valproic acid has been researched along with Sarcoma in 1 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Sarcoma: A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present studies were to determine whether the multi-kinase inhibitor pazopanib interacted with histone deacetylase inhibitors (HDACI: valproate, vorinostat) to kill sarcoma cells." | 7.80 | Pazopanib and HDAC inhibitors interact to kill sarcoma cells. ( Dent, P; Grant, S; Hamed, HA; Poklepovic, A; Tavallai, S, 2014) |
| "The present studies were to determine whether the multi-kinase inhibitor pazopanib interacted with histone deacetylase inhibitors (HDACI: valproate, vorinostat) to kill sarcoma cells." | 3.80 | Pazopanib and HDAC inhibitors interact to kill sarcoma cells. ( Dent, P; Grant, S; Hamed, HA; Poklepovic, A; Tavallai, S, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tavallai, S | 1 |
| Hamed, HA | 1 |
| Grant, S | 1 |
| Poklepovic, A | 1 |
| Dent, P | 1 |
1 other study available for valproic acid and Sarcoma
| Article | Year |
|---|---|
Pazopanib and HDAC inhibitors interact to kill sarcoma cells.
Topics: Animals; Antineoplastic Agents; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein | 2014 |
Pazopanib and HDAC inhibitors interact to kill sarcoma cells.
Topics: Animals; Antineoplastic Agents; Apoptosis Regulatory Proteins; Autophagy; Autophagy-Related Protein | 2014 |