproic acid. ( Evans, MD; Shinar, R; Yaari, R, 2011) |
| " Plasma concentrations (pc), interactions between drugs in the ICU context, adverse effects and seizure occurrences were observed and recorded." | 5.37 | Levetiracetam compared to valproic acid: plasma concentration levels, adverse effects and interactions in aneurysmal subarachnoid hemorrhage. ( Bjeljac, M; Keller, E; Mink, S; Muroi, C; Seule, M, 2011) |
| "Clonic seizures were rare in NMDA-treated P25 rats, but valproate pretreatment increased their incidence significantly." | 5.36 | Vigabatrin but not valproate prevents development of age-specific flexion seizures induced by N-methyl-D-aspartate (NMDA) in immature rats. ( Kubová, H; Mares, P, 2010) |
| "Ertapenem was discontinued, and his divalproex sodium dosage was increased further." | 5.34 | Acute seizures in a patient receiving divalproex sodium after starting ertapenem therapy. ( Lunde, JL; Nelson, RE; Storandt, HF, 2007) |
| "Using an amygdala-kindled seizure paradigm, we evaluated the acute and chronic anticonvulsant effects of lamotrigine (LTG)." | 5.31 | Tolerance to the anticonvulsant effects of lamotrigine on amygdala kindled seizures: cross-tolerance to carbamazepine but not valproate or diazepam. ( Heynen, T; Krupp, E; Li, XL; Post, RM; Weiss, SR, 2000) |
| "In MES seizures significant protection was seen with aspirin 100 mg/kg where as higher dose of aspirin 500 mg/kg was required to elicit maximum protection against PTZ seizures." | 5.31 | Aspirin modulates the anticonvulsant effect of diazepam and sodium valproate in pentylenetetrazole and maximal electroshock induced seizures in mice. ( Gupta, YK; Srivastava, AK, 2001) |
| "Add-on cannabidiol (CBD) significantly reduced seizures associated with Dravet syndrome (DS) in a randomized, double-blind, placebo-controlled trial: GWPCARE1 Part B (NCT02091375)." | 5.30 | Long-term cannabidiol treatment in patients with Dravet syndrome: An open-label extension trial. ( Devinsky, O; Laux, L; Miller, I; Nabbout, R; Roberts, C; Wright, S; Zolnowska, M, 2019) |
| "In the maximal electroshock seizure threshold test, clobenpropit dose-dependently raised the electroconvulsive threshold for tonic (hindlimb extension) seizures, but a significant increase of about 15% was determined only at the high dose of 40 mg/kg i." | 5.30 | Effect of clobenpropit, a centrally acting histamine H3-receptor antagonist, on electroshock- and pentylenetetrazol-induced seizures in mice. ( Fischer, W; van der Goot, H, 1998) |
| "Myoclonus and seizures disappeared after discontinuation of L-dopa and the introduction of valproate sodium (VPA)." | 5.29 | Myoclonus and seizures in a patient with parkinsonism: induction by levodopa and its confirmation on SEPs. ( Hamada, T; Matsuura, T; Moriwaka, F; Tashiro, K; Yoshida, K, 1993) |
| "Behavior, seizures, death, EEGs, and ECGs were observed and measured." | 5.28 | Cocaine-induced respiratory depression and seizures are synergistic mechanisms of cocaine-induced death in rats. ( Albertson, TE; Derlet, RW; Tseng, CC, 1992) |
| "Seizures were repetitive and death occurred in 10." | 5.28 | Antiepileptic drugs delay the onset of seizures induced by aminophylline in conscious rats. ( David, J; Joseph, T; Kulkarni, C, 1992) |
| " Patients with seizures that are treated with valproic acid (VPA) may have a decreased risk of further seizures." | 5.27 | Downregulation of microRNA‑155 by preoperative administration of valproic acid prevents postoperative seizures by upregulating SCN1A. ( Liu, Y; Wang, Z; Zhang, B; Zhang, Z, 2018) |
| "QUIN seizures showed particular sensitivity to carbamazepine (5 mg/kg) but were resistant to diphenylhydantoin unless a relatively high dose was used (100 mg/kg)." | 5.27 | Anticonvulsant drugs effective against human temporal lobe epilepsy prevent seizures but not neurotoxicity induced in rats by quinolinic acid: electroencephalographic, behavioral and histological assessments. ( Samanin, R; Tullii, M; Vezzani, A; Wu, HQ, 1986) |
| "Clonazepam was ineffective in treating the seizures and, in high doses, seemed to exacerbate the porphyria." | 5.26 | Seizure management in acute hepatic porphyria: risks of valproate and clonazepam. ( Bonkowsky, HL; Emery, S; Sinclair, JF; Sinclair, PR, 1980) |
| "The time to seizures was increased nearly five times by clonazepam and over three times by very small amounts of propylene glycol." | 5.26 | Protection from oxygen-induced seizures by clonazepam and propylene glycol. ( Beckman, DL; Crittenden, DJ, 1981) |
| "Isoniazid is a useful chemical convulsant in that metabolic events associated with the preseizure state can be easily examined." | 5.26 | Isoniazid induced seizures and cerebral cortical and cerebellar energy metabolism. ( Abel, MS; McCandless, DW; Schwartzenburg, FC, 1982) |
| " Potential add-on AEDs in case of uncontrolled seizures include lacosamide, perampanel, and valproic acid." | 5.22 | Management of epilepsy in brain tumor patients. ( Koekkoek, JAF; Taphoorn, MJB; van der Meer, PB, 2022) |
| "Based on low quality evidence, phenobarbital appears to be the most effective agent for seizure cessation within 60 min of administration in patients with benzodiazepine resistant status epilepticus." | 5.22 | Treatment of benzodiazepine-resistant status epilepticus: Systematic review and network meta-analyses. ( Aneja, S; Arya, R; Cunningham, J; Jain, P; Sharma, S, 2022) |
| "This article will review the different therapeutic options for status, from early treatment at home to the different first-line (benzodiazepines), second-line (phenobarbital, valproic acid, phenytoin, levetiracetam and lacosamide) or third-line treatments, which include both pharmacological (anaesthetics, propofol, ketamine, lidocaine, topiramate, brivaracetam or perampanel) and non-pharmacological (ketogenic diet, immunomodulatory treatments or epilepsy surgery) therapies." | 5.22 | [Paediatric status epilepticus]. ( García-Peñas, JJ; González-Alguacil, E; Soto-Insuga, V, 2022) |
| "This post-hoc subgroup analysis of data from an unblinded, randomized, 52-week superiority study (KOMET) compared the effectiveness of levetiracetam (LEV) with extended-release sodium valproate (VPA-ER) and controlled-release carbamazepine (CBZ-CR) as monotherapy in patients aged ≥ 60 years with newly diagnosed epilepsy." | 5.22 | Comparative effectiveness of levetiracetam, valproate and carbamazepine among elderly patients with newly diagnosed epilepsy: subgroup analysis of the randomized, unblinded KOMET study. ( Marson, AG; Noack-Rink, M; Pohlmann-Eden, B; Ramirez, F; Tofighy, A; Trinka, E; Werhahn, KJ; Wild, I, 2016) |
| " Adults with partial-onset seizures must have been taking either carbamazepine/oxcarbazepine (CBZ/OXC), lamotrigine (LTG), levetiracetam (LEV), or valproic acid (VPA)." | 5.20 | Efficacy and safety of ezogabine/retigabine as adjunctive therapy to specified single antiepileptic medications in an open-label study of adults with partial-onset seizures. ( Brandt, C; Daniluk, J; DeRossett, S; Edwards, S; Lerche, H; Lotay, N, 2015) |
| "To explore the efficacy and safety of the combined therapy of valproic acid (VPA) and lamotrigine (LTG) for various types of epilepsy." | 5.16 | [Efficacy and safety of the combined therapy of valproic acid and lamotrigine for epileptics]. ( Hu, Q; Kang, HC; Li, X; Liu, XY; Liu, ZG; Wang, M; Xu, F; Zeng, Z; Zhu, SQ, 2012) |
| " The purpose of our study was to assess the occurrence of seizures and neurologic outcome in SICH patients who were treated with valproic acid or a placebo for a period of one month and follow-up of one year in a hospital inpatient neurologic department and ambulatory clinic settings." | 5.15 | Are post intracerebral hemorrhage seizures prevented by anti-epileptic treatment? ( Boaz, M; Dabby, R; Gilad, R; Lampl, Y; Sadeh, M, 2011) |
| "For a retrospective observational investigation based on real clinical practice of relative efficacy of valpoic acid (VPA), carbamazepine (CBZ) and topiramate (TPM) we have selected 106 patients with age of seizure onset before 17 years with a undoubted diagnosis of symptomatic or cryptogenic occipital lobe epilepsy (OLE), who had received treatment according to ILAE recommendations, and observation time since the last treatment change was from 2 to 10 years." | 5.14 | [Comparative efficacy of carbamazepine, valproic acid and topiramate in symptomatic and cryptogenic occipital lobe epilepsy in children]. ( , 2010) |
| " For efficacy, a greater proportion of participants in the topiramate group had a 50% or greater reduction in primarily generalized tonic-clonic seizures (PGTCS), compared with participants in the placebo group (RR 4." | 5.12 | Topiramate for juvenile myoclonic epilepsy. ( Liu, J; Tai, YJ; Wang, LN, 2021) |
| "To review the evidence for the effects of ethosuximide, valproate and lamotrigine as treatments for children and adolescents with absence seizures (AS), when compared with placebo or each other." | 5.12 | Ethosuximide, sodium valproate or lamotrigine for absence seizures in children and adolescents. ( Brigo, F; Igwe, SC; Lattanzi, S, 2021) |
| " As part of a large double-blind, placebo-controlled clinical trial evaluating the use of valproic acid for prophylaxis of post-traumatic seizures, we obtained extensive valproic acid concentration-time data." | 5.12 | Effect of time, injury, age and ethanol on interpatient variability in valproic acid pharmacokinetics after traumatic brain injury. ( Anderson, GD; Awan, AB; Temkin, NR; Winn, HR; Winn, RH, 2007) |
| "The intravenous application of VPA seems to be an easy-to-use, safe and efficient formulation as an alternative to phenytoin in all seizure emergency situations including status epilepticus." | 5.11 | Intravenous valproate as an innovative therapy in seizure emergency situations including status epilepticus--experience in 102 adult patients. ( Peters, CN; Pohlmann-Eden, B, 2005) |
| "To compare topiramate (TPM) with investigator's choice of carbamazepine (CBZ) or valproate (VPA) for initial treatment in patients with newly diagnosed epilepsy." | 5.10 | Topiramate, carbamazepine and valproate monotherapy: double-blind comparison in newly diagnosed epilepsy. ( Brodie, MJ; Chadwick, DW; Mattson, RH; Neto, W; Privitera, MD; Wang, S, 2003) |
| " One hundred thirty-two patients at high risk for seizures were assigned to receive a 1-week course of phenytoin, 120 were assigned to receive a 1-month course of valproate, and 127 were assigned to receive a 6-month course of valproate." | 5.09 | Valproate therapy for prevention of posttraumatic seizures: a randomized trial. ( Anderson, GD; Awan, A; Cohen, W; Dikmen, SS; Holmes, MD; Nelson, P; Newell, DW; Temkin, NR; Wilensky, AJ; Winn, HR, 1999) |
| "Twenty patients with acute repetitive seizures received 20 mg/kg loading doses of valproic acid." | 5.09 | The safety of rapid valproic acid infusion. ( Faught, E; Limdi, NA, 2000) |
| "We illustrate several key methods in a real IPD-MA, where IPD of 1225 participants from 5 randomized clinical trials were combined to compare the effects of Carbamazepine and Valproate on the incidence of epileptic seizures." | 5.05 | Individual participant data meta-analysis of intervention studies with time-to-event outcomes: A review of the methodology and an applied example. ( de Jong, VMT; Debray, TPA; Eijkemans, MJC; Marson, AG; Moons, KGM; Riley, RD; Tudur Smith, C, 2020) |
| " The administration of two antiepileptic drugs, Sodium Valproate and Clonazepam, reduces significantly seizures occurrence compared with unmedicated controls." | 5.05 | [DPA and clonazepam activity in febrile convulsions: preliminary results]. ( Florio, C; Sorge, F; Steardo, L; Steardo, R, 1980) |
| "Under the medicine treatment of magnesium valproate with carbamazepine, the patient experienced partial seizures approximately once per month that lasted 30 to 60 seconds each without any complications observed during a follow-up period of 24 months." | 5.01 | A potential cause of adolescent onset Dyke-Davidoff-Masson syndrome: A case report. ( Jiang, Z; Li, B; Li, J; Li, Y; Wang, L; Zhang, T, 2019) |
| " For efficacy, a greater proportion of participants in the topiramate group had a 50% or more reduction in primarily generalized tonic-clonic seizures (PGTCS) compared with participants in the placebo group." | 5.01 | Topiramate for juvenile myoclonic epilepsy. ( Liu, J; Wang, LN; Wang, YP, 2019) |
| " The treatment of choice for CAE with absence seizures only is ethosuximide." | 5.01 | A Practical Guide to Treatment of Childhood Absence Epilepsy. ( Kessler, SK; McGinnis, E, 2019) |
| "To review the time to treatment failure, remission and first seizure of sodium valproate compared to phenytoin when used as monotherapy in people with focal onset seizures or generalised tonic-clonic seizures (with or without other generalised seizure types)." | 4.98 | Sodium valproate versus phenytoin monotherapy for epilepsy: an individual participant data review. ( Marson, AG; Nevitt, SJ; Tudur Smith, C; Weston, J, 2018) |
| " For efficacy, a greater proportion of participants in the topiramate group had a 50% or more reduction in primarily generalized tonic-clonic seizures (PGTCS) compared with participants in the placebo group." | 4.95 | Topiramate monotherapy for juvenile myoclonic epilepsy. ( Liu, J; Wang, LN; Wang, YP, 2017) |
| "Warnings of L-carnitine induced seizures are recorded on product monographs and pharmacy databases, without any referenced literature." | 4.93 | Levocarnitine induced seizures in patients on valproic acid: A negative systematic review. ( Gillman, LM; Sader, N; West, M; Zeiler, FA, 2016) |
| "To review the time to withdrawal, remission and first seizure of phenytoin compared to valproate when used as monotherapy in people with partial onset seizures or generalised tonic-clonic seizures (with or without other generalised seizure types)." | 4.93 | Phenytoin versus valproate monotherapy for partial onset seizures and generalised onset tonic-clonic seizures: an individual participant data review. ( Marson, AG; Nolan, SJ; Tudur Smith, C; Weston, J, 2016) |
| " For the efficacy, a greater proportion of participants in the topiramate group had a 50% or more reduction in primarily generalized tonic-clonic seizures (PGTCS) compared with participants in the placebo group." | 4.91 | Topiramate monotherapy for juvenile myoclonic epilepsy. ( Liu, J; Wang, LN; Wang, YP, 2015) |
| "Valproic acid is approved for treatment of seizures and manic episodes of bipolar disorder, and continues to be one of the most commonly prescribed antiepileptic drugs in the world." | 4.90 | Evidence for a potential protective effect of carnitine-pantothenic acid co-treatment on valproic acid-induced hepatotoxicity. ( Felker, D; Johnson, DE; Lynn, A; Wang, S, 2014) |
| "To review the best evidence comparing phenobarbitone and phenytoin when used as monotherapy in participants with partial onset seizures or generalised tonic-clonic seizures with or without other generalised seizure types." | 4.89 | Phenobarbitone versus phenytoin monotherapy for partial onset seizures and generalised onset tonic-clonic seizures. ( Marson, AG; Nolan, SJ; Pulman, J; Tudur Smith, C, 2013) |
| "To review the best evidence comparing phenytoin and valproate when used as monotherapy in individuals with partial onset seizures or generalised onset tonic-clonic seizures with or without other generalised seizure types." | 4.89 | Phenytoin versus valproate monotherapy for partial onset seizures and generalised onset tonic-clonic seizures. ( Marson, AG; Nolan, SJ; Pulman, J; Tudur Smith, C, 2013) |
| " Following surgery, he routinely received valproic acid (VPA) to prevent seizures." | 4.89 | Valproic acid-associated low fibrinogen and delayed intracranial hemorrhage: case report and mini literature review. ( Chen, HF; Cui, QY; Jin, LJ; Li, ZY; Luo, ZY; Qin, LM; Ren, YY; Shen, HS; Tang, JQ; Wang, J; Wang, KY; Wang, ZY; Wu, TQ; Xu, LP; Yu, ZQ; Zhu, JJ, 2013) |
| "We present a case of eosinophilic pleural effusion due to valproic acid (VPA), a rare adverse event that has been reported previously." | 4.88 | Valproic acid-induced eosinophilic pleural effusion: a case report and review of the literature. ( Da'as, N; Esayag, Y; Kamenetsky, Z; Kleinman, Y; Samuels, N, 2012) |
| " We review the clinical literature which suggests that tolerance can develop to most treatment approaches in bipolar illness and present an animal model of tolerance development to anticonvulsant effects of carbamazepine or lamotrigine on amgydala-kindled seizures." | 4.87 | Tolerance to the prophylactic effects of carbamazepine and related mood stabilizers in the treatment of bipolar disorders. ( Post, RM; Weiss, SR, 2011) |
| "03 mmol/kg for the induction of seizures), produced a significant reduction in the anticonvulsant effects of carbamazepine, phenobarbital, phenytoin, and valproate against maximal electroshock-induced seizures in mice." | 4.84 | [Caffeine and antiepileptic drugs: experimental and clinical data]. ( Błaszczyk, B; Chrościńska-Krawczyk, M; Czuczwar, SJ; Jankiewicz, K, 2007) |
| "No evidence supports AED prophylaxis with phenobarbital, phenytoin, or valproic acid in patients with brain tumors and no history of seizures, regardless of neoplastic type." | 4.82 | Seizure prophylaxis in patients with brain tumors: a meta-analysis. ( Drazkowski, JF; Lyons, MK; Sirven, JI; Wingerchuk, DM; Zimmerman, RS, 2004) |
| "To review the best evidence comparing phenytoin and valproate when used as monotherapy in subjects with partial onset seizures, or generalized onset tonic-clonic seizures with or without other generalized seizure types." | 4.81 | Phenytoin versus valproate monotherapy for partial onset seizures and generalized onset tonic-clonic seizures. ( Marson, AG; Tudur Smith, C; Williamson, PR, 2001) |
| " Key search terms included HIV, AIDS, seizures, valproic acid, and glutathione." | 4.80 | The use of valproic acid in HIV-positive patients. ( Jennings, HR; Romanelli, F, 1999) |
| "We describe a case of a 31-year-old woman with cerebral palsy who developed fatal acute hemorrhagic pancreatitis while being treated with valproic acid to control her seizure activity." | 4.79 | Fatal acute pancreatitis caused by valproic acid. ( Evans, RJ; Jordan, J; Krolikowski, FJ; Miranda, RN, 1995) |
| " We describe the phenomenon of amygdala-kindled seizures episodically breaking through effective daily pharmacotherapy with carbamazepine and valproate, suggesting that these observations could reflect the balance of pathological vs compensatory illness-induced changes in gene expression." | 4.79 | A speculative model of affective illness cyclicity based on patterns of drug tolerance observed in amygdala-kindled seizures. ( Post, RM; Weiss, SR, 1996) |
| "Resistance to valproic acid (VPA) is a major challenge for epilepsy treatment." | 4.31 | Overexpression of Homer1b/c induces valproic acid resistance in epilepsy. ( Li, Y; Li, Z; Lu, J; Wang, G; Wang, Y, 2023) |
| " The aim of this study was to determine the anticonvulsant profiles of scoparone (a simple coumarin) and borneol (a bicyclic monoterpenoid) when administered separately and in combination, as well as their impact on the antiseizure effects of four classic ASMs (carbamazepine, phenytoin, phenobarbital and valproate) in the mouse model of maximal electroshock-induced (MES) tonic-clonic seizures." | 4.31 | Antiseizure Effects of Scoparone, Borneol and Their Impact on the Anticonvulsant Potency of Four Classic Antiseizure Medications in the Mouse MES Model-An Isobolographic Transformation. ( Bojar, H; Góralczyk, A; Skalicka-Woźniak, K; Łuszczki, JJ, 2023) |
| "To investigate the efficacy and mechanisms of Dingxian pill combined with valproic acid (VPA) on pentylenetetrazol-induced chronical epilepsy in rats." | 4.31 | Efficacy and mechanisms of Dingxian pill combined with valproic acid on pentylenetetrazol-induced chronic epilepsy in rats. ( Dongxiao, QU; Guoyi, LI; Jie, T; Jiwei, C; Liji, C; Limin, Z; Qian, X; Yiqin, GE; Yonghua, X; Yudan, Z, 2023) |
| "Valproic acid (VPA) is a relatively safe drug widely used for the treatment of epileptic seizures and mania in bipolar disorder, as well as the prevention of migraine headaches." | 4.31 | Acute pancreatitis during valproic acid administration in a patient with vascular dementia, epileptic seizures, and psychiatric symptoms: a case report. ( Harada, M; Hashimoto, R; Igata, R; Ikenouchi, A; Isomoto, N; Konishi, Y; Okamoto, N; Shinkai, T; Yanaga, M; Yoshimura, R, 2023) |
| "Use of valproate and carbamazepine decreased progressively, use of lamotrigine remained relatively static, and the use of levetiracetam increased progressively, whereas the use of topiramate first increased and then fell again, associated with a temporary increase in malformation-associated pregnancy rate." | 4.31 | Changes over 24 years in a pregnancy register - Teratogenicity and epileptic seizure control. ( Eadie, M; Graham, J; Hitchcock, A; Lander, C; O'Brien, T; Perucca, P; Vajda, F, 2023) |
| " In our case series, lamotrigine proved to be less effective and less controllable than other drugs during pregnancy." | 4.12 | [Women with epilepsy before and during pregnancy: a case series of outpatient counseling in a tertiary epilepsy center]. ( Bien, CG; Hagemann, A; Knaak, N; Müffelmann, B, 2022) |
| " Previously a significant anticonvulsant potential of cardiac glycoside digoxin has been verified by enhancing a weak activity of AEDs in low doses under screening models of seizures induced by pentylenetetrazole and maximal electroshock." | 4.12 | Digoxin at sub-cardiotonic dose modulates the anticonvulsive potential of valproate, levetiracetam and topiramate in experimental primary generalized seizures. ( Mishchenko, M; Shtrygol, D; Shtrygol, S; Tsyvunin, V, 2022) |
| " Here we examine the effects of valproic acid (VA) plus 4-phenylbutyric acid (4-PBA) on abnormal electrical brain activity, ER stress and apoptosis in acute seizures induced by pentylenetetrazole (PTZ)." | 4.12 | 4-Phenylbutyric Acid Plus Valproic Acid Exhibits the Therapeutic and Neuroprotective Effects in Acute Seizures Induced by Pentylenetetrazole. ( Amanvermez, R; Arslan, G; Gün, S; Rzayev, E; Tiryaki, ES, 2022) |
| "AbstractThe aim of this study was to explore the effect of lamotrigine (LTG) on blood ammonia level in patients with epilepsy and identify risk factors affecting blood ammonia level." | 4.12 | Risk factors of elevated blood ammonia level in epilepsy patients treated with lamotrigine. ( Chen, J; Chen, X; Chen, Y; Miao, J; Wang, R; Zeng, J; Zhuang, X, 2022) |
| "Valproic acid (VPA) represents one of the most efficient antiseizure medications (ASMs) for both general and focal seizures, but some patients may have inadequate control by VPA monotherapy." | 4.12 | Neural excitatory rebound induced by valproic acid may predict its inadequate control of seizures. ( Chen, L; Cui, Z; Guo, Y; Jiang, S; Ke, Z; Liu, Y; Mao, Y; Tong, Y; Wang, D; Wu, Z; Zhang, H; Zhu, Z; Zou, X, 2022) |
| " In this study, the effect of antidepressant sertraline (SRT) in combination with AEDs sodium valproate (SV) and levetiracetam (LEV) on seizures, cognitive impairment and oxidative stress in rats was evaluated." | 4.02 | Response to sertraline and antiepileptic drugs in pentylenetetrazole kindling in rats. ( Hussain, M; Katyal, J; Rashid, H, 2021) |
| "A retrospective chart review conducted at King Abdulaziz University Hospital, Jeddah, Kingdome of Saudi Arabia, for children below 2 years of age diagnosed with epilepsy and treated with valproic acid from January 2016 to January 2020." | 4.02 | Valproic acid for children below 2 years of age with epilepsy. ( Alfawaz, NS; Almahmudi, SM; Alrabghi, MO; Bin Mahfouz, MM; Muthaffar, OY, 2021) |
| " Therefore, the present study hypothesized an antiepileptic potential of chondroitin sulfate (CS) in pentylenetetrazole-induced kindled epilepsy and pilocarpine-induced status epilepticus in mice." | 4.02 | Anticonvulsive Effects of Chondroitin Sulfate on Pilocarpine and Pentylenetetrazole Induced Epileptogenesis in Mice. ( Abdel-Daim, MM; Almeer, R; Kamel, M; Najda, A; Nurzyńska-Wierdak, R; Singh, M; Singh, S; Singh, TG, 2021) |
| " In the pharmacodynamic interaction study, seizures were induced using pentylenetetrazole (PTZ) (60 mg/kg, i." | 4.02 | Pharmacodynamic and pharmacokinetic interactions of hydroalcoholic leaf extract of Centella asiatica with valproate and phenytoin in experimental models of epilepsy in rats. ( Agarwal, A; Arora, R; Ganeshan N, S; Gupta, YK; Kaleekal, T; Kumar, R; Sarangi, SC, 2021) |
| " In this study, we examined the effect of both acute and chronic treatment with moclobemide on seizures and the action of first-generation antiepileptic drugs: valproate, carbamazepine, phenobarbital and phenytoin." | 4.02 | Acute and chronic treatment with moclobemide, a reversible MAO-inhibitor, potentiates the antielectroshock activity of conventional antiepileptic drugs in mice. ( Banach, M; Borowicz-Reutt, KK, 2021) |
| " Exanthema as especially clinically relevant adverse drug event was rightly chosen for carbamazepine by 18 (8%) and for lamotrigine by 12 (5%) participants." | 4.02 | Knowledge of epilepsy among German pharmacists. ( Bertsche, A; Bertsche, T; Herziger, B; Jeschke, S; Müller, RM; Neininger, MP, 2021) |
| "This study aimed at estimating the cumulative incidence of antiepileptic drug (AED) treatment failure of first-line monotherapy levetiracetam vs valproic acid in glioma patients with epilepsy." | 4.02 | First-line antiepileptic drug treatment in glioma patients with epilepsy: Levetiracetam vs valproic acid. ( Dirven, L; Fiocco, M; Koekkoek, JAF; Kouwenhoven, MCM; Taphoorn, MJB; van den Bent, MJ; van der Meer, PB; Vos, MJ, 2021) |
| "Nearly half the children with breakthrough seizures had sub-therapeutic levels, especially those on phenytoin therapy." | 4.02 | Antiseizure Drug Levels in Children Aged 2-12 Years Presenting With Breakthrough Seizures: A Single Center Cross-sectional Study. ( Aggarwal, A; Garg, R; Malhotra, R; Narang, M; Sharma, S, 2021) |
| " Importantly, the isobolographic analysis showed that a combination of AS-1 and valproic acid (VPA) at the fixed ratio of 1:1 displayed a supra-additive (synergistic) interaction against PTZ-induced seizures in mice." | 3.96 | N-Benzyl-(2,5-dioxopyrrolidin-1-yl)propanamide (AS-1) with Hybrid Structure as a Candidate for a Broad-Spectrum Antiepileptic Drug. ( Abram, M; Andres-Mach, M; Esguerra, CV; Gawel, K; Jakubiec, M; Kamiński, K; Latacz, G; Lubelska, A; Nieoczym, D; Pieróg, M; Rapacz, A; Socała, K; Szewczyk, A; Szulczyk, B; Wlaź, P; Zagaja, M; Łuszczki, JJ, 2020) |
| "This study was carried out to determine changes over time in use of folic acid, anti-epileptic drugs (AED), seizures during pregnancy and malformation rate over two decades in women with epilepsy enrolled in the Kerala registry of Epilepsy and Pregnancy (KREP)." | 3.96 | Anti-epileptic drug and folic acid usage during pregnancy, seizure and malformation outcomes: Changes over two decades in the Kerala Registry of Epilepsy and Pregnancy. ( A S, R; Baishya, J; Jose, M; Keni, RR; Sankara Sarma, P; Thomas, SV, 2020) |
| "The goal of our study was to examine the long-term effect of vigabatrin (VGB), a γ-aminobutyric acid aminotransferase (GABA-AT) inhibitor on clonazepam (CLO), ethosuximide (ETX) and valproate (VPA) anticonvulsive activity against pentylenetetrazole (PTZ)-induced seizures in mice." | 3.96 | Long-term vigabatrin treatment modifies pentylenetetrazole-induced seizures in mice: focused on GABA brain concentration. ( Czuczwar, SJ; Krzyżanowski, M; Świąder, K; Świąder, MJ; Wróbel, A; Zakrocka, I; Łuszczki, JJ, 2020) |
| "Clinicians should use caution interpreting lamotrigine levels when working up delirium, as normal levels may not rule out the development of lamotrigine toxicity." | 3.96 | Delirium Secondary to Lamotrigine Toxicity. ( Catalano, G; Catalano, MC; Fusick, AJ; Gunther, SR; Hernandez, MJ; Sanchez, DL; Sullivan, GA, 2020) |
| "Here, we present a multicenter series of patients with developmental and epileptic encephalopathies (DEE) and related electroclinical patterns (REP) other than Lennox-Gastaut syndrome (LGS) who were treated with rufinamide as add-on therapy." | 3.96 | Rufinamide as add-on therapy in children with epileptic encephalopathies other than Lennox-Gastaut syndrome: A study of 34 patients. ( Caraballo, RH; Espeche, A; Fasulo, L; Galichio, S; Pociecha, J; Reyes, G; Semprino, M, 2020) |
| "This study was conducted to explore the influence of genetic variations on responsiveness to valproic acid (VPA) monotherapy among Chinese children with epilepsy." | 3.96 | Effects of SCN1A and SCN2A polymorphisms on responsiveness to valproic acid monotherapy in epileptic children. ( Du, Z; Liu, M; Mao, J; Wang, J; Xu, H; Xu, Q; Zhao, P, 2020) |
| " In addition, Salubrinal, an ER stress inhibitor, was used as a positive control, and exhibited neuroprotective effects via inhibiting excessive ER stress in the seizure model, which further supported that the inhibition in ER stress by VPA treatment could exert neuroprotection in seizures." | 3.91 | Sodium Valproate Reduces Neuronal Apoptosis in Acute Pentylenetetrzole-Induced Seizures via Inhibiting ER Stress. ( Chen, TC; Chen, Y; Fu, J; He, H; Peng, L; Wang, W; Zeng, S, 2019) |
| " A 13-year-old girl with genetically confirmed Pitt-Hopkins syndrome with uncontrolled seizures, while on treatment with levetiracetam and valproic acid, was started on perampanel, reaching seizure control." | 3.91 | Perampanel-induced hair curling in a patient with epilepsy associated with Pitt Hopkins syndrome. ( Calle-Lopez, Y; Knight, EP; Kotagal, P, 2019) |
| " This study evaluated the efficacy of sodium valproate encapsulated in nanoparticles in pentylenetetrazole (PTZ) induced acute and kindling models of seizures in male Wistar rats." | 3.91 | Evaluation of sodium valproate loaded nanoparticles in acute and chronic pentylenetetrazole induced seizure models. ( Dinda, AK; Gupta, YK; Kottarath, SK; Meenu, M; Reeta, KH, 2019) |
| "The objective of this study was to evaluate the long-term safety, tolerability, and efficacy of cannabidiol in children with epilepsy." | 3.91 | Long-Term Safety, Tolerability, and Efficacy of Cannabidiol in Children with Refractory Epilepsy: Results from an Expanded Access Program in the US. ( Caminha Nunes, E; Cilio, MR; Oldham, MS; Rahdari, S; Sands, TT; Tilton, N, 2019) |
| "This study aims to describe the associations between genetic polymorphisms and therapeutic effect of valproic acid (VPA) in children with focal seizures." | 3.91 | Lack of association between valproic acid response and polymorphisms of its metabolism, transport, and receptor genes in children with focal seizures. ( Fang, F; Feng, W; Gao, B; Han, J; Li, J; Mei, S; Wu, Y; Yu, Y; Zhao, Z; Zhu, L, 2019) |
| "The use of losartan with sodium valproate in epilepsy may prevent the cognitive and cardiac sequelae of seizures." | 3.91 | Effects of enalapril and losartan alone and in combination with sodium valproate on seizures, memory, and cardiac changes in rats. ( Arava, S; Gupta, YK; Joshi, D; Katyal, J, 2019) |
| "Anticonvulsant administration is the standard of care for prevention of busulfan-induced seizures (BIS) in hematopoietic stem cell transplantation (HSCT)." | 3.91 | Comparison of valproate and levetiracetam for the prevention of busulfan-induced seizures in hematopoietic stem cell transplantation. ( Fukuda, T; Hashimoto, H; Inamoto, Y; Ito, A; Kim, SW; Koido, K; Kurosawa, S; Nakashima, T; Nishibuchi, Y; Tanaka, T; Terakado, H, 2019) |
| " At day 58 after birth, oral high-dose phenobarbital therapy was introduced which resulted in the suppression of seizures to one or two per week and disappearance of the burst-suppression pattern on EEG." | 3.91 | A case of early myoclonic encephalopathy with intractable seizures successfully treated with high-dose phenobarbital. ( Kawatani, M; Kometani, H; Kosaka, T; Ohshima, Y; Ohta, G, 2019) |
| " Pentylenetetrazole- (PTZ) and pilocarpine-induced seizures are well-established models of human epilepsy." | 3.91 | The effect of co-administration of pentylenetetrazole with pilocarpine: New modified PTZ models of kindling and seizure. ( Jand, A; Mousavi-Hasanzadeh, M; Palizvan, MR; Rezaeian-Varmaziar, H; Shafaat, O, 2019) |
| " Pregabalin, valproic acid and levetiracetam all terminate seizures in the rat SE model and attenuate cholinergic and metabolic changes within two hours." | 3.91 | Effects of Three Anti-Seizure Drugs on Cholinergic and Metabolic Activity in Experimental Status Epilepticus. ( Imran, I; Klein, J; Koch, K; Lau, H; Schöfer, H, 2019) |
| " Eighty-four male Balb/C mice were divided into 7 groups: control-naïve, pentylenetetrazole (PTZ)-induced seizures, PTZ-calcitonin, PTZ-valproic acid, PTZ-pregabalin, PTZ-calcitonin-valproic acid (PCV) combination, and PTZ-calcitonin-pregabalin (PCP) combination." | 3.88 | Calcitonin potentiates the anticonvulsant and antinociceptive effects of valproic acid and pregabalin in pentylenetetrazole-kindled mice. ( Ashour, RH; El-Beltagi, HM; Hamada, NM; Shalaby, AA, 2018) |
| " The frequency of number of seizures/week was higher in the carbamazepine cohort compared to valproic acid cohort." | 3.88 | Carbamazepine Verses Valproic Acid as Monotherapy in Epileptic Patients. ( Ali, N; Nazish, H; Shakir, S, 2018) |
| " This case report describes a 28-year-old male presenting status-post multiple tonic-clonic seizures, treated for persistent seizure activity refractory to benzodiazepines with valproic acid (VPA), levetiracetam, and fosphenytoin." | 3.88 | A cool side effect of valproic acid administration: Single dose-induced hypothermia. ( Priano, J; Schiel, J; Servati, N; Vilar, J, 2018) |
| "High-dose valproic acid combined with hypothermic-targeted temperature management prevents postcardiac arrest seizures and improves survival." | 3.85 | Valproic Acid Combined With Postcardiac Arrest Hypothermic-Targeted Temperature Management Prevents Delayed Seizures and Improves Survival in a Rat Cardiac Arrest Model. ( Neumar, RW; Oh, JS; Stacey, WC; Tulasi, J; Xiaodan, R, 2017) |
| "Sotalol as a drug blocking β-receptors and potassium KCNH2 channels may interact with different substances that affect seizures." | 3.85 | Sotalol enhances the anticonvulsant action of valproate and diphenylhydantoin in the mouse maximal electroshock model. ( Banach, M; Borowicz-Reutt, KK; Popławska, M, 2017) |
| "CYT-evoked alterations in the protection provided by some antiepileptic drugs against seizures can be of serious concern for epileptic smokers, who might demonstrate therapeutic failure to lacosamide, levetiracetam, and pregabalin, resulting in possible breakthrough seizure attacks." | 3.85 | Cytisine inhibits the protective activity of various classical and novel antiepileptic drugs against 6 Hz-induced psychomotor seizures in mice. ( Florek-Łuszczki, M; Kondrat-Wróbel, MW; Tutka, P; Zaluska, K; Żółkowska, D; Łuszczki, JJ, 2017) |
| " Owing to the major role of neuronal nitric oxide synthase (nNOS) in brain and ineffectiveness of antiepileptic drugs (AEDs) in restoring nitrosative stress, the present study was envisaged to evaluate the adjuvant nNOS inhibitor, 7-nitroindazole (7-NI) with valproic acid for combined treatment of epilepsy and associated depression." | 3.85 | Adjuvant neuronal nitric oxide synthase inhibition for combined treatment of epilepsy and comorbid depression. ( Goel, RK; Singh, T, 2017) |
| " The initial anticonvulsant screening was performed in mice (ip) using the 'classical' maximal electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ) tests as well as in the six-Hertz (6Hz) model of pharmacoresistant limbic seizures." | 3.83 | New hybrid molecules with anticonvulsant and antinociceptive activity derived from 3-methyl- or 3,3-dimethyl-1-[1-oxo-1-(4-phenylpiperazin-1-yl)propan-2-yl]pyrrolidine-2,5-diones. ( Abram, M; Andres-Mach, M; Kamiński, K; Obniska, J; Rapacz, A; Zagaja, M; Łuszczki, JJ, 2016) |
| "Using the mouse maximal electroshock test, the reference model of tonic-clonic seizures, the aim of the present study was to determine the type of interaction between mexiletine (a class IB antiarrhythmic drug) and classical antiepileptics: valproate, carbamazepine, phenytoin, and phenobarbital." | 3.83 | Mexiletine and its Interactions with Classical Antiepileptic Drugs: An Isobolographic Analysis. ( Banach, M; Borowicz-Reutt, KK; Piskorska, B, 2016) |
| "Antiepileptic activity of a new derivative of benzimidazole RU-1205 was studied on the model of pentylenetetrazole-induced generalized seizures in mice." | 3.83 | Antiepileptic Activity of a New Derivative of Benzimidazole RU-1205. ( Anisimova, VA; Grechko, OY; Kalitin, KY; Spasov, AA, 2016) |
| "A 12-year-old boy with intractable epilepsy had tonic and atonic seizures despite treatment with valproic acid (3000mg/day), levetiracetam (3000mg/day) and clobazam (40mg/day)." | 3.83 | Aggravation of atonic seizures by rufinamide: A case report. ( Aydın, A; Aydınlı, N; Bektaş, G; Çalışkan, M; Özmen, M; Pembegül Yıldız, E; Tatlı, B, 2016) |
| " Here, we suggest that triggering limbic seizures with low doses of PTZ in pilocarpine-treated marmosets might provide a more effective basis for the development of AED." | 3.83 | Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment. ( Blanco, MM; Cinini, SM; Lima, TZ; Mello, LE; Pontes, JC; Queiroz, CM, 2016) |
| "The present study aimed to develop a neurochemistry-based single or adjuvant therapy approach for comprehensive management of epilepsy and associated depression employing pentylenetetrazole-kindled animals." | 3.83 | Evidence in support of using a neurochemistry approach to identify therapy for both epilepsy and associated depression. ( Goel, RK; Singh, T, 2016) |
| "Valproic acid (VPA) is a widely used antiepileptic drug with acceptable safety and efficacy in treating pediatric patients with various kinds of seizures." | 3.83 | Effects of UGT1A6 and GABRA1 on Standardized Valproic Acid Plasma Concentrations and Treatment Effect in Children With Epilepsy in China. ( Fang, F; Feng, W; Gao, B; Mei, S; Wu, X; Yang, W; Yu, Y; Zhao, Z; Zhu, L, 2016) |
| " This compound was effective in delaying onset of PTZ-evoked seizures at the dose of 5mg/kg in kindled animals and significantly reduced oxidative stress better than standard drug phenobarbital (PB)." | 3.81 | Design, synthesis and pharmacological evaluation of N-[4-(4-(alkyl/aryl/heteroaryl)-piperazin-1-yl)-phenyl]-carbamic acid ethyl ester derivatives as novel anticonvulsant agents. ( Kumari, S; Mishra, CB; Tiwari, M, 2015) |
| "A patient presented with convulsive seizures when sodium valproate (VPA) and tebipenem pivoxil (Orapenem) were co-administered accidentally." | 3.81 | First case report of suspected onset of convulsive seizures due to co-administration of valproic acid and tebipenem. ( Miki, A; Nakamoto, N; Satoh, H; Sawada, Y; Shihyakugari, A, 2015) |
| "The role of zinc in seizure models and with antiepileptic drugs sodium valproate (SV) and phenytoin (PHT) was studied using experimental models of seizures in rats." | 3.81 | Low dose zinc supplementation beneficially affects seizure development in experimental seizure models in rats. ( Gupta, YK; Katyal, J; Kumar, H, 2015) |
| "We report the case of an aborted awake craniotomy for a left frontotemporoinsular glioma due to ammonia encephalopathy on a patient taking Levetiracetam, valproic acid and clobazam." | 3.81 | Ammonia encephalopathy and awake craniotomy for brain language mapping: cause of failed awake craniotomy. ( Arroyo Pérez, R; Fernández-Candil, JL; León Jorba, A; Pacreu Terradas, S; Villalba Martínez, G; Vivanco-Hidalgo, RM, 2015) |
| " Seizures were controlled in a few weeks with intramuscular synthetic ACTH, followed by valproic acid." | 3.81 | LAMA2-related congenital muscular dystrophy complicated by West syndrome. ( Camacho, A; de Aragón, AM; Dekomien, G; Hernández-Laín, A; Núñez, N; Simón, R, 2015) |
| " We evaluated influence of DHA on anticonvulsant activity of AEDs phenytoin, valproate, and lamotrigine in maximal electroshock (MES), pentylenetetrazole (PTZ), and kindling models of epilepsy." | 3.81 | Synergistic effect of docosahexaenoic acid on anticonvulsant activity of valproic acid and lamotrigine in animal seizure models. ( Babapour, V; Gavzan, H; Sardari, S; Sayyah, M, 2015) |
| " Epileptic rats that developed spontaneous recurrent seizures after a pilocarpine-induced status epilepticus were treated with a KD or control diet (CD)." | 3.81 | Ketogenic diet prevents epileptogenesis and disease progression in adult mice and rats. ( Akula, KK; Boison, D; Coffman, SQ; Lusardi, TA; Masino, SA; Ruskin, DN, 2015) |
| " However, EEG was abnormal and the boy was diagnosed as a case of Landau-Kleffner syndrome (LKS) and treated with sodium valproate, levetiracetam and steroids." | 3.81 | Landau-Kleffner syndrome: an uncommon dealt with case in Southeast Asia. ( Afsar, S; Dixit, NS; Motwani, N; Sharma, N, 2015) |
| "The natural compounds carvacrol and thymol completely prevented seizures in the 6 Hz, 32 mA partial seizure model." | 3.80 | Seizure prevention by the naturally occurring phenols, carvacrol and thymol in a partial seizure-psychomotor model. ( Baker, MT; Mishra, RK, 2014) |
| "Lacosamide (LCM), a new antiepileptic drug (AED) approved as adjunctive therapy for the treatment of patients with partial-onset seizures, has limited pharmacokinetic and drug interaction data." | 3.80 | Lacosamide serum concentrations in adult patients with epilepsy: the influence of gender, age, dose, and concomitant antiepileptic drugs. ( Duncan, JS; Markoula, S; Patsalos, PN; Ratnaraj, N; Sander, JW; Teotonio, R, 2014) |
| "We report the cases of 2 breast cancer patients who received capecitabine(CAP)and concomitant anticonvulsant therapy with either phenytoin(PHT)or valproate(VPA)for brain metastasis." | 3.80 | [Effect of capecitabine therapy on the blood levels of antiepileptic drugs - report of two cases]. ( Ibayashi, Y; Jotoku, H; Takahashi, M; Takasaki, M; Tanaka, H; Watanabe, K, 2014) |
| "Levetiracetam (LEV), used for both partial and generalized seizures, is a frequently preferred antiepileptic because of its few side effects." | 3.80 | Hypokalemia and hypomagnesaemia related to levetiracetam use. ( Aksoy, D; Cevik, B; Kurt, S; Pekdas, E; Solmaz, V, 2014) |
| " Kainic acid (KA) induced seizure, a reliable model of TLE, triggers epileptogenic events resulting from initial neuronal death and ensuing recurring seizures." | 3.80 | Histamine H3 receptor antagonism by ABT-239 attenuates kainic acid induced excitotoxicity in mice. ( Bhowmik, M; Saini, N; Vohora, D, 2014) |
| "A 54-year-old woman with known epilepsy developed convulsions after using rifampicin and flucloxacillin, despite the use of maintenance treatment in the form of carbamazepine, valproic acid and clonazepam." | 3.80 | [Convulsions due to an interaction between anti-epileptic drugs and rifampicin]. ( Hanrath, MA; Swart, EL, 2014) |
| " Initial anticonvulsant screening was performed in mice (ip) using the maximal electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ) seizures tests." | 3.79 | Design, synthesis and anticonvulsant properties of new N-Mannich bases derived from 3-phenylpyrrolidine-2,5-diones. ( Chlebek, I; Kamiński, K; Obniska, J; Rzepka, S; Wiklik, B, 2013) |
| "Valproic acid (VA) is an antiepileptic drug (AED) and histone deacetylase (HDAC) inhibitor taken by patients with glioblastoma (GB) to manage seizures, and it can modulate the biologic effects of radiation therapy (RT)." | 3.79 | Valproic acid use during radiation therapy for glioblastoma associated with improved survival. ( Barker, CA; Beal, K; Bishop, AJ; Chan, TA; Chang, M, 2013) |
| "To examine the efficacy of valproic acid (VPA) given either with or without levetiracetam (LEV) on seizure control and on survival in patients with glioblastoma multiforme (GBM) treated with chemoradiation." | 3.79 | Effect of valproic acid on seizure control and on survival in patients with glioblastoma multiforme. ( Dielemans, JC; Kerkhof, M; Taphoorn, MJ; van Breemen, MS; Vecht, CJ; Walchenbach, R; Zwinkels, H, 2013) |
| "A case of a female patient with juvenile absence epilepsy who developed generalized seizures after the treatment with valproic acid preparations is described." | 3.79 | [A paradoxical reaction on valproates in a female patient with juvenile absence epilepsy]. ( Geĭbatova, LG; Karlov, VA, 2013) |
| "To analyze seizure control, dose adjustments, and other changes of antiepileptic drug (AED) treatment during pregnancy in a large cohort of women with epilepsy entering pregnancy on monotherapy with carbamazepine, lamotrigine, phenobarbital, or valproate." | 3.79 | Seizure control and treatment changes in pregnancy: observations from the EURAP epilepsy pregnancy registry. ( Battino, D; Bonizzoni, E; Craig, J; Lindhout, D; Perucca, E; Sabers, A; Tomson, T; Vajda, F, 2013) |
| "Stiripentol is an effective and well-tolerated therapy that markedly reduced frequency of prolonged seizures in Dravet syndrome." | 3.79 | Stiripentol in Dravet syndrome: results of a retrospective U.S. study. ( Chancharme, L; Chugani, H; de Menezes, MS; Devinsky, O; Franz, DN; Hamiwka, L; Hernandez, A; Laux, L; Le Guern, ME; Mikati, MA; Morse, RP; Saneto, RP; Sullivan, J; Valencia, I; Wirrell, EC, 2013) |
| "The mechanisms by which valproate, one of the most widely prescribed anti-epileptic drugs, suppresses seizures have not been fully elucidated but may involve up-regulation of neuropeptide Y (NPY)." | 3.79 | Long-term valproate treatment increases brain neuropeptide Y expression and decreases seizure expression in a genetic rat model of absence epilepsy. ( Dedeurwaerdere, S; Elms, J; Morris, MJ; O'Brien, TJ; Powell, KL; van Raay, L, 2013) |
| " (MQ) in maximal electroshock (MES) and pentylenetetrazole (PTZ) induced rat models of epilepsy." | 3.79 | Evaluation of anti-epileptic property of Marsilea quadrifolia Linn. in maximal electroshock and pentylenetetrazole-induced rat models of epilepsy. ( Avinash, H; Chandrashekar, BR; Mukunda, N; Naduvil Narayanan, S; Nayak, BS; Raghavendra Rao, K; Sadhana, N; Satish Kumar, MC; Snehunsu, A; Vijay Kapgal, K, 2013) |
| " Using the prenatal valproic acid (VPA)-injection model of autism spectrum disorder (ASD) in rats, which produces social impairrment and altered seizure susceptibility as in human ASD patients as well as mild neural tube defects like crooked tail phenotype, we examined whether chronic administration of red ginseng extract may rescue the social impairment and crooked tail phenotype in prenatally VPA-exposed rat offspring." | 3.79 | Effects of Korean red ginseng extracts on neural tube defects and impairment of social interaction induced by prenatal exposure to valproic acid. ( Han, SH; Kim, HJ; Kim, HY; Kim, KC; Kim, P; Kwon, KJ; Lee, JM; Park, JH; Shin, CY, 2013) |
| " Our data have demonstrated that pentylenetetrazole (PTZ)-induced seizures did not alter ATP, ADP, and AMP hydrolysis in brain membrane fractions." | 3.79 | Antiepileptic drugs prevent changes in adenosine deamination during acute seizure episodes in adult zebrafish. ( Bogo, MR; Bonan, CD; Nery, LR; Piato, AL; Schaefer, IC; Siebel, AM, 2013) |
| "A novel class of 19 carbamates was synthesized, and their anticonvulsant activity was comparatively evaluated in the rat maximal electroshock (MES) and subcutaneous metrazol (scMet) seizure tests and pilocarpine-induced status epilepticus (SE) model." | 3.78 | Syntheses and evaluation of anticonvulsant activity of novel branched alkyl carbamates. ( Bialer, M; Hen, N; Yagen, B, 2012) |
| "A new series of 2,3,8-trisubstituted-4(3H)-quinazoline derivatives were synthesized, evaluated for their anticonvulsant activity against electrically (MES) and chemically (PTZ, picrotoxin and Strychnine) induced seizures and compared with the standard drugs methaqualone and sodium valproate." | 3.78 | Synthesis and anticonvulsant evaluation of some new 2,3,8-trisubstituted-4(3H)-quinazoline derivatives. ( El-Azab, AS; Eltahir, KE, 2012) |
| " calamus (HAEAC) on conventional antiepileptic drugs (AEDs), sodium valproate and carbamazepine was determined using pentylenetetrazole-induced seizures model in rats." | 3.78 | Interaction of hydroalcoholic extract of Acorus calamus Linn. with sodium valproate and carbamazepine. ( Gupta, YK; Katyal, J; Sarangal, V, 2012) |
| " Previous work demonstrated the convulsive and widespread neuropathological effects of soman, an organophosphorus compound that causes SE and severe recurrent seizures as a result of exposure." | 3.78 | Combined diazepam and HDAC inhibitor treatment protects against seizures and neuronal damage caused by soman exposure. ( Addis, M; Bailey, K; Chanda, S; de Araujo Furtado, M; Lumley, LA; Moffett, M; Pak, T; Robertson, BD; Rossetti, F; Shields, M; Yourick, DL, 2012) |
| "Many investigators agree that appropriate rational utilization of therapeutic drug monitoring (TDM) with Bayesian feedback dosage adjustment facilitates epilepsy treatment with carbamazepine (CBZ) and/or valproate (VPA) by increasing the seizure control and safety, as well as by reducing treatment costs." | 3.77 | Predictability of individualized dosage regimens of carbamazepine and valproate mono- and combination therapy. ( Andreeva, OV; Bondareva, IB; Bondareva, KI; Jelliffe, RW, 2011) |
| "The anticonvulsant activity of BmK AS, a sodium channel site 4-selective modulator purified from scorpion venom (Buthus martensi Karsch), was investigated in unanesthetized rats with acute pentylenetetrazole (PTZ)- and pilocarpine-induced seizures." | 3.77 | Anticonvulsant activity of BmK AS, a sodium channel site 4-specific modulator. ( Chen, L; Feng, Q; Ji, YH; Wang, Y; Weng, CC; Zhang, XY; Zhao, R; Zhu, HY, 2011) |
| "The patient's hypoalbuminemia probably explains the remarkably high free fraction of valproic acid." | 3.77 | High unbound fraction of valproic acid in a hypoalbuminemic critically ill patient on renal replacement therapy. ( de Maat, MM; Edelbroek, PM; van Leeuwen, HJ, 2011) |
| " The aim of our study was to analyze the effect of age, gender, daily RUF dose per body weight (mg/kg), valproic acid (VPA), and enzyme-inducing antiepileptic drugs (EIAEDs) on RUF concentration-to-dose ratio (RUF serum concentration/RUF dose per body weight), RUF clearance (RUF dose/RUF serum concentration), and RUF trough concentrations." | 3.77 | Serum concentrations of rufinamide in children and adults with epilepsy: the influence of dose, age, and comedication. ( Boor, R; Brandt, C; Jürgens, U; Korn-Merker, E; May, TW; Rambeck, B, 2011) |
| "This prospective study was designed to investigate whether or not monotherapy with sodium valproate (VPA) or oxcarbazepine (OXC) affects plasma levels of fatty acylcarnitine esters in children with epilepsy." | 3.77 | Analysis of acylcarnitine levels by tandem mass spectrometry in epileptic children receiving valproate and oxcarbazepine. ( Biberoglu, G; Cansu, A; Ezgu, FS; Hasanoglu, A; Hirfanoglu, TL; Serdaroglu, A; Tumer, L, 2011) |
| "Lacosamide ((R)-N-benzyl 2-acetamido-3-methoxypropionamide, (R)-1) is a low molecular weight anticonvulsant recently introduced in the United States and Europe for adjuvant treatment of partial-onset seizures in adults." | 3.76 | The structure-activity relationship of the 3-oxy site in the anticonvulsant (R)-N-benzyl 2-acetamido-3-methoxypropionamide. ( Kohn, H; Morieux, P; Park, KD; Salomé, C; Stables, JP, 2010) |
| " Antiepileptics (carbamazepine, sodium valproate, zonisamide, clobazam, and topiramate), which are used for complex partial epilepsy or secondary generalized epilepsy in clinical practice, were orally administrated to kindled rats." | 3.76 | The usefulness of olfactory bulb kindling as a model for evaluation of antiepileptics. ( Akagi, M; Fujiwara, A; Ishikawa, T; Kaida, Y; Kamei, C; Takechi, K; Watanabe, Y, 2010) |
| " MET test (PTZ at the dose of 70 mg/kg) acute seizures in Wistar rats, in comparison to valproic acid (VPA)." | 3.76 | Levetiracetam in submaximal subcutaneous pentylentetrazol-induced seizures in rats. ( Arcieri, S; Coppola, G; D'Aniello, A; Messana, T; Pascotto, A; Signoriello, G; Verrotti, A, 2010) |
| " The aim of the current study was to evaluate the effects of losartan (2-n-butyl-4-chloro-5-hydroxymethyl-1-[(2'(1H-tetrazol-5-yl)-biphenil-4-yl)methyl]imidazole) and telmisartan (49-[(1,49-dimethyl-29-propyl[2,69-bi-1H-benzimidazo]-19-yl)methyl]-[1,19-biphenyl]-2-carboxylic acid), the angiotensin AT1 receptor antagonists which are widely used in clinical practice, on the protective action of conventional antiepileptic drugs (carbamazepine, phenytoin, valproate and phenobarbital) against maximal electroshock-induced seizures in mice." | 3.76 | Angiotensin AT1 receptor antagonists enhance the anticonvulsant action of valproate in the mouse model of maximal electroshock. ( Czuczwar, SJ; Jakubus, T; Janowska, A; Tochman-Gawda, A; Łukawski, K, 2010) |
| " The anticonvulsant activity of all of the synthesized compounds was evaluated against maximal electrical shock (MES) and subcutaneous pentylenetetrazole (scPTZ) induced seizures." | 3.76 | Synthesis and anticonvulsant activity of 4-oxo and 4-thioxo-8-bromobenzopyran derivatives. ( Abd El-Latif, HA; Abu Yossef, HA; Hassan, GS; Ragab, FA; Yahya, TA, 2010) |
| "For the acute study, in the maximal electroshock seizure model, the administration of 1 mg/kg of amlodipine resulted in the complete abolition of seizures in 33 percent of the mice, and this was increased to 67 percent with the administration of 4 mg/kg." | 3.76 | An experimental study of the anticonvulsant effect of amlodipine in mice. ( Sathyanarayana Rao, KN; Subbalakshmi, NK, 2010) |
| "Pioglitazone, a peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonist, is used in inflammatory brain diseases, and it was shown to protect against seizures in genetically epileptic mice." | 3.76 | Anticonvulsant potential of the peroxisome proliferator-activated receptor γ agonist pioglitazone in pentylenetetrazole-induced acute seizures and kindling in mice. ( Abdallah, DM, 2010) |
| " Her serum valproic acid concentration was <1 mg/L, but seizures did not recur." | 3.76 | Decrease in serum valproic acid levels during treatment with ertapenem. ( Chen, CY; Huang, YB; Liao, FF, 2010) |
| " A number of VPA analogues and their amide, N-methylamide and urea derivatives, were synthesized and evaluated in animal models of neuropathic pain and epilepsy." | 3.75 | Synthesis and evaluation of antiallodynic and anticonvulsant activity of novel amide and urea derivatives of valproic acid analogues. ( Bialer, M; Devor, M; Kaufmann, D; Shimshoni, JA; Yagen, B, 2009) |
| "This report describes an 85-year-old Chinese male inpatient who twice received concomitant administration of meropenem and valproic acid for the treatment of pneumonia and poststroke epilepsy, respectively." | 3.75 | Effect of concomitant administration of meropenem and valproic acid in an elderly Chinese patient. ( Gu, J; Huang, Y, 2009) |
| "We describe an 11-year-old girl with a seizure disorder who developed fever, rash, rhabdomyolysis, and multiorgan failure 2 weeks after commencing a transition from sodium valproate to lamotrigine therapy." | 3.75 | Life-threatening organ failure after lamotrigine therapy. ( Dargan, PI; Ferguson, LP; Hood, JL; Tibby, SM, 2009) |
| "This study was designed so as to characterize the interactions between levetiracetam (LEV) and the conventional antiepileptic drugs (AEDs) clonazepam (CZP), ethosuximide (ETS), phenobarbital (PB), and valproate (VPA) in suppressing pentylenetetrazole (PTZ)-induced clonic seizures in mice by use of type II isobolographic analysis." | 3.75 | Isobolographic characterization of the anticonvulsant interaction profiles of levetiracetam in combination with clonazepam, ethosuximide, phenobarbital and valproate in the mouse pentylenetetrazole-induced seizure model. ( Andres-Mach, MM; Czuczwar, SJ; Dudra-Jastrzebska, M; Luszczki, JJ; Patsalos, PN; Ratnaraj, N, 2009) |
| "In a single-center pilot study, the size of the HIV reservoir of 11 patients receiving valproic acid for seizures for more than 2 years was compared with 13 matched patients." | 3.74 | Prolonged valproic acid treatment does not reduce the size of latent HIV reservoir. ( Aboulker, JP; Boufassa, F; Chaix, ML; Costagliola, D; Delfraissy, JF; Goujard, C; Lambotte, O; Lamine, A; Paller, C; Pallier, C; Sagot-Lerolle, N, 2008) |
| " By contrast, offspring of rats exposed to carbamazepine (which at the dose used produced low plasma concentrations) or to generalized convulsive seizures showed no clear-cut evidence of dysplasias." | 3.74 | Fetal exposure to GABA-acting antiepileptic drugs generates hippocampal and cortical dysplasias. ( Ben-Ari, Y; Depaulis, A; Jorquera, I; Manent, JB; Mazzucchelli, I; Perucca, E; Represa, A, 2007) |
| " We studied the potential anticonvulsant effect of thalidomide: Different doses of thalidomide were tested against seizures induced by 50 mg/kg or 70 mg/kg of pentylenetetrazole (PTZ); the anticonvulsant effect of thalidomide was also compared with that of valproic acid." | 3.74 | Thalidomide inhibits pentylenetetrazole-induced seizures. ( Calderon, A; Palencia, G; Sotelo, J, 2007) |
| " In the present study, we compared the effects of riluzole and valproate (VPA) in the pilocarpine-induced limbic seizure model and in the gamma-hydroxybutyrate lactone (GBL)-induced absence seizure model." | 3.74 | Anti-glutamatergic effect of riluzole: comparison with valproic acid. ( Choi, HC; Choi, SY; Kang, TC; Kim, DS; Kim, JE; Kim, YI; Kwak, SE; Kwon, OS; Song, HK, 2007) |
| "Using the mouse maximal electroshock-induced seizure model, indicative of tonic-clonic seizures in humans, the present study was aimed at characterizing the interaction between remacemide and valproate, carbamazepine, phenytoin, and phenobarbital." | 3.74 | Isobolographic analysis of interactions between remacemide and conventional antiepileptic drugs in the mouse model of maximal electroshock. ( Borowicz, KK; Czuczwar, SJ; Luszczki, JJ; Malek, R; Patsalos, PN; Ratnaraj, N, 2007) |
| " The anticonvulsant activity of F1,6BP was determined in rat models of acute seizures induced by pilocarpine, kainic acid, or pentylenetetrazole." | 3.74 | Fructose-1,6-bisphosphate has anticonvulsant activity in models of acute seizures in adult rats. ( Khan, FA; Lian, XY; Stringer, JL, 2007) |
| "Oral rufinamide suppressed pentylenetetrazol-induced seizures in mice (ED(50) 45." | 3.74 | The anticonvulsant profile of rufinamide (CGP 33101) in rodent seizure models. ( Franklin, MR; Kupferberg, HJ; Schmutz, M; Stables, JP; White, HS; Wolf, HH, 2008) |
| "Therapeutic efficacy of valparin xr, a new form of valproic acid (VPA) generic drugs, manufactured by "Torrent Pharmaceuticals Ltd", India, has been studied in 25 patients with epilepsy of different types and frequency of seizures." | 3.74 | [The use of generic valparin xr in the treatment of epilepsy.]. ( Gromov, SA; Lipatova, LV, 2007) |
| " The combination of AGLD (5 mg/kg) with phenobarbital (PB, applied at its subeffective dose of 15 mg/kg) significantly shortened motor seizure and afterdischarge duration in amygdala-kindled seizures." | 3.73 | Aminoglutethimide but not spironolactone enhances the anticonvulsant effect of some antiepileptics against amygdala-kindled seizures in rats. ( Borowicz, KK; Czuczwar, SJ, 2005) |
| " Lower doses of valproate and carbamazepine were required to prevent hyperactivity compared to doses required to block tonic-clonic seizures induced by pentylenetetrazole." | 3.73 | Evaluation of the effects of lamotrigine, valproate and carbamazepine in a rodent model of mania. ( Arban, R; Brackenborough, K; Gerrard, P; Large, C; Maraia, G; Wilson, A; Winyard, L, 2005) |
| "To report a probable interaction between meropenem and valproic acid that resulted in the development of epileptic seizures." | 3.73 | Acute seizures due to a probable interaction between valproic acid and meropenem. ( Borrás-Blasco, J; Coves-Orts, FJ; Murcia-López, A; Navarro-Ruiz, A; Palacios-Ortega, F, 2005) |
| " He had been obese, had been receiving a standard dose of valproic acid since clipping surgery for subarachnoid hemorrhage 17 years previously, and had not consumed any alcohol since the surgery." | 3.73 | Hepatocellular carcinoma and nonalcoholic steatohepatitis developing during long-term administration of valproic acid. ( Iizuka, H; Katsuda, S; Okamoto, K; Sato, K; Ueda, Y; Ueno, K, 2005) |
| "Isobolographic analysis was used to characterize the interactions between loreclezole (LCZ) and clonazepam (CZP), ethosuximide (ETS), phenobarbital (PB), and valproate (VPA) in suppressing pentylenetetrazole (PTZ)-induced seizures and in producing acute neurotoxic adverse effects in the chimney test in mice so as to identify optimum combinations." | 3.73 | Pharmacodynamic and/or pharmacokinetic characteristics of interactions between loreclezole and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice: an isobolographic analysis. ( Czuczwar, SJ; Luszczki, JJ; Patsalos, PN; Ratnaraj, N, 2005) |
| "We report on a 4-year 8-month-old boy with Panayiotopoulos syndrome who showed atypical evolution with newly developed absence seizures and EEG exacerbation induced by carbamazepine." | 3.73 | EEG and seizure exacerbation induced by carbamazepine in Panayiotopoulos syndrome. ( Akiyama, T; Endoh, F; Ito, M; Kikumoto, K; Ohtsuka, Y; Oka, M; Yoshinaga, H, 2006) |
| "In the present study, the mechanism behind flurothyl-induced seizures was examined using drugs acting on the GABA-benzodiazepine receptor complex in Mongolian gerbils." | 3.73 | Effects of drugs acting on the GABA-benzodiazepine receptor complex on flurothyl-induced seizures in Mongolian gerbils. ( Araki, H; Gomita, Y; Hashimoto, Y; Suemaru, K, 2006) |
| " Pentylenetetrazole (PTZ)-induced seizures were used to evaluate the anticonvulsant effect of drugs." | 3.73 | Modulation of pentylenetetrazole-induced seizures and oxidative stress parameters by sodium valproate in the absence and presence of N-acetylcysteine. ( Pillai, KK; Uma Devi, P; Vohora, D, 2006) |
