valproic acid has been researched along with Retinal Degeneration in 7 studies
Valproic Acid: A fatty acid with anticonvulsant and anti-manic properties that is used in the treatment of EPILEPSY and BIPOLAR DISORDER. The mechanisms of its therapeutic actions are not well understood. It may act by increasing GAMMA-AMINOBUTYRIC ACID levels in the brain or by altering the properties of VOLTAGE-GATED SODIUM CHANNELS.
valproic acid : A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Retinal Degeneration: A retrogressive pathological change in the retina, focal or generalized, caused by genetic defects, inflammation, trauma, vascular disease, or aging. Degeneration affecting predominantly the macula lutea of the retina is MACULAR DEGENERATION. (Newell, Ophthalmology: Principles and Concepts, 7th ed, p304)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Daily dosing of wild-type mice from postnatal day P17 to P28 resulted in smaller increases in Bdnf and Gdnf expression, normal Cntf expression, and reduced Fgf2 expression (25%)." | 5.40 | Different effects of valproic acid on photoreceptor loss in Rd1 and Rd10 retinal degeneration mice. ( Byrd, D; DeLooff, C; Deshpande, M; Guzman, AE; Laux, K; Metcalf, B; Mitton, KP; Mkoyan, K; Sotzen, J; Tran, T; Wallace, A; Zlojutro, P, 2014) |
| " Daily dosing of wild-type mice from postnatal day P17 to P28 resulted in smaller increases in Bdnf and Gdnf expression, normal Cntf expression, and reduced Fgf2 expression (25%)." | 1.40 | Different effects of valproic acid on photoreceptor loss in Rd1 and Rd10 retinal degeneration mice. ( Byrd, D; DeLooff, C; Deshpande, M; Guzman, AE; Laux, K; Metcalf, B; Mitton, KP; Mkoyan, K; Sotzen, J; Tran, T; Wallace, A; Zlojutro, P, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 5 (71.43) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Shen, H | 1 |
| Ding, C | 1 |
| Yuan, S | 1 |
| Pan, T | 1 |
| Li, D | 1 |
| Li, H | 1 |
| Huang, B | 1 |
| Liu, Q | 1 |
| Koriyama, Y | 1 |
| Sugitani, K | 1 |
| Ogai, K | 1 |
| Kato, S | 1 |
| Alsarraf, O | 1 |
| Fan, J | 1 |
| Dahrouj, M | 1 |
| Chou, CJ | 1 |
| Menick, DR | 1 |
| Crosson, CE | 1 |
| Mitton, KP | 1 |
| Guzman, AE | 1 |
| Deshpande, M | 1 |
| Byrd, D | 1 |
| DeLooff, C | 1 |
| Mkoyan, K | 1 |
| Zlojutro, P | 1 |
| Wallace, A | 1 |
| Metcalf, B | 1 |
| Laux, K | 1 |
| Sotzen, J | 1 |
| Tran, T | 1 |
| Kimura, A | 1 |
| Guo, X | 1 |
| Noro, T | 1 |
| Harada, C | 1 |
| Tanaka, K | 1 |
| Namekata, K | 1 |
| Harada, T | 1 |
| Daly, C | 1 |
| Yin, J | 1 |
| Kennedy, BN | 1 |
| Tilz, C | 1 |
| Wang-Tilz, Y | 1 |
| Jünemann, A | 1 |
| Stefan, H | 1 |
| Michelson, G | 1 |
7 other studies available for valproic acid and Retinal Degeneration
| Article | Year |
|---|---|
Vitamin C- and Valproic Acid-Induced Fetal RPE Stem-like Cells Recover Retinal Degeneration via Regulating SOX2.
Topics: Animals; Ascorbic Acid; Biomarkers; Cell Differentiation; Cell Proliferation; Cells, Cultured; Disea | 2020 |
Heat shock protein 70 induction by valproic acid delays photoreceptor cell death by N-methyl-N-nitrosourea in mice.
Topics: Alkylating Agents; Animals; Apoptosis; Blotting, Western; Chromatin Immunoprecipitation; Disease Mod | 2014 |
Acetylation: a lysine modification with neuroprotective effects in ischemic retinal degeneration.
Topics: Acetylation; Animals; Blotting, Western; Caspase 3; Cell Survival; Electroretinography; Female; Hist | 2014 |
Different effects of valproic acid on photoreceptor loss in Rd1 and Rd10 retinal degeneration mice.
Topics: Animals; Basic-Leucine Zipper Transcription Factors; Brain-Derived Neurotrophic Factor; Cyclic Nucle | 2014 |
Valproic acid prevents retinal degeneration in a murine model of normal tension glaucoma.
Topics: Amino Acid Transport System X-AG; Animals; Cell Survival; Glaucoma; Mice, Inbred C57BL; Mice, Knocko | 2015 |
Histone Deacetylase: Therapeutic Targets in Retinal Degeneration.
Topics: Animals; Apoptosis; Disease Models, Animal; Histone Deacetylase Inhibitors; Histone Deacetylases; Hu | 2016 |
Visual field defect during therapy with valproic-acid.
Topics: Adult; Epilepsy; Female; GABA Agents; gamma-Aminobutyric Acid; Humans; Retina; Retinal Degeneration; | 2007 |