valproic acid has been researched along with Rhabdomyosarcoma in 6 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Rhabdomyosarcoma: A malignant solid tumor arising from mesenchymal tissues which normally differentiate to form striated muscle. It can occur in a wide variety of sites. It is divided into four distinct types: pleomorphic, predominantly in male adults; alveolar (RHABDOMYOSARCOMA, ALVEOLAR), mainly in adolescents and young adults; embryonal (RHABDOMYOSARCOMA, EMBRYONAL), predominantly in infants and children; and botryoidal, also in young children. It is one of the most frequently occurring soft tissue sarcomas and the most common in children under 15. (From Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p2186; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, pp1647-9)
| Excerpt | Relevance | Reference |
|---|---|---|
| " We subsequently tested the combination of valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, with caffeine on established human osteosarcoma cells in vitro." | 7.85 | Efficacy In Vitro of Caffeine and Valproic Acid on Patient-Derived Undifferentiated Pleomorphic Sarcoma and Rhabdomyosarcoma Cell Lines. ( Dry, SM; Eilber, FC; Hayashi, K; Hoffman, RM; Igarashi, K; Kawaguchi, K; Kimura, H; Kiyuna, T; Li, Y; Miwa, S; Murakami, T; Nelson, SD; Singh, AS; Tsuchiya, H; Yamamoto, N, 2017) |
| "Valproic acid (VPA) is a HDAC inhibitor that has antitumor activity at mM range." | 5.43 | N-(2-hydroxyphenyl)-2-propylpentanamide, a valproic acid aryl derivative designed in silico with improved anti-proliferative activity in HeLa, rhabdomyosarcoma and breast cancer cells. ( Bermúdez-Lugo, JA; Chávez-Blanco, A; Correa-Basurto, AM; Correa-Basurto, J; Dueñas-González, A; Fragoso-Vázquez, MJ; García-Sánchez, JR; Méndez-Luna, D; Mendieta-Wejebe, JE; Padilla-Martínez, II; Pérez-González, OA; Prestegui-Martel, B; Trujillo-Ferrara, J, 2016) |
| " We subsequently tested the combination of valproic acid (VPA), a histone deacetylase (HDAC) inhibitor, with caffeine on established human osteosarcoma cells in vitro." | 3.85 | Efficacy In Vitro of Caffeine and Valproic Acid on Patient-Derived Undifferentiated Pleomorphic Sarcoma and Rhabdomyosarcoma Cell Lines. ( Dry, SM; Eilber, FC; Hayashi, K; Hoffman, RM; Igarashi, K; Kawaguchi, K; Kimura, H; Kiyuna, T; Li, Y; Miwa, S; Murakami, T; Nelson, SD; Singh, AS; Tsuchiya, H; Yamamoto, N, 2017) |
| "Valproic acid (VPA) is a HDAC inhibitor that has antitumor activity at mM range." | 1.43 | N-(2-hydroxyphenyl)-2-propylpentanamide, a valproic acid aryl derivative designed in silico with improved anti-proliferative activity in HeLa, rhabdomyosarcoma and breast cancer cells. ( Bermúdez-Lugo, JA; Chávez-Blanco, A; Correa-Basurto, AM; Correa-Basurto, J; Dueñas-González, A; Fragoso-Vázquez, MJ; García-Sánchez, JR; Méndez-Luna, D; Mendieta-Wejebe, JE; Padilla-Martínez, II; Pérez-González, OA; Prestegui-Martel, B; Trujillo-Ferrara, J, 2016) |
| " To determine the role of gene overexpression on chromosome instability (CIN), we performed genome-wide screens in the budding yeast for yeast genes that cause CIN when overexpressed, a phenotype we refer to as dosage CIN (dCIN), and identified 245 dCIN genes." | 1.43 | Overexpression screens identify conserved dosage chromosome instability genes in yeast and human cancer. ( Andrews, B; Ang, JS; Boerkoel, CF; Duffy, S; Fam, HK; Hieter, P; Kim, JH; Larionov, V; Shah, SP; Singh, T; Styles, EB; Wang, YK, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 5 (83.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jarząb, A | 1 |