| "Sixty critically ill pediatric patients receiving phenytoin for treatment of seizures in a large multidisciplinary intensive care unit." | 3.73 | Total phenytoin concentrations do not accurately predict free phenytoin concentrations in critically ill children. ( Dodson, B; McClain, CD; McManus, ML; Wolf, GK; Zurakowski, D, 2006) |
| "Isobolographic analysis was used to characterize the interactions between stiripentol (STP) and clonazepam (CZP), ethosuximide (ETS), phenobarbital (PB), and valproate (VPA) in suppressing pentylenetetrazole (PTZ)-induced clonic seizures in mice." | 3.73 | Characterization of the anticonvulsant, behavioral and pharmacokinetic interaction profiles of stiripentol in combination with clonazepam, ethosuximide, phenobarbital, and valproate using isobolographic analysis. ( Czuczwar, SJ; Luszczki, JJ; Patsalos, PN; Ratnaraj, N, 2006) |
| " Anticonvulsant effects were evaluated against seizures induced by 14 mg kg(-1) of 4-aminopyridine (4-AP) and by 110 mg kg(-1) of pentylenetetrazole (PTZ), and neurotoxicity by the rotarod test." | 3.72 | Is the interaction between felbamate and valproate against seizures induced by 4-aminopyridine and pentylenetetrazole in mice beneficial? ( Amat, G; Armijo, JA; Cuadrado, A, 2003) |
| " The aim of this study was to evaluate the profile of interactions between FBM and four conventional antiepileptic drugs (AEDs): clonazepam (CZP), ethosuximide (ESM), phenobarbital (PB), and valproate (VPA), in pentylenetetrazole (PTZ)-induced convulsions in mice, a model of myoclonic seizures in humans." | 3.72 | Isobolographic and subthreshold analysis of interactions among felbamate and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice. ( Borowicz, KK; Czuczwar, SJ; Luszczki, JJ, 2004) |
| " Alphaxalone (up to 5 mg/kg) did not exert a significant action against amygdala-kindled seizures in rats, or against pentetrazole- or aminophylline-induced convulsions in mice." | 3.71 | Interaction of the neurosteroid alphaxalone with conventional antiepileptic drugs in different types of experimental seizures. ( Borowicz, KK; Czuczwar, SJ; Kleinrok, Z; Kowalska, A; Swiader, M; Zadrozniak, M, 2002) |
| " Anticonvulsant effects were evaluated against seizures induced by both 4-aminopyridine and pentylenetetrazole, and neurotoxic effects were evaluated by the rotarod test." | 3.71 | Synergistic interaction between valproate and lamotrigine against seizures induced by 4-aminopyridine and pentylenetetrazole in mice. ( Armijo, JA; Cuadrado, A; de las Cuevas, I; Valdizán, EM, 2002) |
| "We present a patient with early infantile epileptic encephalopathy with suppression bursts (Ohtahara syndrome) with an excellent response to chloral hydrate to draw attention to a possible role of the "old" drug in the treatment of intractable epilepsy." | 3.71 | Successful treatment of Ohtahara syndrome with chloral hydrate. ( Komárek, V; Krsek, P; Maulisová, A; Procházka, T; Sebronová, V, 2002) |
| "A 14-year-old child treated with valproic acid over several years for a seizure disorder developed abdominal pain with radiological evidence of acute pancreatitis." | 3.71 | A case of chronic pancreatic insufficiency due to valproic acid in a child. ( Cooper, MA; Groll, A, 2001) |
| " Seizures were induced by timed infusion of pentylenetetrazole (PTZ) and maximal electroshock (MES)." | 3.71 | Comparison of the anticonvulsant efficacies and neurotoxic effects of valproic acid, phenytoin, and the ketogenic diet. ( Bough, KJ; Eagles, DA, 2001) |
| "Molsidomine (25 mg kg(-1)), a donor of nitric oxide, commonly used in the treatment of coronary artery disease, enhanced the protective activity of valproate against the clonic phase of pentylenetetrazole-induced seizures in mice, significantly reducing the ED(50) of valproate from 123." | 3.71 | Molsidomine enhances the protective activity of valproate against pentylenetetrazole-induced seizures in mice. ( Arent, K; Kleinrok, Z; Tutka, P; Wielosz, M; Łuszczki, J, 2002) |
| "The authors herein present two children with mild absence epilepsy, having intermittent absences, who developed absence status evolving into atonic generalized seizures and drop attacks along with progressive disorientation induced by relatively small doses of valproic acid." | 3.71 | Valproic acid therapy inducing absence status evolving into generalized seizures. ( Andraus, J; Sagie-Lerman, T; Savitzki, D; Shahar, E, 2002) |
| "Effect of nimodipine was studied alone and in combination with phenytoin and valproate in maximal electroshock seizures in rats." | 3.70 | Effect of nimodipine on the efficacy of commonly used antiepileptic drugs in rats. ( Balakrishnan, S; Bhargava, VK; Pandhi, P, 1998) |
| "The efficacy of Flunarizine (FLU), a calcium channel blocker, in combination with conventional antiepileptic drugs, phenytoin (PHT), carbamazepine (CBZ), sodium valproate (VPA), and ethosuximide (ESM), at ED50 doses, were examined for protective effects against maximal electroshock seizures (MES) and pentylenetetrazol (PTZ) induced seizures in mice." | 3.70 | Additive anticonvulsant effect of flunarizine and sodium valproate on electroshock and chemoshock induced seizures in mice. ( David, J; Joseph, S; Joseph, T, 1998) |
| "We describe two patients who developed levodopa-responsive parkinsonism without dementia at least 4 years after beginning chronic valproate (VPA) treatment for seizures." | 3.70 | Reversible parkinsonism induced by prolonged treatment with valproate. ( Onofrj, M; Paci, C; Thomas, A, 1998) |
| "N(G)-nitro-L-arginine (NNA; an inhibitor of nitric oxide synthase) in a dose of 40 mg/kg impaired the protective activity of ethosuximide against the clonic phase of pentylenetetrazol-induced seizures in mice." | 3.70 | N(G)-nitro-L-arginine impairs the anticonvulsive action of ethosuximide against pentylenetetrazol. ( Czuczwar, SJ; Kleinrok, Z; Klonowski, P; Tutka, P, 1999) |
| " The effects of systemic pretreatment with hydrocortisone (5-25 mg/kg), pyridoxine (20-250 mg/kg), and sodium valproate (VPA; 200 and 400 mg/kg) against the NMDA-induced automatisms, emprosthotonic (hyperflexion), and clonic-tonic seizures were determined." | 3.70 | Age-specific N-methyl-D-aspartate-induced seizures: perspectives for the West syndrome model. ( Kábová, R; Liptáková, S; Pometlová, M; Slamberová, R; Velísek, L, 1999) |
| "The activity of nimodipine and nitrendipine against pentylenetetrazole (PTZ) induced seizures in Albino rats was studied alone and in combination with valproate." | 3.70 | Anticonvulsant profile of nimodipine and nitrendipine against pentylenetetrazole induced seizures in rats. ( Balakrishnan, S; Bhargava, VK; Pandhi, P, 1999) |
| " In the present study, it was evaluated whether circannual rhythms affect the anticonvulsant activity of phenobarbital, carbamazepine, or valproate in two mouse models of generalized seizures, i." | 3.70 | The role of technical, biological, and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. VII. Seasonal influences on anticonvulsant drug actions in mouse models of generalized seizures. ( Fiedler, M; Löscher, W, 2000) |
| "The effects of GABAmimetic drugs on inhibition of amygdaloid kindled seizures induced by clobenpropit were investigated to clarify the relationship between histaminergic and GABAergic systems in seizures." | 3.70 | Participation of GABAergic and histaminergic systems in inhibiting amygdaloid kindled seizures. ( Chen, Z; Fujii, Y; Ishizawa, K; Kamei, C; Okuma, C; Sugimoto, Y, 2000) |
| "Perimenstrual catamenial epilepsy, the exacerbation of seizures in association with menstruation, may in part be due to withdrawal of the progesterone metabolite allopregnanolone (3alpha-hydroxy-5alpha-pregnan-20-one), an endogenous anticonvulsant neurosteroid that is a positive allosteric modulator of gamma-aminobutyric acid(A) receptors." | 3.70 | Enhanced anticonvulsant activity of ganaxolone after neurosteroid withdrawal in a rat model of catamenial epilepsy. ( Reddy, DS; Rogawski, MA, 2000) |
| "We report a case of stroke in a child with acquired protein C deficiency receiving valproic acid (VPA)." | 3.70 | Protein C deficiency related to valproic acid therapy: a possible association with childhood stroke. ( Balasa, V; Degrauw, A; Fogelson, H; Gartside, P; Glauser, T; Gruppo, R, 2000) |
| "Selected examples from three series of isomeric (alkylthio)-1,2,4-triazoles were prepared and examined for anticonvulsant activity versus strychnine-, maximal-electroshock-, pentylenetetrazole-, and 3-mercaptopropionic-acid-induced seizures in mice." | 3.69 | 5-Aryl-3-(alkylthio)-4H-1,2,4-triazoles as selective antagonists of strychnine-induced convulsions and potential antispastic agents. ( Dalton, CR; Dudley, MW; Kane, JM; Kehne, JH; Ketteler, HJ; McCloskey, TC; Miller, FP; Ogden, AM; Senyah, Y; Staeger, MA, 1994) |
| " This compound blocked bicuculline induced seizures, did not elevate seizure threshold following iv infusion of metrazole, and blocked influx of Ca2+ ions into cerebellar granule cells induced by K+ or veratridine." | 3.69 | Aroyl(aminoacyl)pyrroles, a new class of anticonvulsant agents. ( Almond, HR; Carmosin, RJ; Carson, JR; Pitis, PM; Stables, JP; Swinyard, EA; Vaught, JL; White, HS; Wolf, HH, 1997) |
| "The authors report a case of fatal hepatic failure in a 19-year old young man suffering from absence seizures and treated for two months with valproic acid (VPA)." | 3.69 | [Fatal hepatic necrosis during treatment with sodium valproate]. ( Benaguida, M; Chlihi, A; Miguil, M; Mjahed, K; Moutawakkil, S; Sarf, I, 1995) |
| "Valproic acid and ethosuximide are commonly used to treat absence seizures, but their mechanisms of action have not been clearly defined." | 3.69 | Valproic acid and ethosuximide slow the onset of maximal dentate activation in the rat hippocampus. ( Stringer, JL, 1994) |
| "The charts of 55 patients receiving clozapine and valproate concurrently between May 8, 1989, and May 8, 1992, were reviewed to determine the indication for and length of time on each medication, abnormalities in liver function test results, blood cell dyscrasias, seizures, nausea, vomiting, sedation, sialorrhea, and enuresis." | 3.69 | Concurrent use of clozapine and valproate in affective and psychotic disorders. ( Castillo, J; Centorrino, F; Kando, JC; Tohen, M, 1994) |
| "An 11-year-old girl with juvenile neuronal ceroid lipofuscinosis developed acute pancreatitis secondary to valproic acid treatment, which resolved after discontinuation of the medication and conservative treatment." | 3.69 | Valproate-associated acute pancreatitis in a child with neuronal ceroid lipofuscinosis. ( Talwar, D, 1994) |
| " To test the effect of antiepileptic drugs on kindled seizures and kindling-induced learning deficits we injected ethosuximide, dipropylacetate, and phenobarbital prior to each kindling stimulation or after kindling completion, and tested these animals in a shuttle-box paradigm." | 3.69 | Antiepileptic drugs--their effects on kindled seizures and kindling-induced learning impairments. ( Becker, A; Brosz, M; Grecksch, G, 1995) |
| "We evaluated the protective activity (expressed as ED50 values in mg/kg of phenobarbital (PB, 120 min before testing) and valproate (30 min) alone or combined with caffeine in male mice with seizures induced by maximal electroshock (MES)." | 3.69 | Anticonvulsant activity of phenobarbital and valproate against maximal electroshock in mice during chronic treatment with caffeine and caffeine discontinuation. ( Borowicz, K; Buszewicz, G; Czuczwar, SJ; Gasior, M; Kleinrok, Z, 1996) |
| "Aminophylline reversed the protective action of both, D-3-(2-carboxypiperazine-4-yl)-1-propenyl-1-phosphonic acid (D-CPP-ene-a competitive NMDA antagonist) and valproate (used as a conventional antiepileptic drug for comparative purposes) against maximal electroshock-induced seizures." | 3.69 | Influence of aminophylline and strychnine on the protective activity of excitatory amino acid antagonists against maximal electroshock-induced convulsions in mice. ( Czuczwar, SJ; Kleinrok, Z; Turski, WA; Tutka, P, 1996) |
| "Among three calcium channel inhibitors, only nicardipine (10-40 mg/kg) significantly inhibited clonic seizures induced by pentylenetetrazol administered at its CD97 (convulsive dose 97%) of 81 mg/kg, subcutaneously." | 3.69 | Influence of nicardipine, nimodipine and flunarizine on the anticonvulsant efficacy of antiepileptics against pentylenetetrazol in mice. ( Brudniak, T; Czuczwar, SJ; Gasior, M; Kamiński, R; Kleinrok, Z, 1996) |
| "An epileptic patient well controlled on valproic acid (VPA) developed a prolonged episode of status epilepticus 12 days after initiation of 75 mg of clomipramine (CMI) to treat depression." | 3.69 | Status epilepticus associated with the combination of valproic acid and clomipramine. ( DeToledo, JC; Haddad, H; Ramsay, RE, 1997) |
| "The relative ability of derivatives of 2-piperidinecarboxylic acid (2-PC; pipecolic acid) and 3-piperidinecarboxylic acid (3-PC; nipecotic acid) to block maximal electroshock (MES)-induced seizures, elevate the threshold for electroshock-induced seizures and be neurotoxic in mice was investigated." | 3.69 | Anticonvulsant activity of novel derivatives of 2- and 3-piperidinecarboxylic acid in mice and rats. ( Andersen, PH; Burns, CM; Chang, H; Crider, AM; el-Assadi, AA; Hinko, CN; Ho, B; Kliem, MA; Klitgaard, H; Seo, TH; Steinmiller, CL; Tietz, EI; Venkatarangan, P, 1996) |
| "We report the effects of two new dihydropyridine derivatives, isradipine (4-(4'-benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedic arboxylic acid methylisopropylester) and niguldipine (1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinecarboxylic acid 3-(4,4-diphenyl-1-piperidinyl)-propyl methyl ester hydrochloride), and of dantrolene (1-[(5-[p-nitrophenyl]furfurylidene)-amino]hydantoin sodium, an inhibitor of Ca2+ release from intracellular stores) on the protective efficacy of antiepileptic drugs against maximal electroshock-induced seizures." | 3.69 | Influence of isradipine, niguldipine and dantrolene on the anticonvulsive action of conventional antiepileptics in mice. ( Borowicz, KK; Czuczwar, SJ; Gasior, M; Kleinrok, Z, 1997) |
| "The effects of valproate on CNS concentrations of gamma-aminobutyric acid (GABA), glulamate (GLU), glutamine (GLN); dopamine (DA), serotonin (5-HT), and metabolites were examined in tissue extracts of caudate nucleus of genetic substrains of Balb/c mice susceptible (EP) or resistant (ER) to audiogenic seizures." | 3.69 | Effects of valproate on amino acid and monoamine concentrations in striatum of audiogenic seizure-prone Balb/c mice. ( Alexiuk, NA; Vriend, JP, 1996) |
| " The interaction of theophylline and the antiepileptic drugs diazepam and sodium valproate was studied in pentylenetetrazole (PTZ) - kindled seizures in rats." | 3.69 | Effect of theophylline on diazepam and sodium valproate protection in pentylenetetrazole - kindled seizures in rats. ( Gupta, YK; Malhotra, J, 1997) |
| "We report on a 33-year-old female suffering from frequent complex-partial seizures who developed a non-convulsive status epilepticus after one week of antiepileptic therapy with valproate (VPA) which had been added to a basic medication with barbexaclone (BBC) in rapidly increasing dosage." | 3.68 | Temporary abolition of seizure activity by flumazenil in a case of valproate-induced non-convulsive status epilepticus. ( Steinhoff, BJ; Stodieck, SR, 1993) |
| "2 s)-induced tonic seizures and lethality but failed to protect from aminophylline (150 mg/kg i." | 3.68 | Search for an antidote to electroconvulsion and lethality in aminophylline-sensitized mice. ( Chakrabarti, A; Chugh, Y; Sharma, PL, 1993) |
| ") potentiated the anticonvulsant properties of phenytoin, phenobarbital and valproate against audiogenic seizures in DBA/2 mice." | 3.68 | Effects of some calcium antagonists upon the activity of common antiepileptic compounds on sound-induced seizures in DBA/2 mice. ( De Sarro, A; De Sarro, GB; Nistico', G; Trimarchi, GR, 1992) |
| "Immature rats are more susceptible to clonic seizures induced by aminooxyacetic acid (AOAA) than mature and senile rats." | 3.68 | Age dependency of the susceptibility of rats to aminooxyacetic acid seizures. ( Cavalheiro, EA; Dziki, M; Kleinrok, Z; Parada, J; Turski, W, 1992) |
| "We studied the distribution of valproic acid (VPA) between brain (gray matter) and serum in 13 patients receiving chronic VPA therapy who underwent cortical resections for intractable seizures." | 3.68 | Low and variable presence of valproic acid in human brain. ( Dills, RL; Friel, PN; Levy, RH; Ojemann, GA; Rapport, RL; Shen, DD, 1992) |
| ") prevented tonic, but not clonic, seizures induced by bicuculline in mice." | 3.68 | Anticonvulsant activity of the imidazoline 6,7-benzoidazoxan. ( Dickinson, SL; Jackson, HC; Nutt, DJ; Ripley, TL, 1991) |
| " Seizures were uninfluenced by treatment with carbamazepine." | 3.68 | Myoclonic epilepsy--pitfalls in diagnosis and management. ( Brodie, MJ; Larkin, JG; McGinn, G; McKee, PJ, 1991) |
| "05 mg/kg) offered no protection against electroconvulsions in mice but potentiated the anticonvulsant action of diazepam and valproate against maximal electroshock-induced seizures, decreasing the respective ED50 values from 9." | 3.68 | Differential effects of agents enhancing purinergic transmission upon the antielectroshock efficacy of carbamazepine, diphenylhydantoin, diazepam, phenobarbital, and valproate in mice. ( Czuczwar, SJ; Janusz, W; Kleinrok, Z; Szczepanik, B; Wamil, A, 1990) |
| "A 5-year-old child receiving valproic acid syrup for seizure control developed diarrhea probably from the excipient ingredients." | 3.68 | Excipients in valproic acid syrup may cause diarrhea: a case report. ( Veerman, MW, 1990) |
| " The compounds were tested in mice against seizures induced by maximal electroshock (MES) and pentylenetetrazole and in the rotorod assay for neurologic deficit." | 3.67 | Anticonvulsant activity of 2- and 3-aminobenzanilides. ( Clark, CR; Lin, CM; Sansom, RT, 1986) |
| " The compounds were tested in mice against seizures induced by electroshock and metrazole (pentylenetetrazole) and in the rotorod assay for neurologic deficit." | 3.67 | Anticonvulsant activity of some 4-aminobenzanilides. ( Clark, CR; Lin, CM; Norris, GN; Sansom, RT, 1985) |
| "The anticonvulsant potency of 2-propyl-2-pentenoic acid (2-en-VPA; trans isomer), a major metabolite of the antiepileptic valproic acid (VPA), was evaluated in different animal models of epilepsy and compared with the respective data for VPA." | 3.67 | Comparative evaluation of anticonvulsant and toxic potencies of valproic acid and 2-en-valproic acid in different animal models of epilepsy. ( Löscher, W; Marescaux, C; Nau, H; Vergnes, M, 1984) |
| "A detailed case history of lead poisoning in a young infant is presented." | 3.67 | Lead-induced convulsions in young infants--a case history and the role of GABA and sodium valproate in the pathogenesis and treatment. ( Aslam, M; Fernando, NP; Harrison, PG; Healy, MA, 1984) |
| "The anticonvulsant effect of either phenobarbital or dilantin was potentiated by exogenous glycine in DBA/2 audiogenic seizure mice and in 3-mercaptopropionic acid-induced seizures." | 3.67 | Glycine potentiates the action of some anticonvulsant drugs in some seizure models. ( Lajtha, A; Toth, E, 1984) |
| "The anticonvulsant activity of a salt of valproic acid (VA), magnesium valproate (MgV), was assessed against amygdala-kindled seizures in rats." | 3.67 | Effect of magnesium valproate on amygdala-kindled seizures in the rat: comparison with sodium valproate. ( Lauretti, L; Palestini, M; Pallini, R; Rossi, GF, 1989) |
| "The anticonvulsive action of diazepam, carbamazepine, sodium valproate and their combinations with pyridoxal-5-phosphate, nicotinamide, and alpha-tocopherol were investigated in acute experiments on mice with corazole-induced seizures." | 3.67 | [Effect of diazepam, carbamazepine, sodium valproate and their combinations with vitamin preparations on epileptic activity]. ( Kryzhanovskiĭ, GN; Shandra, AA, 1985) |
| " Administration of doses established as median therapeutic doses in humans of phenobarbital, valproate and clonazepam to pregnant rats during the last third of gestation produced sexually dimorphic alterations in pentylenetetrazol (PTZ)-induced seizures as well as in non-convulsive (spontaneous alternation and cliff avoidance) behaviors in the offspring." | 3.67 | Prenatal antiepileptic drug exposure alters seizure susceptibility in rats. ( Nandedkar, AK; Sobrian, SK, 1986) |
| "Glutamic acid diethyl ester (GDEE) is a glutamate antagonist which acts preferentially at the quisqualate-sensitive receptor and has been shown to be an effective anticonvulsant in alcohol withdrawal and homocysteine-induced seizures but ineffective in other seizure models." | 3.67 | Inhibition of quisqualate-induced seizures by glutamic acid diethyl ester and anti-epileptic drugs. ( Freed, WJ; Schwarz, SS, 1986) |
| "The effects of chronic treatment with clonazepam and sodium valproate were studied on kindled amygdaloid seizures in rats." | 3.67 | The development of tolerance to the anticonvulsant effects of clonazepam, but not sodium valproate, in the amygdaloid kindled rat. ( Harris, QL; Jarrott, B; Lewis, SJ; Vajda, FJ; Young, NA, 1987) |
| "Six neonates with prolonged, intractable seizures were treated with valproic acid (VPA)." | 3.67 | Valproic acid efficacy, toxicity, and pharmacokinetics in neonates with intractable seizures. ( Gal, P; Gilman, JT; Oles, KS; Weaver, R, 1988) |
| "The relative ability of phenytoin, ethosuximide and valproate to prevent minimal (clonic) threshold, maximal (tonic extension of the hindlimbs) threshold and supramaximal (tonic extension of the hindlimbs) seizures elicited by electrical and chemical (Metrazol, bicuculline, and picrotoxin) stimulation was determined." | 3.67 | Effect of stimulus intensity on the profile of anticonvulsant activity of phenytoin, ethosuximide and valproate. ( Piredda, SG; Swinyard, EA; Woodhead, JH, 1985) |
| "In the course of a large prospective study aimed at evaluating the efficacy of Valproic Acid (VPA) in persons with intractable seizures, six patients that were on a steady dose of diphenylhydantoin (DPH) were exposed to different steady doses of VPA." | 3.67 | Effect of different doses of valproic acid on the serum levels of total and free diphenylhydantoin. ( Alvarez, N, 1985) |
| "Amino acid concentrations were measured in the cortex, cerebellum and hippocampus of the mouse brain before and during seizures induced by isoniazid (250 mg/kg i." | 3.67 | The specific protective effect of diazepam and valproate against isoniazid-induced seizures is not correlated with increased GABA levels. ( Baltzer, V; Bernasconi, R; Jones, RS; Klein, M; Maître, L; Martin, P; Portet, C; Schmutz, M, 1985) |
| " In this model, tonic-clonic seizures are easily elicited by handling and the effects of administration of carbamazepine (CBZ), phenytoin (DPH), phenobarbital (PB), diazepam, valproic acid (VPA) and ethosuximide were quantitatively evaluated." | 3.67 | Seizure control following administration of anticonvulsant drugs in the quaking mouse. ( Abbott, LC; Bennett, GD; Finnell, RH; Taylor, SM, 1985) |
| "A selected group of alkoxy- and halogen-substituted 5-benzylidino- and 5-benzylhydantoins was prepared and screened for anticonvulsant activity as measured by the ability of the compound to prevent maximal electroshock and metrazol-induced threshold clonic seizures in rats." | 3.66 | Potential anticonvulsants. 1. 5-Benzylhydantoins. ( Diuguid, CA; Mehta, NB; Soroko, FE, 1981) |
| "The combined use of di-n-propylacetate with phenazepam, diazepam, phenobarbital or phenytoin was shown to be followed by reciprocal potentiation of the anticonvulsant activity of the drugs in a variety of experimental epileptic seizures in mice according to the tests of shock and antagonism with corasole and thiosemicarbazide." | 3.66 | [Anticonvulsant action of di-N-propylacetate combined with benzodiazepines, phenobarbital and phenytoin]. ( Kosoĭ, MIu, 1981) |
| "Ten analogues of valproic acid (substituted butyric, pentanoic and hexanoic acids) were tested for anticonvulsant activity against audiogenic seizures in DBA/2 mice." | 3.66 | Acute anticonvulsant activity of structural analogues of valproic acid and changes in brain GABA and aspartate content. ( Chapman, AG; Meldrum, BS; Mendes, E, 1983) |
| "5,7-Dihydroxytryptamine (5,7-DHT) injections which caused selective depletion of serotonin in the forebrain enhanced the seizures caused by pentylenetetrazol (PTZ 90 mg/kg s." | 3.66 | Studies on the role of serotonin in different regions of the rat central nervous system on pentylenetetrazol-induced seizures and the effect of di-n-propylacetate. ( Bendotti, C; Lazarova, M; Samanin, R, 1983) |
| "Seven GABAmimetic drugs, namely cetyl gamma-aminobutyric acid (cetyl GABA), 4,5,6,7-tetrahydroisoxazolo [5,4-c]pyridine-3-ol, progabide, aminooxyacetic acid, alpha-acetylenic GABA, (-)-nipecotic acid ethyl ester and (+/-)-cis-4-hydroxynipecotic acid methyl ester, were tested for their potency to block "major" (generalized clonic-tonic) seizures in gerbils, induced by blowing at the animals with compressed air." | 3.66 | High anticonvulsant potency of gamma-aminobutyric acid (GABA)mimetic drugs in gerbils with genetically determined epilepsy. ( Frey, HH; Löscher, W; Reiche, R; Schultz, D, 1983) |
| "The effect of valproic acid and 10 close analogues (7 branched and 3 non-branched) were studied on the content of gamma-aminobutyric acid (GABA) in brain and on seizures induced by pentylenetetrazol (PTZ) in mice." | 3.66 | The effects of analogues of valproic acid on seizures induced by pentylenetetrazol and GABA content in brain of mice. ( Keane, PE; Mendes, E; Morre, M; Santucci, V; Simiand, J, 1983) |
| "An 11-year-old girl with complex seizures was started on valproic acid (VPA) in addition to clonazepam and ethosuximide." | 3.66 | Valproic acid and secondary hyperammonemia. ( Borkowski, WJ; Rawat, S; Swick, HM, 1981) |
| "The anticonvulsant activity of the ethyl esters of the major valproic acid metabolites was assessed against minimal pentylenetetrazol seizures in adult male ICR mice." | 3.66 | Effects of ethyl ester derivatives of valproic acid metabolites on pentylenetetrazol seizures in mice. ( Bruni, J; Hammond, EJ; Wilder, BJ, 1981) |
| "Carbamazepine and valproate each afforded protection against seizures induced by electroshock or by inhalation of hexafluorodiethyl ether (HFDE)." | 3.66 | Interactions between folates and carbamazepine or valproate in the rat. ( Carl, GF; Smith, DB, 1982) |
| "Ethosuximide was identified as the optimal option for new-onset childhood absence epilepsy (CAE) in a randomized, two-phase dose escalation comparative effectiveness trial of ethosuximide, lamotrigine, and valproic acid." | 3.30 | Model-Informed Precision Dosing Guidance of Ethosuximide Developed from a Randomized Controlled Clinical Trial of Childhood Absence Epilepsy. ( Adamson, PC; Blumer, JL; Capparelli, EV; Clark, PO; Cnaan, A; Dong, M; Fukuda, T; Glauser, TA; Mizuno, K; Reed, MD; Shinnar, S; Vinks, AA, 2023) |
| "Seizures are a common complication that leads to neurological deficits and affects outcomes after aneurysmal subarachnoid haemorrhage (aSAH)." | 3.11 | Seizure prophylaxis following aneurysmal subarachnoid haemorrhage (SPSAH): study protocol for a multicentre randomised placebo-controlled trial of short-term sodium valproate prophylaxis in patients with acute subarachnoid haemorrhage. ( Chen, Y; Fang, M; Hu, X; Li, Y; Pang, B; Sun, B; Wu, H; Wu, P; Wu, Q; Xie, Z; Xu, S; You, C; Zhang, J; Zheng, N, 2022) |
| "The classification of seizure types and epilepsies should be examined before selecting the ASMs for each patient with epilepsy." | 3.01 | [Medical Treatment of Epilepsy]. ( Jin, K, 2023) |
| "Epilepsy is a group of neurological diseases characterized by susceptibility to recurrent seizures." | 3.01 | Management of epilepsy during pregnancy and lactation. ( Harris, KM; Hope, OA, 2023) |
| "Primary outcome was seizure cessation for 1h, and secondary outcomes were 24h seizure remission, in-hospital death, and severe adverse events (SAE)." | 2.84 | Comparison of lacosamide versus sodium valproate in status epilepticus: A pilot study. ( Dubey, D; Kalita, J; Misra, UK, 2017) |
| "Epileptic myoclonus or myoclonic seizures can occur in idiopathic generalized epilepsy (IGE) and progressive myoclonus epilepsy (PME)." | 2.82 | A systematic review of the efficacy of perampanel as treatment for myoclonic seizures and symptomatic myoclonus ( Albaradie, R; Alghamdi, A; Alotaibi, M; Alotaibi, W; Bashir, S; Mir, A; Samreen, D, 2022) |
| "The phenytoin treatment causes cerebellar defect and anemia." | 2.82 | The interplay of epilepsy with impaired mitophagy and autophagy linked dementia (MAD): A review of therapeutic approaches. ( Agrawal, M; Dhurandhar, Y; Panda, SP, 2022) |
| "Seizures after intracerebral hemorrhage are a common complication and may adversely affect neurological outcome." | 2.79 | Protocol for seizure prophylaxis following intracerebral hemorrhage study (SPICH): a randomized, double-blind, placebo-controlled trial of short-term sodium valproate prophylaxis in patients with acute spontaneous supratentorial intracerebral hemorrhage. ( Cao, X; Fang, Y; Fu, M; Hu, X; Li, H; Li, X; Lin, S; Liu, M; Liu, W; You, C; Zhang, H, 2014) |
| " However, these medications have several well-known adverse effects." | 2.77 | Efficacy and safety of intravenous sodium valproate versus phenobarbital in controlling convulsive status epilepticus and acute prolonged convulsive seizures in children: a randomised trial. ( Ashrafi, MR; Bavarian, B; Ghaempanah, M; Khosroshahi, N; Malamiri, RA; Nikkhah, A, 2012) |
| "Fifty-two patients with epilepsy of generalized seizures type were randomly divided into an ACCWM group (n=30) and a WM group (n=22)." | 2.76 | [Observation on therapeutic effect of acupoint catgut-embedding combined western medicine for epilepsy of generalized seizures type]. ( Gao, ZG; Mao, ZN; Wang, SB; Zhang, GW, 2011) |
| " Hence intravenous valproate is safe and efficacious, with less time to regain consciousness." | 2.76 | Comparative efficacy and safety of intravenous valproate and phenytoin in children. ( Aggarwal, A; Mittal, H; Rai, A; Sharma, S, 2011) |
| "Patients, aged 8-58 years, with partial epilepsy who did not become seizure free on CBZ were randomized to either VPA add-on or PRM add-on." | 2.74 | Comparison of add-on valproate and primidone in carbamazepine-unresponsive patients with partial epilepsy. ( Deckers, CL; Liu, YX; Sun, MZ; Wang, W, 2009) |
| "To assess changes in seizure frequency, medication side-effects (especially tremor) and formulation preference after switching patients overnight from immediate-release to extended-release divalproex sodium." | 2.74 | Seizure control and side-effect profile after switching adult epileptic patients from standard to extended-release divalproex sodium. ( Brannegan, RT; Evans, AT; Pierre-Louis, SJ, 2009) |
| " The most common treatment-emergent adverse events in the 169 study patients were typical childhood illnesses: pyrexia (18%), cough (17%), and nasopharyngitis (14%)." | 2.74 | Divalproex sodium in children with partial seizures: 12-month safety study. ( Elterman, RD; Lenz, RA; Robieson, WZ; Saltarelli, MD; Vigna, NV, 2009) |
| "The onset of epilepsy is most prevalent between 1 and 3 years of age; however, approximately 25% of patients developed epilepsy before one year of age." | 2.72 | Epilepsy in Angelman syndrome: A scoping review. ( Samanta, D, 2021) |
| "The MESH terms focused on identifying treatments for seizures induced by drugs or other potentially toxic substances." | 2.72 | A systematic review of second line therapies in toxic seizures. ( Alunday, RL; Fletcher, ML; Nash, J; Sarangarm, P; Seifert, SA; Smolinske, SC; Warrick, BJ, 2021) |
| "In patients with newly diagnosed brain tumors who have not had a seizure, clinicians should not prescribe antiepileptic drugs (AEDs) to reduce the risk of seizures (level A)." | 2.72 | SNO and EANO practice guideline update: Anticonvulsant prophylaxis in patients with newly diagnosed brain tumors. ( Avila, EK; Chen, M; Gerstner, ER; Harrison, RA; Kandula, P; Le Rhun, E; Lee, JW; Schiff, D; Stevens, GHJ; Vogelbaum, MA; Walbert, T; Weller, M; Wen, PY; Wick, W, 2021) |
| "Fifty patients with seizures, mean age 8." | 2.72 | Valproic acid monotherapy induces DNA oxidative damage. ( Karikas, GA; Lazaropoulou, C; Margeli, A; Papassotiriou, I; Regoutas, S; Schulpis, KH; Tsakiris, S, 2006) |
| " Patients were converted during an | 2.71 | Lamotrigine monotherapy compared with carbamazepine, phenytoin, or valproate monotherapy in patients with epilepsy. ( Hammer, AE; Kaminow, L; Schimschock, JR; Vuong, A, 2003) |
| "had a 50% or greater decrease in seizure frequency compared with baseline (P<0." | 2.71 | Tiagabine as add-on therapy may be more effective with valproic acid--open label, multicentre study of patients with focal epilepsy. ( Jedrzejczak, J, 2005) |
| "The termination time of seizure, doses of diazepam, mental symptoms and the continual time of mental symptoms were not significantly different among these three groups." | 2.71 | [Evaluation of therapeutic project on acute tetramethylene disulphotetramine poisoning and effect on intelligence in children]. ( Bai, H; Bai, YW; Ding, MB; Ji, JT; Lu, XR; Ma, PB; Sun, CY; Wang, HS; Zhang, HS; Zhang, SL; Zhou, XR, 2005) |
| " A minimum of one steady state trough blood sample and one dosage interval urine were collected during days 3-6 and during days 7-14 post-injury." | 2.69 | Increases in metabolism of valproate and excretion of 6beta-hydroxycortisol in patients with traumatic brain injury. ( Adams, CA; Anderson, GD; Awan, AB; Temkin, NR; Winn, HR, 1998) |
| "There was no significant difference in seizure frequency between the two doses." | 2.69 | Valproate as monotherapy for juvenile myoclonic epilepsy: dose-effect study. ( Lundkvist, B; Sundqvist, A; Tomson, T, 1998) |
| "Afebrile convulsions occurred before the onset of myoclonic seizures or during the clinical course in six patients, but the accurate type of these seizures remains to be clarified." | 2.69 | Benign myoclonic epilepsy in infants: video-EEG features and long-term follow-up. ( Aso, K; Itomi, K; Kuboda, T; Lin, Y; Negoro, T; Okumura, A; Takada, H; Watanabe, K, 1998) |
| "The most important factor determining seizure recurrence was continued therapy, which was the case for barbiturates, phenytoin and valproate." | 2.69 | Does withdrawal of different antiepileptic drugs have different effects on seizure recurrence? Further results from the MRC Antiepileptic Drug Withdrawal Study. ( Chadwick, D, 1999) |
| " The small decreases in mean valproic acid Cmax and AUC0-tau observed during the concomitant administration of tiagabine and valproate are probably of limited clinical importance, given the broad therapeutic range of valproate (50-100 microg/mL)." | 2.69 | Lack of a clinically significant pharmacokinetic drug interaction between tiagabine and valproate. ( Boellner, SW; Granneman, GR; Guenther, HJ; Gustavson, LE; Sommerville, KW; Witt, GF, 1998) |
| " Compliance and adequacy of dosing were assessed by pill counts and monthly blood levels." | 2.68 | A randomized, blinded, placebo-controlled trial of divalproex sodium prophylaxis in adults with newly diagnosed brain tumors. ( Akerley, W; Choy, H; Cole, BF; Friedberg, MH; Furie, K; Glantz, MJ; Lathi, E; Lekos, A; Louis, S; Wahlberg, L, 1996) |
| "Blood levels and seizures were monitored." | 2.68 | Effects of switching from Depakene to generic valproic acid on individuals with mental retardation. ( Kraushaar, KW; Vadney, VJ, 1997) |
| " In 2009, a review was published providing guidance for the dosing and therapeutic drug monitoring of antiepileptic drugs during pregnancy." | 2.66 | Therapeutic Drug Monitoring of Antiepileptic Drugs in Women with Epilepsy Before, During, and After Pregnancy. ( Arfman, IJ; Lambrechts, DA; Ter Horst, PGJ; Touw, DJ; Wammes-van der Heijden, EA; Wegner, I, 2020) |
| "The incidence of seizures following supratentorial craniotomy for non-traumatic pathology has been estimated to be between 15% to 20%; however, the risk of experiencing a seizure appears to vary from 3% to 92% over a five-year period." | 2.66 | Antiepileptic drugs as prophylaxis for postcraniotomy seizures. ( Dundar, Y; Greenhalgh, J; Marson, AG; Nevitt, SJ; Weston, J, 2020) |
| " The dosage was phenobarbitone 3-6 mg/kg per day; sodium valproate 30-60 mg/kg per day." | 2.65 | Continuous sodium valproate or phenobarbitone in the prevention of 'simple' febrile convulsions. Comparison by a double-blind trial. ( Bower, B; Ngwane, E, 1980) |
| "The occurrence of seizures and other withdrawal symptoms (tremulousness, nausea, sweating, disorientation) were noted daily." | 2.65 | Sodium valproate in the treatment of the alcohol withdrawal syndrome. ( Johnson, RH; Lambie, DG; Vijayasenan, ME; Whiteside, EA, 1980) |
| "Over time, with careful delineation of Dravet syndrome, we have gained experience in treatments most likely to lead to improvement in seizures, as well as those that should be avoided." | 2.61 | Dravet syndrome: Treatment options and management of prolonged seizures. ( Caraballo, RH; Cross, JH; Guerrini, R; Lagae, L; Nabbout, R; Vigevano, F, 2019) |
| "Carbamazepine (CBZ) was found to be effective in most cases." | 2.61 | Epilepsy in patients with EAST syndrome caused by mutation in the KCNJ10. ( Albaradie, R; Alhazmi, R; Alkhaldi, H; Chaudhary, M; Housawi, Y; Mir, A, 2019) |
| "Very little has been written on seizure management in palliative care (PC)." | 2.61 | Guidelines for seizure management in palliative care: Proposal for an updated clinical practice model based on a systematic literature review. ( Arce Arce, S; Benito-León, J; García-Albea Ristol, E; Ibáñez Estéllez, F; León Ruiz, M; Pérez Nieves, MT; Rodríguez Sarasa, ML; Sanjuán Rodríguez, L, 2019) |
| "Postoperative seizures can precipitate the development of epilepsy; seizures are most likely to occur within the first month of cranial surgery." | 2.58 | Antiepileptic drugs as prophylaxis for postcraniotomy seizures. ( Dundar, Y; Greenhalgh, J; Marson, AG; Nevitt, SJ; Weston, J, 2018) |
| "The use of AEDs for purposes other than seizure prophylaxis and their selection based on non-PK properties present a potential paradigm shift in the field of neuro-oncology." | 2.53 | Antiepileptic drugs in patients with malignant brain tumor: beyond seizures and pharmacokinetics. ( Gefroh-Grimes, HA; Gidal, BE, 2016) |
| "A meta-analysis found higher rates of seizure cessation with valproate 75." | 2.53 | Pharmacologic treatment of status epilepticus. ( Brigo, F; Höfler, J; Kalss, G; Leitinger, M; Rohracher, A; Trinka, E, 2016) |
| "Reflex epileptic seizures can often be prevented by avoidance or modification of triggers or by prophylactic benzodiazepine administration." | 2.53 | Reflex epileptic mechanisms in ictogenesis and therapeutic consequences. ( Guaranha, M; Lin, K; Wolf, P, 2016) |
| "The aim of this review was to evaluate current literature for dosing recommendations for the use of antiepileptic medications in patients receiving renal replacement therapy (RRT)." | 2.53 | Antiepileptic dosing for critically ill adult patients receiving renal replacement therapy. ( Bastin, ML; Cook, AM; Oyler, DR; Smetana, KS, 2016) |
| "The incidence of seizures following supratentorial craniotomy for non-traumatic pathology has been estimated to be between 15% to 20%; however, the risk of experiencing a seizure may vary from 3% to 92% over a five-year period." | 2.52 | Antiepileptic drugs as prophylaxis for post-craniotomy seizures. ( Greenhalgh, J; Marson, AG; Weston, J, 2015) |
| "Full seizure control in the pre-pregnancy year, and adjusting antiepileptic drug doses to maintain plasma drug concentrations throughout pregnancy at values associated with seizure control before pregnancy, have major influences in preserving seizure control during pregnancy." | 2.50 | Treating epilepsy in pregnant women. ( Eadie, MJ, 2014) |
| "Occurrence of generalized tonic-clonic seizures (GTCS) is one of the most important risk factors of seizure-related complications and comorbidities in patients with epilepsy." | 2.50 | Pharmacotherapy for tonic-clonic seizures. ( Rheims, S; Ryvlin, P, 2014) |
| "The incidence of seizures following supratentorial craniotomy for non-traumatic pathology has been estimated to be 15% to 20%; however, the risk of experiencing a seizure may vary from 3% to 92% over a five-year period." | 2.49 | Antiepileptic drugs as prophylaxis for post-craniotomy seizures. ( Greenhalgh, J; Marson, AG; Pulman, J, 2013) |
| "Seizures and intracranial hemorrhage are possible medical diseases that any obstetrician may encounter." | 2.49 | Seizures and intracranial hemorrhage. ( Alexander, JM; Wilson, KL, 2013) |
| "A total of 8 cases of seizures after allo-HSCT were investigated." | 2.49 | Analysis of seizure risk factors after allogeneic hematopoietic stem cell transplantation: a 8 case report and literature review. ( Li, L; Li, WM; Wu, YH; You, Y; Zhong, ZD; Zou, P, 2013) |
| "Absence seizures have a significant impact on quality of life." | 2.49 | Absence seizures in children. ( Posner, E, 2013) |
| "Acute seizure and status epilepticus constitute one of the major medical emergencies in children." | 2.48 | Management of acute seizure and status epilepticus in pediatric emergency. ( Sasidaran, K; Singhi, P; Singhi, S, 2012) |
| "Studies on mechanisms of seizure generation and propagation have identified new potential targets for AEDs." | 2.45 | New antiepileptic drugs: molecular targets. ( Mula, M, 2009) |
| "Five patients (83%) experienced generalized seizures during concurrent VPA-carbapenem treatment, including two with no prior history of seizures or epilepsy." | 2.45 | Valproic acid-carbapenem interaction: report of six cases and a review of the literature. ( Golightly, LK; Jones, MA; Kick, SD; Tobin, JK, 2009) |
| "Both seizures and antiepileptic drugs may induce disturbances in hormonal system." | 2.44 | [Endocrine effects of antiepileptic drugs]. ( Budziszewska, B; Lasoń, W; Leśkiewicz, M, 2008) |
| " Such aggravation may be due to a variety of factors that include a paradoxical pharmacodynamic effect." | 2.42 | Antiepileptic drug-induced pharmacodynamic aggravation of seizures: does valproate have a lower potential? ( Genton, P; Hirsch, E, 2003) |
| "Minimal requirements: seizure-prevention outcome given as fraction of cases; AED or control assigned by random or quasi-random mechanism." | 2.41 | Antiepileptogenesis and seizure prevention trials with antiepileptic drugs: meta-analysis of controlled trials. ( Temkin, NR, 2001) |
| "Febrile seizures are the most common seizures in childhood and, like all seizures, can be frightening to witness." | 2.41 | Prevention and management of febrile seizures. ( Baumann, RJ, 2001) |
| "Fosphenytoin has recently been approved as a substitute for parenteral phenytoin." | 2.40 | New drug therapy for acute seizure management. ( Morton, LD; Pellock, JM; Rizkallah, E, 1997) |
| "Successful control of seizures with anticonvulsant drugs reflects a balance in achieving seizure control while minimizing undesirable drug side effects." | 2.40 | Anticonvulsant therapy in small animals. ( Boothe, DM, 1998) |
| "Neocortical focal seizures are characterized by motor jerks in one limb (Jacksonian type), head turning (adversive attack), or localized sensory manifestations, and limbic or psychomotor attacks by brief impairment of consciousness and often by motor automatisms." | 2.37 | [Therapy of brain-related minor seizures]. ( Hess, CW, 1988) |
| "Valproic acid is a new antiepileptic drug." | 2.36 | Valproic acid. Review of a new antiepileptic drug. ( Bruni, J; Wilder, BJ, 1979) |
| "Forty patients (39." | 1.91 | Epilepsy and pregnancy. Factors associated with epileptic seizures during pregnancy. ( Barambio, S; Becerra, JL; Chíes, E; Ciurans, J; Codina, M; Fumanal, A; García-Esperón, C; Grau-López, L; Jiménez, M, 2023) |
| "PTZ gradually provoked seizure-related behaviors." | 1.91 | The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure. ( Abnous, K; Gorji Valokola, M; Heydari, FS; Mehri, S; Roohbakhsh, A, 2023) |
| "Nocturnal epilepsy is a neurological disease that has a significant effect on sleep." | 1.91 | Effect of valproate on sleep patterns disturbed by epilepsy. ( Ayala-Guerrero, F; Castro-Domínguez, D; Gutiérrez-Chávez, CA; Mateos-Salgado, EL; Mexicano-Medina, G, 2023) |
| "Overall, only 24% of the 759 reported seizures had an associated EEG correlate, indicating a high over-reporting rate, which occurred in 57% of patients." | 1.91 | How accurately do adult patients report their absence seizures? ( O'Sullivan, S; Pizarro, J; Walker, MC, 2023) |
| "Epilepsy is characterized by the manifestation of spontaneous and recurrent seizures." | 1.91 | The Effect of Adenosine Signaling on Memory Impairment Induced by Pentylenetetrazole in Zebrafish. ( Bertoncello, KT; Bonan, CD, 2023) |
| "Prescriptions for non-seizure indications increased from 7% in children aged 6 years or under to 31% in 16- to 18-year-olds." | 1.91 | Indications and prescribing patterns of antiseizure medications in children in New Zealand. ( Ali, S; Davis, S; Keenan, N; Sadleir, LG; Scheffer, IE; Stanley, J, 2023) |
| "Aripiprazole (APZ) is an atypical antipsychotic that can safeguard mice against autism-like behavior induced by valproic acid (VPA)." | 1.91 | Maternal treatment with aripiprazole prevents the development of a valproic acid-induced autism-like phenotype in juvenile male mice. ( de Andrade, GM; de Barros Viana, GS; de Oliveira Ferreira, E; Lima, FAV; Neves, KRT; Pessoa Gomes, JM, 2023) |
| "Epilepsy with myoclonic atonic seizures (EMAtS) was previously thought to occur in normally developing children." | 1.91 | A case of epilepsy with myoclonic atonic seizures caused by SLC6A1 gene mutation due to balanced chromosomal translocation. ( Fujita, A; Goji, A; Matsumoto, N; Mizuguchi, T; Mori, T; Sakamoto, M; Tayama, T; Toda, Y; Urushihara, M, 2023) |
| "We related seizure control to VPA doses through uni- and multivariate statistical analyses." | 1.91 | Minimum effective sodium valproate dose in genetic generalized epilepsies. ( Bittar Guaranha, MS; Duarte, JTC; Guilhoto, LM; Hackbart, BA; Marques, VD; Peixoto-Santos, JE; Yacubian, EMT, 2023) |
| "Gender, seizure onset age, psychiatric diseases, seizure characteristics (semiology, duration, and relationship to sleep), last EEG time, and spike lateralization in the first EEG did not have a statistically significant effect on the SWI change." | 1.91 | The fate of spikes in self-limited epilepsy with centrotemporal spikes: Are clinical and baseline EEG features effective? ( Günay, Ç; Hiz Kurul, S; Özsoy, Ö; Sarikaya Uzan, G; Yiş, U, 2023) |
| "Studies have reported a recurrence rate ranging from 21%-50%, but most have included patients with different etiologies, electroencephalography (EEG) findings, and seizure types." | 1.91 | Risk of recurrence in patients with an unprovoked tonic-clonic seizure and generalized epileptiform discharges on EEG. ( Beaini, S; Beydoun, A; Hmeimess, G; Hotait, M; Jomaa, N; Nasreddine, W; Wazne, J, 2023) |
| " A major challenge lies in the lack of knowledge about the bioavailability and pharmacodynamic effects of bioactive compounds in this model organism." | 1.91 | Pharmacometabolic Effects of Pteryxin and Valproate on Pentylenetetrazole-Induced Seizures in Zebrafish Reveal Vagus Nerve Stimulation. ( Budzyńska, B; Gertsch, J; Kozioł, E; Lee, SM; Morozova, V; Pellegata, D; Skalicka-Woźniak, K; Skiba, A, 2023) |
| "To evaluate Epileptic drop attacks (EDAs) treatment options among pediatric neurologists in Saudi Arabia (SA) and to develop a recommendation scheme for the management of EDAs in SA." | 1.91 | Treatment of drop attacks: Anti-seizure drug choices of pediatric neurologists in Saudi Arabia. ( Abbar, A; Abdulsbhan, M; Alelyani, R; Alhiniah, M; Alrajhi, A; Alshahrani, A; Badawi, A; Jan, M; Muthaffar, O; Rajab, R, 2023) |
| " We should collaborate with obstetricians and other professionals to help ensure a safe environment for pregnancy and childbirth." | 1.91 | [Safe and Effective Management of Epilepsy in Pregnancy]. ( Iwasaki, M; Kimura, Y, 2023) |
| "The seizures were refractory to most anti-epileptic drugs but showed some response to Valproic acid." | 1.91 | Potassium Channel Subfamily T Member 1(KCNT1) Pathological Variant Causing Epilepsy Of Infancy With Migrating Focal Seizures: A Case Report. ( Angez, M; Chand, P; Hameed, AN; Kirmani, S, 2023) |
| "However, with chronic treatment, antiseizure effects are lost as tolerance develops." | 1.91 | Long-lasting antiseizure effects of chronic intrasubthalamic convection-enhanced delivery of valproate. ( Deking, L; Feja, M; Felmy, F; Gernert, M; Javadova, A; MacKeigan, D; Meller, S; Veenhuis, A, 2023) |
| "Idiopathic generalized epilepsy with phantom absences, absence status, and generalized tonic-clonic seizures is an extremely rare condition." | 1.91 | Idiopathic generalized epilepsy with phantom absences, absence status, and generalized tonic-clonic seizures: A case report. ( Jiang, Y; Zhou, X, 2023) |
| "Stroke is the leading cause of epilepsy in the elderly, ahead of degenerative diseases, tumors and head injuries." | 1.91 | Post-stroke seizures: risk factors and management after ischemic stroke. ( Derbali, H; Mansour, M; Messelmani, M; Mrissa, N; Mrissa, R; Ouerdiene, A; Zaouali, J, 2023) |
| "Absence seizures were significantly associated with no-remission at multivariable multinomial logistic regression analysis." | 1.72 | Seizure outcome trajectories in a well-defined cohort of newly diagnosed juvenile myoclonic epilepsy patients. ( Cerulli Irelli, E; Di Bonaventura, C; Fanella, M; Fattouch, J; Giallonardo, AT; Manfredi, M; Morano, A; Orlando, B; Salamone, EM, 2022) |
| "A case of valproate induced acute pancreatitis operated as surgical abdomen has been reported here." | 1.72 | Valproate Induced Acute Pancreatitis - A Unique Case Report. ( Chauhan, V; Garg, GK; Kapur, A; Sharma, M, 2022) |
| " Hence, reducing VPA dosage to minimize side effects while maintaining its efficacy is necessary, and transcranial photobiomodulation (tPBM) add-on therapy could facilitate this." | 1.72 | Transcranial photobiomodulation add-on therapy to valproic acid for pentylenetetrazole-induced seizures in peripubertal rats. ( Chang, H; Chang, SF; Tsai, CM, 2022) |
| "Patients with juvenile myoclonic epilepsy (JME) are especially prone to having antiseizure medications (ASMs) withdrawal seizures (WS)." | 1.72 | Antiseizure Medications Withdrawal Seizures in Patients with Juvenile Myoclonic Epilepsy. ( Ekstein, D; Eyal, S; Hofi, E; Khana Levy, N; Medvedovsky, M; Nassar, M, 2022) |
| "This study aimed to evaluate antiseizure medication (ASM) use in patients with JME." | 1.72 | Trends in the choice of antiseizure medications in juvenile myoclonic epilepsy: A retrospective multi-center study from Turkey between 2010 and 2020. ( Aydın, K; Cansu, A; Esenülkü, G; Haspolat, Ş; İnce, T; Kılıç, B; Okuyaz, Ç; Polat, BG; Serdaroğlu, A; Serdaroğlu, E; Tekgül, H; Topçu, Y, 2022) |
| "Specific antiseizure medications (ASM) would improve the outcome in post-stroke epilepsy (PSE)." | 1.72 | Efficacy and safety of antiseizure medication in post-stroke epilepsy. ( Groppa, S; Klimpe, S; Sandner, K; Stuckrad-Barre, SV; Uphaus, T; Winter, Y, 2022) |
| "Idiopathic Generalized Epilepsy (IGE) patients may not achieve optimal seizure control with monotherapy." | 1.72 | Seizure control in mono- and combination therapy in a cohort of patients with Idiopathic Generalized Epilepsy. ( Castro, LHM; Pipek, HZ; Pipek, LZ, 2022) |
| "Evidence for treating seizures in AS mainly derives from low-quality studies." | 1.72 | Pharmacotherapeutic management of seizures in patients with Angleman Syndrome. ( Samanta, D, 2022) |
| "The most common cause of seizures is epilepsy." | 1.72 | [Prospects for the development of new prolonged forms of valproic acid derivatives for the relief of convulsive syndrome]. ( Bespalov, AY; Krasnov, KA; Melekhova, AS; Reinuk, VL; Zorina, VN, 2022) |
| "After several years without seizures, 24 out of 30 had a relapse, which was quickly stopped in 23 out of 30 patients." | 1.72 | [Epilepsy in Angelman syndrome]. ( Bobylova, MY; Glukhova, LY; Kuzmich, GV; Mukhin, KY; Pylayeva, OA, 2022) |
| "Palliative care patients experience seizures in different stages of their disease and may not tolerate oral medications toward the end of life." | 1.72 | Subcutaneous Levetiracetam and Sodium Valproate Use in Palliative Care Patients. ( Bradley, K; Kondasinghe, JS; Look, ML; Moffat, P, 2022) |
| "The switch between nonseizure and seizure states involves profound alterations in network excitability and synchrony." | 1.72 | Elevated photic response is followed by a rapid decay and depressed state in ictogenic networks. ( D'gama, PP; Hoffshagen, HH; Hotz, AL; Jamali, A; Jurisch-Yaksi, N; Mutlu, AK; Myren-Svelstad, S; Neuhauss, SCF; Ophus, SS; Ostenrath, AM; Yaksi, E, 2022) |
| "While the proband attained seizure control with sodium valproate, his mother's seizures were not well controlled." | 1.72 | A heterozygous missense variant in the YWHAG gene causing developmental and epileptic encephalopathy 56 in a Chinese family. ( Feng, X; Li, F; Pan, H; Song, Z; Xue, J; Yang, C; Yi, Z; Zhang, Y, 2022) |
| "Female patients with genetic generalized epilepsy who were followed up in our centre were included in the study." | 1.72 | Our reasons for converting to valproic acid treatment in female patients with genetic generalized epilepsy: a retrospective, single-centre study. ( Baklan, B; Mermi Dibek, D; Öztura, İ, 2022) |
| "Valproic acid (VPA) is an antiepileptic drug, used for focal and generalized seizure." | 1.72 | The impact of valproic acid treatment on weight gain in pediatric patients with epilepsy. ( Battaglia, D; Blasi, V; DI Ruscio, F; Ferrara, P; Gatto, A, 2022) |
| "Herein, we present a 13-year-old generalized epilepsy patient with eating-induced generalized seizures since the age of 5." | 1.62 | Eight years follow-up of a generalized epilepsy patient with eating-induced late-onset epileptic spasms and atypical absence with myoclonic jerks. ( Chen, B; Jin, L; Liu, Y; Wang, X; Zhang, W, 2021) |
| "Protective (antiseizure) effects of 4-butyl-5-[(4-chloro-2-methylphenoxy)-methyl]-2,4-dihydro-3H-1,2,4-triazole-3-thione (TPL-16) and acute neurotoxic effects were determined in the tonic-clonic seizure model and rotarod test in mice." | 1.62 | Anticonvulsant Effectiveness and Neurotoxicity Profile of 4-butyl-5-[(4-chloro-2-methylphenoxy)methyl]-2,4-dihydro-3H-1,2,4-triazole-3-thione (TPL-16) in Mice. ( Drabik, M; Florek-Łuszczki, M; Głuszak, M; Jankiewicz, M; Kozińska, J; Plech, T; Plewa, Z; Wróblewska-Łuczka, P; Łuszczki, JJ, 2021) |
| "Under lamotrigine, seizure aggravation was observed in 15 patients (two patients during levetiracetam, one patient during zonisamide, none during phenobarbital and valproic acid)." | 1.62 | Risk factors of paradoxical reactions to anti-seizure medication in genetic generalized epilepsy. ( Beier, CP; Gesche, J; Hjalgrim, H; Rubboli, G, 2021) |
| "Seizures were classified as early seizure (first seizure within 1 week of ICH), delayed seizure (first seizure after 1 week), and late seizure (any seizure after 1 week)." | 1.62 | Discontinuation of preventive antiepileptic drugs in patients with intracerebral hemorrhage. ( Ong, CT; Wong, YS; Wu, CS, 2021) |
| "Four (80%) had a referral diagnosis of focal epilepsy based on historical focal features with exacerbation of seizures on oxcarbazepine." | 1.62 | Unmasking the entity of 'drug-resistant' perioral myoclonia with absences: the twitches, darts and domes! ( Er, S; Menon, RN; Radhakrishnan, A; Rudrabhatla, PK, 2021) |
| "Fenfluramine (FFA), an antiseizure medication (ASM) indicated for treating convulsive seizures in Dravet syndrome, was assessed in six patients (five female; 83%) with CDD whose seizures had failed 5-12 ASMs or therapies." | 1.62 | Effect of fenfluramine on convulsive seizures in CDKL5 deficiency disorder. ( Conway, E; Devinsky, O; King, L; Price, D; Schwartz, D, 2021) |
| "Clinical outcome was seizure control during the 6 months observation period." | 1.62 | Association of UGT1A6 gene polymorphism with clinical outcome in pediatric epileptic patients on sodium valproate monotherapy. ( Adiga, S; Adiga, U; Banawalikar, N; Kumari, S; Sharmila, KP; Shenoy, V; Shetty, P; Shetty, S, 2021) |
| "Levetiracetam (LEV) is a second-generation antiseizure medicine (ASM) with broad-spectrum efficacy and tolerability." | 1.62 | Initial levetiracetam versus valproate monotherapy in antiseizure medicine (ASM)-naïve pediatric patients with idiopathic generalized epilepsy with tonic-clonic seizures. ( Abdelmesih, SK; Elkhateeb, N; Girgis, MY; Zakaria, M, 2021) |
| "Chronic post-hypoxic myoclonus is a condition in which the predominant clinical picture is myoclonus following hypoxic brain damage, usually due to cardiorespiratory arrest." | 1.62 | [Response to perampanel in a patient with chronic post-hypoxic myoclonus]. ( de Toledo, M; Muro-García, I; Pastor, J; Vega, L; Vieira, A, 2021) |
| "The effect of VAL vs CMZP/OX on seizure threshold was examined using multivariable regression with adjustment for confounders." | 1.62 | Carbamazepine/oxcarbazepine and valproate have different effects on the electroconvulsive therapy seizure threshold. ( Andrade, C; Ibrahim, FA; Pahuja, E; Thirthalli, J, 2021) |
| "Even though Epilepsy is a significant clinical issue in ATP1A3 patients, only a minority of publications provide any information about patients' anti-epileptic treatment." | 1.56 | ATP1A3-related epilepsy: Report of seven cases and literature-based analysis of treatment response. ( Abicht, A; Biskup, S; Boonsimma, P; Borggraefe, I; Gasser, M; Ittiwut, C; Krenn, M; Kuersten, M; Milenkovic, I; Netbaramee, W; Roser, T; Shotelersuk, V; Srichomthomg, C; Suphapeetiporn, K; Tacke, M; von Stülpnagel, C; Wagner, M; Wechapinan, T; Zimprich, F, 2020) |
| "We also studied the seizure outcome in patients with IGEs." | 1.56 | Tonic-clonic seizures in idiopathic generalized epilepsies: Prevalence, risk factors, and outcome. ( Asadi-Pooya, AA; Homayoun, M, 2020) |
| "Carbamazepine was ineffective, and seizures were exacerbated with levetiracetam (LEV)." | 1.56 | Improvement of epilepsy with lacosamide in a patient with ring chromosome 20 syndrome. ( Goji, A; Kagami, S; Mori, T; Tayama, T; Toda, Y, 2020) |
| "Prepregnancy reduction in VPA dosage reduced the hazard of fetal malformations, whereas ceasing intake of the drug decreased the hazard to one similar to that which applies in the general population, but at a cost of decreased control of epileptic seizures during the pregnancies studied." | 1.56 | Pregnancy after valproate withdrawal-Fetal malformations and seizure control. ( Eadie, MJ; Graham, JE; Hitchcock, AA; Lander, CM; O'Brien, TJ; Vajda, FJE, 2020) |
| "The risk of seizure relapse was estimated as 43." | 1.56 | Antiepileptic drugs for acute encephalitic patients presented with seizure. ( Chen, L; He, S; Lai, W; Li, W; Peng, A; Qiu, X; Zhang, L, 2020) |
| " Both, the type I isobolographic analysis and the test of parallelism of dose-response effects of the ASDs were used so as to properly classify interaction among three ASDs, administered in a fixed ratio combination of 1:1:1." | 1.56 | Sub-additive (antagonistic) interaction of lacosamide with lamotrigine and valproate in the maximal electroshock-induced seizure model in mice: an isobolographic analysis. ( Bojar, H; Florek-Łuszczki, M; Karwan, S; Kondrat-Wróbel, M; Plewa, Z; Zagaja, M; Łuszczki, JJ, 2020) |
| "Idiopathic Generalized Epilepsy (IGE) management has become increasingly challenging due to the restricted use of Valproate (VPA) in females." | 1.56 | Valproate impact and sex-dependent seizure remission in patients with idiopathic generalized epilepsy. ( Albini, M; Barone, FA; Casciato, S; Cerulli Irelli, E; Cocchi, E; Di Bonaventura, C; Di Gennaro, G; Fanella, M; Fattouch, J; Fisco, G; Giallonardo, AT; Manfredi, M; Mascia, A; Morano, A; Orlando, B, 2020) |
| " This study investigated the effect of delayed or missed doses on the pharmacokinetics (PK) of valproic acid (VPA) in patients with epilepsy and established remedial dosing recommendations for nonadherent patients." | 1.56 | Remedial dosing recommendations for delayed or missed doses of valproic acid in patients with epilepsy based on Monte Carlo simulations. ( Ding, JJ; Jiao, Z; Wang, CY; Yu, EQ; Zhu, GX, 2020) |
| "Levetiracetam has replaced sodium valproate as the most frequently prescribed ASM in pediatric patients." | 1.56 | Trends of anti-seizure medication use in pediatric patients in six cities in China from 2013 to 2018. ( Dai, H; Feng, J; Yu, L; Yu, Z, 2020) |
| "Valproic acid (VPA) is a widely used anti-epileptic drug (AED) of demonstrated efficacy." | 1.56 | Risk-benefit assessment of treatment of epileptic women of childbearing age with valproic acid. ( Baraldés-Rovira, M; Gallego, Y; Mauri-Capdevila, G; Purroy, F; Quílez, A; Sanahuja, J, 2020) |
| "Valproic acid was less frequently prescribed to female patients." | 1.56 | Observational multicentre study into the use of antiepileptic drugs in Spanish neurology consultations. ( Campos Blanco, DM; Castro Vilanova, MD; López Gonzalez, FJ; Mercadé Cerdá, JM; Querol Pascual, MR; Serrano Castro, P, 2020) |
| "Epilepsy was present in 29." | 1.51 | [Epilepsy in children with congenital hemiparesis secondary to perinatal ictus]. ( Alonso, X; Campistol, J; Escofet, C; Fons, C; Macaya, A; Revilla Orías, MD, 2019) |
| "Olanzapine is a second-generation antipsychotic." | 1.51 | Generalised tonic-clonic seizures on the subtherapeutic dose of olanzapine. ( Chachar, AS; Mansoor, M; Mesiya, MH, 2019) |
