valproic acid has been researched along with Rhabdomyolysis in 8 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Rhabdomyolysis: Necrosis or disintegration of skeletal muscle often followed by myoglobinuria.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The current study investigated the effects of treatment with 300 mg/kg valproic acid on rhabdomyolysis and acute kidney injury induced by intramuscular injection of hypertonic glycerol in rats." | 8.02 | Valproate attenuates hypertonic glycerol-induced rhabdomyolysis and acute kidney injury. ( Abd-Eldayem, AM; Abdelzaher, LA; Badary, DM; Hareedy, MS; Mohammed Alnasser, S, 2021) |
| "A 47-year-old man suffering from a bipolar disorder and intermittent myoglobinuria presented with acute rhabdomyolysis with renal failure after starting therapy with valproic acid." | 7.71 | Valproic acid triggers acute rhabdomyolysis in a patient with carnitine palmitoyltransferase type II deficiency. ( Glocker, FX; Jaksch, M; Ketelsen, UP; Kottlors, M; Lücking, CH; Weiner, S, 2001) |
| "Valproic acid (VPA) has been widely used more frequently as its approved indications have been expanded." | 5.62 | Rhabdomyolysis and Hepatotoxicity From Valproic Acid: Case Reports. ( Deb, S; Walker, CP, 2021) |
| "The current study investigated the effects of treatment with 300 mg/kg valproic acid on rhabdomyolysis and acute kidney injury induced by intramuscular injection of hypertonic glycerol in rats." | 4.02 | Valproate attenuates hypertonic glycerol-induced rhabdomyolysis and acute kidney injury. ( Abd-Eldayem, AM; Abdelzaher, LA; Badary, DM; Hareedy, MS; Mohammed Alnasser, S, 2021) |
| "We describe an 11-year-old girl with a seizure disorder who developed fever, rash, rhabdomyolysis, and multiorgan failure 2 weeks after commencing a transition from sodium valproate to lamotrigine therapy." | 3.75 | Life-threatening organ failure after lamotrigine therapy. ( Dargan, PI; Ferguson, LP; Hood, JL; Tibby, SM, 2009) |
| "A 47-year-old man suffering from a bipolar disorder and intermittent myoglobinuria presented with acute rhabdomyolysis with renal failure after starting therapy with valproic acid." | 3.71 | Valproic acid triggers acute rhabdomyolysis in a patient with carnitine palmitoyltransferase type II deficiency. ( Glocker, FX; Jaksch, M; Ketelsen, UP; Kottlors, M; Lücking, CH; Weiner, S, 2001) |
| "Valproic acid (VPA) has been widely used more frequently as its approved indications have been expanded." | 1.62 | Rhabdomyolysis and Hepatotoxicity From Valproic Acid: Case Reports. ( Deb, S; Walker, CP, 2021) |
| "Extrapulmonary manifestations of an influenza A (H1N1) virus infection are rare but have to be considered after exclusion of differential diagnosis in younger patients in particular." | 1.39 | [Difficult course of rhabdomyolysis in influenza A/H1N1]. ( Fröhlich, G; Grawe, A; Märker-Hermann, E; Roth, R; Schmidt, N, 2013) |
| "Valproic acid is an effective antiseizure medication that is also used for other indications such as migraine prophylaxis." | 1.30 | Multiorgan system failure caused by valproic acid toxicity. ( Pinkston, R; Walker, LA, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (12.50) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 2 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Walker, CP | 1 |
| Deb, S | 1 |
| Hareedy, MS | 1 |
| Abdelzaher, LA | 1 |
| Badary, DM | 1 |
| Mohammed Alnasser, S | 1 |
| Abd-Eldayem, AM | 1 |
| Fröhlich, G | 1 |
| Grawe, A | 1 |
| Schmidt, N | 1 |
| Roth, R | 1 |
| Märker-Hermann, E | 1 |
| Ferguson, LP | 1 |
| Dargan, PI | 1 |
| Hood, JL | 1 |
| Tibby, SM | 1 |
| Kotbi, N | 1 |
| Mahgoub, N | 1 |
| Mokonogho, J | 1 |
| Young, R | 1 |
| Meyer, S | 1 |
| Martin, T | 1 |
| Löffler, G | 1 |
| Gortner, L | 1 |
| Pinkston, R | 1 |
| Walker, LA | 1 |
| Kottlors, M | 1 |
| Jaksch, M | 1 |
| Ketelsen, UP | 1 |
| Weiner, S | 1 |
| Glocker, FX | 1 |
| Lücking, CH | 1 |
8 other studies available for valproic acid and Rhabdomyolysis
| Article | Year |
|---|---|
Rhabdomyolysis and Hepatotoxicity From Valproic Acid: Case Reports.
Topics: Adult; Anticonvulsants; Blood Coagulation Disorders; Chemical and Drug Induced Liver Injury; Female; | 2021 |
Valproate attenuates hypertonic glycerol-induced rhabdomyolysis and acute kidney injury.
Topics: Acute Kidney Injury; Animals; Glycerol; Humans; Kidney; Male; Rats; Rhabdomyolysis; Valproic Acid | 2021 |
[Difficult course of rhabdomyolysis in influenza A/H1N1].
Topics: Acute Kidney Injury; Adult; Anticonvulsants; Combined Modality Therapy; Diagnosis, Differential; Hum | 2013 |
Life-threatening organ failure after lamotrigine therapy.
Topics: Anticonvulsants; Child; Contraindications; Drug Therapy, Combination; Exanthema; Female; Fever; Huma | 2009 |
Rhabdomyolysis associated with mania in late life.
Topics: Aged; Antimanic Agents; Bipolar Disorder; Humans; Male; Rhabdomyolysis; Treatment Outcome; Valproic | 2009 |
Severe rhabdomyolysis caused by valproic Acid in a neonate with seizures and chromosomal abnormalities.
Topics: Anticonvulsants; Chromosomes, Human, Pair 11; Dose-Response Relationship, Drug; Drug Therapy, Combin | 2011 |
Multiorgan system failure caused by valproic acid toxicity.
Topics: Acute Kidney Injury; Anticonvulsants; Emergencies; Humans; Liver Failure; Male; Middle Aged; Migrain | 1997 |
Valproic acid triggers acute rhabdomyolysis in a patient with carnitine palmitoyltransferase type II deficiency.
Topics: Acetylcarnitine; Acute Disease; Antimanic Agents; Bipolar Disorder; Carnitine O-Palmitoyltransferase | 2001 |