valproic acid has been researched along with Sarcoma, Kaposi in 2 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Sarcoma, Kaposi: A multicentric, malignant neoplastic vascular proliferation characterized by the development of bluish-red cutaneous nodules, usually on the lower extremities, most often on the toes or feet, and slowly increasing in size and number and spreading to more proximal areas. The tumors have endothelium-lined channels and vascular spaces admixed with variably sized aggregates of spindle-shaped cells, and often remain confined to the skin and subcutaneous tissue, but widespread visceral involvement may occur. Kaposi's sarcoma occurs spontaneously in Jewish and Italian males in Europe and the United States. An aggressive variant in young children is endemic in some areas of Africa. A third form occurs in about 0.04% of kidney transplant patients. There is also a high incidence in AIDS patients. (From Dorland, 27th ed & Holland et al., Cancer Medicine, 3d ed, pp2105-7) HHV-8 is the suspected cause.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The AIDS Malignancy Consortium undertook a pilot trial of valproic acid among patients with AIDS-associated Kaposi sarcoma (KS)." | 7.75 | Molecular and clinical assessment in the treatment of AIDS Kaposi sarcoma with valproic Acid. ( Aboulafia, D; Ambinder, RF; Dezube, BJ; Dittmer, DP; Krown, SE; Lechowicz, M; Lee, JY; Ratner, L; Said, J; Wachsman, W, 2009) |
| "The AIDS Malignancy Consortium undertook a pilot trial of valproic acid among patients with AIDS-associated Kaposi sarcoma (KS)." | 3.75 | Molecular and clinical assessment in the treatment of AIDS Kaposi sarcoma with valproic Acid. ( Aboulafia, D; Ambinder, RF; Dezube, BJ; Dittmer, DP; Krown, SE; Lechowicz, M; Lee, JY; Ratner, L; Said, J; Wachsman, W, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Al-Kzayer, LF | 1 |
| Keizer, P | 1 |
| Abdulraheem, FT | 1 |
| Sano, K | 1 |
| Kamata, M | 1 |
| Sakashita, K | 1 |
| Habbaba, LA | 1 |
| Koike, K | 1 |
| Lechowicz, M | 1 |
| Dittmer, DP | 1 |
| Lee, JY | 1 |
| Krown, SE | 1 |
| Wachsman, W | 1 |
| Aboulafia, D | 1 |
| Dezube, BJ | 1 |
| Ratner, L | 1 |
| Said, J | 1 |
| Ambinder, RF | 1 |
1 review available for valproic acid and Sarcoma, Kaposi
| Article | Year |
|---|---|
Rapidly progressive Kaposi's Sarcoma in an Iraqi boy received Valproic acid: a case report and review of literature.
Topics: Anticonvulsants; Child; Disease Progression; Fatal Outcome; Humans; Immunosuppressive Agents; Iraq; | 2016 |
1 other study available for valproic acid and Sarcoma, Kaposi
| Article | Year |
|---|---|
Molecular and clinical assessment in the treatment of AIDS Kaposi sarcoma with valproic Acid.
Topics: Acquired Immunodeficiency Syndrome; Adult; Female; Herpesvirus 8, Human; Humans; Male; Middle Aged; | 2009 |