| "The predominant seizure types in NLLOE were focal to bilateral tonic-clonic seizures (30%) as well as focal onset impaired awareness motor seizures (IAMS) (22%) and focal onset impaired awareness nonmotor seizures (IANMS) (22%)." | 1.51 | Nonlesional late-onset epilepsy: Semiology, EEG, cerebrospinal fluid, and seizure outcome characteristics. ( Flöel, A; Hamann, L; Süße, M; von Podewils, F, 2019) |
| " In children under 2 years old, serious adverse effects are appear to be more frequent." | 1.51 | Adverse Effects of Treatment with Valproic Acid during the Neonatal Period. ( Baudou, E; Benevent, J; Hachon LeCamus, C; Montastruc, JL; Touati, G, 2019) |
| "The 6-Hz psychomotor seizure induced ultra-structural changes in both cortex and hippocampus in mice treated with PCPA." | 1.51 | Serotonergic mechanisms in the 6-Hz psychomotor seizures in mice. ( Jahan, K; Pillai, KK; Vohora, D, 2019) |
| "Epileptic seizures were primary tonic-clonic (67." | 1.51 | Accidental injuries in patients with generalized tonic-clonic seizures. A multicenter, observational, cross-sectional study (QUIN-GTC study). ( Abraira, L; Iniesta, M; Puig, J; Salas-Puig, X, 2019) |
| "Postcranioplasty seizures, especially early seizures, are common and associated with poor outcomes and longer hospital stays." | 1.51 | A Novel Protocol to Reduce Early Seizures After Cranioplasty: A Single-Center Experience. ( Chen, CC; Chen, CT; Hsieh, PC; Lai, HY; Lee, CY; Liu, YT; Liu, ZH; Tu, PH; Wu, CT; Yeap, MC, 2019) |
| "Epileptic seizures are frequent in patients with glioblastoma, and anticonvulsive treatment is often necessary." | 1.51 | AMPA receptor antagonist perampanel affects glioblastoma cell growth and glutamate release in vitro. ( Bergner, C; Hörnschemeyer, J; Kirschstein, T; Köhling, R; Krause, BJ; Lange, F; Linnebacher, M; Mullins, CS; Porath, K; Weßlau, K, 2019) |
| "Hyperhomocysteinemia is found to be closely associated with an enhanced risk of cerebral venous thrombosis." | 1.51 | An uncommon presentation of hyperhomocysteinemia and vitamin B ( D'Cruz, S; Kapur, V; Kaur, R, 2019) |
| "Electrically-induced tonic-clonic seizures were experimentally evoked in adult male albino Swiss mice." | 1.51 | New derivative of 1,2,4-triazole-3-thione (TP427) potentiates the anticonvulsant action of valproate, but not that of carbamazepine, phenytoin or phenobarbital in the mouse tonic-clonic seizure model. ( Gut-Lepiech, A; Karwan, S; Kondrat-Wróbel, MW; Marzeda, P; Plech, T; Wróblewska-Łuczka, P; Łuszczki, JJ, 2019) |
| "An increase in myoclonus, resulting from the progressive nature of the disease leads to significant disability in the majority of patients." | 1.51 | Unverricht-Lundborg disease: Clinical course and seizure management based on the experience of polish centers. ( Bosak, M; Lasek-Bal, A; Lukasik, M; Sulek, A; Żak, A, 2019) |
| "The patient had initial seizures during sleep at the age of 1 year, with the left mouth pouting, left eye blinking and drooling for several seconds, and, sometimes, the left upper-limb flexion and head version to the left, lasting for 1-2 min." | 1.51 | Acquired epileptiform opercular syndrome evaluated with real-time transcranial Doppler ultrasound-video-electroencephalogram before and after treatment: a case report. ( Chen, WX; Li, JL; Liang, HC; Liang, W; Peng, BW; Yang, SY; Zhang, FQ, 2019) |
| "The intractable seizures showed complete but transient responsiveness to pyridoxal phosphate and finally controlled by valproate treatment." | 1.51 | ARX-associated infantile epileptic-dyskinetic encephalopathy with responsiveness to valproate for controlling seizures and reduced activity of muscle mitochondrial complex IV. ( Chu, VL; Fung, CW; Kwong, AK; Rodenburg, RJT; Smeitink, J, 2019) |
| "We studied an observational cohort of comatose subjects treated at a single academic medical center after cardiac arrest from September 2010 to January 2018." | 1.51 | Association of antiepileptic drugs with resolution of epileptiform activity after cardiac arrest. ( Baldwin, MA; Callaway, CW; Coppler, PJ; Elmer, J; Kvaløy, JT; Solanki, P, 2019) |
| "Patients with juvenile myoclonic epilepsy (JME) may have uncontrolled seizures." | 1.51 | Treatment and challenges with antiepileptic drugs in patients with juvenile myoclonic epilepsy. ( Baftiu, A; Enger, U; Fløgstad, I; Johannessen Landmark, C; Johannessen, SI; Koht, J; Syvertsen, M, 2019) |
| "However, seizures are not typical and the majority of them were seizure-free." | 1.51 | A 16q22.2-q23.1 deletion identified in a male infant with West syndrome. ( Goji, A; Imoto, I; Ito, H; Kagami, S; Kohmoto, T; Mori, K; Mori, T; Toda, Y, 2019) |
| "Curcumin is a phytochemical with promising effects on epilepsy treatment." | 1.48 | Micronization potentiates curcumin's anti-seizure effect and brings an important advance in epilepsy treatment. ( Aguiar, GPS; Bertoncello, KT; Oliveira, JV; Siebel, AM, 2018) |
| "Carbamazepine was the most chosen antiepileptic drug for secondary prophylaxis, followed by valproate acid, and levetiracetam." | 1.48 | [A nationwide multi-center questionnaire survey on the management and treatment of post-stroke seizure and epilepsy in Japan]. ( Abe, S; Fukuma, K; Higashida, K; Ihara, M; Nagatsuka, K; Okuno, Y; Tanaka, T; Tomari, S; Toyoda, K; Yamagami, H, 2018) |
| "A total of 174 children with generalized seizures on VPA therapy were enrolled." | 1.48 | Effects of UGT2B7, SCN1A and CYP3A4 on the therapeutic response of sodium valproate treatment in children with generalized seizures. ( Fang, F; Feng, W; Gao, B; Mei, S; Wu, X; Yang, W; Yu, Y; Zhao, Z; Zhu, L, 2018) |
| "This case report describes a case of influenza B-related meningoencephalitis supported by evidence of an influenza B infection and temporal relation of the neurological event and respiratory illness in the absence of other identifiable cause." | 1.48 | Influenza B-related meningoencephalitis in adults. ( Norton, G; Vallat, W; Yong, CH, 2018) |
| "This was followed by a tonic-clonic seizure." | 1.48 | [Two cases of photosensitive seizure induced by barcode readers with red flashing lights]. ( Kawamata, J; Shimohama, S; Toyama, Y, 2018) |
| "The current study evaluates the anticonvulsant effect of valproic acid (VPA) alone or combined with low dose γ-irradiation (LDR) against pentylenetetrazol-induced convulsions in rats." | 1.48 | Effect of valproic acid alone or combined with low dose gamma irradiation in modulating PTZ-induced convulsions in rats involving AKT/m-TOR pathway. ( Kenawy, SA; Lotfy, DM; Mohamed, SH; Safar, MM, 2018) |
| "The primary outcome was the number of seizures in the past month (30 days)." | 1.48 | Asymptomatic malaria parasitaemia and seizure control in children with nodding syndrome; a cross-sectional study. ( Akun, P; Anguzu, R; Idro, R; Kayongo, E; Marsh, K; Newton, CRJC; Ningwa, A; Ogwang, R, 2018) |
| "Early myoclonus after cardiac arrest (CA) is traditionally viewed as a poor prognostic sign (status myoclonus)." | 1.46 | Early Lance-Adams syndrome after cardiac arrest: Prevalence, time to return to awareness, and outcome in a large cohort. ( Aicua Rapun, I; Novy, J; Oddo, M; Rossetti, AO; Solari, D, 2017) |
| "Carnitine is a commonly used antidote for acute intoxication of valproic acid, but is not a therapeutic option for management of chronic adults with adverse effects related to valproic acid." | 1.46 | L-Carnitine supplementation to reverse hyperammonemia in a patient undergoing chronic valproic acid treatment: A case report. ( Fagiolino, P; Guevara, N; Maldonado, C; Silveira, A; Vázquez, M, 2017) |
| "We evaluated the occurrence of seizures in 450 consecutive high-dose BZD dependence patients admitted to our unit from April 2012 to April 2016 for detoxification with low-dose slow subcutaneous infusion of flumazenil associated with routine anticonvulsant prophylaxis." | 1.46 | Low risk of seizures with slow flumazenil infusion and routine anticonvulsant prophylaxis for high-dose benzodiazepine dependence. ( Bongiovanni, LG; Casari, R; Faccini, M; Federico, A; Franchini, E; Lugoboni, F; Morbioli, L; Tamburin, S, 2017) |
| "Using pentylenetetrazole (PTZ)-induced seizures model in mice, the effect of DATS on the anticonvulsant activity of VP was found to be positive, meaning that combination of DATS with VP can confer protection against VP-induced hepatic injurious effects through its antioxidant, antiinflammatory, and antiapoptotic properties without affecting VP antiepileptic activity." | 1.46 | Cytoprotective effects of diallyl trisulfide against valproate-induced hepatotoxicity: new anticonvulsant strategy. ( El-Agamy, DS; Shaaban, AA, 2017) |
| "Decrease of both the frequency of seizures and the incidence of ADRs after TDM implementation suggests that TDM may have given clinicians the opportunity to achieve more optimal patient treatment." | 1.46 | Lamotrigine Drug Interactions in Combination Therapy and the Influence of Therapeutic Drug Monitoring on Clinical Outcomes of Adult Patients. ( Brozmanova, H; Grundmann, M; Kacirova, I; Koristkova, B, 2017) |
| "The intensity of seizures in pretreated mice varied significantly according to circadian stage." | 1.46 | Circadian variation in anticonvulsant activity of valproic acid in mice. ( Aouam, K; Ben-Attia, M; Boughattas, NA; Dridi, I; Khedhaier, WBC; Reinberg, A, 2017) |
| " Serum levels of valproate were estimated using HPLC for pharmacokinetic study." | 1.46 | Pharmacokinetic and pharmacodynamic interaction of hydroalcoholic extract of Ocimum sanctum with valproate. ( Gupta, YK; Joshi, D; Kaleekal, T; Kumar, R; Sarangi, SC, 2017) |
| "Intermittent action tremors in both hands were reported in 31 (41." | 1.46 | The relationship between valproate induced tremors and circulating neurotransmitters: a preliminary study. ( Abdellah, MM; Hamed, SA, 2017) |
| "The median seizure stage, latency onset of first stage 4/5 seizures, and incidence of convulsing animals were recorded." | 1.46 | Octreotide ameliorates inflammation and apoptosis in acute and kindled murine PTZ paradigms. ( Al-Shorbagy, MY; Nassar, NN, 2017) |
| "The number of seizure-free patients in the last 4 weeks was overall CBZ/VPA/LTG/LEV=60%/79%/67%/67%, for generalized epilepsy was CBZ/VPA/LTG/LEV=67%/89%/65%/94%, and for localization-related epilepsy was CBZ/VPA/LTG/LEV=59%/71%/67%/57%." | 1.46 | Efficacy and tolerability of anti-epileptic drugs-an internet study. ( Baker, G; Wieshmann, UC, 2017) |
| " In another independent set of experiments, similar results of drug combination responses were also found." | 1.46 | Anti-Epileptic Drug Combination Efficacy in an In Vitro Seizure Model - Phenytoin and Valproate, Lamotrigine and Valproate. ( French, CR; O'Brien, TJ; Taing, KD; Williams, DA, 2017) |
| "The 6-Hz-induced seizures were accompanied by reduced brain 5-HT, DA, NE, histamine, GABA, and enhanced glutamate levels." | 1.46 | Parachlorophenylalanine-induced 5-HT depletion alters behavioral and brain neurotransmitters levels in 6-Hz psychomotor seizure model in mice. ( Jahan, K; Pillai, KK; Vohora, D, 2017) |
| "Adequate control of seizures remains an unmet need in epilepsy." | 1.43 | Anticonvulsant activity, crystal structures, and preliminary safety evaluation of N-trans-cinnamoyl derivatives of selected (un)modified aminoalkanols. ( Gunia-Krzyżak, A; Koczurkiewicz, P; Marona, H; Nitek, W; Pękala, E; Szkaradek, N; Słoczyńska, K; Waszkielewicz, AM; Żelaszczyk, D; Żesławska, E, 2016) |
| "Epilepsy is a kind of neurogenic diseases with high prevalence and characterized by seizure, brain paradoxical discharge and convulsion in spontaneous, transient, recurrent and uncontrolled manner." | 1.43 | [Establish and use of an epilepsy model in larval zebrafish]. ( Song, DQ; Tang, S; Zhang, JP; Zheng, YM, 2016) |
| "Antiepileptic prophylaxis reduces early seizures, but their use beyond 1 week does not prevent the development of post-traumatic epilepsy." | 1.43 | Antiepileptic prophylaxis following severe traumatic brain injury within a military cohort. ( Craner, M; Cranley, MR; McGilloway, E, 2016) |
| "A treatment with valproic acid was started, obtaining control of the neurological disease." | 1.43 | Recurrent seizures during acute acquired toxoplasmosis in an immunocompetent traveller returning from Africa. ( Bassetti, M; Beltrame, A; Buonfrate, D; Crichiutti, G; Meroni, V; Venturini, S, 2016) |
| "Valproic acid is a versatile antiepileptic drug that is often used in the acute care setting." | 1.43 | Pharmacokinetics and Clinical Utility of Valproic Acid Administered via Continuous Infusion. ( Albuja, AC; Baumann, RJ; Bensalem-Owen, M; Cook, AM; Kapoor, S; Mathias, S; Stewart, AM; Zafar, MS, 2016) |
| "Electroconvulsions were evoked in Albino Swiss mice by a current delivered via ear-clip electrodes." | 1.43 | The effects of cimetidine chronic treatment on conventional antiepileptic drugs in mice. ( Barczyński, B; Czuczwar, SJ; Świąder, K; Świąder, MJ; Tomaszewski, M, 2016) |
| "Recently, the use of acute seizure tests in epileptic rats or mice has been proposed as a novel strategy for evaluating novel AEDs for increased antiseizure efficacy." | 1.43 | Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures. ( Löscher, W; Töllner, K; Twele, F, 2016) |
| "The risk ratio for seizure increase on hormonal (18." | 1.43 | Differential impact of contraceptive methods on seizures varies by antiepileptic drug category: Findings of the Epilepsy Birth Control Registry. ( Cahill, KE; Fowler, KM; Hauser, WA; Herzog, AG; Mandle, HB, 2016) |
| "Generalized tonic-clonic seizures (GTCS) were found in 150/156 patients." | 1.43 | Electroclinical aspects and therapy of Han patients with juvenile myoclonic epilepsy in northern China. ( Bai, J; Chen, BB; Dang, JX; Deng, YC; Jia, FY; Jia, SS; Jiang, Z; Jin, L; Liu, YH; Wang, B; Wang, CT; Wang, D; Wang, JX; Wang, L; Wang, TC; Zhang, L; Zhang, WJ; Zhao, G, 2016) |
| "Response to AED and change in seizure frequency/pattern on follow-up were noted." | 1.43 | Epilepsy with myoclonic absences: Electroclinical characteristics in a distinctive pediatric epilepsy phenotype. ( Jagtap, S; Karkare, K; Menon, RN; Radhakrishnan, A; Soni, H; Zanzmera, P, 2016) |
| " Haematological toxicity is a limiting side effect of both, first line radio-chemotherapy with temozolomide (TMZ) and co-medication with antiepileptic drugs." | 1.42 | Haematological toxicity of Valproic acid compared to Levetiracetam in patients with glioblastoma multiforme undergoing concomitant radio-chemotherapy: a retrospective cohort study. ( Geroldinger, A; Gleiss, A; Grisold, W; Marosi, C; Moser, W; Oberndorfer, S; Sax, C; Sherif, C; Tinchon, A, 2015) |
| "In a first step, we examined anti-seizure effects of 6 AEDs on spontaneous recurrent focal electrographic seizures and secondarily generalized convulsive seizures in epileptic mice, showing that the focal nonconvulsive seizures were resistant to carbamazepine and phenytoin, whereas valproate and levetiracetam exerted moderate and phenobarbital and diazepam marked anti-seizure effects." | 1.42 | Inter-individual variation in the effect of antiepileptic drugs in the intrahippocampal kainate model of mesial temporal lobe epilepsy in mice. ( Bankstahl, M; Klein, S; Löscher, W, 2015) |
| "A relationship between sleep and seizures is well-described in both humans and rodent animal models; however, the mechanism underlying this relationship is unknown." | 1.42 | A new model to study sleep deprivation-induced seizure. ( Leahy, A; Lucey, BP; Rosas, R; Shaw, PJ, 2015) |
| "In addition, the effect on seizure count was compared with that of various AED regimen and the vagus nerve stimulation (VNS)." | 1.42 | Efficacy and tolerability of the ketogenic diet in Dravet syndrome - Comparison with various standard antiepileptic drug regimen. ( Benninger, F; Dressler, A; Feucht, M; Grassl, R; Gröppel, G; Mühlebner, A; Reiter-Fink, E; Reithofer, E; Trimmel-Schwahofer, P, 2015) |
| "Valproic acid treated animals were treated from 5 days preceding behavioral testing in the Morris water maze at a clinically relevant concentration." | 1.42 | Standard dose valproic acid does not cause additional cognitive impact in a rodent model of intractable epilepsy. ( Jellett, AP; Jenks, K; Lucas, M; Scott, RC, 2015) |
| "The boy is currently seizure-free under valproic acid, after twelve months of follow-up." | 1.42 | A child with ictal vocalizations and generalized epilepsy. ( Heritier Barras, AC; Korff, CM; Kurian, M, 2015) |
| "Treatment-resistant seizures affect about a third of patients suffering from epilepsy." | 1.42 | Cross-species pharmacological characterization of the allylglycine seizure model in mice and larval zebrafish. ( Afrikanova, T; Buenafe, OE; Crawford, AD; De Prins, A; de Witte, PA; Esguerra, CV; Kaminski, RM; Langlois, M; Leclercq, K; Rospo, CC; Smolders, I; Van Eeckhaut, A, 2015) |
| "Tonic hind limb extension (seizure activity) was evoked in adult male albino Swiss mice by a current (25 mA, 500 V, 50 Hz, 0." | 1.42 | Effect of xanthotoxin (8-methoxypsoralen) on the anticonvulsant activity of classical antiepileptic drugs against maximal electroshock-induced seizures in mice. ( Florek-Luszczki, M; Glensk, M; Glowniak, K; Luszczki, JJ; Pyrka, D; Skalicka-Wozniak, K; Zagaja, M, 2015) |
| "Adult patients with focal epilepsy, who were prescribed with carbamazepine (CBZ), valproate (VPA), lamotrigine (LTG), topiramate (TPM), or oxcarbazepine (OXC) as monotherapy, during the period from January 2004 to June 2012 registered in Wenzhou Epilepsy Follow Up Registry Database (WEFURD), were included in the study." | 1.42 | Comparative Long-Term Effectiveness of a Monotherapy with Five Antiepileptic Drugs for Focal Epilepsy in Adult Patients: A Prospective Cohort Study. ( Bao, YX; Fan, TT; He, RQ; Xu, HQ; Zeng, QY; Zheng, RY; Zhu, P, 2015) |
| "Recurrent seizures requiring either emergency room (ER) visits or hospitalization were used to measure the efficacy of seizure control." | 1.42 | Efficacy of phenytoin, valproic acid, carbamazepine and new antiepileptic drugs on control of late-onset post-stroke epilepsy in Taiwan. ( Chan, L; Chi, NF; Chien, LN; Chiou, HY; Hu, CJ; Huang, YH; Kuan, YC, 2015) |
| "Despite former publications no clear seizures could be reproduced but it was possible to establish focal EPs, which proved to be a reliable marker for epileptic activity." | 1.42 | Reduction of epileptiform activity through local valproate-implants in a rat neocortical epilepsy model. ( Altenmüller, DM; Feuerstein, TJ; Freiman, TM; Hebel, JM; Herrmann, LS; Rassner, MP; Volz, S, 2015) |
| "Multiple generalized seizures occurred in all homozygous mice around three weeks after birth." | 1.42 | Epileptogenesis and epileptic maturation in phosphorylation site-specific SNAP-25 mutant mice. ( Kataoka, M; Miyaoka, H; Otsuka, S; Saito, M; Suzuki, E; Takahashi, M; Watanabe, S; Yamamori, S, 2015) |
| "Valproic acid (VPA) has been widely used for decades to treat epilepsy; however, its mechanism of action remains poorly understood." | 1.42 | M-current preservation contributes to anticonvulsant effects of valproic acid. ( Greene, DL; Hoshi, N; Kang, S; Kay, HY; Kosenko, A, 2015) |
| "VPA) as first-line treatment of status epilepticus (SE) and seizure clusters in selected patient populations." | 1.40 | Clinical experience with intravenous valproate as first-line treatment of status epilepticus and seizure clusters in selected populations. ( Casciato, S; Di Bonaventura, C; Fanella, M; Fattouch, J; Giallonardo, AT; Gregori, B; Lapenta, L; Manfredi, M; Morano, A; Vanacore, N; Vaudano, AE, 2014) |
| "The treatment profile for epilepsy, seizure control, and maternal and neonatal outcomes in both groups were compared using Chi-square test or Fisher's exact test and Mann-Whitney U test." | 1.40 | Impact of planning of pregnancy in women with epilepsy on seizure control during pregnancy and on maternal and neonatal outcomes. ( Abe, K; Hamada, H; Minakami, H; Obata-Yasuoka, M; Yamada, T; Yoshikawa, H, 2014) |
| "Fifty-four patients were included, with juvenile myoclonic epilepsy (JME) in 23 (42." | 1.40 | Low-dose sodium valproate in the treatment of idiopathic generalized epilepsies. ( Aiguabella, M; Falip, M; Juvany, R; Leiva, E; Miró, J; Salas-Puig, J; Santurino, M; Veciana, M, 2014) |
| "The seizures were easily controlled with valproate and clobazam." | 1.40 | Neck myoclonia with absence seizures in an Indian girl. ( Aneja, S; Jain, P; Sharma, S, 2014) |
| " The data collected included epilepsy type, seizure frequency, concomitant anti-epileptic drugs, dosage of LTG and LTG serum levels." | 1.40 | [Clinical efficacy and pharmacokinetics of lamotrigine for childhood-onset intractable epilepsy]. ( Arakawa, C; Endo, A; Fuchigami, T; Fujita, Y; Imai, Y; Ishii, W; Kohira, R; Momoki, E; Mugishima, H, 2014) |
| "Further, the effect of raloxifene on seizures and on the antiepileptic efficacy of PHT and SVP was investigated." | 1.40 | Raloxifene preserves phenytoin and sodium valproate induced bone loss by modulating serum estradiol and TGF-β3 content in bone of female mice. ( Anwar, MJ; Radhakrishna, KV; Sharma, A; Vohora, D, 2014) |
| "Mixed connective tissue disorder (MCTD) with predominant polymyositis and neuropsychiatric manifestations was diagnosed as the patient had anti-RNP positive with significantly raised muscle enzymes." | 1.40 | Depression and seizures as the main neuropsychiatric manifestation of mixed connective tissue disorder. ( Kiani, IG; Qureshi, SH; Shah, F, 2014) |
| "Oral treatment of carbamazepine was started but her seizures were not controlled." | 1.40 | Serial EEG study in a girl with Landau-Kleffner syndrome associated with continuous spikes and waves during slow sleep. ( Arisaka, O; Imataka, G, 2014) |
| " The combined oral chronic administration of phenylephrine in threshold, noneffective alone dose of 0." | 1.40 | [Stimulation of gastric mucosa afferents by phenylephrine potentiates anticonvulsive and eliminates sedative action of sodium valproate in the pentylenetetrazol kindling model in rats]. ( Gmiro, VE; Serdiuk, SE; Veselkina, OS, 2014) |
| "Partial epilepsy is the most common type of epilepsy in CdLS patients." | 1.39 | Epilepsy in patients with Cornelia de Lange syndrome: a clinical series. ( Agostinelli, S; Capovilla, G; Chiarelli, F; Coppola, G; Curatolo, P; Foiadelli, T; Grosso, S; Parisi, P; Prezioso, G; Romeo, A; Savasta, S; Spalice, A; Striano, P; Verrotti, A, 2013) |
| "Malignant migrating partial seizures in infancy (MMPSI) or Coppola-Dulac syndrome is a rare epilepsy syndrome with the onset in the first 6 months of life, characterized by multiple continuous electroencephalographic and electroclinical focal ictal patterns due to the involvement of different independent areas of both hemispheres with the arrest of psychomotor development." | 1.39 | [The syndrome of malignant migrating partial seizures in infancy or Coppola-Dulac syndrome (19 cases)]. ( Kholin, AA, 2013) |
| "The incidence of seizures, their expression pattern and their latencies were registered and the severity was expressed by means of a five-point scale." | 1.39 | Derivatives of valproic acid are active against pentetrazol-induced seizures in immature rats. ( Bialer, M; Hen, N; Kubová, H; Mareš, P; Yagen, B, 2013) |
| "The mean and median ages at seizure onset were 16 and 18 months, respectively (range 3-40 months)." | 1.39 | Myoclonic epilepsy in infancy: an electroclinical study and long-term follow-up of 38 patients. ( Caraballo, RH; Flesler, S; Fortini, S; Lopez Avaria, MF; Pasteris, MC; Vilte, C, 2013) |
| "This retrospective study compared the seizure outcomes, side effects and durability of levetiracetam with valproic acid after a craniotomy for supratentorial brain tumors." | 1.39 | Levetiracetam compared with valproic acid for the prevention of postoperative seizures after supratentorial tumor surgery: a retrospective chart review. ( Bae, SH; Han, JH; Kim, CY; Kim, T; Kim, YH; Lee, YJ; Yun, CH, 2013) |
| "Dravet syndrome is a catastrophic pediatric epilepsy with severe intellectual disability, impaired social development and persistent drug-resistant seizures." | 1.39 | Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment. ( Baraban, SC; Dinday, MT; Hortopan, GA, 2013) |
| "Mutations in SHANK3 and large duplications of the region spanning SHANK3 both cause a spectrum of neuropsychiatric disorders, indicating that proper SHANK3 dosage is critical for normal brain function." | 1.39 | SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties. ( Breman, AM; Chen, H; Cheung, SW; Han, K; Hao, S; Holder, JL; Kang, H; Lu, H; Lu, HC; Patel, A; Schaaf, CP; Sun, H; Tang, J; Wu, Z; Yu, P; Zoghbi, HY, 2013) |
| "Onset of absence seizures in the first year of life is very rare." | 1.39 | Early-onset absence epilepsy aggravated by valproic acid: a video-EEG report. ( Belcastro, V; Caraballo, RH; Romeo, A; Striano, P, 2013) |
| "Among those with Idiopathic Generalized Epilepsy (46%), generalized tonic clonic seizure was encountered in 74% and absence seizure was observed in 13%." | 1.39 | Antiepileptic drug utilization in Bangladesh: experience from Dhaka Medical College Hospital. ( Chowdhury, AH; Chowdhury, RN; Ghose, SK; Habib, M; Haque, B; Hasan, AT; Hoque, A; Khan, SU; Mohammad, QD; Mondal, BA; Rahman, KM, 2013) |
| "Peroral chronic administration the standard antiepileptic drug sodium valproate in a dose of 200 mg/kg eliminates development of generalized clonic-tonic pentylenetetrazol kindling seizures in 100% of rats, but only in 57% of rats this treatment prevents clonic kindling seizures." | 1.39 | [Combined blockade of AMPA- and NMDA-receptors has maximum effect to eliminate development of pentylenetetrazole-induced kindling in rats]. ( Gmiro, VE; Serdiuk, SE; Veselkina, OS, 2013) |
| "Seizures were treated with sodium valproate (n = 11), phenobarbital (n = 3), diazepam (n = 2), lamotrigine (n = 1), and carbamazepine (n = 1)." | 1.39 | Prevalence of seizures in children infected with human immunodeficiency virus. ( Eley, B; Petersen, R; Samia, P; Walker, KG; Wilmshurst, JM, 2013) |
| "Vagus nerve stimulation prevents seizures by continuously activating noradrenergic projections from the brainstem to the cortex." | 1.39 | Closed-loop neural stimulation for pentylenetetrazole-induced seizures in zebrafish. ( Beattie, CE; Hall, CW; Pineda, R, 2013) |
| "The activity of these compounds on seizure control is independent of histone deacetylase inhibitory activity (associated with the teratogenicity of VPA), and does not correlate with liver cell toxicity." | 1.39 | Seizure control by ketogenic diet-associated medium chain fatty acids. ( Chang, P; Chen, PE; Plant, N; Terbach, N; Walker, MC; Williams, RS, 2013) |
| "Focal seizures were more frequent during drowsiness and sleep." | 1.39 | Epilepsy in Mowat-Wilson syndrome: delineation of the electroclinical phenotype. ( Bianchi, P; Bonetti, S; Boni, A; Buoni, S; Cecconi, I; Cerruti Mainardi, P; Cordelli, DM; Della Giustina, E; Doz, M; Epifanio, R; Faravelli, F; Ferrari, AR; Franzoni, E; Garavelli, L; Gelmini, C; Giordano, L; Grasso, M; Grioni, D; Grosso, S; Guerra, A; Licata, F; Malbora, B; Mammi, I; Mari, F; Mazzanti, L; Mostardini, R; Pantaleoni, C; Pellicciari, A; Poch-Olivé, ML; Rivieri, F; Rosato, S; Savasta, S; Seri, M; Simonte, G; Sorge, G; Tarani, L; Terazzi, E; Wischmeijer, A; Zanotta, N; Zollino, M, 2013) |
| "Nonketotic hyperglycinemia (NKH), or glycine encephalopathy, is an autosomal recessive disorder caused by a defect in the glycine cleavage enzyme system." | 1.38 | Paradoxical increase in seizure frequency with valproate in nonketotic hyperglycinemia. ( Aida, N; Iai, M; Kure, S; Osaka, H; Shimbo, H; Tsuji, M; Tsuyusaki, Y; Wada, T; Yamashita, S, 2012) |
| " Additionally, the effects of acute and chronic administration of both statins on the adverse effect potential of three antiepileptic drugs were assessed in the chimney test (motor performance) and passive avoidance task (long-term memory)." | 1.38 | The interactions of atorvastatin and fluvastatin with carbamazepine, phenytoin and valproate in the mouse maximal electroshock seizure model. ( Czuczwar, SJ; Luszczki, JJ; Stepien, KM; Tomaszewski, M, 2012) |
| "After induction of seizure by PTZ, initiation time of myoclonic seizures (ITMS), initiation time of tonic-clonic seizures (ITTS), seizures duration (SD) and mortality rate (MR) were recorded for 30 min." | 1.38 | The antiepileptic effect of sodium valproate during different phases of the estrous cycle in PTZ-induced seizures in rats. ( Azimi, M; Habibian, S; Kaboutari, J; Karimi, B; Shaker, M; Zendehdel, M, 2012) |
| "Epileptic myoclonus is generally treated by valproate monotherapy, and this therapy has confirmed efficacy." | 1.38 | Stepwise synchronization through the corpus callosum is one cause of myoclonic jerks. ( Arai, H; Iimura, Y; Nakajima, M; Sugano, H, 2012) |
| "In this context, the focal seizures probably result from a diffuse decrease in the seizure threshold (caused by a generalized excitatory rebound), which may trigger focal seizures arising from cortical regions with higher intrinsic epileptogenicity." | 1.38 | Focal nonconvulsive seizures during detoxification for benzodiazepine abuse. ( Albiero, A; Bongiovanni, LG; Brigo, F; Casari, R; Faccini, M; Fiaschi, A; Lugoboni, F; Quaglio, G; Storti, M, 2012) |
| "Phenytoin was used in 56 patients (22%) with the majority (n= 43) receiving intravenous phenytoin." | 1.38 | Seizure management at Auckland City Hospital Emergency Department between July and December 2009: time for a change? ( Bergin, P; Jones, P; Rosemergy, I; Walker, E, 2012) |
| "Although nephrocalcinosis is not a common feature in patients with proximal tubulopathy, the patient presented also with this condition, and the concomitant use of another anticonvulsant might have potentiated this condition." | 1.38 | Anticonvulsant-induced rickets and nephrocalcinosis. ( Lau, KK; Papneja, K, 2012) |
| "The results show enhancement of seizure severity with significant reduction in GABA levels upon PTX treatment that were reversed by its combination with sodium valproate." | 1.38 | Combination of valproate and paroxetine in mice exposed to picrotoxin. ( Kamal, SM, 2012) |
| " This study summarizes 6 cases of drug-drug interactions between VPA and carbapenem antibiotics." | 1.38 | Reduced valproic acid serum concentrations due to drug interactions with carbapenem antibiotics: overview of 6 cases. ( Cho, JY; Han, HK; Jang, IJ; Kim, TE; Lim, KS; Park, MK; Shin, KH; Shin, SG; Yi, SJ; Yu, KS, 2012) |
| "Seizures were controlled in 1 case, suspiciously controlled in 1 case, decreased in frequency in 4 cases and were still frequent in 1 case." | 1.38 | [Clinical and electroencephalographic characteristics of Jeavons syndrome]. ( Liu, XY; Qin, J; Yang, ZX; Zhang, YH, 2012) |
| "It also proved protection in focal seizures (electric kindling, rats, ip) and it raises seizure threshold." | 1.37 | Synthesis and anticonvulsant activity of trans- and cis-2-(2,6-dimethylphenoxy)-N-(2- or 4-hydroxycyclohexyl)acetamides and their amine analogs. ( Marona, H; Pękala, E; Szneler, E; Walczak, M; Waszkielewicz, AM, 2011) |
| " Pharmacokinetic parameters are necessary to predict the optimum therapeutic level after administration." | 1.37 | Pharmacokinetics and clinical application of intravenous valproate in Thai epileptic children. ( Bhudhisawadi, K; Chulavatnatol, S; Kaojareon, S; Vaewpanich, J; Visudtibhan, A, 2011) |
| "For unclassified epileptic seizures, no significant differences were found among the three AEDs." | 1.37 | Retrospective analysis of the effectiveness of first-line antiepileptic drugs for generalized onset and unclassified epileptic seizures in Chinese children. ( Ding, CH; Ding, YX; Fang, F; Ma, MS; Meng, LL; Wang, Y; Zou, LP, 2011) |
| "Recurrent seizures may occur in up to 11% of HIV positive patients." | 1.37 | Sodium valproate and highly active antiretroviral therapy in HIV positive patients who develop new onset seizures. ( Bhigjee, AI; Moodley, P; Parboosing, R; Yacoob, Y, 2011) |
| "Fourteen patients developed seizures during that period and 25 did not." | 1.37 | Risk factors for late-onset seizures related to cerebral contusions in adults with a moderate traumatic brain injury. ( De Reuck, J, 2011) |
| "On VPA 1000 mg/d, the seizure frequency decreased significantly." | 1.37 | Valproate treatment after liver transplant in a patient with Lennox-Gastaut syndrome. ( Crespel, A; Gelisse, P; Genton, P; Pageaux, GP; Velizarova, R, 2011) |
| "Valproic acid (VPA) has been reported to cause cognitive decline and parkinsonism that are reversed with cessation of medication." | 1.37 | Reversible dementia and gait disturbance after prolonged use of valproic acid. ( Evans, MD; Shinar, R; Yaari, R, 2011) |
| "Subacute encephalopathy with seizures in chronic alcoholism (SESA) was first described in 1981 by Niedermeyer who reported alcoholic patients presenting with confusion, seizures and focal neurological deficits and is quite distinct from patients presenting with typical alcohol withdrawal seizures." | 1.37 | Subacute encephalopathy and seizures in alcoholics (SESA) presenting with non-convulsive status epilepticus. ( LaRoche, SM; Shivdat-Nanhoe, R, 2011) |
| "Valproic acid (VPA) is a first-line antiepileptic drug for therapy of patients with IGE." | 1.37 | Valproate reduces spontaneous generalized spikes and waves but not photoparoxysmal reactions in patients with idiopathic generalized epilepsies. ( Boor, R; Ettle, E; Muhle, H; Siniatchkin, M; Stephani, U, 2011) |
| "He experienced convulsions from day 4 and was administered anticonvulsants." | 1.37 | [Prolonged convulsion after intoxication of alachlor herbicide (Lasso): a case report]. ( Hagioka, S; Maeyama, H; Morimoto, N; Nagae, M; Naito, H; Okada, D; Okahara, S, 2011) |
| "After treatment with levetiracetam, seizures recurred and intravenous loading with valproic acid was administered, but resulted in a rapid increase in international normalized ratio (INR) to 7." | 1.37 | Valproic acid and warfarin: an underrecognized drug interaction. ( Giraldo, EA; Wijdicks, EF; Yoon, HW, 2011) |
| " Plasma concentrations (pc), interactions between drugs in the ICU context, adverse effects and seizure occurrences were observed and recorded." | 1.37 | Levetiracetam compared to valproic acid: plasma concentration levels, adverse effects and interactions in aneurysmal subarachnoid hemorrhage. ( Bjeljac, M; Keller, E; Mink, S; Muroi, C; Seule, M, 2011) |
| "Some authors suggest that most impact seizures are non-epileptic in origin and hence coined the term "concussive convulsions" for benign impact seizures." | 1.37 | [Concussive convulsions: seizure or no seizure?]. ( Burghaus, L; Elger, CE; Fink, GR; Nass, RD, 2011) |
| "The less VPA was able to raise seizure threshold, the lower was the VPA-induced reduction of SNr firing rate and the VPA-induced regularity of SNr firing." | 1.37 | The anticonvulsant response to valproate in kindled rats is correlated with its effect on neuronal firing in the substantia nigra pars reticulata: a new mechanism of pharmacoresistance. ( Gernert, M; Löscher, W; Töllner, K; Wolf, S, 2011) |
| "Hyperammonemia was detected in 8 patients treated with valproic acid." | 1.36 | Serum biotinidase activity in children treated with valproic acid and carbamazepine. ( Castiñeiras-Ramos, DE; Castro-Gago, M; Díaz-Mayo, I; Eirís-Puñal, J; Gómez-Lado, C, 2010) |
| " VCU was mainly eliminated by metabolism with a half-life of 2 h." | 1.36 | Evaluation of stereoselective anticonvulsant, teratogenic, and pharmacokinetic profile of valnoctylurea (capuride): a chiral stereoisomer of valproic acid urea derivative. ( Bialer, M; Finnell, RH; Schurig, V; Shimshoni, JA; Wlodarczyk, B; Yagen, B, 2010) |
| "Clonic seizures were rare in NMDA-treated P25 rats, but valproate pretreatment increased their incidence significantly." | 1.36 | Vigabatrin but not valproate prevents development of age-specific flexion seizures induced by N-methyl-D-aspartate (NMDA) in immature rats. ( Kubová, H; Mares, P, 2010) |
| "Whilst post-ictal psychosis is rarely reported prior to the age of 16, NPC in adolescents and adults is particularly psychotogenic and may increase the risk for post-ictal psychosis in the pediatric population." | 1.36 | Post-ictal psychosis in adolescent Niemann-Pick disease type C. ( Adams, S; Fietz, M; Kornberg, A; Velakoulis, D; Walterfang, M, 2010) |
| "Levetiracetam (LEV) is a unique antiepileptic drug that preferentially interacts with synaptic vesicle protein 2A (SV2A)." | 1.36 | Antiepileptogenic and anticonvulsive actions of levetiracetam in a pentylenetetrazole kindling model. ( Ishihara, S; Ohno, Y; Sasa, M; Serikawa, T; Terada, R, 2010) |
| "PTZ provoked clonic convulsions, reduced GABA content, deranged brain redox status, and elevated nitric oxide (NO)." | 1.36 | Magnesium supplementation enhances the anticonvulsant potential of valproate in pentylenetetrazol-treated rats. ( Abdallah, DM; Abdel-Aziz, MT; Arafa, NM; Safar, MM, 2010) |
| "Clonazepam was stopped." | 1.36 | Late-onset nocturnal intractable seizure during sleep: what is the origin? ( Liesiene, V; Miliauskas, S; Sakalauskas, R; Zemaitis, M, 2010) |
| "The aim of this study was to characterize the anticonvulsant effects of stiripentol (STP) in combination with clobazam [CLB], and valproate [VPA]) in the mouse maximal electroshock (MES)-induced seizure model using the type I isobolographic analysis for parallel and non-parallel dose-response relationship curves (DRRCs)." | 1.36 | Interactions of stiripentol with clobazam and valproate in the mouse maximal electroshock-induced seizure model. ( Czuczwar, SJ; Luszczki, JJ; Patsalos, PN; Ratnaraj, N; Trojnar, MK, 2010) |
| "Goodpasture's syndrome is a rare autoimmune disorder characterized by rapidly progressive glomerulonephritis (RPGN) and alveolar hemorrhage in the presence of antiglomerular basement membrane (anti-GBM) antibodies." | 1.36 | [Goodpasture's syndrome with neurologic involvement and negative ANCA]. ( Cobo, M; Delgado, P; González-Posada, JM; Hernández, D; Marrero, D; Pérez-Suárez, G; Rodríguez, R, 2010) |
| "Intravenous forms of valproate control seizures in a more rapid and efficacious pattern than oral forms." | 1.36 | Intravenous valproate for seizures in 137 Taiwanese children - valproate naive and non-naive. ( Chang, YC; Chou, ML; Hsieh, MY; Hung, PC; Lin, JJ; Wang, HS, 2010) |
| "Sex, age, familial history, type of seizures and AED treatment were noted and EEG monitoring, MRI and CT scanning, and developmental and psychomotor evolution were investigated." | 1.36 | Benign infantile focal epilepsy with midline spikes and waves during sleep: a new epileptic syndrome or a variant of benign focal epilepsy? ( Caraballo, R; Cersósimo, R; Flesler, S; Sakr, D, 2010) |
| "Epilepsy was diagnosed in 37% (375/1014) of the study participants." | 1.36 | Correlation between EEG abnormalities and symptoms of autism spectrum disorder (ASD). ( Yasuhara, A, 2010) |
| "Eating-induced seizures are an uncommon presentation of reflex epilepsy, a condition characterized by seizures provoked by specific stimuli." | 1.36 | Unilateral opercular lesion and eating-induced seizures. ( Friedman, DE; Kung, DH; Manyam, SC; Newmark, ME; Rhodes, LB, 2010) |
| "The aggravation of habitual seizures and interictal discharges indicate ENM." | 1.35 | A study on epileptic negative myoclonus in atypical benign partial epilepsy of childhood. ( Bao, X; Chang, X; Liu, X; Qin, J; Wang, S; Wu, Y; Xiong, H; Yang, Z; Zhang, Y, 2009) |
| " This case report indicates that even non-chronic MDMA use may cause subacute toxic encephalopathy in which the clinical evolution is paralleled by neuroimaging changes in specific cerebral areas." | 1.35 | Hippocampal remodelling after MDMA neurotoxicity: a single case study. ( Amistà, P; Battaglia, M; Bertagnoni, GE; Carollo, C; Costanzo, R; Lupi, A; Martinuzzi, A; Nifosì, F; Perini, G; Toffanin, T; Vestri, A, 2009) |
| "We report a case of familial hemiplegic migraine with prolonged aura where multimodality imaging showed hemispheric cytotoxic edema along with evidence of hypometabolism in the affected hemisphere while there was no evidence of hypoperfusion of the affected hemisphere demonstrating that neuronal depression is a more plausible explanation in its pathogenesis." | 1.35 | Familial hemiplegic migraine with prolonged aura and multimodality imaging: a case report. ( Kumar, G; Maytal, J; Topper, L, 2009) |
| "Nicotine pretreatment reversed the anti-lipid peroxidative action of sodium valproate in the PTZ-induced seizure model in mice." | 1.35 | Dose-finding study with nicotine as a proconvulsant agent in PTZ-induced seizure model in mice. ( Chakrabarti, A; Medhi, B; Sahai, AK; Sood, N, 2008) |
| "(2007) Seizure suppression by top1 mutations in Drosophila." | 1.35 | DNA topoisomerase I inhibitors ameliorate seizure-like behaviors and paralysis in a Drosophila model of epilepsy. ( Hormozi, L; Parker, L; Song, J; Tanouye, MA, 2008) |
| " The isobolographic analysis for parallel and nonparallel dose-response effects was used in the mouse maximal electroshock seizure (MES) model for evaluation of pharmacodynamic interaction." | 1.35 | Isobolographic characterization of interactions of retigabine with carbamazepine, lamotrigine, and valproate in the mouse maximal electroshock-induced seizure model. ( Czuczwar, SJ; Luszczki, JJ; Raszewski, G; Wu, JZ, 2009) |
| "Efficacy of seizure control was considered satisfactory if there was a reduction in seizures>50% or total control." | 1.35 | Association of lamotrigine and valproate in refractory epilepsies of children and adolescents. ( Antoniuk, SA; Bruck, I; Grisotto, KP; Santos, LH, 2008) |
| "Valproic acid (VPA) treatment and paraoxonase1/arylesterase (PON1/Aryl) activities are related to the production of free radicals." | 1.35 | Early effects of sodium valproate monotherapy on serum paraoxonase/arylesterase activities. ( Bartzeliotou, A; Fytou-Pallikari, A; Giannoulia-Karantana, A; Karikas, GA; Papaevangelou, V; Papassotiriou, I; Regoutas, S; Schulpis, KH; Thanopoulou, C, 2009) |
| "To characterize the interaction between tiagabine (TGB) and valproate (VPA)--two antiepileptic drugs in the mouse pentylenetetrazole (PTZ)-induced clonic seizure model, type I isobolographic analysis for non-parallel dose-response relationship curves (DRRCs) was used." | 1.35 | Interaction of tiagabine with valproate in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis for non-parallel dose-response relationship curves. ( Krzyzanowski, M; Luszczki, JJ; Swiader, MJ, 2009) |
| "The aim of this study was to determine and compare the anticonvulsant and acute adverse (neurotoxic) effects of imperatorin and osthole (two natural coumarin derivatives) with valproate (a classical antiepileptic drug) in the maximal electroshock seizure and chimney tests in mice." | 1.35 | Anticonvulsant and acute neurotoxic effects of imperatorin, osthole and valproate in the maximal electroshock seizure and chimney tests in mice: a comparative study. ( Andres-Mach, M; Cisowski, W; Czuczwar, SJ; Glensk, M; Glowniak, K; Luszczki, JJ; Wojda, E, 2009) |
| "Although seizures in brain tumor patients are common, the knowledge on optimal anti-seizure therapy in this patient group is limited." | 1.35 | Efficacy of anti-epileptic drugs in patients with gliomas and seizures. ( Rijsman, RM; Taphoorn, MJ; van Breemen, MS; Vecht, CJ; Walchenbach, R; Zwinkels, H, 2009) |
| "A total of 344 patients became seizure-free with the first prescribed antiepileptic drug." | 1.35 | Effectiveness of the first antiepileptic drug in the treatment of pediatric epilepsy. ( Ding, CH; Ding, YX; Fang, F; Ma, MS; Ying, W; Zou, LP, 2009) |
| "The pregnancy was continued and the child is developing well during 16 months of follow-up." | 1.35 | Prenatal diagnosis of cerebral lesions in Tuberous sclerosis complex (TSC). Case report and review of the literature. ( Creemers, JW; Mullaart, RA; Reimer, A; Wortmann, SB, 2008) |
| "The significant proportion of seizure-free cases (27%) on duotherapy is suggesting the usefulness of combination therapy in achieving seizure-freedom in epilepsies refractory to single drug treatment." | 1.35 | Seizure-freedom with combination therapy in localization-related epilepsy. ( Auvinen, A; Keränen, T; Kharazmi, E; Peltola, J; Peltola, M; Raitanen, J, 2008) |
| " It showed a beneficial pharmacokinetic profile in rats, having a high oral bioavailability of 75% and satisfactory values of clearance and volume of distribution." | 1.34 | Anticonvulsant activity, neural tube defect induction, mutagenicity and pharmacokinetics of a new potent antiepileptic drug, N-methoxy-2,2,3,3-tetramethylcyclopropane carboxamide. ( Bialer, M; Finnell, RH; Lamb, JG; Sobol, E; White, HS; Wlodarczyk, BJ; Yagen, B, 2007) |
| "To describe the dose-concentration relationship of a continuous intravenous infusion of valproic acid (VPA) in pediatric patients when a dosing protocol is used." | 1.34 | Clinical utility of a continuous intravenous infusion of valproic acid in pediatric patients. ( Baumann, RJ; Cook, AM; Farzam, F; Kuhn, RJ; Lewis, DA; Taylor, LM, 2007) |
| "This means that seizures do not arise de novo in the seizure focus." | 1.34 | Temporal lobe epilepsy is a disease of faulty neuronal resonators rather than oscillators, and all seizures are provoked, usually by stress. ( Eggers, AE, 2007) |
| "Kainic acid-induced seizures, a rodent model of human temporal lobe epilepsy, strongly induce the proliferation of DG neurogenic progenitor cells and are also associated with long-term cognitive impairment." | 1.34 | Epigenetic modulation of seizure-induced neurogenesis and cognitive decline. ( Clemenson, GD; Gage, FH; Hsieh, J; Jessberger, S; Mathews, E; Mejia, E; Nakashima, K; Ogawa, S; Sinton, CM; Ure, K, 2007) |
| "Ertapenem was discontinued, and his divalproex sodium dosage was increased further." | 1.34 | Acute seizures in a patient receiving divalproex sodium after starting ertapenem therapy. ( Lunde, JL; Nelson, RE; Storandt, HF, 2007) |
| "LTG in some regions of the CNS enhanced seizure-induced IEG expression." | 1.33 | Valproic acid, but not lamotrigine, suppresses seizure-induced c-fos and c-Jun mRNA expression. ( Anderson, GD; Shen, DD; Szot, P; White, SS, 2005) |
| "We have observed acute dystonias in the absence of antipsychotic treatment and in the context of seizure activity (or paroxysmal dyskinetic activity)." | 1.33 | High vulnerability to acute dystonic reactions: a case of antipsychotic exposure and uncontrolled seizure activity. ( Botts, SR; Coffey, GL; de Leon, J, 2005) |
| "Valproic acid (VPA) is a widely used treatment for both epilepsy and bipolar disorders, although its therapeutic mechanism of action is not fully understood." | 1.33 | Reduced anticonvulsant efficacy of valproic acid in dopamine beta-hydroxylase knockout mice. ( Liles, LC; Schank, JR; Weinshenker, D, 2005) |
| " Following valproic acid (VPA, 30 mg/kg), the population spike amplitude and the EPSP slope in response to the stimulus were markedly reduced in the dentate gyri both of SR and of SS gerbils, although this dosage of VPA had no effect in low stimulus currents in SS gerbils." | 1.33 | Valproic acid reduces enhanced vesicular glutamate transporter immunoreactivities in the dentate gyrus of the seizure prone gerbil. ( Choi, SY; Kang, JH; Kang, TC; Kim, DS; Kim, DW; Kim, JE; Kwak, SE; Kwon, OS; Won, MH, 2005) |
| "Maximal electroshock seizures (MES) in albino rats and pentylenetetarazole (PTZ) induced seizures in albino mice were used to study anticonvulsant activity of Vitex-negundo leaf extract." | 1.33 | An experimental evaluation of anticonvulsant activity of Vitex-negundo. ( Gupta, RK; Tandon, VR, 2005) |
| "A diagnosis of generalized NCSE with tonic seizures was made on the basis of the clinical picture and response to barbiturate anaesthetic, although the EEG pattern was not typical of the changes previously described in tonic seizures-tonic status epilepticus." | 1.33 | Prolonged postictal stupor: nonconvulsive status epilepticus, medication effect, or postictal state? ( Chattopadhyay, A; Kuc, S; Langheinrich, TC; Reuber, M, 2005) |
| "Lamotrigine (LTG) was prescribed in 29 patients as add-on therapy." | 1.33 | The use of lamotrigine and other antiepileptic drugs in paediatric patients at a Malaysian hospital. ( Ab Rahman, AF; Ibrahim, MI; Ismail, HI; Seng, TB, 2005) |
| " Linear regression analysis of dose-response relationship between the doses of 2-PMPA and their corresponding threshold values allowed the calculation of threshold increasing dose by 20% (TID20), which was 109." | 1.33 | 2-phosphonomethyl-pentanedioic acid (glutamate carboxypeptidase II inhibitor) increases threshold for electroconvulsions and enhances the antiseizure action of valproate against maximal electroshock-induced seizures in mice. ( Czuczwar, SJ; Luszczki, JJ; Mohamed, M, 2006) |
| "Doripenem and meropenem did not induce convulsions at up to 100 microg/mouse." | 1.33 | Absence of convulsive liability of doripenem, a new carbapenem antibiotic, in comparison with beta-lactam antibiotics. ( Abe, K; Arai, T; Hasebe, N; Horiuchi, M; Kimura, M; Tokumura, M, 2006) |
| "Valproic acid products were the most commonly dispensed type of anticonvulsant." | 1.33 | Anticonvulsant treatment for psychiatric and seizure indications among youths. ( Gardner, JF; Ryu, J; Safer, DJ; Soeken, K; Zito, JM, 2006) |
| "Treatment with valproic acid decreased the complaints." | 1.33 | Autonomic headache with autonomic seizures: a case report. ( Kaleagasi, H; Ozge, A; Yalçin Tasmertek, F, 2006) |
| "In the maximal electroshock-induced seizure test (MES), this compound had ED50 values of 108 mg/kg in rats and 115 mg/kg in mice." | 1.32 | Tetramethylcyclopropyl analogue of a leading antiepileptic drug, valproic acid. Synthesis and evaluation of anticonvulsant activity of its amide derivatives. ( Bialer, M; Sobol, E; Yagen, B, 2004) |
| " Although visual hallucinations have not been reported as an adverse effect of this agent, we describe three patients who experienced complex visual hallucinations and altered mental status after zonisamide treatment was begun or its dosage increased." | 1.32 | Visual hallucinations associated with zonisamide. ( Akman, CI; Goodkin, HP; Riviello, JJ; Rogers, DP, 2003) |
| " administration of individual enantiomers to mice, with (R)-PID having lower clearance and longer half-life than (S)-PID." | 1.32 | Characterization of the anticonvulsant profile and enantioselective pharmacokinetics of the chiral valproylamide propylisopropyl acetamide in rodents. ( Bennett, GD; Bialer, M; Blotnik, S; Finnell, RH; Isoherranen, N; Spiegelstein, O; White, HS; Wilcox, KS; Woodhead, JH; Yagen, B, 2003) |
| "Intravenous VPA loading is safe and effective for treating acute seizure emergencies in children." | 1.32 | Safety and efficacy of intravenous valproate in pediatric status epilepticus and acute repetitive seizures. ( Cunanan, C; Mills, S; Thompson, N; Yu, KT, 2003) |
| " In mice, VTD had five to 10 times lower clearance (CL), and three times longer half-life than I-VTD and DM-VTD, making it a more attractive compound than DM-VTD and I-VTD for further development." | 1.32 | Anticonvulsant activity, teratogenicity and pharmacokinetics of novel valproyltaurinamide derivatives in mice. ( Bialer, M; Finnell, RH; Isoherranen, N; Merriweather, M; Spiegelstein, O; White, HS; Wlodarczyk, B; Woodhead, JH; Yagen, B, 2003) |
| "The epileptic seizures described in this report have not been previously documented in Rett syndrome." | 1.32 | Rett syndrome: a case presenting with atypical seizures. Neurophysiological and clinical aspects. ( Jerez-García, P; Marco-Giner, J; Onsurbe-Ramírez, I; Pardal-Fernández, JM, 2004) |
| "To study the effect of seizures and antiepileptic drugs on prolactin (PRL) secretions." | 1.31 | Effect of seizures and antiepileptic drugs on prolactin secretions. ( Wang, MF, 2002) |
| "Despite the frequency of seizure disorders in the human population, the genetic basis for these defects remains largely unclear." | 1.31 | Anticonvulsant valproate reduces seizure-susceptibility in mutant Drosophila. ( Kuebler, D; Tanouye, M, 2002) |
| "Using an amygdala-kindled seizure paradigm, we evaluated the acute and chronic anticonvulsant effects of lamotrigine (LTG)." | 1.31 | Tolerance to the anticonvulsant effects of lamotrigine on amygdala kindled seizures: cross-tolerance to carbamazepine but not valproate or diazepam. ( Heynen, T; Krupp, E; Li, XL; Post, RM; Weiss, SR, 2000) |
| "Sensitivity to PTZ-induced seizures and lethality was not affected in mice with a history of repeated treatment with ganaxolone, diazepam, or valproate." | 1.31 | Acute and chronic effects of the synthetic neuroactive steroid, ganaxolone, against the convulsive and lethal effects of pentylenetetrazol in seizure-kindled mice: comparison with diazepam and valproate. ( Beekman, M; Carter, RB; Gasior, M; Ungard, JT; Witkin, JM, 2000) |
| "One of the leading causes of hypersomnia is sleep apnea." | 1.31 | Influence of chronic barbiturate administration on sleep apnea after hypersomnia presentation: case study. ( Bishop, J; Takhar, J, 2000) |
| "The loading dosage of intravenous valproate required to achieve a desired serum concentration in neonates is not known." | 1.31 | Intravenous valproate dosing in neonates. ( Alfonso, I; Alvarez, LA; Dunoyer, C; Gilman, J; Papazian, O; Yelin, K, 2000) |
| "Amygdala-kindled seizures were inhibited by conventional antiepileptics, their lowest effective doses were: 20 mg/kg for carbamazepine and phenobarbital, 50 mg/kg for diphenylhydantoin, and 100 mg/kg for valproate magnesium." | 1.31 | Glutamate receptor antagonists differentially affect the protective activity of conventional antiepileptics against amygdala-kindled seizures in rats. ( Borowicz, KK; Czuczwar, SJ; Kleinrok, Z, 2001) |
| " Pharmacodynamic analysis in rats showed that (S)-HP-VPD was 2." | 1.31 | Stereoselective pharmacokinetic analysis and antiepileptic activity of N-2-hydroxypropyl valpromide, a central nervous system--active chiral valproylamide. ( Bialer, M; Blotnik, S; Papo, N; Wasserman, M; Yagen, B, 2001) |
| "Seizures were treated with valproate." | 1.31 | [Cerebral vasculitis as the initial manifestation of systemic lupus erythematosus]. ( Bergner, R; Lowitzsch, K; Niedermaier, N; Wolf, J, 2001) |
| "The interval until convulsion due to picrotoxin was also prolonged by the administration of DMP combined with diazepam and valproic acid (VPA)." | 1.31 | Effect of alkylpyrazine derivatives on the duration of pentobarbital-induced sleep, picrotoxicin-induced convulsion and gamma-aminobutyric acid (GABA) levels in the mouse brain. ( Aoyagi, Y; Ohta, A; Watanabe, Y; Yamada, K, 2001) |
| "In MES seizures significant protection was seen with aspirin 100 mg/kg where as higher dose of aspirin 500 mg/kg was required to elicit maximum protection against PTZ seizures." | 1.31 | Aspirin modulates the anticonvulsant effect of diazepam and sodium valproate in pentylenetetrazole and maximal electroshock induced seizures in mice. ( Gupta, YK; Srivastava, AK, 2001) |
| "To quantify changes in ictal seizure semiology during rapid withdrawal of carbamazepine (CBZ) and valproate (VPA) from a monoregimen in presurgical evaluation." | 1.31 | Influence on ictal seizure semiology of rapid withdrawal of carbamazepine and valproate in monotherapy. ( Hopp, P; Kerling, F; Kirchner, A; Pauli, E; Stefan, H; Wang, Y; Zhou, D, 2002) |
| "Glycine is a small neutral amino acid exhibiting weak anticonvulsant activities in vivo." | 1.30 | N-(benzyloxycarbonyl)glycine esters and amides as new anticonvulsants. ( Geurts, M; Lambert, DM; Poupaert, JH; Scriba, GK, 1998) |
| "One patient had moderate confusion, and the other mild confusion and hypomania." | 1.30 | Combined valproate or carbamazepine and electroconvulsive therapy. ( Baraibar, G; Tohen, M; Zarate, CA, 1997) |
| "Total remission of seizures occurred in 52%." | 1.30 | Long-term outcomes of conventional therapy for infantile spasms. ( Clarke, SL; Griesemer, DA; Holden, KR, 1997) |
| "Seizures are common in patients infected with human immunodeficiency virus (HIV)." | 1.30 | Elevated free phenytoin and free valproic acid concentrations in sera of patients infected with human immunodeficiency virus. ( Dasgupta, A; McLemore, JL, 1998) |
| " For comparison of drug potencies, doses increasing seizure thresholds by 20 or 50% were calculated from dose-response curves." | 1.30 | Anticonvulsant drug effects in the direct cortical ramp-stimulation model in rats: comparison with conventional seizure models. ( Krupp, E; Löscher, W, 1998) |
| "We treated a 31-year-old woman with systemic lupus erythematosus, renal failure with nephrotic syndrome, and a long-standing seizure disorder, who developed severe hyperammonemia with a fatal outcome." | 1.30 | Fatal hyperammonemia in a patient with systemic lupus erythematosus. ( Amano, T; Ichikawa, H; Kawabata, K; Kushiro, M; Makino, H; Nagake, Y; Wada, J, 1998) |
| "In the maximal electroshock seizure threshold test, clobenpropit dose-dependently raised the electroconvulsive threshold for tonic (hindlimb extension) seizures, but a significant increase of about 15% was determined only at the high dose of 40 mg/kg i." | 1.30 | Effect of clobenpropit, a centrally acting histamine H3-receptor antagonist, on electroshock- and pentylenetetrazol-induced seizures in mice. ( Fischer, W; van der Goot, H, 1998) |
| " It is concluded that the synergism may be due to a pharmacodynamic rather than a pharmacokinetic interaction." | 1.30 | Pharmacodynamic interaction between phenytoin and sodium valproate changes seizure thresholds and pattern. ( Danhof, M; Della Paschoa, OE; Hamstra, R; Kruk, MR; Voskuyl, RA, 1998) |
| "This report characterizes seizures in a novel genetic model of developmental epilepsy, the Flathead (FH) rat." | 1.30 | Characterization of seizures in the flathead rat: a new genetic model of epilepsy in early postnatal development. ( D'Mello, SR; LoTurco, JJ; Rattan, S; Sarkisian, MR, 1999) |
| " To provide loading and maintenance dosing for patients with hepatic induction secondary to concurrent anticonvulsants." | 1.30 | Use of intravenous valproate in three pediatric patients with nonconvulsive or convulsive status epilepticus. ( Chicella, MF; Dalton, JT; Eades, SK; Hovinga, CA; Phelps, SJ; Rose, DF, 1999) |
| " The features of the stimulant-induced seizures were distinct and included the following: (1) the duration of convulsive activity was shortest for cocaine and longest for methamphetamine, (2) only MDMA produced a secondary clonic phase after the initial ictal event, and (3) 4-methylaminorex manifested a very steep dose-response curve." | 1.30 | Distinct features of seizures induced by cocaine and amphetamine analogs. ( Hanson, GR; Jensen, M; Johnson, M; White, HS, 1999) |
| "In this model, the threshold for seizures in rats is determined at short time intervals by applying ramp-shaped electrical pulse-trains directly to the cerebral cortex, allowing one to determine the time course of anti- or proconvulsant drug effects in individual rats." | 1.29 | Dose-dependent anticonvulsant and proconvulsant effects of nitric oxide synthase inhibitors on seizure threshold in a cortical stimulation model in rats. ( Gerecke, U; Koch, R; Löscher, W; Mevissen, M; Richter, A; Rundfeldt, C, 1995) |
| "Development of novel antiepileptic drugs (AEDs) requires determining the margin between the desired anticonvulsant effect and undesired adverse effects (AE) (therapeutic index)." | 1.29 | Kindling increases the sensitivity of rats to adverse effects of certain antiepileptic drugs. ( Hönack, D; Löscher, W, 1995) |
| "In all experiments, the PTZ seizure threshold was repeatedly determined in individual rats with chronically implanted catheters at daily intervals." | 1.29 | Comparison of anticonvulsant efficacy of valproate during prolonged treatment with one and three daily doses or continuous ("controlled release") administration in a model of generalized seizures in rats. ( Hönack, D; Löscher, W, 1995) |
| "The effects of AEDS on seizures of the tremor rat showed profiles similar to those observed in human absence seizures and also in absence-like seizures of SER." | 1.29 | Effect of antiepileptic drugs on absence-like seizures in the tremor rat. ( Amano, T; Fujita, Y; Hanaya, R; Matsubayashi, H; Sasa, M; Serikawa, T; Ujihara, H; Uozumi, T, 1995) |
| "PTZ-induced convulsions were partly antagonized by the GVG treatment." | 1.29 | The significance of extracellular GABA in the substantia nigra of the rat during seizures and anticonvulsant treatments. ( Sayin, U; Timmerman, W; Westerink, BH, 1995) |
| "He had been treated with valproate for seizures since the age of 2 years." | 1.29 | Haematological disturbances during long-term valproate therapy. ( Brichard, B; Cornu, G; Ninane, J; Scheiff, JM; Vermylen, C, 1994) |
| "5-5 mg/kg, CGP 37849 potentiated the adverse effects but not the anticonvulsant activity of 50 mg/kg valproate." | 1.29 | Effects of the competitive NMDA receptor antagonist, CGP 37849, on anticonvulsant activity and adverse effects of valproate in amygdala-kindled rats. ( Hönack, D; Löscher, W, 1993) |
| "8-CPT did not antagonize the seizure protection afforded by CBZ or SV." | 1.29 | Involvement of adenosine in postictal events in rats given electroshock. ( David, J; Joseph, T; Kulkarni, C, 1994) |
| "Myoclonus and seizures disappeared after discontinuation of L-dopa and the introduction of valproate sodium (VPA)." | 1.29 | Myoclonus and seizures in a patient with parkinsonism: induction by levodopa and its confirmation on SEPs. ( Hamada, T; Matsuura, T; Moriwaka, F; Tashiro, K; Yoshida, K, 1993) |
| "Seizures were attenuated or blocked by treatment with carbamazepine or sodium valproate." | 1.29 | Audiogenic seizures following global ischemia induced by chest compression in Long-Evans rats. ( Iyer, V; Keelen, P; Miller, J; Payne, RS; Reid, KH; Schurr, A; Tseng, M; Young, C, 1996) |
| "seizure severity, seizure duration, total duration of behavioural changes and afterdischarge duration." | 1.29 | D-23129: a potent anticonvulsant in the amygdala kindling model of complex partial seizures. ( Bartsch, R; Rostock, A; Rundfeldt, C; Tober, C, 1996) |