| Łuszczki, JJ | 1 |
| Guz, M | 1 |
| Gumbarewicz, E | 1 |
| Polberg, K | 1 |
| Stepulak, A | 1 |
| Igarashi, K | 1 |
| Kawaguchi, K | 1 |
| Kiyuna, T | 1 |
| Murakami, T | 1 |
| Miwa, S | 1 |
| Nelson, SD | 1 |
| Dry, SM | 1 |
| Li, Y | 1 |
| Singh, AS | 1 |
| Kimura, H | 1 |
| Hayashi, K | 1 |
| Yamamoto, N | 1 |
| Tsuchiya, H | 1 |
| Eilber, FC | 1 |
| Hoffman, RM | 1 |
| Prestegui-Martel, B | 1 |
| Bermúdez-Lugo, JA | 1 |
| Chávez-Blanco, A | 1 |
| Dueñas-González, A | 1 |
| García-Sánchez, JR | 1 |
| Pérez-González, OA | 1 |
| Padilla-Martínez, II | 1 |
| Fragoso-Vázquez, MJ | 1 |
| Mendieta-Wejebe, JE | 1 |
| Correa-Basurto, AM | 1 |
| Méndez-Luna, D | 1 |
| Trujillo-Ferrara, J | 1 |
| Correa-Basurto, J | 1 |
| Duffy, S | 1 |
| Fam, HK | 1 |
| Wang, YK | 1 |
| Styles, EB | 1 |
| Kim, JH | 1 |
| Ang, JS | 1 |
| Singh, T | 1 |
| Larionov, V | 1 |
| Shah, SP | 1 |
| Andrews, B | 1 |
| Boerkoel, CF | 1 |
| Hieter, P | 1 |
| Ecke, I | 1 |
| Petry, F | 1 |
| Rosenberger, A | 1 |
| Tauber, S | 1 |
| Mönkemeyer, S | 1 |
| Hess, I | 1 |
| Dullin, C | 1 |
| Kimmina, S | 1 |
| Pirngruber, J | 1 |
| Johnsen, SA | 1 |
| Uhmann, A | 1 |
| Nitzki, F | 1 |
| Wojnowski, L | 1 |
| Schulz-Schaeffer, W | 1 |
| Witt, O | 2 |
| Hahn, H | 1 |
| Blattmann, C | 1 |
| Oertel, S | 1 |
| Ehemann, V | 1 |
| Thiemann, M | 1 |
| Huber, PE | 1 |
| Bischof, M | 1 |
| Deubzer, HE | 1 |
| Kulozik, AE | 1 |
| Debus, J | 1 |
| Weber, KJ | 1 |
6 other studies available for valproic acid and Rhabdomyosarcoma
| Article | Year |
|---|---|
Additive Interaction of Cisplatin and Histone Deacetylase Inhibitors Combined Treatment in Rhabdomyosarcoma Cells - An Isobolographic Analysis.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; | 2017 |
Efficacy In Vitro of Caffeine and Valproic Acid on Patient-Derived Undifferentiated Pleomorphic Sarcoma and Rhabdomyosarcoma Cell Lines.
Topics: Apoptosis; Caffeine; Cell Line, Tumor; Cell Proliferation; Drug Synergism; Histone Deacetylase Inhib | 2017 |
N-(2-hydroxyphenyl)-2-propylpentanamide, a valproic acid aryl derivative designed in silico with improved anti-proliferative activity in HeLa, rhabdomyosarcoma and breast cancer cells.
Topics: Amides; Antineoplastic Agents; Breast Neoplasms; Cell Proliferation; Computer Simulation; Dose-Respo | 2016 |
Overexpression screens identify conserved dosage chromosome instability genes in yeast and human cancer.
Topics: Cell Line, Tumor; Chromosomal Instability; Gene Expression Regulation, Neoplastic; Histone Deacetyla | 2016 |
Antitumor effects of a combined 5-aza-2'deoxycytidine and valproic acid treatment on rhabdomyosarcoma and medulloblastoma in Ptch mutant mice.
Topics: Acetylation; Animals; Antineoplastic Combined Chemotherapy Protocols; Azacitidine; Decitabine; DNA ( | 2009 |
Enhancement of radiation response in osteosarcoma and rhabdomyosarcoma cell lines by histone deacetylase inhibition.
Topics: Antigens, Nuclear; Apoptosis; Carrier Proteins; Cell Cycle; Cell Line, Tumor; Cell Survival; DNA Rep | 2010 |