| "Seven patients with refractory seizure disorders and neuropsychiatric symptoms believed secondary to felbamate are presented." | 1.29 | Neuropsychiatric side effects related to treatment with felbamate. ( Brillman, J; Cavalier, J; Cress, K; Duffy, JD; McConnell, H; Snyder, PJ; Valeriano, J; Weilburg, J, 1996) |
| "Cerebral cavernous angioma (cavernoma) has previously been treated by resection for all presentations when surgically resectable." | 1.28 | Cerebral cavernous angioma: a potentially benign condition? Successful treatment in 16 cases. ( Churchyard, A; Grainger, K; Khangure, M, 1992) |
| "A series of 5 generalized tonic-clonic seizures within 30 min was induced by repeated transauricular electrical stimulation in mice." | 1.28 | Intravenous valproate: onset and duration of anticonvulsant activity against a series of electroconvulsions in comparison with diazepam and phenytoin. ( Hönack, D; Löscher, W, 1992) |
| "Women with heterozygous ornithine transcarbamylase deficiency may have no symptoms or have episodic, symptomatic hyperammonemia, which can be fatal." | 1.28 | Heterozygote ornithine transcarbamylase deficiency presenting as symptomatic hyperammonemia during initiation of valproate therapy. ( Callahan, K; Evans, B; Honeycutt, D; Rutledge, L, 1992) |
| "Behavior, seizures, death, EEGs, and ECGs were observed and measured." | 1.28 | Cocaine-induced respiratory depression and seizures are synergistic mechanisms of cocaine-induced death in rats. ( Albertson, TE; Derlet, RW; Tseng, CC, 1992) |
| "Seizures were repetitive and death occurred in 10." | 1.28 | Antiepileptic drugs delay the onset of seizures induced by aminophylline in conscious rats. ( David, J; Joseph, T; Kulkarni, C, 1992) |
| "Valproic acid has been implicated in at least 100 cases of fatal acute liver failure." | 1.28 | Incidental microvesicular steatosis due to valproic acid anticonvulsant therapy. ( Bacon, BR; Gholson, CF; Gonzalez, E; Netchvolodoff, CV; Ray, M; Scott, DA, 1991) |
| " The pathogenesis of VPA hepatotoxicity is unclear but may relate to the accumulation of a toxic metabolite of VPA which impairs fatty-acid oxidation." | 1.28 | The high incidence of valproate hepatotoxicity in infants may relate to familial metabolic defects. ( Applegarth, DA; Appleton, RE; Davidson, AG; Dimmick, JE; Farrell, K; Wong, LT, 1990) |
| "These seizures were unexplained by acute causes, infectious or cerebro-vascular." | 1.28 | [Cyclosporin and convulsions after cardiac transplantation]. ( Baulac, M; Cabrol, A; Cabrol, C; LaPlane, D; Smadja, D, 1989) |
| " Dosage adjustments and alterations in therapeutic regimen were allowed and another Cminss was measured after 1 to 12 months." | 1.28 | Usefulness of a single-dose prediction model for the determination of long-term maintenance therapy of valproic acid. ( Garnett, WR; Pellock, JM; Pugh, CB, 1989) |
| "There was a greater risk of recurrence among girls." | 1.28 | [Factors influencing the effectiveness of preventive treatment of febrile convulsions]. ( Armijo Simón, JA; Arteaga Manjón-Cabeza, R; Herranz Fernández, JL, 1989) |
| "ACTH4-7 pro-gly-pro decreased seizure threshold in the audiogenic epilepsy test, but did not prevent the motor convulsions." | 1.28 | [Anticonvulsive properties of peptide ACTH4-7 pro-gly-pro detected in amygdaloid kindling and audiogenic epilepsy in rats]. ( Artiukhova, MV; Chepurnov, SA; Chepurnova, NE; Kuznetsova, EIu; Nezavibat'ko, VN, 1989) |
| "The acute effects of seizures were also studied in both S/D rats and audiogenic seizure rats." | 1.27 | Effects of seizures and antiepileptic drugs on benzodiazepine receptors in rat brain. ( Laird, H; Mimaki, T; Yabuuchi, H; Yamamura, HI, 1984) |
| "DMCM seizures were antagonized by benzodiazepine (BZ) receptor antagonists, such as Ro 15-1788, CGS 8216 and several beta-carboline-3-carboxylates, which all fail to inhibit pentylenetetrazol seizures." | 1.27 | DMCM: a potent convulsive benzodiazepine receptor ligand. ( Petersen, EN, 1983) |
| " Significant differences occurred between initial and maintenance therapy in the mean apparent volume of distribution and in apparent VPA clearance, whereas VPA half-life remained relatively constant." | 1.27 | Pharmacokinetics of valproic acid in children: I. Multiple antiepileptic drug therapy. ( Cloyd, JC; Eggerth, RM; Fischer, JH; Kriel, RL; Sawchuk, RJ, 1983) |
| " Although the absorption of DS was delayed, the bioavailability of VA capsules and DS tablets was equivalent." | 1.27 | Gastrointestinal tolerance of divalproex sodium. ( Asconape, J; Karas, BJ; Penry, JK; Wilder, BJ, 1983) |
| "When phenobarbital was administered for several days, a strong induction of hepatic microsomal enzymes occurred." | 1.27 | Anticonvulsant potency of common antiepileptic drugs in the gerbil. ( Frey, HH; Löscher, W; Reiche, R; Schultz, D, 1983) |
| "Most electrically induced seizures involve forebrain structures, such as the amygdala or frontal cortex, but the following studies characterized a specific anatomic site in the inferior colliculus which generated seizure-like behavior after a single, low current electrical stimulation." | 1.27 | Electrically elicited seizures from the inferior colliculus: a potential site for the genesis of epilepsy? ( Breese, GR; Frye, GD; Greenwood, RS; McCown, TJ, 1984) |
| "In chemically elicited seizures in mice, CM 40142 exhibited a higher potency than sodium valproate in antagonizing anti-GABAergic agents." | 1.27 | Anticonvulsant activity of 4,9-dioxo-5,10-diazatetradecane (CM 40142), a new GABA derivative, in mice and photosensitive baboons). ( Bizière, K; Calassi, R; Chambon, JP; Leyris, R; Maruani, J; Molimard, JC; Rodier, D; Roncucci, R; Sigault, G, 1984) |
| "However, ethosuximide must act against generalized absence seizures and against pentylenetetrazol-induced seizures by a third, as yet unknown, mechanism." | 1.27 | Anticonvulsant drug mechanisms of action. ( Macdonald, RL; McLean, MJ; Skerritt, JH, 1985) |
| "The results show that aminophylline convulsions are relatively resistant to antiepileptic drugs and suggest that antagonists of excitatory transmission are potential antiaminophylline drugs." | 1.27 | Inhibition of aminophylline-induced convulsions in mice by antiepileptic drugs and other agents. ( Czuczwar, SJ; Janusz, W; Kleinrok, Z; Wamil, A, 1987) |
| "Maximal seizures were induced by electroshock (MES) and the chemical convulsants pentetrazol (PTZ), picrotoxin (PTX), bicuculline (BIC), isoniazid (INH), nicotine (NIC) and strychnine (STR)." | 1.27 | Etifoxine: evaluation of its anticonvulsant profile in mice in comparison with sodium valproate, phenytoin and clobazam. ( Kruse, HJ; Kuch, H, 1985) |
| "Kindled seizures were almost completely blocked by treatment with carbamazepine, whereas the effect of valproic acid was partial, suppressing only generalized seizures." | 1.27 | Effects of carbamazepine and valproic acid on brain immunoreactive somatostatin and gamma-aminobutyric acid in amygdaloid-kindled rats. ( Higuchi, T; Igarashi, Y; Kato, N; Minatogawa, Y; Nagaki, S; Ohshima, H; Takazawa, A; Watanabe, N; Yamazaki, J; Yamazaki, O, 1986) |
| "QUIN seizures showed particular sensitivity to carbamazepine (5 mg/kg) but were resistant to diphenylhydantoin unless a relatively high dose was used (100 mg/kg)." | 1.27 | Anticonvulsant drugs effective against human temporal lobe epilepsy prevent seizures but not neurotoxicity induced in rats by quinolinic acid: electroencephalographic, behavioral and histological assessments. ( Samanin, R; Tullii, M; Vezzani, A; Wu, HQ, 1986) |
| "Thus, the seizure-facilitating nigral efferents may be subject to inhibition by both GABA and opiates and may normally be driven by substance P." | 1.27 | Role of the substantia nigra in GABA-mediated anticonvulsant actions. ( Gale, K, 1986) |
| " In the case of diazepam, clonazepam, ethosuximide or trimethadione, the TE/TF ratio was decreased dose-dependently, but the slope of the dose-response regression line was less steep than that obtained by the administration of PB, PNT, CBZ, VPA or primidone." | 1.27 | [The correlation between concentrations of anticonvulsive drugs in the brain and various parameters of maximal electroshock seizures in mice]. ( Kishita, C, 1986) |
| "In over 80% of children with complete seizure control the ranges of total VPA concentration were 140-420 mumol/L with GLC methods and 210-560 mumol/L with EMIT methods." | 1.27 | Free and total serum valproate concentrations: their relationship to seizure control, liver enzymes and plasma ammonia in children. ( Abbott, FS; Applegarth, DA; Farrell, K; Jan, JE; Orr, JM; Wong, PK, 1986) |
| "Tonic-clonic (maximal) seizures were induced by maximal electroshock (MES; 12 mA, 200 ms) and clonic (threshold) seizures by pentetrazol (PTZ; 85 mg/kg s." | 1.27 | Potentiation of clobazam's anticonvulsant activity by etifoxine, a non-benzodiazepine tranquilizer, in mice. Comparison studies with sodium valproate. ( Kruse, HJ; Kuch, H, 1986) |
| "A diagnosis of benign juvenile myoclonic epilepsy was made, and the seizures were controlled with valproic acid." | 1.27 | Benign juvenile myoclonic epilepsy. ( Dean, C; Hauswald, M, 1987) |
| "Children with seizure disorders frequently are treated with anticonvulsant medications such as clonazepam, valproic acid, carbamazepine, and ethosuximide, which cannot be given parenterally." | 1.27 | Rectal anticonvulsants in pediatric practice. ( Laney, SM; Woody, RC, 1988) |
| " Purely additive interactions were found for the anticonvulsant effect when valproate was combined with carbamazepine as well as with phenobarbital." | 1.27 | Anticonvulsant potency and neurotoxicity of valproate alone and in combination with carbamazepine or phenobarbital. ( Bourgeois, BF, 1988) |
| "The effects of pregnancy on seizure excitability as well as antiepileptic drug disposition and efficacy were studied in the mouse during late gestation." | 1.27 | Effects of pregnancy on seizure threshold and the disposition and efficacy of antiepileptic drugs in the mouse. ( Kuhnz, W; Löscher, W; Nau, H, 1985) |
| " The PTZ infusion model was tested in a preliminary dose-response study of the anticonvulsant valproic acid (VPA)." | 1.27 | A timed intravenous pentylenetetrazol infusion seizure model for quantitating the anticonvulsant effect of valproic acid in the rat. ( Pollack, GM; Shen, DD, 1985) |
| "According to our convulsion intensity scoring system, these animals have an audiogenic response score (ARS) of 3 and the colony is designated the GEPR-3 colony." | 1.27 | Anticonvulsant drugs and the genetically epilepsy-prone rat. ( Dailey, JW; Jobe, PC, 1985) |
| "A moderate amount of seizure control was obtained at blood levels of 60-91 micrograms/ml (DPA) and complete blockade occurred at levels greater than 100 micrograms/ml DPA." | 1.26 | EEG and anticonvulsant effects of dipropylacetic acid and dipropylacetamide in the baboon Papio papio. ( Ehlers, CL; Killam, EK; Mulbry, LW, 1980) |
| " The dose-response curve for naloxone against seizure activity induced by leucine enkephalin was the same as that in gamma-hydroxybutyrate-induced petit mal." | 1.26 | Anticonvulsants specific for petit mal antagonize epileptogenic effect of leucine enkephalin. ( Bearden, LJ; Snead, OC, 1980) |
| "In the case of picrotoxin induced convulsive seizures where there is an alteration at the GABA receptor level, ther is a lack of efficiency after nDPA treatment which increases GABA at the synaptic level." | 1.26 | [Effect of sodium dipropylacetate on experimental convulsions produced by pentetrazole and picrotoxin]. ( Ciesielski, L; Mandel, P; Simler, S, 1981) |
| " Thus in adequate dosage both phenobarbitone and valproic acid were significantly better than no treatment in preventing febrile convulsions (p less than 0." | 1.26 | Successful prophylaxis against febrile convulsions with valproic acid or phenobarbitone. ( Smith, JA; Wallace, SJ, 1980) |
| "Clonazepam was ineffective in treating the seizures and, in high doses, seemed to exacerbate the porphyria." | 1.26 | Seizure management in acute hepatic porphyria: risks of valproate and clonazepam. ( Bonkowsky, HL; Emery, S; Sinclair, JF; Sinclair, PR, 1980) |
| "This syndrome consists of sustained seizures, resembling amygdaloid kindled seizures, and acute destruction of neural elements in limbic brain regions (amygdala, olfactory cortex, hippocampus, lateral septum and several thalamic nuclei)." | 1.26 | Only certain anticonvulsants protect against kainate neurotoxicity. ( Fuller, TA; Olney, JW, 1981) |
| "Two hundred and seventy eight absence seizures were recorded from 60 patients by an intensive monitoring device." | 1.26 | Analytic study of epileptic absence seizures and effect of sodium valproate treatment. ( Kakegawa, N; Miyakoshi, M; Morikawa, T; Osawa, T; Seino, M; Wada, T; Yagi, K, 1980) |
| "The time to seizures was increased nearly five times by clonazepam and over three times by very small amounts of propylene glycol." | 1.26 | Protection from oxygen-induced seizures by clonazepam and propylene glycol. ( Beckman, DL; Crittenden, DJ, 1981) |
| "A residual effect of DPA against seizures induced by pentetrazole was shown, i." | 1.26 | Anticonvulsant and antiaggressive properties of di-n-propyl acetate after repeated treatment. ( Ciesielski, L; Klein, M; Mandel, P; Simler, S, 1982) |
| "The diagnosis of functional seizures is difficult and emotional factors may be important in the cause and triggering of seizures." | 1.26 | Differentiating between organic and functional seizures: a common diagnostic problem. ( Chambers, BR; Vajda, FJ, 1981) |
| "In the maximal seizure tests, tonic hindlimb extension was always abolished at plasma valproic acid concentrations of 225 microgram ml-1 and above." | 1.26 | The relationship between plasma concentration of valproic acid and its anticonvulsant and behavioural effects in the rat. ( Howe, GM; Howe, SJ; Tulloch, IF; Walter, DS, 1982) |
| "The bioavailability of commercially available valproic acid (VPA) syrup was studied following rectal administration in both dogs and children." | 1.26 | Bioavailability of rectally administered valproic acid syrup. ( Cloyd, JC; Kriel, RL, 1981) |
| "Audiogenic seizure-prone mice (DBA/2J) were exposed to a broad band noise source." | 1.26 | Audiogenic seizure-induced changes in energy metabolites in cerebral cortical and cerebellar layers. ( McCandless, DW; Schwartzenburg, FC, 1982) |
| "Isoniazid is a useful chemical convulsant in that metabolic events associated with the preseizure state can be easily examined." | 1.26 | Isoniazid induced seizures and cerebral cortical and cerebellar energy metabolism. ( Abel, MS; McCandless, DW; Schwartzenburg, FC, 1982) |
| "Valproic acid was administered to a neonate (gestational age of 39 weeks) at 24 days post partum in an initial single dose of 7." | 1.26 | Pharmacokinetic study of valproic acid in a neonate. ( Budnik, D; Hall, KW; Irvine-Meek, JM; Leroux, M; Otten, NH; Seshia, SS, 1982) |
| " A twice daily dosage regime was satisfactory." | 1.26 | Sodium valproate (Epilim) in epilepsy: a trial. ( Briant, RH; Foote, SE; Wallis, WE, 1978) |
| "Bromide was effective at subsedative doses." | 1.26 | Sodium bromide and sodium valproate: effective suppressants of ethanol withdrawal reactions in mice. ( Goldstein, DB, 1979) |
| "Twenty-seven children with uncontrolled seizures, predominantly akinetic and myoclonic, were treated with this drug." | 1.26 | Valproate sodium in refractory seizures: a study of efficacy. ( Botsford, E; Freeman, JM; Vining, EP, 1979) |
| "Thirty children with simple febrile convulsions were treated with sodium valproate following their second convulsion." | 1.26 | Sodium valproate in the prophylaxis of simple febrile convulsions. ( Evans-Jones, LG; Groom, PJ; Kindley, AD; Williams, AJ, 1979) |
| "The patients all had frequent clinical seizures and generalized spike-wave discharges." | 1.26 | Sodium valproate: serial monitoring of EEG and serum levels. ( Binnie, CD; de Beer-Pawlikowski, NK; Goedhart, DM; Gutter, T; Meijer, JW; Meinardi, H; Rowan, AJ; van der Geest, P, 1979) |
| "In a certain percentage of patients seizures are abolished or diminish in frequency only on attaining such a serum level." | 1.26 | [The serum concentration of anticonvulsants -- pharmacokinetic findings and practical therapeutic applications (author's transl)]. ( Deisenhammer, E; Sommer, R, 1979) |
| "n-DPA proved to be most active against convulsions induced by picrotoxin (ED50 200 mg/kg orally), which might indicate a role of the elevation of the central levels of gamma-aminobutyric acid in the anticonvulsant effect of the drug." | 1.26 | Di-n-propylacetic acid--profile of anticonvulsant activity in mice. ( Frey, HH; Löscher, W, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 204 (19.43) | 18.7374 |
| 1990's | 166 (15.81) | 18.2507 |
| 2000's | 198 (18.86) | 29.6817 |
| 2010's | 348 (33.14) | 24.3611 |
| 2020's | 134 (12.76) | 2.80 |
| Authors | Studies |
|---|---|
| Edafiogho, IO | 3 |
| Hinko, CN | 3 |
| Chang, H | 3 |
| Moore, JA | 3 |
| Mulzac, D | 1 |
| Nicholson, JM | 2 |
| Scott, KR | 2 |
| Tomczuk, BE | 1 |
| Taylor, CR | 1 |
| Moses, LM | 1 |
| Sutherland, DB | 1 |
| Lo, YS | 1 |
| Johnson, DN | 1 |
| Kinnier, WB | 1 |
| Kilpatrick, BF | 1 |
| Sasaki, H | 1 |
| Mori, Y | 1 |
| Nakamura, J | 1 |
| Shibasaki, J | 1 |
| Kohn, H | 8 |
| Sawhney, KN | 2 |
| LeGall, P | 1 |
| Robertson, DW | 2 |
| Leander, JD | 2 |
| Wall, GM | 1 |
| Baker, JK | 1 |
| Chimirri, A | 2 |
| De Sarro, A | 3 |
| De Sarro, G | 3 |
| Grasso, S | 1 |
| Trimarchi, GR | 2 |
| Zappalà, M | 1 |
| Kadaba, PK | 1 |
| Clark, CR | 2 |
| Lin, CM | 2 |
| Sansom, RT | 2 |
| Conley, JD | 1 |
| Norris, GN | 1 |
| Brouillette, WJ | 1 |
| Grunewald, GL | 1 |
| Mehta, NB | 1 |
| Diuguid, CA | 1 |
| Soroko, FE | 1 |
| Palaty, J | 1 |
| Abbott, FS | 2 |
| Bardel, P | 1 |
| Farrar, VA | 1 |
| Ciechanowicz-Rutkowska, M | 1 |
| Grochowski, J | 1 |
| Serda, P | 1 |
| Pilati, T | 1 |
| Filippini, G | 1 |
| el-Assadi, A | 1 |
| Kane, JM | 2 |
| Staeger, MA | 1 |
| Dalton, CR | 1 |
| Miller, FP | 1 |
| Dudley, MW | 1 |
| Ogden, AM | 1 |
| Kehne, JH | 2 |
| Ketteler, HJ | 1 |
| McCloskey, TC | 2 |
| Senyah, Y | 2 |
| Dimmock, JR | 1 |
| Puthucode, RN | 1 |
| Smith, JM | 1 |
| Hetherington, M | 1 |
| Quail, JW | 1 |
| Pugazhenthi, U | 1 |
| Lechler, T | 1 |
| Stables, JP | 9 |
| Carson, JR | 1 |
| Carmosin, RJ | 1 |
| Pitis, PM | 1 |
| Vaught, JL | 1 |
| Almond, HR | 1 |
| Wolf, HH | 3 |
| Swinyard, EA | 4 |
| White, HS | 10 |
| Geurts, M | 1 |
| Poupaert, JH | 2 |
| Scriba, GK | 1 |
| Lambert, DM | 2 |
| Pevarello, P | 1 |
| Bonsignori, A | 1 |
| Dostert, P | 1 |
| Heidempergher, F | 1 |
| Pinciroli, V | 1 |
| Colombo, M | 1 |
| McArthur, RA | 1 |
| Salvati, P | 1 |
| Post, C | 1 |
| Fariello, RG | 1 |
| Varasi, M | 1 |
| Ucar, H | 1 |
| Van derpoorten, K | 1 |
| Cacciaguerra, S | 1 |
| Spampinato, S | 1 |
| Depovere, P | 1 |
| Isa, M | 1 |
| Masereel, B | 1 |
| Delarge, J | 1 |
| Andurkar, SV | 1 |
| Béguin, C | 1 |
| LeTiran, A | 1 |
| Sobol, E | 3 |
| Bialer, M | 19 |
| Yagen, B | 17 |
| Xie, ZF | 1 |
| Chai, KY | 1 |
| Piao, HR | 1 |
| Kwak, KC | 1 |
| Quan, ZS | 1 |
| Yogeeswari, P | 1 |
| Sriram, D | 1 |
| Thirumurugan, R | 1 |
| Raghavendran, JV | 1 |
| Sudhan, K | 1 |
| Pavana, RK | 1 |
| Stables, J | 1 |
| Azam, F | 1 |
| Alkskas, IA | 1 |
| Khokra, SL | 1 |
| Prakash, O | 1 |
| Gitto, R | 1 |
| Pagano, B | 1 |
| Citraro, R | 1 |
| Scicchitano, F | 1 |
| Shimshoni, JA | 5 |
| Sharma, G | 1 |
| Park, JY | 1 |
| Park, MS | 1 |
| Kaufmann, D | 2 |
| Devor, M | 1 |
| Karakurt, A | 1 |
| Ozalp, M | 1 |
| Işik, S | 1 |
| Dalkara, S | 1 |
| Hen, N | 6 |
| Wlodarczyk, B | 4 |
| Finnell, RH | 9 |
| Morieux, P | 1 |
| Salomé, C | 2 |
| Park, KD | 1 |
| King, AM | 1 |
| Dinsmore, J | 1 |
| Salomé-Grosjean, E | 1 |
| De Ryck, M | 1 |
| Kaminski, R | 3 |
| Valade, A | 1 |
| Pękala, E | 4 |
| Waszkielewicz, AM | 3 |
| Szneler, E | 1 |
| Walczak, M | 1 |
| Marona, H | 3 |
| He, X | 1 |
| Zhong, M | 2 |
| Zhang, T | 2 |
| Wu, W | 1 |
| Wu, Z | 3 |
| Xiao, Y | 1 |
| Hu, X | 3 |
| Kamiński, K | 10 |
| Obniska, J | 9 |
| Chlebek, I | 1 |
| Wiklik, B | 1 |
| Rzepka, S | 1 |
| Mishra, RK | 1 |
| Baker, MT | 1 |
| Kumari, S | 2 |
| Mishra, CB | 1 |
| Tiwari, M | 1 |
| Rapacz, A | 11 |
| Łuszczki, JJ | 12 |
| Latacz, G | 4 |
| Kieć-Kononowicz, K | 3 |
| Filipek, B | 6 |
| Torregrosa, R | 1 |
| Yang, XF | 1 |
| Dustrude, ET | 1 |
| Cummins, TR | 1 |
| Khanna, R | 1 |
| Zagaja, M | 6 |
| Andres-Mach, M | 7 |
| Rybka, S | 5 |
| Powroźnik, B | 1 |
| Żmudzki, P | 3 |
| Edayadulla, N | 1 |
| Ramesh, P | 1 |
| Gunia-Krzyżak, A | 2 |
| Żesławska, E | 2 |
| Słoczyńska, K | 2 |
| Koczurkiewicz, P | 1 |
| Nitek, W | 2 |
| Żelaszczyk, D | 2 |
| Szkaradek, N | 1 |
| Kuder, K | 1 |
| Łażewska, D | 1 |
| Schwed, JS | 1 |
| Karcz, T | 1 |
| Stark, H | 1 |
| Karolak-Wojciechowska, J | 1 |
| Abram, M | 3 |
| Góra, M | 2 |
| Sałat, K | 2 |
| Mawasi, H | 2 |
| Bibi, D | 1 |
| Pańczyk, K | 1 |
| Liu, X | 2 |
| Tao, J | 1 |
| Zhang, S | 1 |
| Lan, W | 1 |
| Wang, C | 1 |
| Ji, Y | 1 |
| Cao, C | 1 |
| Grover, G | 1 |
| Nath, R | 1 |
| Bhatia, R | 1 |
| Akhtar, MJ | 1 |
| Alhamzani, AG | 1 |
| Yousef, TA | 1 |
| Abou-Krisha, MM | 1 |
| Raghu, MS | 1 |
| Yogesh Kumar, K | 1 |
| Prashanth, MK | 2 |
| Jeon, BH | 1 |
| Hussain, M | 1 |
| Rashid, H | 1 |
| Katyal, J | 4 |
| Müffelmann, B | 1 |
| Hagemann, A | 1 |
| Knaak, N | 1 |
| Bien, CG | 1 |
| Muthaffar, OY | 1 |
| Almahmudi, SM | 1 |
| Alrabghi, MO | 1 |
| Bin Mahfouz, MM | 1 |
| Alfawaz, NS | 1 |
| Cerulli Irelli, E | 3 |
| Morano, A | 4 |
| Orlando, B | 2 |
| Salamone, EM | 1 |
| Fanella, M | 4 |
| Fattouch, J | 4 |
| Manfredi, M | 4 |
| Giallonardo, AT | 4 |
| Di Bonaventura, C | 4 |
| Liu, J | 4 |
| Tai, YJ | 1 |
| Wang, LN | 4 |
| Singh, S | 2 |
| Singh, TG | 2 |
| Singh, M | 1 |
| Najda, A | 1 |
| Nurzyńska-Wierdak, R | 1 |
| Almeer, R | 1 |
| Kamel, M | 1 |
| Abdel-Daim, MM | 1 |
| Viamontes, CG | 1 |
| Castillo Gonzalez, J | 1 |
| Najjar, F | 1 |
| Cook, EH | 1 |
| Chauhan, V | 1 |
| Sharma, M | 2 |
| Kapur, A | 1 |
| Garg, GK | 1 |
| Can Kantarci, B | 1 |
| Sanli, A | 1 |
| Gavas, S | 1 |
| Toplu, A | 1 |
| Nur Turgan Asik, Z | 1 |
| Tugce Cilingir-Kaya, O | 1 |
| Gulcebi Idrizoglu, M | 1 |
| Ercan, F | 1 |
| Onat, F | 1 |
| Tsai, CM | 1 |
| Chang, SF | 1 |
| Hofi, E | 1 |
| Medvedovsky, M | 1 |
| Nassar, M | 1 |
| Khana Levy, N | 1 |
| Eyal, S | 1 |
| Ekstein, D | 1 |
| Chen, Y | 3 |
| Fang, M | 1 |
| Wu, P | 2 |
| Xie, Z | 1 |
| Wu, H | 1 |
| Wu, Q | 1 |
| Xu, S | 1 |
| Li, Y | 3 |
| Sun, B | 1 |
| Pang, B | 1 |
| Zheng, N | 1 |
| Zhang, J | 2 |
| You, C | 2 |
| Kılıç, B | 1 |
| Serdaroğlu, E | 1 |
| Polat, BG | 1 |
| İnce, T | 1 |
| Esenülkü, G | 1 |
| Topçu, Y | 1 |
| Serdaroğlu, A | 2 |
| Haspolat, Ş | 1 |
| Tekgül, H | 1 |
| Okuyaz, Ç | 1 |
| Cansu, A | 2 |
| Aydın, K | 1 |
| Coralic, Z | 1 |
| Kapur, J | 1 |
| Olson, KR | 1 |
| Chamberlain, JM | 1 |
| Overbeek, D | 1 |
| Silbergleit, R | 1 |
| Tsyvunin, V | 1 |
| Shtrygol, S | 1 |
| Mishchenko, M | 1 |
| Shtrygol, D | 1 |
| Rzayev, E | 1 |
| Amanvermez, R | 1 |
| Gün, S | 1 |
| Tiryaki, ES | 1 |
| Arslan, G | 1 |
| Mir, A | 2 |
| Alghamdi, A | 1 |
| Alotaibi, W | 1 |
| Samreen, D | 1 |
| Alotaibi, M | 1 |
| Albaradie, R | 2 |
| Bashir, S | 1 |
| Chen, J | 2 |
| Zhuang, X | 1 |
| Chen, X | 1 |
| Zeng, J | 1 |
| Wang, R | 1 |
| Miao, J | 1 |
| Winter, Y | 1 |
| Uphaus, T | 1 |
| Sandner, K | 1 |
| Klimpe, S | 1 |
| Stuckrad-Barre, SV | 1 |
| Groppa, S | 1 |
| van der Meer, PB | 4 |
| Taphoorn, MJB | 4 |
| Koekkoek, JAF | 4 |
| Panda, SP | 1 |
| Dhurandhar, Y | 1 |
| Agrawal, M | 1 |
| Pipek, LZ | 1 |
| Pipek, HZ | 1 |
| Castro, LHM | 1 |
| Samanta, D | 2 |
| Zorina, VN | 1 |
| Bespalov, AY | 1 |
| Krasnov, KA | 1 |
| Melekhova, AS | 1 |
| Reinuk, VL | 1 |
| Bobylova, MY | 1 |
| Mukhin, KY | 1 |
| Kuzmich, GV | 1 |
| Glukhova, LY | 1 |
| Pylayeva, OA | 1 |
| Gruppuso, PA | 1 |
| Ahmed, R | 1 |
| Adashi, EY | 1 |
| Kondasinghe, JS | 1 |
| Look, ML | 1 |
| Moffat, P | 1 |
| Bradley, K | 1 |
| Zou, X | 1 |
| Zhu, Z | 1 |
| Guo, Y | 2 |
| Zhang, H | 2 |
| Liu, Y | 3 |
| Cui, Z | 1 |
| Ke, Z | 1 |
| Jiang, S | 1 |
| Tong, Y | 1 |
| Mao, Y | 1 |
| Chen, L | 3 |
| Wang, D | 2 |
| Pang, W | 1 |
| Lu, S | 1 |
| Zheng, R | 1 |
| Li, X | 3 |
| Yang, S | 1 |
| Feng, Y | 1 |
| Wang, S | 4 |
| Guo, J | 1 |
| Zhou, S | 1 |
| Jiménez, M | 1 |
| Grau-López, L | 1 |
| Ciurans, J | 1 |
| García-Esperón, C | 1 |
| Fumanal, A | 1 |
| Barambio, S | 1 |
| Chíes, E | 1 |
| Codina, M | 1 |
| Becerra, JL | 1 |
| Jiang, Y | 2 |
| Zhou, X | 2 |
| Jain, P | 2 |
| Aneja, S | 2 |
| Cunningham, J | 1 |
| Arya, R | 1 |
| Sharma, S | 5 |
| Soto-Insuga, V | 1 |
| González-Alguacil, E | 1 |
| García-Peñas, JJ | 1 |
| Dirven, L | 3 |
| Fiocco, M | 3 |
| Vos, MJ | 3 |
| Kouwenhoven, MCM | 3 |
| van den Bent, MJ | 3 |
| Myren-Svelstad, S | 1 |
| Jamali, A | 1 |
| Ophus, SS | 1 |
| D'gama, PP | 1 |
| Ostenrath, AM | 1 |
| Mutlu, AK | 1 |
| Hoffshagen, HH | 1 |
| Hotz, AL | 1 |
| Neuhauss, SCF | 1 |
| Jurisch-Yaksi, N | 1 |
| Yaksi, E | 1 |
| Yi, Z | 1 |
| Song, Z | 1 |
| Xue, J | 1 |
| Yang, C | 1 |
| Li, F | 1 |
| Pan, H | 2 |
| Feng, X | 1 |
| Zhang, Y | 2 |
| Gan, J | 1 |
| Wang, J | 3 |
| Bleakley, LE | 1 |
| McKenzie, CE | 1 |
| Reid, CA | 1 |
| Wang, Y | 4 |
| Wang, G | 1 |
| Lu, J | 1 |
| Li, Z | 1 |
| Heydari, FS | 3 |
| Gorji Valokola, M | 3 |
| Mehri, S | 3 |
| Abnous, K | 3 |
| Roohbakhsh, A | 3 |
| Ayala-Guerrero, F | 2 |
| Castro-Domínguez, D | 2 |
| Mateos-Salgado, EL | 2 |
| Mexicano-Medina, G | 2 |
| Gutiérrez-Chávez, CA | 2 |
| Pizarro, J | 1 |
| O'Sullivan, S | 1 |
| Walker, MC | 2 |
| Bojar, H | 2 |
| Góralczyk, A | 1 |
| Skalicka-Woźniak, K | 3 |
| Bertoncello, KT | 2 |
| Bonan, CD | 2 |
| Bernat, P | 1 |
| Kołodziejczyk, P | 1 |
| Tutka, P | 6 |
| Ali, S | 1 |
| Stanley, J | 1 |
| Davis, S | 1 |
| Keenan, N | 1 |
| Scheffer, IE | 1 |
| Sadleir, LG | 1 |
| de Oliveira Ferreira, E | 1 |
| Pessoa Gomes, JM | 1 |
| Neves, KRT | 1 |
| Lima, FAV | 1 |
| de Barros Viana, GS | 1 |
| de Andrade, GM | 1 |
| Mori, T | 3 |
| Sakamoto, M | 1 |
| Tayama, T | 2 |
| Goji, A | 3 |
| Toda, Y | 3 |
| Fujita, A | 1 |
| Mizuguchi, T | 1 |
| Urushihara, M | 1 |
| Matsumoto, N | 1 |
| Dongxiao, QU | 1 |
| Yiqin, GE | 1 |
| Limin, Z | 1 |
| Liji, C | 1 |
| Yonghua, X | 1 |
| Jiwei, C | 1 |
| Jie, T | 1 |
| Guoyi, LI | 1 |
| Yudan, Z | 1 |
| Qian, X | 1 |
| Jin, K | 1 |
| Zhou, SM | 1 |
| McLean, B | 1 |
| Roberts, E | 1 |
| Baines, R | 1 |
| Hannon, P | 1 |
| Ashby, S | 1 |
| Newman, C | 1 |
| Sen, A | 1 |
| Wilkinson, E | 1 |
| Laugharne, R | 1 |
| Shankar, R | 1 |
| Marques, VD | 1 |
| Hackbart, BA | 1 |
| Guilhoto, LM | 1 |
| Duarte, JTC | 1 |
| Peixoto-Santos, JE | 1 |
| Yacubian, EMT | 1 |
| Bittar Guaranha, MS | 1 |
| Günay, Ç | 1 |
| Sarikaya Uzan, G | 1 |
| Özsoy, Ö | 1 |
| Hiz Kurul, S | 1 |
| Yiş, U | 1 |
| Yanaga, M | 1 |
| Okamoto, N | 1 |
| Hashimoto, R | 1 |
| Igata, R | 1 |
| Konishi, Y | 1 |
| Ikenouchi, A | 1 |
| Isomoto, N | 1 |
| Shinkai, T | 1 |
| Harada, M | 1 |
| Yoshimura, R | 1 |
| Jomaa, N | 1 |
| Nasreddine, W | 1 |
| Hmeimess, G | 1 |
| Beaini, S | 1 |
| Beydoun, A | 2 |
| Hotait, M | 1 |
| Wazne, J | 1 |
| Wang, XL | 1 |
| Tian, YN | 1 |
| Chen, C | 1 |
| Peng, J | 2 |
| Skiba, A | 1 |
| Pellegata, D | 1 |
| Morozova, V | 1 |
| Kozioł, E | 1 |
| Budzyńska, B | 1 |
| Lee, SM | 1 |
| Gertsch, J | 1 |
| Mizuno, K | 1 |
| Capparelli, EV | 2 |
| Fukuda, T | 2 |
| Dong, M | 1 |
| Adamson, PC | 2 |
| Blumer, JL | 1 |
| Cnaan, A | 2 |
| Clark, PO | 2 |
| Reed, MD | 1 |
| Shinnar, S | 2 |
| Vinks, AA | 1 |
| Glauser, TA | 2 |
| Chu, H | 1 |
| Zhang, X | 2 |
| Shi, J | 1 |
| Zhou, Z | 1 |
| Yang, X | 2 |
| Yi, Y | 1 |
| Cheng, L | 2 |
| Chen, H | 3 |
| Hu, Y | 1 |
| Alhiniah, M | 1 |
| Alshahrani, A | 1 |
| Rajab, R | 1 |
| Alelyani, R | 1 |
| Badawi, A | 1 |
| Abbar, A | 1 |
| Abdulsbhan, M | 1 |
| Alrajhi, A | 1 |
| Muthaffar, O | 1 |
| Jan, M | 1 |
| Hope, OA | 1 |
| Harris, KM | 1 |
| Kimura, Y | 1 |
| Iwasaki, M | 1 |
| Chand, P | 1 |
| Angez, M | 1 |
| Hameed, AN | 1 |
| Kirmani, S | 1 |
| MacKeigan, D | 1 |
| Feja, M | 1 |
| Meller, S | 1 |
| Deking, L | 1 |
| Javadova, A | 1 |
| Veenhuis, A | 1 |
| Felmy, F | 1 |
| Gernert, M | 2 |
| Vajda, F | 2 |
| O'Brien, T | 1 |
| Graham, J | 1 |
| Hitchcock, A | 1 |
| Perucca, P | 1 |
| Lander, C | 1 |
| Eadie, M | 1 |
| Zaccara, G | 1 |
| Lattanzi, S | 2 |
| Brigo, F | 4 |
| Rawat, C | 1 |
| Kukal, S | 1 |
| Kushwaha, S | 1 |
| Agarwal, R | 1 |
| Srivastava, AK | 2 |
| Kukreti, R | 1 |
| Socała, K | 2 |
| Jakubiec, M | 2 |
| Pieróg, M | 1 |
| Nieoczym, D | 2 |
| Gawel, K | 1 |
| Esguerra, CV | 3 |
| Lubelska, A | 1 |
| Szulczyk, B | 1 |
| Szewczyk, A | 1 |
| Wlaź, P | 2 |
| Fu, J | 1 |
| Peng, L | 2 |
| Wang, W | 2 |
| He, H | 1 |
| Zeng, S | 1 |
| Chen, TC | 1 |
| Sanoria, A | 1 |
| Arora, R | 2 |
| Dokania, P | 1 |
| Revilla Orías, MD | 1 |
| Alonso, X | 1 |
| Campistol, J | 1 |
| Macaya, A | 1 |
| Escofet, C | 1 |
| Fons, C | 1 |
| Niquet, J | 1 |
| Lumley, L | 1 |
| Baldwin, R | 1 |
| Rossetti, F | 2 |
| Schultz, M | 1 |
| de Araujo Furtado, M | 2 |
| Suchomelova, L | 1 |
| Naylor, D | 1 |
| Franco-Estrada, I | 1 |
| Wasterlain, CG | 1 |
| Calle-Lopez, Y | 1 |
| Kotagal, P | 1 |
| Knight, EP | 1 |
| Meenu, M | 1 |
| Reeta, KH | 1 |
| Dinda, AK | 1 |
| Kottarath, SK | 1 |
| Gupta, YK | 8 |
| de Jong, VMT | 1 |
| Moons, KGM | 1 |
| Riley, RD | 1 |
| Tudur Smith, C | 7 |
| Marson, AG | 14 |
| Eijkemans, MJC | 1 |
| Debray, TPA | 1 |
| Peng, X | 1 |
| Yan, Y | 1 |
| Chen, R | 1 |
| Wang, X | 2 |
| Xu, X | 1 |
| Cocchi, E | 2 |
| Casciato, S | 3 |
| Albini, M | 2 |
| Avorio, F | 1 |
| Basili, LM | 1 |
| Fisco, G | 2 |
| Barone, FA | 2 |
| Mascia, A | 2 |
| D'Aniello, A | 2 |
| Quarato, P | 1 |
| Di Gennaro, G | 2 |
| Keni, RR | 1 |
| Jose, M | 1 |
| A S, R | 1 |
| Baishya, J | 1 |
| Sankara Sarma, P | 1 |
| Thomas, SV | 1 |
| Li, B | 2 |
| Li, J | 3 |
| Wang, L | 2 |
| Jiang, Z | 2 |
| Harris, L | 1 |
| Lowes, O | 1 |
| Angus-Leppan, H | 1 |
| Mansoor, M | 1 |
| Mesiya, MH | 1 |
| Chachar, AS | 1 |
| Cross, JH | 1 |
| Caraballo, RH | 4 |
| Nabbout, R | 2 |
| Vigevano, F | 1 |
| Guerrini, R | 1 |
| Lagae, L | 1 |
| Arfman, IJ | 1 |
| Wammes-van der Heijden, EA | 1 |
| Ter Horst, PGJ | 1 |
| Lambrechts, DA | 1 |
| Wegner, I | 1 |
| Touw, DJ | 1 |
| Gasser, M | 1 |
| Boonsimma, P | 1 |
| Netbaramee, W | 1 |
| Wechapinan, T | 1 |
| Srichomthomg, C | 1 |
| Ittiwut, C | 1 |
| Krenn, M | 1 |
| Zimprich, F | 1 |
| Milenkovic, I | 1 |
| Abicht, A | 1 |
| Biskup, S | 1 |
| Roser, T | 1 |
| Shotelersuk, V | 1 |
| Tacke, M | 1 |
| Kuersten, M | 1 |
| Wagner, M | 1 |
| Borggraefe, I | 1 |
| Suphapeetiporn, K | 1 |
| von Stülpnagel, C | 1 |
| Asadi-Pooya, AA | 1 |
| Homayoun, M | 1 |
| Świąder, MJ | 3 |
| Świąder, K | 2 |
| Zakrocka, I | 1 |
| Krzyżanowski, M | 2 |
| Wróbel, A | 1 |
| Czuczwar, SJ | 46 |
| Sanchez, DL | 1 |
| Fusick, AJ | 1 |
| Gunther, SR | 1 |
| Hernandez, MJ | 1 |
| Sullivan, GA | 1 |
| Catalano, MC | 1 |
| Catalano, G | 1 |
| Kagami, S | 2 |
| Vajda, FJE | 2 |
| O'Brien, TJ | 5 |
| Graham, JE | 2 |
| Hitchcock, AA | 2 |
| Lander, CM | 2 |
| Eadie, MJ | 3 |
| Hamdy, MM | 1 |
| Elfatatry, AM | 1 |
| Mekky, JF | 1 |
| Hamdy, E | 1 |
| Pociecha, J | 1 |
| Reyes, G | 1 |
| Espeche, A | 1 |
| Galichio, S | 1 |
| Fasulo, L | 1 |
| Semprino, M | 1 |
| Greenhalgh, J | 4 |
| Weston, J | 5 |
| Dundar, Y | 2 |
| Nevitt, SJ | 3 |
| Tan, TSE | 1 |
| Sanamandra, SK | 1 |
| Elgarhi, R | 1 |
| Shehata, MM | 1 |
| Abdelsameea, AA | 1 |
| Salem, AE | 1 |
| Peng, A | 1 |
| Lai, W | 1 |
| Li, W | 1 |
| Qiu, X | 1 |
| Zhang, L | 2 |
| He, S | 1 |
| Kondrat-Wróbel, M | 1 |
| Karwan, S | 3 |
| Plewa, Z | 2 |
| Florek-Łuszczki, M | 4 |
| Lu, PL | 1 |
| Hodes, JF | 1 |
| Zheng, X | 1 |
| Hu, XY | 1 |
| Jung, I | 1 |
| Shin, JH | 1 |
| Kim, J | 1 |
| Wang, CY | 1 |
| Jiao, Z | 1 |
| Ding, JJ | 1 |
| Yu, EQ | 1 |
| Zhu, GX | 1 |
| Devries, S | 1 |
| Mulder, M | 1 |
| Charron, JG | 1 |
| Prokop, JW | 1 |
| Mark, PR | 1 |
| Koneval, Z | 1 |
| Knox, KM | 1 |
| Memon, A | 1 |
| Zierath, DK | 1 |
| Barker-Haliski, M | 1 |
| Chen, B | 1 |
| Jin, L | 2 |
| Zhang, W | 1 |
| Yu, L | 2 |
| Feng, J | 1 |
| Yu, Z | 1 |
| Dai, H | 1 |
| Quílez, A | 1 |
| Baraldés-Rovira, M | 1 |
| Gallego, Y | 1 |
| Sanahuja, J | 1 |
| Mauri-Capdevila, G | 1 |
| Purroy, F | 1 |
| Liu, M | 2 |
| Mao, J | 1 |
| Xu, H | 1 |
| Zhao, P | 1 |
| Xu, Q | 1 |
| Du, Z | 1 |
| Drabik, M | 1 |
| Głuszak, M | 1 |
| Wróblewska-Łuczka, P | 2 |
| Jankiewicz, M | 1 |
| Kozińska, J | 2 |
| Plech, T | 2 |
| Gesche, J | 1 |
| Hjalgrim, H | 1 |
| Rubboli, G | 1 |
| Beier, CP | 1 |
| Kumar, R | 2 |
| Sarangi, SC | 2 |
| Ganeshan N, S | 1 |
| Agarwal, A | 1 |
| Kaleekal, T | 2 |
| Borowicz-Reutt, KK | 3 |
| Banach, M | 4 |
| Igwe, SC | 1 |
| Müller, RM | 1 |
| Herziger, B | 1 |
| Jeschke, S | 1 |
| Neininger, MP | 1 |
| Bertsche, T | 1 |
| Bertsche, A | 1 |
| Fletcher, ML | 1 |
| Sarangarm, P | 1 |
| Nash, J | 1 |
| Smolinske, SC | 1 |
| Alunday, RL | 1 |
| Seifert, SA | 1 |
| Warrick, BJ | 1 |
| Wong, YS | 1 |
| Wu, CS | 1 |
| Ong, CT | 1 |
| Rudrabhatla, PK | 1 |
| Er, S | 1 |
| Radhakrishnan, A | 2 |
| Menon, RN | 2 |
| Mermi Dibek, D | 1 |
| Öztura, İ | 1 |
| Baklan, B | 1 |
| Litvinova, SA | 1 |
| Voronina, TA | 1 |
| Kondrakhin, EA | 1 |
| Gaydukov, IO | 1 |
| Davletshin, AI | 1 |
| Vasileva, EV | 1 |
| Kovalev, GI | 1 |
| Garbuz, DG | 1 |
| Devinsky, O | 4 |
| King, L | 1 |
| Schwartz, D | 1 |
| Conway, E | 1 |
| Price, D | 1 |
| Kazmierski, D | 1 |
| Sharma, N | 2 |
| O'Leary, K | 1 |
| Ochieng, P | 1 |
| Banawalikar, N | 1 |
| Adiga, S | 1 |
| Adiga, U | 1 |
| Shenoy, V | 1 |
| Shetty, P | 1 |
| Shetty, S | 1 |
| Sharmila, KP | 1 |
| Walbert, T | 1 |
| Harrison, RA | 1 |
| Schiff, D | 2 |
| Avila, EK | 1 |
| Chen, M | 1 |
| Kandula, P | 1 |
| Lee, JW | 1 |
| Le Rhun, E | 1 |
| Stevens, GHJ | 1 |
| Vogelbaum, MA | 1 |
| Wick, W | 1 |
| Weller, M | 2 |
| Wen, PY | 2 |
| Gerstner, ER | 1 |
| Han, X | 1 |
| Zan, X | 1 |
| Xiong, F | 1 |
| Nie, X | 1 |
| Garg, R | 2 |
| Aggarwal, A | 2 |
| Narang, M | 2 |
| Malhotra, R | 1 |
| Abdelmesih, SK | 1 |
| Elkhateeb, N | 1 |
| Zakaria, M | 1 |
| Girgis, MY | 1 |
| Ouerdiene, A | 1 |
| Messelmani, M | 1 |
| Derbali, H | 1 |
| Mansour, M | 1 |
| Zaouali, J | 1 |
| Mrissa, N | 1 |
| Mrissa, R | 1 |
| Smith, PEM | 1 |
| Muro-García, I | 1 |
| Vieira, A | 1 |
| Vega, L | 1 |
| Pastor, J | 1 |
| de Toledo, M | 1 |
| Hakami, T | 1 |
| Riahi-Zanjani, B | 1 |
| Delirrad, M | 1 |
| Fazeli-Bakhtiyari, R | 1 |
| Sadeghi, M | 1 |
| Zare-Zardini, H | 1 |
| Jafari, A | 1 |
| Ghorani-Azam, A | 1 |
| Pahuja, E | 1 |
| Thirthalli, J | 1 |
| Ibrahim, FA | 1 |
| Andrade, C | 1 |
| Tountopoulou, M | 1 |
| Weschke, B | 1 |
| Kaindl, AM | 1 |
| Ragland, JT | 1 |
| Lee, K | 1 |
| Aicua Rapun, I | 1 |
| Novy, J | 1 |
| Solari, D | 1 |
| Oddo, M | 1 |
| Rossetti, AO | 1 |
| Maldonado, C | 1 |
| Guevara, N | 1 |
| Silveira, A | 1 |
| Fagiolino, P | 1 |
| Vázquez, M | 1 |
| O'Connor, N | 1 |
| Hayden, C | 1 |
| O'Leary, N | 1 |
| Wang, YP | 3 |
| Unger, M | 1 |
| Xiong, G | 1 |
| Sudan, YS | 1 |
| Bansal, AR | 1 |
| Tamburin, S | 1 |
| Faccini, M | 2 |
| Casari, R | 2 |
| Federico, A | 1 |
| Morbioli, L | 1 |
| Franchini, E | 1 |
| Bongiovanni, LG | 2 |
| Lugoboni, F | 2 |
| Ferrara, P | 1 |
| Gatto, A | 1 |
| Blasi, V | 1 |
| DI Ruscio, F | 1 |
| Battaglia, D | 1 |
| Shaaban, AA | 1 |
| El-Agamy, DS | 2 |
| Grundmann, M | 1 |
| Koristkova, B | 1 |
| Brozmanova, H | 1 |
| Kacirova, I | 1 |
| Khedhaier, WBC | 1 |
| Dridi, I | 1 |
| Aouam, K | 1 |
| Ben-Attia, M | 1 |
| Reinberg, A | 1 |
| Boughattas, NA | 1 |
| Oh, JS | 1 |
| Tulasi, J | 1 |
| Xiaodan, R | 1 |
| Stacey, WC | 1 |
| Neumar, RW | 1 |
| Joshi, D | 2 |
| Misra, UK | 1 |
| Dubey, D | 1 |
| Kalita, J | 1 |
| Yu, H | 1 |
| Tang, X | 1 |
| Tang, R | 1 |
| Hamada, NM | 1 |
| Ashour, RH | 1 |
| Shalaby, AA | 1 |
| El-Beltagi, HM | 1 |
| Omar, M | 1 |
| Abdul, R | 1 |
| Panday, A | 1 |
| Teelucksingh, S | 1 |
| Zhang, Z | 1 |
| Wang, Z | 1 |
| Zhang, B | 1 |
| Popławska, M | 1 |
| Xu, L | 1 |
| Guo, D | 1 |
| Liu, YY | 1 |
| Qiao, DD | 1 |
| Ye, JY | 1 |
| Xue, R | 1 |
| Aguiar, GPS | 1 |
| Oliveira, JV | 1 |
| Siebel, AM | 2 |
| Mercadé Cerdá, JM | 1 |
| López Gonzalez, FJ | 1 |
| Serrano Castro, P | 1 |
| Castro Vilanova, MD | 1 |
| Campos Blanco, DM | 1 |
| Querol Pascual, MR | 1 |
| Rivero Rodríguez, D | 1 |
| Scherle Matamoros, C | 1 |
| Dicapua Sacoto, D | 1 |
| Maldonado Samaniego, N | 1 |
| Vargas, R | 1 |
| Beltrán, L | 1 |
| Lizama, R | 1 |
| Valenzuela, GR | 1 |
| Caraballo, R | 2 |
| Li, K | 1 |
| Gu, J | 3 |
| Guo, X | 1 |
| Gao, T | 1 |
| Li, D | 1 |
| Higashida, K | 1 |
| Tanaka, T | 3 |
| Yamagami, H | 1 |
| Tomari, S | 1 |
| Fukuma, K | 1 |
| Okuno, Y | 1 |
| Abe, S | 1 |
| Nagatsuka, K | 1 |
| Toyoda, K | 1 |
| Ihara, M | 1 |
| Feng, W | 3 |
| Mei, S | 3 |
| Zhu, L | 3 |
| Yu, Y | 3 |
| Yang, W | 2 |
| Gao, B | 3 |
| Wu, X | 2 |
| Zhao, Z | 3 |
| Fang, F | 5 |
| Shakir, S | 1 |
| Ali, N | 1 |
| Nazish, H | 1 |
| Zheng, YM | 1 |
| Zhang, JP | 1 |
| Tang, S | 1 |
| Song, DQ | 1 |
| Yong, CH | 1 |
| Vallat, W | 1 |
| Norton, G | 1 |
| Süße, M | 1 |
| Hamann, L | 1 |
| Flöel, A | 1 |
| von Podewils, F | 1 |
| Kim, KH | 1 |
| Song, JS | 1 |
| Park, CW | 1 |
| Ki, CS | 1 |
| Heo, K | 1 |
| Servati, N | 1 |
| Priano, J | 1 |
| Vilar, J | 1 |
| Schiel, J | 1 |
| Jahan, K | 3 |
| Pillai, KK | 6 |
| Vohora, D | 8 |
| Duveau, V | 1 |
| Buhl, DL | 1 |
| Evrard, A | 1 |
| Ruggiero, C | 1 |
| Mandé-Niedergang, B | 1 |
| Roucard, C | 1 |
| Gurrell, R | 1 |
| Ergul Erkec, O | 1 |
| Algul, S | 1 |
| Kara, M | 1 |
| Dimeski, G | 1 |
| Treacy, O | 1 |
| Marshall, G | 1 |
| Gmiro, VE | 3 |
| Serdyuk, SE | 1 |
| Veselkina, OS | 3 |
| Toyama, Y | 1 |
| Kawamata, J | 1 |
| Shimohama, S | 1 |
| Lotfy, DM | 1 |
| Safar, MM | 2 |
| Mohamed, SH | 1 |
| Kenawy, SA | 1 |
| Ogwang, R | 1 |
| Anguzu, R | 1 |
| Akun, P | 1 |
| Ningwa, A | 1 |
| Kayongo, E | 1 |
| Marsh, K | 1 |
| Newton, CRJC | 1 |
| Idro, R | 1 |
| Baudou, E | 1 |
| Benevent, J | 1 |
| Montastruc, JL | 1 |
| Touati, G | 1 |
| Hachon LeCamus, C | 1 |
| Sands, TT | 1 |
| Rahdari, S | 1 |
| Oldham, MS | 1 |
| Caminha Nunes, E | 1 |
| Tilton, N | 1 |
| Cilio, MR | 1 |
| Gearhart, AM | 1 |
| Guardiola, JJ | 1 |
| El-Kersh, K | 1 |
| Sawicka, KM | 2 |
| Wawryniuk, A | 1 |
| Daniluk, J | 2 |
| Chmielewski, J | 1 |
| Li, C | 1 |
| Su, L | 1 |
| Lao, M | 1 |
| Zhu, S | 1 |
| Ding, M | 1 |
| Han, J | 1 |
| Wu, Y | 2 |
| Miller, I | 1 |
| Laux, L | 2 |
| Zolnowska, M | 1 |
| Wright, S | 1 |
| Roberts, C | 1 |
| Romoli, M | 1 |
| Mazzocchetti, P | 1 |
| D'Alonzo, R | 1 |
| Siliquini, S | 1 |
| Rinaldi, VE | 1 |
| Verrotti, A | 3 |
| Calabresi, P | 1 |
| Costa, C | 1 |
| Salas-Puig, X | 1 |
| Iniesta, M | 1 |
| Abraira, L | 1 |
| Puig, J | 1 |
| Arava, S | 1 |
| Yamada-Takeda, M | 1 |
| Patel, A | 2 |
| Fenton, G | 1 |
| Chen, CC | 1 |
| Yeap, MC | 1 |
| Liu, ZH | 1 |
| Hsieh, PC | 1 |
| Chen, CT | 1 |
| Liu, YT | 1 |
| Lee, CY | 1 |
| Lai, HY | 1 |
| Wu, CT | 1 |
| Tu, PH | 1 |
| Lange, F | 1 |
| Weßlau, K | 1 |
| Porath, K | 1 |
| Hörnschemeyer, J | 1 |
| Bergner, C | 1 |
| Krause, BJ | 1 |
| Mullins, CS | 1 |
| Linnebacher, M | 1 |
| Köhling, R | 2 |
| Kirschstein, T | 1 |
| Kessler, SK | 1 |
| McGinnis, E | 1 |
| Kapur, V | 1 |
| D'Cruz, S | 1 |
| Kaur, R | 1 |
| Marzeda, P | 1 |
| Gut-Lepiech, A | 1 |
| Kondrat-Wróbel, MW | 2 |
| Nakashima, T | 2 |
| Koido, K | 1 |
| Nishibuchi, Y | 1 |
| Hashimoto, H | 1 |
| Ito, A | 1 |
| Inamoto, Y | 1 |
| Kurosawa, S | 1 |
| Kim, SW | 1 |
| Terakado, H | 1 |
| Chaudhary, M | 1 |
| Alkhaldi, H | 1 |
| Alhazmi, R | 1 |
| Housawi, Y | 1 |
| Lasek-Bal, A | 1 |
| Lukasik, M | 1 |
| Żak, A | 1 |
| Sulek, A | 1 |
| Bosak, M | 2 |
| Kosaka, T | 1 |
| Ohta, G | 1 |
| Kometani, H | 1 |
| Kawatani, M | 1 |
| Ohshima, Y | 1 |
| Mousavi-Hasanzadeh, M | 1 |
| Rezaeian-Varmaziar, H | 1 |
| Shafaat, O | 1 |
| Jand, A | 1 |
| Palizvan, MR | 1 |
| Wang, MJ | 1 |
| Jiang, L | 2 |
| Chen, HS | 1 |
| Schubert-Bast, S | 1 |
| Wolff, M | 1 |
| Wiemer-Kruel, A | 1 |
| von Spiczak, S | 1 |
| Trollmann, R | 1 |
| Reif, PS | 1 |
| Pritchard, C | 1 |
| Polster, T | 1 |
| Neubauer, BA | 1 |
| Mayer, T | 1 |
| Macdonald, D | 1 |
| Kurlemann, G | 1 |
| Kluger, G | 1 |
| Klein, KM | 1 |
| Kieslich, M | 1 |
| Kay, L | 1 |
| Kalski, M | 1 |
| Irwin, J | 1 |
| Herting, A | 1 |
| Carroll, J | 1 |
| Bettendorf, U | 1 |
| Bast, T | 1 |
| Rosenow, F | 1 |
| Strzelczyk, A | 1 |
| Tseng, AL | 1 |
| Wong, AYJ | 1 |
| McLelland, CJ | 1 |
| Walmsley, SL | 1 |
| Peng, BW | 1 |
| Liang, HC | 1 |
| Li, JL | 1 |
| Yang, SY | 1 |
| Liang, W | 1 |
| Zhang, FQ | 1 |
| Chen, WX | 1 |
| Kwong, AK | 1 |
| Chu, VL | 1 |
| Rodenburg, RJT | 1 |
| Smeitink, J | 1 |
| Fung, CW | 1 |
| Solanki, P | 1 |
| Coppler, PJ | 1 |
| Kvaløy, JT | 1 |
| Baldwin, MA | 1 |
| Callaway, CW | 1 |
| Elmer, J | 1 |
| Johannessen Landmark, C | 1 |
| Fløgstad, I | 1 |
| Syvertsen, M | 1 |
| Baftiu, A | 1 |
| Enger, U | 1 |
| Koht, J | 1 |
| Johannessen, SI | 1 |
| Jin, Q | 1 |
| Fu, Z | 1 |
| Guan, L | 1 |
| Jiang, H | 1 |
| Ito, H | 1 |
| Mori, K | 1 |
| Kohmoto, T | 1 |
| Imoto, I | 1 |
| Imran, I | 1 |
| Koch, K | 1 |
| Schöfer, H | 1 |
| Lau, H | 1 |
| Klein, J | 1 |
| Nolan, SJ | 3 |
| Pulman, J | 3 |
| Wilson, KL | 1 |
| Alexander, JM | 1 |
| Agostinelli, S | 1 |
| Prezioso, G | 1 |
| Coppola, G | 2 |
| Capovilla, G | 1 |
| Romeo, A | 2 |
| Striano, P | 2 |
| Parisi, P | 1 |
| Grosso, S | 2 |
| Spalice, A | 1 |
| Foiadelli, T | 1 |
| Curatolo, P | 2 |
| Chiarelli, F | 1 |
| Savasta, S | 2 |
| Barker, CA | 1 |
| Bishop, AJ | 1 |
| Chang, M | 1 |
| Beal, K | 1 |
| Chan, TA | 1 |
| Kholin, AA | 1 |
| Kerkhof, M | 1 |
| Dielemans, JC | 1 |
| van Breemen, MS | 2 |
| Zwinkels, H | 2 |
| Walchenbach, R | 2 |
| Taphoorn, MJ | 2 |
| Vecht, CJ | 2 |
| Belozertsev, IuA | 1 |
| Zapol'skaia, IuA | 1 |
| Belozertsev, FIu | 1 |
| Iuntsev, SV | 1 |
| Kaufmann, K | 1 |
| Romaine, I | 1 |
| Days, E | 1 |
| Pascual, C | 1 |
| Malik, A | 1 |
| Yang, L | 1 |
| Zou, B | 1 |
| Du, Y | 1 |
| Sliwoski, G | 1 |
| Morrison, RD | 1 |
| Denton, J | 1 |
| Niswender, CM | 1 |
| Daniels, JS | 1 |
| Sulikowski, GA | 1 |
| Xie, XS | 1 |
| Lindsley, CW | 1 |
| Weaver, CD | 1 |
| Karlov, VA | 1 |
| Geĭbatova, LG | 1 |
| Lapenta, L | 1 |
| Vaudano, AE | 1 |
| Gregori, B | 1 |
| Vanacore, N | 1 |
| Mareš, P | 7 |
| Kubová, H | 4 |
| Battino, D | 1 |
| Tomson, T | 2 |
| Bonizzoni, E | 1 |
| Craig, J | 1 |
| Lindhout, D | 1 |
| Sabers, A | 1 |
| Perucca, E | 3 |
| Wirrell, EC | 2 |
| Franz, DN | 1 |
| Sullivan, J | 1 |
| Saneto, RP | 1 |
| Morse, RP | 1 |
| Chugani, H | 1 |
| Hernandez, A | 1 |
| Hamiwka, L | 1 |
| Mikati, MA | 1 |
| Valencia, I | 1 |
| Le Guern, ME | 1 |
| Chancharme, L | 1 |
| de Menezes, MS | 1 |
| Flesler, S | 2 |
| Pasteris, MC | 1 |
| Lopez Avaria, MF | 1 |
| Fortini, S | 1 |
| Vilte, C | 1 |
| Lee, YJ | 1 |
| Kim, T | 1 |
| Bae, SH | 1 |
| Kim, YH | 2 |
| Han, JH | 1 |
| Yun, CH | 1 |
| Kim, CY | 1 |
| Taha, FA | 1 |
| Hammond, DN | 1 |
| Sheth, RD | 1 |
| Howlett, IC | 1 |
| Tanouye, MA | 2 |
| Chen, HF | 1 |
| Xu, LP | 1 |
| Luo, ZY | 1 |
| Yu, ZQ | 1 |
| Li, ZY | 1 |
| Cui, QY | 1 |
| Qin, LM | 1 |
| Ren, YY | 1 |
| Shen, HS | 1 |
| Tang, JQ | 1 |
| Jin, LJ | 1 |
| Zhu, JJ | 1 |
| Wang, KY | 1 |
| Wu, TQ | 1 |
| Wang, ZY | 1 |
| Shekh-Ahmad, T | 3 |
| McDonough, JH | 2 |
| Baraban, SC | 1 |
| Dinday, MT | 1 |
| Hortopan, GA | 1 |
| Fang, Y | 1 |
| Li, H | 1 |
| Liu, W | 1 |
| Lin, S | 1 |
| Fu, M | 1 |
| Cao, X | 1 |
| Elms, J | 1 |
| Powell, KL | 1 |
| van Raay, L | 1 |
| Dedeurwaerdere, S | 1 |
| Morris, MJ | 1 |
| Rigamonti, A | 1 |
| Lauria, G | 1 |
| Grimod, G | 1 |
| Bianchi, G | 1 |
| Salmaggi, A | 1 |
| Zhong, ZD | 1 |
| Li, L | 1 |
| Wu, YH | 1 |
| You, Y | 1 |
| Li, WM | 1 |
| Zou, P | 1 |
| Han, K | 1 |
| Holder, JL | 1 |
| Schaaf, CP | 1 |
| Lu, H | 1 |
| Kang, H | 1 |
| Tang, J | 1 |
| Hao, S | 1 |
| Cheung, SW | 1 |
| Yu, P | 1 |
| Sun, H | 1 |
| Breman, AM | 1 |
| Lu, HC | 1 |
| Zoghbi, HY | 1 |
| Belcastro, V | 1 |
| Abe, K | 2 |
| Hamada, H | 1 |
| Yamada, T | 2 |
| Obata-Yasuoka, M | 1 |
| Minakami, H | 1 |
| Yoshikawa, H | 1 |
| Snehunsu, A | 1 |
| Mukunda, N | 1 |
| Satish Kumar, MC | 1 |
| Sadhana, N | 1 |
| Naduvil Narayanan, S | 1 |
| Vijay Kapgal, K | 1 |
| Avinash, H | 1 |
| Chandrashekar, BR | 1 |
| Raghavendra Rao, K | 1 |
| Nayak, BS | 1 |
| Habib, M | 1 |
| Khan, SU | 1 |
| Hoque, A | 1 |
| Mondal, BA | 1 |
| Hasan, AT | 1 |
| Chowdhury, RN | 1 |
| Haque, B | 1 |
| Rahman, KM | 1 |
| Chowdhury, AH | 1 |
| Ghose, SK | 1 |
| Mohammad, QD | 1 |
| Shah, KH | 1 |
| Shailaja, S | 1 |
| Girisha, KM | 1 |
| Bonnett, LJ | 1 |
| Smith, D | 1 |
| Williamson, PR | 3 |
| Chadwick, D | 2 |
| Fernández Colomer, B | 1 |
| Rekarte García, S | 1 |
| García López, JE | 1 |
| Pérez González, C | 1 |
| Montes Granda, M | 1 |
| Coto Cotallo, GD | 1 |
| Posner, E | 1 |
| Miró, J | 1 |
| Aiguabella, M | 1 |
| Veciana, M | 1 |
| Juvany, R | 1 |
| Santurino, M | 1 |
| Leiva, E | 1 |
| Salas-Puig, J | 1 |
| Falip, M | 1 |
| Felker, D | 1 |
| Lynn, A | 1 |
| Johnson, DE | 1 |
| Serdiuk, SE | 2 |
| Markoula, S | 1 |
| Teotonio, R | 1 |
| Ratnaraj, N | 6 |
| Duncan, JS | 1 |
| Sander, JW | 1 |
| Patsalos, PN | 6 |
| Ishii, W | 1 |
| Fujita, Y | 2 |
| Momoki, E | 1 |
| Imai, Y | 1 |
| Endo, A | 1 |
| Arakawa, C | 1 |
| Kohira, R | 1 |
| Fuchigami, T | 1 |
| Mugishima, H | 1 |
| Stepanova, D | 1 |
| Beran, RG | 1 |
| Tanaka, H | 1 |
| Jotoku, H | 1 |
| Takasaki, M | 1 |
| Ibayashi, Y | 1 |
| Watanabe, K | 2 |
| Takahashi, M | 2 |
| Rheims, S | 1 |
| Ryvlin, P | 1 |
| Raszewski, G | 2 |
| Anwar, MJ | 1 |
| Radhakrishna, KV | 1 |
| Sharma, A | 1 |
| Aksoy, D | 1 |
| Cevik, B | 1 |
| Kurt, S | 1 |
| Pekdas, E | 1 |
| Solmaz, V | 1 |
| Kiani, IG | 1 |
| Qureshi, SH | 1 |
| Shah, F | 1 |
| Bhowmik, M | 1 |
| Saini, N | 1 |
| Berardi, D | 1 |
| Clemente, R | 1 |
| Finn, BC | 1 |
| Bruetman, JE | 1 |
| Young, P | 1 |
| Imataka, G | 1 |
| Arisaka, O | 1 |
| Lovett, M | 1 |
| Skidmore, DL | 1 |
| Mohamed, IS | 1 |
| Huang, DH | 1 |
| Zheng, JO | 1 |
| Shazadi, K | 1 |
| Petrovski, S | 1 |
| Roten, A | 1 |
| Miller, H | 1 |
| Huggins, RM | 1 |
| Brodie, MJ | 3 |
| Pirmohamed, M | 1 |
| Johnson, MR | 1 |
| Sills, GJ | 1 |
| Hanrath, MA | 1 |
| Swart, EL | 1 |
| Tinchon, A | 1 |
| Oberndorfer, S | 1 |
| Marosi, C | 1 |
| Gleiss, A | 1 |
| Geroldinger, A | 1 |
| Sax, C | 1 |
| Sherif, C | 1 |
| Moser, W | 1 |
| Grisold, W | 1 |
| Shihyakugari, A | 1 |
| Miki, A | 1 |
| Nakamoto, N | 1 |
| Satoh, H | 1 |
| Sawada, Y | 1 |
| Kumar, H | 1 |
| Klein, S | 1 |
| Bankstahl, M | 1 |
| Löscher, W | 20 |
| Villalba Martínez, G | 1 |
| Fernández-Candil, JL | 1 |
| Vivanco-Hidalgo, RM | 1 |
| Pacreu Terradas, S | 1 |
| León Jorba, A | 1 |
| Arroyo Pérez, R | 1 |
| Camacho, A | 1 |
| Núñez, N | 1 |
| Dekomien, G | 1 |
| Hernández-Laín, A | 1 |
| de Aragón, AM | 1 |
| Simón, R | 1 |
| Lucey, BP | 1 |
| Leahy, A | 1 |
| Rosas, R | 1 |
| Shaw, PJ | 1 |
| Dressler, A | 1 |
| Trimmel-Schwahofer, P | 1 |
| Reithofer, E | 1 |
| Mühlebner, A | 1 |
| Gröppel, G | 1 |
| Reiter-Fink, E | 1 |
| Benninger, F | 1 |
| Grassl, R | 1 |
| Feucht, M | 1 |
| Galer, S | 1 |
| Urbain, C | 1 |
| De Tiège, X | 1 |
| Emeriau, M | 1 |
| Leproult, R | 1 |
| Deliens, G | 1 |
| Nonclerq, A | 1 |
| Peigneux, P | 1 |
| Van Bogaert, P | 1 |
| Miranda Herrero, MC | 1 |
| Alcaraz Romero, AJ | 1 |
| Escudero Vilaplana, V | 1 |
| Fernández Lafever, SN | 1 |
| Fernández-Llamazares, CM | 1 |
| Barredo Valderrama, E | 1 |
| Vázquez López, M | 1 |
| de Castro, P | 1 |
| Jellett, AP | 1 |
| Jenks, K | 1 |
| Lucas, M | 1 |
| Scott, RC | 1 |
| Zolkowska, D | 2 |
| Prisinzano, TE | 1 |
| Baumann, MH | 1 |
| Luszczki, JJ | 24 |
| James, EJ | 1 |
| Ramirez-Vizcarrondo, CM | 1 |
| Hasan, M | 1 |
| Truszkowski, TL | 1 |
| Tan, Y | 1 |
| Oupravanh, PM | 1 |
| Khakhalin, AS | 1 |
| Aizenman, CD | 1 |
| Kurian, M | 1 |
| Heritier Barras, AC | 1 |
| Korff, CM | 1 |
| Cranley, MR | 1 |
| Craner, M | 1 |
| McGilloway, E | 1 |
| Leclercq, K | 1 |
| Afrikanova, T | 2 |
| Langlois, M | 1 |
| De Prins, A | 1 |
| Buenafe, OE | 1 |
| Rospo, CC | 1 |
| Van Eeckhaut, A | 1 |
| de Witte, PA | 2 |
| Crawford, AD | 2 |
| Smolders, I | 1 |
| Kaminski, RM | 2 |
| Wlodarczyk, BJ | 3 |
| Özdemir, HH | 1 |
| Müngen, B | 1 |
| İlhan, S | 1 |
| Gefroh-Grimes, HA | 1 |
| Gidal, BE | 1 |
| Gavzan, H | 1 |
| Sayyah, M | 1 |
| Sardari, S | 1 |
| Babapour, V | 1 |
| Pyrka, D | 1 |
| Glowniak, K | 2 |
| Florek-Luszczki, M | 2 |
| Glensk, M | 2 |
| Zeng, QY | 1 |
| Fan, TT | 1 |
| Zhu, P | 1 |
| He, RQ | 1 |
| Bao, YX | 1 |
| Zheng, RY | 1 |
| Xu, HQ | 1 |
| Huang, YH | 1 |
| Chi, NF | 1 |
| Kuan, YC | 1 |
| Chan, L | 1 |
| Hu, CJ | 1 |
| Chiou, HY | 1 |
| Chien, LN | 1 |
| Beltrame, A | 1 |
| Venturini, S | 1 |
| Crichiutti, G | 1 |
| Meroni, V | 1 |
| Buonfrate, D | 1 |
| Bassetti, M | 1 |
| Bamford, A | 1 |
| Crowe, BH | 1 |
| Hacohen, Y | 1 |
| Lin, JP | 1 |
| Clarke, A | 1 |
| Tudor-Williams, G | 1 |
| Sancho-Shimizu, V | 1 |
| Vincent, A | 1 |
| Lim, M | 1 |
| Pullaperuma, SP | 1 |
| Rassner, MP | 1 |
| Hebel, JM | 1 |
| Altenmüller, DM | 1 |
| Volz, S | 1 |
| Herrmann, LS | 1 |
| Feuerstein, TJ | 1 |
| Freiman, TM | 1 |
| Lerche, H | 1 |
| Lotay, N | 1 |
| DeRossett, S | 1 |
| Edwards, S | 1 |
| Brandt, C | 2 |
| Watanabe, S | 1 |
| Yamamori, S | 1 |
| Otsuka, S | 1 |
| Saito, M | 1 |
| Suzuki, E | 1 |
| Kataoka, M | 1 |
| Miyaoka, H | 1 |
| Lusardi, TA | 1 |
| Akula, KK | 1 |
| Coffman, SQ | 1 |
| Ruskin, DN | 1 |
| Masino, SA | 1 |
| Boison, D | 1 |
| Kay, HY | 1 |
| Greene, DL | 1 |
| Kang, S | 1 |
| Kosenko, A | 1 |
| Hoshi, N | 1 |
| Redmayne, N | 1 |
| Robertson, S | 1 |
| Kockler, J | 1 |
| Llewelyn, V | 1 |
| Haywood, A | 1 |
| Glass, B | 1 |
| Motwani, N | 1 |
| Afsar, S | 1 |
| Dixit, NS | 1 |
| Trinka, E | 2 |
| Höfler, J | 1 |
| Leitinger, M | 1 |
| Rohracher, A | 1 |
| Kalss, G | 1 |
| Rasgado, LA | 1 |
| Reyes, GC | 1 |
| Díaz, FV | 1 |
| Cook, AM | 3 |
| Zafar, MS | 1 |
| Mathias, S | 1 |
| Stewart, AM | 1 |
| Albuja, AC | 1 |
| Bensalem-Owen, M | 1 |
| Kapoor, S | 1 |
| Baumann, RJ | 3 |
| Piskorska, B | 2 |
| Spasov, AA | 1 |
| Kalitin, KY | 1 |
| Grechko, OY | 1 |
| Anisimova, VA | 1 |
| Knights, M | 1 |
| Thekkekkara, T | 1 |
| Morris, A | 1 |
| Finlay, E | 1 |
| Guan, LP | 1 |
| Liu, BY | 1 |
| Quan, YC | 1 |
| Yang, LY | 1 |
| Zhen, XH | 1 |
| Wang, SH | 1 |
| Zeiler, FA | 1 |
| Sader, N | 1 |
| Gillman, LM | 1 |
| West, M | 1 |
| Karpova, MN | 2 |
| Kuznetsova, LV | 1 |
| Zin'kovskii, KA | 1 |
| Klishina, NV | 1 |
| Bektaş, G | 1 |
| Çalışkan, M | 1 |
| Aydın, A | 1 |
| Pembegül Yıldız, E | 1 |
| Tatlı, B | 1 |
| Aydınlı, N | 1 |
| Özmen, M | 1 |
| Barczyński, B | 1 |
| Tomaszewski, M | 2 |
| Töllner, K | 2 |
| Twele, F | 1 |
| Pourzitaki, C | 1 |
| Tsaousi, G | 1 |
| Apostolidou, E | 1 |
| Karakoulas, K | 1 |
| Kouvelas, D | 1 |
| Amaniti, E | 1 |
| Grande-Martín, A | 1 |
| Pardal-Fernández, JM | 2 |
| Carrascosa-Romero, MC | 1 |
| De Cabo, C | 1 |
| Rudà, R | 1 |
| Pellerino, A | 1 |
| Soffietti, R | 1 |
| Lin, K | 2 |
| Guaranha, M | 1 |
| Wolf, P | 1 |
| Tan, NN | 1 |
| Tang, HL | 1 |
| Lin, GW | 1 |
| Chen, YH | 1 |
| Lu, P | 1 |
| Li, HJ | 1 |
| Gao, MM | 1 |
| Zhao, QH | 1 |
| Yi, YH | 1 |
| Liao, WP | 1 |
| Long, YS | 1 |
| Hamed, SA | 1 |
| Abdellah, MM | 1 |
| Herzog, AG | 1 |
| Mandle, HB | 1 |
| Cahill, KE | 1 |
| Fowler, KM | 1 |
| Hauser, WA | 1 |
| Deepakumari, HN | 1 |
| Jayanna, BK | 1 |
| Revanasiddappa, HD | 1 |
| Veeresh, B | 1 |
| Pontes, JC | 1 |
| Lima, TZ | 1 |
| Queiroz, CM | 1 |
| Cinini, SM | 1 |
| Blanco, MM | 1 |
| Mello, LE | 1 |
| Singh, T | 2 |
| Goel, RK | 2 |
| Chen, BB | 1 |
| Wang, CT | 1 |
| Wang, JX | 1 |
| Bai, J | 1 |
| Wang, B | 1 |
| Zhang, WJ | 1 |
| Deng, YC | 1 |
| Zhao, G | 1 |
| Dang, JX | 1 |
| Jia, SS | 1 |
| Wang, TC | 1 |
| Jia, FY | 1 |
| Liu, YH | 1 |
| Smetana, KS | 1 |
| Bastin, ML | 1 |
| Oyler, DR | 1 |
| Pohlmann-Eden, B | 2 |
| Noack-Rink, M | 1 |
| Ramirez, F | 1 |
| Tofighy, A | 1 |
| Werhahn, KJ | 1 |
| Wild, I | 1 |
| Kim, JW | 1 |
| Seung, H | 1 |
| Kim, KC | 2 |
| Gonzales, ELT | 1 |
| Oh, HA | 1 |
| Yang, SM | 1 |
| Ko, MJ | 1 |
| Han, SH | 2 |
| Banerjee, S | 1 |
| Shin, CY | 2 |
| Al-Shorbagy, MY | 1 |
| Nassar, NN | 1 |
| Wieshmann, UC | 1 |
| Baker, G | 1 |
| Zanzmera, P | 1 |
| Karkare, K | 1 |
| Soni, H | 1 |
| Jagtap, S | 1 |
| Zaluska, K | 1 |
| Żółkowska, D | 1 |
| Deng, XL | 1 |
| Yin, F | 1 |
| Zhang, CL | 1 |
| Ma, YP | 1 |
| He, F | 1 |
| Wu, LW | 1 |
| Hong, S | 1 |
| Taing, KD | 1 |
| Williams, DA | 1 |
| French, CR | 1 |
| Hsieh, MT | 1 |
| Lai, MC | 1 |
| Lin, KM | 1 |
| Huang, CW | 1 |
| Pokorná, P | 1 |
| Hronová, K | 1 |
| Šíma, M | 1 |
| Slanař, O | 1 |
| Klement, P | 1 |
| van den Anker, JN | 1 |
| Tibboel, D | 1 |
| León Ruiz, M | 1 |
| Rodríguez Sarasa, ML | 1 |
| Sanjuán Rodríguez, L | 1 |
| Pérez Nieves, MT | 1 |
| Ibáñez Estéllez, F | 1 |
| Arce Arce, S | 1 |
| García-Albea Ristol, E | 1 |
| Benito-León, J | 1 |
| Sagot-Lerolle, N | 1 |
| Lamine, A | 1 |
| Chaix, ML | 1 |
| Boufassa, F | 1 |
| Aboulker, JP | 1 |
| Costagliola, D | 1 |
| Goujard, C | 1 |
| Pallier, C | 1 |
| Paller, C | 1 |
| Delfraissy, JF | 1 |
| Lambotte, O | 1 |
| Unalp, A | 1 |
| Dirik, E | 1 |
| Kurul, S | 1 |
| Yang, Z | 1 |
| Qin, J | 2 |
| Bao, X | 1 |
| Chang, X | 1 |
| Xiong, H | 1 |
| Nifosì, F | 1 |
| Martinuzzi, A | 1 |
| Toffanin, T | 1 |
| Costanzo, R | 1 |
| Vestri, A | 1 |
| Battaglia, M | 1 |
| Bertagnoni, GE | 1 |
| Lupi, A | 1 |
| Amistà, P | 1 |
| Carollo, C | 1 |
| Perini, G | 1 |
| Kumar, G | 1 |
| Topper, L | 1 |
| Maytal, J | 1 |
| Sood, N | 1 |
| Sahai, AK | 1 |
| Medhi, B | 1 |
| Chakrabarti, A | 2 |
| Sun, MZ | 2 |
| Deckers, CL | 1 |
| Liu, YX | 2 |
| Song, J | 1 |
| Parker, L | 1 |
| Hormozi, L | 1 |
| Wu, JZ | 1 |
| Grisotto, KP | 1 |
| Bruck, I | 1 |
| Antoniuk, SA | 1 |
| Santos, LH | 1 |
| Domínguez-Fuentes, B | 1 |
| García-Gil, D | 1 |
| Romero-Palacios, A | 1 |
| Sánchez-Crespo, JM | 1 |
| García-Arjona, R | 1 |
| Navarro-Navarro, J | 1 |
| Harden, CL | 1 |
| Sethi, NK | 1 |
| Karikas, GA | 2 |
| Schulpis, KH | 2 |
| Bartzeliotou, A | 1 |
| Regoutas, S | 2 |
| Thanopoulou, C | 1 |
| Papaevangelou, V | 1 |
| Giannoulia-Karantana, A | 1 |
| Papassotiriou, I | 2 |
| Fytou-Pallikari, A | 1 |
| Bondarenko, II | 2 |
| Ertam, I | 1 |
| Sezgin, AO | 1 |
| Unal, I | 1 |
| Chou, HF | 1 |
| Yang, RC | 1 |
| Chen, CY | 2 |
| Jong, YJ | 1 |
| Pierre-Louis, SJ | 1 |
| Brannegan, RT | 1 |
| Evans, AT | 1 |
| Leśkiewicz, M | 1 |
| Budziszewska, B | 1 |
| Lasoń, W | 1 |
| Huang, Y | 1 |
| Arora, M | 1 |
| Praharaj, SK | 2 |
| Sinha, VK | 1 |
| Sarkar, S | 1 |
| Ferguson, LP | 1 |
| Dargan, PI | 1 |
| Hood, JL | 1 |
| Tibby, SM | 1 |
| Eberl, W | 1 |
| Budde, U | 1 |
| Bentele, K | 1 |
| Christen, HJ | 1 |
| Knapp, R | 1 |
| Mey, A | 1 |
| Schneppenheim, R | 1 |
| Wojda, E | 1 |
| Cisowski, W | 1 |
| Rijsman, RM | 1 |
| Kocharov, SL | 2 |
| Castro-Gago, M | 2 |
| Gómez-Lado, C | 2 |
| Eirís-Puñal, J | 1 |
| Díaz-Mayo, I | 1 |
| Castiñeiras-Ramos, DE | 2 |
| Ma, MS | 2 |
| Ding, YX | 2 |
| Ying, W | 1 |
| Ding, CH | 2 |
| Zou, LP | 2 |
| Pradhan, A | 1 |
| Jairam, A | 1 |
| Kumar, RS | 1 |
| Srivastava, A | 2 |
| Sreevastava, D | 1 |
| Dutta, A | 1 |
| Arora, S | 1 |
| Bairaria, AK | 1 |
| Bhargava, A | 1 |
| Sylla-Iyarreta Veitía, M | 1 |
| Dumas, F | 1 |
| Morgant, G | 1 |
| Sorenson, JR | 1 |
| Frapart, Y | 1 |
| Tomas, A | 1 |
| Dinis-Oliveira, RJ | 1 |
| Magalhães, T | 1 |
| Carvalho, F | 1 |
| Santos, A | 1 |
| Lenz, RA | 1 |
| Elterman, RD | 1 |
| Robieson, WZ | 1 |
| Vigna, NV | 1 |
| Saltarelli, MD | 1 |
| Dudra-Jastrzebska, M | 1 |
| Andres-Mach, MM | 1 |
| Schurig, V | 1 |
| D'Antuono, M | 1 |
| Ricalzone, S | 1 |
| Gotman, J | 1 |
| Biagini, G | 1 |
| Avoli, M | 1 |
| Tiamkao, S | 1 |
| Sawanyawisuth, K | 1 |
| Hellings, JA | 1 |
| Barth, FX | 1 |
| Logan, M | 1 |
| Cook-Wiens, G | 1 |
| Osorio, I | 1 |
| Reed, RC | 1 |
| de Leon, J | 3 |
| Kiesel, JL | 1 |
| Fleming, MW | 1 |
| Strobl, B | 1 |
| Okada, A | 1 |
| Noyori, H | 1 |
| Fujiwara, M | 1 |
| Fujiwara, A | 1 |
| Watanabe, Y | 2 |
| Takechi, K | 2 |
| Ishikawa, T | 1 |
| Kaida, Y | 1 |
| Akagi, M | 1 |
| Kamei, C | 2 |
| Annapandian, VM | 1 |
| John, GT | 1 |
| Mathew, BS | 1 |
| Fleming, DH | 1 |
| Mula, M | 1 |
| Walterfang, M | 1 |
| Kornberg, A | 1 |
| Adams, S | 1 |
| Fietz, M | 1 |
| Velakoulis, D | 1 |
| Ohno, Y | 1 |
| Ishihara, S | 1 |
| Terada, R | 1 |
| Serikawa, T | 2 |
| Sasa, M | 2 |
| Hirtz, DG | 1 |
| Dlugos, D | 1 |
| Masur, D | 1 |
| Abdallah, DM | 2 |
| Arafa, NM | 1 |
| Abdel-Aziz, MT | 1 |
| Arcieri, S | 1 |
| Messana, T | 1 |
| Signoriello, G | 1 |
| Pascotto, A | 1 |
| Tobin, JK | 1 |
| Golightly, LK | 1 |
| Kick, SD | 1 |
| Jones, MA | 1 |
| Miliauskas, S | 1 |
| Liesiene, V | 1 |
| Zemaitis, M | 1 |
| Sakalauskas, R | 1 |
| Visudtibhan, A | 1 |
| Bhudhisawadi, K | 1 |
| Vaewpanich, J | 1 |
| Chulavatnatol, S | 1 |
| Kaojareon, S | 1 |
| Łukawski, K | 1 |
| Janowska, A | 1 |
| Jakubus, T | 1 |
| Tochman-Gawda, A | 1 |
| Liukkonen, E | 1 |
| Kantola-Sorsa, E | 1 |
| Paetau, R | 1 |
| Gaily, E | 1 |
| Peltola, M | 2 |
| Granström, ML | 1 |
| Ragab, FA | 1 |
| Hassan, GS | 1 |
| Abu Yossef, HA | 1 |
| Yahya, TA | 1 |
| Abd El-Latif, HA | 1 |
| Trojnar, MK | 1 |
| Chabbchoub Ben Abdallah, R | 1 |
| Kammoun, F | 1 |
| Ayedi, M | 1 |
| Trabelsi, L | 1 |
| Ben Salah, M | 1 |
| Ben Hlima, N | 1 |
| Mahfoudh, A | 1 |
| Sathyanarayana Rao, KN | 1 |
| Subbalakshmi, NK | 1 |
| Lee, Y | 1 |
| Kim, D | 1 |
| Lee, H | 1 |
| Lee, CJ | 1 |
| Pérez-Suárez, G | 1 |
| Marrero, D | 1 |
| Rodríguez, R | 1 |
| Delgado, P | 1 |
| Cobo, M | 1 |
| González-Posada, JM | 1 |
| Hernández, D | 1 |
| Kutschenko, A | 1 |
| Nitsche, MA | 1 |
| Sommer, M | 1 |
| Gileles, E | 1 |
| Paulus, W | 1 |
| Liao, FF | 1 |
| Huang, YB | 1 |
| Meng, LL | 1 |
| Chang, YC | 1 |
| Lin, JJ | 1 |
| Wang, HS | 2 |
| Chou, ML | 1 |
| Hung, PC | 1 |
| Hsieh, MY | 1 |
| Sakr, D | 1 |
| Cersósimo, R | 1 |
| Yasuhara, A | 1 |
| Cioczek, JD | 1 |
| Kominek, M | 1 |
| Yacoob, Y | 1 |
| Bhigjee, AI | 1 |
| Moodley, P | 1 |
| Parboosing, R | 1 |
| Stewart, JD | 1 |
| Horvath, R | 1 |
| Baruffini, E | 1 |
| Ferrero, I | 1 |
| Bulst, S | 1 |
| Watkins, PB | 1 |
| Fontana, RJ | 1 |
| Day, CP | 1 |
| Chinnery, PF | 1 |
| Bondareva, IB | 1 |
| Jelliffe, RW | 1 |
| Andreeva, OV | 1 |
| Bondareva, KI | 1 |
| de las Heras, J | 1 |
| Garin, I | 1 |
| de Nanclares, GP | 1 |
| Aguayo, A | 1 |
| Rica, I | 1 |
| Castaño, L | 1 |
| Vela, A | 1 |
| Manyam, SC | 1 |
| Kung, DH | 1 |
| Rhodes, LB | 1 |
| Newmark, ME | 1 |
| Friedman, DE | 1 |
| Post, RM | 5 |
| Weiss, SR | 4 |
| Said, SA | 1 |
| Misiuta-Krzesinska, M | 1 |
| Florek, M | 1 |
| Zhao, R | 1 |
| Weng, CC | 1 |
| Feng, Q | 1 |
| Zhang, XY | 1 |
| Zhu, HY | 1 |
| Ji, YH | 1 |
| Tsuyusaki, Y | 1 |
| Shimbo, H | 1 |
| Wada, T | 2 |
| Iai, M | 1 |
| Tsuji, M | 1 |
| Yamashita, S | 1 |
| Aida, N | 1 |
| Kure, S | 1 |
| Osaka, H | 1 |
| de Maat, MM | 1 |
| van Leeuwen, HJ | 1 |
| Edelbroek, PM | 1 |
| Khanam, R | 1 |
| Pal, SN | 1 |
| Liang, CS | 1 |
| Yang, FW | 1 |
| Chiang, KT | 1 |
| De Reuck, J | 1 |
| Velizarova, R | 1 |
| Gelisse, P | 1 |
| Pageaux, GP | 1 |
| Genton, P | 2 |
| Crespel, A | 1 |
| May, TW | 1 |
| Boor, R | 2 |
| Rambeck, B | 1 |
| Jürgens, U | 1 |
| Korn-Merker, E | 1 |
| Qureshi, AU | 1 |
| Abbas, R | 1 |
| Ahmad, TM | 1 |
| Evans, MD | 1 |
| Shinar, R | 1 |
| Yaari, R | 1 |
| Bos, MJ | 1 |
| de Weerd, AW | 1 |
| Hagebeuk, EE | 1 |
| Dhamija, R | 1 |
| Gavrilova, RH | 1 |
| LaRoche, SM | 1 |
| Shivdat-Nanhoe, R | 1 |
| Muhle, H | 1 |
| Ettle, E | 1 |
| Stephani, U | 1 |
| Siniatchkin, M | 1 |
| Naito, H | 1 |
| Nagae, M | 1 |
| Okahara, S | 1 |
| Maeyama, H | 1 |
| Okada, D | 1 |
| Hagioka, S | 1 |
| Morimoto, N | 1 |
| Eskandari, S | 1 |
| Varshosaz, J | 1 |
| Minaiyan, M | 1 |
| Tabbakhian, M | 1 |
| Yoon, HW | 1 |
| Giraldo, EA | 1 |
| Wijdicks, EF | 1 |
| Gilad, R | 1 |
| Boaz, M | 1 |
| Dabby, R | 1 |
| Sadeh, M | 1 |
| Lampl, Y | 1 |
| Pérez-Gay, L | 1 |
| Otero-Martínez, S | 1 |
| Rodríguez-Segade, S | 2 |
| Mink, S | 1 |
| Muroi, C | 1 |
| Seule, M | 1 |
| Bjeljac, M | 1 |
| Keller, E | 1 |
| Mao, ZN | 1 |
| Gao, ZG | 1 |
| Zhang, GW | 1 |
| Wang, SB | 1 |
| Barcicka-Klosowska, B | 1 |
| Haratym-Maj, A | 1 |
| Das, S | 2 |
| Joardar, S | 2 |
| Chatterjee, R | 2 |
| Guha, G | 2 |
| Hashmi, MA | 1 |
| Hidaka, N | 1 |
| Suemaru, K | 2 |
| Araki, H | 3 |
| Ooi, WW | 1 |
| Wijemanne, S | 1 |
| Thomas, CB | 1 |
| Quezado, M | 1 |
| Brown, CR | 1 |
| Nash, TE | 1 |
| Pessah, N | 1 |
| Sunder, RA | 1 |
| Rai, A | 1 |
| Mittal, H | 1 |
| Nass, RD | 1 |
| Elger, CE | 1 |
| Fink, GR | 1 |
| Burghaus, L | 1 |
| Stepien, KM | 1 |
| Wolf, S | 1 |
| Kaboutari, J | 1 |
| Zendehdel, M | 1 |
| Habibian, S | 1 |
| Azimi, M | 1 |
| Shaker, M | 1 |
| Karimi, B | 1 |
| Hasmi, MA | 1 |
| Noval Menéndez, J | 1 |
| Campoamor, MT | 1 |
| Laborda, B | 1 |
| López-Colina, G | 1 |
| Iimura, Y | 1 |
| Sugano, H | 1 |
| Nakajima, M | 1 |
| Arai, H | 1 |
| Sasidaran, K | 1 |
| Singhi, S | 1 |
| Singhi, P | 1 |
| El-Azab, AS | 1 |
| Eltahir, KE | 1 |
| Alex, AB | 1 |
| Pollock, A | 1 |
| Wilcox, KS | 3 |
| Albiero, A | 1 |
| Quaglio, G | 1 |
| Storti, M | 1 |
| Fiaschi, A | 1 |
| Kamenetsky, Z | 1 |
| Da'as, N | 1 |
| Esayag, Y | 1 |
| Kleinman, Y | 1 |
| Samuels, N | 1 |
| Biberoglu, G | 1 |
| Tumer, L | 1 |
| Hirfanoglu, TL | 1 |
| Ezgu, FS | 1 |
| Hasanoglu, A | 1 |
| Sarangal, V | 1 |
| Malamiri, RA | 1 |
| Ghaempanah, M | 1 |
| Khosroshahi, N | 1 |
| Nikkhah, A | 1 |
| Bavarian, B | 1 |
| Ashrafi, MR | 1 |
| Vedovello, M | 1 |
| Baldacci, F | 1 |
| Nuti, A | 1 |
| Cipriani, G | 1 |
| Ulivi, M | 1 |
| Vergallo, A | 1 |
| Borelli, P | 1 |
| Bagati, D | 1 |
| Mittal, S | 1 |
| Sarcar, M | 1 |
| Kakra, M | 1 |
| Kumar, P | 1 |
| Maciejak, P | 1 |
| Szyndler, J | 1 |
| Turzyńska, D | 1 |
| Sobolewska, A | 1 |
| Płaźnik, A | 1 |
| Pak, T | 1 |
| Bailey, K | 1 |
| Shields, M | 1 |
| Chanda, S | 1 |
| Addis, M | 1 |
| Robertson, BD | 1 |
| Moffett, M | 1 |
| Lumley, LA | 1 |
| Yourick, DL | 1 |
| Birnbaum, AK | 1 |
| Conway, JM | 1 |
| Strege, MA | 1 |
| Leppik, IE | 2 |
| Orellana-Paucar, AM | 1 |
| Serruys, AS | 1 |
| Maes, J | 1 |
| De Borggraeve, W | 1 |
| Alen, J | 1 |
| León-Tamariz, F | 1 |
| Wilches-Arizábala, IM | 1 |
| Fisch, L | 1 |
| Mégevand, P | 1 |
| Badoud, S | 1 |
| Badoud, A | 1 |
| Seeck, M | 1 |
| Burkhard, PR | 1 |
| Rosemergy, I | 1 |
| Bergin, P | 1 |
| Jones, P | 1 |
| Walker, E | 1 |
| El-Azab, MF | 1 |
| Moustafa, YM | 1 |
| Lau, KK | 1 |
| Papneja, K | 1 |
| Kamal, SM | 1 |
| Samia, P | 1 |
| Petersen, R | 1 |
| Walker, KG | 1 |
| Eley, B | 1 |
| Wilmshurst, JM | 1 |
| Pineda, R | 1 |
| Beattie, CE | 1 |
| Hall, CW | 1 |
| Kang, HC | 1 |
| Hu, Q | 1 |
| Liu, XY | 2 |
| Xu, F | 1 |
| Liu, ZG | 1 |
| Zeng, Z | 1 |
| Wang, M | 1 |
| Zhu, SQ | 1 |
| Park, MK | 1 |
| Lim, KS | 1 |
| Kim, TE | 1 |
| Han, HK | 1 |
| Yi, SJ | 1 |
| Shin, KH | 1 |
| Cho, JY | 1 |
| Shin, SG | 1 |
| Jang, IJ | 1 |
| Yu, KS | 1 |
| Yang, ZX | 1 |
| Zhang, YH | 1 |
| Beghi, E | 1 |
| Borowicz, KK | 15 |
| Stępniak, B | 1 |
| Corradini, I | 1 |
| Donzelli, A | 1 |
| Antonucci, F | 1 |
| Welzl, H | 1 |
| Loos, M | 1 |
| Martucci, R | 1 |
| De Astis, S | 1 |
| Pattini, L | 1 |
| Inverardi, F | 1 |
| Wolfer, D | 1 |
| Caleo, M | 1 |
| Bozzi, Y | 1 |
| Verderio, C | 1 |
| Frassoni, C | 1 |
| Braida, D | 1 |
| Clerici, M | 1 |
| Lipp, HP | 1 |
| Sala, M | 1 |
| Matteoli, M | 1 |
| González, C | 1 |
| Villena, R | 1 |
| Kim, P | 1 |
| Park, JH | 1 |
| Kwon, KJ | 1 |
| Kim, HJ | 1 |
| Lee, JM | 1 |
| Kim, HY | 1 |
| Chang, P | 1 |
| Terbach, N | 1 |
| Plant, N | 1 |
| Chen, PE | 1 |
| Williams, RS | 1 |
| Haghighi, M | 1 |
| Bajoghli, H | 1 |
| Bigdelou, G | 1 |
| Jahangard, L | 1 |
| Holsboer-Trachsler, E | 1 |
| Brand, S | 1 |
| Piato, AL | 1 |
| Schaefer, IC | 1 |
| Nery, LR | 1 |
| Bogo, MR | 1 |
| Cordelli, DM | 1 |
| Garavelli, L | 1 |
| Guerra, A | 1 |
| Pellicciari, A | 1 |
| Giordano, L | 1 |
| Bonetti, S | 1 |
| Cecconi, I | 1 |
| Wischmeijer, A | 1 |
| Seri, M | 1 |
| Rosato, S | 1 |
| Gelmini, C | 1 |
| Della Giustina, E | 1 |
| Ferrari, AR | 1 |
| Zanotta, N | 1 |
| Epifanio, R | 1 |
| Grioni, D | 1 |
| Malbora, B | 1 |
| Mammi, I | 1 |
| Mari, F | 1 |
| Buoni, S | 1 |
| Mostardini, R | 1 |
| Pantaleoni, C | 1 |
| Doz, M | 1 |
| Poch-Olivé, ML | 1 |
| Rivieri, F | 1 |
| Sorge, G | 1 |
| Simonte, G | 1 |
| Licata, F | 1 |
| Tarani, L | 1 |
| Terazzi, E | 1 |
| Mazzanti, L | 1 |
| Cerruti Mainardi, P | 1 |
| Boni, A | 1 |
| Faravelli, F | 1 |
| Grasso, M | 1 |
| Bianchi, P | 1 |
| Zollino, M | 1 |
| Franzoni, E | 1 |
| Zadrozniak, M | 1 |
| Swiader, M | 1 |
| Kowalska, A | 1 |
| Kleinrok, Z | 20 |
| Thibault, M | 1 |
| Blume, WT | 1 |
| Saint-Hilaire, JM | 1 |
| Zakhari, R | 1 |
| Sommerville, KW | 2 |
| van Rijn, CM | 1 |
| Wang, Mz | 1 |
| Wang, MF | 1 |
| Cuadrado, A | 2 |
| de las Cuevas, I | 1 |
| Valdizán, EM | 1 |
| Armijo, JA | 3 |
| Kuebler, D | 1 |
| Tanouye, M | 1 |
| Krsek, P | 1 |
| Sebronová, V | 1 |
| Procházka, T | 1 |
| Maulisová, A | 1 |
| Komárek, V | 1 |
| Akman, CI | 1 |
| Goodkin, HP | 1 |
| Rogers, DP | 1 |
| Riviello, JJ | 1 |
| Isoherranen, N | 3 |
| Woodhead, JH | 4 |
| Spiegelstein, O | 2 |
| Blotnik, S | 2 |
| Bennett, GD | 2 |
| Veggiotti, P | 1 |
| Termine, C | 1 |
| Granocchio, E | 1 |
| Bova, S | 1 |
| Papalia, G | 1 |
| Lanzi, G | 1 |
| Privitera, MD | 1 |
| Mattson, RH | 2 |
| Chadwick, DW | 1 |
| Neto, W | 1 |
| Hashimoto, Y | 2 |
| Futagami, K | 1 |
| Kawasaki, H | 1 |
| Gomita, Y | 2 |
| Yu, KT | 1 |
| Mills, S | 1 |
| Thompson, N | 1 |
| Cunanan, C | 1 |
| Amat, G | 1 |
| Merriweather, M | 1 |
| Hirsch, E | 1 |
| Camino, R | 1 |
| Arjona, A | 1 |
| Zhao, LX | 2 |
| Moon, YS | 2 |
| Basnet, A | 2 |
| Park, JG | 2 |
| Kim, EK | 2 |
| Kim, DO | 1 |
| Jeong, TC | 2 |
| Jahng, Y | 2 |
| Choi, J | 2 |
| Lee, ES | 2 |
| Rugino, TA | 1 |
| Janvier, YM | 1 |
| Baunach, JM | 1 |
| Bilat, CA | 1 |
| Kaminow, L | 1 |
| Schimschock, JR | 1 |
| Hammer, AE | 1 |
| Vuong, A | 1 |
| Doughty, J | 1 |
| Baker, GA | 1 |
| Jacoby, A | 1 |
| Lavaud, V | 1 |
| Calderón Guzmán, D | 1 |
| Espitia Vázquez, I | 1 |
| Barragán Mejía, G | 1 |
| Labra Ruiz, N | 1 |
| Rodríguez Pérez, R | 1 |
| Santamaria del Angel, D | 1 |
| Ayala Guerrero, F | 1 |
| Juárez Olguín, H | 1 |
| Affolter, N | 1 |
| Krähenbühl, S | 1 |
| Schlienger, RG | 2 |
| Trapani, G | 1 |
| Cutrignelli, A | 1 |
| Latrofa, A | 1 |
| Franco, M | 1 |
| Serra, M | 1 |
| Pisu, MG | 1 |
| Biggio, G | 1 |
| Liso, G | 1 |
| Jerez-García, P | 1 |
| Onsurbe-Ramírez, I | 1 |
| Marco-Giner, J | 1 |
| Marsden, D | 1 |
| Libretto, SE | 1 |
| Levy, RH | 5 |
| Somerville, E | 1 |
| Coffey, G | 1 |
| Botts, S | 1 |
| Merks, JH | 1 |
| Ceelie, N | 1 |
| Caron, HN | 1 |
| Hennekam, RC | 1 |
| Duncan, R | 1 |
| Cerminara, C | 1 |
| Montanaro, ML | 1 |
| Seri, S | 1 |
| Tochman, AM | 1 |
| Dekundy, A | 1 |
| Turski, WA | 6 |
| Rwiader, M | 1 |
| Drelewska, E | 1 |
| Sirven, JI | 1 |
| Wingerchuk, DM | 1 |
| Drazkowski, JF | 1 |
| Lyons, MK | 1 |
| Zimmerman, RS | 1 |
| Krauss, GL | 1 |
| Arban, R | 1 |
| Maraia, G | 1 |
| Brackenborough, K | 1 |
| Winyard, L | 1 |
| Wilson, A | 1 |
| Gerrard, P | 1 |
| Large, C | 1 |
| Smith, CT | 1 |
| Jedrzejczak, J | 1 |
| Coves-Orts, FJ | 1 |
| Borrás-Blasco, J | 1 |
| Navarro-Ruiz, A | 1 |
| Murcia-López, A | 1 |
| Palacios-Ortega, F | 1 |
| Peters, CN | 1 |
| Panda, S | 1 |
| Radhakrishnan, K | 1 |
| Bai, H | 1 |
| Zhang, SL | 1 |
| Zhang, HS | 1 |
| Ji, JT | 1 |
| Ma, PB | 1 |
| Bai, YW | 1 |
| Zhou, XR | 1 |
| Ding, MB | 1 |
| Lu, XR | 1 |
| Sun, CY | 1 |
| Szot, P | 1 |
| White, SS | 1 |
| Shen, DD | 4 |
| Anderson, GD | 4 |
| Ilhan, A | 1 |
| Gurel, A | 1 |
| Armutcu, F | 1 |
| Kamisli, S | 1 |
| Iraz, M | 1 |
| Coffey, GL | 1 |
| Botts, SR | 1 |
| Schank, JR | 1 |
| Liles, LC | 1 |
| Weinshenker, D | 1 |
| Dua, T | 1 |
| Gomber, S | 1 |
| Mahajan, V | 1 |
| Pedro, VM | 1 |
| Leisman, G | 1 |
| Sato, K | 1 |
| Ueda, Y | 1 |
| Ueno, K | 1 |
| Okamoto, K | 1 |
| Iizuka, H | 1 |
| Katsuda, S | 1 |
| Kang, TC | 2 |
| Kim, DS | 2 |
| Kwak, SE | 2 |
| Kim, JE | 2 |
| Kim, DW | 1 |
| Kang, JH | 1 |
| Won, MH | 1 |
| Kwon, OS | 2 |
| Choi, SY | 2 |
| Clause, D | 1 |
| Decleire, PY | 1 |
| Vanbinst, R | 1 |
| Soyer, A | 1 |
| Hantson, P | 1 |
| Tandon, VR | 1 |
| Gupta, RK | 1 |
| Langheinrich, TC | 1 |
| Chattopadhyay, A | 1 |
| Kuc, S | 1 |
| Reuber, M | 1 |
| Stoner, SC | 1 |
| Lea, JW | 1 |
| Wolf, AL | 1 |
| Berges, AA | 1 |
| Wong, GK | 1 |
| Poon, WS | 1 |
| Lazaropoulou, C | 1 |
| Margeli, A | 1 |
| Tsakiris, S | 1 |
| Ab Rahman, AF | 1 |
| Ibrahim, MI | 1 |
| Ismail, HI | 1 |
| Seng, TB | 1 |
| Mendhekar, DN | 1 |
| Mohamed, M | 1 |
| Kupiec, T | 1 |
| Raj, V | 1 |
| de Araujo Filho, GM | 1 |
| Pascalicchio, TF | 1 |
| Sousa, PS | 1 |
| Yacubian, EM | 1 |
| Horiuchi, M | 1 |
| Kimura, M | 1 |
| Tokumura, M | 1 |
| Hasebe, N | 1 |
| Arai, T | 1 |
| Kikumoto, K | 1 |
| Yoshinaga, H | 1 |
| Oka, M | 1 |
| Ito, M | 1 |
| Endoh, F | 1 |
| Akiyama, T | 1 |
| Ohtsuka, Y | 1 |
| Devi, PU | 1 |
| Uma Devi, P | 1 |
| Zito, JM | 1 |
| Safer, DJ | 1 |
| Gardner, JF | 1 |
| Soeken, K | 1 |
| Ryu, J | 1 |
| Wolf, GK | 1 |
| McClain, CD | 1 |
| Zurakowski, D | 1 |
| Dodson, B | 1 |
| McManus, ML | 1 |
| Steve White, H | 1 |
| Lamb, JG | 2 |
| Pappo, O | 1 |
| Czuczwar, P | 1 |
| Cioczek-Czuczwar, A | 1 |
| Lapatsanis, P | 1 |
| Lapatsanis, D | 1 |
| Kohli, U | 1 |
| Gulati, S | 1 |
| Betrosian, A | 1 |
| Frantzeskaki, F | 1 |
| Ozge, A | 1 |
| Kaleagasi, H | 1 |
| Yalçin Tasmertek, F | 1 |
| Savina, TA | 1 |
| Balashova, OA | 1 |
| Shchipakina, TG | 1 |
| Temkin, NR | 4 |
| Awan, AB | 2 |
| Winn, HR | 3 |
| Winn, RH | 1 |
| Taylor, LM | 1 |
| Farzam, F | 1 |
| Lewis, DA | 1 |
| Kuhn, RJ | 1 |
| Hommet, C | 1 |
| Mondon, K | 1 |
| de Toffol, B | 1 |
| Constans, T | 1 |
| Manent, JB | 1 |
| Jorquera, I | 1 |
| Mazzucchelli, I | 1 |
| Depaulis, A | 1 |
| Ben-Ari, Y | 1 |
| Represa, A | 1 |
| Macphee, GJ | 1 |
| Stewart, DA | 1 |
| Palencia, G | 1 |
| Calderon, A | 1 |
| Sotelo, J | 1 |
| Furmanek-Karwowska, K | 2 |
| Sawicka, K | 1 |
| Jaszczyk, B | 1 |
| Levisohn, PM | 1 |
| Holland, KD | 1 |
| Choi, HC | 1 |
| Song, HK | 1 |
| Kim, YI | 1 |
| Bratton, SL | 1 |
| Chestnut, RM | 1 |
| Ghajar, J | 1 |
| McConnell Hammond, FF | 1 |
| Harris, OA | 1 |
| Hartl, R | 1 |
| Manley, GT | 1 |
| Nemecek, A | 1 |
| Newell, DW | 2 |
| Rosenthal, G | 1 |
| Schouten, J | 1 |
| Shutter, L | 1 |
| Timmons, SD | 1 |
| Ullman, JS | 1 |
| Videtta, W | 1 |
| Wilberger, JE | 1 |
| Wright, DW | 1 |
| Eggers, AE | 1 |
| Kulkarni, S | 1 |
| Hegde, A | 1 |
| Shah, KN | 1 |
| Jessberger, S | 1 |
| Nakashima, K | 1 |
| Clemenson, GD | 1 |
| Mejia, E | 1 |
| Mathews, E | 1 |
| Ure, K | 1 |
| Ogawa, S | 1 |
| Sinton, CM | 1 |
| Gage, FH | 1 |
| Hsieh, J | 1 |
| Malek, R | 1 |
| Morawska, M | 1 |
| Zarczuk, R | 1 |
| Lukasik, D | 1 |
| Lunde, JL | 1 |
| Nelson, RE | 1 |
| Storandt, HF | 1 |
| Hadzić, N | 1 |
| Vara, R | 1 |
| Raiman, J | 1 |
| Mieli-Vergani, G | 1 |
| Wortmann, SB | 1 |
| Reimer, A | 1 |
| Creemers, JW | 1 |
| Mullaart, RA | 1 |
| García-Aparicio, AM | 1 |
| Leal, MA | 1 |
| Platero, M | 1 |
| Beneyto, P | 1 |
| Allan, RW | 1 |
| Wammanda, RD | 1 |
| Peltola, J | 1 |
| Raitanen, J | 1 |
| Keränen, T | 1 |
| Kharazmi, E | 1 |
| Auvinen, A | 1 |
| Lian, XY | 1 |
| Khan, FA | 1 |
| Stringer, JL | 2 |
| Amr, R | 1 |
| Maraqa, L | 1 |
| Choudry, Q | 1 |
| Franklin, MR | 1 |
| Kupferberg, HJ | 3 |
| Schmutz, M | 3 |
| Czernecki, R | 1 |
| Wojtal, K | 1 |
| Jankiewicz, K | 1 |
| Chrościńska-Krawczyk, M | 1 |
| Błaszczyk, B | 1 |
| Khongsombat, O | 1 |
| Watanabe, H | 3 |
| Tantisira, B | 2 |
| Patarapanich, C | 2 |
| Tantisira, MH | 2 |
| Subhash, HS | 1 |
| Heddle, RJ | 1 |
| Schultz, DW | 1 |
| Ring, J | 1 |
| Thompson, CH | 1 |
| Gromov, SA | 1 |
| Lipatova, LV | 1 |
| Vetter, M | 2 |
| Bernasconi, R | 2 |
| Bencze, W | 1 |
| Hauser, K | 1 |
| Klein, M | 3 |
| Martin, P | 2 |
| Mimaki, T | 1 |
| Yabuuchi, H | 1 |
| Laird, H | 1 |
| Yamamura, HI | 1 |
| Kosoĭ, MIu | 1 |
| Wilder, BJ | 5 |
| Bruni, J | 4 |
| Moore, JR | 1 |
| Williams, TH | 1 |
| Talbot, IC | 1 |
| Tanner, MS | 1 |
| Ehlers, CL | 1 |
| Mulbry, LW | 1 |
| Killam, EK | 1 |
| Woody, RC | 2 |
| Snead, OC | 1 |
| Bearden, LJ | 1 |
| Steardo, L | 1 |
| Florio, C | 1 |
| Sorge, F | 1 |
| Steardo, R | 1 |
| Iadarola, MJ | 2 |
| Gale, K | 3 |
| Hammond, EJ | 2 |
| Bichard, AR | 1 |
| Little, HJ | 1 |
| Lazarova, M | 2 |
| Bendotti, C | 2 |
| Samanin, R | 3 |
| Petersen, EN | 1 |
| Cloyd, JC | 2 |
| Kriel, RL | 2 |
| Fischer, JH | 1 |
| Sawchuk, RJ | 1 |
| Eggerth, RM | 1 |
| Chapman, AG | 1 |
| Meldrum, BS | 2 |
| Mendes, E | 2 |
| Karas, BJ | 1 |
| Penry, JK | 2 |
| Asconape, J | 1 |
| Frey, HH | 3 |
| Reiche, R | 2 |
| Schultz, D | 2 |
| Majkowski, J | 1 |
| Kaplan, H | 1 |
| Keane, PE | 1 |
| Simiand, J | 1 |
| Santucci, V | 1 |
| Morre, M | 1 |
| Procopis, PG | 1 |
| Berlin, CM | 1 |
| de la Morena García, E | 1 |
| Borges Domingo, MT | 1 |
| Nau, H | 5 |
| Marescaux, C | 1 |
| Vergnes, M | 1 |
| Perlman, BJ | 1 |
| Goldstein, DB | 2 |
| Baskies, AM | 1 |
| Porter, RJ | 1 |
| Theodore, WH | 2 |
| Ater, SB | 1 |
| Tolman, KG | 1 |
| Madsen, JA | 1 |
| Matsuo, F | 1 |
| Mancall, EL | 1 |
| Covington, TR | 1 |
| Alonso, RJ | 1 |
| Healy, MA | 2 |
| Aslam, M | 2 |
| Harrison, PG | 1 |
| Fernando, NP | 1 |
| McCown, TJ | 1 |
| Greenwood, RS | 1 |
| Frye, GD | 1 |
| Breese, GR | 1 |
| Chambon, JP | 1 |
| Molimard, JC | 1 |
| Calassi, R | 1 |
| Maruani, J | 1 |
| Rodier, D | 1 |
| Sigault, G | 1 |
| Leyris, R | 1 |
| Roncucci, R | 1 |
| Bizière, K | 1 |
| Toth, E | 1 |
| Lajtha, A | 1 |
| Ciesielski, L | 3 |
| Simler, S | 3 |
| Mandel, P | 4 |
| Maresová, D | 3 |
| Schickerová, R | 1 |
| Koch-Weser, J | 1 |
| Browne, TR | 1 |
| Salt, TE | 1 |
| Tulloch, IF | 2 |
| Walter, DS | 2 |
| Wallace, SJ | 1 |
| Smith, JA | 1 |
| Jeavons, PM | 1 |
| Bonkowsky, HL | 1 |
| Sinclair, PR | 1 |
| Emery, S | 1 |
| Sinclair, JF | 1 |
| Ngwane, E | 1 |
| Bower, B | 1 |
| Cowen, J | 1 |
| Harris, F | 1 |
| Tift, JP | 1 |
| Dalens, B | 1 |
| Raynaud, EJ | 1 |
| Gaulme, J | 1 |
| Nistico, G | 1 |
| De Sarro, GB | 2 |
| Rotiroti, D | 1 |
| Silvestri, R | 1 |
| Marmo, E | 1 |
| Pearce, JL | 1 |
| Giles, HM | 1 |
| Addy, DP | 3 |
| Tartara, A | 1 |
| Moglia, A | 1 |
| Verri, AP | 1 |
| Savoldi, F | 1 |
| Bo, P | 1 |
| Epstein, M | 1 |
| Gonzalez-Pardo, L | 1 |
| Ross, SM | 1 |
| Craig, CR | 1 |
| Johnston, MV | 1 |
| Freeman, JM | 2 |
| Rodin, EA | 1 |
| DeSousa, G | 1 |
| Haidukewych, D | 1 |
| Lodhi, R | 1 |
| Berchou, RC | 1 |
| Lambie, DG | 1 |
| Johnson, RH | 1 |
| Vijayasenan, ME | 1 |
| Whiteside, EA | 1 |
| Albertson, TE | 2 |
| Peterson, SL | 1 |
| Stark, LG | 1 |
| Baselt, RC | 1 |
| Aminoff, MJ | 1 |
| Wolf, B | 1 |
| Paulsen, EP | 1 |
| Turski, L | 1 |
| Turski, W | 2 |
| Bustamante, L | 1 |
| Lueders, H | 2 |
| Pippenger, C | 2 |
| Goldensohn, ES | 2 |
| Rawat, S | 1 |
| Borkowski, WJ | 1 |
| Swick, HM | 1 |
| Fuller, TA | 1 |
| Olney, JW | 1 |
| Tollefson, GD | 1 |
| MacDougall, LG | 1 |
| Nielsen, CJ | 2 |
| Christensen, TL | 2 |
| Lund, M | 1 |
| Gulmann, NC | 1 |
| Schreiber, RA | 1 |
| Yagi, K | 1 |
| Morikawa, T | 1 |
| Miyakoshi, M | 1 |
| Kakegawa, N | 1 |
| Osawa, T | 1 |
| Seino, M | 1 |
| Beckman, DL | 1 |
| Crittenden, DJ | 1 |
| Valiente, R | 1 |
| Herranz, JL | 1 |
| Jursíková, D | 1 |
| Vajda, FJ | 2 |
| Chambers, BR | 1 |
| Hoffman, LM | 1 |
| Clifford, DB | 1 |
| Lothman, EW | 1 |
| Dodson, WE | 1 |
| Ferrendelli, JA | 1 |
| Gever, LN | 1 |
| Shenoy, AK | 1 |
| Miyahara, JT | 1 |
| Patel, CC | 1 |
| Church, S | 1 |
| Reilly, KM | 1 |
| Howe, GM | 1 |
| Howe, SJ | 1 |
| Smith, DB | 1 |
| Carl, GF | 1 |
| Murphy, JV | 1 |
| Marquardt, K | 1 |
| Keys, PA | 1 |
| McCandless, DW | 3 |
| Schwartzenburg, FC | 2 |
| Abel, MS | 1 |
| Lockard, JS | 3 |
| DuCharme, LL | 2 |
| Congdon, WC | 2 |
| Irvine-Meek, JM | 1 |
| Hall, KW | 1 |
| Otten, NH | 1 |
| Leroux, M | 1 |
| Budnik, D | 1 |
| Seshia, SS | 1 |
| Rundfeldt, C | 2 |
| Koch, R | 1 |
| Richter, A | 1 |
| Mevissen, M | 1 |
| Gerecke, U | 1 |
| Miguil, M | 1 |
| Chlihi, A | 1 |
| Mjahed, K | 1 |
| Sarf, I | 1 |
| Moutawakkil, S | 1 |
| Benaguida, M | 1 |
| Tobias, JD | 1 |
| Capers, C | 1 |
| Sims, P | 1 |
| Holcomb, GW | 1 |
| Hönack, D | 6 |
| Adkison, KD | 1 |
| Ojemann, GA | 2 |
| Rapport, RL | 2 |
| Dills, RL | 2 |
| Hanaya, R | 1 |
| Ujihara, H | 1 |
| Amano, T | 2 |
| Matsubayashi, H | 1 |
| Uozumi, T | 1 |
| Longo, LP | 1 |
| Salzman, C | 1 |
| Feldstein, JH | 1 |
| Curtis, JL | 1 |
| Sayin, U | 1 |
| Timmerman, W | 1 |
| Westerink, BH | 1 |
| Nieto Barrera, M | 1 |
| Rufo Campos, M | 1 |
| Silieström Ribed, ML | 1 |
| Evans, RJ | 1 |
| Miranda, RN | 1 |
| Jordan, J | 1 |
| Krolikowski, FJ | 1 |
| Becker, A | 2 |
| Grecksch, G | 2 |
| Piönnigs, B | 1 |
| Ostner, C | 1 |
| Biggs, CS | 1 |
| Pearce, BR | 1 |
| Fowler, LJ | 1 |
| Whitton, PS | 1 |
| Obeid, T | 1 |
| Brichard, B | 1 |
| Vermylen, C | 1 |
| Scheiff, JM | 1 |
| Ninane, J | 1 |
| Cornu, G | 1 |
| Pohl, M | 1 |
| Zelízko, M | 1 |
| Kryzhanovskiĭ, GN | 2 |
| Abrosimov, IIu | 1 |
| Adesioye, S | 1 |
| Ayuk, PB | 1 |
| John, D | 1 |
| Kodwin, P | 1 |
| Maxwell-Irving, T | 1 |
| Kando, JC | 1 |
| Tohen, M | 2 |
| Castillo, J | 1 |
| Centorrino, F | 1 |
| Meltzer, HY | 1 |
| Ranjan, R | 1 |
| Czechowska, G | 1 |
| Dziki, M | 6 |
| Pietrasiewicz, T | 1 |
| Pisani, F | 1 |
| Di Perri, R | 1 |
| Richens, A | 1 |
| Kulkarni, C | 2 |
| David, J | 4 |
| Joseph, T | 4 |
| Talwar, D | 1 |
| Steinhoff, BJ | 1 |
| Stodieck, SR | 1 |
| de Romanis, F | 1 |
| Sopranzi, N | 1 |
| Borowicz, K | 2 |
| Kozicka, M | 2 |
| Sohn, E | 1 |
| Berger, A | 1 |
| Lewis, R | 1 |
| Ono, K | 1 |
| Baba, H | 1 |
| Sugai, S | 1 |
| Yoshida, K | 2 |
| Moriwaka, F | 1 |
| Matsuura, T | 1 |
| Hamada, T | 1 |
| Tashiro, K | 1 |
| Elmazar, MM | 2 |
| Hauck, RS | 2 |
| Sharony, R | 1 |
| Garber, A | 1 |
| Viskochil, D | 1 |
| Schreck, R | 1 |
| Platt, LD | 1 |
| Ward, R | 1 |
| Buehler, BA | 1 |
| Graham, JM | 1 |
| Nakagawa, Y | 1 |
| Takeuchi, H | 1 |
| Kubota, A | 1 |
| Natsume, H | 1 |
| Nasuda, K | 1 |
| Endoh, A | 1 |
| Toya, K | 1 |
| Ogawa, H | 1 |
| Igarashi, Y | 2 |
| Gunatilake, SB | 1 |
| Ruiz-Falcó Rojas, ML | 1 |
| Gutiérrez-Solana, LG | 1 |
| Arias Alvarez, MA | 1 |
| Barrio Nicolás, A | 1 |
| López-Terradas Covisa, JM | 1 |
| Chugh, Y | 1 |
| Sharma, PL | 1 |
| Brosz, M | 1 |
| Gasior, M | 4 |
| Buszewicz, G | 1 |
| Hennessy, MJ | 1 |
| Wiles, CM | 1 |
| Kitano, Y | 1 |
| Usui, C | 1 |
| Takasuna, K | 1 |
| Hirohashi, M | 1 |
| Nomura, M | 1 |
| Fukuda, Y | 1 |
| Ohtomo, Y | 1 |
| Yabuta, K | 1 |
| Fernández, MC | 1 |
| Walter, FG | 1 |
| Petersen, LR | 1 |
| Walkotte, SM | 1 |
| Nava, F | 1 |
| Aguglia, U | 1 |
| Puzantian, T | 1 |
| Reid, KH | 1 |
| Young, C | 1 |
| Schurr, A | 1 |
| Tseng, M | 1 |
| Payne, RS | 1 |
| Keelen, P | 1 |
| Miller, J | 1 |
| Iyer, V | 1 |
| Rowley, HL | 1 |
| Marsden, CA | 1 |
| Martin, KF | 1 |
| Glantz, MJ | 1 |
| Cole, BF | 1 |
| Friedberg, MH | 1 |
| Lathi, E | 1 |
| Choy, H | 1 |
| Furie, K | 1 |
| Akerley, W | 1 |
| Wahlberg, L | 1 |
| Lekos, A | 1 |
| Louis, S | 1 |
| Tober, C | 1 |
| Rostock, A | 1 |
| Bartsch, R | 1 |
| Van Wouwe, JP | 1 |
| Bourgeois, B | 1 |
| McConnell, H | 1 |
| Snyder, PJ | 2 |
| Duffy, JD | 1 |
| Weilburg, J | 1 |
| Valeriano, J | 1 |
| Brillman, J | 1 |
| Cress, K | 1 |
| Cavalier, J | 1 |
| Brudniak, T | 1 |
| Levin, TL | 1 |
| Berdon, WE | 1 |
| Seigle, RR | 1 |
| Nash, MA | 1 |
| Kelley, MT | 1 |
| Walson, PD | 1 |
| Cox, S | 1 |
| Dusci, LJ | 1 |
| DeToledo, JC | 1 |
| Haddad, H | 1 |
| Ramsay, RE | 1 |
| Crider, AM | 1 |
| Kliem, MA | 1 |
| Steinmiller, CL | 1 |
| Seo, TH | 1 |
| Ho, B | 1 |
| Venkatarangan, P | 1 |
| el-Assadi, AA | 1 |
| Burns, CM | 1 |
| Tietz, EI | 1 |
| Andersen, PH | 1 |
| Klitgaard, H | 2 |
| Morton, LD | 1 |
| Rizkallah, E | 1 |
| Pellock, JM | 2 |
| Vriend, JP | 1 |
| Alexiuk, NA | 1 |
| Zarate, CA | 1 |
| Baraibar, G | 1 |
| Chaney, SF | 1 |
| Hurst, G | 1 |
| Petty, MA | 1 |
| Zobrist, R | 1 |
| Holden, KR | 1 |
| Clarke, SL | 1 |
| Griesemer, DA | 1 |
| Selby, R | 1 |
| Nisbet-Brown, E | 1 |
| Basran, RK | 1 |
| Chang, L | 1 |
| Olivieri, NF | 1 |
| Sooksawate, T | 1 |
| Chunngam, T | 1 |
| Bechar, E | 1 |
| Astroug, H | 1 |
| Vadney, VJ | 1 |
| Kraushaar, KW | 1 |
| Dasgupta, A | 1 |
| McLemore, JL | 1 |
| Adams, CA | 1 |
| Joseph, S | 2 |
| Balakrishnan, S | 2 |
| Pandhi, P | 2 |
| Bhargava, VK | 2 |
| Voskuyl, RA | 2 |
| Vreugdenhil, M | 1 |
| Kang, JX | 1 |
| Leaf, A | 1 |
| Lucena, MI | 1 |
| Blanco, E | 1 |
| Corrales, MA | 1 |
| Berthier, ML | 1 |
| Boothe, DM | 1 |
| Sundqvist, A | 1 |
| Lundkvist, B | 1 |
| Starownik, R | 1 |
| Krupp, E | 2 |
| Parada-turska, J | 1 |
| Matagne, A | 1 |
| Kent, L | 1 |
| Blake, A | 1 |
| Whitehouse, W | 1 |
| Jacob, PC | 1 |
| Chand, RP | 1 |
| Ichikawa, H | 1 |
| Kawabata, K | 1 |
| Kushiro, M | 1 |
| Wada, J | 1 |
| Nagake, Y | 1 |
| Makino, H | 1 |
| Abdel-Hafez, AA | 1 |
| Meselhy, MR | 1 |
| Nakamura, N | 1 |
| Hattori, M | 1 |
| Mohamed, TA | 1 |
| Mahfouz, NM | 1 |
| el-Gendy, MA | 1 |
| Oh, PI | 1 |
| Knowles, SR | 1 |
| Shear, NH | 1 |
| Lin, Y | 1 |
| Itomi, K | 1 |
| Takada, H | 1 |
| Kuboda, T | 1 |
| Okumura, A | 1 |
| Aso, K | 1 |
| Negoro, T | 1 |
| Stecker, MM | 1 |
| Kita, M | 1 |
| Fischer, W | 1 |
| van der Goot, H | 1 |
| Onofrj, M | 1 |
| Thomas, A | 1 |
| Paci, C | 1 |
| Della Paschoa, OE | 1 |
| Kruk, MR | 1 |
| Hamstra, R | 1 |
| Danhof, M | 1 |
| Klonowski, P | 1 |
| Gustavson, LE | 1 |
| Boellner, SW | 1 |
| Witt, GF | 1 |
| Guenther, HJ | 1 |
| Granneman, GR | 1 |
| Sarkisian, MR | 1 |
| Rattan, S | 1 |
| D'Mello, SR | 1 |
| LoTurco, JJ | 1 |
| Malhotra, J | 1 |
| Hovinga, CA | 1 |
| Chicella, MF | 1 |
| Rose, DF | 1 |
| Eades, SK | 1 |
| Dalton, JT | 1 |
| Phelps, SJ | 1 |
| Hanson, GR | 1 |
| Jensen, M | 1 |
| Johnson, M | 1 |
| Dikmen, SS | 1 |
| Wilensky, AJ | 1 |
| Holmes, MD | 1 |
| Cohen, W | 1 |
| Nelson, P | 1 |
| Awan, A | 1 |
| Grech, V | 1 |
| Vella, C | 1 |
| Kábová, R | 1 |
| Liptáková, S | 1 |
| Slamberová, R | 1 |
| Pometlová, M | 1 |
| Velísek, L | 2 |
| Jennings, HR | 1 |
| Romanelli, F | 1 |
| Fiedler, M | 1 |
| Sharief, N | 1 |
| Adams, T | 1 |
| Butler, L | 1 |
| Gnanaratnam, J | 1 |
| Sawaki, K | 1 |
| Ohno, K | 1 |
| Miyamoto, K | 1 |
| Hirai, S | 1 |
| Yazaki, K | 1 |
| Kawaguchi, M | 1 |
| Heynen, T | 1 |
| Li, XL | 1 |
| Ungard, JT | 1 |
| Beekman, M | 1 |
| Carter, RB | 1 |
| Witkin, JM | 1 |
| Ishizawa, K | 1 |
| Chen, Z | 1 |
| Okuma, C | 1 |
| Sugimoto, Y | 1 |
| Fujii, Y | 1 |
| Reddy, DS | 1 |
| Rogawski, MA | 1 |
| Solomon, GE | 1 |
| Bhushan, M | 1 |
| Brooke, R | 1 |
| Hewitt-Symonds, M | 1 |
| Craven, NM | 1 |
| August, PJ | 1 |
| Takhar, J | 1 |
| Bishop, J | 1 |
| Ha, JH | 1 |
| Lee, DU | 1 |
| Lee, JT | 1 |
| Kim, JS | 1 |
| Yong, CS | 1 |
| Kim, JA | 1 |
| Ha, JS | 1 |
| Huh, K | 1 |
| Limdi, NA | 1 |
| Faught, E | 1 |
| Gruppo, R | 1 |
| Degrauw, A | 1 |
| Fogelson, H | 1 |
| Glauser, T | 1 |
| Balasa, V | 1 |
| Gartside, P | 1 |
| Illig, AM | 1 |
| Melia, K | 1 |
| Badura, LL | 1 |
| Alfonso, I | 1 |
| Alvarez, LA | 1 |
| Gilman, J | 1 |
| Dunoyer, C | 1 |
| Yelin, K | 1 |
| Papazian, O | 1 |
| Cooper, MA | 1 |
| Groll, A | 1 |
| Bauer, J | 1 |
| Vandevoorde, S | 1 |
| Diependaele, G | 1 |
| Govaerts, SJ | 1 |
| Robert, AR | 1 |
| Wasserman, M | 1 |
| Papo, N | 1 |
| Wolf, J | 1 |
| Niedermaier, N | 1 |
| Bergner, R | 1 |
| Lowitzsch, K | 1 |
| Yamada, K | 1 |
| Aoyagi, Y | 1 |
| Ohta, A | 1 |
| Chatterjie, N | 1 |
| Alexander, G | 1 |
| Wang, H | 1 |
| Bough, KJ | 1 |
| Eagles, DA | 1 |
| Aithala, G | 1 |
| Sztriha, L | 1 |
| Rudenko, AIu | 1 |
| Konoplianko, TV | 1 |
| Stetsiuk, RA | 1 |
| Zhou, D | 1 |
| Hopp, P | 1 |
| Kerling, F | 1 |
| Kirchner, A | 1 |
| Pauli, E | 1 |
| Stefan, H | 1 |
| Łuszczki, J | 1 |
| Arent, K | 1 |
| Wielosz, M | 1 |
| Sanford, MG | 1 |
| Ryan, C | 1 |
| Cummings, AD | 1 |
| Hunt, A | 1 |
| Hackes, B | 1 |
| Shahar, E | 1 |
| Andraus, J | 1 |
| Sagie-Lerman, T | 1 |
| Savitzki, D | 1 |
| Lange, H | 1 |
| Camfield, PR | 1 |
| Bagnell, P | 1 |
| Camfield, CS | 1 |
| Tibbles, JA | 1 |
| Pellegrini, A | 1 |
| Gloor, P | 1 |
| Sherwin, AL | 1 |
| Briant, RH | 1 |
| Foote, SE | 1 |
| Wallis, WE | 1 |
| Watson, B | 1 |
| Jaeken, J | 1 |
| van Goethem, C | 1 |
| Casaer, P | 1 |
| Devlieger, H | 1 |
| Eggermont, E | 1 |
| Pilet, M | 1 |
| Nowack, WJ | 1 |
| Johnson, RN | 1 |
| Hanna, GR | 1 |
| Joanny, P | 1 |
| Eymard, P | 1 |
| Lacolle, JY | 1 |
| Ferrandes, B | 1 |
| Corriol, J | 1 |
| Feussner, GK | 1 |
| Lust, WD | 1 |
| Passonneau, JV | 1 |
| Leviel, V | 1 |
| Naquet, R | 1 |
| Massimo, L | 1 |
| Pasino, M | 1 |
| Rosanda Vadalá, C | 1 |
| Tonini, GP | 1 |
| Perutelli, P | 1 |
| Saccomani, L | 1 |
| Stone, WE | 1 |
| Julien, RM | 1 |
| Fowler, GW | 1 |
| Sato, M | 1 |
| Nagao, T | 1 |
| Ohshimo, T | 1 |
| Wake, A | 1 |
| Tomoda, T | 1 |
| Otsuki, S | 1 |
| Harel, D | 1 |
| Raday-Bitterman, N | 1 |
| Kerem, D | 1 |
| Bustamante, LA | 1 |
| Cole, AP | 1 |
| Schechter, PJ | 1 |
| Tranier, Y | 1 |
| Grove, J | 1 |
| Farinotti, R | 1 |
| Pfaff, MC | 1 |
| Mahuzier, G | 1 |
| Rowan, AJ | 2 |
| Binnie, CD | 2 |
| Warfield, CA | 1 |
| Meinardi, H | 2 |
| Meijer, JW | 2 |
| Vining, EP | 1 |
| Botsford, E | 1 |
| van Allen, M | 1 |
| Williams, AJ | 1 |
| Evans-Jones, LG | 1 |
| Kindley, AD | 1 |
| Groom, PJ | 1 |
| Rosenberry, KR | 1 |
| Korberly, BH | 1 |
| Graziani, LJ | 1 |
| Johnson, DD | 1 |
| Davis, HL | 1 |
| Crawford, RD | 1 |
| Rose, D | 1 |
| de Beer-Pawlikowski, NK | 1 |
| Goedhart, DM | 1 |
| Gutter, T | 1 |
| van der Geest, P | 1 |
| Deisenhammer, E | 1 |
| Sommer, R | 1 |
| Maitre, M | 1 |
| Mack, G | 1 |
| Kempf, E | 1 |
| Ito, T | 1 |
| Hori, M | 1 |
| Shimizu, M | 1 |
| Patel, IH | 2 |
| Lai, AA | 1 |
| Wada, JA | 1 |
| Anlezark, G | 1 |
| Horton, RW | 1 |
| Meldrium, BS | 1 |
| Sawaya, CB | 1 |
| Noble, EP | 1 |
| Gillies, R | 1 |
| Vigran, R | 1 |
| Emson, PC | 1 |
| Simon, D | 1 |
| Elazar, Z | 1 |
| Gottesfeld, Z | 1 |
| Hillbom, ME | 1 |
| Chandra, B | 1 |
| Reutens, DC | 1 |
| Berkovic, SF | 1 |
| Peichev, L | 2 |
| Nistico', G | 1 |
| Urbańska, E | 2 |
| Mori, N | 1 |
| Ohta, S | 1 |
| Churchyard, A | 1 |
| Khangure, M | 1 |
| Grainger, K | 1 |
| Parada, J | 1 |
| Cavalheiro, EA | 1 |
| Murakami, K | 1 |
| Sugimoto, T | 1 |
| Nishida, N | 1 |
| Kobayashi, Y | 1 |
| Kuhara, T | 1 |
| Matsumoto, I | 1 |
| Kane, RE | 1 |
| Kotagel, S | 1 |
| Bacon, BR | 2 |
| Vogler, CA | 1 |
| Ikonen, E | 1 |
| Salo, A | 1 |
| Somer, M | 1 |
| Somer, H | 1 |
| Pääkkönen, L | 1 |
| Peltonen, L | 1 |
| Mana, MJ | 1 |
| Kim, CK | 1 |
| Pinel, JP | 1 |
| Friel, PN | 1 |
| Honeycutt, D | 1 |
| Callahan, K | 1 |
| Rutledge, L | 1 |
| Evans, B | 1 |
| Tseng, CC | 1 |
| Derlet, RW | 1 |
| Georgiev, VP | 1 |
| Lazarova, MB | 1 |
| Kambourova, TS | 1 |
| Jackson, HC | 1 |
| Ripley, TL | 1 |
| Dickinson, SL | 1 |
| Nutt, DJ | 1 |
| Wieser, HG | 1 |
| Agrawal, P | 1 |
| Gustaw, J | 1 |
| Scott, DA | 1 |
| Gholson, CF | 1 |
| Netchvolodoff, CV | 1 |
| Ray, M | 1 |
| Gonzalez, E | 1 |
| McKee, PJ | 1 |
| McGinn, G | 1 |
| Larkin, JG | 1 |
| Palea, KM | 1 |
| Hug, G | 1 |
| McGraw, CA | 1 |
| Bates, SR | 1 |
| Landrigan, EA | 1 |
| Tetzlaff, JE | 1 |
| Kamitani, T | 1 |
| Takegoshi, K | 1 |
| Okuda, K | 1 |
| Okada, E | 1 |
| Sharma, SK | 3 |
| Selvamurthy, W | 3 |
| Maheshwari, MC | 3 |
| Singh, TP | 2 |
| Altshuler, LL | 1 |
| Theodore, W | 1 |
| Scheyer, RD | 1 |
| Cramer, JA | 1 |
| Toftness, BR | 1 |
| Hochholzer, JM | 1 |
| Sánchez Romero, A | 1 |
| Onsurbe Ramírez, I | 1 |
| Appleton, RE | 1 |
| Farrell, K | 3 |
| Applegarth, DA | 2 |
| Dimmick, JE | 1 |
| Wong, LT | 1 |
| Davidson, AG | 1 |
| Szczepanik, B | 1 |
| Wamil, A | 2 |
| Janusz, W | 2 |
| Behari, M | 2 |
| Kassahun, K | 1 |
| Zheng, JJ | 1 |
| Abbott, F | 1 |
| Badalian, LO | 1 |
| Berestov, AI | 1 |
| Blokhin, BM | 1 |
| Lidzhieva, RTs | 1 |
| Il'chuk, IT | 1 |
| Małek, U | 1 |
| Veerman, MW | 1 |
| Macdonald, RL | 2 |
| McLean, MJ | 2 |
| Skerritt, JH | 1 |
| Matsumura, S | 1 |
| Shima, T | 1 |
| Okada, Y | 1 |
| Nishida, M | 1 |
| Okita, S | 1 |
| Kitayama, K | 1 |
| Funaoka, T | 1 |
| Saxon, AJ | 1 |
| Whittaker, S | 1 |
| Hawker, CS | 1 |
| de la Peña, CA | 1 |
| Tutor, JC | 1 |
| Paz, JM | 1 |
| Fernandez, MP | 1 |
| Rozas, I | 1 |
| Del Río, R | 1 |
| Baulac, M | 1 |
| Smadja, D | 1 |
| Cabrol, A | 1 |
| Cabrol, C | 1 |
| LaPlane, D | 1 |
| Ortová, M | 1 |
| Velísková, J | 1 |
| Ohdo, S | 1 |
| Nakano, S | 1 |
| Ogawa, N | 1 |
| Pugh, CB | 1 |
| Garnett, WR | 1 |
| Herranz Fernández, JL | 1 |
| Armijo Simón, JA | 1 |
| Arteaga Manjón-Cabeza, R | 1 |
| Maresová, S | 1 |
| Chepurnov, SA | 1 |
| Chepurnova, NE | 1 |
| Artiukhova, MV | 1 |
| Kuznetsova, EIu | 1 |
| Nezavibat'ko, VN | 1 |
| Pallini, R | 1 |
| Palestini, M | 1 |
| Lauretti, L | 1 |
| Rossi, GF | 1 |
| Sugaya, E | 1 |
| Ishige, A | 1 |
| Sekiguchi, K | 1 |
| Iizuka, S | 1 |
| Sakamoto, K | 1 |
| Matsuzaki, Y | 1 |
| Aburada, M | 1 |
| Hosoya, E | 1 |
| Kruse, HJ | 2 |
| Kuch, H | 2 |
| Higuchi, T | 1 |
| Yamazaki, O | 1 |
| Takazawa, A | 1 |
| Kato, N | 1 |
| Watanabe, N | 1 |
| Minatogawa, Y | 1 |
| Yamazaki, J | 1 |
| Ohshima, H | 1 |
| Nagaki, S | 1 |
| Kent, AP | 1 |
| Webster, RA | 2 |
| Shandra, AA | 1 |
| Vezzani, A | 1 |
| Wu, HQ | 1 |
| Tullii, M | 1 |
| Sklenovský, A | 1 |
| Chmela, Z | 1 |
| Dewhurst, DG | 1 |
| Vellucci, SV | 1 |
| Kishita, C | 1 |
| Cornford, EM | 1 |
| Oldendorf, WH | 1 |
| Sobrian, SK | 1 |
| Nandedkar, AK | 1 |
| Orr, JM | 1 |
| Jan, JE | 1 |
| Wong, PK | 1 |
| Rosenberg, HK | 1 |
| Ortega, W | 1 |
| Schwarz, SS | 1 |
| Freed, WJ | 1 |
| Lundberg, B | 1 |
| Nergårdh, A | 1 |
| Ritzén, EM | 1 |
| Samuelsson, K | 1 |
| Vamvakidès, A | 1 |
| Kolokouris, N | 1 |
| Dean, C | 1 |
| Hauswald, M | 1 |
| MacDonald, JT | 1 |
| Young, NA | 1 |
| Lewis, SJ | 1 |
| Harris, QL | 1 |
| Jarrott, B | 1 |
| Ambrosetto, G | 1 |
| Tassinari, CA | 1 |
| Gal, P | 1 |
| Oles, KS | 1 |
| Gilman, JT | 1 |
| Weaver, R | 1 |
| Laney, SM | 1 |
| Fisher, JE | 1 |
| Bourgeois, BF | 1 |
| Griffith, WH | 1 |
| Taylor, L | 1 |
| Hess, CW | 1 |
| Kuhnz, W | 1 |
| Piredda, SG | 1 |
| Garden, AS | 1 |
| Benzie, RJ | 1 |
| Hutton, EM | 1 |
| Gare, DJ | 1 |
| Millington, DS | 1 |
| Bohan, TP | 1 |
| Roe, CR | 1 |
| Yergey, AL | 1 |
| Liberato, DJ | 1 |
| Pollack, GM | 1 |
| Alvarez, N | 1 |
| Dailey, JW | 1 |
| Jobe, PC | 1 |
| Portet, C | 1 |
| Maître, L | 1 |
| Jones, RS | 1 |
| Baltzer, V | 1 |
| Fröscher, W | 1 |
| Burr, W | 1 |
| Penin, H | 1 |
| Vohl, J | 1 |
| Bülau, P | 1 |
| Kreiten, K | 1 |
| Taylor, SM | 1 |
| Abbott, LC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Multicenter, Randomized, Blinded, Comparative Effectiveness Study of Fosphenytoin, Valproic Acid, or Levetiracetam in the Emergency Department Treatment of Patients With Benzodiazepine-refractory Status Epilepticus.[NCT01960075] | Phase 3 | 478 participants (Actual) | Interventional | 2015-10-31 | Completed | ||
| Study on Glioma Patients: Understanding Their Glioma Clinical Trial Experiences[NCT05958472] | 500 participants (Anticipated) | Observational | 2024-08-31 | Not yet recruiting | |||
| Effect of Adding Lamotrigine to Sodium Valproate in Childhood Epilepsy: Clinicolabratory Study[NCT05881928] | Phase 4 | 50 participants (Anticipated) | Interventional | 2023-07-25 | Not yet recruiting | ||
| Fenfluramine in CKDL5 Deficiency Disorder (CDD)[NCT03861871] | Phase 2 | 7 participants (Actual) | Interventional | 2019-10-29 | Completed | ||
| PSG in Valproate-induced Nocturnal Enuresis in Children[NCT04191863] | 260 participants (Actual) | Observational | 2018-09-01 | Completed | |||
| The Prospective Trial for Validation of the Role of Levetiracetam as a Sensitizer of Temozolomide in the Treatment of Newly Diagnosed Glioblastoma Patients[NCT02815410] | Phase 2 | 73 participants (Anticipated) | Interventional | 2016-07-31 | Not yet recruiting | ||
| The BrainDrugs-Epilepsy Study: A Prospective Open-label Cohort Precision Medicine Study in Epilepsy[NCT05450822] | 550 participants (Anticipated) | Observational | 2022-02-18 | Recruiting | |||
| Investigating the Effect of Closed-loop Auditory Stimulation on Sleep and Behavior in Patients With Epilepsy and Healthy Controls: a Developmental Study[NCT04716673] | 120 participants (Anticipated) | Interventional | 2020-07-29 | Recruiting | |||
| Does Short-Term Anti-Seizure Prophylaxis After Traumatic Brain Injury Decrease Seizure Rates?[NCT03054285] | Phase 4 | 2,300 participants (Anticipated) | Interventional | 2017-07-01 | Recruiting | ||
| Effect of Melatonin on Seizure Outcome, Neuronal Damage and Quality of Life in Patients With Generalized Epilepsy: A Randomized, add-on Placebo-controlled Clinical Trial[NCT03590197] | Phase 4 | 104 participants (Actual) | Interventional | 2018-08-06 | Completed | ||
| The Study of Pharmacokinetics of Levetiracetam in Patients Undergoing Intermittent Hemodialysis[NCT04511676] | 12 participants (Actual) | Observational | 2018-11-01 | Completed | |||
| A Therapeutic Confirmatory, Open-label, Multi-center, Randomized 2 Parallel Groups, Community-based Trial Studying the Efficacy and Safety of Levetiracetam (1000 to 3000 mg/Day Oral Tablets 250-500 mg b.i.d.) Compared to Sodium Valproate (1000 to 2000 mg/[NCT00175903] | Phase 3 | 1,701 participants (Actual) | Interventional | 2005-02-28 | Completed | ||
| IGHID 11424 - A Pilot Trial of the Effect of Vorinostat and AGS-004 on Persistent HIV-1 Infection (The VOR VAX Study)[NCT02707900] | Phase 1 | 6 participants (Actual) | Interventional | 2016-03-31 | Terminated (stopped due to Manufacturing of the AGS-004 HIV vaccine by Argos could no longer be provided.) | ||
| Childhood Absence Epilepsy Rx PK-PD-Pharmacogenetics Study[NCT00088452] | Phase 3 | 453 participants (Actual) | Interventional | 2004-07-31 | Completed | ||
| Pilot Study of Seizure Prophylaxis With Levetiracetam in Aneurysmal Subarachnoid Hemorrhage[NCT01935908] | Phase 4 | 0 participants (Actual) | Interventional | 2013-05-31 | Withdrawn (stopped due to no funding) | ||
| Clinical, Laboratory and Imaging Features, Treatment Trends and Long Term Outcomes in Patients With Parenchymal and Extraparenchymal Neurocysticercosis-A Registry Based Study[NCT04706819] | 1,000 participants (Anticipated) | Observational [Patient Registry] | 2021-01-15 | Not yet recruiting | |||
| Pharmacotoxicology of Trichloroethylene Metabolites: Short-term Effect of DCA on in Vivo Tyrosine Catabolism and MAAI Expression[NCT00865514] | 2 participants (Actual) | Interventional | 2011-08-31 | Terminated (stopped due to Difficulty in obtaining the solution from the compounding pharmacies caused a two year delay in start-up; the funding ended prior to study completion.) | |||
| Valproic Acid-associated Hypoalbuminemia in Medically Fragile Pediatric and Young Adult Patients in a Long Term Care Facility Part 1: Potential Mechanism for Decreased Albumin Synthesis[NCT00723762] | 90 participants (Anticipated) | Observational | 2009-02-28 | Completed | |||
| Effect of the Treatment of Vitamin D Deficiency in Drug-resistant Epilepsy[NCT03475225] | Phase 3 | 400 participants (Anticipated) | Interventional | 2018-04-30 | Not yet recruiting | ||
| In Vivo Study of Safety, Tolerability and Dosing Effect on SMN mRNA and Protein Levels of Valproic Acid in Patients With Spinal Muscular Atrophy[NCT00374075] | Phase 1 | 42 participants | Interventional | 2003-09-30 | Completed | ||
| Phase I/II Trial of Valproic Acid and Carnitine in Infants With Spinal Muscular Atrophy Type I (CARNI-VAL Type I)[NCT00661453] | Phase 1/Phase 2 | 40 participants (Actual) | Interventional | 2008-04-30 | Completed | ||
| Multi-center Phase II Trial of Valproic Acid and Carnitine in Patients With Spinal Muscular Atrophy (SMA CARNI-VAL Trial)[NCT00227266] | Phase 2 | 94 participants (Actual) | Interventional | 2005-09-30 | Completed | ||
| Monitoring of Seizures, EEG and Serum Antiepileptic Drug Concentrations in Patients With Uncontrolled Epilepsy[NCT00001149] | 900 participants | Observational | 1975-11-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Length of hospital stay in days (NCT01960075)
Timeframe: length of hospital stay
| Intervention | days (Median) |
|---|---|
| Fosphenytoin (FOS) | 3 |
| Valproic Acid | 3 |
| Levetiracetam | 3 |
Length of stay is determined by the number of calendar days after the day of ED arrival until hospital discharge or subject end-of-study. (NCT01960075)
Timeframe: number of calendar days after the day of ED arrival until hospital discharge or subject end-of-study
| Intervention | days (Median) |
|---|---|
| Fosphenytoin (FOS) | 1 |
| Valproic Acid | 1 |
| Levetiracetam | 1 |
The time to termination of seizures is the interval from the start of study drug infusion to cessation of clinically apparent seizure in those who meet the primary outcome. (NCT01960075)
Timeframe: start of drug infusion to seizure cessation
| Intervention | minutes (Median) |
|---|---|
| Fosphenytoin (FOS) | 11.7 |
| Valproic Acid | 7.0 |
| Levetiracetam | 10.5 |
ICU admission is recorded as occurring only if the ICU is the initial inpatient unit for the patient. (NCT01960075)
Timeframe: Admission to intensive care unit after start of study drug infusion, where the ICU is the initial inpatient unit for the patient
| Intervention | Participants (Count of Participants) |
|---|---|
| Fosphenytoin (FOS) | 70 |
| Valproic Acid | 71 |
| Levetiracetam | 87 |
Determined by the absence of clinically apparent seizures and improving consciousness at 1 hour without other anticonvulsant medications. The Adjudicated outcomes analysis is different from Outcome measure 1 because a central clinical phenomenology core of four neurologists adjudicated from the medical records the time to seizure cessation, the time in status epilepticus before trial-drug initiation, and the cause of the seizure. For each enrollment, two neurologists from this core group conducted independent initial reviews and then determined a consensus or consulted a third adjudicator, as needed. Adjudicators were unaware of the treatment assignments and made determinations by medical record review. (NCT01960075)
Timeframe: Within 60 minutes after the start of study drug infusion
| Intervention | Participants (Count of Participants) |
|---|---|
| Fosphenytoin (FOS) | 57 |
| Valproic Acid | 60 |
| Levetiracetam | 67 |
Determined by the absence of clinically apparent seizures and improving consciousness at 1 hour without other anticonvulsant medications. Intention to treat (NCT01960075)
Timeframe: Within 60 minutes after the start of study drug infusion
| Intervention | Participants (Count of Participants) |
|---|---|
| Fosphenytoin (FOS) | 53 |
| Valproic Acid | 56 |
| Levetiracetam | 68 |
Determined by the absence of clinically apparent seizures and improving consciousness at 1 hour without other anticonvulsant medications. Per-protocol analysis (NCT01960075)
Timeframe: Within 60 minutes after the start of study drug infusion
| Intervention | Participants (Count of Participants) |
|---|---|
| Fosphenytoin (FOS) | 37 |
| Valproic Acid | 43 |
| Levetiracetam | 51 |
Acute anaphylaxis is defined as a clinical presentation consistent with life threatening allergic reaction occurring within 6 hours of the start of study drug infusions and manifested as urticaria in combination with either (1) a systolic blood pressure of < 90 mmHg sustained for greater than 5 minutes, or (2) objective evidence of airway obstruction, and for which the patient was treated with antihistamines and/or steroids. (NCT01960075)
Timeframe: within 6 hours of the start of study drug infusions
| Intervention | Participants (Count of Participants) |
|---|---|
| Fosphenytoin (FOS) | 0 |
| Valproic Acid | 0 |
| Levetiracetam | 0 |
Respiratory depression is defined as impairment of ventilation or oxygenation necessitating definitive endotracheal intubation and mechanical ventilation. It is distinct from intubations performed only for airway protection in those with decreased levels of consciousness. It does not include those getting only supraglottic airways or transient bag-valve-mask support. (NCT01960075)
Timeframe: 24 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Fosphenytoin (FOS) | 16 |
| Valproic Acid | 10 |
| Levetiracetam | 12 |
acute seizure recurrence 60 minutes to 12 hours after start of study drug infusion (NCT01960075)
Timeframe: 60 minutes to 12 hours after start of study drug infusion
| Intervention | Participants (Count of Participants) |
|---|---|
| Fosphenytoin (FOS) | 14 |
| Valproic Acid | 14 |
| Levetiracetam | 16 |
Safety outcome: Death (NCT01960075)
Timeframe: 30 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Fosphenytoin (FOS) | 3 |
| Valproic Acid | 2 |
| Levetiracetam | 7 |
Endotracheal intubation within 60 minutes of start of study drug infusion (NCT01960075)
Timeframe: within 60 minutes of start of study drug infusion
| Intervention | Participants (Count of Participants) |
|---|---|
| Fosphenytoin (FOS) | 33 |
| Valproic Acid | 21 |
| Levetiracetam | 30 |
Safety outcome: Hepatic transaminase or ammonia elevations (NCT01960075)
Timeframe: 24 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Fosphenytoin (FOS) | 0 |
| Valproic Acid | 1 |
| Levetiracetam | 1 |
Life-threatening hypotension within 60 minutes of the start of study drug infusion (NCT01960075)
Timeframe: within 60 minutes of the start of study drug infusion
| Intervention | Participants (Count of Participants) |
|---|---|
| Fosphenytoin (FOS) | 4 |
| Valproic Acid | 2 |
| Levetiracetam | 1 |
Life-threatening cardiac arrhythmia within 60 minutes of the start of study drug infusion (NCT01960075)
Timeframe: within 60 minutes of the start of study drug infusion
| Intervention | Participants (Count of Participants) |
|---|---|
| Fosphenytoin (FOS) | 0 |
| Valproic Acid | 0 |
| Levetiracetam | 1 |
Purple glove syndrome is defined as the presence of all three of the findings of the objective edema: discoloration, and pain in the distal extremity in which study drug was administered, with or without known extravasation, and for which there is no other evident etiology. (NCT01960075)
Timeframe: 24 hours
| Intervention | Participants (Count of Participants) |
|---|---|
| Fosphenytoin (FOS) | 0 |
| Valproic Acid | 0 |
| Levetiracetam | 0 |
Number of participants with seizure cessation within 20 minutes of study drug initiation for patients with treatment success. This outcome measure was only reported in the Supplementary materials to the Primary Paper. (NCT01960075)
Timeframe: within 20 minutes
| Intervention | Participants (Count of Participants) |
|---|---|
| Fosphenytoin (FOS) | 43 |
| Valproic Acid | 43 |
| Levetiracetam | 53 |
Change between baseline and Week 14 in the median number of monthly convulsive seizures. (NCT03861871)
Timeframe: Baseline, Week 14
| Intervention | Number of monthly seizures (Median) |
|---|---|
| Fenfluramine Hydrochloride | 88.429 |
The CGIC is a 1-item, parent/caregiver-completed assessment used determine how much their child/care-recipient has improved with treatment. The instrument asks parents/caregivers to rate their child's/care-recipient's improvement as: 1) very much improved; 2) much improved; 3) minimally improved; 4) unchanged; 5) a little worse; 6) much worse; 7) very much worse; the total score correspondingly ranges from 1-7. (NCT03861871)
Timeframe: Baseline, Week 14
| Intervention | score on a scale (Mean) |
|---|---|
| Fenfluramine Hydrochloride | -2.429 |
The IGIC is a 1-item, investigator-completed assessment used determine how much a patient has improved with treatment. The instrument asks the investigator to rate patients' improvement as: 1) very much improved; 2) much improved; 3) minimally improved; 4) unchanged; 5) a little worse; 6) much worse; 7) very much worse; the total score correspondingly ranges from 1-7. (NCT03861871)
Timeframe: Baseline, Week 14
| Intervention | score on a scale (Mean) |
|---|---|
| Fenfluramine Hydrochloride | 1.571 |
The PedsQL Epilepsy Module is a 29-item measure with five scales: Impact, Cognitive, Sleep, Executive Function, and Mood/Behavior. The Impact scale (nine items) assesses how epilepsy interferes with daily activities, interacting with peers, independence, and increased disease burden due to treatment. The Cognitive Scale (six items) assesses memory, ability to learn new materials, school-related difficulties, and reading difficulties. The Sleep Scale (three items) assesses fatigue and sleep difficulties. The Executive Function Scale (six items) assesses organization, task initiation, impulsivity, and inattention. The Mood/Behavior Scale (five items) assesses feelings of anger, sadness, worries, and frustration tolerance. Scores range from 0-100 for each subscale, with higher scores representing better quality of life. The raw score is the sum of each subscale score and ranges from 0-500. (NCT03861871)
Timeframe: Baseline, Week 14
| Intervention | score on a scale (Mean) |
|---|---|
| Fenfluramine Hydrochloride | -103.571 |
Parent/caregiver-completed assessment assessing how epilepsy affects day-to-day functioning of their child/care-recipient in various life areas. Each item is ranked on a 5-point Likert scale from 1 (response correlated with the lowest possible quality of life) to 5 (response correlated with the highest possible quality of life). Item scores are then transformed to a 0-100 scale as follows: 1 = 0, 2 = 25, 3 = 50, 4=75, and 5=100. The total score is the average of all item scores and ranges from 0-100. Higher scores indicate greater quality of life; an increase in scores indicates quality of life increased during the observational period. (NCT03861871)
Timeframe: Baseline, Week 14
| Intervention | score on a scale (Mean) |
|---|---|
| Fenfluramine Hydrochloride | -0.429 |
A Confidence Index of 0.60 or higher on the Conners' Continuous Performance Test at the visit at 16 or 20 weeks or at an earlier visit when treatment was discontinued (as long as the discontinuation occurred 1 month or more after the baseline visit and was not due to intolerable adverse events). A Confidence Index of 0.60 corresponds to a 60% probability that the child has clinical attention deficit disorder. (NCT00088452)
Timeframe: First 16-20 weeks of double blind therapy
| Intervention | Participants (Count of Participants) |
|---|---|
| Ethosuximide | 35 |
| Lamotrigine | 25 |
| Valproic Acid | 52 |
Treatment failure was defined as persistence of absence seizures at 12 months of double blind therapy, a generalized tonic-clonic seizure at any time, excessive drug-related systemic toxicity, a moderately severe rash (possibly drug-related), pancreatitis, or increase in the body-mass index of at least 3.0 from baseline, dose-limiting toxicity after a single downward dose modification, or withdrawal initiated by the parent or physician. (NCT00088452)
Timeframe: First 12 months of double blind therapy
| Intervention | Participants (Count of Participants) |
|---|---|
| Ethosuximide | 70 |
| Lamotrigine | 31 |
| Valproic Acid | 64 |
Treatment failure was defined as persistence of absence seizures at week 16 or week 20, a generalized tonic-clonic seizure at any time, excessive drug-related systemic toxicity, a moderately severe rash (possibly drug-related), pancreatitis, or increase in the body-mass index of at least 3.0 from baseline, dose-limiting toxicity after a single downward dose modification, or withdrawal initiated by the parent or physician. (NCT00088452)
Timeframe: First 16-20 weeks of double blind therapy
| Intervention | Participants (Count of Participants) |
|---|---|
| Ethosuximide | 81 |
| Lamotrigine | 43 |
| Valproic Acid | 85 |
(NCT00661453)
Timeframe: -2 weeks, time 0, 3 months, 6 months
| Intervention | g (Mean) | |||||
|---|---|---|---|---|---|---|
| Lean Mass Baseline | Lean Mass 3 months | Lean Mass 6 months | Fat Mass Baseline | Fat Mass 3 months | Fat Mass 6 months | |
| SMA Type 1 | 4317.15 | 4993.92 | 5133.83 | 3011.37 | 3618.25 | 4316.08 |
The maximum Compound Motor Action Potential (CMAP) is a measurement obtained through EMG testing that is associated with disease progression. In this study, we measure the maximum CMAP by stimulating one nerve in the hand and measuring the response of the muscle. This is done multiple times, the outcome used is the highest peak, or response observed. (NCT00227266)
Timeframe: 1 month prior to official enrollment, beginning of study (0 months), 6 months, 12 months (data point not available)
| Intervention | mV (Mean) | |
|---|---|---|
| Baseline | 6 months | |
| Cohort 1a Sitters Placebo Then Treatment | 2.28 | 2.32 |
| Cohort 1b Sitters Treatment | 2.93 | 2.37 |
| Cohort 2 Standers and Walkers - Treatment | 5.52 | 6.56 |
The maximum Compound Motor Action Potential (CMAP) is a measurement obtained through EMG testing that is associated with disease progression. In this study, we measure the maximum CMAP by stimulating one nerve in the hand and measuring the response of the muscle. This is done multiple times, the outcome used is the highest peak, or response observed. (NCT00227266)
Timeframe: 1 month prior to official enrollment, beginning of study (0 months), 6 months, 12 months (data point not available)
| Intervention | mV (Median) | |
|---|---|---|
| Baseline | 6 months | |
| Cohort 1a Sitters Placebo Then Treatment | 1.91 | 1.44 |
| Cohort 1b Sitters Treatment | 2.2 | 1.8 |
| Cohort 2 Standers and Walkers - Treatment | 5.3 | 5.85 |
The maximum Compound Motor Action Potential (CMAP) area is a measurement obtained through EMG testing that is associated with disease progression. In this study, we measure the maximum CMAP by stimulating one nerve in the hand and measuring the response of the muscle. This procedure is repeated multiple times. The maximum area is the response that results in the largest area under the response curve. (NCT00227266)
Timeframe: 1 month prior to official enrollment, beginning of study (0 months), 6 months, 12 months (data point not available)
| Intervention | mVms (Mean) | |
|---|---|---|
| Baseline | 6 months | |
| Cohort 1a Sitters Placebo Then Treatment | 5.46 | 5.28 |
| Cohort 1b Sitters Treatment | 5.45 | 5.26 |
| Cohort 2 Standers and Walkers - Treatment | 14.85 | 16.26 |
The maximum Compound Motor Action Potential (CMAP) area is a measurement obtained through EMG testing that is associated with disease progression. In this study, we measure the maximum CMAP by stimulating one nerve in the hand and measuring the response of the muscle. This procedure is repeated multiple times. The maximum area is the response that results in the largest area under the response curve. (NCT00227266)
Timeframe: 1 month prior to official enrollment, beginning of study (0 months), 6 months, 12 months (data point not available)
| Intervention | mVms (Median) | |
|---|---|---|
| Baseline | 6 months | |
| Cohort 1a Sitters Placebo Then Treatment | 3.6 | 3.74 |
| Cohort 1b Sitters Treatment | 4.6 | 3.4 |
| Cohort 2 Standers and Walkers - Treatment | 13.65 | 16.85 |
Comparison of Modified Hammersmith Change from baseline to 6 months. Scores range from 0 to 40. A higher score indicates a better outcome. This scale is used to assess gross motor abilities of non-ambulant children with SMA in multiple research trials as well as in clinical settings. (NCT00227266)
Timeframe: 0 months, 6 months
| Intervention | Score (Mean) | ||
|---|---|---|---|
| Baseline visit (0 weeks) | 6 Month visit (V2) | Change from Baseline | |
| Cohort 1a Sitters Placebo Then Treatment | 20.0 | 20.6 | 0.6 |
| Cohort 1b Sitters Treatment | 16.6 | 16.8 | 0.2 |
"Baseline Modified Hammersmith Extend testing. The baseline test is the score they receive during their screening visits. This scale ranges from 0 to 56. A higher score indicates a better outcome.~This scale is used to assess gross motor abilities of children with SMA in multiple research trials as well as in clinical settings." (NCT00227266)
Timeframe: 1 month prior to enrollment, at enrollment (0 months)
| Intervention | Score (Mean) | |
|---|---|---|
| Modified Hammersmith Extend at S1 (-4 weeks) | Modified Hammersmith Extend at S2 (0 weeks) | |
| Cohort 2 Experimental | 47.0 | 48.3 |
98 reviews available for valproic acid and Seizures
| Article | Year |
|---|---|
Synthetic and therapeutic perspectives of nitrogen containing heterocycles as anti-convulsants.
Topics: Animals; Anticonvulsants; Heterocyclic Compounds; Humans; Molecular Structure; Seizures; Structure-A | 2020 |
Topiramate for juvenile myoclonic epilepsy.
Topics: Anticonvulsants; Humans; Myoclonic Epilepsy, Juvenile; Randomized Controlled Trials as Topic; Seizur | 2021 |
A systematic review of the efficacy of perampanel as treatment for myoclonic seizures and symptomatic myoclonus
Topics: Anticonvulsants; Epilepsies, Myoclonic; Epilepsy, Generalized; Humans; Immunoglobulin E; Levetiracet | 2022 |
Management of epilepsy in brain tumor patients.
Topics: Anticonvulsants; Benzodiazepines; Brain Neoplasms; Epilepsy; Humans; Isocitrate Dehydrogenase; Lacos | 2022 |
The interplay of epilepsy with impaired mitophagy and autophagy linked dementia (MAD): A review of therapeutic approaches.
Topics: Anticonvulsants; Carbamazepine; Dementia; Epilepsy; Felbamate; Gabapentin; Humans; Inflammasomes; La | 2022 |
Treatment of benzodiazepine-resistant status epilepticus: Systematic review and network meta-analyses.
Topics: Adult; Anticonvulsants; Benzodiazepines; Child; Drug Resistance; Humans; Levetiracetam; Network Meta | 2022 |
[Paediatric status epilepticus].
Topics: Adult; Anesthetics; Anticonvulsants; Benzodiazepines; Child; Epilepsy; Humans; Ketamine; Lacosamide; | 2022 |
[Medical Treatment of Epilepsy].
Topics: Anticonvulsants; Epilepsy; Female; Humans; Lamotrigine; Levetiracetam; Seizures; Valproic Acid | 2023 |
[Autosomal dominant mental retardation type 5 caused by
Topics: Child; Codon, Nonsense; Humans; Intellectual Disability; Mutation; ras GTPase-Activating Proteins; R | 2023 |
Antiseizure medications for idiopathic generalized epilepsies: a systematic review and network meta-analysis.
Topics: Anticonvulsants; Child; Epilepsy, Generalized; Ethosuximide; Humans; Levetiracetam; Network Meta-Ana | 2023 |
Management of epilepsy during pregnancy and lactation.
Topics: Breast Feeding; Epilepsy; Female; Humans; Lactation; Pregnancy; Prospective Studies; Seizures; Valpr | 2023 |
Acute symptomatic seizures after stroke: A scoping review on primary prevention, treatment with antiseizure medications and drug discontinuation.
Topics: Anticonvulsants; Humans; Levetiracetam; Primary Prevention; Seizures; Systematic Reviews as Topic; V | 2023 |
Early polytherapy for benzodiazepine-refractory status epilepticus.
Topics: Animals; Anticonvulsants; Benzodiazepines; Drug Administration Schedule; Drug Resistant Epilepsy; Dr | 2019 |
Individual participant data meta-analysis of intervention studies with time-to-event outcomes: A review of the methodology and an applied example.
Topics: Bayes Theorem; Carbamazepine; Data Interpretation, Statistical; Humans; Meta-Analysis as Topic; Prop | 2020 |
A potential cause of adolescent onset Dyke-Davidoff-Masson syndrome: A case report.
Topics: Brain Diseases; Carbamazepine; China; Chronic Disease; Female; Humans; Intellectual Disability; Magn | 2019 |
Dravet syndrome: Treatment options and management of prolonged seizures.
Topics: Anticonvulsants; Diet, Ketogenic; Dioxolanes; Epilepsies, Myoclonic; Humans; Seizures; Valproic Acid | 2019 |
Therapeutic Drug Monitoring of Antiepileptic Drugs in Women with Epilepsy Before, During, and After Pregnancy.
Topics: Anticonvulsants; Drug Monitoring; Epilepsy; Female; Humans; Postpartum Period; Pregnancy; Pregnancy | 2020 |
Antiepileptic drugs as prophylaxis for postcraniotomy seizures.
Topics: Anticonvulsants; Carbamazepine; Craniotomy; Humans; Isoxazoles; Levetiracetam; Phenobarbital; Phenyt | 2020 |
Epilepsy in Angelman syndrome: A scoping review.
Topics: Angelman Syndrome; Anticonvulsants; Child; Child, Preschool; Electroencephalography; Epilepsy; Femal | 2021 |
Ethosuximide, sodium valproate or lamotrigine for absence seizures in children and adolescents.
Topics: Adolescent; Anticonvulsants; Child; Epilepsy, Absence; Ethosuximide; Female; Humans; Lamotrigine; Ma | 2021 |
A systematic review of second line therapies in toxic seizures.
Topics: Anticonvulsants; Female; Humans; Male; Phenytoin; Seizures; Valproic Acid | 2021 |
SNO and EANO practice guideline update: Anticonvulsant prophylaxis in patients with newly diagnosed brain tumors.
Topics: Anticonvulsants; Brain Neoplasms; Humans; Postoperative Period; Seizures; Valproic Acid | 2021 |
Initial Management of Seizure in Adults.
Topics: Adolescent; Adult; Anticonvulsants; Diagnosis, Differential; Electroencephalography; Epilepsy; Ethan | 2021 |
Neuropharmacology of Antiseizure Drugs.
Topics: Anticonvulsants; Epilepsies, Partial; Epilepsy; Epilepsy, Generalized; Humans; Neuropharmacology; Ph | 2021 |
Hematological Consequences of Valproic Acid in Pediatric Patients: A Systematic Review with a Mechanistic Approach.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Female; Hematologic Diseases; Humans; Infant; | 2022 |
Chronic Subdural Hematoma ICU Management.
Topics: Adrenal Cortex Hormones; Craniotomy; Female; Hematoma, Subdural, Chronic; Humans; Intensive Care Uni | 2017 |
Topiramate monotherapy for juvenile myoclonic epilepsy.
Topics: Adolescent; Anticonvulsants; Child; Fructose; Humans; Myoclonic Epilepsy, Juvenile; Randomized Contr | 2017 |
Juvenile myoclonic epilepsy and sleep.
Topics: Adolescent; Adult; Circadian Rhythm; Electroencephalography; Epilepsy, Reflex; Female; Humans; Male; | 2018 |
Antiepileptic drugs as prophylaxis for postcraniotomy seizures.
Topics: Anticonvulsants; Carbamazepine; Craniotomy; Humans; Isoxazoles; Levetiracetam; Phenobarbital; Phenyt | 2018 |
Sodium valproate versus phenytoin monotherapy for epilepsy: an individual participant data review.
Topics: Anticonvulsants; Epilepsies, Partial; Epilepsy, Generalized; Humans; Phenytoin; Randomized Controlle | 2018 |
Valproic Acid and Epilepsy: From Molecular Mechanisms to Clinical Evidences.
Topics: Animals; Anticonvulsants; Brain Injuries, Traumatic; Epilepsy; Histone Deacetylases; Humans; Neurons | 2019 |
Topiramate for juvenile myoclonic epilepsy.
Topics: Adolescent; Anticonvulsants; Child; Humans; Myoclonic Epilepsy, Juvenile; Randomized Controlled Tria | 2019 |
A Practical Guide to Treatment of Childhood Absence Epilepsy.
Topics: Anticonvulsants; Child; Child, Preschool; Drug-Related Side Effects and Adverse Reactions; Electroen | 2019 |
Epilepsy in patients with EAST syndrome caused by mutation in the KCNJ10.
Topics: Anticonvulsants; Brain; Carbamazepine; Cerebellar Ataxia; Child; Child, Preschool; Epilepsy; Female; | 2019 |
Seizure management and prescription patterns of anticonvulsants in Dravet syndrome: A multicenter cohort study from Germany and review of literature.
Topics: Anticonvulsants; Clobazam; Cohort Studies; Drug Prescriptions; Drug Therapy, Combination; Epilepsies | 2019 |
Phenobarbitone versus phenytoin monotherapy for partial onset seizures and generalised onset tonic-clonic seizures.
Topics: Adult; Anticonvulsants; Carbamazepine; Child; Epilepsies, Partial; Epilepsy, Tonic-Clonic; Humans; I | 2013 |
Antiepileptic drugs as prophylaxis for post-craniotomy seizures.
Topics: Anticonvulsants; Carbamazepine; Craniotomy; Humans; Isoxazoles; Phenobarbital; Phenytoin; Randomized | 2013 |
Seizures and intracranial hemorrhage.
Topics: Anticonvulsants; Carbamazepine; Congenital Abnormalities; Eclampsia; Epilepsy; Female; Folic Acid; H | 2013 |
Phenytoin versus valproate monotherapy for partial onset seizures and generalised onset tonic-clonic seizures.
Topics: Anticonvulsants; Epilepsies, Partial; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Humans; Phenyto | 2013 |
Valproic acid-associated low fibrinogen and delayed intracranial hemorrhage: case report and mini literature review.
Topics: Adult; Afibrinogenemia; Anticonvulsants; Cerebral Hemorrhage; Humans; Male; Seizures; Time Factors; | 2013 |
Valproate induced hyperammonemic encephalopathy successfully treated with levocarnitine.
Topics: Adult; Anticonvulsants; Brain Neoplasms; Diagnosis, Differential; Humans; Hyperammonemia; Male; Neur | 2014 |
Analysis of seizure risk factors after allogeneic hematopoietic stem cell transplantation: a 8 case report and literature review.
Topics: Adolescent; Adult; Anticonvulsants; Fatal Outcome; Female; Follow-Up Studies; Hematopoietic Stem Cel | 2013 |
Absence seizures in children.
Topics: Acute Disease; Anticonvulsants; Child; Epilepsy, Absence; Ethosuximide; Evidence-Based Medicine; Hum | 2013 |
Evidence for a potential protective effect of carnitine-pantothenic acid co-treatment on valproic acid-induced hepatotoxicity.
Topics: Animals; Anticonvulsants; Bipolar Disorder; Carnitine; Chemical and Drug Induced Liver Injury; Child | 2014 |
Treating epilepsy in pregnant women.
Topics: Anticonvulsants; Congenital Abnormalities; Epilepsy; Female; Humans; Intellectual Disability; Matern | 2014 |
Pharmacotherapy for tonic-clonic seizures.
Topics: Acetamides; Anticonvulsants; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Fructose; Humans; Lacosa | 2014 |
Antiepileptic drugs as prophylaxis for post-craniotomy seizures.
Topics: Anticonvulsants; Carbamazepine; Craniotomy; Humans; Isoxazoles; Phenobarbital; Phenytoin; Randomized | 2015 |
Antiepileptic drugs in patients with malignant brain tumor: beyond seizures and pharmacokinetics.
Topics: Animals; Anticonvulsants; Brain Neoplasms; Carbamazepine; Humans; Levetiracetam; Piracetam; Seizures | 2016 |
Pharmacologic treatment of status epilepticus.
Topics: Anticonvulsants; Benzodiazepines; Humans; Ketamine; Levetiracetam; Piracetam; Randomized Controlled | 2016 |
Topiramate monotherapy for juvenile myoclonic epilepsy.
Topics: Adolescent; Anticonvulsants; Child; Fructose; Humans; Myoclonic Epilepsy, Juvenile; Randomized Contr | 2015 |
Levocarnitine induced seizures in patients on valproic acid: A negative systematic review.
Topics: Anticonvulsants; Carnitine; Databases, Factual; Humans; Seizures; Valproic Acid | 2016 |
Efficacy and safety of prophylactic levetiracetam in supratentorial brain tumour surgery: a systematic review and meta-analysis.
Topics: Anticonvulsants; Craniotomy; Humans; Levetiracetam; Perioperative Care; Phenytoin; Piracetam; Seizur | 2016 |
Reflex epileptic mechanisms in ictogenesis and therapeutic consequences.
Topics: Epilepsies, Partial; Epilepsy; Epilepsy, Reflex; Humans; Seizures; Valproic Acid | 2016 |
Phenytoin versus valproate monotherapy for partial onset seizures and generalised onset tonic-clonic seizures: an individual participant data review.
Topics: Anticonvulsants; Epilepsies, Partial; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Humans; Phenyto | 2016 |
Antiepileptic dosing for critically ill adult patients receiving renal replacement therapy.
Topics: Acetamides; Acute Kidney Injury; Amines; Anticonvulsants; Carbamates; Critical Illness; Cyclohexanec | 2016 |
[Dynamin-1-related infantile spasms: a case report and review of literature].
Topics: Child; Child, Preschool; Developmental Disabilities; Dynamin I; Electroencephalography; Epilepsy; Fe | 2016 |
Valproic acid-induced hyperammonemic encephalopathy in a full-term neonate: a brief review and case report.
Topics: Anticonvulsants; Brain Diseases; Humans; Hyperammonemia; Infant, Newborn; Seizures; Valproic Acid | 2017 |
Guidelines for seizure management in palliative care: Proposal for an updated clinical practice model based on a systematic literature review.
Topics: Anticonvulsants; Carbamazepine; Guidelines as Topic; Humans; Levetiracetam; Palliative Care; Seizure | 2019 |
Epileptic disorders in pregnancy: an overview.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Carbamazepine; Epilepsy; Female; Folic Acid; Hemorrhag | 2008 |
[Endocrine effects of antiepileptic drugs].
Topics: Anticonvulsants; Carbamazepine; Endocrine System Diseases; Estradiol; Female; Hormones; Humans; Leve | 2008 |
[Do results of the recent clinical trials change the place of valproate in treatment of epilepsy?].
Topics: Anticonvulsants; Clinical Trials as Topic; Epilepsy; Humans; Seizures; Valproic Acid | 2008 |
New antiepileptic drugs: molecular targets.
Topics: Action Potentials; Animals; Anticonvulsants; Barbiturates; Carbamazepine; Clinical Trials as Topic; | 2009 |
Valproic acid-carbapenem interaction: report of six cases and a review of the literature.
Topics: Adult; Aged; Anticonvulsants; Antimanic Agents; Carbapenems; Drug Interactions; Female; Humans; Male | 2009 |
Tolerance to the prophylactic effects of carbamazepine and related mood stabilizers in the treatment of bipolar disorders.
Topics: Amygdala; Animals; Anticonvulsants; Bipolar Disorder; Carbamazepine; Drug Resistance; Drug Tolerance | 2011 |
Management of acute seizure and status epilepticus in pediatric emergency.
Topics: Anesthesia, Intravenous; Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Combined Modalit | 2012 |
Valproic acid-induced eosinophilic pleural effusion: a case report and review of the literature.
Topics: Adult; Eosinophilia; Exudates and Transudates; Humans; Male; Pleural Effusion; Seizures; Valproic Ac | 2012 |
Antiepileptic drug-induced pharmacodynamic aggravation of seizures: does valproate have a lower potential?
Topics: Anticonvulsants; Drug Interactions; Female; Humans; Male; Risk Factors; Seizures; Valproic Acid | 2003 |
Seizure prophylaxis in patients with brain tumors: a meta-analysis.
Topics: Anticonvulsants; Brain Neoplasms; Comorbidity; Confidence Intervals; Dose-Response Relationship, Dru | 2004 |
Myelodysplastic syndrome associated with chronic valproic acid therapy: a case report and review of the literature.
Topics: Cytogenetic Analysis; Female; Histone Deacetylase Inhibitors; Humans; Middle Aged; Myelodysplastic S | 2007 |
[Caffeine and antiepileptic drugs: experimental and clinical data].
Topics: Animals; Anticonvulsants; Caffeine; Carbamazepine; Dose-Response Relationship, Drug; Drug Interactio | 2007 |
Cellular compartments of GABA in brain and their relationship to anticonvulsant activity.
Topics: 4-Aminobutyrate Transaminase; Aminocaproates; Aminooxyacetic Acid; Animals; Anticonvulsants; Brain; | 1981 |
Central actions of valproic acid in man and in experimental models of epilepsy.
Topics: 4-Aminobutyrate Transaminase; Action Potentials; Alcohol Oxidoreductases; Aldehyde Oxidoreductases; | 1981 |
Advances in pediatric pharmacology and toxicology.
Topics: Animals; Anti-Bacterial Agents; Aspirin; Attention Deficit Disorder with Hyperactivity; Biological A | 1983 |
Drug therapy: Valproic acid.
Topics: Adult; Alopecia; Behavior; Blood Coagulation Disorders; Chemical and Drug Induced Liver Injury; Chil | 1980 |
Sodium valproate.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Humans; Kinetics; Phenobarbital; Seizures; Structu | 1980 |
Valproic acid: interactions with phenytoin and phenobarbital.
Topics: Binding, Competitive; Drug Interactions; Half-Life; Humans; Kinetics; Phenobarbital; Phenytoin; Prot | 1982 |
Fatal acute pancreatitis caused by valproic acid.
Topics: Acute Disease; Adult; Cerebral Palsy; Fatal Outcome; Female; Humans; Pancreatitis; Seizures; Valproi | 1995 |
Criteria for use of valproate in adult psychiatric inpatients and outpatients.
Topics: Adult; Anticonvulsants; Antimanic Agents; Bipolar Disorder; Female; Humans; Male; Practice Guideline | 1996 |
Clinical use of drugs useful in the treatment of atonic seizures.
Topics: Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Clobazam; Epilepsy, Genera | 1995 |
A speculative model of affective illness cyclicity based on patterns of drug tolerance observed in amygdala-kindled seizures.
Topics: Affect; Amygdala; Animals; Anticonvulsants; Bipolar Disorder; Carbamazepine; Disease Progression; Dr | 1996 |
New drug therapy for acute seizure management.
Topics: Acute Disease; Anticonvulsants; Child; Diazepam; Epilepsy; Humans; Phenytoin; Prodrugs; Seizures; Va | 1997 |
Anticonvulsant therapy in small animals.
Topics: Acetates; Amines; Animals; Anticonvulsants; Bromides; Clonazepam; Clorazepate Dipotassium; Cyclohexa | 1998 |
The use of valproic acid in HIV-positive patients.
Topics: Anticonvulsants; HIV Infections; Humans; Seizures; Valproic Acid | 1999 |
Epilepsy therapy: issues for women and men.
Topics: Anticonvulsants; Congenital Abnormalities; Epilepsy; Epilepsy, Temporal Lobe; Female; Humans; Infert | 2001 |
Antiepileptogenesis and seizure prevention trials with antiepileptic drugs: meta-analysis of controlled trials.
Topics: Anticonvulsants; Brain Diseases; Brain Injuries; Carbamazepine; Controlled Clinical Trials as Topic; | 2001 |
Prevention and management of febrile seizures.
Topics: Anticonvulsants; Child, Preschool; Humans; Incidence; Infant; Phenobarbital; Randomized Controlled T | 2001 |
Phenytoin versus valproate monotherapy for partial onset seizures and generalized onset tonic-clonic seizures.
Topics: Anticonvulsants; Epilepsies, Partial; Epilepsy, Generalized; Humans; Phenytoin; Randomized Controlle | 2001 |
Valproic acid. Review of a new antiepileptic drug.
Topics: Adolescent; Adult; Animals; Brain Chemistry; Drug Interactions; Electric Stimulation; Electroencepha | 1979 |
Pharmacological and biochemical studies in epileptic fowl.
Topics: Animals; Anticonvulsants; Benzodiazepinones; Brain; Chickens; Disease Models, Animal; Ethosuximide; | 1979 |
Pharmacological prophylaxis in the kindling model of epilepsy.
Topics: Amygdala; Anesthetics, Local; Animals; Antidepressive Agents, Tricyclic; Atropine; Aziridines; Carba | 1977 |
Sodium di-N-propylacetate (DPA) in the treatment of epilepsy. A review.
Topics: Adolescent; Adult; Age Factors; Animals; Cerebral Cortex; Child; Child, Preschool; Drug Evaluation; | 1975 |
Rational use of antiepileptic drug levels.
Topics: Carbamazepine; Half-Life; Humans; Phenobarbital; Phenytoin; Seizures; Valproic Acid | 1992 |
Valproic acid.
Topics: Dosage Forms; Drug Administration Schedule; Drug Interactions; Female; Humans; Infant, Newborn; Milk | 1991 |
Intraoperative defect in haemostasis in a child receiving valproic acid.
Topics: Child; Hemostasis, Surgical; Humans; Intraoperative Period; Male; Seizures; Valproic Acid | 1991 |
[Reye's syndrome in children (review of the literature)].
Topics: Acute Disease; Child; Child, Preschool; Humans; Infant; Infant, Newborn; Respiratory Tract Infection | 1990 |
Drugs acting on amino acid neurotransmitters.
Topics: Acoustic Stimulation; Amino Acids; Animals; Chemical Phenomena; Chemistry; Diazepam; Electrophysiolo | 1986 |
Epilepsy and the blood-brain barrier.
Topics: Animals; Animals, Newborn; Anticonvulsants; Biological Transport; Biomechanical Phenomena; Blood Pro | 1986 |
[Therapy of brain-related minor seizures].
Topics: Anticonvulsants; Carbamazepine; Electroencephalography; Epilepsies, Myoclonic; Epilepsies, Partial; | 1988 |
50 trials available for valproic acid and Seizures
| Article | Year |
|---|---|
Effects of in utero exposure to valproate or levetiracetam on the seizures and newborn histopathology of genetic absence epilepsy rats.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Electroencephalography; Epilepsy, Absence; Female; | 2022 |
Seizure prophylaxis following aneurysmal subarachnoid haemorrhage (SPSAH): study protocol for a multicentre randomised placebo-controlled trial of short-term sodium valproate prophylaxis in patients with acute subarachnoid haemorrhage.
Topics: Aneurysm, Ruptured; Humans; Multicenter Studies as Topic; Randomized Controlled Trials as Topic; Sei | 2022 |
Treatment of Toxin-Related Status Epilepticus With Levetiracetam, Fosphenytoin, or Valproate in Patients Enrolled in the Established Status Epilepticus Treatment Trial.
Topics: Adult; Alcoholism; Analgesics, Opioid; Anticonvulsants; Benzodiazepines; Child; Cocaine; Female; Hum | 2022 |
Model-Informed Precision Dosing Guidance of Ethosuximide Developed from a Randomized Controlled Clinical Trial of Childhood Absence Epilepsy.
Topics: Anticonvulsants; Epilepsy, Absence; Ethosuximide; Humans; Seizures; Valproic Acid | 2023 |
Comparison of lacosamide versus sodium valproate in status epilepticus: A pilot study.
Topics: Acetamides; Administration, Intravenous; Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants | 2017 |
Downregulation of microRNA‑155 by preoperative administration of valproic acid prevents postoperative seizures by upregulating SCN1A.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Base Sequence; Binding Sites; Cell Line; Down-Regulation; | 2018 |
Long-term cannabidiol treatment in patients with Dravet syndrome: An open-label extension trial.
Topics: Adolescent; Adult; Anticonvulsants; Cannabidiol; Child; Child, Preschool; Double-Blind Method; Drug | 2019 |
Protocol for seizure prophylaxis following intracerebral hemorrhage study (SPICH): a randomized, double-blind, placebo-controlled trial of short-term sodium valproate prophylaxis in patients with acute spontaneous supratentorial intracerebral hemorrhage.
Topics: Acute Disease; Anticonvulsants; Cerebral Hemorrhage; China; Clinical Protocols; Double-Blind Method; | 2014 |
Time to 12-month remission and treatment failure for generalised and unclassified epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Child; Electroencephalography; Epilepsy, Generalized; Female; Fr | 2014 |
Efficacy and safety of ezogabine/retigabine as adjunctive therapy to specified single antiepileptic medications in an open-label study of adults with partial-onset seizures.
Topics: Aged; Anticonvulsants; Carbamates; Carbamazepine; Dose-Response Relationship, Drug; Drug Therapy, Co | 2015 |
Comparative effectiveness of levetiracetam, valproate and carbamazepine among elderly patients with newly diagnosed epilepsy: subgroup analysis of the randomized, unblinded KOMET study.
Topics: Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Levetiracetam; Ma | 2016 |
Comparison of add-on valproate and primidone in carbamazepine-unresponsive patients with partial epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Drug Therapy, Combination; Epilepsies, Par | 2009 |
Seizure control and side-effect profile after switching adult epileptic patients from standard to extended-release divalproex sodium.
Topics: Activities of Daily Living; Adult; Anticonvulsants; Body Weight; Cohort Studies; Data Interpretation | 2009 |
Divalproex sodium in children with partial seizures: 12-month safety study.
Topics: Anticonvulsants; Child; Child, Preschool; Epilepsies, Partial; Female; Humans; Male; Neuropsychologi | 2009 |
Overnight versus progressive conversion of multiple daily-dose divalproex to once-daily divalproex extended release: which strategy is better tolerated by adults with intellectual disabilities?
Topics: Adult; Delayed-Action Preparations; Drug Administration Schedule; Female; Humans; Intellectual Disab | 2009 |
Experience in the use of the anticonvulsant pregabalin as an add-on therapy in patients with partial epilepsy with polymorphic seizures.
Topics: Adolescent; Adult; Age of Onset; Anticonvulsants; Carbamazepine; Databases as Topic; Drug Therapy, C | 2010 |
Ethosuximide, valproic acid, and lamotrigine in childhood absence epilepsy.
Topics: Adolescent; Analysis of Variance; Anticonvulsants; Attention Deficit and Disruptive Behavior Disorde | 2010 |
[Comparative efficacy of carbamazepine, valproic acid and topiramate in symptomatic and cryptogenic occipital lobe epilepsy in children].
Topics: Adolescent; Anticonvulsants; Benzodiazepines; Brain Injuries; Carbamazepine; Child; Epilepsies, Part | 2010 |
Are post intracerebral hemorrhage seizures prevented by anti-epileptic treatment?
Topics: Aged; Aged, 80 and over; Anticonvulsants; Cerebral Hemorrhage; Female; Follow-Up Studies; Humans; Ma | 2011 |
[Observation on therapeutic effect of acupoint catgut-embedding combined western medicine for epilepsy of generalized seizures type].
Topics: Acupuncture Points; Acupuncture Therapy; Adolescent; Adult; Anticonvulsants; Catgut; Child; Child, P | 2011 |
Comparative efficacy and safety of intravenous valproate and phenytoin in children.
Topics: Child; Child, Preschool; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Infusions, In | 2011 |
Efficacy and safety of intravenous sodium valproate versus phenobarbital in controlling convulsive status epilepticus and acute prolonged convulsive seizures in children: a randomised trial.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Female; Humans; Infusions, Intravenous; Male; | 2012 |
[Efficacy and safety of the combined therapy of valproic acid and lamotrigine for epileptics].
Topics: Child; Child, Preschool; Drug Therapy, Combination; Epilepsies, Partial; Epilepsy; Epilepsy, Absence | 2012 |
Effects of fluoxetine on the anticonvulsant action of valproate and ethosuximide in mouse model of myoclonic convulsions.
Topics: Animals; Anticonvulsants; Antidepressive Agents, Second-Generation; Avoidance Learning; Convulsants; | 2012 |
Assessment of cognitive impairments and seizure characteristics in electroconvulsive therapy with and without sodium valproate in manic patients.
Topics: Adult; Anticonvulsants; Bipolar Disorder; Cognition Disorders; Combined Modality Therapy; Double-Bli | 2013 |
Divalproex extended-release versus the original divalproex tablet: results of a randomized, crossover study of well-controlled epileptic patients with primary generalized seizures.
Topics: Adolescent; Adult; Analysis of Variance; Asthenia; Child; Cross-Over Studies; Delayed-Action Prepara | 2002 |
Long-term neuropsychological follow-up and nosological considerations in five patients with continuous spikes and waves during slow sleep.
Topics: Adrenocorticotropic Hormone; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Child; Child, Pr | 2002 |
Topiramate, carbamazepine and valproate monotherapy: double-blind comparison in newly diagnosed epilepsy.
Topics: Administration, Oral; Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Child; Double-Blind M | 2003 |
Lamotrigine monotherapy compared with carbamazepine, phenytoin, or valproate monotherapy in patients with epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Evaluation | 2003 |
Tiagabine as add-on therapy may be more effective with valproic acid--open label, multicentre study of patients with focal epilepsy.
Topics: Adolescent; Adult; Age Factors; Aged; Anticonvulsants; Carbamazepine; Child; Data Interpretation, St | 2005 |
Intravenous valproate as an innovative therapy in seizure emergency situations including status epilepticus--experience in 102 adult patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Benzodiazepines; Female; Humans; Inject | 2005 |
[Evaluation of therapeutic project on acute tetramethylene disulphotetramine poisoning and effect on intelligence in children].
Topics: Acute Disease; Adolescent; Adult; Anticonvulsants; Antidotes; Bridged-Ring Compounds; Child; Female; | 2005 |
Valproic acid monotherapy induces DNA oxidative damage.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Anticonvulsants; Antioxidants; Biomarkers; Child; Child, Preschool; Deo | 2006 |
Effect of time, injury, age and ethanol on interpatient variability in valproic acid pharmacokinetics after traumatic brain injury.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Brain Injuries; Craniotomy; Cytokines; | 2007 |
Topiramate or valproate in patients with juvenile myoclonic epilepsy: a randomized open-label comparison.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; Double-Blind Method; Female; Fructose; Humans; Magn | 2007 |
[DPA and clonazepam activity in febrile convulsions: preliminary results].
Topics: Benzodiazepinones; Child, Preschool; Clinical Trials as Topic; Clonazepam; Humans; Infant; Receptors | 1980 |
Drug therapy: Valproic acid.
Topics: Adult; Alopecia; Behavior; Blood Coagulation Disorders; Chemical and Drug Induced Liver Injury; Chil | 1980 |
Continuous sodium valproate or phenobarbitone in the prevention of 'simple' febrile convulsions. Comparison by a double-blind trial.
Topics: Clinical Trials as Topic; Double-Blind Method; Female; Humans; Infant; Male; Phenobarbital; Random A | 1980 |
Sodium valproate in the treatment of the alcohol withdrawal syndrome.
Topics: Adult; Alcoholism; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Seizures; Substance | 1980 |
[Gamma-vinyl-GABA: first experiences in Italy. II].
Topics: Adolescent; Adult; Aminocaproates; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; | 1994 |
A randomized, blinded, placebo-controlled trial of divalproex sodium prophylaxis in adults with newly diagnosed brain tumors.
Topics: Anticonvulsants; Brain Neoplasms; Data Collection; Double-Blind Method; Female; Humans; Incidence; M | 1996 |
Effects of switching from Depakene to generic valproic acid on individuals with mental retardation.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Cross-Over Studies; Drugs, Generic; Humans; Intellectual D | 1997 |
Increases in metabolism of valproate and excretion of 6beta-hydroxycortisol in patients with traumatic brain injury.
Topics: Adult; Aged; Anticonvulsants; Brain Damage, Chronic; Brain Injuries; Female; Humans; Hydrocortisone; | 1998 |
Valproate as monotherapy for juvenile myoclonic epilepsy: dose-effect study.
Topics: Adolescent; Adult; Anticonvulsants; Area Under Curve; Disease-Free Survival; Dose-Response Relations | 1998 |
Benign myoclonic epilepsy in infants: video-EEG features and long-term follow-up.
Topics: Adolescent; Adult; Child; Child, Preschool; Electroencephalography; Epilepsies, Myoclonic; Female; F | 1998 |
Does withdrawal of different antiepileptic drugs have different effects on seizure recurrence? Further results from the MRC Antiepileptic Drug Withdrawal Study.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Drug Combinations; Epilepsy; Female; Human | 1999 |
Lack of a clinically significant pharmacokinetic drug interaction between tiagabine and valproate.
Topics: Adolescent; Adult; Anticonvulsants; Dizziness; Drug Interactions; Drug Monitoring; Drug Therapy, Com | 1998 |
Valproate therapy for prevention of posttraumatic seizures: a randomized trial.
Topics: Adult; Anticonvulsants; Blood Coagulation Disorders; Brain Injuries; Chemical and Drug Induced Liver | 1999 |
The safety of rapid valproic acid infusion.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Blood Pressure; Female; Heart Rate; Humans; Hypotension; I | 2000 |
First seizure in adults: to treat or not to treat.
Topics: Adolescent; Adult; Aged; Double-Blind Method; Drug Administration Schedule; Electroencephalography; | 1992 |
903 other studies available for valproic acid and Seizures
| Article | Year |
|---|---|
Synthesis and anticonvulsant activity of enaminones.
Topics: Amines; Animals; Anticonvulsants; Drug Evaluation, Preclinical; Electric Stimulation; Kindling, Neur | 1992 |
2-Phenyl-3H-imidazo[4,5-b]pyridine-3-acetamides as non-benzodiazepine anticonvulsants and anxiolytics.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Anxiety; Benzodiazepines; Binding, Competitive; Cereb | 1991 |
Synthesis and anticonvulsant activity of 1-acyl-2-pyrrolidinone derivatives.
Topics: Animals; Anticonvulsants; Chemical Phenomena; Chemistry; gamma-Aminobutyric Acid; Male; Mice; Pyrrol | 1991 |
Preparation and anticonvulsant activity of a series of functionalized alpha-heteroatom-substituted amino acids.
Topics: Acetamides; Amino Acids; Animals; Anticonvulsants; Chemical Phenomena; Chemistry; Electroshock; Male | 1991 |
Metabolism of 3-(p-chlorophenyl)pyrrolidine. Structural effects in conversion of a prototype gamma-aminobutyric acid prodrug to lactam and gamma-aminobutyric acid type metabolites.
Topics: Amino Acids; Animals; Baclofen; Brain; Chemical Phenomena; Chemistry; Chromatography, High Pressure | 1989 |
Synthesis and anticonvulsant properties of 2,3,3a,4-tetrahydro-1H-pyrrolo[1,2-a]benzimidazol-1-ones.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Benzimidazoles; Chemical Phenomena; Chemistry; Drug | 1989 |
Triazolines. 14. 1,2,3-Triazolines and triazoles, a new class of anticonvulsants. Drug design and structure-activity relationships.
Topics: Animals; Anticonvulsants; Electroshock; Mice; Seizures; Structure-Activity Relationship; Triazoles | 1988 |
Anticonvulsant activity of 2- and 3-aminobenzanilides.
Topics: Anilides; Aniline Compounds; Animals; Anticonvulsants; Electroshock; Male; Mice; Pentylenetetrazole; | 1986 |
Functionalized DL-amino acid derivatives. Potent new agents for the treatment of epilepsy.
Topics: Amino Acids; Animals; Anticonvulsants; Epilepsy; Magnetic Resonance Spectroscopy; Male; Mice; Seizur | 1987 |
Anticonvulsant activity of some 4-aminobenzanilides.
Topics: Anilides; Animals; Chemical Phenomena; Chemistry; Drug Evaluation, Preclinical; Electroshock; Male; | 1985 |
Synthesis and anticonvulsant activity of some substituted lactams and amides.
Topics: Amides; Animals; Anticonvulsants; Chemical Phenomena; Chemistry; Lactams; Mice; Piperidines; Seizure | 1984 |
Potential anticonvulsants. 1. 5-Benzylhydantoins.
Topics: Animals; Anticonvulsants; Drug Evaluation, Preclinical; Hydantoins; Male; Mice; Rats; Seizures; Stru | 1981 |
Structure-activity relationships of unsaturated analogues of valproic acid.
Topics: Animals; Gas Chromatography-Mass Spectrometry; Magnetic Resonance Spectroscopy; Mice; Seizures; Stru | 1995 |
Synthesis and anticonvulsant activities of alpha-heterocyclic alpha-acetamido-N-benzylacetamide derivatives.
Topics: Acetamides; Animals; Anticonvulsants; Benzeneacetamides; Benzyl Compounds; Furans; Heterocyclic Comp | 1993 |
Synthesis and CLOGP correlation of imidooxy anticonvulsants.
Topics: Animals; Anticonvulsants; Chemical Phenomena; Chemistry, Physical; Crystallography, X-Ray; Electrosh | 1993 |
5-Aryl-3-(alkylthio)-4H-1,2,4-triazoles as selective antagonists of strychnine-induced convulsions and potential antispastic agents.
Topics: Animals; Anticonvulsants; Cerebellum; Cerebral Cortex; Chlorides; Electroshock; Flumazenil; Male; Mi | 1994 |
(Aryloxy)aryl semicarbazones and related compounds: a novel class of anticonvulsant agents possessing high activity in the maximal electroshock screen.
Topics: Animals; Anticonvulsants; Binding Sites; Crystallography, X-Ray; Dose-Response Relationship, Drug; D | 1996 |
Aroyl(aminoacyl)pyrroles, a new class of anticonvulsant agents.
Topics: Anesthesia; Animals; Anticonvulsants; Bicuculline; Calcium; Cerebellum; Electroshock; Mice; Models, | 1997 |
N-(benzyloxycarbonyl)glycine esters and amides as new anticonvulsants.
Topics: 3-Mercaptopropionic Acid; Amides; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electr | 1998 |
Synthesis and anticonvulsant activity of a new class of 2-[(arylalky)amino]alkanamide derivatives.
Topics: Alanine; Animals; Anticonvulsants; Benzylamines; Bicuculline; Drug Design; Electroshock; Indicators | 1998 |
Synthesis and anticonvulsant activity of 2(3H)-benzoxazolone and 2(3H)-benzothiazolone derivatives.
Topics: Animals; Anticonvulsants; Electric Stimulation; Injections, Intraperitoneal; Male; Mice; Oxazoles; R | 1998 |
Synthesis and structural studies of aza analogues of functionalized amino acids: new anticonvulsant agents.
Topics: Animals; Anticonvulsants; Aza Compounds; Crystallography, X-Ray; Electroshock; Magnetic Resonance Sp | 2001 |
Design and evaluation of affinity labels of functionalized amino acid anticonvulsants.
Topics: Affinity Labels; Amino Acids; Animals; Anticonvulsants; Electroshock; Isothiocyanates; Mice; Radioli | 2002 |
Tetramethylcyclopropyl analogue of a leading antiepileptic drug, valproic acid. Synthesis and evaluation of anticonvulsant activity of its amide derivatives.
Topics: Animals; Anticonvulsants; Convulsants; Cyclopropanes; Electroshock; Mice; Pentylenetetrazole; Polyun | 2004 |
Synthesis and anticonvulsant activity of 7-alkoxyl-4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolines.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Mice; Neurotoxicity Syndromes; Quinolines; Seizure | 2005 |
Discovery of N-(2,6-dimethylphenyl)-substituted semicarbazones as anticonvulsants: hybrid pharmacophore-based design.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Benzamides; Chemical and Drug Induced Liver | 2005 |
Synthesis of some novel N4-(naphtha[1,2-d]thiazol-2-yl)semicarbazides as potential anticonvulsants.
Topics: Animals; Anticonvulsants; Brain Chemistry; Glutathione Peroxidase; Malondialdehyde; Mice; Motor Acti | 2009 |
Solution-phase parallel synthesis and evaluation of anticonvulsant activity of N-substituted-3,4-dihydroisoquinoline-2(1H)-carboxamides.
Topics: Animals; Anticonvulsants; Isoquinolines; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred DBA; Se | 2009 |
Synthesis and anticonvulsant activity of aromatic tetramethylcyclopropanecarboxamide derivatives.
Topics: Administration, Oral; Amides; Animals; Anticonvulsants; Cyclopropanes; Electroshock; Isoxazoles; Mic | 2008 |
Design and synthesis of 6-amino-1,4-oxazepane-3,5-dione derivatives as novel broad spectrum anticonvulsants.
Topics: Animals; Anticonvulsants; Combinatorial Chemistry Techniques; Drug Design; Electroshock; Male; Mice; | 2008 |
Synthesis and evaluation of antiallodynic and anticonvulsant activity of novel amide and urea derivatives of valproic acid analogues.
Topics: Amides; Animals; Anticonvulsants; Electroshock; Isomerism; Male; Mice; Pain; Pentylenetetrazole; Rat | 2009 |
Synthesis, anticonvulsant and antimicrobial activities of some new 2-acetylnaphthalene derivatives.
Topics: Animals; Anti-Infective Agents; Anticonvulsants; Crystallography, X-Ray; Imidazoles; Molecular Confo | 2010 |
Syntheses and evaluation of anticonvulsant profile and teratogenicity of novel amide derivatives of branched aliphatic carboxylic acids with 4-aminobenzensulfonamide.
Topics: Anilides; Animals; Anticonvulsants; Convulsants; Electroshock; Mice; Neural Tube Defects; Pentylenet | 2010 |
The structure-activity relationship of the 3-oxy site in the anticonvulsant (R)-N-benzyl 2-acetamido-3-methoxypropionamide.
Topics: Acetamides; Animals; Anticonvulsants; Electroshock; Hydrophobic and Hydrophilic Interactions; Lacosa | 2010 |
Primary amino acid derivatives: compounds with anticonvulsant and neuropathic pain protection activities.
Topics: Amino Acids; Analgesics; Animals; Anticonvulsants; Convulsants; Electroshock; Formaldehyde; Male; Mi | 2011 |
Synthesis and anticonvulsant activity of trans- and cis-2-(2,6-dimethylphenoxy)-N-(2- or 4-hydroxycyclohexyl)acetamides and their amine analogs.
Topics: Acetamides; Amines; Animals; Anticonvulsants; Mice; Rats; Seizures | 2011 |
Syntheses and evaluation of anticonvulsant activity of novel branched alkyl carbamates.
Topics: Animals; Anticonvulsants; Carbamates; Male; Mice; Neurotoxicity Syndromes; Rats; Rats, Sprague-Dawle | 2012 |
Synthesis and anticonvulsant activity of ethyl 1-(2-arylhydrazinecarboxamido)-2,2-dimethylcyclopropanecarboxylate derivatives.
Topics: Animals; Anticonvulsants; Chemistry Techniques, Synthetic; Hydrazines; Male; Mice; Motor Activity; R | 2012 |
Design, synthesis and anticonvulsant properties of new N-Mannich bases derived from 3-phenylpyrrolidine-2,5-diones.
Topics: Administration, Oral; Animals; Anticonvulsants; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhib | 2013 |
Seizure prevention by the naturally occurring phenols, carvacrol and thymol in a partial seizure-psychomotor model.
Topics: Animals; Anticonvulsants; Cymenes; Disease Models, Animal; Monoterpenes; Phenols; Psychomotor Perfor | 2014 |
Design, synthesis and pharmacological evaluation of N-[4-(4-(alkyl/aryl/heteroaryl)-piperazin-1-yl)-phenyl]-carbamic acid ethyl ester derivatives as novel anticonvulsant agents.
Topics: Animals; Anticonvulsants; Carbamates; Drug Design; Electroshock; Epilepsy; Mice; Pentylenetetrazole; | 2015 |
Design, synthesis and biological evaluation of new hybrid anticonvulsants derived from N-benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide and 2-(2,5-dioxopyrrolidin-1-yl)butanamide derivatives.
Topics: Amides; Animals; Anticonvulsants; Benzylamines; Convulsants; Disease Models, Animal; Dose-Response R | 2015 |
Chimeric derivatives of functionalized amino acids and α-aminoamides: compounds with anticonvulsant activity in seizure models and inhibitory actions on central, peripheral, and cardiac isoforms of voltage-gated sodium channels.
Topics: Acetamides; Administration, Oral; Amides; Amino Acids; Animals; Anticonvulsants; Cerebral Cortex; El | 2015 |
Design, synthesis, and anticonvulsant activity of new hybrid compounds derived from 2-(2,5-dioxopyrrolidin-1-yl)propanamides and 2-(2,5-dioxopyrrolidin-1-yl)butanamides.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Design; Ele | 2015 |
Design, synthesis and biological activity of new amides derived from 3-methyl-3-phenyl-2,5-dioxo-pyrrolidin-1-yl-acetic acid.
Topics: Acetates; Amides; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug | 2015 |
Synthesis of 2,6-dicarbethoxy-3,5-diaryltetrahydro-1,4-thiazine-1,1-dioxide derivatives as potent anticonvulsant agents.
Topics: Animals; Anticonvulsants; Crystallography, X-Ray; Cyclic S-Oxides; Disease Models, Animal; Dose-Resp | 2015 |
Anticonvulsant activity, crystal structures, and preliminary safety evaluation of N-trans-cinnamoyl derivatives of selected (un)modified aminoalkanols.
Topics: Amino Alcohols; Animals; Anticonvulsants; Crystallography, X-Ray; Disease Models, Animal; Drug Evalu | 2016 |
Chlorophenoxy aminoalkyl derivatives as histamine H(3)R ligands and antiseizure agents.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroshock; Humans; Ligands; Male; Mic | 2016 |
New hybrid molecules with anticonvulsant and antinociceptive activity derived from 3-methyl- or 3,3-dimethyl-1-[1-oxo-1-(4-phenylpiperazin-1-yl)propan-2-yl]pyrrolidine-2,5-diones.
Topics: Analgesics; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Elec | 2016 |
Synthesis, and anticonvulsant activity of new amides derived from 3-methyl- or 3-ethyl-3-methyl-2,5-dioxo-pyrrolidin-1-yl-acetic acids.
Topics: Amides; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Electros | 2016 |
Design, synthesis and anticonvulsant activity of new hybrid compounds derived from N-phenyl-2-(2,5-dioxopyrrolidin-1-yl)-propanamides and -butanamides.
Topics: Amides; Animals; Anticonvulsants; Calcium Channels; Drug Design; Humans; Injections, Intraperitoneal | 2016 |
Design and comparative anticonvulsant activity assessment of CNS-active alkyl-carbamoyl imidazole derivatives.
Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Carbamates; Electroshock; Imidazoles; Male; Mice; Rat | 2016 |
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH
Topics: Amino Alcohols; Animals; Anticonvulsants; Crystallography, X-Ray; Disease Models, Animal; Dose-Respo | 2017 |
Synthesis and evaluation of anticonvulsant properties of new N-Mannich bases derived from pyrrolidine-2,5-dione and its 3-methyl-, 3-isopropyl, and 3-benzhydryl analogs.
Topics: Animals; Anticonvulsants; Mannich Bases; Mice; Pyrrolidines; Seizures | 2017 |
Selective Blockade of Neuronal BK (α + β4) Channels Preventing Epileptic Seizure.
Topics: Animals; Anticonvulsants; GABA-A Receptor Antagonists; Humans; Large-Conductance Calcium-Activated P | 2020 |
Design, synthesis, molecular docking and pharmacological evaluation of novel triazine-based triazole derivatives as potential anticonvulsant agents.
Topics: Anticonvulsants; Electroshock; Humans; Molecular Docking Simulation; Molecular Structure; Pentylenet | 2022 |
Response to sertraline and antiepileptic drugs in pentylenetetrazole kindling in rats.
Topics: Animals; Anticonvulsants; Avoidance Learning; Cognition Disorders; Convulsants; Glutathione; Kindlin | 2021 |
[Women with epilepsy before and during pregnancy: a case series of outpatient counseling in a tertiary epilepsy center].
Topics: Anticonvulsants; Counseling; Epilepsy; Female; Folic Acid; Humans; Lamotrigine; Levetiracetam; Outpa | 2022 |
Valproic acid for children below 2 years of age with epilepsy.
Topics: Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Male; Retrospective Stud | 2021 |
Seizure outcome trajectories in a well-defined cohort of newly diagnosed juvenile myoclonic epilepsy patients.
Topics: Anticonvulsants; Female; Humans; Myoclonic Epilepsy, Juvenile; Retrospective Studies; Seizures; Valp | 2022 |
Anticonvulsive Effects of Chondroitin Sulfate on Pilocarpine and Pentylenetetrazole Induced Epileptogenesis in Mice.
Topics: Animals; Anticonvulsants; Chondroitin Sulfates; Male; Mice; Molecular Docking Simulation; Neuroprote | 2021 |
Maternal Duplication 15q11-13 Syndrome with Autism Spectrum Disorder: Mood Stabilization by Carbamazepine.
Topics: Anticonvulsants; Antimanic Agents; Autism Spectrum Disorder; Benzodiazepines; Carbamazepine; Humans; | 2022 |
Valproate Induced Acute Pancreatitis - A Unique Case Report.
Topics: Acute Disease; Adolescent; Child; Humans; Pancreatitis; Seizures; Valproic Acid | 2022 |
Transcranial photobiomodulation add-on therapy to valproic acid for pentylenetetrazole-induced seizures in peripubertal rats.
Topics: Animals; Anticonvulsants; Humans; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Seizures; Valproic | 2022 |
Antiseizure Medications Withdrawal Seizures in Patients with Juvenile Myoclonic Epilepsy.
Topics: Anticonvulsants; Female; Humans; Myoclonic Epilepsy, Juvenile; Seizures; Substance Withdrawal Syndro | 2022 |
Trends in the choice of antiseizure medications in juvenile myoclonic epilepsy: A retrospective multi-center study from Turkey between 2010 and 2020.
Topics: Adolescent; Anticonvulsants; Child; Female; Humans; Lamotrigine; Levetiracetam; Male; Myoclonic Epil | 2022 |
Digoxin at sub-cardiotonic dose modulates the anticonvulsive potential of valproate, levetiracetam and topiramate in experimental primary generalized seizures.
Topics: Animals; Anticonvulsants; Camphor; Cardiotonic Agents; Digoxin; Levetiracetam; Male; Mice; Picrotoxi | 2022 |
4-Phenylbutyric Acid Plus Valproic Acid Exhibits the Therapeutic and Neuroprotective Effects in Acute Seizures Induced by Pentylenetetrazole.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Male; Neuroprotective Agents; Pentylenet | 2022 |
Risk factors of elevated blood ammonia level in epilepsy patients treated with lamotrigine.
Topics: Ammonia; Anticonvulsants; Epilepsy; Humans; Hyperammonemia; Lamotrigine; Risk Factors; Seizures; Tri | 2022 |
Efficacy and safety of antiseizure medication in post-stroke epilepsy.
Topics: Anticonvulsants; Epilepsies, Partial; Epilepsy; Humans; Lacosamide; Lamotrigine; Levetiracetam; Seiz | 2022 |
Seizure control in mono- and combination therapy in a cohort of patients with Idiopathic Generalized Epilepsy.
Topics: Adolescent; Anticonvulsants; Drug Therapy, Combination; Epilepsy, Generalized; Female; Humans; Immun | 2022 |
Pharmacotherapeutic management of seizures in patients with Angleman Syndrome.
Topics: Anticonvulsants; Cannabidiol; Child; Clobazam; Clonazepam; Ethosuximide; Humans; Lamotrigine; Leveti | 2022 |
[Prospects for the development of new prolonged forms of valproic acid derivatives for the relief of convulsive syndrome].
Topics: Alcoholism; Anticonvulsants; Epilepsy; Humans; Seizures; Substance Withdrawal Syndrome; Valproic Aci | 2022 |
[Epilepsy in Angelman syndrome].
Topics: Angelman Syndrome; Anticonvulsants; Child; Electroencephalography; Epilepsy; Ethosuximide; Female; H | 2022 |
Valproate Teratogenicity: A Moving Target.
Topics: Abnormalities, Drug-Induced; Anticonvulsants; Epilepsy; Female; Humans; Pregnancy; Pregnancy Complic | 2022 |
Subcutaneous Levetiracetam and Sodium Valproate Use in Palliative Care Patients.
Topics: Anticonvulsants; Humans; Levetiracetam; Palliative Care; Piracetam; Retrospective Studies; Seizures; | 2022 |
Neural excitatory rebound induced by valproic acid may predict its inadequate control of seizures.
Topics: Animals; Anticonvulsants; China; Mice; Seizures; Status Epilepticus; Valproic Acid | 2022 |
Investigation into Antiepileptic Effect of Ganoderic Acid A and Its Mechanism in Seizure Rats Induced by Pentylenetetrazole.
Topics: Animals; Anticonvulsants; bcl-2-Associated X Protein; Caspase 3; Epilepsy; Heptanoic Acids; Lanoster | 2022 |
Epilepsy and pregnancy. Factors associated with epileptic seizures during pregnancy.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Humans; Lamotrigine; Levetiracetam; Pregnancy; Seizures; V | 2023 |
Psychomotor development and seizure features in idiopathic myoclonic epilepsy in infancy.
Topics: Electroencephalography; Epilepsies, Myoclonic; Humans; Retrospective Studies; Seizures; Valproic Aci | 2022 |
Effectiveness of Antiseizure Medication Duotherapies in Patients With Glioma: A Multicenter Observational Cohort Study.
Topics: Anticonvulsants; Cohort Studies; Glioma; Humans; Levetiracetam; Piracetam; Retrospective Studies; Se | 2022 |
Elevated photic response is followed by a rapid decay and depressed state in ictogenic networks.
Topics: Animals; Calcium; Epilepsy; Reproducibility of Results; Seizures; Valproic Acid; Zebrafish | 2022 |
Imatinib Attenuates Pentylenetetrazole Kindled and Pilocarpine Induced Recurrent Spontaneous Seizures in Mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Imatinib Mesylate; Mice; Pentylenetetraz | 2023 |
A heterozygous missense variant in the YWHAG gene causing developmental and epileptic encephalopathy 56 in a Chinese family.
Topics: 14-3-3 Proteins; China; Epilepsy; Heterozygote; Humans; Mutation, Missense; Seizures; Valproic Acid | 2022 |
A case of GFAP-IgG positivity followed by anti-NMDAR encephalitis.
Topics: Acyclovir; Anti-Inflammatory Agents; Anti-N-Methyl-D-Aspartate Receptor Encephalitis; Autoantibodies | 2022 |
Efficacy of antiseizure medication in a mouse model of HCN1 developmental and epileptic encephalopathy.
Topics: Animals; Anticonvulsants; Epilepsy; Epilepsy, Generalized; Hyperpolarization-Activated Cyclic Nucleo | 2023 |
Overexpression of Homer1b/c induces valproic acid resistance in epilepsy.
Topics: Animals; Anticonvulsants; Epilepsy; Mice; Pentylenetetrazole; Rats; Receptor, Metabotropic Glutamate | 2023 |
The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure.
Topics: Animals; Ankyrins; Anticonvulsants; Epilepsy; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; TRPA | 2023 |
The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure.
Topics: Animals; Ankyrins; Anticonvulsants; Epilepsy; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; TRPA | 2023 |
The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure.
Topics: Animals; Ankyrins; Anticonvulsants; Epilepsy; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; TRPA | 2023 |
The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure.
Topics: Animals; Ankyrins; Anticonvulsants; Epilepsy; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; TRPA | 2023 |
The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure.
Topics: Animals; Ankyrins; Anticonvulsants; Epilepsy; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; TRPA | 2023 |
The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure.
Topics: Animals; Ankyrins; Anticonvulsants; Epilepsy; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; TRPA | 2023 |
The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure.
Topics: Animals; Ankyrins; Anticonvulsants; Epilepsy; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; TRPA | 2023 |
The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure.
Topics: Animals; Ankyrins; Anticonvulsants; Epilepsy; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; TRPA | 2023 |
The blockade of transient receptor potential ankyrin 1 (TRPA1) protects against PTZ-induced seizure.
Topics: Animals; Ankyrins; Anticonvulsants; Epilepsy; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; TRPA | 2023 |
Effect of valproate on sleep patterns disturbed by epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Pentylenetetrazole; Quality of Life; Rat | 2023 |
Effect of valproate on sleep patterns disturbed by epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Pentylenetetrazole; Quality of Life; Rat | 2023 |
Effect of valproate on sleep patterns disturbed by epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Pentylenetetrazole; Quality of Life; Rat | 2023 |
Effect of valproate on sleep patterns disturbed by epilepsy.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Pentylenetetrazole; Quality of Life; Rat | 2023 |
How accurately do adult patients report their absence seizures?
Topics: Adult; Epilepsy, Absence; Female; Humans; Inpatients; Male; Seizures; Valproic Acid; Zonisamide | 2023 |
Antiseizure Effects of Scoparone, Borneol and Their Impact on the Anticonvulsant Potency of Four Classic Antiseizure Medications in the Mouse MES Model-An Isobolographic Transformation.
Topics: Animals; Anticonvulsants; Brain; Coumarins; Disease Models, Animal; Dose-Response Relationship, Drug | 2023 |
The Effect of Adenosine Signaling on Memory Impairment Induced by Pentylenetetrazole in Zebrafish.
Topics: Adenosine; Animals; Dipyridamole; Epilepsy; Pentylenetetrazole; Quality of Life; Seizures; Valproic | 2023 |
Effectiveness of Antiseizure Medication Triple Therapy in Patients With Glioma With Refractory Epilepsy: An Observational Cohort Study.
Topics: Anticonvulsants; Drug Resistant Epilepsy; Epilepsy, Generalized; Glioma; Humans; Retrospective Studi | 2023 |
Interaction of Varenicline with Classic Antiseizure Medications in the Mouse Maximal Electroshock-Induced Seizure Model.
Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, | 2023 |
Indications and prescribing patterns of antiseizure medications in children in New Zealand.
Topics: Adolescent; Anticonvulsants; Child; Databases, Factual; Female; Humans; Male; New Zealand; Retrospec | 2023 |
Maternal treatment with aripiprazole prevents the development of a valproic acid-induced autism-like phenotype in juvenile male mice.
Topics: Animals; Anticonvulsants; Aripiprazole; Autism Spectrum Disorder; Behavior, Animal; Disease Models, | 2023 |
A case of epilepsy with myoclonic atonic seizures caused by SLC6A1 gene mutation due to balanced chromosomal translocation.
Topics: Anticonvulsants; Child; Child, Preschool; Electroencephalography; Epilepsies, Myoclonic; Female; GAB | 2023 |
Efficacy and mechanisms of Dingxian pill combined with valproic acid on pentylenetetrazol-induced chronic epilepsy in rats.
Topics: Animals; Anticonvulsants; Epilepsy; Pentylenetetrazole; Rats; Seizures; Valproic Acid | 2023 |
Analysing patient-generated data to understand behaviours and characteristics of women with epilepsy of childbearing years: A prospective cohort study.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Death, Sudden; Epilepsy; Female; Humans; Middle Aged; Pros | 2023 |
Minimum effective sodium valproate dose in genetic generalized epilepsies.
Topics: Anticonvulsants; Drug-Related Side Effects and Adverse Reactions; Epilepsy, Generalized; Humans; Ret | 2023 |
The fate of spikes in self-limited epilepsy with centrotemporal spikes: Are clinical and baseline EEG features effective?
Topics: Electroencephalography; Epilepsy, Rolandic; Humans; Levetiracetam; Retrospective Studies; Seizures; | 2023 |
Acute pancreatitis during valproic acid administration in a patient with vascular dementia, epileptic seizures, and psychiatric symptoms: a case report.
Topics: Acute Disease; Aged; Amylases; Anticonvulsants; Dementia, Vascular; Epilepsy; Humans; Male; Pancreat | 2023 |
Risk of recurrence in patients with an unprovoked tonic-clonic seizure and generalized epileptiform discharges on EEG.
Topics: Adult; Electroencephalography; Epilepsy; Humans; Prospective Studies; Recurrence; Seizures; Valproic | 2023 |
Pharmacometabolic Effects of Pteryxin and Valproate on Pentylenetetrazole-Induced Seizures in Zebrafish Reveal Vagus Nerve Stimulation.
Topics: Acetylcholine; Animals; Anticonvulsants; Choline; Humans; Pentylenetetrazole; Seizures; Serotonin; T | 2023 |
Dynamic effects of miR-20a-5p on hippocampal ripple energy after status epilepticus in rats.
Topics: Animals; Chloral Hydrate; Hippocampus; MicroRNAs; Pilocarpine; Rats; Seizures; Status Epilepticus; V | 2023 |
Treatment of drop attacks: Anti-seizure drug choices of pediatric neurologists in Saudi Arabia.
Topics: Anticonvulsants; Child; Cross-Sectional Studies; Humans; Levetiracetam; Male; Neurologists; Saudi Ar | 2023 |
[Safe and Effective Management of Epilepsy in Pregnancy].
Topics: Anticonvulsants; Epilepsy; Female; Humans; Levetiracetam; Pregnancy; Seizures; Valproic Acid | 2023 |
Potassium Channel Subfamily T Member 1(KCNT1) Pathological Variant Causing Epilepsy Of Infancy With Migrating Focal Seizures: A Case Report.
Topics: Cyanosis; Epilepsy; Humans; Infant; Male; Nerve Tissue Proteins; Potassium Channels; Potassium Chann | 2023 |
Long-lasting antiseizure effects of chronic intrasubthalamic convection-enhanced delivery of valproate.
Topics: Animals; Convection; Membrane Potentials; Rats; Rats, Wistar; Seizures; Valproic Acid | 2023 |
Changes over 24 years in a pregnancy register - Teratogenicity and epileptic seizure control.
Topics: Anticonvulsants; Australia; Epilepsy; Female; Humans; Lamotrigine; Pregnancy; Pregnancy Complication | 2023 |
Idiopathic generalized epilepsy with phantom absences, absence status, and generalized tonic-clonic seizures: A case report.
Topics: Adult; Electroencephalography; Epilepsy, Absence; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Fem | 2023 |
Elevated serum alkaline phosphatase in epilepsy: effect of age and treatment.
Topics: Adolescent; Adult; Age Factors; Alkaline Phosphatase; Anticonvulsants; Carbamazepine; Child; Child, | 2020 |
N-Benzyl-(2,5-dioxopyrrolidin-1-yl)propanamide (AS-1) with Hybrid Structure as a Candidate for a Broad-Spectrum Antiepileptic Drug.
Topics: Animals; Anticonvulsants; Behavior, Animal; Dose-Response Relationship, Drug; Epilepsy; Ethosuximide | 2020 |
Sodium Valproate Reduces Neuronal Apoptosis in Acute Pentylenetetrzole-Induced Seizures via Inhibiting ER Stress.
Topics: Animals; Anticonvulsants; Apoptosis; Cinnamates; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Re | 2019 |
Bilateral acute angle closure as presenting feature of Drug Rash with Eosinophilia and Systemic Symptoms (DRESS).
Topics: Acute Disease; Adult; Anterior Eye Segment; Anticonvulsants; Carbamazepine; Drug Hypersensitivity Sy | 2019 |
[Epilepsy in children with congenital hemiparesis secondary to perinatal ictus].
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Female; Humans; Infan | 2019 |
Perampanel-induced hair curling in a patient with epilepsy associated with Pitt Hopkins syndrome.
Topics: Adolescent; Anticonvulsants; Epilepsy; Facies; Female; Hair; Humans; Hyperventilation; Intellectual | 2019 |
Evaluation of sodium valproate loaded nanoparticles in acute and chronic pentylenetetrazole induced seizure models.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Epilepsy; Maze Learning; Oxidative Stress; Pentyle | 2019 |
Long-term safety, tolerability, and efficacy of magnesium valproate versus sodium valproate in acute seizures.
Topics: Acute Disease; Adult; Aged; Anticonvulsants; Female; Humans; Male; Middle Aged; Seizures; Valproic A | 2020 |
Doing without valproate in women of childbearing potential with idiopathic generalized epilepsy: Implications on seizure outcome.
Topics: Adolescent; Adult; Anticonvulsants; Drug Substitution; Epilepsy, Generalized; Female; Humans; Retros | 2020 |
Anti-epileptic drug and folic acid usage during pregnancy, seizure and malformation outcomes: Changes over two decades in the Kerala Registry of Epilepsy and Pregnancy.
Topics: Adult; Anticonvulsants; Carbamazepine; Female; Folic Acid; Humans; India; Lamotrigine; Levetiracetam | 2020 |
Treatment decisions in women of childbearing age on valproate.
Topics: Adult; Anticonvulsants; Decision Making; Epilepsy; Female; Humans; Informed Consent; Patient Educati | 2020 |
Generalised tonic-clonic seizures on the subtherapeutic dose of olanzapine.
Topics: Administration, Intravenous; Aged; Anticonvulsants; Antipsychotic Agents; Bipolar Disorder; Drug Mon | 2019 |
ATP1A3-related epilepsy: Report of seven cases and literature-based analysis of treatment response.
Topics: Adult; Anticonvulsants; Cerebellar Ataxia; Child; Dystonic Disorders; Epilepsy; Female; Hearing Loss | 2020 |
Tonic-clonic seizures in idiopathic generalized epilepsies: Prevalence, risk factors, and outcome.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Electroencephalography; Epilepsy, Generalized; | 2020 |
Long-term vigabatrin treatment modifies pentylenetetrazole-induced seizures in mice: focused on GABA brain concentration.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Brain; Clonazepam; Disease Models, Animal; D | 2020 |
Delirium Secondary to Lamotrigine Toxicity.
Topics: Adolescent; Adult; Aged; Delirium; Drug Interactions; Female; Humans; Lamotrigine; Male; Middle Aged | 2020 |
Improvement of epilepsy with lacosamide in a patient with ring chromosome 20 syndrome.
Topics: Anticonvulsants; Carbamazepine; Child; Electroencephalography; Epilepsy; Humans; Lacosamide; Lamotri | 2020 |
Pregnancy after valproate withdrawal-Fetal malformations and seizure control.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Australia; Epilepsy; Female; Humans; Pregnancy; | 2020 |
Rapid eye movement (REM) sleep and seizure control in idiopathic generalized epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Child; Cohort Studies; Egypt; Epilepsy, Generalized; Female; Fol | 2020 |
Rufinamide as add-on therapy in children with epileptic encephalopathies other than Lennox-Gastaut syndrome: A study of 34 patients.
Topics: Adolescent; Anticonvulsants; Argentina; Child; Child, Preschool; Drug Therapy, Combination; Epilepsy | 2020 |
Multinodular and vacuolating neuronal tumour of the cerebrum: an incidental diagnosis in a child presenting with absence seizures.
Topics: Anticonvulsants; Brain Neoplasms; Child; Diagnosis, Differential; Ganglioneuroma; Humans; Magnetic R | 2021 |
Effects of Diclofenac Versus Meloxicam in Pentylenetetrazol-Kindled Mice.
Topics: Animals; Anticonvulsants; Diclofenac; Epilepsy; Kindling, Neurologic; Male; Meloxicam; Mice; Pentyle | 2020 |
Antiepileptic drugs for acute encephalitic patients presented with seizure.
Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Female; Humans; Levetira | 2020 |
Sub-additive (antagonistic) interaction of lacosamide with lamotrigine and valproate in the maximal electroshock-induced seizure model in mice: an isobolographic analysis.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Drug | 2020 |
Valproate impact and sex-dependent seizure remission in patients with idiopathic generalized epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Epilepsy, Generalized; Female; Humans; Male; Middle Aged; Retros | 2020 |
Reversible Splenial Lesion Syndrome with Some Novel Causes and Clinical Manifestations.
Topics: Adult; Anticonvulsants; Brain Diseases; Carbamazepine; Causality; Corpus Callosum; Female; Headache; | 2020 |
Gaze-evoked nystagmus associated with valproic acid-induced lamotrigine toxicity.
Topics: Adult; Anticonvulsants; Epilepsy, Temporal Lobe; Female; Humans; Lamotrigine; Nystagmus, Pathologic; | 2020 |
Remedial dosing recommendations for delayed or missed doses of valproic acid in patients with epilepsy based on Monte Carlo simulations.
Topics: Adult; Aged; Anticonvulsants; Child; Child, Preschool; Drug Administration Schedule; Epilepsy; Femal | 2020 |
SLC6A1 G443D associated with developmental delay and epilepsy.
Topics: Child, Preschool; Developmental Disabilities; Epilepsy; Female; GABA Plasma Membrane Transport Prote | 2020 |
Antiseizure drug efficacy and tolerability in established and novel drug discovery seizure models in outbred vs inbred mice.
Topics: Animals; Animals, Outbred Strains; Anticonvulsants; Behavior, Animal; Brain; Carbamazepine; Cornea; | 2020 |
Eight years follow-up of a generalized epilepsy patient with eating-induced late-onset epileptic spasms and atypical absence with myoclonic jerks.
Topics: Adolescent; China; Clonazepam; Eating; Epilepsy, Generalized; Follow-Up Studies; Humans; Male; Myocl | 2021 |
Trends of anti-seizure medication use in pediatric patients in six cities in China from 2013 to 2018.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Child, Preschool; China; Epilepsy; Female; Humans | 2020 |
Synthesis, anticonvulsant, and antinociceptive activity of new 3-(3-methyl-2,5-dioxo-3-phenylpyrrolidin-1-yl)propanamides and 3-phenyl-butanamides.
Topics: Amides; Analgesics; Animals; Anticonvulsants; Disease Models, Animal; Electroshock; Male; Mice; Pain | 2021 |
Risk-benefit assessment of treatment of epileptic women of childbearing age with valproic acid.
Topics: Adolescent; Adult; Anticonvulsants; Epilepsy; Female; Humans; Middle Aged; Pregnancy; Risk Assessmen | 2020 |
Effects of SCN1A and SCN2A polymorphisms on responsiveness to valproic acid monotherapy in epileptic children.
Topics: Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Genotype; Humans; Male; NAV1.1 Voltage-G | 2020 |
Anticonvulsant Effectiveness and Neurotoxicity Profile of 4-butyl-5-[(4-chloro-2-methylphenoxy)methyl]-2,4-dihydro-3H-1,2,4-triazole-3-thione (TPL-16) in Mice.
Topics: Animals; Anticonvulsants; Carbamazepine; Drug Synergism; Male; Mice; Muscle Strength; Phenobarbital; | 2021 |
Risk factors of paradoxical reactions to anti-seizure medication in genetic generalized epilepsy.
Topics: Adult; Anticonvulsants; Epilepsy, Generalized; Humans; Lamotrigine; Levetiracetam; Myoclonic Epileps | 2021 |
Pharmacodynamic and pharmacokinetic interactions of hydroalcoholic leaf extract of Centella asiatica with valproate and phenytoin in experimental models of epilepsy in rats.
Topics: Adjuvants, Pharmaceutic; Animals; Anticonvulsants; Behavior, Animal; Centella; Cognitive Dysfunction | 2021 |
Acute and chronic treatment with moclobemide, a reversible MAO-inhibitor, potentiates the antielectroshock activity of conventional antiepileptic drugs in mice.
Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, | 2021 |
Knowledge of epilepsy among German pharmacists.
Topics: Anticonvulsants; Carbamazepine; Drug-Related Side Effects and Adverse Reactions; Epilepsy; Humans; L | 2021 |
First-line antiepileptic drug treatment in glioma patients with epilepsy: Levetiracetam vs valproic acid.
Topics: Adult; Anticonvulsants; Brain Neoplasms; Female; Glioma; Humans; Levetiracetam; Male; Middle Aged; R | 2021 |
Discontinuation of preventive antiepileptic drugs in patients with intracerebral hemorrhage.
Topics: Adult; Aged; Anticonvulsants; Cerebral Hemorrhage; Female; Humans; Male; Middle Aged; Retrospective | 2021 |
Unmasking the entity of 'drug-resistant' perioral myoclonia with absences: the twitches, darts and domes!
Topics: Adolescent; Child; Electroencephalography; Epilepsies, Myoclonic; Epilepsies, Partial; Epilepsy, Abs | 2021 |
Our reasons for converting to valproic acid treatment in female patients with genetic generalized epilepsy: a retrospective, single-centre study.
Topics: Adolescent; Anticonvulsants; Child; Electroencephalography; Epilepsy, Generalized; Female; Humans; R | 2022 |
ERK1/2 kinases and dopamine D2 receptors participate in the anticonvulsant effects of a new derivative of benzoylpyridine oxime and valproic acid.
Topics: Animals; Anticonvulsants; Cell Line, Tumor; Corpus Striatum; Electroshock; Extracellular Signal-Regu | 2021 |
Effect of fenfluramine on convulsive seizures in CDKL5 deficiency disorder.
Topics: Adolescent; Adult; Anticonvulsants; Child; Child, Preschool; Epilepsies, Myoclonic; Epilepsy, Tonic- | 2021 |
Valproate-induced fatal acute hyperammonaemia-related encephalopathy in late-onset ornithine transcarbamylase deficiency.
Topics: Adult; Brain Diseases; Humans; Hyperammonemia; Male; Ornithine Carbamoyltransferase Deficiency Disea | 2021 |
Association of UGT1A6 gene polymorphism with clinical outcome in pediatric epileptic patients on sodium valproate monotherapy.
Topics: Anticonvulsants; Child; Epilepsy; Humans; Polymorphism, Single Nucleotide; Seizures; Valproic Acid | 2021 |
Epileptic convulsions probably induced by desloratadine: a case report.
Topics: Anticonvulsants; Child; Epilepsy; Humans; Male; Seizures; Valproic Acid | 2023 |
Antiseizure Drug Levels in Children Aged 2-12 Years Presenting With Breakthrough Seizures: A Single Center Cross-sectional Study.
Topics: Anticonvulsants; Child; Cross-Sectional Studies; Humans; Pharmaceutical Preparations; Phenytoin; Sei | 2021 |
Initial levetiracetam versus valproate monotherapy in antiseizure medicine (ASM)-naïve pediatric patients with idiopathic generalized epilepsy with tonic-clonic seizures.
Topics: Anticonvulsants; Child; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; Humans; Infant; Levetiracetam | 2021 |
Post-stroke seizures: risk factors and management after ischemic stroke.
Topics: Aged; Epilepsy; Female; Humans; Infarction, Middle Cerebral Artery; Ischemic Stroke; Male; Middle Ag | 2023 |
[Response to perampanel in a patient with chronic post-hypoxic myoclonus].
Topics: Anticonvulsants; Carcinoma, Papillary; Clonazepam; Drug Therapy, Combination; Electroencephalography | 2021 |
Carbamazepine/oxcarbazepine and valproate have different effects on the electroconvulsive therapy seizure threshold.
Topics: Carbamazepine; Electroconvulsive Therapy; Humans; Oxcarbazepine; Seizures; Valproic Acid | 2021 |
Lacosamide Lowers Valproate and Levetiracetam Levels.
Topics: Acetamides; Adolescent; Anticonvulsants; Brain Neoplasms; Drug Interactions; Epilepsies, Partial; Hu | 2017 |
Early Lance-Adams syndrome after cardiac arrest: Prevalence, time to return to awareness, and outcome in a large cohort.
Topics: Adult; Aged, 80 and over; Anticonvulsants; Cardiopulmonary Resuscitation; Clonazepam; Drug Combinati | 2017 |
L-Carnitine supplementation to reverse hyperammonemia in a patient undergoing chronic valproic acid treatment: A case report.
Topics: Adult; Anticonvulsants; Carnitine; Female; Humans; Hyperammonemia; Seizures; Valproic Acid | 2017 |
Sodium Valproate as a Continuous Subcutaneous Infusion: A Case Series.
Topics: Adult; Aged; Anticonvulsants; Brain Neoplasms; Humans; Infusions, Subcutaneous; Middle Aged; Seizure | 2017 |
Treatment of refractory psychogenic polydipsia with lithium.
Topics: Antipsychotic Agents; Enzyme Inhibitors; Humans; Hyponatremia; Lithium; Male; Polydipsia, Psychogeni | 2017 |
Urine Incontinence Induced by Valproic Acid.
Topics: Anticonvulsants; Child; Child, Preschool; Female; Humans; Male; Seizures; Urinary Incontinence; Valp | 2017 |
Low risk of seizures with slow flumazenil infusion and routine anticonvulsant prophylaxis for high-dose benzodiazepine dependence.
Topics: Adolescent; Adult; Anti-Anxiety Agents; Anticonvulsants; Antidotes; Benzodiazepines; Female; Flumaze | 2017 |
The impact of valproic acid treatment on weight gain in pediatric patients with epilepsy.
Topics: Anticonvulsants; Child; Child, Preschool; Epilepsy; Female; Humans; Male; Seizures; Valproic Acid; W | 2022 |
Cytoprotective effects of diallyl trisulfide against valproate-induced hepatotoxicity: new anticonvulsant strategy.
Topics: Allyl Compounds; Animals; Anti-Inflammatory Agents; Anticonvulsants; Antioxidants; Apoptosis; Chemic | 2017 |
Lamotrigine Drug Interactions in Combination Therapy and the Influence of Therapeutic Drug Monitoring on Clinical Outcomes of Adult Patients.
Topics: Adult; Anticonvulsants; Carbamazepine; Clonazepam; Drug Interactions; Drug Monitoring; Drug Therapy, | 2017 |
Circadian variation in anticonvulsant activity of valproic acid in mice.
Topics: Animals; Anticonvulsants; Circadian Rhythm; Drug Administration Schedule; Male; Mice; Pentylenetetra | 2017 |
Valproic Acid Combined With Postcardiac Arrest Hypothermic-Targeted Temperature Management Prevents Delayed Seizures and Improves Survival in a Rat Cardiac Arrest Model.
Topics: Animals; Heart Arrest; Hypothermia, Induced; Male; Prospective Studies; Rats; Rats, Long-Evans; Seiz | 2017 |
Pharmacokinetic and pharmacodynamic interaction of hydroalcoholic extract of Ocimum sanctum with valproate.
Topics: Animals; Anticonvulsants; Antioxidants; Avoidance Learning; Cognition; Disease Models, Animal; Drug | 2017 |
Effects of spontaneous recurrent seizures on cognitive function via modulation of SNAREs expression.
Topics: Animals; Anticonvulsants; Cognition Disorders; Disease Models, Animal; Escape Reaction; Excitatory A | 2018 |
Calcitonin potentiates the anticonvulsant and antinociceptive effects of valproic acid and pregabalin in pentylenetetrazole-kindled mice.
Topics: Analgesics; Animals; Anticonvulsants; Brain; Calcitonin; Drug Synergism; gamma-Aminobutyric Acid; Mi | 2018 |
Anabolic steroid abuse: what shall it profit a man to gain muscle and suffer the loss of his brain?
Topics: Acute Disease; Adult; Anabolic Agents; Heparin; Humans; Magnetic Resonance Imaging; Male; Nandrolone | 2017 |
Sotalol enhances the anticonvulsant action of valproate and diphenylhydantoin in the mouse maximal electroshock model.
Topics: Animals; Anti-Arrhythmia Agents; Anticonvulsants; Avoidance Learning; Brain; Disease Models, Animal; | 2017 |
Micronization potentiates curcumin's anti-seizure effect and brings an important advance in epilepsy treatment.
Topics: Animals; Anticonvulsants; Biological Availability; Curcumin; Disease Models, Animal; Drug Compoundin | 2018 |
Observational multicentre study into the use of antiepileptic drugs in Spanish neurology consultations.
Topics: Adult; Anticonvulsants; Drug Therapy, Combination; Epilepsy; Female; Humans; Lamotrigine; Levetirace | 2020 |
Double cortex syndrome in a male patient without lissencephaly.
Topics: Adult; Anticonvulsants; Classical Lissencephalies and Subcortical Band Heterotopias; Electroencephal | 2020 |
Benign rolandic epilepsy and generalized paroxysms: A study of 13 patients.
Topics: Anticonvulsants; Brain; Child; Child, Preschool; Electroencephalography; Epilepsy, Rolandic; Female; | 2018 |
The protective effect of polyunsaturated fatty acid intake during pregnancy against embryotoxicity of sodium valproate in mice.
Topics: Animals; Anticonvulsants; Embryonic Development; Fatty Acids, Omega-3; Female; Fetal Diseases; Folic | 2018 |
[A nationwide multi-center questionnaire survey on the management and treatment of post-stroke seizure and epilepsy in Japan].
Topics: Anticonvulsants; Carbamazepine; Epilepsy; Female; Humans; Japan; Levetiracetam; Male; Piracetam; Sei | 2018 |
Effects of UGT2B7, SCN1A and CYP3A4 on the therapeutic response of sodium valproate treatment in children with generalized seizures.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Cytochrome P-450 CYP3A; Drug Resistant Epileps | 2018 |
Carbamazepine Verses Valproic Acid as Monotherapy in Epileptic Patients.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Chromatography, Liquid; Epilepsy; Female; | 2018 |
[Establish and use of an epilepsy model in larval zebrafish].
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Epilepsy; Larva; Nerve Tissue Proteins; Pen | 2016 |
Influenza B-related meningoencephalitis in adults.
Topics: Aged, 80 and over; Antiviral Agents; Betainfluenzavirus; Confusion; Humans; Influenza, Human; Leveti | 2018 |
Nonlesional late-onset epilepsy: Semiology, EEG, cerebrospinal fluid, and seizure outcome characteristics.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Electroencephalography; Epilepsy; Femal | 2019 |
First Molecular Diagnosis of a Patient with Unverricht-Lundborg Disease in Korea.
Topics: Adult; Anticonvulsants; Blotting, Southern; Cystatin B; Female; Genetic Predisposition to Disease; H | 2018 |
A cool side effect of valproic acid administration: Single dose-induced hypothermia.
Topics: Adult; Anticonvulsants; Humans; Hypothermia; Levetiracetam; Male; Phenytoin; Seizures; Valproic Acid | 2018 |
DSP-4 induced depletion of brain noradrenaline and increased 6-hertz psychomotor seizure susceptibility in mice is prevented by sodium valproate.
Topics: Animals; Anticonvulsants; Benzylamines; Brain; Disease Models, Animal; Disease Susceptibility; Drug | 2018 |
Pronounced antiepileptic activity of the subtype-selective GABA
Topics: Animals; Anticonvulsants; Diazepam; Dose-Response Relationship, Drug; Electrocorticography; Electrod | 2019 |
Valproate-associated foetal malformations-Rates of occurrence, risks in attempted avoidance.
Topics: Abnormalities, Drug-Induced; Adult; Anticonvulsants; Australia; Epilepsy; Female; Humans; Pregnancy; | 2019 |
Evaluation of ghrelin, nesfatin-1 and irisin levels of serum and brain after acute or chronic pentylenetetrazole administrations in rats using sodium valproate.
Topics: Animals; Anticonvulsants; Biomarkers; Brain; Calcium-Binding Proteins; Disease Models, Animal; DNA-B | 2018 |
A very rare interference with the valproate method on the Beckman DxC 800 general chemistry analyser.
Topics: Adult; Blood Chemical Analysis; Humans; Male; Seizures; Valproic Acid | 2019 |
[COMPARISON OF CHRONIC ANTICONVULSANT ACTIVITY AND SAFETY OF IEM-2062, SODIUM VALPROATE AND ME-MANTINE IN THE PENTYLENETETRAZOL KINDLING MODEL IN RATS].
Topics: Administration, Oral; Animals; Anticonvulsants; Convulsants; Cyclohexanes; Cyclohexylamines; Drug Ad | 2017 |
[Two cases of photosensitive seizure induced by barcode readers with red flashing lights].
Topics: Adult; Anticonvulsants; Consciousness Disorders; Durable Medical Equipment; Electroencephalography; | 2018 |
Effect of valproic acid alone or combined with low dose gamma irradiation in modulating PTZ-induced convulsions in rats involving AKT/m-TOR pathway.
Topics: Animals; Anticonvulsants; Convulsants; Gamma Rays; Gene Expression Regulation; Male; Pentylenetetraz | 2018 |
Asymptomatic malaria parasitaemia and seizure control in children with nodding syndrome; a cross-sectional study.
Topics: Adolescent; Anticonvulsants; Antiparasitic Agents; Child; Cross-Sectional Studies; Doxycycline; Fema | 2018 |
Adverse Effects of Treatment with Valproic Acid during the Neonatal Period.
Topics: Anticonvulsants; Chemical and Drug Induced Liver Injury; Consciousness Disorders; Female; Hematologi | 2019 |
Long-Term Safety, Tolerability, and Efficacy of Cannabidiol in Children with Refractory Epilepsy: Results from an Expanded Access Program in the US.
Topics: Adolescent; Anticonvulsants; Cannabidiol; Child; Child, Preschool; Drug Therapy, Combination; Epilep | 2019 |
Serotonergic mechanisms in the 6-Hz psychomotor seizures in mice.
Topics: Animals; Behavior, Animal; Cerebral Cortex; Disease Models, Animal; Electric Stimulation; Epilepsy, | 2019 |
A 33-Year-Old Woman With Altered Mental Status and Elevated Ammonia Level.
Topics: Adult; Ammonia; Anticonvulsants; Arrhythmias, Cardiac; Drug Overdose; Female; Glasgow Coma Scale; Hu | 2018 |
Influence of dronedarone (a class III antiarrhythmic drug) on the anticonvulsant potency of four classical antiepileptic drugs in the tonic-clonic seizure model in mice.
Topics: Animals; Anti-Arrhythmia Agents; Anticonvulsants; Behavior, Animal; Brain; Carbamazepine; Disease Mo | 2019 |
Anemia secondary to the use of sodium valproate for preventing postoperative seizures in a 79-year-old man: A case report.
Topics: Aged; Anemia; Anticonvulsants; Erythrocyte Transfusion; Humans; Liver Function Tests; Male; Neurosur | 2018 |
Lack of association between valproic acid response and polymorphisms of its metabolism, transport, and receptor genes in children with focal seizures.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Female; Gene Frequency; Genetic Association St | 2019 |
Accidental injuries in patients with generalized tonic-clonic seizures. A multicenter, observational, cross-sectional study (QUIN-GTC study).
Topics: Accidental Injuries; Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Cross-Sectional St | 2019 |
Effects of enalapril and losartan alone and in combination with sodium valproate on seizures, memory, and cardiac changes in rats.
Topics: Animals; Anticonvulsants; Drug Therapy, Combination; Enalapril; Heart Diseases; Kindling, Neurologic | 2019 |
Energy Drink-Induced Breakthrough Seizure in a Patient on Valproic Acid-Considering Herbal Safety in Epilepsy.
Topics: Adolescent; Anticonvulsants; Energy Drinks; Epilepsy; Herb-Drug Interactions; Humans; Male; Seizures | 2019 |
A Novel Protocol to Reduce Early Seizures After Cranioplasty: A Single-Center Experience.
Topics: Adult; Anticonvulsants; Clinical Protocols; Decompressive Craniectomy; Drug Administration Schedule; | 2019 |
AMPA receptor antagonist perampanel affects glioblastoma cell growth and glutamate release in vitro.
Topics: Anticonvulsants; Antineoplastic Agents; Apoptosis; Brain; Brain Neoplasms; Cell Line, Tumor; Cell Pr | 2019 |
An uncommon presentation of hyperhomocysteinemia and vitamin B
Topics: Adult; Anticoagulants; Anticonvulsants; Brain; Diuretics, Osmotic; Glycerol; Heparin; Humans; Hyperh | 2019 |
New derivative of 1,2,4-triazole-3-thione (TP427) potentiates the anticonvulsant action of valproate, but not that of carbamazepine, phenytoin or phenobarbital in the mouse tonic-clonic seizure model.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Drug Interactions; Drug Synergism; | 2019 |
Comparison of valproate and levetiracetam for the prevention of busulfan-induced seizures in hematopoietic stem cell transplantation.
Topics: Adult; Aged; Anticonvulsants; Busulfan; Female; Hematopoietic Stem Cell Transplantation; Humans; Imm | 2019 |
Unverricht-Lundborg disease: Clinical course and seizure management based on the experience of polish centers.
Topics: Adult; Anticonvulsants; Brain; Electroencephalography; Female; Humans; Magnetic Resonance Imaging; M | 2019 |
A case of early myoclonic encephalopathy with intractable seizures successfully treated with high-dose phenobarbital.
Topics: Anticonvulsants; Electroencephalography; Epilepsies, Myoclonic; Humans; Infant; Male; Phenobarbital; | 2019 |
The effect of co-administration of pentylenetetrazole with pilocarpine: New modified PTZ models of kindling and seizure.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Drug Resistance; Epilepsy; Kindling, | 2019 |
Levetiracetam Protects Against Cognitive Impairment of Subthreshold Convulsant Discharge Model Rats by Activating Protein Kinase C (PKC)-Growth-Associated Protein 43 (GAP-43)-Calmodulin-Dependent Protein Kinase (CaMK) Signal Transduction Pathway.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cognitive Dysfunction; Disease Models, Animal | 2019 |
Drug interactions are not always predictable: the curious case of valproic acid and dolutegravir and a possible explanation.
Topics: Adult; Anticonvulsants; Blood Chemical Analysis; Drug Interactions; Female; Heterocyclic Compounds, | 2019 |
Acquired epileptiform opercular syndrome evaluated with real-time transcranial Doppler ultrasound-video-electroencephalogram before and after treatment: a case report.
Topics: Anticonvulsants; Child, Preschool; Electroencephalography; Humans; Male; Methylprednisolone; Seizure | 2019 |
ARX-associated infantile epileptic-dyskinetic encephalopathy with responsiveness to valproate for controlling seizures and reduced activity of muscle mitochondrial complex IV.
Topics: Adolescent; Adult; Asian People; China; Cytochrome-c Oxidase Deficiency; Dystonic Disorders; Epileps | 2019 |
Association of antiepileptic drugs with resolution of epileptiform activity after cardiac arrest.
Topics: Anticonvulsants; Cohort Studies; Coma; Combined Modality Therapy; Electroencephalography; Female; He | 2019 |
Treatment and challenges with antiepileptic drugs in patients with juvenile myoclonic epilepsy.
Topics: Adolescent; Adult; Anticonvulsants; Cohort Studies; Female; Humans; Lamotrigine; Levetiracetam; Male | 2019 |
Syntheses of Benzo[
Topics: Animals; Antarctic Regions; Anticonvulsants; Antidepressive Agents; Aquatic Organisms; Benzothiazole | 2019 |
A 16q22.2-q23.1 deletion identified in a male infant with West syndrome.
Topics: Anticonvulsants; Chromosomes, Human, Pair 16; Epilepsy; Humans; Infant; Intellectual Disability; Lam | 2019 |
Effects of Three Anti-Seizure Drugs on Cholinergic and Metabolic Activity in Experimental Status Epilepticus.
Topics: Acetylcholine; Animals; Anticonvulsants; Behavior, Animal; Cholinergic Agents; Chromatography, High | 2019 |
Epilepsy in patients with Cornelia de Lange syndrome: a clinical series.
Topics: Adolescent; Carbamazepine; Child; Child, Preschool; De Lange Syndrome; Electroencephalography; Epile | 2013 |
Valproic acid use during radiation therapy for glioblastoma associated with improved survival.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Antineoplastic Agents, Alkylating; Brain Neoplasms; Combin | 2013 |
[The syndrome of malignant migrating partial seizures in infancy or Coppola-Dulac syndrome (19 cases)].
Topics: Anticonvulsants; Disease Progression; Electroencephalography; Epilepsies, Partial; Female; Follow-Up | 2013 |
Effect of valproic acid on seizure control and on survival in patients with glioblastoma multiforme.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Antineoplastic Agents, Alkylating; Brain Neoplasms; | 2013 |
[Comparison of neuroprotective effects of anticonvulsant drugs in brain injury therapy].
Topics: Amines; Animals; Animals, Outbred Strains; Anticonvulsants; Brain; Brain Injuries; Brain Ischemia; C | 2012 |
ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays antiepileptic properties in mice.
Topics: Animals; Anticonvulsants; Calcium Signaling; Dose-Response Relationship, Drug; Drug Evaluation, Prec | 2013 |
[A paradoxical reaction on valproates in a female patient with juvenile absence epilepsy].
Topics: Adult; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Therapy, Combination; | 2013 |
Clinical experience with intravenous valproate as first-line treatment of status epilepticus and seizure clusters in selected populations.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Electroencephalography; Female; Humans; Injections, Intrav | 2014 |
Are we ready for a randomized trial of valproic acid in newly diagnosed glioblastoma?
Topics: Anticonvulsants; Brain Neoplasms; Female; Glioblastoma; Humans; Levetiracetam; Male; Neoplasm Recurr | 2013 |
Derivatives of valproic acid are active against pentetrazol-induced seizures in immature rats.
Topics: Aging; Allylisopropylacetamide; Amides; Animals; Anticonvulsants; Convulsants; Epilepsy, Generalized | 2013 |
Seizure control and treatment changes in pregnancy: observations from the EURAP epilepsy pregnancy registry.
Topics: Anticonvulsants; Carbamazepine; Female; Humans; Lamotrigine; Phenobarbital; Pregnancy; Pregnancy Com | 2013 |
Stiripentol in Dravet syndrome: results of a retrospective U.S. study.
Topics: Anticonvulsants; Benzodiazepines; Child; Child, Preschool; Clobazam; Dioxolanes; Drug Therapy, Combi | 2013 |
Myoclonic epilepsy in infancy: an electroclinical study and long-term follow-up of 38 patients.
Topics: Anticonvulsants; Child, Preschool; Electroencephalography; Epilepsies, Myoclonic; Female; Follow-Up | 2013 |
Levetiracetam compared with valproic acid for the prevention of postoperative seizures after supratentorial tumor surgery: a retrospective chart review.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Brain Neoplasms; Child; Child, Preschoo | 2013 |
Seizures from valproate-carbapenem interaction.
Topics: Adolescent; Anticonvulsants; Carbapenems; Drug Interactions; Female; Humans; Seizures; Valproic Acid | 2013 |
Seizure-sensitivity in Drosophila is ameliorated by dorsal vessel injection of the antiepileptic drug valproate.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Drosophila melanogaster; Injections, Intra-Arteria | 2013 |
Valnoctamide and sec-butyl-propylacetamide (SPD) for acute seizures and status epilepticus.
Topics: Acute Disease; Amides; Animals; Anticonvulsants; Disease Models, Animal; Guinea Pigs; Humans; Rats; | 2013 |
Drug screening in Scn1a zebrafish mutant identifies clemizole as a potential Dravet syndrome treatment.
Topics: Animals; Anticonvulsants; Benzimidazoles; Bromides; Diazepam; Dioxolanes; Drug Evaluation, Preclinic | 2013 |
Long-term valproate treatment increases brain neuropeptide Y expression and decreases seizure expression in a genetic rat model of absence epilepsy.
Topics: Animals; Anticonvulsants; Brain; Epilepsy, Absence; Male; Neuropeptide Y; Rats; Rats, Wistar; Seizur | 2013 |
SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties.
Topics: Actin-Related Protein 2-3 Complex; Actins; Adult; Animals; Behavior, Animal; Bipolar Disorder; Chrom | 2013 |
Early-onset absence epilepsy aggravated by valproic acid: a video-EEG report.
Topics: Age of Onset; Anticonvulsants; Child, Preschool; Electroencephalography; Epilepsy, Absence; Humans; | 2013 |
Impact of planning of pregnancy in women with epilepsy on seizure control during pregnancy and on maternal and neonatal outcomes.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Anticonvulsants; Epilepsy; Female; Humans; Pregnancy | 2014 |
Evaluation of anti-epileptic property of Marsilea quadrifolia Linn. in maximal electroshock and pentylenetetrazole-induced rat models of epilepsy.
Topics: Animals; Convulsants; Disease Models, Animal; Electroshock; Epilepsy; Male; Marsileaceae; Pentylenet | 2013 |
Antiepileptic drug utilization in Bangladesh: experience from Dhaka Medical College Hospital.
Topics: Adolescent; Adult; Anticonvulsants; Bangladesh; Carbamazepine; Child; Drug Combinations; Epilepsies, | 2013 |
Is coloboma a feature of fetal valproate syndrome?
Topics: Abnormalities, Drug-Induced; Child, Preschool; Coloboma; Humans; Male; Seizures; Valproic Acid | 2014 |
[Valproate-induced hyperammonemic encephalopathy in a neonate: treatment with carglumic acid].
Topics: Anticonvulsants; Glutamates; Humans; Hyperammonemia; Infant, Newborn; Male; Neurotoxicity Syndromes; | 2014 |
Low-dose sodium valproate in the treatment of idiopathic generalized epilepsies.
Topics: Adult; Anticonvulsants; Epilepsy, Absence; Epilepsy, Generalized; Female; Follow-Up Studies; Humans; | 2014 |
[Combined blockade of AMPA- and NMDA-receptors has maximum effect to eliminate development of pentylenetetrazole-induced kindling in rats].
Topics: Adamantane; Administration, Oral; Animals; Anticonvulsants; Drug Administration Schedule; Male; Pent | 2013 |
Neck myoclonia with absence seizures in an Indian girl.
Topics: Anticonvulsants; Benzodiazepines; Brain; Child; Clobazam; Electroencephalography; Epilepsies, Myoclo | 2014 |
Lacosamide serum concentrations in adult patients with epilepsy: the influence of gender, age, dose, and concomitant antiepileptic drugs.
Topics: Acetamides; Adult; Aged; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Inte | 2014 |
[Clinical efficacy and pharmacokinetics of lamotrigine for childhood-onset intractable epilepsy].
Topics: Adolescent; Age of Onset; Child; Drug Therapy, Combination; Female; Humans; Lamotrigine; Male; Seizu | 2014 |
Measurement of levetiracetam drug levels to assist with seizure control and monitoring of drug interactions with other anti-epileptic medications (AEMs).
Topics: Adult; Aged; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Interactions; Dr | 2014 |
[Effect of capecitabine therapy on the blood levels of antiepileptic drugs - report of two cases].
Topics: Anticonvulsants; Antimetabolites, Antineoplastic; Brain Neoplasms; Breast Neoplasms; Capecitabine; D | 2014 |
Effect of quercetin and rutin in some acute seizure models in mice.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Ther | 2014 |
Raloxifene preserves phenytoin and sodium valproate induced bone loss by modulating serum estradiol and TGF-β3 content in bone of female mice.
Topics: Animals; Anticonvulsants; Bone and Bones; Bone Density; Bone Density Conservation Agents; Bone Disea | 2014 |
Hypokalemia and hypomagnesaemia related to levetiracetam use.
Topics: Adult; Anticonvulsants; Humans; Hypokalemia; Lamotrigine; Levetiracetam; Magnesium; Male; Nephritis, | 2014 |
Depression and seizures as the main neuropsychiatric manifestation of mixed connective tissue disorder.
Topics: Adult; Antibodies, Antinuclear; Anticonvulsants; Antidepressive Agents, Second-Generation; Azathiopr | 2014 |
Histamine H3 receptor antagonism by ABT-239 attenuates kainic acid induced excitotoxicity in mice.
Topics: Animals; Anticonvulsants; Benzofurans; Dose-Response Relationship, Drug; Drug Therapy, Combination; | 2014 |
[Not to forget interaction between meropenem and valproic acid].
Topics: Aged, 80 and over; Anti-Bacterial Agents; Anticonvulsants; Drug Interactions; Female; Humans; Merope | 2014 |
Serial EEG study in a girl with Landau-Kleffner syndrome associated with continuous spikes and waves during slow sleep.
Topics: Anticonvulsants; Brain; Carbamazepine; Electroencephalography; Female; Humans; Infant; Landau-Kleffn | 2014 |
Valproate-induced pseudoatrophy: expanding the clinical and imaging spectrum.
Topics: Anticonvulsants; Atrophy; Brain; Child; Cognition Disorders; Humans; Magnetic Resonance Imaging; Mag | 2014 |
Synthesis, physicochemical, and anticonvulsant properties of new N-Mannich bases derived from pyrrolidine-2,5-dione and its 3-methyl analog.
Topics: Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug | 2014 |
Treatment gaps of epilepsy and retention rates of sodium valproate in rural Guangxi, China.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Child; China; Epilepsies, Partial; Epilepsy, Absence; Fema | 2014 |
Validation of a multigenic model to predict seizure control in newly treated epilepsy.
Topics: Adult; Algorithms; Anticonvulsants; Artificial Intelligence; Australia; Biomarkers, Pharmacological; | 2014 |
[Convulsions due to an interaction between anti-epileptic drugs and rifampicin].
Topics: Anticonvulsants; Carbamazepine; Clonazepam; Cytochrome P-450 Enzyme System; Drug Interactions; Epile | 2014 |
Haematological toxicity of Valproic acid compared to Levetiracetam in patients with glioblastoma multiforme undergoing concomitant radio-chemotherapy: a retrospective cohort study.
Topics: Adult; Aged; Anticonvulsants; Blood Cell Count; Blood Cells; Brain Neoplasms; Chemoradiotherapy; Fem | 2015 |
First case report of suspected onset of convulsive seizures due to co-administration of valproic acid and tebipenem.
Topics: Anti-Bacterial Agents; Anticonvulsants; Carbapenems; Child; Drug Interactions; Drug Monitoring; Huma | 2015 |
Low dose zinc supplementation beneficially affects seizure development in experimental seizure models in rats.
Topics: Animals; Anticonvulsants; Dietary Supplements; Disease Models, Animal; Male; Phenytoin; Rats; Rats, | 2015 |
Inter-individual variation in the effect of antiepileptic drugs in the intrahippocampal kainate model of mesial temporal lobe epilepsy in mice.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Drug Resistance; Electrod | 2015 |
[Stimulation of gastric mucosa afferents by phenylephrine potentiates anticonvulsive and eliminates sedative action of sodium valproate in the pentylenetetrazol kindling model in rats].
Topics: Afferent Pathways; Animals; Anticonvulsants; Behavior, Animal; Dose-Response Relationship, Drug; Dru | 2014 |
Ammonia encephalopathy and awake craniotomy for brain language mapping: cause of failed awake craniotomy.
Topics: Anesthesia, General; Anesthesia, Local; Anticonvulsants; Aphasia; Benzodiazepines; Brain Diseases; B | 2015 |
LAMA2-related congenital muscular dystrophy complicated by West syndrome.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Brain; Child, Preschool; Electroencephalography; Human | 2015 |
A new model to study sleep deprivation-induced seizure.
Topics: Aging; Animals; Anticonvulsants; Disease Models, Animal; Disease Susceptibility; Drosophila melanoga | 2015 |
Efficacy and tolerability of the ketogenic diet in Dravet syndrome - Comparison with various standard antiepileptic drug regimen.
Topics: Adolescent; Anticonvulsants; Benzodiazepines; Bromides; Child; Child, Preschool; Clobazam; Diet, Ket | 2015 |
Impaired sleep-related consolidation of declarative memories in idiopathic focal epilepsies of childhood.
Topics: Anticonvulsants; Child; Electroencephalography; Epilepsies, Partial; Epilepsy, Rolandic; Female; Hum | 2015 |
Pharmacological interaction between valproic acid and carbapenem: what about levels in pediatrics?
Topics: Adolescent; Anticonvulsants; Carbapenems; Child; Child, Preschool; Drug Interactions; Drug Therapy, | 2015 |
Standard dose valproic acid does not cause additional cognitive impact in a rodent model of intractable epilepsy.
Topics: Animals; Animals, Newborn; Anticonvulsants; Cognition; Cognition Disorders; Disease Models, Animal; | 2015 |
Modafinil and its metabolites enhance the anticonvulsant action of classical antiepileptic drugs in the mouse maximal electroshock-induced seizure model.
Topics: Animals; Anticonvulsants; Avoidance Learning; Benzhydryl Compounds; Brain; Carbamazepine; Central Ne | 2015 |
Valproate-induced neurodevelopmental deficits in Xenopus laevis tadpoles.
Topics: Animals; Animals, Genetically Modified; Anticonvulsants; Avoidance Learning; Convulsants; Dendrites; | 2015 |
A child with ictal vocalizations and generalized epilepsy.
Topics: Adolescent; Anticonvulsants; Electroencephalography; Epilepsy, Generalized; Epilepsy, Tonic-Clonic; | 2015 |
Antiepileptic prophylaxis following severe traumatic brain injury within a military cohort.
Topics: Adult; Anticonvulsants; Brain Injuries; Carbamazepine; Case-Control Studies; Chemoprevention; Cohort | 2016 |
Cross-species pharmacological characterization of the allylglycine seizure model in mice and larval zebrafish.
Topics: Allylglycine; Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Fructose; Levetiracetam; M | 2015 |
Pharmacodynamic and pharmacokinetic analysis of CNS-active constitutional isomers of valnoctamide and sec-butylpropylacetamide--Amide derivatives of valproic acid.
Topics: Amides; Animals; Anticonvulsants; Female; Isomerism; Male; Mice; Mice, Transgenic; Rats; Rats, Sprag | 2015 |
Evaluation of the efficacy of sodium valproate in convulsive status epilepticus following to ıschemic stroke.
Topics: Administration, Intravenous; Age Factors; Aged; Aged, 80 and over; Anticonvulsants; Female; Humans; | 2015 |
Synergistic effect of docosahexaenoic acid on anticonvulsant activity of valproic acid and lamotrigine in animal seizure models.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Docosahexaenoic Acids; Dose-Response Relationship, | 2015 |
Effect of xanthotoxin (8-methoxypsoralen) on the anticonvulsant activity of classical antiepileptic drugs against maximal electroshock-induced seizures in mice.
Topics: Animals; Anticonvulsants; Carbamazepine; Drug Synergism; Electroshock; Male; Methoxsalen; Mice; Phen | 2015 |
Comparative Long-Term Effectiveness of a Monotherapy with Five Antiepileptic Drugs for Focal Epilepsy in Adult Patients: A Prospective Cohort Study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Epilepsies, Partial; Fem | 2015 |
Efficacy of phenytoin, valproic acid, carbamazepine and new antiepileptic drugs on control of late-onset post-stroke epilepsy in Taiwan.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Cohort Studies; Female; Humans; Male | 2015 |
Recurrent seizures during acute acquired toxoplasmosis in an immunocompetent traveller returning from Africa.
Topics: Adolescent; Antibodies, Protozoan; Anticonvulsants; Antiprotozoal Agents; Epilepsy; Ethiopia; Humans | 2016 |
Pediatric Herpes Simplex Virus Encephalitis Complicated by N-Methyl-D-aspartate Receptor Antibody Encephalitis.
Topics: Acyclovir; Anti-N-Methyl-D-Aspartate Receptor Encephalitis; Antiviral Agents; Autoantibodies; Clonid | 2015 |
Reduction of epileptiform activity through local valproate-implants in a rat neocortical epilepsy model.
Topics: Animals; Anticonvulsants; Cobalt; Disease Models, Animal; Drug Implants; Electrocorticography; Elect | 2015 |
Epileptogenesis and epileptic maturation in phosphorylation site-specific SNAP-25 mutant mice.
Topics: Animals; Anticonvulsants; Anxiety; Blotting, Western; Brain; Disease Progression; Electrocorticograp | 2015 |
Ketogenic diet prevents epileptogenesis and disease progression in adult mice and rats.
Topics: Adenosine; Animals; Anticonvulsants; Diet, Ketogenic; Disease Models, Animal; Disease Progression; D | 2015 |
M-current preservation contributes to anticonvulsant effects of valproic acid.
Topics: A Kinase Anchor Proteins; Action Potentials; Animals; Anthracenes; Anticonvulsants; Carbamates; Cell | 2015 |
Repackaged sodium valproate tablets--Meeting quality and adherence to ensure seizure control.
Topics: Anticonvulsants; Chromatography, High Pressure Liquid; Drug Packaging; Drug Stability; Drug Storage; | 2015 |
Landau-Kleffner syndrome: an uncommon dealt with case in Southeast Asia.
Topics: Anticonvulsants; Aphasia; Asia, Southeastern; Child; Electroencephalography; Humans; Landau-Kleffner | 2015 |
Modulation of brain glutamate dehydrogenase as a tool for controlling seizures.
Topics: Animals; Anticonvulsants; Brain; Deamination; Diazepam; Disease Models, Animal; Enzyme Inhibitors; G | 2015 |
Pharmacokinetics and Clinical Utility of Valproic Acid Administered via Continuous Infusion.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Child; Child, Preschool; Cohort Studies | 2016 |
Mexiletine and its Interactions with Classical Antiepileptic Drugs: An Isobolographic Analysis.
Topics: Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Drug Interactions; Electroshock; | 2016 |
Antiepileptic Activity of a New Derivative of Benzimidazole RU-1205.
Topics: Animals; Anticonvulsants; Benzimidazoles; Kindling, Neurologic; Male; Mice; Morpholines; Pentylenete | 2016 |
Sodium valproate-induced Fanconi type proximal renal tubular acidosis.
Topics: Acidosis, Renal Tubular; Anticonvulsants; Child; Child, Preschool; Diagnosis, Differential; Fanconi | 2016 |
Synthesis and Evaluation of Phenyliminoindolin-Containing Phenylacetamide Derivatives with the Antidepressant and Anticonvulsant Effects.
Topics: Acetanilides; Animals; Anticonvulsants; Antidepressive Agents; Dopamine; Electroshock; Fluoxetine; H | 2016 |
Anticonvulsant Effects of Combined Treatment with Citicoline and Valproate on the Model of Acute Generalized Convulsions Induced by Pentylenetetrazole in Wistar Rats.
Topics: Animals; Anticonvulsants; Cytidine Diphosphate Choline; Disease Models, Animal; Drug Therapy, Combin | 2016 |
Aggravation of atonic seizures by rufinamide: A case report.
Topics: Anticonvulsants; Benzodiazepines; Brain; Child; Clobazam; Drug Resistant Epilepsy; Drug Therapy, Com | 2016 |
The effects of cimetidine chronic treatment on conventional antiepileptic drugs in mice.
Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Cimetidine; Drug Interactions; Electroshock; Male; M | 2016 |
Evaluation of the pentylenetetrazole seizure threshold test in epileptic mice as surrogate model for drug testing against pharmacoresistant seizures.
Topics: Animals; Anticonvulsants; Diazepam; Disease Models, Animal; Drug Resistance; Epilepsy; GABA Antagoni | 2016 |
Tonic Seizure Status Epilepticus Triggered by Valproate in a Child with Doose Syndrome.
Topics: Anticonvulsants; Child; Electroencephalography; Epilepsies, Myoclonic; Humans; Male; Seizures; Statu | 2016 |
Does valproic acid affect tumor growth and improve survival in glioblastomas?
Topics: Anticonvulsants; Antineoplastic Agents, Alkylating; Brain Neoplasms; Cell Differentiation; Cell Prol | 2016 |
Epigenetic Downregulation of Scn3a Expression by Valproate: a Possible Role in Its Anticonvulsant Activity.
Topics: Alpha-Ketoglutarate-Dependent Dioxygenase FTO; Animals; Anticonvulsants; Cell Line, Tumor; CpG Islan | 2017 |
The relationship between valproate induced tremors and circulating neurotransmitters: a preliminary study.
Topics: Adult; Anticonvulsants; Female; Humans; Male; Middle Aged; Neurotransmitter Agents; Seizures; Statis | 2017 |
Differential impact of contraceptive methods on seizures varies by antiepileptic drug category: Findings of the Epilepsy Birth Control Registry.
Topics: Adult; Anticonvulsants; Contraception; Contraceptive Agents; Contraceptives, Oral, Hormonal; Epileps | 2016 |
Synthesis and Anticonvulsant Activity of N-(Substituted)-1-methyl-2,4-dioxo-1,2-dihydroquinazoline-3(4H)-carboxamides.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroshock; Methaqualone; Mice; Pentyl | 2016 |
Seizures triggered by pentylenetetrazol in marmosets made chronically epileptic with pilocarpine show greater refractoriness to treatment.
Topics: Animals; Anticonvulsants; Brain; Callithrix; Carbamazepine; Chronic Disease; Disease Models, Animal; | 2016 |
Evidence in support of using a neurochemistry approach to identify therapy for both epilepsy and associated depression.
Topics: Animals; Anticonvulsants; Brain; Depression; Depressive Disorder; Disease Models, Animal; Dopamine; | 2016 |
Electroclinical aspects and therapy of Han patients with juvenile myoclonic epilepsy in northern China.
Topics: Adolescent; Adult; Anticonvulsants; Brain; Child; Child, Preschool; China; Electroencephalography; F | 2016 |
Agmatine rescues autistic behaviors in the valproic acid-induced animal model of autism.
Topics: Agmatine; Animals; Autism Spectrum Disorder; Disease Models, Animal; Grooming; Hippocampus; Hyperkin | 2017 |
Octreotide ameliorates inflammation and apoptosis in acute and kindled murine PTZ paradigms.
Topics: Animals; Anti-Inflammatory Agents; Anticonvulsants; Apoptosis; Caspase 3; Cerebral Cortex; Cytoprote | 2017 |
Efficacy and tolerability of anti-epileptic drugs-an internet study.
Topics: Adult; Anticonvulsants; Carbamazepine; Depression; Epilepsy; Female; Humans; Internet; Lamotrigine; | 2017 |
Epilepsy with myoclonic absences: Electroclinical characteristics in a distinctive pediatric epilepsy phenotype.
Topics: Anticonvulsants; Brain; Child; Child, Preschool; Cohort Studies; Drug Therapy, Combination; Electroe | 2016 |
Cytisine inhibits the protective activity of various classical and novel antiepileptic drugs against 6 Hz-induced psychomotor seizures in mice.
Topics: Alkaloids; Animals; Anticonvulsants; Azocines; Dose-Response Relationship, Drug; Electroshock; Levet | 2017 |
Effects of UGT1A6 and GABRA1 on Standardized Valproic Acid Plasma Concentrations and Treatment Effect in Children With Epilepsy in China.
Topics: Adolescent; Age Factors; Anticonvulsants; Asian People; Child; Child, Preschool; China; Dose-Respons | 2016 |
Adjuvant neuronal nitric oxide synthase inhibition for combined treatment of epilepsy and comorbid depression.
Topics: Animals; Anticonvulsants; Chemotherapy, Adjuvant; Depression; Dose-Response Relationship, Drug; Enzy | 2017 |
Effect of Sodium Valproate on Cognitive Function and Hippocampus of Rats After Convulsive Status Epilepticus.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cognition; Excitatory Postsynaptic Pote | 2016 |
Anti-Epileptic Drug Combination Efficacy in an In Vitro Seizure Model - Phenytoin and Valproate, Lamotrigine and Valproate.
Topics: Animals; Anticonvulsants; Drug Combinations; Drug Interactions; Female; Hippocampus; In Vitro Techni | 2017 |
Late-onset nonlesional nondominant frontal lobe seizures presenting as ictal dyscalculia.
Topics: Age of Onset; Aged; Anticonvulsants; Diagnosis, Differential; Dyscalculia; Electroencephalography; F | 2017 |
Parachlorophenylalanine-induced 5-HT depletion alters behavioral and brain neurotransmitters levels in 6-Hz psychomotor seizure model in mice.
Topics: Animals; Brain; Disease Models, Animal; Electroshock; gamma-Aminobutyric Acid; Glutamine; Male; Mice | 2017 |
Prolonged valproic acid treatment does not reduce the size of latent HIV reservoir.
Topics: Adult; Anticonvulsants; Antiretroviral Therapy, Highly Active; Case-Control Studies; CD4-Positive T- | 2008 |
Factor VII deficiency associated with valproate treatment.
Topics: Anticonvulsants; Child, Preschool; Diagnosis, Differential; Factor VII; Factor VII Deficiency; Follo | 2008 |
A study on epileptic negative myoclonus in atypical benign partial epilepsy of childhood.
Topics: Adrenal Cortex Hormones; Anticonvulsants; Brain; Carbamazepine; Child; Child, Preschool; Clonazepam; | 2009 |
Hippocampal remodelling after MDMA neurotoxicity: a single case study.
Topics: Adolescent; Anticonvulsants; Body Temperature Regulation; Cognition Disorders; Electroencephalograph | 2009 |
Familial hemiplegic migraine with prolonged aura and multimodality imaging: a case report.
Topics: Adrenal Cortex Hormones; Anticonvulsants; Child; Electroencephalography; Female; Humans; Magnetic Re | 2009 |
Dose-finding study with nicotine as a proconvulsant agent in PTZ-induced seizure model in mice.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Dru | 2008 |
DNA topoisomerase I inhibitors ameliorate seizure-like behaviors and paralysis in a Drosophila model of epilepsy.
Topics: Analysis of Variance; Animals; Animals, Genetically Modified; Bromates; Camptothecin; Disease Models | 2008 |
Isobolographic characterization of interactions of retigabine with carbamazepine, lamotrigine, and valproate in the mouse maximal electroshock-induced seizure model.
Topics: Animals; Anticonvulsants; Avoidance Learning; Behavior, Animal; Brain; Carbamates; Carbamazepine; Di | 2009 |
Association of lamotrigine and valproate in refractory epilepsies of children and adolescents.
Topics: Adolescent; Age Distribution; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; E | 2008 |
[Posterior reversible leukoencephalopathy in a patient with postpartum eclampsia].
Topics: Adult; Anticonvulsants; Antihypertensive Agents; Brain; Brain Edema; Cesarean Section; Diazepam; Dru | 2008 |
Early effects of sodium valproate monotherapy on serum paraoxonase/arylesterase activities.
Topics: Antioxidants; Aryldialkylphosphatase; Carboxylic Ester Hydrolases; Case-Control Studies; Child; Chil | 2009 |
[Use of anticonvulsant pregabalin as an add-on therapy in patients with partial epilepsy with polymorphic seizures].
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Epilepsies, Partial; F | 2008 |
A case with Stevens Johnson syndrome triggered by combination of clobazam, lamotrigine, and valproic acid treatment.
Topics: Anticonvulsants; Benzodiazepines; Child, Preschool; Clobazam; Drug Therapy, Combination; Follow-Up S | 2009 |
Valproate-induced hyperammonemic encephalopathy.
Topics: Adolescent; Ammonia; Brain Diseases, Metabolic; Female; Humans; Seizures; Valproic Acid | 2008 |
Effect of concomitant administration of meropenem and valproic acid in an elderly Chinese patient.
Topics: Aged, 80 and over; Anti-Bacterial Agents; Anticonvulsants; Drug Administration Schedule; Drug Intera | 2009 |
Schizencephaly associated with bipolar II disorder.
Topics: Bipolar Disorder; Brain; Citalopram; Depression; Diagnosis, Differential; Dibenzothiazepines; Humans | 2009 |
Interaction of tiagabine with valproate in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis for non-parallel dose-response relationship curves.
Topics: Animals; Anticonvulsants; Brain Chemistry; Convulsants; Dose-Response Relationship, Drug; Drug Inter | 2009 |
Life-threatening organ failure after lamotrigine therapy.
Topics: Anticonvulsants; Child; Contraindications; Drug Therapy, Combination; Exanthema; Female; Fever; Huma | 2009 |
Acquired von Willebrand syndrome as side effect of valproic acid therapy in children is rare.
Topics: Anticonvulsants; Child; Factor VIII; Humans; Seizures; Valproic Acid; von Willebrand Diseases; von W | 2009 |
Anticonvulsant and acute neurotoxic effects of imperatorin, osthole and valproate in the maximal electroshock seizure and chimney tests in mice: a comparative study.
Topics: Angelica archangelica; Animals; Anticonvulsants; Behavior, Animal; Cnidium; Coumarins; Dogs; Dose-Re | 2009 |
Efficacy of anti-epileptic drugs in patients with gliomas and seizures.
Topics: Adult; Anticonvulsants; Brain Neoplasms; Carbamazepine; Drug Therapy, Combination; Female; Follow-Up | 2009 |
N-(anilinomethyl)-p-isopropoxyphenylsuccinimide potentiates the anticonvulsant action of phenobarbital and valproate in the mouse maximal electroshock-induced seizure model.
Topics: Aniline Compounds; Animals; Anticonvulsants; Brain; Carbamazepine; Dose-Response Relationship, Drug; | 2009 |
Serum biotinidase activity in children treated with valproic acid and carbamazepine.
Topics: Alanine Transaminase; Ammonia; Anticonvulsants; Aspartate Aminotransferases; Biotinidase; Carbamazep | 2010 |
Effectiveness of the first antiepileptic drug in the treatment of pediatric epilepsy.
Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Epilepsy; Fructose; Humans; Retrospective S | 2009 |
Posterior reversible encephalopathy syndrome posttransplantation: a case report of possible association with cerebrospinal fluid leak after epidural catheterization.
Topics: Adult; Cerebrospinal Fluid; Creatinine; Encephalitis; Female; Humans; Kidney Transplantation; Living | 2009 |
Synthesis, structural analysis and anticonvulsant activity of a ternary Cu(II) mononuclear complex containing 1,10-phenanthroline and the leading antiepileptic drug valproic acid.
Topics: Animals; Anticonvulsants; Copper; Crystallography, X-Ray; Electron Spin Resonance Spectroscopy; Male | 2009 |
A cocaine body packer case report: clinical and forensic aspects.
Topics: Anticonvulsants; Cocaine; Crime; Digestive System; Epilepsy; Fatal Outcome; Foreign Bodies; Forensic | 2009 |
Isobolographic characterization of the anticonvulsant interaction profiles of levetiracetam in combination with clonazepam, ethosuximide, phenobarbital and valproate in the mouse pentylenetetrazole-induced seizure model.
Topics: Animals; Anticonvulsants; Clonazepam; Convulsants; Disease Models, Animal; Drug Interactions; Drug T | 2009 |
Evaluation of stereoselective anticonvulsant, teratogenic, and pharmacokinetic profile of valnoctylurea (capuride): a chiral stereoisomer of valproic acid urea derivative.
Topics: Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug | 2010 |
Antiepileptic drugs abolish ictal but not interictal epileptiform discharges in vitro.
Topics: 4-Aminopyridine; Action Potentials; Animals; Anticonvulsants; Brain; Carbamazepine; Convulsants; Dis | 2010 |
Predictors and prognosis of status epilepticus treated with intravenous sodium valproate.
Topics: Adolescent; Adult; Anticonvulsants; Data Interpretation, Statistical; Female; Humans; Injections, In | 2009 |
Valproic acid toxicity associated with low dose of aspirin and low total valproic acid levels: a case report.
Topics: Aspirin; Dose-Response Relationship, Drug; Drug Interactions; Drug-Related Side Effects and Adverse | 2009 |
Vigabatrin but not valproate prevents development of age-specific flexion seizures induced by N-methyl-D-aspartate (NMDA) in immature rats.
Topics: Age Factors; Animals; Animals, Newborn; Anticonvulsants; Behavior, Animal; Disease Models, Animal; E | 2010 |
Anticonvulsant profile and teratogenic evaluation of potent new analogues of a valproic acid urea derivative in NMRI mice.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Bone and Bones; Deep Sedation; Differential T | 2009 |
The usefulness of olfactory bulb kindling as a model for evaluation of antiepileptics.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Disease Models, Animal; Electri | 2010 |
Pharmacokinetic interaction between sodium valproate and mycophenolate in renal allograft recipients.
Topics: Adolescent; Adult; Anticonvulsants; Area Under Curve; Azathioprine; Female; Glucocorticoids; Graft R | 2009 |
Post-ictal psychosis in adolescent Niemann-Pick disease type C.
Topics: Adolescent; Age Factors; Anticonvulsants; Cells, Cultured; Cholesterol Esters; Esterification; Fibro | 2010 |
Antiepileptogenic and anticonvulsive actions of levetiracetam in a pentylenetetrazole kindling model.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Dru | 2010 |
Magnesium supplementation enhances the anticonvulsant potential of valproate in pentylenetetrazol-treated rats.
Topics: Animals; Anticonvulsants; Brain; Disease Models, Animal; Drug Synergism; gamma-Aminobutyric Acid; Gl | 2010 |
Levetiracetam in submaximal subcutaneous pentylentetrazol-induced seizures in rats.
Topics: Animals; Anticonvulsants; Convulsants; Dose-Response Relationship, Drug; Electroshock; Epilepsy, Gen | 2010 |
Late-onset nocturnal intractable seizure during sleep: what is the origin?
Topics: Anticonvulsants; Clonazepam; Epilepsy; Follow-Up Studies; Humans; Male; Middle Aged; Polysomnography | 2010 |
Pharmacokinetics and clinical application of intravenous valproate in Thai epileptic children.
Topics: Adolescent; Ammonia; Anticonvulsants; Child; Child, Preschool; Cross-Sectional Studies; Epilepsy; Fe | 2011 |
Angiotensin AT1 receptor antagonists enhance the anticonvulsant action of valproate in the mouse model of maximal electroshock.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Anticonvulsants; Behavior, Animal; Benzimidazoles; | 2010 |
Long-term outcome of 32 children with encephalopathy with status epilepticus during sleep, or ESES syndrome.
Topics: Adolescent; Anticonvulsants; Child; Cognition Disorders; Drug Therapy, Combination; Electroencephalo | 2010 |
Synthesis and anticonvulsant activity of 4-oxo and 4-thioxo-8-bromobenzopyran derivatives.
Topics: Animals; Anticonvulsants; Benzopyrans; Electroshock; Indicators and Reagents; Lethal Dose 50; Male; | 2010 |
Interactions of stiripentol with clobazam and valproate in the mouse maximal electroshock-induced seizure model.
Topics: Analysis of Variance; Animals; Anticonvulsants; Avoidance Learning; Behavior, Animal; Benzodiazepine | 2010 |
[Multiple cerebral cavernomatosis in a 1-year-old child].
Topics: Brain Neoplasms; Female; Hemangioma, Cavernous; Humans; Infant; Magnetic Resonance Imaging; Seizures | 2010 |
An experimental study of the anticonvulsant effect of amlodipine in mice.
Topics: Amlodipine; Animals; Anticonvulsants; Calcium Channel Blockers; Convulsants; Disease Models, Animal; | 2010 |
Anticonvulsant potential of the peroxisome proliferator-activated receptor γ agonist pioglitazone in pentylenetetrazole-induced acute seizures and kindling in mice.
Topics: Animals; Anticonvulsants; Kindling, Neurologic; Male; Mice; Pentylenetetrazole; Pioglitazone; PPAR g | 2010 |
Improvement of pentylenetetrazol-induced learning deficits by valproic acid in the adult zebrafish.
Topics: Animals; Anticonvulsants; Avoidance Learning; Behavior, Animal; Brain; Dose-Response Relationship, D | 2010 |
[Goodpasture's syndrome with neurologic involvement and negative ANCA].
Topics: Acute Kidney Injury; Anti-Glomerular Basement Membrane Disease; Antibodies, Antineutrophil Cytoplasm | 2010 |
[Seizure aggravation by valproate in primary generalized epilepsy].
Topics: Adolescent; Anticonvulsants; Epilepsy, Generalized; Humans; Male; Seizures; Valproic Acid | 2011 |
Decrease in serum valproic acid levels during treatment with ertapenem.
Topics: Aged; Anti-Bacterial Agents; beta-Lactams; Cellulitis; Drug Antagonism; Ertapenem; Female; Humans; M | 2010 |
Retrospective analysis of the effectiveness of first-line antiepileptic drugs for generalized onset and unclassified epileptic seizures in Chinese children.
Topics: Age of Onset; Anticonvulsants; Asian People; Carbamazepine; Child; Child, Preschool; Epilepsy; Femal | 2011 |
Intravenous valproate for seizures in 137 Taiwanese children - valproate naive and non-naive.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Female; Humans; Infant; Injections, Intravenou | 2010 |
Benign infantile focal epilepsy with midline spikes and waves during sleep: a new epileptic syndrome or a variant of benign focal epilepsy?
Topics: Age of Onset; Anticonvulsants; Carbamazepine; Child, Preschool; Drug Therapy, Combination; Electroen | 2010 |
Correlation between EEG abnormalities and symptoms of autism spectrum disorder (ASD).
Topics: Adolescent; Age of Onset; Aging; Anticonvulsants; Asperger Syndrome; Autistic Disorder; Brain Mappin | 2010 |
Effects of three N-(carboxyanilinomethyl) derivatives of p-isopropoxyphenylsuccinimide on the anticonvulsant action of carbamazepine, phenobarbital, phenytoin and valproate in the mouse maximal electroshock-induced seizure model.
Topics: Aniline Compounds; Animals; Anticonvulsants; Behavior, Animal; Brain; Carbamazepine; Disease Models, | 2010 |
Sodium valproate and highly active antiretroviral therapy in HIV positive patients who develop new onset seizures.
Topics: Adult; Antiretroviral Therapy, Highly Active; Child; Drug Therapy, Combination; Female; HIV Infectio | 2011 |
Polymerase γ gene POLG determines the risk of sodium valproate-induced liver toxicity.
Topics: Adolescent; Adult; Amino Acid Substitution; Bipolar Disorder; Child; Child, Preschool; Diffuse Cereb | 2010 |
Predictability of individualized dosage regimens of carbamazepine and valproate mono- and combination therapy.
Topics: Adult; Aged; Anticonvulsants; Bayes Theorem; Carbamazepine; Chronic Disease; Databases, Factual; Dem | 2011 |
Familial hyperinsulinism-hyperammonemia syndrome in a family with seizures: case report.
Topics: Adult; Anticonvulsants; Child, Preschool; Congenital Hyperinsulinism; Family Health; Female; Glutama | 2010 |
Unilateral opercular lesion and eating-induced seizures.
Topics: Anticonvulsants; Brain Neoplasms; Cerebral Cortex; Diagnosis, Differential; Eating; Electroencephalo | 2010 |
Prevention of sodium valproate-induced hepatotoxicity by curcumin, rosiglitazone and N-acetylcysteine in rats.
Topics: Acetylcysteine; Animals; Anticonvulsants; Body Weight; Chemical and Drug Induced Liver Injury; Convu | 2010 |
Synthetic cannabinoid WIN 55,212-2 mesylate enhances the protective action of four classical antiepileptic drugs against maximal electroshock-induced seizures in mice.
Topics: Animals; Anticonvulsants; Avoidance Learning; Benzoxazines; Cannabinoid Receptor Agonists; Carbamaze | 2011 |
Anticonvulsant activity of BmK AS, a sodium channel site 4-specific modulator.
Topics: Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Cells, Cultured; Convulsants; Dise | 2011 |
Paradoxical increase in seizure frequency with valproate in nonketotic hyperglycinemia.
Topics: Anticonvulsants; Brain; Child; Dextromethorphan; Excitatory Amino Acid Antagonists; Female; Humans; | 2012 |
High unbound fraction of valproic acid in a hypoalbuminemic critically ill patient on renal replacement therapy.
Topics: Anticonvulsants; Critical Illness; Female; Humans; Hypoalbuminemia; Middle Aged; Renal Replacement T | 2011 |
Effect of combined treatment of thioperamide with some antiepileptic drugs on methionine-sulfoximine induced convulsions in mice.
Topics: Amines; Animals; Anticonvulsants; Brain; Cyclohexanecarboxylic Acids; Drug Combinations; Gabapentin; | 2010 |
Paliperidone-associated seizure after discontinuation of sodium valproate: a case report.
Topics: Adult; Humans; Isoxazoles; Male; Paliperidone Palmitate; Pyrimidines; Seizures; Valproic Acid | 2011 |
Risk factors for late-onset seizures related to cerebral contusions in adults with a moderate traumatic brain injury.
Topics: Adult; Aged; Aging; Anticonvulsants; Brain; Brain Injuries; Carbamazepine; Electroencephalography; F | 2011 |
Valproate treatment after liver transplant in a patient with Lennox-Gastaut syndrome.
Topics: Anticonvulsants; Chemical and Drug Induced Liver Injury; Electroencephalography; Female; Fructose; H | 2011 |
Serum concentrations of rufinamide in children and adults with epilepsy: the influence of dose, age, and comedication.
Topics: Adolescent; Adult; Age Factors; Anticonvulsants; Body Weight; Child; Child, Preschool; Dose-Response | 2011 |
A case of polyglandular autoimmune syndrome type I with unusual presentation.
Topics: Alcaligenes faecalis; Anti-Bacterial Agents; Anti-Inflammatory Agents; Anticonvulsants; Antifungal A | 2011 |
Reversible dementia and gait disturbance after prolonged use of valproic acid.
Topics: Aged; Anticonvulsants; Cerebral Ventricles; Dementia; Female; Gait Disorders, Neurologic; Hearing Lo | 2011 |
[Staring episodes in children with developmental disorders: epilepsy or behaviour?].
Topics: Attention Deficit Disorder with Hyperactivity; Autistic Disorder; Child; Child Behavior; Diagnosis, | 2011 |
Valproate-induced worsening of seizures: clue to underlying diagnosis.
Topics: Anticonvulsants; Child, Preschool; Female; Humans; Seizures; Valproic Acid | 2011 |
Subacute encephalopathy and seizures in alcoholics (SESA) presenting with non-convulsive status epilepticus.
Topics: Acetamides; Alcohol Withdrawal Seizures; Alcoholism; Anticonvulsants; Brain Diseases; Confusion; Dif | 2011 |
Valproate reduces spontaneous generalized spikes and waves but not photoparoxysmal reactions in patients with idiopathic generalized epilepsies.
Topics: Adolescent; Anticonvulsants; Brain; Child; Electroencephalography; Epilepsy, Generalized; Female; Hu | 2011 |
[Prolonged convulsion after intoxication of alachlor herbicide (Lasso): a case report].
Topics: Acetamides; Anticonvulsants; Clonazepam; Gastric Lavage; Herbicides; Humans; Male; Middle Aged; Mult | 2011 |
Brain delivery of valproic acid via intranasal administration of nanostructured lipid carriers: in vivo pharmacodynamic studies using rat electroshock model.
Topics: Administration, Intranasal; Animals; Anticonvulsants; Blood-Brain Barrier; Brain; Disease Models, An | 2011 |
Valproic acid and warfarin: an underrecognized drug interaction.
Topics: Aged; Anticoagulants; Anticonvulsants; Blood Coagulation Disorders; Drug Interactions; Female; Human | 2011 |
The influence of valproic acid and carbamazepine treatment on serum biotin and zinc levels and on biotinidase activity.
Topics: Adolescent; Anticonvulsants; Biotin; Biotinidase; Carbamazepine; Child; Female; Humans; Male; Seizur | 2011 |
Levetiracetam compared to valproic acid: plasma concentration levels, adverse effects and interactions in aneurysmal subarachnoid hemorrhage.
Topics: Administration, Oral; Aged; Aneurysm, Ruptured; Anti-Bacterial Agents; Anticonvulsants; Biological A | 2011 |
Effects of WIN 55,212-2 mesylate (a synthetic cannabinoid) on the protective action of clonazepam, ethosuximide, phenobarbital and valproate against pentylenetetrazole-induced clonic seizures in mice.
Topics: Animals; Anticonvulsants; Avoidance Learning; Benzoxazines; Brain; Cannabinoid Receptor Agonists; Cl | 2011 |
Rare magnetic resonance imaging findings in medium-chain acyl-coenzyme A dehydrogenase deficiency.
Topics: Acyl-CoA Dehydrogenase; Anticonvulsants; Basal Ganglia; Brain; Brain Ischemia; Carnitine; Cerebral I | 2011 |
Inhibitory effects of valproate on impairment of Y-maze alternation behavior induced by repeated electroconvulsive seizures and c-Fos protein levels in rat brains.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Brain-Derived Neurotrophic Factor; Electroshock; | 2011 |
Valproic acid as the AED of choice for patients with glioblastoma? The jury is out.
Topics: Anticonvulsants; Brain Neoplasms; Glioblastoma; Humans; Seizures; Valproic Acid | 2011 |
Short report: A calcified Taenia solium granuloma associated with recurrent perilesional edema causing refractory seizures: histopathological features.
Topics: Albendazole; Animals; Anthelmintics; Anticonvulsants; Calcinosis; Edema; Granuloma; Humans; Levetira | 2011 |
Design and pharmacological activity of glycinamide and N-methoxy amide derivatives of analogs and constitutional isomers of valproic acid.
Topics: Amides; Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Electroshock; Female; Isomeri | 2011 |
Valproate-induced hyperammonemia and seizures: perioperative concerns.
Topics: Anticonvulsants; Humans; Hyperammonemia; Infant; Magnetic Resonance Imaging; Male; Neurotoxicity Syn | 2011 |
[Concussive convulsions: seizure or no seizure?].
Topics: Adult; Anticonvulsants; Brain; Brain Concussion; Electroencephalography; Epilepsy, Post-Traumatic; E | 2011 |
The interactions of atorvastatin and fluvastatin with carbamazepine, phenytoin and valproate in the mouse maximal electroshock seizure model.
Topics: Animals; Anticonvulsants; Atorvastatin; Brain; Carbamazepine; Disease Models, Animal; Drug Interacti | 2012 |
The anticonvulsant response to valproate in kindled rats is correlated with its effect on neuronal firing in the substantia nigra pars reticulata: a new mechanism of pharmacoresistance.
Topics: Action Potentials; Analysis of Variance; Animals; Anticonvulsants; Disease Models, Animal; Electric | 2011 |
The antiepileptic effect of sodium valproate during different phases of the estrous cycle in PTZ-induced seizures in rats.
Topics: Animals; Anticonvulsants; Estrous Cycle; Female; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; V | 2012 |
Unilateral basal-ganglia involvement likely due to valproate-induced hyperammonemic encephalopathy.
Topics: Anticonvulsants; Basal Ganglia; Brain Diseases; Child, Preschool; Diffusion Magnetic Resonance Imagi | 2012 |
[Acute Intermittent porphyria and valproic acid].
Topics: Anticonvulsants; Female; Humans; Middle Aged; Porphyria, Acute Intermittent; Seizures; Valproic Acid | 2012 |
Stepwise synchronization through the corpus callosum is one cause of myoclonic jerks.
Topics: Anticonvulsants; Cognition Disorders; Corpus Callosum; Cortical Synchronization; Drug Resistance; El | 2012 |
Synthesis and anticonvulsant evaluation of some new 2,3,8-trisubstituted-4(3H)-quinazoline derivatives.
Topics: Animals; Anticonvulsants; Chemistry, Pharmaceutical; Drug Design; Humans; Male; Methaqualone; Mice; | 2012 |
A new derivative of valproic acid amide possesses a broad-spectrum antiseizure profile and unique activity against status epilepticus and organophosphate neuronal damage.
Topics: Amides; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Female; | 2012 |
Focal nonconvulsive seizures during detoxification for benzodiazepine abuse.
Topics: Adult; Anticonvulsants; Benzodiazepines; Female; Flumazenil; GABA Modulators; Humans; Infusions, Int | 2012 |
Analysis of acylcarnitine levels by tandem mass spectrometry in epileptic children receiving valproate and oxcarbazepine.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Carnitine; Child; Child, Preschool; Chromatography, High | 2011 |
Interaction of hydroalcoholic extract of Acorus calamus Linn. with sodium valproate and carbamazepine.
Topics: Acorus; Animals; Anticonvulsants; Carbamazepine; Convulsants; Dose-Response Relationship, Drug; Drug | 2012 |
Peri-ictal prolonged atrial fibrillation after generalized seizures: description of a case and etiopathological considerations.
Topics: Anticonvulsants; Atrial Fibrillation; Electrocardiography; Electroencephalography; Follow-Up Studies | 2012 |
Repetitive transcranial magnetic stimulation safely administered after seizure.
Topics: Adult; Anticonvulsants; Depressive Disorder, Major; Humans; Male; Prefrontal Cortex; Psychiatric Sta | 2012 |
Kynurenic acid: a new effector of valproate action?
Topics: Animals; Anticonvulsants; Hippocampus; Kindling, Neurologic; Kynurenic Acid; Male; Neurons; Pentylen | 2011 |
Combined diazepam and HDAC inhibitor treatment protects against seizures and neuronal damage caused by soman exposure.
Topics: Animals; Anticonvulsants; Brain; Brain Mapping; Brain Waves; Chemical Warfare Agents; Cytoprotection | 2012 |
Variability of carbamazepine and valproate concentrations in elderly nursing home residents.
Topics: Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Data Interpretation, Statistical; Databases | 2012 |
Anticonvulsant activity of bisabolene sesquiterpenoids of Curcuma longa in zebrafish and mouse seizure models.
Topics: Analysis of Variance; Animals; Animals, Genetically Modified; Anticonvulsants; Chromatography, High | 2012 |
Pilomotor seizure: when paroxysmal gooseflesh heralds brain tumor.
Topics: Aged; Amygdala; Anticonvulsants; Astrocytoma; Brain Neoplasms; Electroencephalography; Hippocampus; | 2012 |
Seizure management at Auckland City Hospital Emergency Department between July and December 2009: time for a change?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Disease Management; Emer | 2012 |
Influence of calcium channel blockers on anticonvulsant and antinociceptive activities of valproic acid in pentylenetetrazole-kindled mice.
Topics: Analgesics; Animals; Anticonvulsants; Calcium Channel Blockers; Disease Models, Animal; Drug Synergi | 2012 |
Anticonvulsant-induced rickets and nephrocalcinosis.
Topics: Anticonvulsants; Child; Diagnosis, Differential; Fanconi Syndrome; Female; Fructose; Humans; Nephroc | 2012 |
Combination of valproate and paroxetine in mice exposed to picrotoxin.
Topics: Animals; Anticonvulsants; Brain Chemistry; Drug Combinations; gamma-Aminobutyric Acid; Mice; Nucleus | 2012 |
Prevalence of seizures in children infected with human immunodeficiency virus.
Topics: Anticonvulsants; Carbamazepine; Child; Child, Preschool; Female; HIV Infections; Humans; Male; Pheno | 2013 |
Closed-loop neural stimulation for pentylenetetrazole-induced seizures in zebrafish.
Topics: Animals; Anticonvulsants; Brain Stem; Convulsants; Disease Models, Animal; Electric Stimulation Ther | 2013 |
Reduced valproic acid serum concentrations due to drug interactions with carbapenem antibiotics: overview of 6 cases.
Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Carbapenems; Drug Interactions; Drug Monitoring; Fem | 2012 |
[Clinical and electroencephalographic characteristics of Jeavons syndrome].
Topics: Adolescent; Age of Onset; Anticonvulsants; Child; Child, Preschool; Electroencephalography; Electrom | 2012 |
Randomised controlled monotherapy trials: which comparators to use?
Topics: Anticonvulsants; Carbamazepine; Epilepsies, Partial; Epilepsy; Humans; Seizures; Valproic Acid | 2012 |
Epileptiform activity and cognitive deficits in SNAP-25(+/-) mice are normalized by antiepileptic drugs.
Topics: Animals; Anticonvulsants; Association Learning; Brain; Carbamazepine; Cognition Disorders; Epilepsy; | 2014 |
[Pharmacological interaction between meropenem and valproic acid: a report of two cases].
Topics: Anticonvulsants; beta-Lactamase Inhibitors; Child, Preschool; Drug Interactions; Epilepsy; Fatal Out | 2012 |
Effects of Korean red ginseng extracts on neural tube defects and impairment of social interaction induced by prenatal exposure to valproic acid.
Topics: Animals; Behavior, Animal; Child; Child Development Disorders, Pervasive; Disease Models, Animal; Fe | 2013 |
Seizure control by ketogenic diet-associated medium chain fatty acids.
Topics: Animals; Anticonvulsants; Caprylates; Cell Line; Chemical and Drug Induced Liver Injury; Convulsants | 2013 |
Antiepileptic drugs prevent changes in adenosine deamination during acute seizure episodes in adult zebrafish.
Topics: Adenine Nucleotides; Adenosine; Adenosine Deaminase; Amines; Animals; Anticonvulsants; Brain; Cycloh | 2013 |
Epilepsy in Mowat-Wilson syndrome: delineation of the electroclinical phenotype.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; DNA Mutational Analysis; Electroencephalograph | 2013 |
Interaction of the neurosteroid alphaxalone with conventional antiepileptic drugs in different types of experimental seizures.
Topics: Aminophylline; Amygdala; Anesthetics; Animals; Anticonvulsants; Avoidance Learning; Convulsants; Dru | 2002 |
Combination of carbamazepine and valproate in different dose proportions in maximal electroshock seizure model in mice.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; D | 2002 |
Effect of seizures and antiepileptic drugs on prolactin secretions.
Topics: Adolescent; Adult; Anticonvulsants; Drug Therapy, Combination; Female; Humans; Male; Phenytoin; Prol | 2002 |
Synergistic interaction between valproate and lamotrigine against seizures induced by 4-aminopyridine and pentylenetetrazole in mice.
Topics: Animals; Brain; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Lamotri | 2002 |
Anticonvulsant valproate reduces seizure-susceptibility in mutant Drosophila.
Topics: Action Potentials; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Dru | 2002 |
Successful treatment of Ohtahara syndrome with chloral hydrate.
Topics: Anticonvulsants; Chloral Hydrate; Drug Therapy, Combination; Electroencephalography; Female; Humans; | 2002 |
Visual hallucinations associated with zonisamide.
Topics: Adolescent; Adult; Anticonvulsants; Child; Female; Hallucinations; Humans; Landau-Kleffner Syndrome; | 2003 |
Characterization of the anticonvulsant profile and enantioselective pharmacokinetics of the chiral valproylamide propylisopropyl acetamide in rodents.
Topics: Allylisopropylacetamide; Amides; Animals; Anticonvulsants; Cells, Cultured; Cerebral Cortex; Dose-Re | 2003 |
Effects of valproate, phenytoin, and zonisamide on clonic and tonic seizures induced by acute and repeated exposure of mice to flurothyl.
Topics: Animals; Anticonvulsants; Brain Stem; Convulsants; Epilepsy, Tonic-Clonic; Flurothyl; Isoxazoles; Ki | 2003 |
Safety and efficacy of intravenous valproate in pediatric status epilepticus and acute repetitive seizures.
Topics: Acute Disease; Adolescent; Anticonvulsants; Child; Child, Preschool; Dose-Response Relationship, Dru | 2003 |
Is the interaction between felbamate and valproate against seizures induced by 4-aminopyridine and pentylenetetrazole in mice beneficial?
Topics: 4-Aminopyridine; Analysis of Variance; Animals; Brain; Chromatography, Liquid; Disease Models, Anima | 2003 |
Anticonvulsant activity, teratogenicity and pharmacokinetics of novel valproyltaurinamide derivatives in mice.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Embryonic | 2003 |
Septo-optic dysplasia plus.
Topics: Adult; Anticonvulsants; Cerebral Cortex; Humans; Magnetic Resonance Imaging; Male; Radiography; Seiz | 2003 |
Design, synthesis and anticonvulsive activities of potential prodrugs linked by two-carbon chain.
Topics: Animals; Anticonvulsants; Carbon; Convulsants; Dimerization; Drug Design; Electroshock; gamma-Aminob | 2003 |
Hypoalbuminemia with valproic acid administration.
Topics: Adult; Anticonvulsants; Child; Child, Preschool; Female; Humans; Hypoalbuminemia; Male; Seizures; Se | 2003 |
Compliance and satisfaction with switching from an immediate-release to sustained-release formulation of valproate in people with epilepsy.
Topics: Adaptation, Psychological; Adolescent; Adult; Age of Onset; Aged; Anticonvulsants; Delayed-Action Pr | 2003 |
Effect of valproic acid on levels of GABA and glutamic acid in pentylenetetrazole-damaged rat brain.
Topics: Animals; Anticonvulsants; Body Weight; Brain Chemistry; Convulsants; gamma-Aminobutyric Acid; Glutam | 2003 |
Appropriateness of serum level determinations of antiepileptic drugs.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants; Carbamazepine; Drug Monitoring; Female; | 2003 |
Valproic acid-hydrophilic cyclodextrin complexes and valproic acid-solid dispersions: evaluation of their potential pharmaceutical use.
Topics: Algorithms; Animals; Anticonvulsants; Calorimetry, Differential Scanning; Chromatography, High Press | 2004 |
Rett syndrome: a case presenting with atypical seizures. Neurophysiological and clinical aspects.
Topics: Anticonvulsants; Child; Electroencephalography; Female; Humans; Rett Syndrome; Seizures; Valproic Ac | 2004 |
Hypersensitivity to topiramate sprinkle capsules does not preclude the use of topiramate tablets.
Topics: Administration, Oral; Adolescent; Anticonvulsants; Benzodiazepines; Capsules; Carbamazepine; Clobaza | 2004 |
Metabolism of a new antiepileptic drug, N-methyl-tetramethylcyclopropanecarboxamide, and anticonvulsant activity of its metabolites.
Topics: Amides; Animals; Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Behavior, Animal; Biotransformation | 2004 |
Assessment of seizure aggravation.
Topics: Anticonvulsants; Clinical Trials as Topic; Humans; Outcome Assessment, Health Care; Research Design; | 2004 |
Design, synthesis and anticonvulsive activity of analogs of gamma-vinyl GABA.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Design; Isonipecotic Acids; Male; Mice; Nipec | 2004 |
Dosing differences between valproic acid concentrate and divalproex sodium: a case report.
Topics: Administration, Oral; Adult; Antipsychotic Agents; Biological Availability; Clozapine; Delayed-Actio | 2004 |
Neuroblastoma, maternal valproic acid use, in-vitro fertilization and family history of mosaic chromosome 22: coincidence or causal relationship?
Topics: Adult; Anticonvulsants; Child; Chromosomes, Human, Pair 22; Female; Fertilization in Vitro; Humans; | 2004 |
Casebook: epileptic seizures and turns.
Topics: Adolescent; Adult; Anticonvulsants; Contraindications; Diagnosis, Differential; Epilepsy; Female; Hu | 2004 |
Lamotrigine-induced seizure aggravation and negative myoclonus in idiopathic rolandic epilepsy.
Topics: Anticonvulsants; Child; Drug Therapy, Combination; Electroencephalography; Electromyography; Epileps | 2004 |
Isobolographic and subthreshold analysis of interactions among felbamate and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice.
Topics: Animals; Anticonvulsants; Behavior, Animal; Clonazepam; Disease Models, Animal; Drug Interactions; D | 2004 |
Ethosuximide and valproate display high efficacy against lindane-induced seizures in mice.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Co | 2004 |
Aminoglutethimide but not spironolactone enhances the anticonvulsant effect of some antiepileptics against amygdala-kindled seizures in rats.
Topics: Adrenergic Agents; Aminoglutethimide; Amygdala; Animals; Anticonvulsants; Clonazepam; Disease Models | 2005 |
Interactions between riluzole and conventional antiepileptic drugs -- a comparison of results obtained in the subthreshold method and isobolographic analysis.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Drug Interactions; Electroshock; Ma | 2004 |
Efficacy and tolerability of the new antiepileptic drugs I: treatment of new onset epilepsy: report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epileps
Topics: Anticonvulsants; Clinical Trials as Topic; Epilepsy; Fructose; Humans; Seizures; Topiramate; Valproi | 2005 |
Evaluation of the effects of lamotrigine, valproate and carbamazepine in a rodent model of mania.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Bipolar Disorder; Carbamazepine; Central Nervous Syst | 2005 |
Investigating heterogeneity in an individual patient data meta-analysis of time to event outcomes.
Topics: Anticonvulsants; Carbamazepine; Computer Simulation; Epilepsy; Genetic Heterogeneity; Humans; Meta-A | 2005 |
Acute seizures due to a probable interaction between valproic acid and meropenem.
Topics: Acute Disease; Adult; Anti-Bacterial Agents; Anticonvulsants; Drug Interactions; Epilepsy; Female; H | 2005 |
Two cases of valproate-induced hyperammonemic encephalopathy without hepatic failure.
Topics: Ammonia; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Female; Fructose; Huma | 2004 |
Valproic acid, but not lamotrigine, suppresses seizure-induced c-fos and c-Jun mRNA expression.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Flurothyl; Gene Expression Regulation; In Situ Hy | 2005 |
Antiepileptogenic and antioxidant effects of Nigella sativa oil against pentylenetetrazol-induced kindling in mice.
Topics: Adenosine Deaminase; Analysis of Variance; Animals; Anticonvulsants; Antioxidants; Dose-Response Rel | 2005 |
High vulnerability to acute dystonic reactions: a case of antipsychotic exposure and uncontrolled seizure activity.
Topics: Anticonvulsants; Antipsychotic Agents; Chronic Disease; Cytochrome P-450 CYP2D6; Dibenzothiazepines; | 2005 |
Reduced anticonvulsant efficacy of valproic acid in dopamine beta-hydroxylase knockout mice.
Topics: Adrenergic Uptake Inhibitors; Analysis of Variance; Animals; Anticonvulsants; Disease Models, Animal | 2005 |
Cardiac syncope from occult transposition masquerading as convulsive epilepsy.
Topics: Anticonvulsants; Child, Preschool; Diagnosis, Differential; Heart Block; Humans; Male; Seizures; Syn | 2005 |
Hemispheric integrative therapy in Landau-Kleffner syndrome: applications for rehabilitation sciences.
Topics: Adolescent; Anticonvulsants; Brain; Central Nervous System Stimulants; Electroencephalography; Femal | 2005 |
Hepatocellular carcinoma and nonalcoholic steatohepatitis developing during long-term administration of valproic acid.
Topics: Anticonvulsants; Carcinoma, Hepatocellular; Fatty Liver; Hepatitis; Humans; Liver Neoplasms; Male; M | 2005 |
Pharmacodynamic and/or pharmacokinetic characteristics of interactions between loreclezole and four conventional antiepileptic drugs in pentylenetetrazole-induced seizures in mice: an isobolographic analysis.
Topics: Animals; Anticonvulsants; Clonazepam; Dose-Response Relationship, Drug; Drug Interactions; Drug Ther | 2005 |
Valproic acid reduces enhanced vesicular glutamate transporter immunoreactivities in the dentate gyrus of the seizure prone gerbil.
Topics: Action Potentials; Animals; Anticonvulsants; Blotting, Western; Cell Count; Dentate Gyrus; Dose-Resp | 2005 |
Pharmacokinetic interaction between valproic acid and meropenem.
Topics: Adult; Aged; Anticonvulsants; Drug Interactions; Humans; Male; Meropenem; Seizures; Sepsis; Thienamy | 2005 |
An experimental evaluation of anticonvulsant activity of Vitex-negundo.
Topics: Animals; Anticonvulsants; Drug Combinations; Drug Evaluation, Preclinical; Drug Interactions; Electr | 2005 |
Prolonged postictal stupor: nonconvulsive status epilepticus, medication effect, or postictal state?
Topics: Adult; Anticonvulsants; Benzodiazepines; Coma; Diagnosis, Differential; Electroencephalography; Epil | 2005 |
Levetiracetam for mood stabilization and maintenance of seizure control following multiple treatment failures.
Topics: Anticonvulsants; Carbamazepine; Drug Therapy, Combination; Female; Fructose; Humans; Levetiracetam; | 2005 |
Use of phenytoin and other anticonvulsant prophylaxis in patients with aneurysmal subarachnoid hemorrhage.
Topics: Cognition Disorders; Drug Interactions; Humans; Intracranial Aneurysm; Nimodipine; Phenytoin; Seizur | 2005 |
The use of lamotrigine and other antiepileptic drugs in paediatric patients at a Malaysian hospital.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Child; Child, Preschool; Cost-Benefit Analysis; D | 2005 |
Clonidine-induced gynecomastia and hyperprolactinemia in a 6-year-old child.
Topics: Age Factors; Anticonvulsants; Attention Deficit Disorder with Hyperactivity; Child; Clonidine; Comor | 2005 |
2-phosphonomethyl-pentanedioic acid (glutamate carboxypeptidase II inhibitor) increases threshold for electroconvulsions and enhances the antiseizure action of valproate against maximal electroshock-induced seizures in mice.
Topics: Analysis of Variance; Animals; Anticonvulsants; Brain; Carbamazepine; Dose-Response Relationship, Dr | 2006 |
Fatal seizures due to potential herb-drug interactions with Ginkgo biloba.
Topics: Anticonvulsants; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; E | 2005 |
Neuropsychiatric profiles of patients with juvenile myoclonic epilepsy treated with valproate or topiramate.
Topics: Adolescent; Anticonvulsants; Anxiety Disorders; Cross-Sectional Studies; Depressive Disorder; Female | 2006 |
Absence of convulsive liability of doripenem, a new carbapenem antibiotic, in comparison with beta-lactam antibiotics.
Topics: Alanine; Animals; Anti-Bacterial Agents; Anticonvulsants; Carbapenems; Convulsants; Dogs; Doripenem; | 2006 |
EEG and seizure exacerbation induced by carbamazepine in Panayiotopoulos syndrome.
Topics: Anticonvulsants; Carbamazepine; Child, Preschool; Electroencephalography; Epilepsies, Partial; Human | 2006 |
Effects of drugs acting on the GABA-benzodiazepine receptor complex on flurothyl-induced seizures in Mongolian gerbils.
Topics: Amino Acids; Animals; Anticonvulsants; Brain; Convulsants; Diazepam; Ethanol; Flumazenil; Flurothyl; | 2006 |
Facilitation action of N-acetylcysteine on the anticonvulsant effect of sodium valproate in mice.
Topics: Acetylcysteine; Animals; Anticonvulsants; Cerebral Cortex; Drug Synergism; Electroshock; Free Radica | 2006 |
Modulation of pentylenetetrazole-induced seizures and oxidative stress parameters by sodium valproate in the absence and presence of N-acetylcysteine.
Topics: Acetylcysteine; Alanine Transaminase; Animals; Anticonvulsants; Antioxidants; Aspartate Aminotransfe | 2006 |
Anticonvulsant treatment for psychiatric and seizure indications among youths.
Topics: Adolescent; Age Factors; Ambulatory Care; Anticonvulsants; Child; Child, Preschool; Community Mental | 2006 |
Total phenytoin concentrations do not accurately predict free phenytoin concentrations in critically ill children.
Topics: Adolescent; Adult; Anti-Bacterial Agents; Anticonvulsants; Blood Chemical Analysis; Cefazolin; Child | 2006 |
Preclinical evaluation of 2,2,3,3-tetramethylcyclopropanecarbonyl-urea, a novel, second generation to valproic acid, antiepileptic drug.
Topics: Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Body Weight; Cells, Cultured; Cere | 2006 |
Arachidonyl-2'-chloroethylamide, a highly selective cannabinoid CB1 receptor agonist, enhances the anticonvulsant action of valproate in the mouse maximal electroshock-induced seizure model.
Topics: Amidohydrolases; Animals; Anticonvulsants; Arachidonic Acids; Avoidance Learning; Brain; Disease Mod | 2006 |
Pertussis vaccine and infantile spasms.
Topics: Adrenocorticotropic Hormone; Anti-Inflammatory Agents; Anticonvulsants; Diphtheria-Tetanus-Pertussis | 2007 |
Anticonvulsant activity, neural tube defect induction, mutagenicity and pharmacokinetics of a new potent antiepileptic drug, N-methoxy-2,2,3,3-tetramethylcyclopropane carboxamide.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Cyclopropanes; Female; Male; Mice; Mutagenesi | 2007 |
Valproate induced isolated neutropenia.
Topics: Anticonvulsants; Child, Preschool; Female; Humans; Neutropenia; Seizures; Valproic Acid | 2006 |
Hepatotoxicity and valproate therapy.
Topics: Anticonvulsants; Chemical and Drug Induced Liver Injury; Female; Humans; Middle Aged; Seizures; Trea | 2006 |
Autonomic headache with autonomic seizures: a case report.
Topics: Anticonvulsants; Autonomic Nervous System; Diagnosis, Differential; Electroencephalography; Epilepsy | 2006 |
Characterization of the anticonvulsant, behavioral and pharmacokinetic interaction profiles of stiripentol in combination with clonazepam, ethosuximide, phenobarbital, and valproate using isobolographic analysis.
Topics: Animals; Anticonvulsants; Brain Chemistry; Clonazepam; Dioxolanes; Disease Models, Animal; Drug Inte | 2006 |
[Ca2+/calmodulin-dependent protein kinase II--a target for sodium valproate?].
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Calcium-Calmodulin-Dependent Protein Kinase Type 2; | 2006 |
Clinical utility of a continuous intravenous infusion of valproic acid in pediatric patients.
Topics: Administration, Oral; Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combinatio | 2007 |
Reversible cognitive and neurological symptoms during valproic acid therapy.
Topics: Aged, 80 and over; Anticonvulsants; Ataxia; Cognition Disorders; Humans; Male; Seizures; Valproic Ac | 2007 |
Fetal exposure to GABA-acting antiepileptic drugs generates hippocampal and cortical dysplasias.
Topics: Abnormalities, Drug-Induced; Animals; Anticonvulsants; Carbamazepine; Cerebral Cortex; Female; Fetus | 2007 |
Diagnosis of Parkinsonism in older patients receiving sodium valproate.
Topics: Aged; Depression; Female; Humans; Parkinsonian Disorders; Seizures; Valproic Acid | 2007 |
Thalidomide inhibits pentylenetetrazole-induced seizures.
Topics: Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Disease Models, Animal; Dose-Respo | 2007 |
Chronically administered fluoxetine enhances the anticonvulsant activity of conventional antiepileptic drugs in the mouse maximal electroshock model.
Topics: Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Drug Interactions; Drug Synergis | 2007 |
Interactions between two enantiomers of losigamone and conventional antiepileptic drugs in the mouse maximal electroshock model--an isobolographic analysis.
Topics: Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Drug Interactions; Electroshock; | 2007 |
Anti-glutamatergic effect of riluzole: comparison with valproic acid.
Topics: Animals; Anticonvulsants; Dentate Gyrus; Disease Models, Animal; Epilepsy, Absence; Excitatory Posts | 2007 |
Guidelines for the management of severe traumatic brain injury. XIII. Antiseizure prophylaxis.
Topics: Anticonvulsants; Brain Injuries; Humans; Phenytoin; Seizures; Time Factors; Valproic Acid | 2007 |
Temporal lobe epilepsy is a disease of faulty neuronal resonators rather than oscillators, and all seizures are provoked, usually by stress.
Topics: Anticonvulsants; Epilepsy; Epilepsy, Temporal Lobe; Ethosuximide; Hippocampus; Humans; Models, Neuro | 2007 |
Hemifacial seizures and cerebellar tumor: a rare co-existence.
Topics: Anticonvulsants; Benzodiazepines; Cerebellar Neoplasms; Child, Preschool; Clobazam; Comorbidity; Gan | 2007 |
Epigenetic modulation of seizure-induced neurogenesis and cognitive decline.
Topics: Action Potentials; Animals; Cognition Disorders; Epigenesis, Genetic; Female; Hippocampus; Neurons; | 2007 |
Isobolographic analysis of interactions between remacemide and conventional antiepileptic drugs in the mouse model of maximal electroshock.
Topics: Acetamides; Algorithms; Animals; Anticonvulsants; Avoidance Learning; Brain; Carbamazepine; Disease | 2007 |
Cholecalciferol enhances the anticonvulsant effect of conventional antiepileptic drugs in the mouse model of maximal electroshock.
Topics: Animals; Anticonvulsants; Avoidance Learning; Carbamazepine; Cholecalciferol; Disease Models, Animal | 2007 |
Acute and chronic treatment with mianserin differentially affects the anticonvulsant activity of conventional antiepileptic drugs in the mouse maximal electroshock model.
Topics: Analysis of Variance; Animals; Anticonvulsants; Antidepressive Agents, Second-Generation; Brain; Car | 2007 |
Acute seizures in a patient receiving divalproex sodium after starting ertapenem therapy.
Topics: Acute Disease; Adult; Anti-Bacterial Agents; Anticonvulsants; beta-Lactams; Dose-Response Relationsh | 2007 |
Furosemide potentiates the anticonvulsant action of valproate in the mouse maximal electroshock seizure model.
Topics: Analysis of Variance; Animals; Anticonvulsants; Brain; Disease Models, Animal; Dose-Response Relatio | 2007 |
Old versus new antiepileptic drugs: the SANAD study.
Topics: Adolescent; Anticonvulsants; Diagnostic Errors; Female; Humans; Kearns-Sayre Syndrome; Liver Failure | 2007 |
Prenatal diagnosis of cerebral lesions in Tuberous sclerosis complex (TSC). Case report and review of the literature.
Topics: Adult; Anticonvulsants; Brain; Female; Genetic Counseling; Heart Neoplasms; Humans; Infant, Newborn; | 2008 |
[Behçet's disease in treatment with cyclosporine and seizures: diagnostic dilemma].
Topics: Adrenal Cortex Hormones; Adult; Anticonvulsants; Behcet Syndrome; Cyclosporins; Electroretinography; | 2007 |
Hyperactivity and inattention--a successful response to table coffee.
Topics: Attention Deficit Disorder with Hyperactivity; Caffeine; Central Nervous System Stimulants; Child, P | 2007 |
Seizure-freedom with combination therapy in localization-related epilepsy.
Topics: Adult; Anticonvulsants; Brain; Carbamazepine; Drug Therapy, Combination; Female; Frontal Lobe; Fruct | 2008 |
Fructose-1,6-bisphosphate has anticonvulsant activity in models of acute seizures in adult rats.
Topics: Acute Disease; Allylamine; Analysis of Variance; Animals; Anticonvulsants; Behavior, Animal; Deoxygl | 2007 |
'Armoured brain'. A case report of a calcified chronic subdural haematoma.
Topics: Adult; Brain; Calcinosis; Female; Hematoma, Subdural, Chronic; Humans; Infant; Seizures; Valproic Ac | 2008 |
The anticonvulsant profile of rufinamide (CGP 33101) in rodent seizure models.
Topics: Administration, Oral; Animals; Anticonvulsants; Disease Models, Animal; Injections, Intraperitoneal; | 2008 |
Agmatine enhances the anticonvulsant action of phenobarbital and valproate in the mouse maximal electroshock seizure model.
Topics: Agmatine; Animals; Anticonvulsants; Avoidance Learning; Drug Interactions; Drug Synergism; Electrosh | 2008 |
Acute effects of N-(2-propylpentanoyl)urea on hippocampal amino acid neurotransmitters in pilocarpine-induced seizure in rats.
Topics: Amino Acids; Animals; Anticonvulsants; Hippocampus; Male; Microdialysis; Muscarinic Agonists; Neurot | 2008 |
Hepatic encephalopathy precipitated by sodium valproate therapy.
Topics: Aged; Anticonvulsants; Biopsy; Diagnosis, Differential; Electroencephalography; Female; Follow-Up St | 2008 |
[The use of generic valparin xr in the treatment of epilepsy.].
Topics: Anticonvulsants; Drug Therapy, Combination; Epilepsy; Humans; Seizures; Treatment Outcome; Valproic | 2007 |
Drug-induced changes in GABA content of nerve endings in 11 rat brain regions. Correlation to pharmacological effects.
Topics: Acetates; Aminooxyacetic Acid; Animals; Brain; Dose-Response Relationship, Drug; gamma-Aminobutyric | 1984 |
Protective effects of diazepam and valproate on beta-vinyllactic acid-induced seizures.
Topics: Animals; Brain; Convulsants; Diazepam; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Gl | 1984 |
Effects of seizures and antiepileptic drugs on benzodiazepine receptors in rat brain.
Topics: Acoustic Stimulation; Aminooxyacetic Acid; Animals; Anticonvulsants; Brain; Cerebral Cortex; Flunitr | 1984 |
[Anticonvulsant action of di-N-propylacetate combined with benzodiazepines, phenobarbital and phenytoin].
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Diazepam; Drug Th | 1981 |
Mechanisms of action of antiepileptic drugs.
Topics: Acetazolamide; Animals; Anti-Anxiety Agents; Anticonvulsants; Barbiturates; Benzodiazepines; Carbama | 1982 |
Heterozygous alpha 1-antitrypsin deficiency and valproate hepatotoxicity.
Topics: alpha 1-Antitrypsin Deficiency; Heterozygote; Humans; Infant; Infant, Newborn; Liver; Male; Seizures | 1984 |
EEG and anticonvulsant effects of dipropylacetic acid and dipropylacetamide in the baboon Papio papio.
Topics: Animals; Cerebral Cortex; Dose-Response Relationship, Drug; Electroencephalography; Female; Male; Pa | 1980 |
Recent advances in anticonvulsant management of childhood seizure disorders.
Topics: Anticonvulsants; Carbamazepine; Child; Child Behavior Disorders; Child, Preschool; Clonazepam; Human | 1984 |
Anticonvulsants specific for petit mal antagonize epileptogenic effect of leucine enkephalin.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Endorphins; Enkephalins; Epilepsy, Absence; Ethosu | 1980 |
Drugs that increase gamma-aminobutyric acid transmission protect against the high pressure neurological syndrome.
Topics: Anesthetics; Animals; Bicuculline; Body Temperature; Flurazepam; gamma-Aminobutyric Acid; Male; Mice | 1982 |
The role of different types of adrenergic receptors in pentylenetetrazol-induced seizures and the effect of di-n-propylacetate in the rat.
Topics: Animals; Hydroxydopamines; Male; Oxidopamine; Pentylenetetrazole; Piperoxan; Rats; Receptors, Adrene | 1983 |
DMCM: a potent convulsive benzodiazepine receptor ligand.
Topics: Animals; Carbolines; Convulsants; Diazepam; Drug Interactions; Female; Indoles; Lorazepam; Male; Mic | 1983 |
Pharmacokinetics of valproic acid in children: I. Multiple antiepileptic drug therapy.
Topics: Adolescent; Anticonvulsants; Child; Child, Preschool; Drug Therapy, Combination; Female; Half-Life; | 1983 |
Acute anticonvulsant activity of structural analogues of valproic acid and changes in brain GABA and aspartate content.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Aspartic Acid; Brain; Dose-Response Relationship, Dr | 1983 |
Gastrointestinal tolerance of divalproex sodium.
Topics: Adolescent; Adult; Child; Child, Preschool; Gastrointestinal Diseases; Humans; Middle Aged; Seizures | 1983 |
Studies on the role of serotonin in different regions of the rat central nervous system on pentylenetetrazol-induced seizures and the effect of di-n-propylacetate.
Topics: 5,7-Dihydroxytryptamine; Animals; Anticonvulsants; Brain; Male; Metergoline; Methysergide; Neurons; | 1983 |
High anticonvulsant potency of gamma-aminobutyric acid (GABA)mimetic drugs in gerbils with genetically determined epilepsy.
Topics: Alkynes; Aminocaproates; Aminooxyacetic Acid; Animals; Anticonvulsants; Diazepam; Disease Models, An | 1983 |
Value of Mongolian gerbils in antiepileptic drug evaluation.
Topics: Animals; Anticonvulsants; Disease Models, Animal; Drug Evaluation; Epilepsy; Gerbillinae; Seizures; | 1983 |
The effects of analogues of valproic acid on seizures induced by pentylenetetrazol and GABA content in brain of mice.
Topics: Animals; Anticonvulsants; Brain Chemistry; gamma-Aminobutyric Acid; Male; Mice; Mice, Inbred Strains | 1983 |
Febrile convulsions.
Topics: Anticonvulsants; Child, Preschool; Diazepam; Female; Fever; Humans; Infant; Male; Phenobarbital; Rec | 1983 |
Anticonvulsant potency of common antiepileptic drugs in the gerbil.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Ethosuximide; Female; Gerbillinae; Male; Phenobar | 1983 |
[Serum levels of free valproic acid].
Topics: Anticonvulsants; Drug Therapy, Combination; Humans; Immunoenzyme Techniques; Seizures; Ultrafiltrati | 1984 |
Relationship between drug-induced increases of GABA levels in discrete brain areas and different pharmacological effects in rats.
Topics: Aminooxyacetic Acid; Analgesics; Animals; Body Temperature; Brain Chemistry; Female; gamma-Aminobuty | 1984 |
Comparative evaluation of anticonvulsant and toxic potencies of valproic acid and 2-en-valproic acid in different animal models of epilepsy.
Topics: Animals; Anticonvulsants; Electroshock; Epilepsy; Fatty Acids, Monounsaturated; Fatty Acids, Unsatur | 1984 |
Membrane-disordering potency and anticonvulsant action of valproic acid and other short-chain fatty acids.
Topics: Animals; Anticonvulsants; Brain; Cell Membrane; Ethanol; Fatty Acids; Kinetics; Male; Membrane Fluid | 1984 |
Case report: pancreatic pseudocyst associated with valproic acid therapy.
Topics: Adult; Humans; Male; Pancreatic Cyst; Pancreatic Pseudocyst; Seizures; Valproic Acid | 1984 |
Nonsedative regimens in the treatment of epilepsy.
Topics: Carbamazepine; Epilepsy; Ethosuximide; Humans; Phenytoin; Seizures; Valproic Acid | 1983 |
Effects of SKF525A, phenobarbital, fasting, and carnitine on the anticonvulsant activity and neurotoxicity of valproate in mice.
Topics: Animals; Carnitine; Fasting; Male; Mice; Mice, Inbred Strains; Nervous System; Phenobarbital; Proadi | 1984 |
Pharmacologic therapy of seizures in the elderly.
Topics: Aged; Anticonvulsants; Carbamazepine; Humans; Phenobarbital; Phenytoin; Primidone; Seizures; Status | 1984 |
Lead-induced convulsions in young infants--a case history and the role of GABA and sodium valproate in the pathogenesis and treatment.
Topics: Chemical Phenomena; Chemistry; Citric Acid Cycle; gamma-Aminobutyric Acid; Humans; Infant; Lead; Lea | 1984 |
Electrically elicited seizures from the inferior colliculus: a potential site for the genesis of epilepsy?
Topics: Animals; Chlordiazepoxide; Electric Stimulation; Electrophysiology; Epilepsy; Inferior Colliculi; Ma | 1984 |
Anticonvulsant activity of 4,9-dioxo-5,10-diazatetradecane (CM 40142), a new GABA derivative, in mice and photosensitive baboons).
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Electroshock; Fem | 1984 |
Glycine potentiates the action of some anticonvulsant drugs in some seizure models.
Topics: 3-Mercaptopropionic Acid; Acoustic Stimulation; Animals; Anticonvulsants; Disease Models, Animal; Dr | 1984 |
[Effect of sodium dipropylacetate on experimental convulsions produced by pentetrazole and picrotoxin].
Topics: Animals; Male; Mice; Pentylenetetrazole; Picrotoxin; Seizures; Valproic Acid | 1981 |
Effect of antiepileptic drugs on metrazol convulsions during ontogenesis in the rat.
Topics: Age Factors; Animals; Anticonvulsants; Clonazepam; Ethosuximide; Male; Pentylenetetrazole; Rats; Sei | 1981 |
Anti-epileptic properties of sodium valproate in rat amygdaloid kindling [proceedings].
Topics: Amygdala; Animals; Anticonvulsants; Electric Stimulation; Male; Rats; Seizures; Valproic Acid | 1980 |
Successful prophylaxis against febrile convulsions with valproic acid or phenobarbitone.
Topics: Child, Preschool; Female; Humans; Infant; Male; Phenobarbital; Recurrence; Seizures; Seizures, Febri | 1980 |
Seizure protection and increased nerve-terminal GABA: delayed effects of GABA transaminase inhibition.
Topics: 4-Aminobutyrate Transaminase; Aminocaproates; Aminooxyacetic Acid; Animals; Brain; Cell Compartmenta | 1980 |
Prophylaxis against febrile convulsions.
Topics: Child; Humans; Phenobarbital; Seizures; Seizures, Febrile; Valproic Acid | 1980 |
Prophylaxis against febrile convulsions.
Topics: Chemical and Drug Induced Liver Injury; Child; Humans; Seizures; Seizures, Febrile; Valproic Acid | 1980 |
Seizure management in acute hepatic porphyria: risks of valproate and clonazepam.
Topics: 5-Aminolevulinate Synthetase; Adult; Aminolevulinic Acid; Animals; Benzodiazepinones; Chick Embryo; | 1980 |
Prophylaxis against febrile convulsions.
Topics: Child, Preschool; Diagnosis, Differential; Epilepsy; Humans; Infant; Phenobarbital; Seizures; Seizur | 1980 |
Valproic acid.
Topics: Adult; Drug Therapy, Combination; Humans; Male; Phenobarbital; Phenytoin; Seizures; Valproic Acid | 1980 |
Teratogenicity of valproic acid.
Topics: Abnormalities, Drug-Induced; Female; Humans; Infant, Newborn; Pregnancy; Pregnancy Complications; Se | 1980 |
Antagonism by classical antiepileptics and sodium valproate of cefazolin in induced experimental epilepsy in rats.
Topics: Animals; Anticonvulsants; Behavior, Animal; Cefazolin; Electroencephalography; Rats; Seizures; Valpr | 1980 |
Prevention of simple febrile convulsions.
Topics: Child; Humans; Phenobarbital; Seizures; Seizures, Febrile; Valproic Acid | 1980 |
Continuous sodium valproate or phenobarbitone in the prevention of 'simple' febrile convulsions.
Topics: Humans; Infant; Infant, Newborn; Phenobarbital; Recurrence; Seizures; Seizures, Febrile; Valproic Ac | 1980 |
Prophylaxis and febrile convulsions.
Topics: Child; Child, Preschool; Diazepam; Epilepsy; Humans; Infant; Phenobarbital; Recurrence; Seizures; Se | 1981 |
Febrile convulsions: long-term treatment.
Topics: Anticonvulsants; Child; Child, Preschool; Humans; Infant; Phenobarbital; Prognosis; Recurrence; Seiz | 1981 |
Effects of sodium valproate administered acutely I.V. on human and experimental EEG epileptic foci.
Topics: Animals; Brain; Electroencephalography; Epilepsy; Humans; Rabbits; Seizures; Valproic Acid | 1980 |
Intractable seizures: review and guide for clinical usage of valproic acid.
Topics: Child; Child, Preschool; gamma-Aminobutyric Acid; Humans; Infant; Seizures; Valproic Acid | 1981 |
Studies on gamma-aminobutyric acid transport in cobalt experimental epilepsy in the rat.
Topics: Animals; Biological Transport; Brain; Cobalt; gamma-Aminobutyric Acid; In Vitro Techniques; Kinetics | 1981 |
A comparative study of the pharmacology of inhibitors of GABA-metabolism.
Topics: 4-Aminobutyrate Transaminase; Aminooxyacetic Acid; Animals; Anticonvulsants; Electroshock; Ethanolam | 1980 |
Pharmacologic advances in seizure control.
Topics: Anticonvulsants; Carbamazepine; Child; Clonazepam; Humans; Kinetics; Phenytoin; Seizures; Status Epi | 1981 |
Dissociation between free and bound phenytoin levels in presence of valproate sodium.
Topics: Adult; Drug Interactions; Drug Therapy, Combination; Epilepsies, Myoclonic; Female; Humans; Phenytoi | 1981 |
Valproic acid serum levels and protection against kindled amygdaloid seizures in the rat.
Topics: Amygdala; Animals; Electric Stimulation; Male; Rats; Seizures; Valproic Acid | 1981 |
Drug treatment of epilepsy.
Topics: Anticonvulsants; Carbamazepine; Clonazepam; Electroencephalography; Epilepsy; Ethosuximide; Female; | 1981 |
Valproate in the treatment of seizures associated with propionic acidemia.
Topics: Child; Humans; Male; Propionates; Seizures; Valproic Acid | 1981 |
Effects of some antiepileptic drugs in pentetrazol-induced convulsions in mice lesioned with kainic acid.
Topics: Acetazolamide; Animals; Anticonvulsants; Carbamazepine; Diazepam; Dose-Response Relationship, Drug; | 1981 |
Quantitative evaluation of anticonvulsant effects on penicillin-induced spike foci in cats.
Topics: Animals; Anticonvulsants; Carbamazepine; Cats; Electroencephalography; Ethosuximide; Penicillins; Ph | 1981 |
Valproic acid and secondary hyperammonemia.
Topics: Ammonia; Child; Child, Preschool; Female; Humans; Infant; Seizures; Valproic Acid | 1981 |
Effects of ethyl ester derivatives of valproic acid metabolites on pentylenetetrazol seizures in mice.
Topics: Animals; Drug Administration Schedule; Male; Mice; Mice, Inbred ICR; Pentylenetetrazole; Seizures; V | 1981 |
Only certain anticonvulsants protect against kainate neurotoxicity.
Topics: Animals; Anticonvulsants; Diazepam; Kainic Acid; Male; Nervous System Diseases; Phenobarbital; Pheny | 1981 |
Delirium induced by the competitive interaction between phenytoin and dipropylacetate.
Topics: Adult; Binding, Competitive; Delirium; Drug Interactions; Humans; Male; Phenytoin; Seizures; Valproi | 1981 |
Pure red cell aplasia associated with sodium valproate therapy.
Topics: Anemia, Aplastic; Chickenpox; Child; Female; Humans; Measles; Psychotherapy; Seizures; Time Factors; | 1982 |
[The anti-epileptic effect of valproate, side-effects and toxicity].
Topics: Adolescent; Adult; Child; Female; Humans; Male; Middle Aged; Seizures; Valproic Acid | 1981 |
[Changes in paroxysmal activity in the EEG during valproate (Deprakine, Orfiril) therapy].
Topics: Electroencephalography; Humans; Seizures; Valproic Acid | 1981 |
A proposed mechanism for the anticonvulsant action of valproate.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Brain; Fatty Acids; gamma-Aminobutyric Acid; Glycoge | 1981 |
Analytic study of epileptic absence seizures and effect of sodium valproate treatment.
Topics: Electroencephalography; Epilepsy, Absence; Humans; Seizures; Valproic Acid | 1980 |
Protection from oxygen-induced seizures by clonazepam and propylene glycol.
Topics: Animals; Benzodiazepinones; Carbamazepine; Cats; Clonazepam; Hyperbaric Oxygenation; Polyethylene Gl | 1981 |
[Relation between plasma levels of valproic acid alone and its efficacy and toxicity in pediatric patients under chronic treatment].
Topics: Child; Child, Preschool; Drug Evaluation; Epilepsy; Humans; Infant; Seizures; Seizures, Febrile; Val | 1981 |
Anticonvulsant and antiaggressive properties of di-n-propyl acetate after repeated treatment.
Topics: Acoustic Stimulation; Aggression; Animals; Anticonvulsants; Brain; Female; gamma-Aminobutyric Acid; | 1982 |
Time course of the anticonvulsant effect of valproic acid in young rats.
Topics: Age Factors; Animals; Rats; Seizures; Time Factors; Valproic Acid | 1981 |
Differentiating between organic and functional seizures: a common diagnostic problem.
Topics: Adolescent; Adult; Anticonvulsants; Carbamazepine; Diagnosis, Differential; Dose-Response Relationsh | 1981 |
Sodium valproate and thrombocytopenia.
Topics: Child; Dose-Response Relationship, Drug; Female; Humans; Seizures; Thrombocytopenia; Valproic Acid | 1982 |
Effect of anticonvulsant drugs on kainic acid-induced epileptiform activity.
Topics: Animals; Anticonvulsants; Diazepam; Electroencephalography; Ethosuximide; Guinea Pigs; Hippocampus; | 1982 |
Your role in valproic acid therapy.
Topics: Humans; Seizures; Valproic Acid | 1982 |
Comparative anticonvulsant activity and neurotoxicity of clobazam, diazepam, phenobarbital, and valproate in mice and rats.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Clobazam; Diazepa | 1982 |
Valproic acid and thrombocytopenia. Case report.
Topics: Child, Preschool; Humans; Male; Seizures; Thrombocytopenia; Valproic Acid | 1982 |
The relationship between plasma concentration of valproic acid and its anticonvulsant and behavioural effects in the rat.
Topics: Administration, Oral; Amygdala; Animals; Behavior, Animal; Dose-Response Relationship, Drug; Electro | 1982 |
Bioavailability of rectally administered valproic acid syrup.
Topics: Animals; Biological Availability; Dogs; Dosage Forms; Female; Humans; Infant; Kinetics; Male; Rectum | 1981 |
Interactions between folates and carbamazepine or valproate in the rat.
Topics: Animals; Brain; Carbamazepine; Drug Interactions; Flurothyl; Folic Acid; Leucovorin; Male; Rats; Rat | 1982 |
Asymptomatic hyperammonemia in patients receiving valproic acid.
Topics: Adolescent; Adult; Ammonia; Child; Child, Preschool; Humans; Infant; Seizures; Valproic Acid | 1982 |
Audiogenic seizure-induced changes in energy metabolites in cerebral cortical and cerebellar layers.
Topics: Acoustic Stimulation; Adenosine Triphosphate; Animals; Cerebellum; Cerebral Cortex; Clonazepam; Ener | 1982 |
Isoniazid induced seizures and cerebral cortical and cerebellar energy metabolism.
Topics: Adenosine Triphosphate; Animals; Cerebellar Cortex; Cerebral Cortex; Clonazepam; Energy Metabolism; | 1982 |
EEG quantification of drug level effects in monkey model of partial epilepsy.
Topics: Animals; Anticonvulsants; Circadian Rhythm; Clonazepam; Disease Models, Animal; Electroencephalograp | 1982 |
Pharmacokinetic study of valproic acid in a neonate.
Topics: Age Factors; Humans; Infant, Newborn; Kinetics; Male; Seizures; Time Factors; Valproic Acid | 1982 |
Dose-dependent anticonvulsant and proconvulsant effects of nitric oxide synthase inhibitors on seizure threshold in a cortical stimulation model in rats.
Topics: Amino Acid Oxidoreductases; Analysis of Variance; Animals; Arginine; Cerebral Cortex; Disease Models | 1995 |
[Fatal hepatic necrosis during treatment with sodium valproate].
Topics: Adult; Anticonvulsants; Chemical and Drug Induced Liver Injury; Fatal Outcome; Hepatic Encephalopath | 1995 |
Necrotizing pancreatitis after 10 years of therapy with valproic acid.
Topics: Child; Humans; Male; Necrosis; Pancreatitis; Seizures; Time Factors; Valproic Acid | 1995 |
Kindling increases the sensitivity of rats to adverse effects of certain antiepileptic drugs.
Topics: Animals; Anticonvulsants; Ataxia; Behavior, Animal; Carbolines; Dose-Response Relationship, Drug; Fe | 1995 |
Distribution of unsaturated metabolites of valproate in human and rat brain--pharmacologic relevance?
Topics: Adolescent; Adult; Aged; Animals; Biological Transport; Blood-Brain Barrier; Brain; Brain Chemistry; | 1995 |
Comparison of anticonvulsant efficacy of valproate during prolonged treatment with one and three daily doses or continuous ("controlled release") administration in a model of generalized seizures in rats.
Topics: Animals; Delayed-Action Preparations; Epilepsy, Generalized; Female; Infusions, Intravenous; Pentyle | 1995 |
Effect of antiepileptic drugs on absence-like seizures in the tremor rat.
Topics: Animals; Anticonvulsants; Data Interpretation, Statistical; Drug Therapy, Combination; Electroenceph | 1995 |
Valproic acid effects on serum concentrations of clozapine and norclozapine.
Topics: Clozapine; Depression, Chemical; Drug Therapy, Combination; Humans; Schizophrenia; Seizures; Valproi | 1995 |
Valproic acid and ethosuximide slow the onset of maximal dentate activation in the rat hippocampus.
Topics: Animals; Dose-Response Relationship, Drug; Ethosuximide; Hippocampus; Male; Rats; Rats, Sprague-Dawl | 1994 |
Update on the costs of Depakote and Depakene.
Topics: Cost Savings; Humans; Intellectual Disability; Seizures; Valproic Acid | 1995 |
The significance of extracellular GABA in the substantia nigra of the rat during seizures and anticonvulsant treatments.
Topics: Animals; Anticonvulsants; gamma-Aminobutyric Acid; Male; Microdialysis; Pentylenetetrazole; Rats; Ra | 1995 |
Partial hydranencephaly in a child coincidental with intrauterine exposure to sodium valproate.
Topics: Brain; Female; Humans; Hydranencephaly; Infant; Male; Maternal Welfare; Pregnancy; Prenatal Exposure | 1994 |
Effects of the peptide BCH-325 upon the efficacy of common antiepileptic drugs.
Topics: Amino Acid Sequence; Animals; Anticonvulsants; Carbamazepine; Diazepam; Drug Interactions; Endorphin | 1994 |
Effect of isonicotinic acid hydrazide on extracellular amino acids and convulsions in the rat: reversal of neurochemical and behavioural deficits by sodium valproate.
Topics: Amino Acids; Animals; Aspartic Acid; Extracellular Space; gamma-Aminobutyric Acid; Glutamic Acid; Gl | 1994 |
Clinical and genetic aspects of juvenile absence epilepsy.
Topics: Adolescent; Adult; Child; Electroencephalography; Epilepsy, Absence; Female; Humans; Male; Seizures; | 1994 |
Haematological disturbances during long-term valproate therapy.
Topics: Adolescent; Anemia, Macrocytic; Dermatitis, Atopic; Humans; Male; Seizures; Thrombocytopenia; Valpro | 1994 |
Is the site of action of ethosuximide in the hindbrain?
Topics: Animals; Anticonvulsants; Brain Stem; Clonazepam; Decerebrate State; Electrocardiography; Electroenc | 1994 |
[Effect of sodium valproate, phenobarbital and diazepam during their combined use on convulsions induced by electroshock in mice].
Topics: Animals; Diazepam; Drug Synergism; Drug Therapy, Combination; Electroshock; Mice; Phenobarbital; Sei | 1993 |
Synthesis and evaluation of amino analogues of valproic acid.
Topics: Animals; Anticonvulsants; Electroshock; Injections, Intraperitoneal; Mice; Pentylenetetrazole; Seizu | 1994 |
Concurrent use of clozapine and valproate in affective and psychotic disorders.
Topics: Adult; Clozapine; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Incidence | 1994 |
Valproic acid treatment of clozapine-induced myoclonus.
Topics: Adult; Clozapine; Drug Administration Schedule; Female; Humans; Myoclonus; Receptors, Serotonin; Sch | 1994 |
Competitive antagonists of NMDA receptors, CGP 37849 and CGP 39551, enhance the anticonvulsant activity of valproate against electroconvulsions in mice.
Topics: 2-Amino-5-phosphonovalerate; Animals; Anticonvulsants; Behavior, Animal; Dose-Response Relationship, | 1993 |
Effects of the competitive NMDA receptor antagonist, CGP 37849, on anticonvulsant activity and adverse effects of valproate in amygdala-kindled rats.
Topics: 2-Amino-5-phosphonovalerate; Amygdala; Animals; Anticonvulsants; Ataxia; Female; Kindling, Neurologi | 1993 |
Interaction of lamotrigine with sodium valproate.
Topics: Adult; Aged; Anticonvulsants; Child; Drug Interactions; Drug Therapy, Combination; Female; Humans; L | 1993 |
Involvement of adenosine in postictal events in rats given electroshock.
Topics: Adenosine; Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Electroshock; Female; Hindlimb | 1994 |
Valproate-associated acute pancreatitis in a child with neuronal ceroid lipofuscinosis.
Topics: Acute Disease; Child; Female; Humans; Liver; Neuronal Ceroid-Lipofuscinoses; Pancreatitis; Seizures; | 1994 |
Temporary abolition of seizure activity by flumazenil in a case of valproate-induced non-convulsive status epilepticus.
Topics: Adult; Anticonvulsants; Drug Therapy, Combination; Electroencephalography; Evoked Potentials; Female | 1993 |
Influence of aminophylline and 8-(p-sulfophenyl)theophylline on the anticonvulsive action of diphenylhydantoin, phenobarbital, and valproate against maximal electroshock-induced convulsions in mice.
Topics: Aminophylline; Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electroshock; Male; Mice; | 1993 |
Cross-tolerance between carbamazepine and valproate on amygdala-kindled seizures.
Topics: Amygdala; Animals; Carbamazepine; Drug Tolerance; Kindling, Neurologic; Male; Rats; Rats, Sprague-Da | 1993 |
A new chronic model of spontaneous nonconvulsive generalized seizures.
Topics: 4-Butyrolactone; Animals; Cerebral Cortex; Corpus Callosum; Electroencephalography; Epilepsy, Absenc | 1993 |
Myoclonus and seizures in a patient with parkinsonism: induction by levodopa and its confirmation on SEPs.
Topics: Aged; Electroencephalography; Electromyography; Epilepsies, Myoclonic; Epilepsy, Generalized; Evoked | 1993 |
Anticonvulsant and neurotoxic activities of twelve analogues of valproic acid.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred Strains; Nervou | 1993 |
Preaxial ray reduction defects as part of valproic acid embryofetopathy.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Abortion, Therapeutic; Adolescent; Adult; Extr | 1993 |
A case of Goldenhar syndrome associated with growth hormone deficiency.
Topics: Child; Goldenhar Syndrome; Growth Hormone; Humans; Male; Seizures; Valproic Acid | 1993 |
Treating epilepsy--when, with what and by whom?
Topics: Adult; Epilepsy; Female; Humans; Pregnancy; Pregnancy Complications; Seizures; Valproic Acid | 1993 |
[Lafora disease. Report of a new case diagnosed by biopsy from the axillary skin].
Topics: Axilla; Biopsy; Carbamazepine; Child; Eccrine Glands; Epilepsies, Myoclonic; Epilepsy, Tonic-Clonic; | 1993 |
Search for an antidote to electroconvulsion and lethality in aminophylline-sensitized mice.
Topics: Aminophylline; Animals; Diazepam; Dizocilpine Maleate; Electroshock; Male; Mice; Seizures; Valproic | 1993 |
Antiepileptic drugs--their effects on kindled seizures and kindling-induced learning impairments.
Topics: Animals; Anticonvulsants; Avoidance Learning; Cognition; Dose-Response Relationship, Drug; Ethosuxim | 1995 |
Anticonvulsant activity of phenobarbital and valproate against maximal electroshock in mice during chronic treatment with caffeine and caffeine discontinuation.
Topics: Animals; Anticonvulsants; Caffeine; Electroshock; Male; Mice; Phenobarbital; Seizures; Valproic Acid | 1996 |
Lamotrigine encephalopathy.
Topics: Anticonvulsants; Astrocytoma; Brain Diseases; Brain Neoplasms; Drug Interactions; Female; Frontal Lo | 1996 |
Increasing-current electroshock seizure test: a new method for assessment of anti- and pro-convulsant activities of drugs in mice.
Topics: Analgesics, Opioid; Animals; Anticonvulsants; Carbamazepine; Convulsants; Diazepam; Disease Models, | 1996 |
Immunologically mediated chronic tubulo-interstitial nephritis caused by valproate therapy.
Topics: Anticonvulsants; Biopsy; Child; Complement C3; Fibrosis; Humans; Immunoglobulin G; Kidney; Male; Nep | 1996 |
Gabapentin, valproic acid, and ethanol intoxication: elevated blood levels with mild clinical effects.
Topics: Acetates; Adult; Amines; Anticonvulsants; Cyclohexanecarboxylic Acids; Drug Interactions; Drug Overd | 1996 |
Lamotrigine potentiates the antiseizure activity of some anticonvulsants in DBA/2 mice.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Diazepam; Drug Synergism; Female; Lamotrigine; Male; | 1996 |
Audiogenic seizures following global ischemia induced by chest compression in Long-Evans rats.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Behavior, Animal; Biomechanical Phenomena; Blood Glu | 1996 |
Influence of aminophylline and strychnine on the protective activity of excitatory amino acid antagonists against maximal electroshock-induced convulsions in mice.
Topics: Aminophylline; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Convulsants; Electros | 1996 |
Differential effects of phenytoin and sodium valproate on seizure-induced changes in gamma-aminobutyric acid and glutamate release in vivo.
Topics: Animals; Anticonvulsants; gamma-Aminobutyric Acid; Glutamic Acid; Male; Microdialysis; Phenytoin; Ra | 1995 |
D-23129: a potent anticonvulsant in the amygdala kindling model of complex partial seizures.
Topics: Animals; Anticonvulsants; Carbamates; Female; Kindling, Neurologic; Phenylenediamines; Rats; Rats, W | 1996 |
Carnitine deficiency during valproic acid treatment.
Topics: Adolescent; Anticonvulsants; Carnitine; Child; Child, Preschool; Fatigue; Female; Humans; Infant; Ma | 1995 |
Carnitine deficiency during valproic acid treatment.
Topics: Adolescent; Anticonvulsants; Carnitine; Child; Child, Preschool; Fatigue; Female; Humans; Infant; Ma | 1995 |
Carnitine deficiency during valproic acid treatment.
Topics: Adolescent; Anticonvulsants; Carnitine; Child; Child, Preschool; Fatigue; Female; Humans; Infant; Ma | 1995 |
Carnitine deficiency during valproic acid treatment.
Topics: Adolescent; Anticonvulsants; Carnitine; Child; Child, Preschool; Fatigue; Female; Humans; Infant; Ma | 1995 |
Carnitine deficiency during valproic acid treatment.
Topics: Adolescent; Anticonvulsants; Carnitine; Child; Child, Preschool; Fatigue; Female; Humans; Infant; Ma | 1995 |
Carnitine deficiency during valproic acid treatment.
Topics: Adolescent; Anticonvulsants; Carnitine; Child; Child, Preschool; Fatigue; Female; Humans; Infant; Ma | 1995 |
Carnitine deficiency during valproic acid treatment.
Topics: Adolescent; Anticonvulsants; Carnitine; Child; Child, Preschool; Fatigue; Female; Humans; Infant; Ma | 1995 |
Carnitine deficiency during valproic acid treatment.
Topics: Adolescent; Anticonvulsants; Carnitine; Child; Child, Preschool; Fatigue; Female; Humans; Infant; Ma | 1995 |
Carnitine deficiency during valproic acid treatment.
Topics: Adolescent; Anticonvulsants; Carnitine; Child; Child, Preschool; Fatigue; Female; Humans; Infant; Ma | 1995 |
Neuropsychiatric side effects related to treatment with felbamate.
Topics: Adult; Anticonvulsants; Drug Interactions; Felbamate; Female; Humans; Male; Middle Aged; Phenylcarba | 1996 |
Influence of nicardipine, nimodipine and flunarizine on the anticonvulsant efficacy of antiepileptics against pentylenetetrazol in mice.
Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Clonazepam; Drug Interactions; Ethosuximide; Flu | 1996 |
Valproic-acid-associated pancreatitis and hepatic toxicity in children with endstage renal disease.
Topics: Adolescent; Anticonvulsants; Chemical and Drug Induced Liver Injury; Child; Fatal Outcome; Fatty Liv | 1997 |
Population pharmacokinetics of felbamate in children.
Topics: Adolescent; Anticonvulsants; Carbamazepine; Child; Drug Interactions; Drug Monitoring; Felbamate; Hu | 1997 |
Status epilepticus associated with the combination of valproic acid and clomipramine.
Topics: Adult; Anticonvulsants; Antidepressive Agents, Tricyclic; Clomipramine; Depressive Disorder; Female; | 1997 |
Anticonvulsant activity of novel derivatives of 2- and 3-piperidinecarboxylic acid in mice and rats.
Topics: 4-Aminopyridine; Amygdala; Animals; Anticonvulsants; Brain; Convulsants; Kindling, Neurologic; Male; | 1996 |
Influence of isradipine, niguldipine and dantrolene on the anticonvulsive action of conventional antiepileptics in mice.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1997 |
Effects of valproate on amino acid and monoamine concentrations in striatum of audiogenic seizure-prone Balb/c mice.
Topics: Acoustic Stimulation; Amino Acids; Animals; Anticonvulsants; Biogenic Monoamines; Corpus Striatum; D | 1996 |
Combined valproate or carbamazepine and electroconvulsive therapy.
Topics: Adult; Aged; Aged, 80 and over; Anticonvulsants; Antimanic Agents; Bipolar Disorder; Carbamazepine; | 1997 |
Preclinical characterization of MDL 27,192 as a potential broad spectrum anticonvulsant agent with neuroprotective properties.
Topics: Animals; Anticonvulsants; Cerebral Infarction; Craniocerebral Trauma; Electroshock; Injections, Intr | 1997 |
Long-term outcomes of conventional therapy for infantile spasms.
Topics: Adrenocorticotropic Hormone; Anticonvulsants; Cerebral Palsy; Cognition Disorders; Female; Humans; I | 1997 |
Valproic acid and augmentation of fetal hemoglobin in individuals with and without sickle cell disease.
Topics: Anemia, Sickle Cell; Anticonvulsants; Antisickling Agents; Blood Transfusion; Carbamazepine; Child; | 1997 |
Preliminary evaluation of the anticonvulsant activity of a valproic acid analog: N-(2-propylpentanoyl) urea.
Topics: Animals; Anticonvulsants; Bicuculline; Central Nervous System; Convulsants; Dose-Response Relationsh | 1997 |
Synthesis and pharmacological activity of two derivatives of the amide of valproic acid.
Topics: Animals; Anticonvulsants; Hexobarbital; Hypnotics and Sedatives; Locomotion; Male; Mice; Seizures; S | 1997 |
Elevated free phenytoin and free valproic acid concentrations in sera of patients infected with human immunodeficiency virus.
Topics: Anticonvulsants; Chemistry, Pharmaceutical; HIV Infections; Humans; Phenytoin; Polypharmacy; Seizure | 1998 |
Synergistic effect of flunarizine and sodium valproate on seizure thresholds elicited by cortical stimulation in conscious rats.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Electric Stimulation; Electrodes, Implanted; Flunarizine; | 1998 |
Effect of nimodipine on the efficacy of commonly used antiepileptic drugs in rats.
Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Drug Synergism; Electroshock; Female; Male; Nimo | 1998 |
Anticonvulsant effect of polyunsaturated fatty acids in rats, using the cortical stimulation model.
Topics: Animals; Disease Models, Animal; Docosahexaenoic Acids; Electric Stimulation; Fatty Acids, Unsaturat | 1998 |
Interaction of fluoxetine and valproic acid.
Topics: Adult; Comorbidity; Cytochrome P-450 Enzyme System; Depressive Disorder; Drug Interactions; Female; | 1998 |
The influence of L-NG-nitroarginine methyl ester, an inhibitor of nitric oxide synthase, upon the anticonvulsive activity of conventional antiepileptic drugs against maximal electroshock in mice.
Topics: Animals; Anticonvulsants; Avoidance Learning; Carbamazepine; Drug Antagonism; Electroshock; Enzyme I | 1998 |
Anticonvulsant drug effects in the direct cortical ramp-stimulation model in rats: comparison with conventional seizure models.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Dose-Response Relationship, Drug; E | 1998 |
Effect of non-steroidal anti-inflammatory drugs on the anticonvulsive activity of valproate and diphenylhydantoin against maximal electroshock-induced seizures in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Drug Synergism; Electroshock; Mal | 1998 |
Validation of corneally kindled mice: a sensitive screening model for partial epilepsy in man.
Topics: Amygdala; Animals; Anticonvulsants; Carbamazepine; Cornea; Disease Models, Animal; Dizocilpine Malea | 1998 |
Eyelid myoclonia with absences: phenomenology in children.
Topics: Adaptation, Ocular; Adolescent; Child; Child, Preschool; Diagnosis, Differential; Electroencephalogr | 1998 |
Pathological laughter following intravenous sodium valproate.
Topics: Adolescent; Adult; Anticonvulsants; Humans; Injections, Intravenous; Laughter; Male; Mental Disorder | 1998 |
Additive anticonvulsant effect of flunarizine and sodium valproate on electroshock and chemoshock induced seizures in mice.
Topics: Animals; Anticonvulsants; Carbamazepine; Disease Models, Animal; Drug Interactions; Drug Synergism; | 1998 |
Fatal hyperammonemia in a patient with systemic lupus erythematosus.
Topics: Adult; Ammonia; Anticonvulsants; Brain Diseases; Fatal Outcome; Female; Humans; Kidney Failure, Chro | 1998 |
Potent anticonvulsant paeonimetabolin-I derivatives obtained by incubation of paeoniflorin and thiol compounds with Lactobacillus brevis.
Topics: Animals; Anticonvulsants; Benzoates; Bridged-Ring Compounds; Dose-Response Relationship, Drug; Gluco | 1998 |
Quantifying the costs of serious adverse drug reactions to antiepileptic drugs.
Topics: Adolescent; Adult; Anticonvulsants; Direct Service Costs; Drug Costs; Drug Hypersensitivity; Epileps | 1998 |
Paradoxical response to valproic acid in a patient with a hypothalamic hamartoma.
Topics: Adult; Anticonvulsants; Electroencephalography; Female; Hamartoma; Humans; Hypothalamic Diseases; Se | 1998 |
Effect of clobenpropit, a centrally acting histamine H3-receptor antagonist, on electroshock- and pentylenetetrazol-induced seizures in mice.
Topics: Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Differential Threshold; Electroshock; His | 1998 |
Reversible parkinsonism induced by prolonged treatment with valproate.
Topics: Aged; Anticonvulsants; Antiparkinson Agents; Carbidopa; Female; Humans; Levodopa; Male; Middle Aged; | 1998 |
Pharmacodynamic interaction between phenytoin and sodium valproate changes seizure thresholds and pattern.
Topics: Analysis of Variance; Animals; Anticonvulsants; Drug Interactions; Male; Phenytoin; Rats; Rats, Wist | 1998 |
N(G)-nitro-L-arginine impairs the anticonvulsive action of ethosuximide against pentylenetetrazol.
Topics: Animals; Anticonvulsants; Arginine; Convulsants; Diazepam; Drug Interactions; Enzyme Inhibitors; Eth | 1999 |
Characterization of seizures in the flathead rat: a new genetic model of epilepsy in early postnatal development.
Topics: Animals; Anticonvulsants; Behavior, Animal; Brain; Cerebral Cortex; Disease Models, Animal; Electroe | 1999 |
Effect of theophylline on diazepam and sodium valproate protection in pentylenetetrazole - kindled seizures in rats.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Drug Interactions; Male; Pentylenetetrazole; Protec | 1997 |
Use of intravenous valproate in three pediatric patients with nonconvulsive or convulsive status epilepticus.
Topics: Anticonvulsants; Child; Child, Preschool; Drug Administration Schedule; Drug Interactions; Enzyme In | 1999 |
Distinct features of seizures induced by cocaine and amphetamine analogs.
Topics: Animals; Central Nervous System Agents; Central Nervous System Stimulants; Diazepam; Dose-Response R | 1999 |
Generalized onycholysis associated with sodium valproate therapy.
Topics: Anticonvulsants; Child, Preschool; Fingers; Humans; Male; Nail Diseases; Seizures; Toes; Valproic Ac | 1999 |
Age-specific N-methyl-D-aspartate-induced seizures: perspectives for the West syndrome model.
Topics: Age Factors; Animals; Behavior, Animal; Disease Models, Animal; Electroencephalography; Humans; Hydr | 1999 |
Anticonvulsant profile of nimodipine and nitrendipine against pentylenetetrazole induced seizures in rats.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Male; | 1999 |
The role of technical, biological, and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. VII. Seasonal influences on anticonvulsant drug actions in mouse models of generalized seizures.
Topics: Animals; Anticonvulsants; Carbamazepine; Dose-Response Relationship, Drug; Drug Evaluation, Preclini | 2000 |
A child with a DIC (15p; 22p) centric fusion and fetal Valproate syndrome.
Topics: Abnormalities, Multiple; Adult; Chromosome Aberrations; Chromosomes, Human, Pair 15; Chromosomes, Hu | 1999 |
Effects of anticonvulsants on local anaesthetic-induced neurotoxicity in rats.
Topics: Anesthetics, Local; Animals; Anticonvulsants; Benzodiazepines; Brain; Drug Synergism; Lidocaine; Mal | 2000 |
Tolerance to the anticonvulsant effects of lamotrigine on amygdala kindled seizures: cross-tolerance to carbamazepine but not valproate or diazepam.
Topics: Amygdala; Animals; Anticonvulsants; Carbamazepine; Diazepam; Disease Models, Animal; Dose-Response R | 2000 |
Acute and chronic effects of the synthetic neuroactive steroid, ganaxolone, against the convulsive and lethal effects of pentylenetetrazol in seizure-kindled mice: comparison with diazepam and valproate.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Dose-Response Relationship, Drug; Kindling, Neurolo | 2000 |
Participation of GABAergic and histaminergic systems in inhibiting amygdaloid kindled seizures.
Topics: Amygdala; Animals; Bicuculline; Diazepam; gamma-Aminobutyric Acid; Histamine; Imidazoles; Kindling, | 2000 |
Enhanced anticonvulsant activity of ganaxolone after neurosteroid withdrawal in a rat model of catamenial epilepsy.
Topics: Animals; Anticonvulsants; Convulsants; Diazepam; Disease Models, Animal; Enzyme Inhibitors; Epilepsy | 2000 |
Valproate-induced hyperammonemic encephalopathy in the presence of topiramate.
Topics: Adolescent; Ammonia; Anticonvulsants; Drug Therapy, Combination; Electroencephalography; Female; Fru | 2000 |
Prolonged toxic epidermal necrolysis due to Lamotrigine.
Topics: Adult; Anticonvulsants; Drug Interactions; Humans; Lamotrigine; Male; Seizures; Stevens-Johnson Synd | 2000 |
Influence of chronic barbiturate administration on sleep apnea after hypersomnia presentation: case study.
Topics: Adult; Anticonvulsants; Bipolar Disorder; Disorders of Excessive Somnolence; Dose-Response Relations | 2000 |
4-Hydroxybenzaldehyde from Gastrodia elata B1. is active in the antioxidation and GABAergic neuromodulation of the rat brain.
Topics: 4-Aminobutyrate Transaminase; Animals; Anticonvulsants; Benzaldehydes; Brain; Convulsants; gamma-Ami | 2000 |
Protein C deficiency related to valproic acid therapy: a possible association with childhood stroke.
Topics: Anticonvulsants; Antithrombins; Child; Child, Preschool; Female; Fibrinogen; Humans; Infant; Platele | 2000 |
Sodium valproate alters GnRH-GABA interactions during development in seizure-prone mice.
Topics: Animals; Anticonvulsants; gamma-Aminobutyric Acid; Gonadotropin-Releasing Hormone; Humans; Male; Mic | 2000 |
Intravenous valproate dosing in neonates.
Topics: Anticonvulsants; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Inf | 2000 |
Glutamate receptor antagonists differentially affect the protective activity of conventional antiepileptics against amygdala-kindled seizures in rats.
Topics: Amygdala; Animals; Anticonvulsants; Carbamazepine; Excitatory Amino Acid Antagonists; Kindling, Neur | 2001 |
A case of chronic pancreatic insufficiency due to valproic acid in a child.
Topics: Adolescent; Anticonvulsants; Chronic Disease; Exocrine Pancreatic Insufficiency; Follow-Up Studies; | 2001 |
Anticonvulsant activity of N-palmitoylethanolamide, a putative endocannabinoid, in mice.
Topics: Amides; Animals; Anticonvulsants; Cannabinoid Receptor Modulators; Cannabinoids; Convulsants; Diseas | 2001 |
Stereoselective pharmacokinetic analysis and antiepileptic activity of N-2-hydroxypropyl valpromide, a central nervous system--active chiral valproylamide.
Topics: Animals; Anticonvulsants; Brain; Dogs; Drug Evaluation, Preclinical; Rats; Rats, Sprague-Dawley; Sei | 2001 |
[Cerebral vasculitis as the initial manifestation of systemic lupus erythematosus].
Topics: Adult; Antibodies, Antinuclear; Anticoagulants; Anticonvulsants; Biopsy; Brain; Humans; Immunosuppre | 2001 |
Effect of alkylpyrazine derivatives on the duration of pentobarbital-induced sleep, picrotoxicin-induced convulsion and gamma-aminobutyric acid (GABA) levels in the mouse brain.
Topics: Aminooxyacetic Acid; Animals; Anticonvulsants; Bicuculline; Brain Chemistry; Convulsants; Diazepam; | 2001 |
Synthesis of valproic acid amides of a melatonin derivative, a piracetam and amantadine for biological tests.
Topics: Amantadine; Animals; Melatonin; Pentylenetetrazole; Piracetam; Rodentia; Seizures; Valproic Acid | 2001 |
Comparison of the anticonvulsant efficacies and neurotoxic effects of valproic acid, phenytoin, and the ketogenic diet.
Topics: 3-Hydroxybutyric Acid; Animals; Anticonvulsants; Dietary Fats; Electroencephalography; Energy Intake | 2001 |
Aspirin modulates the anticonvulsant effect of diazepam and sodium valproate in pentylenetetrazole and maximal electroshock induced seizures in mice.
Topics: Animals; Anticonvulsants; Aspirin; Diazepam; Male; Mice; Pentylenetetrazole; Prostaglandins; Seizure | 2001 |
Unmasking of absence seizures by carbamazepine.
Topics: Anticonvulsants; Carbamazepine; Child, Preschool; Electroencephalography; Female; Follow-Up Studies; | 2002 |
[Treatment of epileptic seizures resistant to phenobarbital in children during the first year of life].
Topics: Anticonvulsants; Drug Resistance; Epilepsy; Humans; Infant; Phenobarbital; Prospective Studies; Seiz | 2002 |
Influence on ictal seizure semiology of rapid withdrawal of carbamazepine and valproate in monotherapy.
Topics: Adult; Anticonvulsants; Automatism; Carbamazepine; Female; Humans; Male; Middle Aged; Movement Disor | 2002 |
Molsidomine enhances the protective activity of valproate against pentylenetetrazole-induced seizures in mice.
Topics: Animals; Anticonvulsants; Convulsants; Drug Synergism; Male; Mice; Molsidomine; Pentylenetetrazole; | 2002 |
Protocols for identifying drug-nutrient interactions in patients: the role of the dietitian.
Topics: Adolescent; Adult; Anticonvulsants; Biotin; Calcium; Carnitine; Dietetics; Edema; Folic Acid; Food-D | 2002 |
Valproic acid therapy inducing absence status evolving into generalized seizures.
Topics: Anticonvulsants; Child; Child, Preschool; Female; Humans; Male; Seizures; Status Epilepticus; Valpro | 2002 |
Proceedings: The kindling effect in the cat and the rat: neurophysiological and neuropharmacological approach.
Topics: Animals; Cats; Rats; Seizures; Sleep Stages; Valproic Acid | 1975 |
Pancreatitis due to valproic acid.
Topics: Child; Child, Preschool; Female; Gastritis; Humans; Male; Pancreatitis; Seizures; Valproic Acid | 1979 |
Effect of valproate sodium on generalized penicillin epilepsy in the cat.
Topics: Animals; Brain; Cats; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalograp | 1978 |
Sodium valproate (Epilim) in epilepsy: a trial.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Epilepsy; Epilepsy, Absence; Epilepsy, Tonic-Cloni | 1978 |
Absence status and the concurrent administration of clonazepam and valproate sodium.
Topics: Benzodiazepinones; Clonazepam; Drug Interactions; Drug Therapy, Combination; Epilepsy, Absence; Huma | 1979 |
Neutropenia during sodium valproate treatment.
Topics: Agranulocytosis; Humans; Infant; Male; Neutropenia; Seizures; Valproic Acid | 1979 |
Febrile seizures and thalamocortical activity: a comparison of effects of valproate and phenytoin.
Topics: Animals; Cats; Cerebral Cortex; Neural Pathways; Phenytoin; Seizures; Seizures, Febrile; Thalamus; V | 1979 |
[Hyperbaric oxygen: effect of sodium dipropylacetate and dipropylacetamine on convulsion seizures and pulmonary lesions in the mouse].
Topics: Acetamides; Animals; Hyperbaric Oxygenation; Mice; Pulmonary Edema; Seizures; Valerates; Valproic Ac | 1975 |
Metabolite levels in brain following experimental seizures: the effects of isoniazid and sodium valproate in cerebellar and cerebral cortical layers.
Topics: Animals; Brain; Cerebellum; Cerebral Cortex; Cyclic AMP; Cyclic GMP; gamma-Aminobutyric Acid; Glucos | 1979 |
A study of the action of valproic acid on the kindling effect.
Topics: Amygdala; Animals; Cats; Electric Stimulation; Male; Phenobarbital; Seizures; Valerates; Valproic Ac | 1977 |
[Study of the immunosuppressive effect of some anticonvulsants in children].
Topics: Adolescent; Anticonvulsants; B-Lymphocytes; Child; Child, Preschool; Epilepsy; Female; Humans; Immun | 1977 |
Sodium valproate: a new anticonvulsant.
Topics: Drug Interactions; Humans; Seizures; Valerates; Valproic Acid | 1977 |
Effects of alterations in the metabolism of gamma-aminobutyrate on convulsant potencies.
Topics: 3-Mercaptopropionic Acid; Aminobutyrates; Aminooxyacetic Acid; Animals; Bicuculline; Diacetyl; Drug | 1977 |
A comparative study of the efficacy of newer antiepiletpic drugs on experimentally-induced febrile convulsions.
Topics: Animals; Anticonvulsants; Body Temperature; Carbamazepine; Clonazepam; Male; Mice; Phenobarbital; Se | 1977 |
[Prophylactic and anticonvulsive effects of di--N--propylacetate examined in kindling cat preparations (author's transl)].
Topics: Amygdala; Animals; Cats; Disease Models, Animal; Drug Evaluation, Preclinical; Electric Stimulation; | 1977 |
Influence of a GABA transaminase inhibitor on central nervous system oxygen toxicity.
Topics: 4-Aminobutyrate Transaminase; Animals; Electroencephalography; Hyperbaric Oxygenation; Male; Rats; S | 1978 |
The effect of sodium dipropylacetate on experimental spike foci.
Topics: Animals; Brain; Cats; Electroencephalography; Seizures; Valerates; Valproic Acid | 1977 |
Transient thrombocytopenia in a child on sodium valproate.
Topics: Child; Female; Humans; Remission, Spontaneous; Respiratory Tract Infections; Seizures; Thrombocytope | 1978 |
Effect of n-dipropylacetate on amino acid concentrations in mouse brain: correlations with anti-convulsant activity.
Topics: Animals; Aspartic Acid; Brain; Female; gamma-Aminobutyric Acid; Kinetics; Male; Mice; Noise; Seizure | 1978 |
[Simultaneous estimation of phenobarbitone and valproic acid in the plasma by high performance liquid chromatography (author's transl)].
Topics: Chromatography, Gas; Chromatography, High Pressure Liquid; Colorimetry; Humans; Phenobarbital; Seizu | 1978 |
Sodium bromide and sodium valproate: effective suppressants of ethanol withdrawal reactions in mice.
Topics: Alcoholism; Animals; Bromides; Dose-Response Relationship, Drug; Humans; Male; Mice; Postural Balanc | 1979 |
The delayed effect of sodium valproate on the photoconvulsive response in man.
Topics: Adolescent; Adult; Electroencephalography; Female; Humans; Male; Middle Aged; Photic Stimulation; Se | 1979 |
Valproate sodium in refractory seizures: a study of efficacy.
Topics: Adolescent; Adult; Child; Child, Preschool; Humans; Seizures; Valproic Acid | 1979 |
Neurology.
Topics: Cerebrovascular Disorders; Humans; Neurology; Seizures; Valproic Acid | 1979 |
The drug of choice for major seizures?
Topics: Carbamazepine; Decision Making; Humans; Phenytoin; Seizures; Valproic Acid | 1979 |
Sodium valproate in the prophylaxis of simple febrile convulsions.
Topics: Chemical and Drug Induced Liver Injury; Child; Child, Preschool; Drug Evaluation; Fever; Gastrointes | 1979 |
Combination of clonazepam and sodium valproate in the treatment of refractory epileptic seizures in 12 children.
Topics: Benzodiazepinones; Child; Clonazepam; Drug Therapy, Combination; Epilepsy; Humans; Seizures; Valproi | 1979 |
Facilitation of bicuculline- and picrotoxin-induced seizures by sodium valproate in rats.
Topics: Animals; Bicuculline; Drug Synergism; Male; Picrotoxin; Rats; Seizures; Valproic Acid | 1979 |
Sodium valproate: serial monitoring of EEG and serum levels.
Topics: Adolescent; Adult; Brain Diseases; Electroencephalography; Female; Humans; Middle Aged; Seizures; Va | 1979 |
[The serum concentration of anticonvulsants -- pharmacokinetic findings and practical therapeutic applications (author's transl)].
Topics: Antacids; Anticonvulsants; Biological Availability; Carbamazepine; Chromatography, Gas; Clonazepam; | 1979 |
Involvement of central GABA-ergic systems in convulsions and aggressive behavior.
Topics: 4-Aminobutyrate Transaminase; Aggression; Allylglycine; Animals; Bicuculline; Brain; Fatty Acids; ga | 1979 |
Effect of anticonvulsants on cortical focal seizure in cats.
Topics: Acetazolamide; Animals; Anticonvulsants; Carbamazepine; Cats; Diazepam; Electrocardiography; Epileps | 1977 |
Efficacy testing of valproic acid compared to ethosuximide in monkey model: I. Dosage regimen design in the presence of diurnal oscillations.
Topics: Animals; Biopharmaceutics; Circadian Rhythm; Disease Models, Animal; Ethosuximide; Haplorhini; Macac | 1977 |
Efficacy testing of valproic acid compared to ethosuximide in monkey model: II. Seizure, EEG, and diurnal variations.
Topics: Animals; Circadian Rhythm; Disease Models, Animal; Electroencephalography; Ethosuximide; Haplorhini; | 1977 |
Anticonvulsant action of ethanolamine-O-sulphate and di-n-propylacetate and the metabolism of gamma-aminobutyric acid (GABA) in mice with audiogenic seizures.
Topics: 4-Aminobutyrate Transaminase; Acoustic Stimulation; Aldehyde Oxidoreductases; Aminobutyrates; Animal | 1976 |
Di-n-propylacetic acid--profile of anticonvulsant activity in mice.
Topics: Animals; Anticonvulsants; Bicuculline; Dose-Response Relationship, Drug; Electroshock; Ethosuximide; | 1976 |
The modification of the ethanol withdrawal syndrome in rats by di-n-propylacetate.
Topics: Acoustic Stimulation; Alcoholism; Animals; gamma-Aminobutyric Acid; Humans; Male; Motor Activity; Ra | 1976 |
Effects of chronic treatment with amino-oxyacetic acid or sodium n-dipropylacetate on brain GABA levels and the development and regression of cobalt epileptic foci in rats.
Topics: 4-Aminobutyrate Transaminase; Acetates; Aminobutyrates; Aminooxyacetic Acid; Animals; Brain; Brain C | 1976 |
Effect of drug-induced increase of brain GABA levels on penicillin focus.
Topics: Acetates; Action Potentials; Aminobutyrates; Aminooxyacetic Acid; Animals; Brain Chemistry; Cats; Ce | 1975 |
The prevention of ethanol withdrawal seizures in rats by dipropylacetate.
Topics: Alcohol Drinking; Analgesia; Animals; Ethanol; Humans; Male; Rats; Seizures; Substance Withdrawal Sy | 1975 |
Increased cortical excitability in generalised epilepsy demonstrated with transcranial magnetic stimulation.
Topics: Cerebral Cortex; Electric Stimulation; Epilepsy; Humans; Seizures; Transcranial Magnetic Stimulation | 1992 |
Kindled rats are more sensitive than non-kindled rats to the behavioural effects of combined treatment with MK-801 and valproate.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dizocilpine Maleate; Drug Synergism; Female; Kindling, Neurolo | 1992 |
Suppression of experimental barbiturate and phenytoin withdrawal syndrome using valproate sodium.
Topics: Animals; Barbiturates; Male; Phenytoin; Rats; Rats, Wistar; Seizures; Substance Withdrawal Syndrome; | 1992 |
Effects of some calcium antagonists upon the activity of common antiepileptic compounds on sound-induced seizures in DBA/2 mice.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl e | 1992 |
Serum valproate concentrations and control of seizures.
Topics: Child; Humans; Seizures; Valproic Acid | 1992 |
Antiparkinsonian drugs memantine and trihexyphenidyl potentiate the anticonvulsant activity of valproate against maximal electroshock-induced seizures.
Topics: Animals; Anticonvulsants; Antiparkinson Agents; Avoidance Learning; Drug Synergism; Electroshock; Ma | 1992 |
Comparison of anticonvulsant effects of valproic acid entrapped in positively and negatively charged liposomes in amygdaloid-kindled rats.
Topics: Amygdala; Animals; Drug Carriers; Injections, Intraperitoneal; Kindling, Neurologic; Liposomes; Male | 1992 |
Cerebral cavernous angioma: a potentially benign condition? Successful treatment in 16 cases.
Topics: Adolescent; Adult; Angiography; Brain Neoplasms; Carbamazepine; Cerebral Hemorrhage; Child; Epilepsy | 1992 |
Intravenous valproate: onset and duration of anticonvulsant activity against a series of electroconvulsions in comparison with diazepam and phenytoin.
Topics: Animals; Anticonvulsants; Diazepam; Electric Stimulation; Electroshock; Epilepsy, Tonic-Clonic; Inje | 1992 |
Age dependency of the susceptibility of rats to aminooxyacetic acid seizures.
Topics: Aging; Aminooxyacetic Acid; Animals; Anticonvulsants; Body Temperature; Brain; Carbamazepine; Clonaz | 1992 |
Abnormal metabolism of carnitine and valproate in a case of acute encephalopathy during chronic valproate therapy.
Topics: Brain Diseases; Carnitine; Cerebral Palsy; Child; Chronic Disease; Female; Gas Chromatography-Mass S | 1992 |
Valproate use associated with persistent hyperammonemia and mitochondrial injury in a child with Down's syndrome.
Topics: Ammonia; Bone Marrow; Child, Preschool; Down Syndrome; Follow-Up Studies; Humans; Liver; Male; Mitoc | 1992 |
Terminal deletion of chromosome 4p (4p16.3) shows a breakpoint between loci linked to Huntington disease.
Topics: Abnormalities, Multiple; Adolescent; Chromosome Banding; Chromosome Deletion; Chromosomes, Human, Pa | 1992 |
Tolerance to the anticonvulsant effects of carbamazepine, diazepam, and sodium valproate in kindled rats.
Topics: Amygdala; Animals; Anticonvulsants; Brain; Carbamazepine; Diazepam; Drug Tolerance; Electrodes, Impl | 1992 |
Low and variable presence of valproic acid in human brain.
Topics: Adolescent; Adult; Aged; Brain Chemistry; Child; Female; Humans; Male; Middle Aged; Seizures; Valpro | 1992 |
Heterozygote ornithine transcarbamylase deficiency presenting as symptomatic hyperammonemia during initiation of valproate therapy.
Topics: Adult; Ammonia; Female; Heterozygote; Humans; Metabolic Diseases; Ornithine Carbamoyltransferase Def | 1992 |
Cocaine-induced respiratory depression and seizures are synergistic mechanisms of cocaine-induced death in rats.
Topics: Animals; Cocaine; Death; Dizocilpine Maleate; Drug Synergism; Electrocardiography; Electroencephalog | 1992 |
Antiepileptic drugs delay the onset of seizures induced by aminophylline in conscious rats.
Topics: Aminophylline; Anesthesia; Animals; Anticonvulsants; Carbamazepine; Consciousness; Diazepam; Electro | 1992 |
Interactions between angiotensin II, diazepam, clonazepam and di-n-propylacetate in pentylenetetrazol kindling seizures in mice.
Topics: Angiotensin II; Animals; Clonazepam; Diazepam; Drug Interactions; Electric Stimulation; Ionophores; | 1991 |
Anticonvulsive effect and neuromediator changes in rat's brain treated with sodium valproate.
Topics: Animals; Brain; Male; Neurotransmitter Agents; Rats; Rats, Wistar; Seizures; Valproic Acid | 1991 |
Influence of MK-801 on the anticonvulsant activity of antiepileptics.
Topics: Animals; Anticonvulsants; Behavior, Animal; Dizocilpine Maleate; Drug Synergism; Electroshock; Learn | 1991 |
Anticonvulsant activity of the imidazoline 6,7-benzoidazoxan.
Topics: Animals; Anticonvulsants; Behavior, Animal; Bicuculline; Dioxanes; Electroshock; Imidazoles; Male; M | 1991 |
Comparison of valproate concentrations in human plasma, CSF and brain tissue after administration of different formulations of valproate or valpromide.
Topics: Adolescent; Adult; Brain; Electroencephalography; Female; Humans; Male; Seizures; Valproic Acid | 1991 |
Influence of antidepressant drugs on seizure susceptibility and the anticonvulsant activity of valproate in mice.
Topics: Amitriptyline; Animals; Desipramine; Dose-Response Relationship, Drug; Electroshock; Imipramine; Mal | 1991 |
Incidental microvesicular steatosis due to valproic acid anticonvulsant therapy.
Topics: Adult; Fatty Liver; Hepatitis C; Hepatitis, Chronic; Humans; Male; Seizures; Valproic Acid | 1991 |
Myoclonic epilepsy--pitfalls in diagnosis and management.
Topics: Adolescent; Adult; Carbamazepine; Diagnosis, Differential; Epilepsies, Myoclonic; Female; Humans; Ma | 1991 |
On the development of alternative antiepileptic drugs. Lack of enantioselectivity of the anticonvulsant activity, in contrast to teratogenicity, of 2-n-propyl-4-pentenoic acid and 2-n-propyl-4-pentynoic acid, analogues of the anticonvulsant drug valproic
Topics: Animals; Anticonvulsants; Drug Design; Fatty Acids, Monounsaturated; Fatty Acids, Unsaturated; Femal | 1991 |
The fetal valproate syndrome.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Child, Preschool; Face; Female; Humans; Male; | 1991 |
Reduction of serum carnitine concentrations during anticonvulsant therapy with phenobarbital, valproic acid, phenytoin, and carbamazepine in children.
Topics: Analysis of Variance; Carbamazepine; Carnitine; Child; Drug Combinations; Fatty Acids; Fatty Acids, | 1991 |
Death of a hepatitis A patient during valproate therapy.
Topics: Adult; Female; Hepatitis A; Humans; Prognosis; Seizures; Valproic Acid | 1991 |
Kainic acid induced epileptogenesis in developing normal & undernourished rats--a computerised EEG analysis.
Topics: Age Factors; Animals; Cerebellum; Electroencephalography; Glycine; Hippocampus; Kainic Acid; Nutriti | 1990 |
Depression, anxiety, and temporal lobe epilepsy. Laterality of focus and symptoms.
Topics: Adult; Analysis of Variance; Anxiety; Carbamazepine; Depression; Epilepsy, Temporal Lobe; Female; Fu | 1990 |
In vivo determination of valproate binding constants during sole and multi-drug therapy.
Topics: Binding, Competitive; Carbamazepine; Drug Therapy, Combination; Food; Humans; Phenytoin; Seizures; V | 1990 |
[Interaction of valproic acid and erythromycin].
Topics: Child, Preschool; Drug Interactions; Erythromycin; Female; Fever; Humans; Seizures; Valproic Acid | 1990 |
The high incidence of valproate hepatotoxicity in infants may relate to familial metabolic defects.
Topics: Chemical and Drug Induced Liver Injury; Humans; Infant; Liver Diseases; Male; Metabolism, Inborn Err | 1990 |
Differential effects of agents enhancing purinergic transmission upon the antielectroshock efficacy of carbamazepine, diphenylhydantoin, diazepam, phenobarbital, and valproate in mice.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Anticonvulsants; Body Temperature Regulation; | 1990 |
Seizure susceptibility & intra rectal sodium valproate induced recovery in developing undernourished rats.
Topics: Administration, Rectal; Animals; Animals, Newborn; Differential Threshold; Disease Susceptibility; N | 1990 |
Metabolic profiling of valproic acid in patients using negative-ion chemical ionization gas chromatography-mass spectrometry.
Topics: Adolescent; Adult; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Carbamazepine; Child; Ch | 1990 |
Antiepileptic medications.
Topics: Anticonvulsants; Barbiturates; Carbamazepine; Dental Care for Disabled; Epilepsy; Humans; Hydantoins | 1990 |
Influence of calcium channel inhibitors upon the anticonvulsant efficacy of common antiepileptics against pentylenetetrazol-induced convulsions in mice.
Topics: Animals; Anticonvulsants; Calcium Channel Blockers; Diltiazem; Drug Therapy, Combination; Ethosuximi | 1990 |
Excipients in valproic acid syrup may cause diarrhea: a case report.
Topics: Child, Preschool; Diarrhea; Excipients; Humans; Male; Seizures; Tablets, Enteric-Coated; Valproic Ac | 1990 |
Anticonvulsant drug mechanisms of action.
Topics: Action Potentials; Animals; Anticonvulsants; Barbiturates; Benzodiazepines; Carbamazepine; Clonazepa | 1985 |
[Serum concentration of valproic acid after rectal administration].
Topics: Administration, Rectal; Adolescent; Adult; Aged; Craniocerebral Trauma; Female; Humans; Male; Middle | 1988 |
Valproic acid, unlike other anticonvulsants, has no effect on methadone metabolism: two cases.
Topics: Adult; Drug Therapy, Combination; Heroin Dependence; Humans; Male; Methadone; Middle Aged; Phenytoin | 1989 |
Carnitine deficiency associated with anticonvulsant therapy.
Topics: Adolescent; Adult; Aged; Anticonvulsants; Carbamazepine; Carnitine; Cerebral Palsy; Drug Therapy, Co | 1989 |
[Cyclosporin and convulsions after cardiac transplantation].
Topics: Adolescent; Adult; Cyclosporins; Female; Heart Transplantation; Humans; Immunosuppression Therapy; M | 1989 |
Influence of clonazepam and valproate on kainate-induced model of psychomotor seizures.
Topics: Animals; Anticonvulsants; Clonazepam; Kainic Acid; Rats; Seizures; Valproic Acid | 1989 |
Chronotoxicity of sodium valproate and its mechanisms in mice: dose-concentration-response relationship.
Topics: Animals; Circadian Rhythm; Dose-Response Relationship, Drug; Electroshock; Male; Mice; Mice, Inbred | 1989 |
Usefulness of a single-dose prediction model for the determination of long-term maintenance therapy of valproic acid.
Topics: Child; Child, Preschool; Chromatography, Gas; Female; Humans; Male; Models, Biological; Predictive V | 1989 |
[Factors influencing the effectiveness of preventive treatment of febrile convulsions].
Topics: Anticonvulsants; Child; Drug Evaluation; Epilepsy; Female; Fever; Humans; Male; Phenobarbital; Primi | 1989 |
Antimetrazol action and plasma levels of valproate in developing rats.
Topics: Aging; Animals; Male; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures; Time Factors; Valpro | 1989 |
[Anticonvulsive properties of peptide ACTH4-7 pro-gly-pro detected in amygdaloid kindling and audiogenic epilepsy in rats].
Topics: Acoustic Stimulation; Adrenocorticotropic Hormone; Amygdala; Animals; Anticonvulsants; Delayed-Actio | 1989 |
Effect of magnesium valproate on amygdala-kindled seizures in the rat: comparison with sodium valproate.
Topics: Animals; Anticonvulsants; Dose-Response Relationship, Drug; Electric Stimulation; Kindling, Neurolog | 1989 |
Inhibition of aminophylline-induced convulsions in mice by antiepileptic drugs and other agents.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Aminophylline; Animals; Anticonvulsants; Aspartic Acid; Di | 1987 |
Effect of anticonvulsants on pentylenetetrazol-induced power spectrum changes in electroencephalograms in rats.
Topics: Animals; Anticonvulsants; Cerebral Cortex; Cyclic AMP; Electroencephalography; Ethosuximide; Male; P | 1987 |
Etifoxine: evaluation of its anticonvulsant profile in mice in comparison with sodium valproate, phenytoin and clobazam.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Clobazam; Electro | 1985 |
Effects of carbamazepine and valproic acid on brain immunoreactive somatostatin and gamma-aminobutyric acid in amygdaloid-kindled rats.
Topics: Amygdala; Animals; Brain Chemistry; Carbamazepine; gamma-Aminobutyric Acid; Kindling, Neurologic; Ma | 1986 |
The role of GABA and excitatory amino acids in the development of the leptazol-induced epileptogenic EEG.
Topics: Allylglycine; Amino Acids; Animals; Bicuculline; Cerebral Cortex; Clonazepam; Dose-Response Relation | 1986 |
[Effect of diazepam, carbamazepine, sodium valproate and their combinations with vitamin preparations on epileptic activity].
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Drug Therapy, Combination; Male; Niacinamide; Pen | 1985 |
Anticonvulsant drugs effective against human temporal lobe epilepsy prevent seizures but not neurotoxicity induced in rats by quinolinic acid: electroencephalographic, behavioral and histological assessments.
Topics: Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Chlorpromazine; Diazepam; Disease Models, | 1986 |
The effect of antiepileptic drugs. II. (Valproate, methsuximide) on nonesterified fatty acids in the brain structures during convulsive state.
Topics: Animals; Anticonvulsants; Brain; Fatty Acids, Nonesterified; Male; Rats; Rats, Inbred Strains; Seizu | 1987 |
Non involvement of gamma-aminobutyric acid in catechol-induced seizures.
Topics: Animals; Carbachol; Diazepam; Female; gamma-Aminobutyric Acid; Mice; Muscles; Phenobarbital; Picroto | 1986 |
Role of the substantia nigra in GABA-mediated anticonvulsant actions.
Topics: Aminocaproates; Aminooxyacetic Acid; Animals; Anticonvulsants; Brain; Brain Diseases; Denervation; D | 1986 |
The effects of beta-carboline carboxylic acid ethyl ester and its free acid, administered ICV, on the anticonvulsant activity of diazepam and sodium valproate in the mouse.
Topics: Animals; Benzodiazepinones; Carbolines; Diazepam; Drug Interactions; Female; Mice; Mice, Inbred C3H; | 1986 |
[The correlation between concentrations of anticonvulsive drugs in the brain and various parameters of maximal electroshock seizures in mice].
Topics: Animals; Anticonvulsants; Brain Chemistry; Carbamazepine; Drug Evaluation, Preclinical; Electroshock | 1986 |
Sodium valproate, but not ethosuximide, produces use- and voltage-dependent limitation of high frequency repetitive firing of action potentials of mouse central neurons in cell culture.
Topics: Action Potentials; Animals; Carbamazepine; Cells, Cultured; Cerebral Cortex; Dose-Response Relations | 1986 |
Prenatal antiepileptic drug exposure alters seizure susceptibility in rats.
Topics: Animals; Anticonvulsants; Brain Chemistry; Clonazepam; Female; Male; Motor Activity; Phenobarbital; | 1986 |
Free and total serum valproate concentrations: their relationship to seizure control, liver enzymes and plasma ammonia in children.
Topics: Adolescent; Adult; Ammonia; Aspartate Aminotransferases; Child; Child, Preschool; Humans; Infant; Li | 1986 |
The clinical significance of metal binding in convulsion control with sodium valproate.
Topics: Chemical Phenomena; Chemistry; Copper; Humans; Mass Spectrometry; Metals; Seizures; Spectrophotometr | 1986 |
Potentiation of clobazam's anticonvulsant activity by etifoxine, a non-benzodiazepine tranquilizer, in mice. Comparison studies with sodium valproate.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Clobazam; Drug Sy | 1986 |
Hemorrhagic pancreatitis in a young child following valproic acid therapy. Clinical and ultrasonic assessment.
Topics: Acute Disease; Child, Preschool; Hemorrhage; Humans; Male; Pancreatitis; Seizures; Ultrasonography; | 1987 |
Inhibition of quisqualate-induced seizures by glutamic acid diethyl ester and anti-epileptic drugs.
Topics: Aminooxyacetic Acid; Animals; Anticonvulsants; Carbamazepine; Diazepam; Female; Glutamates; Mice; Ox | 1986 |
Influence of valproic acid on the gonadotropin-releasing hormone test in puberty.
Topics: Adolescent; Child; Female; Follicle Stimulating Hormone; Humans; Luteinizing Hormone; Male; Pituitar | 1986 |
[Synergic effect of GABA and glycine in the antagonism of convulsions caused by pentetrazole in rats. Study of glycine valproamide].
Topics: Animals; Drug Synergism; gamma-Aminobutyric Acid; Glycine; Male; Pentylenetetrazole; Rats; Rats, Inb | 1986 |
Benign juvenile myoclonic epilepsy.
Topics: Adolescent; Adult; Electroencephalography; Epilepsies, Myoclonic; Female; Humans; Male; Seizures; Va | 1987 |
Breakthrough seizure following substitution of Depakene capsules (Abbott) with a generic product.
Topics: Adult; Female; Humans; Seizures; Therapeutic Equivalency; Valproic Acid | 1987 |
The development of tolerance to the anticonvulsant effects of clonazepam, but not sodium valproate, in the amygdaloid kindled rat.
Topics: Amygdala; Animals; Anticonvulsants; Clonazepam; Drug Tolerance; Kindling, Neurologic; Male; Rats; Ra | 1987 |
Photosensitivity related to valproate withdrawal.
Topics: Adolescent; Adult; Female; Humans; Light; Male; Middle Aged; Seizures; Substance Withdrawal Syndrome | 1987 |
Valproic acid efficacy, toxicity, and pharmacokinetics in neonates with intractable seizures.
Topics: Absorption; Ammonia; Humans; Infant, Newborn; Osmolar Concentration; Seizures; Valproic Acid | 1988 |
Computerized EEG analysis of penicillin induced seizure threshold in developing rats.
Topics: Aging; Animals; Computers; Disease Models, Animal; Electroencephalography; Epilepsy; Penicillins; Ra | 1987 |
Rectal anticonvulsants in pediatric practice.
Topics: Administration, Rectal; Adolescent; Anticonvulsants; Benzodiazepines; Carbamazepine; Child, Preschoo | 1988 |
Marked increase in anticonvulsant activity but decrease in wet-dog shake behaviour during short-term treatment of amygdala-kindled rats with valproic acid.
Topics: Amygdala; Animals; Anticonvulsants; Behavior, Animal; Female; Kindling, Neurologic; Rats; Rats, Inbr | 1988 |
Anticonvulsant potency and neurotoxicity of valproate alone and in combination with carbamazepine or phenobarbital.
Topics: Animals; Brain; Carbamazepine; Drug Interactions; Drug Therapy, Combination; Electroshock; Female; M | 1988 |
Sodium valproate decreases synaptic potentiation and epileptiform activity in hippocampus.
Topics: Action Potentials; Animals; Anticonvulsants; Hippocampus; In Vitro Techniques; Rats; Seizures; Valpr | 1988 |
Effects of pregnancy on seizure threshold and the disposition and efficacy of antiepileptic drugs in the mouse.
Topics: Animals; Anticonvulsants; Carbamazepine; Electroshock; Female; Kinetics; Mice; Phenobarbital; Phenyt | 1985 |
Effect of stimulus intensity on the profile of anticonvulsant activity of phenytoin, ethosuximide and valproate.
Topics: Animals; Anticonvulsants; Bicuculline; Electroshock; Ethosuximide; Male; Mice; Pentylenetetrazole; P | 1985 |
Valproic acid therapy and neural tube defects.
Topics: Abortion, Induced; Adult; Amniocentesis; Female; Genetic Counseling; Humans; Neural Tube Defects; Pr | 1985 |
Valproylcarnitine: a novel drug metabolite identified by fast atom bombardment and thermospray liquid chromatography-mass spectrometry.
Topics: Adolescent; Carnitine; Child; Child, Preschool; Chromatography, High Pressure Liquid; Humans; Isomer | 1985 |
A timed intravenous pentylenetetrazol infusion seizure model for quantitating the anticonvulsant effect of valproic acid in the rat.
Topics: Animals; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Infusions, Parenteral; Mal | 1985 |
Effect of different doses of valproic acid on the serum levels of total and free diphenylhydantoin.
Topics: Adolescent; Adult; Aged; Female; Humans; Male; Phenytoin; Prospective Studies; Seizures; Valproic Ac | 1985 |
Anticonvulsant drugs and the genetically epilepsy-prone rat.
Topics: Acoustic Stimulation; Amitriptyline; Animals; Anticonvulsants; Carbamazepine; Desipramine; Disease M | 1985 |
The specific protective effect of diazepam and valproate against isoniazid-induced seizures is not correlated with increased GABA levels.
Topics: Amino Acids; Animals; Diazepam; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Isoniazid | 1985 |
Free level monitoring of carbamazepine and valproic acid: clinical significance.
Topics: Adolescent; Adult; Aged; Carbamazepine; Child; Dose-Response Relationship, Drug; Female; Humans; Imm | 1985 |
Seizure control following administration of anticonvulsant drugs in the quaking mouse.
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Ethosuximide; Mice; Mice, Inbred C57BL; Mice, Qua | 1985 |